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See detailTypical versus delayed speech onset influences verbal reporting of autistic interests
Chiodo, Liliane ULiege; Majerus, Steve ULiege; Mottron, Laurent

in Molecular Autism (2017)

The distinction between autism and Asperger syndrome has been abandoned in the DSM-5. However, this clinical categorization largely overlaps with the presence or absence of a speech onset delay which is ... [more ▼]

The distinction between autism and Asperger syndrome has been abandoned in the DSM-5. However, this clinical categorization largely overlaps with the presence or absence of a speech onset delay which is associated with clinical, cognitive, and neural differences. It is unknown whether these different speech development pathways and associated cognitive differences are involved in the heterogeneity of the restricted interests that characterize autistic adults. [less ▲]

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See detailAcromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) database.
PETROSSIANS, Patrick ULiege; Daly, Adrian ULiege; Natchev, Emil et al

in Endocrine-Related Cancer (2017)

Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly ... [more ▼]

Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liege Acromegaly Survey (LAS) database, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female. Males were significantly younger at diagnosis than females (43.5 vs. 46.4 years; p<0.001). The median delay from first symptoms to diagnosis was two years longer in females (p=0.015). Ages at diagnosis and first symptoms increased significantly over time (p<0.001). Tumors were larger in males than females (p<0.001); tumor size and invasion were inversely related to patient age (p<0.001). Random GH at diagnosis correlated with nadir GH levels during OGTT (p<0.001). GH was inversely related to age in both sexes (p<0.001). Diabetes mellitus was present in 27.5%, hypertension in 28.8%, sleep apnea syndrome in 25.5% and cardiac hypertrophy in 15.5%. Serious cardiovascular outcomes like stroke, heart failure and myocardial infarction were present in <5% at diagnosis. Erythrocyte levels were increased and correlated with IGF-1 values. Thyroid nodules were frequent (34.0%); 820 patients had colonoscopy at diagnosis and 13% had polyps. Osteoporosis was present at diagnosis in 12.3% and 0.6-4.4% had experienced a fracture. This study of >3100 patients is the largest international acromegaly database and shows clinically relevant trends in the characteristics of acromegaly at diagnosis. [less ▲]

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See detailNatural patches in Posidonia oceanica meadows: the seasonal biogeochemical pore water characteristics of two edge types
Abadie, A; Borges, Alberto ULiege; Champenois, Willy ULiege et al

in Marine Biology (2017), 164:166

Seagrass meadows can be assimilated to seascape matrixes encompassing a mosaic of natural and anthropogenic patches. Natural patches within the Mediterranean Posidonia oceanica meadows show a structural ... [more ▼]

Seagrass meadows can be assimilated to seascape matrixes encompassing a mosaic of natural and anthropogenic patches. Natural patches within the Mediterranean Posidonia oceanica meadows show a structural particularity which consist in a duality of their edge types. One edge is eroded by bottom currents, while the adjacent meadow colonizes the bare sediments. This study aims to study the dynamics of these two edges through the investigation of the biogeochemistry (pH, total alkalinity, dissolved inorganic carbon, CO2, CH4, N2O, H2S, dissolved inorganic nitrogen, PO4 3−) within vegetated and unvegetated sediments. These observations are compared with the adjacent meadow to have a better understanding of the colonization processes. Our results reveal that the P. oceanica matrix shows differences from the vegetated edges of sand patches, especially with regard to nutrient availability, which is generally more important at the colonized edge (dissolved inorganic nitrogen up to 65.39 μM in June). A clear disparity also occurs between the eroded and colonized edge with both a seasonal and bathymetrical variation of leaf biomass with higher disparities at 10 m in June (colonized edge 1415 gDW m−2; eroded edge 1133 gDW m−2). Themost important contrasts during this study were assessed in June, suggesting that the warm period of the year is more suitable for sampling to highlight disparate characteristics in temperate seagrass meadows. These findings put into light the potential importance of biogeochemical processes in the dynamics of natural patch edges. We hypothesize that they may influence the structural dynamics of P. oceanica seascapes. [less ▲]

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See detailRapport de soutenance de thèse de monsieur Nicolas Forest
Swennen, Philippe ULiege

Report (2017)

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See detailEffects of User IT Capabilities and Organized Big Data Analytics on Competitive Advantage
Kamioka, Taro; Hosoya, Ryuichi; Tapanainen, Tommi ULiege

in Proceedings of the Pacific-Asian Conference on Information Systems (PACIS) (2017, July 20)

In the age of big data, it becomes important to develop capabilities for utilizing information technology (IT) in order to take advantage of the potential of data for business objectives. While users have ... [more ▼]

In the age of big data, it becomes important to develop capabilities for utilizing information technology (IT) in order to take advantage of the potential of data for business objectives. While users have received attention in many ways, we note that the capability literature has focused more on the IT supply side. We argue that user capabilities have moved to an integral position in firm competitive advantage, and call them “User IT Capabilities” (UIC). A survey was conducted to collect data from Japanese organizations, and a total valid sample of 1,170 respondents involved in big data use was extracted. The findings show the effect of UIC on the performance of big data analytics and firm competitiveness, mediated by the variable of organized big data analytics (OBDA). The direct effects are shown to be valid irrespective of company size, although the levels of UIC and OBDA are higher in larger firms. [less ▲]

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See detailQuality evaluation of peach chips and anticancer activity of pectin extracted from chips dehydrated by explosion puffing drying
Lyu, Jian ULiege

Doctoral thesis (2017)

The objectives of this research are to discriminate the overall quality level of peach and nectarine chips prepared by explosion puffing drying (EPD), determine the changes of texture and water soluble ... [more ▼]

The objectives of this research are to discriminate the overall quality level of peach and nectarine chips prepared by explosion puffing drying (EPD), determine the changes of texture and water soluble pectin (WSP) during EPD processing and study the anticancer activity of WSP on malignant mesothelioma (MM). Principle component analysis (PCA), Analytic hierarchy process (AHP), K-mean cluster and Discriminant analysis (DA) are used to distinguish the overall quality level of peach and nectarine chips and get the characteristic evaluation indicators, which of them (e. g. rehydration ratio and expansion ratio) are corresponding to texture properties of dehydrated products. Additionally, biochemical changes of the cell wall (e. g. pectin) are also related to texture changes. The investigate on the changes of texture and WSP at different stages of EPD processing in which osmotic dehydration (OD) was used as the pretreatment, show that OD with the appropriated concentration can improve the texture quality of dried products. The drying processing causes the degradation and structure modification of WSP, which can induce apoptosis in MM cells. EPD technology can be carried out as a potential pathway on modification of pectin, which may contribute to the development of a potential therapy against MM. [less ▲]

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See detailA palaeoecological model for the late Mesoproterozoic–early Neoproterozoic Atar/El Mreïti Group, Taoudeni Basin, Mauritania, northwestern Africa
Beghin, Jérémie ULiege; Guilbaud, Romain; Poulton, Simon W. et al

in Precambrian Research (2017), 299

Reconstructing the spatial distribution of early eukaryotes in palaeoenvironments through Proterozoic sedimentary basins provides important information about their palaeoecology and taphonomic conditions ... [more ▼]

Reconstructing the spatial distribution of early eukaryotes in palaeoenvironments through Proterozoic sedimentary basins provides important information about their palaeoecology and taphonomic conditions. Here, we combine the geological context and a reconstruction of palaeoenvironmental redox conditions (using iron speciation) with quantitative analysis of microfossil assemblages (eukaryotes andincertae sedis), to provide the first palaeoecological model for the Atar/El Mreïti Group of the Taoudeni Basin. Our model suggests that in the late Mesoproterozoic–early Neoproterozoic, the availability of both molecular oxygen and nutrients controlled eukaryotic diversity, higher in oxic shallow marginal marine environments, while coccoidal colonies and benthic microbial mats dominated respectively in anoxic iron-rich and euxinic waters during marine highstands or away from shore where eukaryotes are lower or absent. [less ▲]

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See detailIntraspecific variation of Zn hyperaccumulation in Arabidopsis halleri populations
Schvartzman Echenique, Maria Sol ULiege; Corso, Massimiliano; Fataftah, Nazeer ULiege et al

Conference (2017, July 19)

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See detailGenetic diversity and engineering of selected B vitamins in staple crops
Vanderschuren, Hervé ULiege

Speech/Talk (2017)

Vitamin B1, in the form thiamin diphosphate (ThDP), serves as an enzymatic cofactor for several enzymes involved in glucose metabolism, the Krebs cycle, and branched-chain amino acid biosynthesis. Vitamin ... [more ▼]

Vitamin B1, in the form thiamin diphosphate (ThDP), serves as an enzymatic cofactor for several enzymes involved in glucose metabolism, the Krebs cycle, and branched-chain amino acid biosynthesis. Vitamin B6 in its form as pyridoxal 5'-phosphate (PLP) is required as a cofactor for more than 140 enzymatic reactions in cells, primarily in amino acid, sugar and fatty acid metabolism. Mammals lack the ability to biosynthesize both vitamins B1 and B6 de novo, and plants represent one of their major sources. Symptoms of severe vitamin B1 deficiency include degeneration in the nerves and heart, a disease known as beriberi, which can be fatal. Acute vitamin B6 deficiency can lead to various chronic diseases in humans, including neurological disorders, cardiovascular disease and diabetes. Due to their importance in regions where vitamins B1 and B6 deficiencies are reported, we identified cassava and rice as good target crops for biofortification. In the present work, we performed a screening for B1 and B6 accumulation in selected varieties and landraces representative of the rice and cassava diversity. HPLC analysis allowed precise quantification of vitamin accumulation in selected genotypes contrasting for vitamin accumulation. We also report the first profiling of B1 and B6 vitamers in cassava storage roots and rice endosperm. This work is of primary importance given the reported varying degree of bioavailability for certain vitamers. Identification and expression analysis of B1 and B6 biosynthetic genes from rice and cassava was instrumental to find correlation between expression of selected biosynthetic genes and vitamin accumulation. Genetic engineering of vitamin biosynthetic pathways led to the generation of transgenic rice and cassava lines with high vitamin B6 content. Importantly, our Caco-2 cell assay demonstrated that field-grown storage roots from transgenic cassava lines accumulate high levels of bioavailable vitamin B6. Despite their key role in plant metabolism and their antioxidant activities, increased accumulation of vitamin B6 in transgenic rice and cassava lines could not be associated with improved tolerance to selected biotic or abiotic stresses under lab conditions. [less ▲]

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See detailGenetic diversity and engineering of selected B vitamins in staple crops
Vanderschuren, Hervé ULiege

Speech/Talk (2017)

Vitamin B1, in the form thiamin diphosphate (ThDP), serves as an enzymatic cofactor for several enzymes involved in glucose metabolism, the Krebs cycle, and branched-chain amino acid biosynthesis. Vitamin ... [more ▼]

Vitamin B1, in the form thiamin diphosphate (ThDP), serves as an enzymatic cofactor for several enzymes involved in glucose metabolism, the Krebs cycle, and branched-chain amino acid biosynthesis. Vitamin B6 in its form as pyridoxal 5'-phosphate (PLP) is required as a cofactor for more than 140 enzymatic reactions in cells, primarily in amino acid, sugar and fatty acid metabolism. Mammals lack the ability to biosynthesize both vitamins B1 and B6 de novo, and plants represent one of their major sources. Symptoms of severe vitamin B1 deficiency include degeneration in the nerves and heart, a disease known as beriberi, which can be fatal. Acute vitamin B6 deficiency can lead to various chronic diseases in humans, including neurological disorders, cardiovascular disease and diabetes. Due to their importance in regions where vitamins B1 and B6 deficiencies are reported, we identified cassava and rice as good target crops for biofortification. In the present work, we performed a screening for B1 and B6 accumulation in selected varieties and landraces representative of the rice and cassava diversity. HPLC analysis allowed precise quantification of vitamin accumulation in selected genotypes contrasting for vitamin accumulation. We also report the first profiling of B1 and B6 vitamers in cassava storage roots and rice endosperm. This work is of primary importance given the reported varying degree of bioavailability for certain vitamers. Identification and expression analysis of B1 and B6 biosynthetic genes from rice and cassava was instrumental to find correlation between expression of selected biosynthetic genes and vitamin accumulation. Genetic engineering of vitamin biosynthetic pathways led to the generation of transgenic rice and cassava lines with high vitamin B6 content. Importantly, our Caco-2 cell assay demonstrated that field-grown storage roots from transgenic cassava lines accumulate high levels of bioavailable vitamin B6. Despite their key role in plant metabolism and their antioxidant activities, increased accumulation of vitamin B6 in transgenic rice and cassava lines could not be associated with improved tolerance to selected biotic or abiotic stresses under lab conditions. [less ▲]

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See detailItem purification versus adjustments for multiple comparisons in DIF detection
Drabinova, Adela; Martinkova, Patricia; Magis, David ULiege

Poster (2017, July 18)

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See detailCompte-rendu de l'ouvrage de J. van der Steen: Memory Wars in the Low Countries, 1566-1700
Regibeau, Julien ULiege

in Émulations. Revue des jeunes chercheuses et chercheurs en sciences sociales (2017)

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See detailmstR: An R package to generate multistage testing designs
Magis, David ULiege; Yan, Duanli; von Davier, Alina

Conference (2017, July 18)

Multistage testing (MST; Yan, von Davier & Lewis, 2014) has become an important framework of tailored testing. Similarly to computerized adaptive testing (CAT) it proposes an optimal routing of the ... [more ▼]

Multistage testing (MST; Yan, von Davier & Lewis, 2014) has become an important framework of tailored testing. Similarly to computerized adaptive testing (CAT) it proposes an optimal routing of the administered items according to the previous test taker’s responses. However, items are not selected and administered as single units but as modules (subsets). The main goal of MST consists in selecting the optimal path of modules across the successive stages of the test. Unfortunately, if various operational testing programs are nowadays considering MST for practical administrations, there is still very limited access to accurate software that can either treat or generate MST scenarios for research purposes. In this talk we succinctly present a new package from the R software, called mstR (Magis, Yan & von Davier, 2017). Built in the same spirit of the package catR for CAT designs, it permits to generate repeated response patterns under a predefined MST scenario by providing the set of modules and related item parameters, the number of stages and the connections between modules from successive stages. Several rules for optimal module selection and ability estimation (under IRT framework or based on test scores) are also available. This talk will mostly focus on the (non-technical) description of package mstR and its main features. An example will also be described as an illustration of this framework. [less ▲]

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See detailFluencyBank: studying typical and disordered speech fluency across languages and contexts
MacWhinney, Brian; Leclercq, Anne-Lise ULiege; Zwitserlood, Rob et al

Conference (2017, July 18)

Mastering the skill to produce fluent speech is a complex task that is still poorly understood. Similarly, the threshold at which typical fluency breakdown begins to attract clinical concern is also a ... [more ▼]

Mastering the skill to produce fluent speech is a complex task that is still poorly understood. Similarly, the threshold at which typical fluency breakdown begins to attract clinical concern is also a matter of frequent disagreement. The goal of the recently funded FluencyBank project, an arm of TalkBank, is to facilitate collection and analysis of expressive speech samples across the lifespan, languages, and clinical diagnoses. Speakers will illustrate the challenges and opportunities available to the study of expressive language development skill. The first speaker (Leclercq) will examine the need for reference data across languages in order to distinguish typical developmental disfluency from stuttering, using data from French. The second speaker (Zwitserlood) will confirm and elaborate on the profile of elevated disfluency profiles in children with SLI, using Dutch data. The third speaker (Byrd) will describe the theoretical and practical challenges of discriminating typical fluency profiles from clinical stuttering in bilinguals, with emphasis on Spanish-English child speakers. The fourth speaker (Ratner) will update information linking language proficiency to stuttering onset and persistence/recovery, showing the complex interactions between speech and language formulation. Each speaker will emphasize the many intertwining skills that underlie the development of spoken language fluency and the benefits of specialized cooperative initiatives such as FluencyBank to collect data for exploration of otherwise impossible to answer hypotheses. Moderator Brian MacWhinney, Co-Investigator of FluencyBank will discuss its development, planned research projects and computational tool development, and illustrate potential applications for use by child language researchers. [less ▲]

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See detailDesigning artificial (β/α)8-barrel proteins from scratch: the Octarellin model
Martina, Cristina Elisa ULiege

Speech/Talk (2017)

De novo protein design is a growing field in protein chemistry, where artificial proteins are first designed in silico and then validated experimentally. Our group has a long tradition in the design of ... [more ▼]

De novo protein design is a growing field in protein chemistry, where artificial proteins are first designed in silico and then validated experimentally. Our group has a long tradition in the design of artificial (β/α)8-barrel proteins, known as Octarellins [1]. This fold, also known as TIM-barrel, is widespread in nature, particularly in enzymes, and represent an interesting target for therapeutic or biological applications. Here we present a novel protocol for the de novo design of TIM-barrels. Both Rosetta and Modeller modeling softwares were used to create the backbone structure of a TIM-barrel fold and to generate more than 10.000 artificial amino acid sequences. Stability was tested for the more interesting models by running molecular dynamics (MD) simulations, using GROMACS. The best models were chosen for protein production and preliminary biophysical characterization. The design of artificial proteins and the improvement of bioinformatics tools for protein modeling, structure prediction and MD simulations seem to be essential for a comprehensive knowledge of protein structure in general, as well as for an optimal use of the massive amount of data resulting from the numerous genome sequencing projects. [less ▲]

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See detailFardeau des maladies chroniques en Afrique subsaharienne : plaidoyer pour une mise en place des soins palliatifs et d’accompagnement en fin de vie en République démocratique du Congo
Lofandjola Masumbuku, Jacques ULiege

in Ethics, Medicine and Public Health (2017)

Chronic diseases (TM), to date, a burden globally, putting patients in greater need prolonged medical support. CMs are long-term (over 6 months) chronic conditions that evolve and persist over time. They ... [more ▼]

Chronic diseases (TM), to date, a burden globally, putting patients in greater need prolonged medical support. CMs are long-term (over 6 months) chronic conditions that evolve and persist over time. They require care for more than 6 months (cardiovascular, oncological diseases, chronic respiratory diseases, diabetes and HIV / AIDS), are responsible for 63% death. Relatively little reliable information about these diseases is available. Lists containing the major chronic diseases exist but they are scalable and do not always agree [less ▲]

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