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See detailClinical components linked to sarcopenia: the sarcophage study
Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg; Petermans, Jean ULg et al

in Journal of Frailty & Aging (2015), 4(S1), 89

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See detailLattice dynamics in antimony and tellurium based phase-change materials
Simon, Ronnie Ernst ULg

Doctoral thesis (2015)

Detailed reference viewed: 31 (3 ULg)
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See detailOn the disruptive potential of 3D printing
Delvenne, Pierre ULg; Vigneron, Lara ULg

in Stokes, Elen (Ed.) Embedding and Governing New Technologies: A Regulatory, Ethical & Societal Perspective (2015)

Against the background of narratives fuelling big promises on the disruptive potential of 3D printing, this chapter seeks to describe a variety of contexts in which 3D printing technologies are expected ... [more ▼]

Against the background of narratives fuelling big promises on the disruptive potential of 3D printing, this chapter seeks to describe a variety of contexts in which 3D printing technologies are expected to emerge over the next 15 years and exert their so-called disruptive potential. In the section 2, we first provide a brief introduction to 3D printing and we explain how it actually works. Next, in section 3, we describe the paradigmatic change allowed by 3D printing in the industrial sector with a shift toward mass-customization. In particular, we focus on the biomedical sector (section 3.1.), which is an interesting case in point because of the important number of innovations and the growth of 3D printed biomedical parts, a trend which is expected to continue in the future. To account for the dramatic, transversal, and transformative potential that 3D printing has in that whole sector, we first concentrate on 3D printing of biomedical instruments and implants for patients (section 3.1.1.) and, second, on additive bio- manufacturing of human tissues and organs (section 3.1.2.). Then, in the subsequent section 4 we address the expectations raised by 3D printing to empowering users in non-industrial domains (e.g. in fabrication laboratories or with desktop 3D printers at home). In section 5, we turn to discussing the impact of 3D printing on the governance actors and we raise important issues for further research in the political economy of 3D printing technologies. The chapter posits that 3D printing, and its governance, are closely associated with more participatory means of manufacturing (and of decision- making, through various governance structures) – but that, as things currently stand, such openness and participation does not play out in practice. There is a distinction between the rhetoric and reality of 3D printing, as one might expect in the case of newly emerging technologies. [less ▲]

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See detailArtikelen van de 8e Anela Conferentie Toegepaste Taalwetenschap 2015
Bacchini, Sylvia; Van den Bogaerde, Beppie; Boogaard, Marianne et al

Book published by Eburon (2015)

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See detailMagnetic susceptibility application – a window onto ancient environments and climatic variations: Foreword
Da Silva, Anne-Christine ULg; Whalen; Hladil et al

in Special Publication - Geological Society of London (2015), 414

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See detailLower Carboniferous ramp sedimentation of the Central Alborz Basin, North Iran: integrated sedimentological and rock–magnetic studies.
Sardar Abadi, Mehrdad ULg; Da Silva, Anne-Christine ULg; Mosaddegh, hossein et al

in Special Publication - Geological Society of London (2015), 414

The Lower Carboniferous Mobarak Formation in the Alborz Basin (northern Iran) was deposited along the northeastern margin of Gondwana in a carbonate ramp setting. This paper focuses on the Tournaisian ... [more ▼]

The Lower Carboniferous Mobarak Formation in the Alborz Basin (northern Iran) was deposited along the northeastern margin of Gondwana in a carbonate ramp setting. This paper focuses on the Tournaisian stratigraphic interval of this formation that crops out at the Jaban section in the southwestern Central Alborz Basin. The following facies associations, representing different ramp palaeoenvironments, have been identified: (1) mudstone–wackestone outer-ramp facies; (2) crinoidal to skeletal grainstone–packstone mid-ramp facies; (3) peloidal to crinoidal grainstone–packstone inner-ramp facies; and (4) coastal facies, which include a variety of microbial laminated to oncoidal grainstones and mudstones with evaporitic pseudomorphs. This ramp profile was affected by frequent storms that were responsible for the formation of several skeletal to non-skeletal shoals in the distal mid-ramp to the most proximal inner-ramp areas. The development of the skeletal to non-skeletal shoals along the sea side of the ramp formed a semi-enclosed lagoon sensitive to the influence of both high tides and storm surges.The magnetic susceptibility (xin) of all the samples was measured and compared with that of the facies from which the sample was taken. There is a clear link between xin and the facies; the average xin values were higher for the distal facies than for the proximal facies. The xin profile of this Lower Carboniferous carbonate sequence reflects stratigraphic variations in response to relative changes in sea level and the input of detrital materials. In the context of the sequence stratigraphic framework, the average xin values for lowstand and transgressive systems tract deposits are higher than for the highstand systems tract deposits. The clear link between xin and facies indicates at least a partly preserved primary xin signal related to the detrital inputs. However, to obtain a better understanding of the nature and origin of the minerals carrying the xin, we performed hysteresis measurements on selected samples. It appears that the xin signal is mainly carried by lowcoercivity ferromagnetic minerals such as magnetite, with a mixture of relatively coarse grains (detrital fraction) and ultra-fine grains (probably formed during diagenesis). [less ▲]

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See detailBuilding the future of European sustainability governance: a critical self-reflexive approach to a participatory Technology Assessment exercise
Claisse, Frédéric ULg; Delvenne, Pierre ULg; Macq, Hadrien et al

Conference (2015)

Europe Wide Views (EWV) on Sustainable Consumption is a cross-European citizen consultation providing unique insights into the views of ordinary citizens across Europe on sustainable consumption and ... [more ▼]

Europe Wide Views (EWV) on Sustainable Consumption is a cross-European citizen consultation providing unique insights into the views of ordinary citizens across Europe on sustainable consumption and policies connected to this complex issue. The consultation took place simultaneously in 11 EU member states on October 25th 2014 and involved 1035 European citizens. Throughout the day, the participating citizens deliberated with fellow citizens and voted on issues relating to future policy-making on sustainable consumption. Overall, EWV was framed as a participatory Technology Assessment (pTA) exercise. Following the hypothesis that TA practitioners do not enough question the design of their projects’ and their own normative assumptions, we suggest to put the consultation we organised in Wallonia (Belgium) to the test. The aggregated results of the consultations point to the fact that “citizens are [now, after the EWV] strongly in favour of policy-makers taking ambitious steps in order to foster a more sustainable consumption in society, and want to personally take action in this process”. Relying on our previous work on dystopia as empowerment, we suggest a self-reflexive experiment to inquire into how much the design of the consultation (including the materials that were circulated) and the messages that we conveyed pictured a threatening present that would lead to an apocalyptic future ‘if nothing was done’, thereby potentially biasing the results that will are to be translated into political recommendations. Our analysis will benefit from cross-breeding future studies and science and technology studies to think afresh invisible normativities induced by pTA of sustainable governance. [less ▲]

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See detailWhat's next for Technology Assessment? Experiences and Insights from Wallonia, Belgium
Delvenne, Pierre ULg

Conference (2015)

A video of the presentation can be watched here: https://www.youtube.com/watch?v=Wlzpru9y5v4&index=18&list=PLgQy-FbfhVz4apGHLDWWEesazyeCg3hUf

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See detailActores valorizando la ciencia en regimenes científicos estrategicos
Charlier, Nathan ULg; Delvenne, Pierre ULg

Conference (2015)

With the underlying hypothesis of a shift toward strategic or neoliberal science regimes, much work has been done to analyze the multiple transformations of science institutions and policies over the last ... [more ▼]

With the underlying hypothesis of a shift toward strategic or neoliberal science regimes, much work has been done to analyze the multiple transformations of science institutions and policies over the last decades (e.g. Mirowski and Sent 2008; Slaughter & Rhoades, 2004; Bruno, 2008). The trends towards privatization and commodification of science are undisputable but we argue that little attention has been paid so far to the various political conceptions of research and innovation (R&I) coexisting within strategic science regimes. Cognitive approaches to public policy already stressed the circular relationship between meaning and power (e.g. Muller and Surel, 1998; Roe, 1994), but strategic science has remained out of the scope of such analyses. Regarding R&I policies, this leads to different ways to conceive of the “value” of science, some related to preexisting institutions and narratives, and some branching out toward new cognitive resources to achieve politico-economic aims. In this article, we hypothesize the coexistence of at least four justificatory narratives which help structuring the representations and actions of scientists and policymakers when they address science as a political object: ‘science for the sake of science’, ‘science, the endless frontier (continued)’, ‘knowledge-based economy’ and ‘grand societal challenges’. Each one attributes a different value to science, proposes a specific organization for the R&I system, and addresses the relation with economy and society differently. In order to understand how these justificatory narratives are locally enacted, and thereby grounded in R&I policymaking, we analyze the political discourses on science of actors from biotechnology labs, university management boards, and science policy advisory boards in Wallonia, French-speaking Belgium. We find traces of every of the four ideal-typical narratives that we identified, either in almost “pure” versions or in hybridized forms. We conclude that these developments are part of the same multidirectional movement of re-contextualization of science in society and we attend to some of the implications induced. [less ▲]

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See detailPhysiological interpretation of the slope during an isokinetic fatigue test
Bosquet, L.; Gouadec, K.; Berryman, N. et al

in International Journal of Sports Medicine (2015)

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See detailRelation between global end-diastolic volume and left ventricular end-diastolic volume
Pironet, Antoine ULg; MORIMONT, Philippe ULg; Kamoi, S. et al

in Critical Care (2015), 19(Suppl 1), 175

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See detailCompte rendu de l'ouvrage d'I. Mazzini, Letteratura e medicina nel mondo antico, Rome: Università La Sapienza, 2011
Ricciardetto, Antonio ULg

in Latomus : Revue d'Etudes Latines (2015), 74(1), 280-282

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See detailTowards a full integration of optimization and validation phases: An Analytical-Quality-by-Design approach
Hubert, Cédric ULg; Houari, Sabah ULg; Rozet, Eric ULg et al

in Journal of Chromatography. A (2015)

When using an analytical method, defining an Analytical Target Profile (ATP) focused on quantitative performance represents a key input, and this will drive the method development process. In this context ... [more ▼]

When using an analytical method, defining an Analytical Target Profile (ATP) focused on quantitative performance represents a key input, and this will drive the method development process. In this context, two case studies were selected in order to demonstrate the potential of a Quality-by-Design (QbD) strategy when applied to two specific phases of the method lifecycle: the pre-validation study and the validation step. The first case study focused on the improvement of a Liquid Chromatography (LC) coupled to Mass Spectrometry (MS) stability-indicating method by the means of the QbD concept. The Design of Experiments (DoE) conducted during the optimization step (i.e. determination of the qualitative Design Space (DS)) was performed a posteriori. Additional experiments were performed in order to simultaneously conduct the pre-validation study to assist in defining the DoE to be conducted during the formal validation step. This predicted protocol was compared to the one used during the formal validation. A second case study based on the LC/MS-MS determination of glucosamine and galactosamine in human plasma was considered in order to illustrate an innovative strategy allowing the QbD methodology to be incorporated during the validation phase. An operational space, defined by the qualitative DS, was considered during the validation process rather than a specific set of working conditions as conventionally performed. Results of all the validation parameters conventionally studied were compared to those obtained with this innovative approach for glucosamine and galactosamine. Using this strategy, qualitative and quantitative information were obtained. Consequently, an analyst using this approach would be able to select with great confidence several working conditions within the operational space rather than a given condition for the routine use of the method. This innovative strategy combines both a learning process and a thorough assessment of the risk involved. [less ▲]

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See detailMutation of the iron-sulfur cluster assembly gene IBA57 causes fatal infantile leukodystrophy.
DEBRAY, François-Guillaume ULg; Stumpfig, Claudia; Vanlander, Arnaud V. et al

in Journal of inherited metabolic disease (2015)

Leukodystrophies are a heterogeneous group of severe genetic neurodegenerative disorders. A multiple mitochondrial dysfunctions syndrome was found in an infant presenting with a progressive ... [more ▼]

Leukodystrophies are a heterogeneous group of severe genetic neurodegenerative disorders. A multiple mitochondrial dysfunctions syndrome was found in an infant presenting with a progressive leukoencephalopathy. Homozygosity mapping, whole exome sequencing, and functional studies were used to define the underlying molecular defect. Respiratory chain studies in skeletal muscle isolated from the proband revealed a combined deficiency of complexes I and II. In addition, western blotting indicated lack of protein lipoylation. The combination of these findings was suggestive for a defect in the iron-sulfur (Fe/S) protein assembly pathway. SNP array identified loss of heterozygosity in large chromosomal regions, covering the NFU1 and BOLA3, and the IBA57 and ABCB10 candidate genes, in 2p15-p11.2 and 1q31.1-q42.13, respectively. A homozygous c.436C > T (p.Arg146Trp) variant was detected in IBA57 using whole exome sequencing. Complementation studies in a HeLa cell line depleted for IBA57 showed that the mutant protein with the semi-conservative amino acid exchange was unable to restore the biochemical phenotype indicating a loss-of-function mutation of IBA57. In conclusion, defects in the Fe/S protein assembly gene IBA57 can cause autosomal recessive neurodegeneration associated with progressive leukodystrophy and fatal outcome at young age. In the affected patient, the biochemical phenotype was characterized by a defect in the respiratory chain complexes I and II and a decrease in mitochondrial protein lipoylation, both resulting from impaired assembly of Fe/S clusters. [less ▲]

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See detailMagnetic susceptibility application – a window onto ancient environments and climatic variations
Da Silva, Anne-Christine ULg; Whalen; Hladil et al

Book published by geological Society of London (2015)

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See detailChemostratigraphy of the late devonian Frasnian-Famennian transition in western Canada and Southern China: implications for carbon and nutrient cycling and mass extinction
Whalen; Sliwinski; Payne et al

in Special Publication - Geological Society of London (2015), 414

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See detailQuels medecins pour quelle medecine?
Scheen, André ULg

in Revue medicale de Liege (2015), 70(1), 1-4

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