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See detailSubstrate Induced Strain Field in FeRh Epilayers Grown on Single Crystal MgO (001) Substrates
Barton, C. W.; Ostler, Thomas ULg; Huskisson, D. et al

in Scientific Reports (2017), 7

Equi-atomic FeRh is highly unusual in that it undergoes a rst order meta-magnetic phase transition from an antiferromagnet to a ferromagnet above room temperature (Tr ≈ 370 K). This behavior opens new ... [more ▼]

Equi-atomic FeRh is highly unusual in that it undergoes a rst order meta-magnetic phase transition from an antiferromagnet to a ferromagnet above room temperature (Tr ≈ 370 K). This behavior opens new possibilities for creating multifunctional magnetic and spintronic devices which can utilise both thermal and applied eld energy to change state and functionalise composites. A key requirement in realising multifunctional devices is the need to understand and control the properties of FeRh in the extreme thin lm limit (tFeRh < 10 nm) where interfaces are crucial. Here we determine the properties of FeRh lms in the thickness range 2.5–10 nm grown directly on MgO substrates. Our magnetometry and structural measurements show that a perpendicular strain eld exists in these thin films which results in an increase in the phase transition temperature as thickness is reduced. Modelling using a spin dynamics approach supports the experimental observations demonstrating the critical role of the atomic layers close to the MgO interface. [less ▲]

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See detailEnergy assessment of suburban neighborhoods : insights from Wallonia and perspectives for a suburban renewal
Marique, Anne-Françoise ULg

Conference (2017, April 12)

The aim of the paper is to present a method to assess the energy efficiency of suburban areas, taking into account both energy efficiency of buildings and the impacts of location and urban form on the ... [more ▼]

The aim of the paper is to present a method to assess the energy efficiency of suburban areas, taking into account both energy efficiency of buildings and the impacts of location and urban form on the energy balance of suburban areas. The method is applied to the Walloon region of Belgium and perspectives for a sustainable suburban renewal are proposed. [less ▲]

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See detailAzacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects
Ehx, Grégory ULg; Fransolet, Gilles ULg; De Leval, Laurence et al

in Oncoimmunology (2017)

The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading ... [more ▼]

The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Treg). Here, we investigated the impact of AZA on xenogeneic graft-versus-host disease (xGVHD) and graft-versus-leukemia effects in a humanized murine model of transplantation (human PBMCs-infused NSG mice), and described the impact of the drug on human T cells in vivo. We observed that AZA improved both survival and xGVHD scores. Further, AZA significantly decreased human T-cell proliferation as well as IFN-γ and TNF-α serum levels, and reduced the expression of GRANZYME B and PERFORIN 1 by cytotoxic T cells. In addition, AZA significantly increased Treg frequency through hypomethylation of FOXP3i1 as well as increased Treg proliferation. The later was subsequent to higher STAT5 signaling in Treg from AZA-treated mice, which resulted from higher IL-2 secretion by conventional T cells from AZA-treated mice itself secondary to demethylation of the IL-2 gene promoter by AZA. Importantly, Tregs harvested from AZA-treated mice were suppressive and stable over time since they persisted at high frequency in secondary transplant experiments. Finally, graft-versus-leukemia effects (assessed by growth inhibition of THP-1 cells, transfected to express the luciferase gene) were not abrogated by AZA. In summary, our data demonstrate that AZA prevents xGVHD without abrogating graft-versus-leukemia effects. These findings could serve of basis for further studies of GVHD prevention by AZA in acute myeloid leukemia patients offered an allogeneic transplantation. [less ▲]

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See detailDocking and molecular dynamics simulations of the Fyn-SH3 domain with free and phospholipid bilayer-associated 18.5-kDa myelin basic protein (MBP) – Insights into a non-canonical and fuzzy interaction
Bessonov, Kyrylo ULg; Harauz, George; Vassall, Kenrick

in Proteins (2017)

The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence ... [more ▼]

The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence numbering), were studied in silico via docking and molecular dynamics over 50-ns trajectories. The results show that interaction between the two proteins is energetically favorable and heavily-dependent on the MBP proline-rich region (P93-P98) in both aqueous and membrane environments. In aqueous conditions, the xα2-peptide/Fyn-SH3 complex adopts a “sandwich”-like structure. In the membrane context, the xα2-peptide interacts with the Fyn-SH3 domain via the proline-rich region and the β-sheets of Fyn-SH3, with the latter wrapping around the proline-rich region in a form of a clip. Moreover, the simulations corroborate prior experimental evidence of the importance of upstream segments beyond the canonical SH3-ligand. This study thus provides a more-detailed glimpse into the context-dependent interaction dynamics and importance of the β-sheets in Fyn-SH3 and proline-rich region of MBP. [less ▲]

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See detailParacervix Parametrium
Bonnet, Pierre ULg

Scientific conference (2017, April 11)

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See detailQuaternary prevention library and resources (QP library)
Pizzanelli, Miguel; Lavalle, Ricardo; Jamoulle, Marc ULg

Learning material (2017)

Collaborative Database on Quaternary Prevention Resources and References. Base de datos colaborativa de recursos y referencias bibliográficas sobre Prevención Cuaternaria. Base de Dados Colaborativa de ... [more ▼]

Collaborative Database on Quaternary Prevention Resources and References. Base de datos colaborativa de recursos y referencias bibliográficas sobre Prevención Cuaternaria. Base de Dados Colaborativa de Recursos e Referências sobre Prevenção Quaternária. Réseau collaboratif de ressources et de références en matière de Prévention du Quaternaire [less ▲]

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See detailThe role of natural hazards and human activities on change of sedimentation patterns: The case of Lake Yamanaka (Fuji Five Lakes, Japan)
Lamair, Laura ULg; Hubert, Aurelia ULg; El Ouahabi, Meriam ULg et al

Conference (2017, April 10)

The last eruption of Mt Fuji (Japan) occurred in A.D. 1707. The eruption lasted 16 days from 16 December 1707 to 1 January 1708 (Tsuya, 1955) and 1.8 km3 of volcanic materials were ejected in total ... [more ▼]

The last eruption of Mt Fuji (Japan) occurred in A.D. 1707. The eruption lasted 16 days from 16 December 1707 to 1 January 1708 (Tsuya, 1955) and 1.8 km3 of volcanic materials were ejected in total (Miyaji et al., 2011). Lake Yamanaka, a very shallow lake (max. 14. 3 m depth) located at the foot of the east-north-eastern flank of Mt Fuji, was heavily impacted by the eruption. A thick scoria layer entirely covered the catchment of Lake Yamanaka. The thickness of the deposit varies from 5 to 37 cm around Lake Yamanaka and reaches up to 149 cm at the south-west extremity of the catchment (Miyaji et al., 2011). In order to study the influence of Hoei eruption on Lake Yamanaka, 5 gravity cores were taken during the 2014 QuakeRecNankai campaign. The Hoei scoria was present at the bottom of the one core and in the core catcher of the four other cores. High resolution magnetic susceptibility, XRD, XRF, LOI, C/N and 210Pb/137Cs analyses were performed on the gravity cores. The results shows three distinct periods of sedimentation: (1) From Hoei eruption to A.D. 1900; (2) From A.D. 1900 to A.D. 1990; (3) From A.D. 1990 to A.D. 2014. The first period is characterized by a very low sedimentation rate (~0.07 cm/yr). During this period, the sediments of the catchment were trapped below the thick Hoei scoria layer. However, peaks of terrigenous input are recorded. We link such detrical signals with violent typhoons that hit the Fuji Five Lakes region. The water from the heavy rains percolated through the porous thick scoria layer and saturated it. As a result, surface runoffs carried the sediments from the catchment into Lake Yamanaka. The second period (from A.D. 1900 to A.D. 1990) is defined by an increase of the sedimentation rate (~0.16 cm/yr). The development of soil and the agriculture (e.g. pastureland, rice field, mulberry plantations) reduced the impact of Hoei scoria. The terrigenous inputs are higher than previously but remained more or less constant during this period of time. As the thickness of the scoria layer is partially reduced or covered by new soil, rains triggered by smaller typhoons could drain the sediments from watershed and transport them into the lake. The most recent period representing the last 27 years is characterized by a very high sedimentation rate (~1.036 cm/yr). The transition between period 2 and period 3 corresponds to the development of mass tourism and the urbanization around Lake Yamanaka. It is marked by an increasing of atmospheric pollution (Pb, Zn). In the upper part of the cores, a peak of 137Cs is observed. Such peak is related to cesium fall-out after Fukushima incident in 2011. In addition to the fingerprint of human impact, the lake also record a terrigenous signal related to the 2007 Fitow typhoon which provoked damage in the area. This study highlights the influence of eruptions and typhoons on the sedimentation of Lake Yamanaka. In the present day, the sedimentation recovery after a major eruption is accelerated by human activity. References: Miyaji N., Kan'no A., Kanamaru T., Mannen K. 2011. High-resolution reconstruction of the Hoei eruption (AD 1707) of Fuji volcano, Japan. Journal of Volcanology and Geothermal Research 207, 113–129. Tsuya, H. 1955. Geological and petrological studies of volcano, Fuji, V.: 5. on the 1707 eruption of Volcano Fuji. Bulletin of the Earthquake Research Institute 33, 341–383. [less ▲]

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See detailPelvic anatomy, a constructive approach
Bonnet, Pierre ULg

Scientific conference (2017, April 10)

Detailed reference viewed: 13 (1 ULg)
See detailPelvic ureter
Bonnet, Pierre ULg

Scientific conference (2017, April 10)

Detailed reference viewed: 13 (1 ULg)
See detailTopographic anatomy of the pelvic vessels
Bonnet, Pierre ULg

Scientific conference (2017, April 10)

Detailed reference viewed: 12 (1 ULg)
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See detailUnguiculin A and Ptilomycalins E-H, Antimalarial Guanidine Alkaloids from the Marine Sponge Monanchora unguiculata.
Campos, Pierre-Eric; Wolfender, Jean-Luc; Quieroz, Emerson F. et al

in Journal of Natural Products (2017), 80

Chemical study of the CH2Cl2-MeOH (1:1) extract from the sponge Monanchora unguiculata collected in Madagascar highlighted five new compounds, one acyclic guanidine alkaloid, unguiculin A (1) and four ... [more ▼]

Chemical study of the CH2Cl2-MeOH (1:1) extract from the sponge Monanchora unguiculata collected in Madagascar highlighted five new compounds, one acyclic guanidine alkaloid, unguiculin A (1) and four pentacyclic alkaloids, ptilomycalins E-H (2-5), along with four known compounds: crambescidin 800 (6) and crambescidin 359 (7), crambescidic acid (8), and fromiamycalin (9). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. The new ptilomycalin E (2) and the mixture of the new ptilomycalins G (4) and H (5) showed promising cytotoxicity against KB cells with IC50 values of 0.85 and 0.92 μM, respectively. Ptilomycalin F (3) and fromiamycalin (9) exhibited promising activity against Plasmodium falciparum with IC50 values of 0.23 and 0.24 μM, respectively [less ▲]

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See detailRevista "Esfera pública discursiva"
Becerra Mayor, David ULg

in Esfera pública discursiva (2017), 1

Número 1 de la revista de crítica e información literaria realizada por las y los estudiantes de "Stylistique et critique de l’espagnol moderne" del curso 2016-2017, de la Université de Liège.

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See detailTowards Knowledge management in General Practice & Family Medicine; Guide to the indexing of master thesis.
Jamoulle, Marc ULg

Learning material (2017)

The Francophone Coordination Center for Training in General Practice (CCFFMG) (www.ccffmg.be)(French) is in charge of organizing the public release of the End-of-Study works (Master thesis) in General ... [more ▼]

The Francophone Coordination Center for Training in General Practice (CCFFMG) (www.ccffmg.be)(French) is in charge of organizing the public release of the End-of-Study works (Master thesis) in General Practice/Family Medicine (GP/FM) . This work is carried out at the end of the Master of Specialty of the Departments of General Practice of the Free University of Brussels (ULB), the Catholic University of Louvain (UCL) and the University of Liège (ULg). A dedicated website (www.mgtfe.be) offers an online copywriting guide. This site provides also a description and instruction manual for a GP/FM indexing system discussed in this document. This experimental system, based on the assembly of the International Classification of Primary Care, second version (ICPC-2), and a new contextual classification called Q-Codes version 2.5 is intended to help the manual indexation of the Master Thesis. The package, called Core Content Classification in GP/FM (3CGP), is now available in 8 languages (en-fr-nl-es-pt-vi-ko-tr) on the multilingual web site of Department of Medical Information and Medical Informatics (B2IM) of the University of Rouen (www.hetop.eu/q) together with a companion site (http://3cgp.woncaeurope.org) (in English). Family physician will be asked to choose a number of proposed codes to index their jobs at the time of online filing. The publishing site will be equipped with a search module based on the 3CGP indexing system. An evaluation of the system of indexing by the users is organized. [less ▲]

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See detailLe sens de la vue et le sens de la marche. Déambulation et signification dans l'œuvre de Marc-Antoine Mathieu
Belloi, Livio ULg

Conference (2017, April 08)

Dans la foulée de l'ouvrage publié par Ian Hague ("Comics and the Senses", Routledge, 2014), cette conférence aborde la double question du sens et des sens dans le domaine de la bande dessinée ... [more ▼]

Dans la foulée de l'ouvrage publié par Ian Hague ("Comics and the Senses", Routledge, 2014), cette conférence aborde la double question du sens et des sens dans le domaine de la bande dessinée contemporaine, en se concentrant d'abord sur l'œuvre de Marc-Antoine Mathieu. Chemin faisant, l'œuvre de Mathieu se voit mise en regard avec "La Différence invisible" (2016) de Julie Dachez et Mademoiselle Caroline. [less ▲]

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See detailModellierung der chemischen Kinetik. Entwicklung eines Verständnisses auf molekularer Ebene anhand gezielter Versuche
Nihant, Brigitte ULg; Karous, Hamad ULg; Leyh, Bernard ULg

Conference (2017, April 08)

Damit die Lernenden als zukünftige verantwortliche Bürger eine authentische Vision der Wissenschaft und ihrer Grenzen gewinnen, heben die Rahmen- und Lehrpläne immer mehr die Notwendigkeit hervor, sie mit ... [more ▼]

Damit die Lernenden als zukünftige verantwortliche Bürger eine authentische Vision der Wissenschaft und ihrer Grenzen gewinnen, heben die Rahmen- und Lehrpläne immer mehr die Notwendigkeit hervor, sie mit wissenschaftlichen Modellen und derer Erarbeitung vertraulich zu machen. Die chemische Kinetik bietet einen günstigen Rahmen, solche Modellierungskompetenzen zu fördern. Das didaktische Ziel kann wie folgt zusammengefasst werden: Eine chemische Reaktion als das Resultat wirksamer Stöße zwischen Molekülen beschreiben, um den Einfluss verschiedener experimenteller Faktoren auf die Reaktionsgeschwindigkeit zu erklären. Dies verlangt eine Modellierung, bei der die vier Ebenen (empirisch, makroskopisch, symbolisch, mikroskopisch) des didaktischen Tetraeders von Kermen und Méheut (2009) (Chemistry Education Research and Practice, 10, 24-34) erörtert werden. In diesem Vortrag werden verschiedene Aktivitäten (z.B. Versuche über molekulare Diffusion, Einführung des Begriffes des Übergangszustandes anhand angepasster, selbstgebauter Molekülmodelle) präsentiert und didaktisch ausgewertet. Großes Gewicht wird darauf gelegt, dass die Lernenden sich der erklärenden Rolle der Modelle bewusst werden, dass ihre Autonomie gefördert wird, indem der Schwierigkeitsgrad der sogenannten Zone der nächsten Entwicklung (Wygotski) entspricht, und dass das vorgestellte didaktische Modellierungsverfahren die Denkweise der Wissenschaftler reflektiert. [less ▲]

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See detailSurgical management of ectopic ureters in dogs: clinical outcome and prognostic factors for long-term continence
Noël, Stéphanie ULg; Claeys, Stéphanie ULg; Hamaide, Annick ULg

in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (2017)

Detailed reference viewed: 15 (3 ULg)
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See detailAnalysis of Migration in a Multi-Risk Context: Case of Bujumbura/Burundi
Nibigira, Léonidas ULg; Ozer, Pierre ULg; Havenith, Hans-Balder ULg

in MAIER, ROBIN; REVELL, MARK (Eds.) THE AMERICAN ASSOCIATION OF GEOGRAPHERS, 2017 Annual Meeting, April 5 - 9, 2017 Boston, Massachusetts / PROGRAM (2017, April 08)

Human mobility affects land use and human density distribution. Unfortunately, this rarely takes into account the real and potential changes induced by hazards on the natural systems. Thus, migration and ... [more ▼]

Human mobility affects land use and human density distribution. Unfortunately, this rarely takes into account the real and potential changes induced by hazards on the natural systems. Thus, migration and natural hazards should be constantly analyzed through cross-sectional and global studies to reduce disastrous consequences resulting from their mutual interactions. In a multi-risk and demographic sprawl context, the study focused on the cross-analysis of human density and natural hazards in Bujumbura. The results show that migration of people should ideally be guided by knowledge of the area's sensitivity to natural hazards, taking into account other parameters such as hazards susceptibility maps and production opportunities. While the migration of people toward overcrowded centers constitutes a big challenge, it is an important asset when it concerns areas in need of manpower. It also allows the balance in relieving saturated areas, reducing human pressure on the environment. Therefore, there is a need that policymakers comply with those aspects, finding the right balance for a better situation. [less ▲]

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See detailL'excuse est devenue une arme en politique
Grandjean, Geoffrey ULg

Article for general public (2017)

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See detailCovering codes
Vandomme, Elise ULg

Conference (2017, April 07)

Covering problems are traditional issues in mathematics. For instance, a natural covering problem in the n-dimensional euclidean space is to ask for the minimal number of identical spheres needed to cover ... [more ▼]

Covering problems are traditional issues in mathematics. For instance, a natural covering problem in the n-dimensional euclidean space is to ask for the minimal number of identical spheres needed to cover a large volume. The same issues can be considered in graphs. The corresponding covering problem is to determine the minimal number of r-balls that can be placed in such a way that every vertex of the graph is contained in at least one of them. In this talk, we consider coverings that satisfy special multiplicity conditions, called (r,a,b)-covering codes. These codes generalizes the notion of perfect codes in graphs that correspond to tilings of the graph with r-balls. We focus our attention on the multidimensional infinite grid and discuss the periodicity of (r,a,b)-codes in this case. Finally, for the dimension 2, we determine the possible values of the constant a and b. [less ▲]

Detailed reference viewed: 15 (2 ULg)