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See detailDoes the achievement of an intermediate glycemic target reduce organ failure and mortality? A post-hoc analysis of the Glucontrol Trial
Penning, Sophie ULg; Chase, J. Geoffrey; Preiser, Jean-Charles et al

in Journal of Critical Care (2014)

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See detailInhibition of PDH Kinase as a new therapeutic target for Age-related Macular Degeneration (AMD)
Arslan, Deniz ULg; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

Poster (2014, June)

Metabolomics is one of the most recent technologies in the world of Omics sciences. It aims at studying metabolome, which is composed of small molecular weight organic molecules (called metabolites) of a ... [more ▼]

Metabolomics is one of the most recent technologies in the world of Omics sciences. It aims at studying metabolome, which is composed of small molecular weight organic molecules (called metabolites) of a cell, an organism or a biological system. This approach gives rise to a growing number of applications in many areas, such as biomarkers discovery, clinical studies, drug efficacy and toxicity evaluation, diagnostic tools, quality control. One of the most interesting features of metabolomics is its capability to extract biochemical information reflecting biological events and then to be a powerful tool in the knowledge of the aetiology of some pathologies. Indeed, it is clear that every disease could alter more or less drastically the metabolic profile of the patients. Then a metabolomics approach could highlight the biochemical pathways affected and could allow the identification of new putative therapeutic strategies or targets that could be useful in a new drug discovery strategy. As proteomics, metabolomics approach represents a new and powerful tool for Medicinal Chemistry. Age-related Macular Degeneration (AMD) is a leading cause of vision loss in the western world among people aged 50 or older. 90% of all vision loss due to AMD results from the exudative form, which is characterized by choroidal neovascularization (CNV). Age-related changes that induce pathologic CNV are incompletely understood. A successful application of anti-VEGF approaches in the clinic is obviously a turning point in AMD treatment. Nevertheless, despite such important advances, critical issues remain to be addressed. To better understand the aetiology of this pathology, we used and improved a murine model of laser-induced choroidal neovascularization and applied a 1H NMR metabolomics study. This approach leads to the emergence of different putative biomarkers and to the validation of the CNV model for an experimental study of AMD. Among these “biomarkers”, lactate appears to be clearly involved in the development of AMD. The modulation of their plasma concentration by treatment of the animals with synthetic compounds and more specifically Pyruvate DesHydrogenase Kinase inhibitors (PDHK) significantly decrease the impact of laser induced CNV. Starting from these results, the development of new PDHK inhibitors could open the way to innovative treatment opportunities in AMD disease. [less ▲]

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See detailSocial Security and Economic Integration
Artige, Lionel ULg; Dedry, Antoine ULg; Pestieau, Pierre ULg

in Economics Letters (2014), 123(June), 318-322

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See detailThe Call for project proposals « Let’s live my village »: between free interpretations and compulsory readings regarding innovation and convivial village ambiance in Wallonia.
Schmitz, Serge ULg

in Les campagnes: espaces d'innovation dans un monde urbain (2014, June)

The paper scrutinizes 186 rural development projects selected on the short list of the first and second “Lets’ live my village!” calls. It examines trends concerning rural community life and the identity ... [more ▼]

The paper scrutinizes 186 rural development projects selected on the short list of the first and second “Lets’ live my village!” calls. It examines trends concerning rural community life and the identity of the leaders/brokers. It pays attention to the way that associations define rurality. Question 14 of the application form « Does your association act in rural areas? Explain” is the main source of information for content analysis and contingency tables [less ▲]

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See detailPhysical controls on the storage of methane in landfast sea ice
Zhou, Jiayun ULg; Tison, J.-L.; Carnat, G. et al

in The Cryosphere (2014), 8(3), 1019-1029

We report on methane (CH4) dynamics in landfast sea ice, brine and under-ice seawater at Barrow in 2009. The CH4 concentrations in under-ice water ranged between 25.9 and 116.4 nmol L-1sw, indicating a ... [more ▼]

We report on methane (CH4) dynamics in landfast sea ice, brine and under-ice seawater at Barrow in 2009. The CH4 concentrations in under-ice water ranged between 25.9 and 116.4 nmol L-1sw, indicating a supersaturation of 700 to 3100 % relative to the atmosphere. In comparison, the CH4 concentrations in sea ice, ranged between 3.4 and 17.2 nmol L-1ice, and the deduced CH4 concentrations in brine, between 13.2 and 677.7 nmol L-1brine. We investigated on the processes explaining the difference in CH4 concentrations between sea ice, brine and the under-ice water, and suggest that biological controls on the storage of CH4 in ice was minor in comparison to the physical controls. Two physical processes regulated the storage of CH4 in our landfast ice samples: bubble formation within the ice and sea ice permeability. Gas bubble formation from solubility changes had favoured the accumulation of CH4 in the ice at the beginning of ice growth. CH4 retention in sea ice was then twice as efficient as that of salt; this also explains the overall higher CH4 concentrations in brine than in the under-ice water. As sea ice thickened, gas bubble formation became less efficient, CH4 was then mainly trapped in the dissolved state. The increase of sea ice permeability during ice melt marked the end of CH4 storage. [less ▲]

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See detailCHARACTERIZATION OF PROTEINURIA IN DOGUE DE BORDEAUX DOGS USING ELECTROPHORESIS AND URINARY BIOMARKERS
Lavoué, Rachel; Smets, P.; Trumel, Cathy et al

in Proceedings of the 2014 ACVIM Forum (2014, June)

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See detailL’effet d’un dispositif public d’accompagnement et de formation belge sur les trajectoires professionnelles des demandeurs d’emploi
Gérard, Julie ULg

Conference (2014, June)

: Suite aux récents bouleversements économiques et sociaux touchant les pays de l’Union Européenne, de nombreux partenariats entre services publics d’emploi et agences d’emploi privées se sont développés ... [more ▼]

: Suite aux récents bouleversements économiques et sociaux touchant les pays de l’Union Européenne, de nombreux partenariats entre services publics d’emploi et agences d’emploi privées se sont développés et complexifiés, suivant une logique de gestion mixte du marché de l’emploi. Cette communication porte sur l’étude d’un partenariat public-privé entre un service public régional belge et un organisme de formation. À partir des apports conceptuels et théoriques de la sociologie de l’action publique et de la littérature propre aux agences d’emploi privées et aux partenariats public-privé, nous analyserons la capacité d’un dispositif public à assurer la remise à l’emploi de son public-cible. Pour ce faire, nous étudierons son rôle et ses effets sur les trajectoires professionnelles des demandeurs d’emploi y recourant. [less ▲]

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See detailL’effet des dispositifs d’intermédiation sur les trajectoires professionnelles des travailleurs. Le cas d’un bureau de recrutement, recherche et sélection de personnel.
Gérard, Julie ULg

Conference (2014, June)

Au cours de ces dernières années, le souci d’allier flexibilité et sécurité au travail a conduit à l’essor considérable des métiers de l’intermédiation (Orianne et Maroy, 2008). En particulier dans le ... [more ▼]

Au cours de ces dernières années, le souci d’allier flexibilité et sécurité au travail a conduit à l’essor considérable des métiers de l’intermédiation (Orianne et Maroy, 2008). En particulier dans le domaine de l’accompagnement et du développement de carrière, divers dispositifs privés d’aide et de suivi ont vu le jour afin de contribuer à l’amélioration des conditions de travail et d’assister les travailleurs dans leurs transitions professionnelles. Par leur action, ces nouveaux dispositifs n’hésitent pas à complexifier les temporalités sociales en créant de nouvelles opportunités d’emploi et en redéfinissant les rythmes de carrière. À l’aide d’une étude de cas dans le secteur du recrutement belge, nous analyserons la capacité d’un processus de mise en emploi à remplir de tels objectifs dans un contexte de gestion mixte du marché du travail. Approchée d’une manière qualitative (entretiens semi-directifs et observations), nous étudierons l’apport de cette agence de placement au travers d’un cadre théorique qui intègre les concepts de dispositif (Foucault, 1977 ; Peeters et Charlier, 1999 ; Raffnsoe, 2008) et de réseaux sociaux (Grossetti 2005, 2008 et 2011). Nous montrerons qu’un plus de régir l’offre et la demande de travail, ce dispositif d’intermédiation, par son système de cooptation et son accompagnement de carrière, assure la fluidification du marché et sécurise la dynamique des transitions professionnelles. [less ▲]

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See detailLaTeX, un peu, beaucoup (4. Les "équations" et leurs styles)
Dupont, Pascal ULg

in Losanges (2014)

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See detailGCxGC-HRTOFMS a Powerful Tool in Separation Science
Focant, Jean-François ULg

Scientific conference (2014, June)

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See detailUsing intensive multiyear fish-pass monitoring to analyse seasonal upstream movement patterns of patrimonial holobiotic potomadromous fish species in a medium size river
Benitez, Jean-Philippe ULg; Nzau Matondo, Billy ULg; Dierckx, Arnaud ULg et al

in Proceedings of the 10th International Conference on Ecohydraulics (2014, June)

Belgian rivers are fragmented by numerous obstacles which considerably limit the free access of fish to functional habitats. Fish-passes are major tools used to increase stream continuity and improve ... [more ▼]

Belgian rivers are fragmented by numerous obstacles which considerably limit the free access of fish to functional habitats. Fish-passes are major tools used to increase stream continuity and improve connectivity in the upstream direction. Using two modern multispecies fish-passes, this study aims to investigate multiyear abundance of holobiotic potamodromous fish and their seasonal movement patterns in relation with environmental factors. The fish passes were monitored continuously during 5 and 7 years and are located in two Belgian streams: the (19.3m³.s-1) and the Berwinne (1.9m³.s-1). Results revealed the presence of 20 different fish species, 14 species in the Berwinne and 19 species in the occurrence, salmonids and cyprinids species were predominant. A great interspecific and intraspecific variability in capture periodicity and in terms of stimulation by combination of factor environmental was observed. This study highlights the complexity and the omnipresence of holobiotic potamodromous fish movements at different life stages, in medium size river and brings new information on fish passes efficiency and use by these poorly known species. [less ▲]

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See detailLe “Pacte budgétaire” européen, quelle influence sur les finances publiques belges ?
Uhoda, Maxime ULg

in Pyramides : Revue du Laboratoire d’Etudes et de Recherches en Administration Publique (2014), 25(25 - 2014/1), 87-122

La contribution se propose d’étudier les nouvelles obligations qui découlent du « pacte budgétaire » contenu dans le « Traité sur la stabilité, la coordination et la gouvernance au sein de l'union ... [more ▼]

La contribution se propose d’étudier les nouvelles obligations qui découlent du « pacte budgétaire » contenu dans le « Traité sur la stabilité, la coordination et la gouvernance au sein de l'union économique et monétaire ». Il s’agit d’un traité intergouvernemental signé par vingt-cinq États membres de l’Union européenne (à l’exclusion du Royaume-Uni et de la République Tchèque) dont le contenu est appelé à être intégré dans le cadre juridique de l’Union avant le 1er janvier 2018. Dans le contexte d’une double dynamique que connaissent actuellement les finances publiques des États membres de la zone euro – d’un côté, la construction de l’Union économique et monétaire européenne et de l’autre côté, dans certains pays, des phénomènes de décentralisation fiscale – le resserrement de la discipline budgétaire européenne semble traduire une tendance vers l’émergence de nouveaux principes constitutionnels de type financier. En Belgique, les modalités concrètes de transposition de ces nouvelles obligations – à savoir, l’incorporation en droit belge d’une règle d’équilibre budgétaire définie en termes structurels, l’instauration d’un « mécanisme de correction interne » et la mise en place d’une autorité de contrôle budgétaire indépendante, passent par la signature d’un accord de coopération et de nouvelles missions confiées à la section « Besoins de financement des pouvoirs publics » du Conseil supérieur des finances. [less ▲]

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See detailEstimated Subglottic Pressure Evaluation According to Vocal Pathology. Study on 418 Patients
Morsomme, Dominique ULg; Chareix, Hélène; FINCK, Camille ULg et al

Conference (2014, May 31)

Estimated subglottic pressure (ESGP) is part of the aerodynamic measurements included in the vocal profile. It is an indication of vocal effort and can guide the therapist in his clinical approach. We aim ... [more ▼]

Estimated subglottic pressure (ESGP) is part of the aerodynamic measurements included in the vocal profile. It is an indication of vocal effort and can guide the therapist in his clinical approach. We aim to examine the clinical interest of the ESGP by observing its values according to voice pathology, age, gender and sound pressure level. We also examine the relationships between PSGE, DSI and VHI. Method:The study includes 418 patients (M:118/W:300). Each patient’s file consists of VLS, acoustic, aerodynamic and perceptual measures. The ESGP was collected through the Phonatory Aerodynamic System Model 6600 (KayPentax). Patients produced 3 sequences of / ipipi / at low (IL), conversational (IC) and high (IH) intensity. Patients were grouped according to the ENT’s diagnosis. Results: Patients without vocal lesions (MTD) had a significantly lower ESGP compared to patients with nodules, polyps, inflammation, edema (IL, IC), cysts (IC) or scar (IC). Patients with vocal fold atrophy had a lower ESGP than those suffering from nodules and polyps at conversational and high intensity, but were not differentiated at low intensity. Amongst patients without lesions (MTD), a positive correlation appeared between ESGP and intensity; which was not the case for patients with lesions. At high intensity, men had a significantly higher ESGP than women. At low intensity, we noted a positive correlation between the VHI scores and ESGP levels. At low and conversational intensity, we observed a negative correlation between DSI and ESGP scores. Conclusion: This study highlights the importance of considering ESGP in the vocal profile. As expected, patients with vocal pathology produce high ESGP. However, the correlations between intensity and ESGP vary depending on the patient's pathology. In addition, ESPG values allow the clinician to distinguish MTD and healthy patients and thus could help the therapist in his clinical approach. [less ▲]

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See detailFalsos positivos de C5-carnitina elevada en cribado neonatal: A que son debidos?
Yahyaoui, Raquel; Rueda; Dayaldasani, Anita et al

in Medicina Clinica (2014)

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See detailWind Tunnel Testing of a VTOL MAV Propeller in Tilted Operating Mode
Theys, Bart; Dimitriadis, Grigorios ULg; Andrianne, Thomas ULg et al

in Proceedings of the 2014 International Conference on Unmanned Aircraft Systems (ICUAS 2014) (2014, May 30)

This paper presents experimental results of the full 3-axis force vector and 3-axis moment vector acting on a propeller, commonly used for a Vertical Take Off and Landing Micro Aerial Vehicle (VTOL MAV ... [more ▼]

This paper presents experimental results of the full 3-axis force vector and 3-axis moment vector acting on a propeller, commonly used for a Vertical Take Off and Landing Micro Aerial Vehicle (VTOL MAV). Measurements were carried out in a wind tunnel using a high resolution 6-axis force/moment sensor embedded in a customized test rig at several wind speeds, propeller rotational speeds and angles of the propeller shaft with respect to the air stream. Results show strong moments acting on the propeller in forward flight and unstable conditions in descending flight. Power calculations reveal a decrease in power consumption during slow forward flight and how motor efficiency can be maximized. [less ▲]

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See detailBoard attributes and conditional conservatism: Evidence from French firms
Boussaid, Nabila ULg; Sougné, Danielle ULg; Hamza, Taher

Conference (2014, May 30)

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