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See detailFROM METABOLOMICS STUDY OF AGE RELATED MACULAR DEGENERATION (AMD) TO THE DEVELOPMENT OF NEW PDK INHIBITORS
Arslan, Deniz ULg; Schoumacher, Matthieu ULg; Pirotte, Bernard ULg et al

in Arslan, Deniz (Ed.) Gazi Pharma Symposium Abstract Book (2015, November 12)

Metabolomics is one of the most recent technologies in the Omics sciences defined as “the comprehensive characterization of small molecules (called metabolites) in different biological samples.” This ... [more ▼]

Metabolomics is one of the most recent technologies in the Omics sciences defined as “the comprehensive characterization of small molecules (called metabolites) in different biological samples.” This methodology can be applied in many areas, such as biomarker discovery, clinical studies, drug efficacy and toxicity evaluation, diagnostic tools, quality control or drug discovery. Its capability to extract biochemical information associated with a cellular or biological system makes this technique a powerful tool for Medicinal Chemistry. In this work, we present a 1H NMR metabolomics study applied to therapeutic target discovery. Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly population of industrialized countries. This blindness results from the deterioration of the macula, a small part of the retina specialized for the high-acuity vision. Exudative AMD, called “wet”, is characterized by the formation of new blood vessels growing under the retina according to a process named choroidal neovascularization (CNV). Currently, the aetiology and pathogenesis of AMD remain unclear. Nevertheless, a recent metabolomics study performed on the serum of “wet” AMD patients and on a CNV murine model, that mimics the effect of “wet” AMD, have demonstrated that lactate level is clearly involved in the severity of the pathology as well as the relationship between lactate, CNV and AMD. According to this result, we suggest a new therapeutic approach of AMD based on the normalization of blood lactate level. The modulation of the lactate plasma concentration by treatment of the animals with synthetic compounds and more specifically Pyruvate Dehydrogenase Kinase (PDK) inhibitors significantly decrease the CNV. Starting from these results, development of new PDK inhibitors could open the way to innovative treatment opportunities in AMD disease. [less ▲]

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See detailL’antonymie. Définition et fonctions discursives
Steffens, Marie ULg

Scientific conference (2015, November 12)

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See detailFarms for Future? Contribution of agroecological farms to the delivery of ecosystem services
Boeraeve, Fanny ULg; Dendoncker, Nicolas; Dufrêne, Marc ULg et al

Conference (2015, November 12)

In the western part of the Hainaut province in Belgium, a dynamic network of several farms intentionally incorporates biodiversity within their practices and across multiple scales. While it is suggested ... [more ▼]

In the western part of the Hainaut province in Belgium, a dynamic network of several farms intentionally incorporates biodiversity within their practices and across multiple scales. While it is suggested that such diversification of agricultural practices supports ecological processes in turn favoring biomass production and providing other ecosystem services (ES) to society, few studies have actually attested this fact. A recent review by Kremen and Miles (2012) comparing the provision of 12 ES in organic and conventional systems concludes that ‘integrated whole-system studies of the influence of different farming practices on multiples ES are critically needed’; a conclusion confirmed by the few existing farm-scale ES assessments. This research’s goal is to fulfill this gap by providing comprehensive knowledge about the socio-ecological performance of such systems. To achieve this, we rely on the tool of integrated ES assessment, which includes both a biophysical and a social valuation. Such value-pluralism is of high relevance in agricultural contexts, where multiple values are required to capture the diversity of needs and wants that nature can contribute to fulfill for society and individuals. With the aim to get better insights into societal values, a ‘field thesis committee’ was launched. This latter one includes local farmers and citizens who are consulted throughout the research. For instance, at the start of the project, a participative ES selection was organized to guide the research towards ES important in the eyes of local stakeholders. The presentation first introduces the innovative multi-actor and multi-disciplinary approach developed in this project. Preliminary results are then presented and interpreted. We believe our approach can bring significant contribution to body of knowledge on the reconciliation of social and environmental expectancies. [less ▲]

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See detailLa 3D, son histoire et son actualité à l'ULg
Verly, Jacques ULg

Conference given outside the academic context (2015)

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See detailHow lesbian parenting leads to reassess bisexuality and thirdness
Naziri, Despina ULg

Conference given outside the academic context (2015)

Using data from a clinical psychoanalytic study of lesbian couples undertaking Artificial Insemination by Donor (AID), the conference explores how female same sex parenting is related to the notion of the ... [more ▼]

Using data from a clinical psychoanalytic study of lesbian couples undertaking Artificial Insemination by Donor (AID), the conference explores how female same sex parenting is related to the notion of the third and to the concept of bisexuality by focusing on two specific themes: the position attributed to the donor, who is unknown to the lesbian parents, as well as the process of evolution and attribution of the place of each mother in the lesbian couple. Our aim is to highlight the complexity of the issue of the third in same-sex parenting by analysing fantasised constructions surrounding the image of the anonymous donor, the impact of the medical act of insemination on the women’s psychic economy and the search for other promising bases for triangulation. We would also like to demonstrate the complexity of the issue of bisexuality: although the project of having a child mobilizes a wide range of identifications for both parental imagos, the whole procedure leading to AID shakes up omnipotent sexual fantasies, mobilizes the fantasy of the heterosexual primal scene and makes necessary further elaboration of the feminine side of bisexuality in the context of gender differences. [less ▲]

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See detailWood Specific Gravity Variations and Biomass of Central African Tree Species: The Simple Choice of the Outer Wood
Bastin, Jean-François ULg; Fayolle, Adeline ULg; Tarelkin, Yegor et al

in PLoS ONE (2015)

Context: Wood specific gravity is a key element in tropical forest ecology. It integrates many aspects of tree mechanical properties and functioning and is an important predictor of tree biomass. Wood ... [more ▼]

Context: Wood specific gravity is a key element in tropical forest ecology. It integrates many aspects of tree mechanical properties and functioning and is an important predictor of tree biomass. Wood specific gravity varies widely among and within species and also within individual trees. Notably, contrasted patterns of radial variation of wood specific gravity have been demonstrated and related to regeneration guilds (light demanding vs. shade-bearing). However, although being repeatedly invoked as a potential source of error when estimating the biomass of trees, both intraspecific and radial variations remain little studied. In this study we characterized detailed pith-to-bark wood specific gravity profiles among contrasted species prominently contributing to the biomass of the forest, i.e., the dominant species, and we quantified the consequences of such variations on the biomass. Methods: Radial profiles of wood density at 8% moisture content were compiled for 14 dominant species in the Democratic Republic of Congo, adapting a unique 3D X-ray scanning technique at very high spatial resolution on core samples. Mean wood density estimates were validated by water displacement measurements. Wood density profiles were converted to wood specific gravity and linear mixed models were used to decompose the radial variance. Potential errors in biomass estimation were assessed by comparing the biomass estimated from the wood specific gravity measured from pith-to-bark profiles, from global repositories, and from partial information (outer wood or inner wood). Results: Wood specific gravity profiles from pith-to-bark presented positive, neutral and negative trends. Positive trends mainly characterized light-demanding species, increasing up to 1.8 g.cm-3 per meter for Piptadeniastrum africanum, and negative trends characterized shade-bearing species, decreasing up to 1 g.cm-3 per meter for Strombosia pustulata. The linear mixed model showed the greater part of wood specific gravity variance was explained by species only (45%) followed by a redundant part between species and regeneration guilds (36%). Despite substantial variation in wood specific gravity profiles among species and regeneration guilds, we found that values from the outer wood were strongly correlated to values from the whole profile, without any significant bias. In addition, we found that wood specific gravity from the DRYAD global repository may strongly differ depending on the species (up to 40% for Dialium pachyphyllum). Main conclusion: Therefore, when estimating forest biomass in specific sites, we recommend the systematic collection of outer wood samples on dominant species. This should prevent the main errors in biomass estimations resulting from wood specific gravity and allow for the collection of new information to explore the intraspecific variation of mechanical properties of trees. [less ▲]

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See detailTémoignages de commandes publiques en architecture à Liège au 20e siècle
Charlier, Sébastien ULg; Moor, Thomas

Conference given outside the academic context (2015)

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See detailSleep-wake regulation of brain function and cognition
Vandewalle, Gilles ULg

Scientific conference (2015, November 10)

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See detailFirst New Solar Models With Opas Opacity Tables
Le Pennec, Maëlle; Turck-Chièze, Sylvaine; Salmon, Sébastien ULg et al

in Astrophysical Journal Letters (2015), 813(2), 42

Stellar seismology appears more and more as a powerful tool for a better determination of the fundamental properties of solar-type stars. However, the particular case of the Sun is still challenging. For ... [more ▼]

Stellar seismology appears more and more as a powerful tool for a better determination of the fundamental properties of solar-type stars. However, the particular case of the Sun is still challenging. For about a decade now, the helioseismic sound-speed determination has continued to disagree with the standard solar model (SSM) prediction, questioning the reliability of this model. One of the sources of uncertainty could be in the treatment of the transport of radiation from the solar core to the surface. In this Letter, we use the new OPAS opacity tables, recently available for solar modeling, to address this issue. We discuss first the peculiarities of these tables, then we quantify their impact on the solar sound-speed and density profiles using the reduced OPAS tables taken on the grids of the OPAL ones. We use the two evolution codes, Modules for Experiments in Stellar Astrophysics and Code Liégeois d'Evolution Stellaire, that led to similar conclusions in the solar radiative zone. In comparison to commonly used OPAL opacity tables, the new solar models are computed for the most recent photospheric composition with OPAS tables and present improvements to the location of the base of the convective zone and to the description of the solar radiative zone in comparison to the helioseismic observations, even if the differences in the Rosseland mean opacity do not exceed 6%. We finally carry out a comparison to a solar model computed with the OP opacity tables. [less ▲]

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See detailEvaluation of head-up and head-down displays in stereoscopic driving simulation environment
Grogna, David ULg; Sodnik, Jaka; Verly, Jacques ULg et al

Conference (2015, November 10)

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See detailConduire un projet techno-pédagogique avec trois universités francophones belges
Vincke, Grégoire ULg; Marée, Raphaël ULg; Wehenkel, Louis ULg et al

Poster (2015, November 10)

L’imagerie numérique devient omniprésente dans beaucoup de métiers, dont ceux de la médecine. Sa montée en puissance questionne l’université quant à la meilleure manière d’entraîner les étudiants à lire ... [more ▼]

L’imagerie numérique devient omniprésente dans beaucoup de métiers, dont ceux de la médecine. Sa montée en puissance questionne l’université quant à la meilleure manière d’entraîner les étudiants à lire, interpréter, comparer, contextualiser et discuter ces ressources inédites. A l’université, ces compétences s’acquièrent principalement, aux premiers stades de la formation, dans les cours d’histologie. Dans ce contexte, l’IFRES a initié un projet wallon (Appel Germaine Tillion / Convention n°1318185 http://histoweb.ifres.ulg.ac.be ) dont l’objectif est la transformation de la plate-forme logicielle wallonne Cytomine – http://cytomine.be une solution Web existante d'échange, de visualisation, d'annotation et d’analyse collaborative semi-automatique d'images numérisées – en un système d’activités pédagogiques tirant parti des initiatives partielles existant chez les partenaires et des évolutions techniques les plus récentes. Le projet HistoWeb travaille à cette transformation en s’appuyant, au plan conceptuel, sur l’exploration de la notion d’« écologie d’apprentissage ». Le projet compte parmi ses partenaires 3 universités (ULB, UNamur, Liège) et exige donc de chercher un équilibre entre des développements techno-pédagogiques susceptibles de les intéresser tous et des développements spécifiques et en prise avec les écologies d’apprentissage propres à chaque institution. Le poster présente les manières choisies par l’IFRES pour coordonner l'ensemble du projet, travaillant tantôt individuellement tantôt collectivement avec les différents partenaires. Le poster aura un mot par ailleurs sur la collaboration entre pédagogues et développeurs informatiques. En effet, l’IFRES, sur toute la durée du projet est appelé à travailler avec une équipe de recherche (Systmod) dépourvue de familiarité avec les leviers de l’enseignement et de l’apprentissage. Il évoquera aussi les collaborations espérées d’un passage en Open source. Le poster pourra apporter des éclairages aux questions : - qu’entend-on précisément par collaboration lorsqu’il s’agit de mener de la « recherche » dans un contexte académique ? Il sera ici question de cet équilibre entre convergence et différentiation. - Qui est susceptible de se développer professionnellement ? Les bénéfices tirés du projet par les uns et les autres au niveau pédagogique seront ici évoqués. [less ▲]

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See detailProduction multimédia à l’ULg : vers une typologie des usages pédagogiques et des ressources mobilisées
Martin, Pierre; Van de Poël, Jean-François ULg; Verpoorten, Dominique ULg

Conference (2015, November 10)

Ce poster introduit à une typologie de productions multimédia pédagogiques. Elle est issue d’une recherche à caractère exploratoire conduite sur plus de 1000 productions réalisées par IFRES-eCampus dans ... [more ▼]

Ce poster introduit à une typologie de productions multimédia pédagogiques. Elle est issue d’une recherche à caractère exploratoire conduite sur plus de 1000 productions réalisées par IFRES-eCampus dans le studio multimédia de l'Université de Liège. La typologie a ceci de particulier qu'elle associe chaque catégorie multimédia identifiée à une estimation des ressources nécessaire à sa production, sur le plan pédagogique, technique et de l'accompagnement. [less ▲]

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See detailWalES: an integrated database to assess ecosytem services
Maebe, Laura ULg; Pipart, Nathalie; Dendoncker, Nicolas et al

Poster (2015, November 10)

While the significance and needs of Ecosystem Services (ES) valuation is now more pregnant in decision processes, the design of operational tools remains complex because of the multiplicity and diversity ... [more ▼]

While the significance and needs of Ecosystem Services (ES) valuation is now more pregnant in decision processes, the design of operational tools remains complex because of the multiplicity and diversity of information sources, indicator types, scales of interest and the variety of managers. The most important challenges are 1) to build strong links between administrations responsible for information flows and scientists working on ES emerging definitions and valuations and 2) to re-organize these flows to link biodiversity assessment, environmental monitoring and social expectations to provide a common reference system. In Wallonia, the heads of several regional administration and academic institutions proposed to the Government to mutualize theirs skills and means to build WalES: a transdisciplinary Walloon platform on ES. Its conceptual model for ES assessment is based on a Driver-Pressure-State-Impact-Response (DPSIR) framework promoted by European Environment Agency to disentangle biodiversity and environment (state indicators) from ecosystem services (impact indicators). Ecosystem biocapacity is approached by a combination of ecological conditions (e.g. soil type and moisture, topography), main land use classes and management methods (pressures/responses indicators). ES indicators, proxy and models are declined along these three potential dimensions at different levels of precision and related to providing, benefiting, and negatively impacted stakeholders. We will present the original Walloon approach of a common and shared information system detailing data and data flows useful to assess ES, collecting relevant experiences and methods on ES valuation. The comparison of these information sources allows us to identify best practices, to combine the various data in order to improve their accuracy and to highlight missing data and methods needing further development. In this way, this operational database supports an integrated assessment of ES by measuring their diversity of components (capacity, flow and demand), values (biophysical and social) and their interactions at different scales. [less ▲]

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See detailQuel outil d'entrainement proposer aux étudiants de médecine suivant un cours de physique ?
Marique, Pierre-Xavier ULg; Hoebeke, Maryse ULg

Poster (2015, November 10)

La réforme des études de médecine mise en application dès la rentrée académique de septembre 2012 en Fédération Wallonie-Bruxelles a introduit une liste abondante de prérequis dans les cours dits de « ... [more ▼]

La réforme des études de médecine mise en application dès la rentrée académique de septembre 2012 en Fédération Wallonie-Bruxelles a introduit une liste abondante de prérequis dans les cours dits de « sciences fondamentales » (physique, chimie, biologie)et a favorisé l’évaluation sous forme de questions à choix multiples en première année de bachelier. Or, les étudiants sortant de l’enseignement secondaire maîtrisent rarement, pour de multiples raisons, l’ensemble des prérequis. Par ailleurs, ils sont très peu entraînés à ce mode d’évaluation et n’en maîtrisent donc pas les spécificités. Lors de leur arrivée à l’université, les causes d’échec des étudiants sont multiples. Parmi celles-ci, nous pouvons citer le temps d’adaptation de l’étudiant au système supérieur, la difficulté d’apprendre la nouvelle matière vue au cours (problèmes de méthode de travail, quantité de matière plus importante, laps de temps plus court pour l’assimiler, …) et, éventuellement, une mauvaise maîtrise des prérequis. Cela nous a poussé à développer un outil d’apprentissage du cours de physique. Nous avons opté pour une plate-forme en ligne afin qu’elle soit accessible à chaque instant et de n’importe quel endroit moyennant une connexion internet. L’étudiant peut notamment y travailler la nouvelle matière, ou les prérequis, via une série de tests formatifs présentés sous forme de QCM. L’étudiant peut à tout moment générer un test selon trois paramètres : la(les) matière(s) qu’ils souhaitent travailler, le temps qu’il désire y consacrer et le niveau de maîtrise qu’il souhaite atteindre à ce moment-là. La matière vue au cours a préalablement été décomposée en cinq grands thèmes. L’étudiant peut, lors de l’ouverture d’une session choisir un ou plusieurs de ces thèmes. Le nombre de questions figurant dans son test formatif dépendra de la durée qu’il aura préalablement sélectionnée (30, 60, 90 ou 120 minutes). Un barème de 10 questions par heure, identique aux conditions d’examens, est appliqué. L’étudiant pourra, en outre, choisir un niveau parmi trois échelons de difficultés. Les questions de chacune des cinq matières, issues notamment des examens des années antérieures, ont été évaluées par plusieurs membres de l’équipe pédagogique et ont été affublées d’un niveau de difficulté de 1 à 4. Vingt pools de questions ont alors été créés, soit un par niveau de difficulté de question et par matière. Une attention particulière est apportée à la rédaction des questions notamment afin de respecter les règles de conception développées par Leclercq (Leclercq, 1986) et sériant les niveaux d’abstraction des questions selon les taxonomies de Bloom (Bloom, 1956) Une fois les trois paramètres sélectionnés par l’étudiant, un test formatif est généré automatiquement. Un nombre de questions, fixé par la durée choisie par l’étudiant, est tiré aléatoirement en respectant le niveau de difficulté (du test) que l’étudiant a choisi. Le niveau « faible » de test proposera uniquement des questions de niveaux 1 et 2, le niveau « moyen », des questions de niveaux 1, 2 et 3 et le niveau « fort » des questions de niveaux 2, 3 et 4. L’étudiant pourra visualiser son état d’avancement dans la maîtrise de chacun des thèmes grâce à un rapport qu’il pourra à tout moment générer. Ce rapport détaillera également quel type (théorie, application directe de formule, problèmes, …) de questions l’étudiant a tendance à réussir ou rater. Une vue simplifiée et ludique, à l’aide de médailles à gagner sera également proposée à l’étudiant. A l’aide de cette vue simplifiée et du rapport complet, l’équipe pédagogique pourra travailler plus efficacement avec l’étudiant si cela demande un rendez-vous de remédiation. Outre cet outil, la plate-forme propose le travail des prérequis et de la nouvelle matière sous différentes forme (vidéos d’expérience à commenter, résolution guidée de problèmes, forums, questions débats, …) [less ▲]

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See detailCollaborer avec des enseignants-témoins en formation pédagogique d’adultes – Finalités, difficultés et plus-values
Leduc, Laurent ULg; Detroz, Pascal ULg; Verpoorten, Dominique ULg

Poster (2015, November 10)

En prélude à une étude empirique, ce poster problématise la décision pédagogique de faire intervenir, au cours d’une formation, des enseignants pour témoigner devant d’autres enseignants de leur pratique ... [more ▼]

En prélude à une étude empirique, ce poster problématise la décision pédagogique de faire intervenir, au cours d’une formation, des enseignants pour témoigner devant d’autres enseignants de leur pratique. Le poster recourt au QQOQCP (qui-quoi-où-quand-comment-pourquoi), une méthode qui allie simplicité et souci de complétude dans le balisage initial d’un phénomène. Sans remettre en cause la richesse des témoignages par des enseignants dans un contexte de formation, ni la satisfaction que beaucoup de participants estiment en retirer, le poster plaide pour une approche raisonnée des témoignages en soulignant certaines tensions et ambiguïtés qui peuvent marquer ces derniers. [less ▲]

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See detailRural landscape design: think local, involve locals
Boeraeve, Fanny ULg; Pipart, Nathalie; Dendoncker, Nicolas et al

Conference (2015, November 10)

The urge to involve stakeholders from the start of ecosystem service (ES) assessments is increasingly addressed in literature. This is even more the case when studying rural landscape planning for which ... [more ▼]

The urge to involve stakeholders from the start of ecosystem service (ES) assessments is increasingly addressed in literature. This is even more the case when studying rural landscape planning for which impacts on ES have proved to be highly context specific. Despite the growing amount of social ES valuations, few studies integrate them to a biophysical ES assessment. To fill in this gap, we developed a methodology where the social ES valuation directly serves the biophysical ES assessment. By combining components of the Delphi and the focus group methods, our approach allows to provide good insights on the preferred ES within the studied locality. Thanks to the deliberative phase, it also provides information on the divergences and convergences among the social values held by local stakeholders. The underpinning aim of the exercise is to reach a consent within the group. Conversely to a consensus where the decision must be unanimous, a consent seeks decisions where nobody has fundamental opposition to it. We believe that applying such approach has the potential to: - guide the biophysical ES assessment towards ES which are relevant to the study area and important in the eyes of local stakeholders; - create opportunity for collective social learning; - identify networks of influences and/or social interdependencies related to ES; - empower local stakeholders while enhancing the democratic process of decision-making. The presentation first introduces the backbone of the methodology. Two case-studies in which we applied the innovative approach will then be presented. The first case study relates to local ES assessment carried out in agroecological and conventional farms in a Western locality in Belgium. The second case-study relates to a land consolidation scheme project. Outcomes of the approach applied in both cases are put forward, and adaptation of the methodology for the distinct purposes and contexts are elucidated. [less ▲]

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See detailL’Europe et l’idée d’Europe (1945-1957)
Lanneau, Catherine ULg

Conference given outside the academic context (2015)

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