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See detailElp3 Lysine Acetyl-Transferase Controls Neuronal Survival in the Developing Inner Ear and is Crucial to Balance and Hearing
Delacroix, Laurence ULg; Mateo Sanchez, Susana ULg; Freeman, Stephen ULg et al

Conference (2016, February 20)

Elp3 lysine acetyl-transferase, the catalytic subunit of the Elongator complex, has been assigned multiple roles in gene transcription, DNA methylation and protein translation efficiency. Given the ... [more ▼]

Elp3 lysine acetyl-transferase, the catalytic subunit of the Elongator complex, has been assigned multiple roles in gene transcription, DNA methylation and protein translation efficiency. Given the importance of acetylation homeostasis in controlling developmental processes together with recent reports implicating Elp3 in cortical neurogenesis, we investigated its role during inner ear formation. In the inner ear, we detected Elp3 transcript in the sensory epithelia of the entire otic vesicle at embryonic day E11.5. At later stages, Elp3 mRNA is strongly expressed in the vestibular and spiral ganglion neurons. To investigate the role of Elp3 in vivo, we used a conditional knock-out mice (Foxg1Cre) in which the expression of the acetyl-transferase is lost in early otocyst. These mice show obvious vestibular defects as indicated by a stereotyped circling ambulation, head bobbing, retropulsion and the absence of a reaching response in the tail-hanging test. Furthermore, we identified a severe hearing loss in Elp3cKO mice through Auditory Brainstem Responses. We show that Elp3 enzyme is crucial for neuronal survival in the spiral ganglion and in the vestibule and that it ensures a correct innervation pattern in the developing inner ear. In the absence of Elp3, a drastic increase in the number of apoptotic neurons was detected by active Caspase-3 and pH2AX immunostainings, particularly during the early stages of development (between E12.5 and E14.5). Postnatally, the neurons remaining in Elp3cKO cochleae seem to establish synaptic contacts with the sensory cells but show obvious signs of cell damage as evidenced by Transmission Electron Microscopy. Taken together, these data support a role for Elp3 in hearing and balance and point out an important role for acetylation homeostasis during inner ear formation. We are currently investigating the molecular mechanisms underlying Elp3 effect on neuronal survival and pathfinding. [less ▲]

Detailed reference viewed: 29 (5 ULg)
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See detailLes dysphasies : nouvelles conceptions théoriques et implications cliniques
Maillart, Christelle ULg

Conference (2016, February 20)

Detailed reference viewed: 43 (3 ULg)
See detailLa régionalisation de l'IPP
Bourgeois, Marc ULg

Conference given outside the academic context (2016)

Detailed reference viewed: 9 (0 ULg)
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See detailBlack British women filmmakers: towards a genderracial Cinema ?
Herbert, Emilie ULg

Conference (2016, February 19)

Detailed reference viewed: 21 (1 ULg)
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See detailDe uitspraak van Franstalige CLIL-leerders van het Nederlands
Vanackere, Laurine; Van Pée, Marie; Hiligsmann, Philippe et al

Conference (2016, February 19)

Detailed reference viewed: 23 (0 ULg)
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See detailComputerized adaptive and multi-stage testing with R
Yan, Duanli; Magis, David ULg

Conference (2016, February 19)

Computerized Adaptive Testing (CAT) has greatly improved the accuracy and efficiency of psychological testing for decades. Multistage Testing (MST) has received much of attention recently. MST is similar ... [more ▼]

Computerized Adaptive Testing (CAT) has greatly improved the accuracy and efficiency of psychological testing for decades. Multistage Testing (MST) has received much of attention recently. MST is similar to CAT such that it allows the adaptation of the difficulty of the test to the level of ability of a test taker. Specifically, in MST, items are interactively selected for each test taker, but rather than selecting individual items, groups of items are selected and the test is built in stages. Over the last decade, researchers have investigated ways for an MST to incorporate most of the advantages from CAT and linear testing, while minimize their disadvantages. These features include testing efficiency and accuracy, greater control of test content, more robust item review, as well as simplified test assembly and administration. Therefore, MST can be an effective compromise between CAT and linear testing, embedding features and benefits from both designs. Thus, MST becomes of more and more interest to researchers and practitioners as technology advances. This presentation will first provide a general overview of a multistage test (MST) design and its important concepts and processes. It will then present the latest development on CAT and MST using R, the mstR package. The presentation will also illustrate how to simulate MST administrations using mstR package, and discuss some practical issues and considerations for MST from design to applications. [less ▲]

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See detailIntegrin αvβ3 and RGD-based radiopharmaceuticals
WITHOFS, Nadia ULg; HUSTINX, Roland ULg

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2016), 40 (2016)

Positron emission tomography combined with computed tomography (PET/CT) using RGD-based radiopharmaceuticals allows quantification of tumour expression of integrin αvβ3 in vivo. Integrins and, in ... [more ▼]

Positron emission tomography combined with computed tomography (PET/CT) using RGD-based radiopharmaceuticals allows quantification of tumour expression of integrin αvβ3 in vivo. Integrins and, in particular, integrin αvβ3 are involved in numerous physiologic and pathologic processes, including angiogenesis. RGD-based radiopharmaceuticals targeting integrin αvβ3, expressed by activated endothelial cells, have been developed in order to quantify angiogenesis. However, integrin αvβ3 is also frequently expressed by tumour cells and/or tumour microenvironment cells, e.g., bone marrow derived cells and osteoclasts in bone. Upregulation of integrin αvβ3 by tumour cells promotes cell survival, proliferation, invasion, metastasis and resistance to treatment. Therefore, the PET signal related to RGD-based radiopharmaceuticals may not reflect angiogenesis only. Moreover, tumours may develop mechanisms other than angiogenesis to ensure blood supply such as vascular mimicry, vessel co-option and intussusceptive angiogenesis that might not be assessed with RGD PET/CT. In the setting of treatment assessment, a drop of the RGD PET signal certainly means tumour response (endothelial and/or tumour cell apoptosis and/or vessel normalisation). On the other hand, a stable or increased RGD PET signal may be related to absence of response or upregulation of integrin αvβ3 in adaptative response to therapy, promoting resistance. This review illustrates the complexity of the role of integrin αvβ3 in oncology and its role in non-oncologic diseases such as osteoarthtitis and cardiovascular diseases. [less ▲]

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See detail'Zetten' of 'leggen': hoe Franstalige leerders van het Nederlands spreken en gebaren over plaatsingsverschijnselen
Heyvaert, Pauline ULg

Conference (2016, February 19)

This research presents the results of a quantitative and qualitative analysis of the use of the Dutch placement verbs zetten (‘put’) and leggen (‘lay’) by French-speaking learners of Dutch. The experiment ... [more ▼]

This research presents the results of a quantitative and qualitative analysis of the use of the Dutch placement verbs zetten (‘put’) and leggen (‘lay’) by French-speaking learners of Dutch. The experiment consisted of two parts: a receptive as well as a productive part. The analysis focused on two aspects: speech, but also the gestures made by the participants were both quantitatively and qualitatively analyzed. The results confirm that the use of Dutch placement verbs is problematic for French-speaking learners of Dutch, but they also reveal some important tendencies. First, my analysis demonstrates that French-speaking learners tend to underuse these verbs, which can be explained by the fact that placement events in French are often described by means of a neutral verb such as mettre (‘put’) as opposed to the more specific verbs in Dutch. Secondly, the learners occasionally also tend to overuse the placement verbs in contexts where such verbs are not allowed, an observation which is seemingly paradoxical to the first one. Thirdly, some learners also tend to confuse zetten with leggen and vice versa. These findings are interesting given that the Dutch placement verbs, with a few exceptions, remain a relatively unexplored area within the field of linguistics. [less ▲]

Detailed reference viewed: 28 (8 ULg)
See detailBreaking or Remaking Colonial Stereotypes? Female Figures in Contemporary Germanophone Literature: Urs Widmer, Alex Capus and Lukas Bärfuss
Beck, Laura ULg

Scientific conference (2016, February 19)

In the last 20 years, germanophone literature has displayed an increasing postcolonial sensibility regarding the representation of European colonial past and the literary creation of the colonized Other ... [more ▼]

In the last 20 years, germanophone literature has displayed an increasing postcolonial sensibility regarding the representation of European colonial past and the literary creation of the colonized Other as well as the general representation of cultural foreigness. Contemporary germanophone literature is, it seems, more and more interested in breaking and productively dealing with colonial stereotypes such as the figure of the natural, barbaric, irrational, passive colonized Other as opposed to the one of the civilized and civilizing, rational, active and colonizing European. Binary categories between the Other and the Self are increasingly challenged and replaced by more balanced representations of cultural and intracultural diversities and hybridities. Irony, figures of inversion and polyphony take an important part in this postcolonial remapping of European colonial entanglement. At the same time postcolonial germanophone literature displays a growing preoccupation with the question of how to represent voices of the Other and how to insert other perspectives into the texts; with all the problems of legitimization that come along with it. Nevertheless it seems as if all this postcolonial sensibility fails utterly when it comes to the representation of European and non-European women in colonial and postcolonial contexts who are represented in rather conventional ways. Clichés such as the voluptuous, oversexualized and dangerous African woman as opposed to the pure and motherly white woman who guarantees European progeny and prevents male going native are still recurrent in otherwise subversive texts. But, at first sight, both European and non-European female figures remain conspicuously silent. The talk focuses on three contemporary germanophone novels, Urs Widmers "Im Kongo" (1996), Alex Capus’ "Eine Frage der Zeit" (2007) and Lukas Bärfuss’ "Hundert Tage" (2008), and examine the breaking and remaking of colonial stereotypes regarding the representation of their female figures. [less ▲]

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See detailIdentifying Late Egyptian Virtual Relative Clauses
Sojic, Nathalie ULg

Conference (2016, February 19)

Ancient Egyptian so-called "virtual" relative clauses (VRC) are adverbial clauses that function like relative clauses. Descriptions provided by Late Egyptian grammars inform students of their existence ... [more ▼]

Ancient Egyptian so-called "virtual" relative clauses (VRC) are adverbial clauses that function like relative clauses. Descriptions provided by Late Egyptian grammars inform students of their existence and of the possibility to translate them accordingly. But they are not of a great help if one wants to grasp and describe the Late Egyptian relativization system in a linguistic perspective. The talk, given on the occasion of the international Crossroads V conference, aimed at providing interpretive guidelines based on syntax, pragmatics and Discourse Analysis. In my communication, I showed that Discourse Analysis proved to be very fruitful in clarifying some contexts of use of LEg VRCs as well as some interpretive processes. [less ▲]

Detailed reference viewed: 20 (1 ULg)
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See detailRetirement and cognitive functioning: A tricky association
Grotz, Catherine ULg; Adam, Stéphane ULg

in Pachana, N.A. (Ed.) Encyclopedia of Geropsychology (2016)

Detailed reference viewed: 20 (3 ULg)
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See detailThe Egyptianness of the Coptic basic vocabulary: A typological view
Grossman, Eitan; Polis, Stéphane ULg

Conference (2016, February 18)

The notion of ‘basic vocabulary’ is associated with the linguist and anthropologist Morris Swadesh, who proposed a list of 200 (and later 100) items. These lists, while widely used in historical and ... [more ▼]

The notion of ‘basic vocabulary’ is associated with the linguist and anthropologist Morris Swadesh, who proposed a list of 200 (and later 100) items. These lists, while widely used in historical and comparative linguistics, are based on Swadesh’s intuitions rather than on empirical research. More recently, however, the Leipzig Loanword Typology Project conducted a cross-linguistic survey of loanwords (Haspelmath & Tadmor 2009). One of the results is a 100-item list of basic vocabulary entries — the ‘Leipzig-Jakarta list of basic vocabulary.’ This list is the product of four factors, computed for a database of 1440 meanings in 41 languages: borrowability, representation in the database, analyzability / simplicity, and age. As Tadmor (2009) points out, this is the first list of basic vocabulary items based on extensive cross-linguistic comparison, and it constitutes a ‘full-fledged basic vocabulary’ that ‘comprises the notions normally associated with this concept: stability (our age score), universality (our representation score) and simplicity (our analyzability score), as well as resistance to borrowing (our unborrowed score)’ (2009: 68). In this talk, we examine this list of 100 meanings in order to evaluate the influence of Greek on the Coptic basic vocabulary, or — to put it the other way around — the ‘Egyptian¬ness’ of the Coptic lexicon, which seems to reflect an intense language contact situation. As a first step, Coptic data were collected from Crum (1939), the most extensive Coptic dictionary, for four dialects: Sahidic, Bohairic, Fayyumic, and Akhmimic. All Coptic lexemes associated with a meaning on the list were collected, even if poorly attested. Additionally, a questionnaire was been submitted to Copticists in order to detect Greek loanwords that would also be used for expressing these 100 meanings. Furthermore, we used etymological tools (Černý 1976; Westendorf 1977; Vycichl 1983) in order to attribute an age score (from 0 = Greek loanword to 4 = Old Egyptian) to the lexemes at two levels: the formal level (when is the word first attested in Ancient Egyptian) and the semantic level (when is the Coptic meaning first associated with this word). The vast majority of meanings (ca. 85%) have at least one pre-Coptic Egyptian cognate, most of which are already attested in Old Kingdom texts. As a result of this study, we are able (1) to evaluate the influence of Greek on the basic vocabulary of the main Coptic dialects, (2) to describe the basic vocabulary of Coptic dialects independently and to observe how they differ from one another, (3) to produce a first estimate of the rate of change in basic vocabularies over the course of Egyptian as a whole. [less ▲]

Detailed reference viewed: 24 (0 ULg)
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See detailRéception du jeu vidéo
Delbouille, Julie ULg

Scientific conference (2016, February 18)

Jeune, masculin, asocial : de nombreuses étiquettes sont associées par la presse et par le grand public aux amateurs de jeu vidéo. En se penchant non seulement sur les « publics du jeu vidéo », mais ... [more ▼]

Jeune, masculin, asocial : de nombreuses étiquettes sont associées par la presse et par le grand public aux amateurs de jeu vidéo. En se penchant non seulement sur les « publics du jeu vidéo », mais également sur les discours véhiculés sur le médium, cette séance de cours vise à déconstruire les clichés habituellement associés au jeu vidéo et à restituer la place réelle que cette pratique culturelle occupe dans le monde francophone. [less ▲]

Detailed reference viewed: 57 (6 ULg)
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See detailSecond argument realization in Earlier Egyptian
Motte, Aurore ULg; Winand, Jean ULg

Conference (2016, February 18)

Detailed reference viewed: 18 (4 ULg)