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See detailVehicle routing problems with loading constraints: State-of-the-art and future directions
Pollaris, Hanne; Braekers, Kris; Caris, An et al

in OR Spectrum (2015), 37(Issue 2), 297-330

Distributors are faced with loading constraints in their route planning, e.g.,multi-dimensional packing constraints, unloading sequence constraints, stability constraints and axle weight limits. Ignoring ... [more ▼]

Distributors are faced with loading constraints in their route planning, e.g.,multi-dimensional packing constraints, unloading sequence constraints, stability constraints and axle weight limits. Ignoring these constraints impairs planning and induces last-minute changes resulting in additional costs. Developing vehicle routing models incorporating loading constraints is critical to more efficient route planning. The last couple of years has seen a huge increase of contributions to this field of research with almost 60 % of these being published after 2009. Our contribution is twofold. First, we overview the recent developments in the literature on all vehicle types in which loading constraints play a key role (trucks, airplanes, ships, and automated guided vehicles), using a state-of-the-art classification scheme to identify the loading constraints considered in each article. Second, we identify research gaps and opportunities for future research. [less ▲]

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See detailA Systematic Review of Cost-Effectiveness Analyses of Drugs for Postmenopausal Osteoporosis.
Hiligsmann, Mickaël ULg; Evers, Silvia M.; Ben Sedrine, Wafa et al

in PharmacoEconomics (2015), 33(3), 205-224

BACKGROUND: Given the limited availability of healthcare resources and the recent introduction of new anti-osteoporosis drugs, the interest in the cost effectiveness of drugs in postmenopausal ... [more ▼]

BACKGROUND: Given the limited availability of healthcare resources and the recent introduction of new anti-osteoporosis drugs, the interest in the cost effectiveness of drugs in postmenopausal osteoporosis remains and even increases. OBJECTIVE: This study aims to identify all recent economic evaluations on drugs for postmenopausal osteoporosis, to critically appraise the reporting quality, and to summarize the results. METHODS: A literature search using Medline, the National Health Service Economic Evaluation database and the Cost-Effectiveness Analysis Registry was undertaken to identify original articles published between January 1, 2008 and December 31, 2013. Studies that assessed cost effectiveness of drugs in postmenopausal osteoporosis were included. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement was used to assess the quality of reporting of these articles. RESULTS: Of 1,794 articles identified, 39 studies fulfilled the inclusion criteria. They were conducted in 14 different countries and nine active interventions were assessed. When compared with no treatment, active osteoporotic drugs were generally cost effective in postmenopausal women aged over 60-65 years with low bone mass, especially those with prior vertebral fractures. Key drivers of cost effectiveness included individual fracture risk, medication adherence, selected comparators and country-specific analyses. Quality of reporting varied between studies with an average score of 17.9 out of 24 (range 7-21.5). CONCLUSION: This review found a substantial number of published cost-effectiveness analyses of drugs in osteoporosis in the last 6 years. Results and critical appraisal of these articles can help decision makers when prioritizing health interventions and can inform the development of future economic evaluations. [less ▲]

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See detailLe Journal d’Antoine Galland (1646-1715) : la période parisienne. Volume III (1712-1713)
Bauden, Frédéric ULg; Waller, Richard; Veymiers, Richard ULg et al

Book published by Peeters (2015)

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See detailÉvaluation technico-économique de la production de plants de teck (Tectona grandis L.f.) dans les pépinières villageoises au Sud-Bénin
Séhouéto, Caroline K. P.; Aoudji, Augustin K. N.; Avocèvou-Ayisso, Carolle et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19(1), 32-41

The present study deals with the production of the seedlings of teak (Tectona grandis L.f.), a species used in forest plantations in southern Benin. The aim of the study was to evaluate the techniques and ... [more ▼]

The present study deals with the production of the seedlings of teak (Tectona grandis L.f.), a species used in forest plantations in southern Benin. The aim of the study was to evaluate the techniques and the profitability of teak seedling production in the community nurseries of southern Benin. [less ▲]

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See detailLe Journal d’Antoine Galland (1646-1715) : la période parisienne. Volume IV (1714-1715)
Bauden, Frédéric ULg; Waller, Richard; Veymiers, Richard ULg et al

Book published by Peeters (2015)

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See detailA Lower Tournaisian (Hastarian) silicified brachiopod-coral fauna from South Belgium
Denayer, Julien ULg; Mottequin, Bernard; Poty, Edouard

Conference (2015)

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See detailNon-myeloablative allogeneic hematopoietic cell transplantation following fludarabine plus 2 Gy TBI or ATG plus 8 Gy TLI: a phase II randomized study from the Belgian Hematological Society
Baron, Frédéric ULg; Zachée, Pierre; Maertens, Johan et al

in Journal of Hematology & Oncology (2015), 8(4), 10118613045-014-0098-9

Background: Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). Methods: Here, we report the ... [more ▼]

Background: Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). Methods: Here, we report the results of a phase II multicenter randomized study comparing non-myeloablative allo-HCT from HLA-identical siblings (n = 54) or from 10/10 HLA-matched unrelated donors (n = 40) with either fludarabine plus 2 Gy total body irradiation (Flu-TBI arm; n = 49) or 8 Gy TLI + anti-thymocyte globulin (TLI-ATG arm; n = 45) conditioning. Results: The 180-day cumulative incidences of grade II-IV acute GVHD (primary endpoint) were 12.2% versus 8.9% in Flu-TBI and TLI-ATG patients, respectively (P = 0.5). Two-year cumulative incidences of moderate/severe chronic GVHD were 40.8% versus 17.8% in Flu-TBI and TLI-ATG patients, respectively (P = 0.017). Five Flu-TBI patients and 10 TLI-ATG patients received pre-emptive DLI for low donor chimerism levels, while 1 Flu-TBI patient and 5 TLI-ATG patients (including 2 patients given prior pre-emptive DLIs) received a second HCT for poor graft function, graft rejection, or disease progression. Four-year cumulative incidences of relapse/progression were 22% and 50% in Flu-TBI and TLI-ATG patients, respectively (P = 0.017). Four-year cumulative incidences of nonrelapse mortality were 24% and 13% in Flu-TBI and TLI-ATG patients, respectively (P = 0.5). Finally, 4-year overall (OS) and progression-free survivals (PFS) were 53% and 54%, respectively, in the Flu-TBI arm, versus 54% (P = 0.9) and 37% (P = 0.12), respectively, in the TLI-ATG arm. Conclusions: In comparison to patients included in the Flu-TBI arm, patients included in the TLI-ATG arm had lower incidence of chronic GVHD, higher incidence of relapse and similar OS. [less ▲]

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See detailLe témoignage comme structure d’expression pour le théâtre-action, étude de cas : Royal Boch, la dernière défaïence
Brahy, Rachel ULg; Ieven, Emilie

in Quillet, Françoise (Ed.) La scène mondiale aujourd'hui. Des formes en mouvement (2015)

Depuis quelques années, nous constatons la présence significative des témoins et témoignages au sein du théâtre et ce, quelle que soit la forme que celui-ci prend. Le théâtre-action, théâtre participatif ... [more ▼]

Depuis quelques années, nous constatons la présence significative des témoins et témoignages au sein du théâtre et ce, quelle que soit la forme que celui-ci prend. Le théâtre-action, théâtre participatif et engagé, a recours depuis son origine à d’authentiques témoins dans certaines de ses productions. A la fois sujets et comédiens des événements qu’ils ont vécus, ces témoins possèdent un statut particulier, paradoxal du fait qu’ils entremêlent des logiques a priori contradictoires : la logique de vécu et la logique fictionnelle. La mise en tension de ces deux logiques apparait comme un nœud fécond suscitant de nombreuses interrogations. Confrontant la théorie à un cas pratique (l’étude de la pièce Royal Boch, la dernière défaïence), le présent article propose de mettre en lumière la dimension politique du témoin au sein d’une pièce de théâtre-action. Après avoir dressé un bref panorama informatif de l’histoire du théâtre-action, nous présenterons – dans un premier temps - notre étude de cas, Royal Boch, la dernière défaïence. Dans un deuxième temps, la réflexion se concentrera sur la structure du témoignage et sa mise en pratique au sein de la pièce Royal Boch. Dans un troisième temps, l’article problématisera, sous l’angle de l’authenticité, la relation entre témoignages/témoins et la dimension fictionnelle inhérente à toute pièce théâtrale. Sur base des différents éléments analysés, la réflexion mettra en exergue l’efficacité politique de la figure du témoin dans le théâtre-action. [less ▲]

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See detailSoil redistribution and weathering controlling the fate of geochemical and physical carbon stabilization mechanisms in soils of an eroding landscape
Doetterl, Sebastien; Six, Johan; Bodé, Samuel et al

in Biogeosciences (2015)

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See detailNylon flocked swab severely reduces Hexagon Obti sensibility
Frippiat, Christophe; De Roy, Gilbert; Fontaine, Louis-Marie et al

in Forensic Science International (2015), 247(0), 126-129

Abstract Hexagon Obti immunological blood test and flocked swab are widely used in forensic laboratories. Nevertheless, up to now, no compatibility tests have been published between sampling with the ... [more ▼]

Abstract Hexagon Obti immunological blood test and flocked swab are widely used in forensic laboratories. Nevertheless, up to now, no compatibility tests have been published between sampling with the ethylene oxide treated flocked swab and the Hexagon Obti blood detection strip. In this study, we investigated this compatibility. Our work shows that sampling with ethylene oxide treated flocked swab reduces by a factor of at least 100 the detection threshold of blood using the Hexagon Obti immunological test. [less ▲]

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See detailNotions de pharmacologie
Kaux, Jean-François ULg

Learning material (2015)

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See detailMorphological details in bloodstain particles
De Wael, Kris; Lepot, Laurent ULg

in Forensic Science International (2015), 246(0), 50-54

Abstract During the commission of crimes blood can be transferred to the clothing of the offender or on other crime related objects. Bloodstain particles are sub-millimetre sized flakes that are lost from ... [more ▼]

Abstract During the commission of crimes blood can be transferred to the clothing of the offender or on other crime related objects. Bloodstain particles are sub-millimetre sized flakes that are lost from dried bloodstains. The nature of these red particles is easily confirmed using spectroscopic methods. In casework, bloodstain particles showing highly detailed morphological features were observed. These provided a rationale for a series of experiments described in this work. It was found that the “largest” particles are shed from blood deposited on polyester and polyamide woven fabrics. No particles are lost from the stains made on absorbent fabrics and from those made on knitted fabrics. The morphological features observed in bloodstain particles can provide important information on the substrates from which they were lost. [less ▲]

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See detailA linear accelerator for levitated micro-objects
Sari, Ibrahim; Kraft, Michael ULg

in Sensors and Actuators. A, Physical (2015)

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See detailPituitary MRI characteristics in 297 acromegaly patients based on T2-weighted sequences.
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Daly, Adrian ULg et al

in Endocrine-related cancer (2015)

Context: Responses of GH-secreting adenomas to multimodal management of acromegaly varies widely between patients. Understanding the behavioral patterns of GH-secreting adenomas by identifying predictive ... [more ▼]

Context: Responses of GH-secreting adenomas to multimodal management of acromegaly varies widely between patients. Understanding the behavioral patterns of GH-secreting adenomas by identifying predictive factors of their evolution is a research priority. Objective: To clarify the relationship between adenoma T2-weighted signal on diagnostic MRI in acromegaly and clinical and biological features at diagnosis. Design: International, multicenter, retrospective analysis. Setting: 10 endocrine tertiary referral centers. Patients: 297 acromegalic recently diagnosed patients with available diagnostic MRI evaluations were included in the study. Main outcome measure: Clinical, biochemical characteristics and MRI signal findings. Results: T2-hypointense adenomas represented 52.9% of the series, were smaller than their T2-hyper- and isointense counterparts (p<0.0001), were associated with higher IGF1 levels (p=0.0001), invaded the cavernous sinus less frequently (p=0.0002) and rarely caused optic chiasm compression (p<0.0001). Acromegalic men tended to be younger at diagnosis than women (p=0.067) and presented higher IGF1 values (p=0.01). Although in total, adenomas had a predominantly inferior extension in 45.8% of cases, in men this was more frequent (p<0.0001), whereas in women optic chiasm compression of macroadenomas occurred more often (p=0.0067). Most adenomas (45.1%) measured between 11-20mm in maximal diameter and bigger adenomas were diagnosed at younger ages (p=0.0001). Conclusions: T2-weighted signal differentiates GH-secreting adenomas into subgroups with particular behaviors. This raises the question of whether T2-weighted signal could represent a factor in the classification of acromegalic patients in future studies. [less ▲]

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See detailLa fin du Paléolithique moyen dans le Nord de l’Europe : la question des origines du Lincombien-Ranisien-Jerzmanowicien
Flas, Damien ULg

in Depaepe, Pascal; Goval, Emilie; Koehler, Héloïse (Eds.) et al Les plaines du Nord-Ouest : carrefour de l’Europe au Paléolithique moyen ? (2015)

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See detailWhen Children’s Knowledge of Memory Improves Children’s Performance in Memory
Geurten, Marie ULg; Catale, Corinne ULg; Meulemans, Thierry ULg

in Applied Cognitive Psychology (2015), 29

One of the strongest hypotheses in the field of metacognition research involves the positive effect of metamemory on memory performance. However, due to the lack of appropriate instruments to appraise ... [more ▼]

One of the strongest hypotheses in the field of metacognition research involves the positive effect of metamemory on memory performance. However, due to the lack of appropriate instruments to appraise knowledge of memory, few studies have examined this effect among children. This study was conducted to create and validate an instrument to assess children’s metamemory knowledge and link this knowledge with their memory performance and strategy use. A sample of 166 children was given a new three-factor metamemory interview, and its psychometric properties were investigated. Regression analyses were carried out to investigate the link between metamemory and memory performance in a subgroup of 128 children from the validation study. Results confirmed the scale’s good psychometric properties and revealed its ability to predict children’s memory performance. However, none of the scale’s factors could predict children’s use of memory strategies. Implications for the study of children’s metamemory development are discussed. [less ▲]

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See detailLos portafolios : Hacia una evaluacion mas integrada y coherente con el concepto de desempeno complejo
Poumay, Marianne ULg; Maillart, Christelle ULg

in Leclercq, Dieudonné; Cabrera, Alvaro (Eds.) Innovaciones en Dispositivos de Evaluacion de los Aprendizajes en la ensenanza Superior. (2015)

Le présent chapitre prend résolument le parti du témoignage et construit sur l’expérience des auteures. Il choisit quelques référents théoriques, qu’il illustre ensuite par deux expériences ciblées, l’une ... [more ▼]

Le présent chapitre prend résolument le parti du témoignage et construit sur l’expérience des auteures. Il choisit quelques référents théoriques, qu’il illustre ensuite par deux expériences ciblées, l’une chez les étudiants en logopédie/orthophonie et l’autre chez les étudiants en pédagogie de l’enseignement supérieur, deux programmes de l’Université de Liège. Il conclut sur quelques réflexions et perspectives. [less ▲]

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See detailThe age of river-transported carbon: A global perspective
Marwick, Trent R.; Tamooh, Fredrick; Teodoru, Cristian R. et al

in Global Biogeochemical Cycles (2015), 29(2), 122--137

The role played by river networks in regional and global carbon (C) budgets is receiving increasing attention. Despite the potential of radiocarbon measurements (Δ14C) to elucidate sources and cycling of ... [more ▼]

The role played by river networks in regional and global carbon (C) budgets is receiving increasing attention. Despite the potential of radiocarbon measurements (Δ14C) to elucidate sources and cycling of different riverine C pools, there remain large regions for which no data are available and no comprehensive attempts to synthesize the available information and examine global patterns in the 14C content of different riverine C pools. Here we present new 14C data on particulate and dissolved organic C (POC and DOC) from six river basins in tropical and subtropical Africa and compiled >1400 literature Δ14C data and ancillary parameters from rivers globally. Our analysis reveals a consistent pattern whereby POC is progressively older in systems carrying higher sediment loads, coinciding with a lower organic carbon content. At the global scale, this pattern leads to a proposed global median Δ14C signature of −203‰, corresponding to an age of ~1800 years B.P. For DOC exported to the coastal zone, we predict a modern (decadal) age (Δ14C = +22 to +46‰), and paired data sets confirm that riverine DOC is generally more recent in origin than POC—in contrast to the situation in ocean environments. Weathering regimes complicate the interpretation of 14C ages of dissolved inorganic carbon, but the available data favor the hypothesis that in most cases, more recent organic C is preferentially mineralized. [less ▲]

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