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See detailLearning in, through, and about participatory technology assessment: The case of nanotechnologies for tomorrow's society (NanoSoc)
Van Oudheusden, Michiel ULg

in Technology Analysis & Strategic Management (2014)

In participatory technology assessment (pTA), technical and nontechnical communities convene to share their views on a sociotechnical challenge, in an attempt to render technology research and development ... [more ▼]

In participatory technology assessment (pTA), technical and nontechnical communities convene to share their views on a sociotechnical challenge, in an attempt to render technology research and development more socially robust. Taking these commitments to transdisciplinary collaboration and co-construction of technology as entry points, this article describes key tensions that emerged in a Flemish pTA project on nanotechnologies, entitled ‘Nanotechnologies for Tomorrow’s Society’ (NanoSoc). The tensions pertain to how the terms of participation were enacted, the potentially conflicting aims embedded in the project’s mission and methods, the various roles initiating pTA researchers (social scientists) assumed throughout the project’s duration, and the deliberative-democratic rationale that sustains pTA frameworks at large. The article is a response to a pressing question posed to the author by pTA professionals, project participants, and policymakers who ask publics to partake in science and technology decision making: Now that NanoSoc is terminated, what can we learn from it? [less ▲]

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See detailReduced chaos expansions with random coefficients in reduced-dimensional stochastic modeling of coupled problems
Arnst, Maarten ULg; Ghanem, Roger; Phipps, Eric et al

in International Journal for Numerical Methods in Engineering (2014), 97

We address the curse of dimensionality in methods for solving stochastic coupled problems with an emphasis on stochastic expansion methods such as those involving polynomial chaos expansions. The proposed ... [more ▼]

We address the curse of dimensionality in methods for solving stochastic coupled problems with an emphasis on stochastic expansion methods such as those involving polynomial chaos expansions. The proposed method entails a partitioned iterative solution algorithm that relies on a reduced-dimensional representation of information exchanged between subproblems to allow each subproblem to be solved within its own stochastic dimension while interacting with a reduced projection of the other subproblems. The proposed method extends previous work by the authors by introducing a reduced chaos expansion with random coefficients. The representation of the exchanged information by using this reduced chaos expansion with random coefficients enables an expeditious construction of doubly stochastic polynomial chaos expansions that separate the effect of uncertainty local to a subproblem from the effect of statistically independent uncertainty coming from other subproblems through the coupling. After laying out the theoretical framework, we apply the proposed method to a multiphysics problem from nuclear engineering. [less ▲]

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See detailCorrection of vitamin D insufficiency with combined strontium ranelate and vitamin D3 in osteoporotic patients.
Rizzoli, R.; Dawson-Hughes, B.; Kaufman, J.-M. et al

in European Journal of Endocrinology (2014), 170(3), 441-50

OBJECTIVE: This study aims to investigate the efficacy and safety of oral fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU daily vs strontium ranelate 2 g daily for correcting vitamin D ... [more ▼]

OBJECTIVE: This study aims to investigate the efficacy and safety of oral fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU daily vs strontium ranelate 2 g daily for correcting vitamin D insufficiency in osteoporosis. DESIGN: A 6-month international, randomized, double-blind, parallel-group, phase 3 study. METHODS: A total of 518 men and postmenopausal women aged >/=50 years with primary osteoporosis (T-score </=-2.5 s.d.) and serum 25-hydroxyvitamin D (25(OH)D) >22.5 nmol/l were included. Patients were allocated to strontium ranelate 2 g/vitamin D3 1000 IU daily (n=413) or strontium ranelate 2 g daily (n=105). The participants received calcium 1 g daily. The primary endpoint was serum 25(OH)D at last post-baseline evaluation during 3 months. RESULTS: Both groups were comparable at baseline. Mean baseline of 25(OH)D was 44.1+/-14.6 nmol/l. After 3 months, the percentage of patients with 25(OH)D >/=50 nmol/l was higher with strontium ranelate/vitamin D3 vs strontium ranelate (84 vs 44%, P<0.001; adjusted between-group odds ratio=6.7; 95% CI, 4.2-10.9). The efficacy of the fixed-dose combination on 25(OH)D was maintained at 6 months (86 vs 40%, P<0.001). Mean 25(OH)D was 65.1 and 49.5 nmol/l, respectively, after 3 months and 66.9 and 45.4 nmol/l after 6 months. Physical performance improved in both groups. Falls were 17 and 20% in the strontium ranelate/vitamin D3 and strontium ranelate groups respectively. Parathyroid hormone levels were inversely correlated with 25(OH)D. No clinically relevant differences in safety were observed. CONCLUSIONS: This study confirms the efficacy and safety of fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU for correction of vitamin D insufficiency in osteoporotic patients. [less ▲]

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See detailLA RADIOTHÉRAPIE MODERNE PRÉ- OU POSTOPERATOIRE POUR LES SARCOMES DES TISSUS MOUS DES MEMBRES
COUCKE, Philippe ULg; JANVARY, Zsolt Levente ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 53-57

Les sarcomes des tissus mous sont des cancers rares qui nécessitent une approche multidisciplinaire, au niveau diagnostique et en ce qui concerne le traitement et le suivi. La chirurgie (exérèse tumorale ... [more ▼]

Les sarcomes des tissus mous sont des cancers rares qui nécessitent une approche multidisciplinaire, au niveau diagnostique et en ce qui concerne le traitement et le suivi. La chirurgie (exérèse tumorale large en marges saines) est la base du traitement. Le risque de récidive étant élevé pour cer - tains sous-groupes de patients, une radiothérapie adjuvante est le plus souvent préconisée. Classiquement, ce traitement était donné en postopératoire, mais une radiothérapie pré - opératoire, dite «néo-adjuvante», offre un certain nombre d’avantages. Nous discutons également l’adaptation de la radiothérapie à la chirurgie et vice versa, ainsi que le parcours classique d’un patient traité pour un sarcome des tissus mous. Finalement, quelques évolutions techniques futures sont briè - vement présentées. [less ▲]

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See detailMyeloperoxidase and its products in synovial fluid of patients with treated or untreated rheumatoid arthritis.
Nzeusseu Toukap, A.; Delporte, C.; Noyon, C. et al

in Free radical research (2014), 48(4), 461-5

Abstract Objective. Plasma and synovial myeloperoxidase (MPO) and its products were strongly associated with osteoarthritis (OA) and rheumatoid arthritis (RA). In addition, it is well known that there is ... [more ▼]

Abstract Objective. Plasma and synovial myeloperoxidase (MPO) and its products were strongly associated with osteoarthritis (OA) and rheumatoid arthritis (RA). In addition, it is well known that there is a link between oxidative stress and cytokines. The present study aims at investigating the link between synovial MPO (and its products), interleukin (IL)-18, which is involved in the degradation of articular cartilage in RA, and IL-8, which is involved in recruitment and activation of neutrophils during inflammation. Effects of the treatment of RA on the biological parameters were also investigated. Methods. Patients (n = 105) were studied including 39 patients with OA, 33 with RA and 33 with RA receiving a specific treatment. Disease activity score (DAS-28) was calculated whereas MPO antigen/activity, neutrophils, chloro-tyrosine (Cl-Tyr), homocitrulline (Hcit), IL-8, and IL-18 were measured in synovial fluid (SF) and CRP was measured in serum. Results. DAS-28 and CRP levels were not significantly different between groups. MPO activity, and MPO, Cl-Tyr, and Hcit levels were significantly higher in SF of RA patients than OA patients. MPO specific activity (MPO activity/antigen ratio) was significantly lower in treated than in untreated RA patients as was IL-8. MPO activity and concentration were correlated with IL-8 and IL-18 in untreated but not in treated RA patients. Conclusions. MPO level is related to IL-8 and IL-18 levels in untreated RA patients. A link has been shown between treatment and decrease of IL-8, MPO specific activity and Hcit in SF. The causal role of MPO in SF inflammation and how treatment can affect MPO specific activity need further investigations. [less ▲]

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See detailEstimation of the error density in a semiparametric transformation model
Colling, Benjamin; Heuchenne, Cédric ULg; Samb, Rawane et al

in Annals of the Institute of Statistical Mathematics (2014)

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See detailINDICATIONS D’UN TRAITEMENT DE RADIOTHERAPIE LOCALE APRES PROSTATECTOMIE RADICALE
HERMESSE, Johanne ULg; WERENNE, Xavier ULg; PHILIPPI, Sven ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 29-31

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See detailLA CURIETHÉRAPIE PROSTATIQUE PAR IMPLANTS PERMANENTS D'IODE 125- résultats après 10 ans d'expérience au CHU de Liège
HERMESSE, Johanne ULg; NICKERS, Philippe; REUL, Olivier et al

in Revue Médicale de Liège (2014), 69(Supp 1), 32-36

La curiethérapie prostatique, par implantation per - manente de grains radioactifs d’iode 125, offre aux patients atteints d’un cancer localisé de la prostate une alternative attractive au traitement ... [more ▼]

La curiethérapie prostatique, par implantation per - manente de grains radioactifs d’iode 125, offre aux patients atteints d’un cancer localisé de la prostate une alternative attractive au traitement chirurgical. La survie globale et la survie sans récidive biochimique y sont superposables, mais le profil de toxicité est différent. La plus grande opportunité de préservation de la fonction érectile, la diminution du risque d’incontinence et l’hospitalisation de jour peuvent être inté - ressantes pour le patient optant pour la curiethérapie. Par contre, la présence d’un syndrome obstructif urinaire de départ devrait orienter préférentiellement vers un traitement chirurgical. Un patient doit pouvoir faire un choix éclairé entre ces différentes possibilités thérapeutiques moyennant une information transparente et complète. Dans cet exposé, nous relatons notre expérience en curiethérapie par implants permanents d’iode 125. La survie globale, la survie libre sans récidive biochimique à long terme et la toxicité enregistrée sont similaires à celles décrites dans la littérature. [less ▲]

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See detailPlant Water Uptake in Drying Soils
Lobet, Guillaume ULg; Couvreur, Valentin; Meunier, Félicien et al

in Plant Physiology (2014), in press

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See detailConcomitant manipulation of NMDA- and AMPA-receptors to produce pro-cognitive drug effects
Vignisse, Julie ULg; Steinbusch, Harry W.M.; Grigoriev, Vladimir et al

in European Neuropsychopharmacology (2014), 24

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA ... [more ▼]

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA receptors or the potentiation of AMPA receptors is well documented to result in memory enhancement. Here, we compared the efficacy of the low-affinity NMDA receptor blocker memantine or the positive modulator of AMPA receptor QXX (in C57BL/6J at 1 or 5 mg/kg, ip) with new derivatives of isothiourea (0.5-1 mg/kg, ip) that have bifunctional efficacy. Low-affinity NMDA blockade by these derivatives was achieved by introducing greater flexibility into the molecule, and AMPA receptor stimulation was produced by a sulfamide-containing derivative of isothiourea. Contextual learning was examined in a step-down avoidance task and extinction of contextual memory was studied in a fear-conditioning paradigm. Memantine enhanced contextual learning while QXX facilitated memory extinction; both drugs were effective at 5 mg/kg. The new derivative IPAC-5 elevated memory scores in both tasks at the dose 0.5 mg/Kg and exhibited the lowest IC50 values of NMDA receptor blockade and highest potency of AMPA receptor stimulation. Thus, among the new drugs tested, IPAC-5 plicated the properties of memantine and QXX in one administration with increased potency. Our data suggest that a concomitant manipulation of NMDA- and AMPA-receptors results in pro-cognitive effects and supports the concept bifunctional drug therapy as a promising strategy to replace monofunctional therapies with greater efficacy and improved compliance. [less ▲]

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See detailThe Threshold Photoelectron Spectrum of Geminal Chloro-Fluoro-ethene (1,1-C2H2FCl) isomer. Experiment and Theory.
Locht, Robert ULg; Dehareng, Dominique ULg; Leyh, Bernard ULg

in Journal of Physics : B Atomic Molecular & Optical Physics (2014), 47(8), 0851019

The threshold photoelectron spectrum (TPES) of 1,1-C2H2FCl has been measured for the first time using synchrotron radiation. It has been compared to the HeI photoelectron spectrum (PES) obtained earlier ... [more ▼]

The threshold photoelectron spectrum (TPES) of 1,1-C2H2FCl has been measured for the first time using synchrotron radiation. It has been compared to the HeI photoelectron spectrum (PES) obtained earlier [Tornow G. et al., Chem.Phys. 146 115 (1990)]. Eight photoelectron bands have been observed at 10.22 eV, 12.45 eV, 13.28 eV, 14.29 eV, 14.99 eV, 17.12 eV, 17.67 eV, and at 20.23 eV successively. Only the first three bands exhibit a rich and extensive vibrational structure. Their adiabatic ionization energies are measured and a detailed vibrational analysis is presented. The assignments of the electronic bands and of the vibrational wavenumbers were made by using ab initio quantum chemical calculations. These allowed us to provide the MO description of the eight electronic states in terms of ionization and double excitation. The good correlation between predicted vibrational wavenumbers and the experimental values provides a strong basis for the assignment of all the vibrational structures. [less ▲]

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See detailCognitive and neuroimaging evidence of impaired interaction between Self and memory in Alzheimer’s disease.
Genon, Sarah ULg; Genon, Sarah ULg; Bahri, Mohamed Ali ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 51

In human cognition, self and memory processes strongly interact, as evidenced by the memory advantage for self-referential materials (Self Reference Effect (SRE) and Self Reference Recollection Effect ... [more ▼]

In human cognition, self and memory processes strongly interact, as evidenced by the memory advantage for self-referential materials (Self Reference Effect (SRE) and Self Reference Recollection Effect (SRRE)). The current study examined this interaction at the behavioural level and its neural correlates in patients with Alzheimer’s disease (AD). Healthy older controls (HC) and AD patients performed trait-adjectives judgements either for self-relevance or for other-relevance (encoding phase). In a first experiment, the encoding and subsequent yes-no recognition phases were administrated in an MRI scanner. Brain activation as measured by fMRI was examined during self-relevance judgements and anatomical images were used to search for correlation between the memory advantage for self-related items and grey matter density (GMD). In a second experiment, participants described the retrieval experience that had driven their recognition decisions (familiarity vs. recollective experience). The behavioural results revealed that the SRE and SRRE were impaired in AD patients compared to HC participants. Furthermore, verbal reports revealed that the retrieval of self-related information was preferentially associated with the retrieval of contextual details, such as source memory in the HC participants, but less so in the AD patients. Our imaging findings revealed that both groups activated the medial prefrontal cortex (MPFC) at encoding during self-relevance judgments. However, the variable and limited memory advantage for self-related information was associated with GMD in the lateral prefrontal cortex in the AD patients, a region supporting high-order processes linking self and memory. These findings suggest that even if AD patients engage MPFC during self-referential judgments, the retrieval of self-related memories is qualitatively and quantitatively impaired in relation with altered high-order processes in the lateral PFC. [less ▲]

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See detailLa contribution des lobes frontaux au fonctionnement exécutif
Collette, Fabienne ULg

Conference (2014)

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See detailContinuity amid change in India’s political economy: from “socialist” to “neoliberal” India.
Maiorano, Diego ULg

in Economic and Political Weekly (2014)

The aim of this paper is to show that the social coalition that benefited from India’s central government’s economic policies remained unchanged between the pre and post economic reforms periods. More ... [more ▼]

The aim of this paper is to show that the social coalition that benefited from India’s central government’s economic policies remained unchanged between the pre and post economic reforms periods. More specifically, this paper will argue that the economic policies promoted by the central government between 1980 and 2004 – irrespective of the political party heading the Cabinet – mostly benefited the middle class and the corporate sector, while the poor and the rural world were clearly relegated to a secondary position in the governments’ policy priorities. The paper will highlight six important lines of continuity in India’s economic policy and will argue that if we look at who the “winner” and the “losers” of these policy processes are, the economic reforms of the early 1990s do not separate two different phases of India’s development path. From this point of view the election of the United Progressive Alliance (UPA) government in 2004 might constitute a more important break with the past. [less ▲]

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See detailSocial Security and Family Support
Leroux, Marie Louise; Pestieau, Pierre ULg

in Canadian Journal of Economics (2014), 47(1), 115-143

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See detailEndogenous Altruism, Redistribution, and Long Term Care
Pestieau, Pierre ULg; Cremer, Helmuth; Gahvari, Firouz

in B.E. Journal of Economic Analysis & Policy (2014), 14(2), 499-524

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See detailUnited but (un)equal: human capital, probability of divorce, and the marriage contract
Cremer, Helmuh; Pestieau, Pierre ULg; Roeder, Kerstin

in Journal of Population Economics (2014)

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