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See detailComment mesurer correctement la PA chez les patients hémodialysés?
VANDERWECKENE, Pauline ULg; SAINT-REMY, Annie ULg; KRZESINSKI, Jean-Marie ULg

Poster (2016, December)

Objectifs : Le contrôle de la pression artérielle (PA) chez le patient hémodialysé (HD) est un enjeu majeur en raison des résultats controversés sur les risques cardiovasculaires qui y sont associés ... [more ▼]

Objectifs : Le contrôle de la pression artérielle (PA) chez le patient hémodialysé (HD) est un enjeu majeur en raison des résultats controversés sur les risques cardiovasculaires qui y sont associés. Cependant, la mesure de la PA dans cette population est difficile à appréhender au vu de sa grande variabilité. L’exactitude des mesures péridialytiques (enregistrées dans l’unité d’HD pendant la séance) est souvent remise en question. L’objectif de notre étude est d’établir la contribution et la concordance entre deux techniques de mesure ambulatoire pour détecter la PA non contrôlée chez ces patients HD. Il s’agit du monitoring ambulatoire interdialytique de 44h (MAPA) et de l’automesure au domicile (HBPM) pendant une durée variable de 3, 5 et 7 jours. Méthodologie : 43 patients hémodialysés chroniques (H=28, F = 15), avec une moyenne de 68,3±13 ans ont réalisé une MAPA de 44h (Spacelabs 90207), de la fin d’une séance d’HD au début de la suivante, immédiatement suivie par une automesure de 7 jours (Omron M6). Les mesures péridialytiques étaient la moyenne des PA pré-dialyse ou post-dialyse enregistrées sur 2 semaines (6 séances d’HD). L’hypertension était définie par une PA égale ou supérieure à 140/90 mmHg pour la PA pré-HD, 130/80 mmHg pour la PA post-HD, 130/80 mmHg pour la MAPA de 44 h et 135/85 mmHg pour l’HBPM. Résultats : Nous avons constaté de bonnes corrélations entre la MAPA et l’HBPM pour le diagnostic de l’hypertension chez le patient HD. Comparées aux PA péridialytiques, les 2 techniques ambulatoires ont permis d’identifier la même proportion d’hypertension masquée et d’hypertension de la blouse blanche (25%). La plus grande précision de diagnostic sur le status tensionnel est retrouvée pour les plus longues périodes d’enregistrement (44h pour la MAPA et 7 jours pour l’HBPM). Les plus courtes périodes étaient mieux tolérées par les patients mais moins précises pour détecter l’hypertension. L’automesure était plus appréciée que la MAPA de 44h. Conclusion : La MAPA et l’automesure ont permis d’identifier un quart de patients avec un phénotype particulier d’hypertension, qui n’aurait pas été classé correctement en se fiant uniquement aux mesures péridialytiques. L’automesure devrait être recommandée en première ligne chez le patient HD (au moins une semaine/mois). Cependant, la MAPA fournit des informations uniques comme la PA nocturne et pourrait être proposée, idéalement une fois par an, chez tous les patients. [less ▲]

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See detailEffectiveness of pheromone traps against Tuta absoluta
Ettaib, Refki; Belkadhi Mohamed, Sadok; Ben Belgacem, Ali et al

in Journal of Entomology and Zoology Studies (2016), 4(6)

In the Tunisian south, the heated greenhouses are an important axis of development of agriculture thanks to the big geothermal potential of this zone. Currently, this sector suffers from several ... [more ▼]

In the Tunisian south, the heated greenhouses are an important axis of development of agriculture thanks to the big geothermal potential of this zone. Currently, this sector suffers from several phytosanitary problems. In the last years, a new insect, Tuta absoluta, threaten the cultures of cultivated tomatoes in heated greenhouses. To improve control of T. absoluta, the effectiveness of pheromone traps (associated or not with a source of light) and luminous traps (associated or not with water, with limed buckets for limed covers) were compared. The results show that the traps with pheromones significantly catch more adults of T. absoluta compared to all the other types of traps (average number of trapped adults of T. absoluta = 73.4 (± 142)). The luminous traps associated with water, with limed buckets as with limed covers show, as for them, an intermediate effectiveness. In spite of this slightly less effectiveness, the luminous traps have the advantage of low costs of production as well as the advantage of simultaneously capturing males and females of T. absoluta. [less ▲]

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See detailExpanding chemistry’s horizon with continuous-flow reactors  
Monbaliu, Jean-Christophe ULg; Emmanuel, Noémie ULg; Gerardy, Romaric ULg

in Chimie Nouvelle (2016), 122

Continuous-flow micro- and mesofluidic reactors come with inherent properties that can be advantageously utilized for expanding the horizon of preparative chemistry. Accurate control over local process ... [more ▼]

Continuous-flow micro- and mesofluidic reactors come with inherent properties that can be advantageously utilized for expanding the horizon of preparative chemistry. Accurate control over local process parameters, even under extreme conditions, inherent safety, production homogeneity and seamless scale-up are amongst the most important assets of continuous-flow chemistry. Besides, flow chemistry enables the design of efficient multistep processes with significantly reduced footprints. In this note, we discuss some of the most fascinating aspects of continuous-flow micro- and mesofluidic reactors in the specific context of preparative organic chemistry. [less ▲]

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See detailNutritional Composition and Rearing Potential of the Meadow Grasshopper (Chorthippus parallelus Zetterstedt)
Paul, Aman ULg; Frederich, Michel ULg; Uyttenbroeck, Roel ULg et al

in Journal of Asia-Pacific Entomology (2016), 19(4), 1111-1116

Insects, particularly those belonging to the family Acrididae (grasshoppers), are commonly consumed as human food in many parts of the world. Grasshoppers of the species Chorthippus parallelus are ... [more ▼]

Insects, particularly those belonging to the family Acrididae (grasshoppers), are commonly consumed as human food in many parts of the world. Grasshoppers of the species Chorthippus parallelus are abundantly found throughout Europe. However, these insects were not consumed by Europeans till now, but could possibly be used as human food, which is why we investigated their chemical composition. We found that they contain high level of proteins (69%), with an excellent amino acid profile and protein digestibility (97%). Furthermore, specimens of C. parallelus have an interesting fatty acids profile and minerals composition. Preliminary toxicity assessment indicates that these insects do not exhibit toxicity towards neutrophil cells (white blood cells). These data suggest that C. parallelus could be considered for human consumption. Rearing trials done during the study show that commercial rearing could be developed to produce sufficient biomass for sustaining human consumption. [less ▲]

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See detailAssessing edge-effects in Posidonia oceanica seagrass meadows: A multidisciplinary approach
Lapeyra, Jon; Abadie, Arnaud; Lejeune, Pierre et al

Conference (2016, December)

Structural boundaries in ecosystems play an important role both in the context of seascape architecture, ecological processes and biodiversity. The Mediterranean Seagrass Posidonia oceanica (L.) Delile is ... [more ▼]

Structural boundaries in ecosystems play an important role both in the context of seascape architecture, ecological processes and biodiversity. The Mediterranean Seagrass Posidonia oceanica (L.) Delile is considered an ecosystem engineer species, forming habitats of great ecological value and providing many ecosystem services. This study aims to (1) determine whether there are differences between seagrass-sand corridors edges and the adjacent continuous meadow, and (2) investigate whether anthropogenic pressures can cause disturbances in the measured parameters along the edges and the meadow. We have developed a multidisciplinary approach combining plant physiology, faunal canopy community studies and seagrass structural parameters characterization. We performed in situ chlorophyll fluorescence measurements using a Pulse Amplitude Modulated (Diving-PAM) fluorometry in order to assess the photosynthetic rate of the shoots. Vagile macrofauna of the leaf stratum was sampled by a hand-towed net, and the major taxonomic groups were sorted, counted, and identified. Meadow’s biometric measurements and the epiphytic biomass were also determined. Regarding edge-meadow matrix, results have shown highest differences on matrix structural parameters such as shoot density and shoot type proportions. Shoot density was found to decrease in edges considerably. We found c.a to 60 % plagiotropic shoots on edges while in continuous meadow orthotropics were predominant (up to 90 %). Howerver vagile-fauna population densities and diversity did not differ significantly among stations studied, neither by sites. Photosynthetic rate and leaf surface values also did not show changes between edges and continuous meadow. However, results did show that plagiotropic shoots had higher photosynthetic rate than orthotropics, and also that epiphyte abundance sorted out to be much higher (up to 54 %) on edges. [less ▲]

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See detailLa vignette thérapeutique de l'étudiant. Le choix entre un inhibiteur de la DPP-4 et un inhibiteur des SGLT2 pour traiter le diabète de type 2 (2016)
SCHEEN, André ULg; PAQUOT, Nicolas ULg

in Revue Médicale de Liège (2016), 71(12), 579-585

Summary : Two new classes of oral antidiabetic agents play an increasing role in the management of type 2 diabetes, dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) and sodiumglucose cotransporters ... [more ▼]

Summary : Two new classes of oral antidiabetic agents play an increasing role in the management of type 2 diabetes, dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) and sodiumglucose cotransporters type 2 (SGLT2) inhibitors (gliflozins). After failure of a monotherapy with metformin (first pharmacological choice in type 2 diabetes), both may offer an alternative to the add-on of a sulphonylurea, especially in patients at risk of hypoglycaemia. However, the choice between a DPP-4 inhibitor and a SGLT2 inhibitor is not easy and should be oriented based upon the individual patient characteristics. The arguments in favour of one or another pharmacological class are discussed, considering a clinical case of a patient with coronary heart disease and type 2 diabetes not well controlled with metformin. [less ▲]

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See detailWorkshop: Comparative methods in evolutionary biology
Frederich, Bruno ULg; Santini, Francesco

Conference (2016, December)

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See detailLes valeurs européennes, dernier rempart à la survie de l'UE
Habran, Maxime ULg

Article for general public (2016)

Le 23 juin 2016, l’Union européenne (UE) s’est un peu plus enfoncée dans la crise. Les britanniques se sont prononcés en faveur d’une sortie du Royaume-Uni de l’Union européenne à 51,9% contre 48,1%. Quoi ... [more ▼]

Le 23 juin 2016, l’Union européenne (UE) s’est un peu plus enfoncée dans la crise. Les britanniques se sont prononcés en faveur d’une sortie du Royaume-Uni de l’Union européenne à 51,9% contre 48,1%. Quoi qu’on en dise, il s’agit d’une décision inédite pour l’Europe. Un électrochoc de plus dans l’histoire de la construction européenne. Cet énième écueil marque sans doute la fin d’une union sans cesse plus étroite entre les peuples de l’Europe. [less ▲]

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See detailSoluble forms of CD46 are detected in Bos taurus plasma and neutralize BVDV, the bovine pestivirus
Alzamel, Nidal ULg; Bayrou, Calixte ULg; Decreux, Annabelle et al

in Comparative Immunology, Microbiology and Infectious Diseases (2016), 49

The pestivirus bovine viral diarrhea virus (BVDV) is known to bind to the CD46 molecule, which subsequently promotes entry of the virus. Mapping of the BVD-virion-binding site has shown that two peptides ... [more ▼]

The pestivirus bovine viral diarrhea virus (BVDV) is known to bind to the CD46 molecule, which subsequently promotes entry of the virus. Mapping of the BVD-virion-binding site has shown that two peptides, 66EQIV69 and 82GQVLAL87, located on antiparallel beta sheets in the most distal complement control protein module (CCP1), provide the attachment platform. In the present study, we reveal new CD46-encoding transcripts that are predicted to encode CCP1-containing soluble forms. Further, we show that the serum of most adult cattle contains soluble CD46 (sCD46) and that a recombinant soluble isoform neutralizes BVDV infectivity in an in vitro assay. We have then established an ELISA for determination of plasma sCD46 in a large cohort of animals. Overall, serum sCD46 amounts to 8 ± 18 ng/mL (mean ± SD, n = 440), with a IC [95-105] ranging from 6,4 to 9,8 ng/mL and extreme values between 0 and 178 ng/mL. We found that sCD46 is not detectable in fetal and neonatal sera and that its plasma concentration increases progressively up to adulthood. We also detected high- and low-sCD46 performers and show that this phenotype does not depend of environment. As modern rearing techniques make it possible to disseminate genetically-determined phenotypes very quickly in a population, a large-scale study examining whether high-sCD46 animals provide epidemiological protection against BVDV infection and transmission should be undertaken. [less ▲]

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See detailOrganic and mechanical properties of Cervidae antlers: a review
Picavet, Pierre; Balligand, Marc ULg

in Veterinary Research Communications (2016), 40(3), 141-147

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See detailImportin-8 mutations could cause Jeavons Syndrome, CAE and JME by altering early neuroblast migration
Nganou, Gerry ULg; Tanaka, Miyabi; Coumans, Bernard ULg et al

Poster (2016, December)

Jeavons syndrome (JS) is an uncommon form of juvenile epilepsy. In some family affected by JS, the gene of importin-8 (IPO8) a member of karyopherin superfamily of proteins, has been found mutated ... [more ▼]

Jeavons syndrome (JS) is an uncommon form of juvenile epilepsy. In some family affected by JS, the gene of importin-8 (IPO8) a member of karyopherin superfamily of proteins, has been found mutated. Karyopherin are known to regulate nucleo-cytoplasmic transport of many proteins. IPO8, a member of the β-karyopherin sub-family, is reported to control the transport Ago-2, c-Jun and Smad-4 for example, three proteins important for brain development. Here, we show that IPO8 is well expressed in mouse brain at embryonic stage. Moreover inhibition of IPO8 mRNA by shRNA in-utéro-electroporation (IUE), impairs early neuroblast migration as weel as IUE overexpression of mutated form of human IPO8. So, abnormal brain development due to IPO8 mutations could be at the origin of Jeavons Syndrome, Chilhood abscence evolving (CAE) and/or juvenile myoclonic epilepsy (JME). [less ▲]

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See detailDu tell à l'histoire : stratégie et techniques de fouille au Proche-Orient
Mas, Juliette ULg

Scientific conference (2016, December)

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See detailNouveaux paradigmes et métaphores du traitement du mélanome cutané
PIERARD, Gérald ULg; NIZET, Jean-Luc ULg; HUMBERT, P.

in Revue Médicale de Liège (2016), 71(12), 562-566

In recent years, new drugs have been designed for treating advanced cutaneous malignant melanoma, in particular the metastases. They afford modest benefits despite the fact they are commonly heralded as ... [more ▼]

In recent years, new drugs have been designed for treating advanced cutaneous malignant melanoma, in particular the metastases. They afford modest benefits despite the fact they are commonly heralded as breakthroughs in the lay press and by some medical opinion leaders. Unfortunately, the use of inflated descriptors of the drug efficacy leads to misunderstandings among the clinicians in charge of patients. Currently, vemurafenib, ipilimumab, pembrolizumab and nivolumab have demonstrated their relative activity in the control of advanced malignant melanoma. The results expected from surrogate markers of efficacy are magnified and idealized regarding the expectations from many patients. The recent therapeutic advance improves the median overall survival for a few months. Some combined treatments could possibly boost the current beneficial effects. [less ▲]

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See detailFirst Hubble Space Telescope Movies of Jupiter’s Ultraviolet Aurora During the NASA Juno Prime Mission
Grodent, Denis ULg; Gladstone, G. Randall; Clarke, John T. et al

Poster (2016, December)

The primary goal of this HST campaign is to complement Juno-UVS (Ultraviolet Spectrograph) observations. This complementarity is four-fold as HST observes Jupiter’s aurora when: 1) Juno-UVS is turned off ... [more ▼]

The primary goal of this HST campaign is to complement Juno-UVS (Ultraviolet Spectrograph) observations. This complementarity is four-fold as HST observes Jupiter’s aurora when: 1) Juno-UVS is turned off, that is about 98% of Juno’s 14-day orbit, and Juno’s in situ instruments are in operation. 2) Juno-UVS is operating, but observes the opposite hemisphere of Jupiter. 3) UVS is on in the same hemisphere, but too close to Jupiter to have a global, contextual, view of the aurora and/or UVS is affected by the noise induced by Jupiter’s radiation belts. 4) Juno is too far from Jupiter to get a detailed view of the aurora. In addition, HST will observe the auroral and airglow emissions of the Galilean moons Io, Ganymede and Europa, when UVS is measuring their auroral footprints in Jupiter’s ionosphere. During this campaign, HST is obtaining 45-min STIS time-tag images -movies- of both hemispheres of Jupiter and STIS/COS spectra of Jupiter's moons. These observations are taking place during 4 sequences of Juno's orbit (Figure: typical orbit in magnetic coordinates): 1) Perijove segment: a 6-hour sequence bracketing the time of Juno's closest approach of Jupiter. 2) Crossing segments: few hours periods during which Juno is crossing the magnetic equator of Jupiter and in situ instruments are observing the plasma sheet particles. 3) Perijove +/- 1 Jovian rotation (or more), to provide a context for the auroral activity before and after perijove. 4) Apojove segment: a 12-hour period bracketing the time when Juno is farthest from Jupiter and Juno-UVS is continuously monitoring the global auroral UV power of Jupiter. During Juno orbit PJ5, between 28 Nov. and 07 Dec. 2016, HST obtains 9 STIS movies: 3 movies of the northern aurora near perijove, 1 movie (north) one Jovian rotation before and 2 movies (south- north) one and two Jovian rotations after perijove, 2 movies (north) during two close CS crossings, and 1 movie near apojove. These movies will be commented during this presentation. [less ▲]

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See detailProperties of Jupiter’s auroral acceleration region inferred with HST-STIS spectral images
Ray, Licia C.; Arridge, Christopher S.; Gustin, Jacques et al

Poster (2016, December)

Jupiter’s dynamic auroral region is the signature of magnetosphere-ionosphere coupling. Precipitating auroral electrons are part of a current system which transports angular momentum from the planetary ... [more ▼]

Jupiter’s dynamic auroral region is the signature of magnetosphere-ionosphere coupling. Precipitating auroral electrons are part of a current system which transports angular momentum from the planetary atmosphere to sub-corotating magnetospheric plasma. The magnitude of the currents and hence precipitating energy flux, are sensitive to the characteristics of the high-latitude magnetosphere, in particular the location of the auroral acceleration region (AAR) and the density and temperature of the high-latitude electron population. We use HST STIS observations of Jupiter’s aurora (Gustin et al. [2016]) to infer the location of the AAR and the properties of the precipitating auroral electrons. To do this, we determine the energy of the precipitating electrons and incident energy flux for the two distinct regions within the main aurora and within flare regions. The resulting relationships between energy flux and electron precipitation energy for the main auroral emission are then compared to the theoretical relationship derived by Lundin & Sandahl [1978], in order to derive the location of the AAR and the temperatures and densities of the electrons at the top of the AAR prior to acceleration. We find that that each emission region is best reproduced using a multiple auroral acceleration regions with different properties, rather than a single auroral acceleration region with a varying potential drop strength. [less ▲]

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See detailContinuous Monitoring of Jupiter's Aurora and Io Plasma Torus with the Hisaki Satellite during Joint Observing Campaign with Juno
Kimura, Tomoki; Yamazaki, Atsushi; Murakami, Go et al

Poster (2016, December)

The Hisaki satellite is the first space telescope that is dedicated to observations of our solar system bodies. Hisaki has been continuously monitoring the atmosphere and magnetosphere of the solar system ... [more ▼]

The Hisaki satellite is the first space telescope that is dedicated to observations of our solar system bodies. Hisaki has been continuously monitoring the atmosphere and magnetosphere of the solar system bodies with the extreme ultraviolet (EUV) spectroscope EXCEED since the launch in September 2013. Dynamics on timescales from 10s minutes to a few years were discovered in the atmosphere and magnetosphere by the continuous monitoring. Large joint observing campaigns for Jupiter by the Juno spacecraft in coordination with Hisaki, the Hubble Space Telescope (HST), and other facilities started in mid-2016. Before Jupiter Orbit Insertion, Juno made the in-situ solar wind measurements while Hisaki was simultaneously monitoring Jupiter's aurora and Io plasma torus. On Day of Year 142, Hisaki discovered that the EUV auroral emission power rapidly increased by a factor of ~3 but returned to a nominal level within one planetary rotation. The transient aurora was followed by brightening of the torus sulfur and oxygen ions that is proxy of the hot electron populations in the torus. At the same time, the relatively weak solar wind shock signatures were found in the JUNO/JEDI energetic particle data (Clark et al.). The transient variability is compared to the morphology observed by HST (Nichols et al.). Hisaki is going to monitor Jupiter in collaboration with the large observing program of HST (Grodent et al.) that will make ~150 exposures from this November. [less ▲]

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See detailComment mieux valoriser les fourrages riches en azote ?
Herremans, Sophie ULg

Article for general public (2016)

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See detailThe Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme
Ahn, Minkoo; Hagan; Bernardo-Gancedo et al

in Biophysical Journal (2016)

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See detailSurfactant instillation in spontaneously breathing preterm infants: a systematic review and meta-analysis.
RIGO, Vincent ULg; LEFEBVRE, Caroline ULg; BROUX, Isabelle ULg

in European Journal of Pediatrics (2016), 175(12), 1933-1942

Less invasive surfactant therapies (LIST) use surfactant instillation through a thin tracheal catheter in spontaneously breathing infants. This review and meta-analysis investigates respiratory outcomes ... [more ▼]

Less invasive surfactant therapies (LIST) use surfactant instillation through a thin tracheal catheter in spontaneously breathing infants. This review and meta-analysis investigates respiratory outcomes for preterm infants with respiratory distress syndrome treated with LIST rather than administration of surfactant through an endotracheal tube. Randomised controlled trial (RCT) full texts provided outcome data for bronchopulmonary dysplasia (BPD), death or BPD, early CPAP failure, invasive ventilation requirements and usual neonatal morbidities. Relative risks (RR) from pooled data, with subgroup analyses, were obtained from a Mantel-Haenszel analysis using a random effect model. Six RCTs evaluated LIST: 4 vs InSurE and 1 each vs delayed or immediate intubation for surfactant. LIST resulted in decreased risks of BPD (RR = 0.71 [0.52-0.99]; NNT = 21), death or BPD (RR = 0.74 [0.58-0.94]; NNT = 15) and early CPAP failure or invasive ventilation requirements (RR = 0.67 [0.53-0.84]; NNT = 8 and RR = 0.69 [0.53-0.88]; NNT = 6). Compared to InSurE, LIST decreased the risks of BPD or death (RR = 0.63 [0.44-0.92]; NNT = 11) and of early CPAP failure (RR = 0.71 [0.53-0.96]; NNT = 11). Common neonatal morbidities were not different. CONCLUSIONS: Respiratory management with LIST decreases the risks of BPD and BPD or death, and the need for invasive ventilation. This strategy appears safe, but long-term follow-up is lacking. WHAT IS KNOWN: • Initial management of preterm infants with CPAP decreases the risk of death or BPD, but many still require surfactant or invasive ventilation. • Surfactant can be instilled through a tracheal thin catheter while the infant breathes on CPAP, but improvement in BPD is inconsistent between studies. What is New: • Less invasive surfactant therapy (LIST) strategies decrease the risks of BPD, of death or BPD, and of CPAP failure compared to strategies where surfactant is administered through an endotracheal tube. • LIST strategies decrease the risks of the composite outcome of BPD or death and of early CPAP failure when compared to "intubation-surfactant-extubation" approaches. [less ▲]

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See detailAccompagnement de la mise en oeuvre des recommandations de la recherche sur les formations initiales : vers la mise en place d’un nouveau système - Rapport d'activités
Pirard, Florence ULg; Dethier, Anne ULg; Housen, Marie ULg

Report (2016)

Ce rapport rend compte des activités menées dans le suivi de la recherche sur les formations initiales dans le champ de l'accueil de l'enfance (Pirard al. 2015). Il garde trace des diverses communications ... [more ▼]

Ce rapport rend compte des activités menées dans le suivi de la recherche sur les formations initiales dans le champ de l'accueil de l'enfance (Pirard al. 2015). Il garde trace des diverses communications réalisées durant l'année 2016 et propose en conclusion des pistes de réflexion et d'action à poursuivre en vue d'une nécessaire réforme. [less ▲]

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