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See detailA new ent-clerodane diterpenoid from Crassocephalum bauchiense Huch. (Asteraceae).
Tchinda, Alembert T.; Mouokeu, Simplice R.; Ngono, Rosalie A. N. et al

in Natural product research (2015)

A phytochemical investigation of the whole plant of Crassocephalum bauchiense Huch. resulted in the isolation of a new clerodane diterpenoid, ent-2beta,18,19-trihydroxycleroda-3,13-dien-16,15-olide (1 ... [more ▼]

A phytochemical investigation of the whole plant of Crassocephalum bauchiense Huch. resulted in the isolation of a new clerodane diterpenoid, ent-2beta,18,19-trihydroxycleroda-3,13-dien-16,15-olide (1), together with two known flavonoids 3',5-dihydroxy-4',5',6,7,8-pentamethoxyflavone (2) and 4',5-dihydroxy-3',5',6,7,8-pentamethoxyflavone (3). The compounds were tested against the chloroquine-sensitive 3D7 strain of Plasmodium falciparum. Compound 2 showed weak activity (IC50 = 10.1 g/mL) whilst compounds 1 and 3 were inactive. The structures of the compounds were elucidated by using detailed spectral analyses, especially 1H and 13C NMR, 1H-1H COSY, NOESY, HMBC and HR-ESI-MS. [less ▲]

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See detailIncentive salience attribution under reward uncertainty: A Pavlovian model
Anselme, Patrick ULg

in Behavioural Processes (2015), 111(1), 6-18

There is a vast literature on the behavioural effects of partial reinforcement in Pavlovian conditioning. Compared with animals receiving continuous reinforcement, partially rewarded animals typically ... [more ▼]

There is a vast literature on the behavioural effects of partial reinforcement in Pavlovian conditioning. Compared with animals receiving continuous reinforcement, partially rewarded animals typically show (a) a slower development of the conditioned response (CR) early in training and (b) a higher asymptotic level of the CR later in training. This phenomenon is known as the partial reinforcement acquisition effect (PRAE). Learning models of Pavlovian conditioning fail to account for it. In accordance with the incentive salience hypothesis, it is here argued that incentive motivation (or ‘wanting’) plays a more direct role in controlling behaviour than does learning, and reward uncertainty is shown to have an excitatory effect on incentive motivation. The psychological origin of that effect is discussed and a computational model integrating this new interpretation is developed. Many features of CRs under partial reinforcement emerge from this model. [less ▲]

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See detailPour une pensée politique des émotions : Kluge et Ferenczi dans Die Macht der Gefühle
Cormann, Grégory ULg; Hamers, Jérémy ULg

in Caeymaex, Florence; Goddard, Jean-Christophe (Eds.) Critiques en crise. Enjeux et significations de la critique aujourd'hui (2015)

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See detailTowards a New Edition of the 'Répertoire métrique de la poésie des troubadours'
Valenti, Gianluca ULg

in Neophilologus (2015), 99(1), 15-27

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See detailInscriptiones Lesbi, Nesi, Tenedi
Famerie, Etienne ULg

Report (2015)

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See detailApprendre les langues durant un séjour Erasmus: la compétence plurilingue entre normes et pratiques
Meunier, Deborah ULg

in Contributions au développement de perspectives plurilingues en éducation et formation (2015)

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See detailNeuromodulation in cluster headache.
Fontaine, Denys; Vandersteen, Clair; MAGIS, Delphine ULg et al

in Advances and technical standards in neurosurgery (2015), 42

Medically refractory chronic cluster headache (CH) is a severely disabling headache condition for which several surgical procedures have been proposed as a prophylactic treatment. None of them have been ... [more ▼]

Medically refractory chronic cluster headache (CH) is a severely disabling headache condition for which several surgical procedures have been proposed as a prophylactic treatment. None of them have been evaluated in controlled conditions, only open studies and case series being available. Destructive procedures (radiofrequency lesioning, radiosurgery, section) and microvascular decompression of the trigeminal nerve or the sphenopalatine ganglion (SPG) have induced short-term improvement which did not maintain on long term in most of the patients. They carried a high risk of complications, including severe sensory loss and neuropathic pain, and consequently should not be proposed in first intention.Deep brain stimulation (DBS), targeting the presumed CH generator in the retro-hypothalamic region or fibers connecting it, decreased the attack frequency >50 in 60 % of the 52 patients reported. Complications were infrequent: gaze disturbances, autonomic disturbances, and intracranial hemorrhage (2).Occipital nerve stimulation (ONS) was efficient (decrease of attack frequency >50 %) in about 70 % of the 60 patients reported, with a low risk of complications (essentially hardware related). Considering their respective risks, ONS should be proposed first and DBS only in case of ONS failure.New on-demand chronically implanted SPG stimulation seemed to be efficient to abort CH attacks in a pilot controlled trial, but its long-term safety needs to be further studied. [less ▲]

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See detailLa magie et la sorcellerie des visages comme socle anthropologique de la philosophie sartrienne
Englebert, Jérôme ULg

in Etudes Sartriennes (2015), 17

L’« émotion » est la possibilité d’une « anthropologie de la relation ». Énoncer une telle proposition nécessite de définir les deux blocs qu’elle relie. Nous réaliserons cette entreprise en recourant à ... [more ▼]

L’« émotion » est la possibilité d’une « anthropologie de la relation ». Énoncer une telle proposition nécessite de définir les deux blocs qu’elle relie. Nous réaliserons cette entreprise en recourant à un troisième axe, intermédiaire : celui du visage ou, plutôt, des visages. La thèse de ce court essai tient à considérer que la phénoménologie sartrienne a déjà réalisé ce travail de fond qui requiert, pour le rendre explicite, articulation simple et ordonnancement. [less ▲]

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See detailInfluence of mouse strain on ovarian tissue recovery after engraftment with angiogenic factor.
Fransolet, Maïté ULg; Henry, Laurie ULg; Labied, Soraya et al

in Journal of Ovarian Research (2015), 8(1), 14

BACKGROUND: For women facing gonadotoxic treatment, cryopreservation of ovarian tissue with subsequent retransplantation during remission is a promising technique for fertility preservation. However ... [more ▼]

BACKGROUND: For women facing gonadotoxic treatment, cryopreservation of ovarian tissue with subsequent retransplantation during remission is a promising technique for fertility preservation. However, follicle loss within grafted ovarian tissue can be caused by ischemia and progressive revascularization. Several xenograft models using different immunodeficient rodent lines are suitable for studying ovarian tissue survival and follicular viability after frozen-thawed ovarian cortex transplantation. SCID mice, which are deficient for functional B and T cells, are the most commonly used mice for ovarian xenograft studies. However, due to incomplete immunosuppression, NOD-SCID mice displaying low NK cell function and an absence of circulating complement might be more appropriate. The present study aims to define the most appropriate immunodeficient mouse strain for ovarian tissue xenotransplantation by comparing ovarian graft recovery in SCID and NOD-SCID mice following engraftment in the presence of isoform 111 of vascular endothelial growth factor. METHODS: Sheep ovarian cortex fragments were embedded in a collagen matrix, with or without VEGF111, before being stitched onto the ovaries of SCID and NOD-SCID mice. Transplants were recovered after 3 days to study early revascularization or after 3 weeks to evaluate follicle preservation and tissue fibrosis through histological analyses. RESULTS: At day 3, vessels were largely reorganized in the ovarian grafts of both mouse strains. After 3 weeks, the cortical tissue was clearly identifiable in SCID mice but not in NOD-SCID mice. Upon VEGF111 treatment, vascularization was significantly improved 3 days after transplantation in SCID mice. This increase in vessel density was correlated with better follicular preservation in SCID mice 3 weeks after transplantation. Fibrosis was not decreased by VEGF treatment in either mouse strain. CONCLUSIONS: Tissue architecture and follicular morphology were better preserved in ovarian tissues grafted in SCID mice in comparison with NOD-SCID mice. Moreover, tissue revascularization was improved in SCID mice by VEGF111 graft treatment. Thus, we consider SCID mice to be the best murine model for studying ovarian tissue xenografts. [less ▲]

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See detailRecognition of Personally Familiar Faces and Functional Connectivity in Alzheimer’s Disease
Kurth, Sophie ULg; Moyse, Evelyne ULg; Bahri, Mohamed Ali ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2015), 67

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See detailApplication of random eigenvalue analysis to assess bridge flutter probability
Canor, Thomas; Caracoglia, Luca; Denoël, Vincent ULg

in Journal of Wind Engineering and Industrial Aerodynamics (2015), 140(0), 79--86

Abstract This study examines the well-known issue of evaluating the flutter probability for a long-span bridge, necessary for assessing structural integrity and reliability. The motivation stems from the ... [more ▼]

Abstract This study examines the well-known issue of evaluating the flutter probability for a long-span bridge, necessary for assessing structural integrity and reliability. The motivation stems from the need for critically reviewing and investigating a number of existing numerical approaches (e.g., random perturbation analysis, collocation methods, Galerkin approach) for the modeling and the solution of stochastic dynamic problems, by adapting them to the specific problem. The study proposes a generalized formulation for stochastic bridge flutter in terms of random eigenvalue analysis. A 1200 m suspension bridge model is used in the numerical simulations to compare the various methods and to provide indications on advantages and limitations of each method. Moreover, the link between the proposed formulation and existing studies on the propagation of uncertainty in aeroelastic systems, for example associated with measurement errors in wind tunnel, is examined. [less ▲]

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See detailCatalogue of the types and illustrated specimens recovered from the ‘black marble’ of Denée, a marine conservation-Lagerstätte from the Mississippian of southern Belgium
Mottequin, Bernard ULg; Poty, Edouard; Prestianni, Cyrille

in Geologica Belgica (2015)

The Viséan ‘black marble’ of Denée is one of the best preserved Mississippian fossil assemblages. This Lagerstätte is famous for the exceptional preservation of several groups of macro-organisms (fishes ... [more ▼]

The Viséan ‘black marble’ of Denée is one of the best preserved Mississippian fossil assemblages. This Lagerstätte is famous for the exceptional preservation of several groups of macro-organisms (fishes, echinoids, graptolites). However, only a part of the fauna has received attention from specialists and most of the phyla may benefit from a modern revision based on new investigative techniques such as 3D imagery and CT-scanning. Almost all the specimens illustrated in the literature have been traced and we present here a comprehensive catalogue of this material. Representatives of several minor groups are photographically illustrated for the first time as well as five emblematic specimens of the styracopterid genus Benedenius (Pisces). For purposes of nomenclatural formality, the lectotypes of Benedenius deneensis Traquair (in de Koninck, 1878), B. soreili Fraipont, 1890, Oligoporus soreili Fraipont, 1904, Taeniaster? fournieri Fraipont, 1904, and Scaphiocrinus longicaudatus Fraipont, 1904 are here selected. [less ▲]

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See detailHypothalamic Expression Of Oestrogen Receptor Alpha And Androgen Receptor Is Sex, Age And Region Dependent In Mice.
Brock, Olivier; Mees, Christelle De; Bakker, Julie ULg

in Journal of neuroendocrinology (2015)

Sex steroid hormones act on developing neural circuits regulating the hypothalamic-pituitary-gonadal axis and are involved in hormone-sensitive behaviours. These hormones act mainly via nuclear receptors ... [more ▼]

Sex steroid hormones act on developing neural circuits regulating the hypothalamic-pituitary-gonadal axis and are involved in hormone-sensitive behaviours. These hormones act mainly via nuclear receptors, i.e. oestrogen receptor-alpha (ERalpha) and androgen receptor (AR). By using immunohistochemistry, we analysed the expression level of ERalpha and AR throughout perinatal life [at embryonic (E) day 19 and postnatal (P) days 5-15-25] and in adulthood in several hypothalamic nuclei controlling reproduction in both wild-type (WT) and aromatase knockout (ArKO) (which cannot convert testosterone into oestradiol) mice to determine whether there are sex differences in hypothalamic ERalpha and AR expression and if so, whether these are established by oestradiol action. As early as E19, ERalpha immunoreactivity (-ir) was observed at same expression levels in both sexes in the anteroventral periventricular nucleus (AVPv), the medial preoptic area (MPOA), the bed nucleus of the stria terminalis (BnST), the ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) and the arcuate nucleus (ARC). Sex differences (female > male) in ERalpha-ir were only observed during the prepubertal period in the BnST (P5 to P25) and the MPOA (P15), but also in adulthood in these two brain regions. Sex differences in AR-ir (male > female) were observed at P5 in the AVPv and ARC, and at P25 in the MPOA and ARC as well as in adulthood in all hypothalamic regions analysed. In adulthood, gonadectomy and hormonal treatment (oestradiol or dihydrotestosterone) also strongly modulated ERalpha-ir and AR, respectively. Taken together, sex differences in ERalpha-ir and AR-ir were observed in all hypothalamic regions analysed, but most likely do not reflect oestradiol actions since ArKO mice of both sexes showed very similar expression levels as WT mice throughout perinatal development. This article is protected by copyright. All rights reserved. [less ▲]

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See detailGIS-Based Landslide Susceptibility Mapping in the Great Lakes Region of Africa, Case Study of Bujumbura Burundi
Nibigira, L.; Draidia, Salah ULg; Havenith, Hans-Balder ULg

in Engineering Geology for Society and Territory-Volume 2 (2015)

Abstract: Landslides in Central Africa represent a constant threat to the population. The present work took its motivation from the increasing number of recorded incidents in recent times. It is focused ... [more ▼]

Abstract: Landslides in Central Africa represent a constant threat to the population. The present work took its motivation from the increasing number of recorded incidents in recent times. It is focused on the analysis of mass movements in a regional context. Remote sensing based on the use of satellite images (Pleiades images of 2011) and aerial photographs (1957, 1958 and 1981) allowed us to identify instabilities at different scales. The study of these mass movements and the characterization of the processes governing ... [less ▲]

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See detailHazard and Risk Related to Earthquake-Triggered Landslides
Havenith, Hans-Balder ULg; Fan, X.; Torgoev, A.

in Engineering Geology for Society and Territory-Volume 2 (2015)

Abstract This paper first analyses how important earthquake-induced landslide hazards are compared to other geohazards at world-wide scale. Further, we will outline where these hazards may have the ... [more ▼]

Abstract This paper first analyses how important earthquake-induced landslide hazards are compared to other geohazards at world-wide scale. Further, we will outline where these hazards may have the strongest impacts—at regional and local scale. In this regard, we consider the short-and long-term effects of geological, tectonic, climatic and morphological conditions. Hazard and risk related to these processes will also be analysed on the basis of a series of case histories: eg, the 1920 Haiyuan earthquake-landslide disaster in China. A ... [less ▲]

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See detailLandslide Susceptibility Mapping with Data Mining Methods—a Case Study from Maily-Say, Kyrgyzstan
Braun, A.; Fernandez-Steeger, T.; Havenith, Hans-Balder ULg et al

in Engineering Geology for Society and Territory-Volume 2 (2015)

Abstract: Multiple factors, such as geology, high mountain topography, seismic activity, climatic conditions and mining activities cause significant landslide hazard in the region around Maily-Say ... [more ▼]

Abstract: Multiple factors, such as geology, high mountain topography, seismic activity, climatic conditions and mining activities cause significant landslide hazard in the region around Maily-Say, Kyrgyzstan. To assess the landslide susceptibility a database containing landslide information and geological, morphological and hydrological parameters associated with landslide occurrence was established and analyzed with different data mining algorithms. The most promising results were achieved with an Artificial Neural ... [less ▲]

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See detailValidation and test cases for a free surface PSH model
Goffin, Louis ULg; Erpicum, Sébastien ULg; Dewals, Benjamin ULg et al

in Advances in hydroinformatics - Simhydro 2014 (2015)

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See detailThe EChO science case
Tinetti, Giovanna; Drossart, Pierre; Eccleston, Paul et al

in ArXiv e-prints (2015), 1502

The discovery of almost 2000 exoplanets has revealed an unexpectedly diverse planet population. Observations to date have shown that our Solar System is certainly not representative of the general ... [more ▼]

The discovery of almost 2000 exoplanets has revealed an unexpectedly diverse planet population. Observations to date have shown that our Solar System is certainly not representative of the general population of planets in our Milky Way. The key science questions that urgently need addressing are therefore: What are exoplanets made of? Why are planets as they are? What causes the exceptional diversity observed as compared to the Solar System? EChO (Exoplanet Characterisation Observatory) has been designed as a dedicated survey mission for transit and eclipse spectroscopy capable of observing a large and diverse planet sample within its four-year mission lifetime. EChO can target the atmospheres of super-Earths, Neptune-like, and Jupiter-like planets, in the very hot to temperate zones (planet temperatures of 300K-3000K) of F to M-type host stars. Over the next ten years, several new ground- and space-based transit surveys will come on-line (e.g. NGTS, CHEOPS, TESS, PLATO), which will specifically focus on finding bright, nearby systems. The current rapid rate of discovery would allow the target list to be further optimised in the years prior to EChO's launch and enable the atmospheric characterisation of hundreds of planets. Placing the satellite at L2 provides a cold and stable thermal environment, as well as a large field of regard to allow efficient time-critical observation of targets randomly distributed over the sky. A 1m class telescope is sufficiently large to achieve the necessary spectro-photometric precision. The spectral coverage (0.5-11 micron, goal 16 micron) and SNR to be achieved by EChO, thanks to its high stability and dedicated design, would enable a very accurate measurement of the atmospheric composition and structure of hundreds of exoplanets. [less ▲]

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