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See detailProjet Appui à la mise en oeuvre du FLEGT dans les Forêts Communautaires – AFFC-Rapport final
Kerkhofs, Benoit; Julve, Cécila; Federspiel, Michele et al

Report (2013)

Le projet « Appui à la mise en oeuvre du FLEGT dans les Forêts Communautaires » (AFFC) vise à promouvoir la mise en oeuvre du FLEGT au Cameroun et s’est fixé comme objectif spécifique de renforcer les ... [more ▼]

Le projet « Appui à la mise en oeuvre du FLEGT dans les Forêts Communautaires » (AFFC) vise à promouvoir la mise en oeuvre du FLEGT au Cameroun et s’est fixé comme objectif spécifique de renforcer les capacités des acteurs locaux pour améliorer leur responsabilisation effective dans ce processus. Parmi les bénéficiaires de l’action figurent 13 Forêts Communautaires (FC) de Mindourou, Lomié et Messamena ainsi que le regroupement de forêts communautaires REFOCOD, tous situés dans la Région de l’Est, Département du Haut-Nyong. La figure 1 reprend la carte de localisation des FC partenaires. Le projet AFFC se décline en 3 volets principaux. Le premier concerne la sensibilisation des acteurs locaux au programme FLEGT et aux accords de partenariat volontaires. Un deuxième volet se focalise sur le renforcement des capacités de contrôle de la société civile et de l'administration grâce, notamment, à des formations sur des thématiques en rapport avec l'APV-FLEGT et identifiées par la grille d'analyse de l'autonomie, un des outils d'évaluation interne du projet. Enfin, le troisième axe consiste en un diagnostic confrontant les réalités du terrain aux exigences de l'APV. Le premier trimestre a été, en majeure partie, consacré au lancement du projet du point de vue organisationnel, à l'étude d'état des lieux [KERKHOFS, 2012a] et à l'initiation de certaines activités principales telles que le road-show. Dans le courant des deuxième et troisième trimestres, nous nous sommes focalisés sur le renforcement des capacités des acteurs locaux ainsi que sur les activités de diagnostic telles que le test de la grille de légalité et le suivi de la légalité lors de l'exploitation dans les Forêts Communautaires. Pendant cette période, une étude à mi parcours [KERKHOFS, 2012b] a été réalisée. Enfin, les derniers mois du projet ont été consacrés à la finalisation des différentes activités, à l'étude d'état des lieux de sortie du projet [KERKHOFS et al, 2013a] et à la clôture de l'action par des séances de synthèses tenues dans les communautés et des ateliers de restitution. En matière de sensibilisation, en collaboration avec le partenaire local ASTEVI, nous avons organisé des séances de sensibilisation sur « L'illégalité », « Le programme FLEGT et les Accords de Partenariats Volontaires en réponse à l'illégalité » ainsi que sur le « Comité de vigilance1 et la Stratégie Nationale de Contrôle Forestier et Faunique (SNCFF) ». Des séances de réflexion sur le FLEGT et l'APV ont été menées avec les entités de gestion des forêts communautaires et une pièce de théâtre participatif a été mise en scène dans les différentes communautés. Par ailleurs, trois émissions radio portant sur ces thématiques ont été élaborées et diffusées. De plus, divers supports de sensibilisation à destination des acteurs locaux ont été conçus (dépliants, posters, bande dessinée,...), dont certains en collaboration de l'ONG Fédération Camerounaise Terre Vivante (FCTV). Enfin, deux articles scientifiques ont été soumis. Quant au renforcement des capacités de contrôle de la société civile et de l'administration, 2eme axe stratégique du projet AFFC, des formations ont été dispensées portant sur l’ « Initiation à l'informatique et l'encodage des données d'exploitation », le « Remplissage des documents sécurisés », la « Traçabilité », l' « Utilisation du GPS et de la boussole » ainsi que sur le « Suivi, contrôle et observation indépendante des forêts ». Afin de contribuer à la mise en place d'un système de contrôle, le projet a pris soin de sensibiliser les communautés à la création d'un comité de vigilance, à informer les acteurs locaux quant à la stratégie nationale de contrôle et à appuyer la mise en place d'un système de traçabilité interne aux FC. Enfin, toutes les études de diagnostic prévues ont été réalisées, à savoir les « Tests de la grille de légalité dans 30 FC du Haut Nyong », le « Suivi de l'exploitation dans 6 forêts communautaires » et le « Test du système de traçabilité dans 3 forêts communautaires ». [less ▲]

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See detailNominal group technique to select attributes for discrete choice experiments: an example for drug treatment choice in osteoporosis.
Hiligsmann, Mickaël ULg; van Durme, Caroline; Geusens, Piet et al

in Patient preference and adherence (2013), 7

BACKGROUND: Attribute selection represents an important step in the development of discrete-choice experiments (DCEs), but is often poorly reported. In some situations, the number of attributes identified ... [more ▼]

BACKGROUND: Attribute selection represents an important step in the development of discrete-choice experiments (DCEs), but is often poorly reported. In some situations, the number of attributes identified may exceed what one may find possible to pilot in a DCE. Hence, there is a need to gain insight into methods to select attributes in order to construct the final list of attributes. This study aims to test the feasibility of using the nominal group technique (NGT) to select attributes for DCEs. METHODS: Patient group discussions (4-8 participants) were convened to prioritize a list of 12 potentially important attributes for osteoporosis drug therapy. The NGT consisted of three steps: an individual ranking of the 12 attributes by importance from 1 to 12, a group discussion on each of the attributes, including a group review of the aggregate score of the initial rankings, and a second ranking task of the same attributes. RESULTS: Twenty-six osteoporotic patients participated in five NGT sessions. Most (80%) of the patients changed their ranking after the discussion. However, the average initial and final ranking did not differ markedly. In the final ranking, the most important medication attributes were effectiveness, side effects, and frequency and mode of administration. Some (15%) of the patients did not correctly rank from 1 to 12, and the order of attributes did play a role in the ranking. CONCLUSION: The NGT is feasible for selecting attributes for DCEs. Although in the context of this study, the NGT session had little impact on prioritizing attributes, this approach is rigorous, transparent, and improves the face validity of DCEs. Additional research in other contexts (different decisional problems or different diseases) is needed to determine the added value of the NGT session, to assess the optimal ranking/rating method with control of ordering effects, and to compare the attributes selected with the different approaches. [less ▲]

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See detailTreatment of osteoporosis in men.
Kaufman, JM; Reginster, Jean-Yves ULg; Boonen, S et al

in BONE (2013), 53(1), 134-44

SUMMARY: Aspects of osteoporosis in men, such as screening and identification strategies, definitions of diagnosis and intervention thresholds, and treatment options (both approved and in the pipeline ... [more ▼]

SUMMARY: Aspects of osteoporosis in men, such as screening and identification strategies, definitions of diagnosis and intervention thresholds, and treatment options (both approved and in the pipeline) are discussed. INTRODUCTION: Awareness of osteoporosis in men is improving, although it remains under-diagnosed and under-treated. A European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) workshop was convened to discuss osteoporosis in men and to provide a report by a panel of experts (the authors). METHODS: A debate with an expert panel on preselected topics was conducted. RESULTS AND CONCLUSIONS: Although additional fracture data are needed to endorse the clinical care of osteoporosis in men, consensus views were reached on diagnostic criteria and intervention thresholds. Empirical data in men display similarities with data acquired in women, despite pathophysiological differences, which may not be clinically relevant. Men should receive treatment at a similar 10-year fracture probability as in women. The design of mixed studies may reduce the lag between comparable treatments for osteoporosis in women becoming available in men. [less ▲]

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See detailHypovitaminosis D and osteoporosis in burn patients: are the current practices enough ?
ROUSSEAU, Anne-Françoise ULg; LEDOUX, Didier ULg; DAMAS, Pierre ULg et al

in Osteoporosis International (2013), 24(Suppl 1), 377

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See detailVitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).
Rizzoli, R.; Boonen, S.; Brandi, M.-L. et al

in Current Medical Research & Opinion (2013), 29(4), 1-9

Abstract Background: Vitamin D insufficiency has deleterious consequences on health outcomes. In elderly or postmenopausal women, it may exacerbate osteoporosis. Scope: There is currently no clear ... [more ▼]

Abstract Background: Vitamin D insufficiency has deleterious consequences on health outcomes. In elderly or postmenopausal women, it may exacerbate osteoporosis. Scope: There is currently no clear consensus on definitions of vitamin D insufficiency or minimal targets for vitamin D concentrations and proposed targets vary with the population. In view of the potential confusion for practitioners on when to treat and what to achieve, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) convened a meeting to provide recommendations for clinical practice, to ensure the optimal management of elderly and postmenopausal women with regard to vitamin D supplementation. Findings: Vitamin D has both skeletal and extra-skeletal benefits. Patients with serum 25-hydroxyvitamin D (25-(OH)D) levels <50 nmol/L have increased bone turnover, bone loss, and possibly mineralization defects compared with patients with levels >50 nmol/L. Similar relationships have been reported for frailty, nonvertebral and hip fracture, and all-cause mortality, with poorer outcomes at <50 nmol/L. Conclusion: The ESCEO recommends that 50 nmol/L (i.e. 20 ng/mL) should be the minimal serum 25-(OH)D concentration at the population level and in patients with osteoporosis to ensure optimal bone health. Below this threshold, supplementation is recommended at 800 to 1000 IU/day. Vitamin D supplementation is safe up to 10,000 IU/day (upper limit of safety) resulting in an upper limit of adequacy of 125 nmol/L 25-(OH)D. Daily consumption of calcium- and vitamin-D-fortified food products (e.g. yoghurt or milk) can help improve vitamin D intake. Above the threshold of 50 nmol/L, there is no clear evidence for additional benefits of supplementation. On the other hand, in fragile elderly subjects who are at elevated risk for falls and fracture, the ESCEO recommends a minimal serum 25-(OH)D level of 75 nmol/L (i.e. 30 ng/mL), for the greatest impact on fracture. [less ▲]

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See detailEuropean guidance for the diagnosis and management of osteoporosis in postmenopausal women.
Kanis, J. A.; McCloskey, E. V.; Johansson, H. et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2013), 24(1), 23-57

Guidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk of fractures due to osteoporosis. INTRODUCTION: The International Osteoporosis Foundation and ... [more ▼]

Guidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk of fractures due to osteoporosis. INTRODUCTION: The International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis published guidance for the diagnosis and management of osteoporosis in 2008. This manuscript updates these in a European setting. METHODS: Systematic literature reviews. RESULTS: The following areas are reviewed: the role of bone mineral density measurement for the diagnosis of osteoporosis and assessment of fracture risk, general and pharmacological management of osteoporosis, monitoring of treatment, assessment of fracture risk, case finding strategies, investigation of patients and health economics of treatment. CONCLUSIONS: A platform is provided on which specific guidelines can be developed for national use. [less ▲]

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See detailMacrocyle-embedded b-lactams as novel inhibitors of the Penicillin Binding Protein PBP2a from MRSA
Dive, Georges ULg; Bouillon, Camille; Sliwa, Aline et al

in European Journal of Medicinal Chemistry (2013), 64

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See detailIdentification and typing of Salmonella serotypes isolated from guinea fowl (Numida meleagris) farms in Benin during four laying seasons (2007-2010)
Boko, C; Kpodekon, T; Duprez, Jean-Noël ULg et al

in Avian Pathology : Journal of the W.V.P.A (2013), 42

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See detailAmélioration des bilans d'excrétion d'azote dans deux exploitations laitières de la région wallonne par un suivi raisonné des rations
Knapp, Emilie ULg; Istasse, Louis ULg; Hornick, Jean-Luc ULg et al

in Vandenberghe, Christophe; Colinet, Gilles; Destain, Jean-Pierre (Eds.) et al 2ème Atelier Nitrate-Eau, évaluation du programme de gestion durable de l'azote (2013)

Deux exploitations laitières situées l'une en Pays de Herve et l'autre en Ardenne ont fait l'objet de suivis réalisés en vue de déterminer les bilans d'excrétion azotée. Dans la première exploitation, les ... [more ▼]

Deux exploitations laitières situées l'une en Pays de Herve et l'autre en Ardenne ont fait l'objet de suivis réalisés en vue de déterminer les bilans d'excrétion azotée. Dans la première exploitation, les vaches étaient divisées en deux groupes, à savoir le groupes de hautes productrices (HP) et le groupe des basses productrices (BP), chaque groupe recevant une ration spécifique. Dans la seconde exploitation, les animaux constituaient un seul groupe. [less ▲]

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See detailLower intracellular concentration of cryoprotectants after vitrification than after slow freezing despite exposure to higher concentration of cryoprotectant solutions.
Vanderzwalmen, P.; Connan, Delphine ULg; Grobet, Luc ULg et al

in Human reproduction (Oxford, England) (2013)

STUDY QUESTION: What is the intracellular concentration of cryoprotectant (ICCP) in mouse zygotes during vitrification (VIT) and slow-freezing (SLF) cryopreservation procedures? SUMMARY ANSWER: Contrary ... [more ▼]

STUDY QUESTION: What is the intracellular concentration of cryoprotectant (ICCP) in mouse zygotes during vitrification (VIT) and slow-freezing (SLF) cryopreservation procedures? SUMMARY ANSWER: Contrary to common beliefs, it was observed that the ICCP in vitrified zygotes is lower than after SLF, although the solutions used in VIT contain higher concentrations of cryoprotectants (CPs). WHAT IS KNOWN ALREADY: To reduce the likelihood of intracellular ice crystal formation, which has detrimental effects on cell organelles and membranes, VIT was introduced as an alternative to SLF to cryopreserve embryos and gametes. Combined with high cooling and warming rates, the use of high concentrations of CPs favours an intracellular environment that supports and maintains the transition from a liquid to a solid glass-like state devoid of crystals. Although the up-to-date publications are reassuring in terms of obstetric and perinatal outcomes after VIT, a fear about exposing gametes and embryos to high amounts of CPs that exceed 3-4-fold those found in SLF was central to a debate initiated by advocates of SLF procedures. STUDY DESIGN, SIZE, DURATION: Two experimental set-ups were applied. The objective of a first study was to determine the ICCP at the end of the exposure steps to the CP solutions with our VIT protocol (n = 31). The goal of the second investigation was to compare the ICCP between VIT (n = 30) and SLF (n = 30). All experiments were performed in triplicates using mouse zygotes. The study took place at the GIGA-Research Institute of the University of Liege. PARTICIPANTS/MATERIALS, SETTING, METHODS: Cell volume is modified by changes in extracellular osmolarity. Hence, we estimated the final ICCP after the incubation steps in the VIT solutions by exposing the cells to sucrose (SUC) solutions with defined molarities. The ICCP was calculated from the SUC concentration that produced no change in cell volume, i.e. when intra- and extracellular osmolarities were equivalent. Cell volume was monitored by microscopic cinematography. ICCP was compared between SLF and VIT based on the principle that a high ICCP lowers the probability of (re)crystallization during warming but increases the probability of over-swelling of the cell due to fast inflow of water. The survival rates of mouse zygotes after SLF or VIT were compared using either (i) various warming rates or (ii) various concentrations of SUC in the warming dilution medium. MAIN RESULTS AND THE ROLE OF CHANCE: The ICCP in mouse zygotes during the VIT procedure prior to plunging them in liquid nitrogen was approximately 2.14 M, i.e. one-third of the concentration in the VIT solution. After SLF, the warming rate did not affect the zygote survival rate. In contrast, only 3/30 vitrified zygotes survived when warmed slowly but as many as 30/30 zygotes survived when warming was fast (>20 000 degrees C/min). Vitrified zygotes showed significantly higher survival rates than slow-frozen zygotes when they were placed directly in the culture medium or in solutions containing low concentrations of SUC (P < 0.01). These two experiments demonstrate a lower ICCP after VIT than after SLF. LIMITATIONS, REASONS FOR CAUTION: The results should not be directly extrapolated to other stages of development or to other species due to possible differences in membrane permeability to water and CPs. WIDER IMPLICATIONS OF THE FINDINGS: The low ICCP we observed after VIT removes the concern about high ICCP after VIT, at least in murine zygotes and helps to explain the observed efficiency and lack of toxicity of VIT. STUDY FUNDING / COMPETING INTEREST(S): The study was funded by the FNRS (National Funds for Scientific Research). The authors declare that they have no competing interests. [less ▲]

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See detailHigher risk of death among MEN1 patients with mutations in the JunD interacting domain. A Groupe d'étude des Tumeurs Endocrines (GTE) cohort study
Thevenon, Julien; Bourredjem, Abderrahmane; Faivre, Laurence et al

in Human Molecular Genetics (2013)

BackgroundMultiple Endocrine Neoplasia syndrome type 1 (MEN1), which is secondary to mutation of the MEN1 gene, is a rare autosomal-dominant disease that predisposes mutation carriers to endocrine tumors ... [more ▼]

BackgroundMultiple Endocrine Neoplasia syndrome type 1 (MEN1), which is secondary to mutation of the MEN1 gene, is a rare autosomal-dominant disease that predisposes mutation carriers to endocrine tumors. Although genotype-phenotype studies have so far failed to identify any statistical correlations, some families harbor recurrent tumor patterns. The function of MENIN is unclear but has been described through the discovery of its interacting partners. Mutations in the interacting domains of MENIN functional partners have been shown to directly alter its regulation abilities.MethodsWe report on a cohort of MEN1 patients from the Groupe d'etude des Tumeurs Endocrines. Patients with a molecular diagnosis and a clinical follow-up, totalling 262 families and 806 patients were included. Associations between mutation type, location or interacting factors of the MENIN protein and death as well as the occurrence of MEN1-related tumors were tested using a frailty Cox model to adjust for potential heterogeneity across families.ResultsAccounting for the heterogeneity across families, the overall risk of death was significantly higher when mutations affected the JunD interacting domain (adjusted HR=1.88: 95%-CI=1.15- 3.07). Patients had a higher risk of death from cancers of the MEN1 spectrum (HR=2.34; 95%-CI=1.23- 4.43).ConclusionThis genotype-phenotype correlation study confirmed the lack of direct genotype-phenotype correlations. However, patients with mutations affecting the JunD interacting domain had a higher risk of death secondary to a MEN1 tumor and should thus be considered for surgical indications, genetic counseling and follow-up. [less ▲]

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See detailPhysico-chemical and membrane-interacting properties of D-xylose-based bolaforms. Influence of the anomeric configuration
Nasir, Mehmet Nail ULg; Legrand, Vincent; Gatard, Sylvain et al

in MATEC Web of Conferences (2013), ACCEPTED

Sugar-based biosurfactants such as xylose-derived bolaforms have interesting properties, for example high biocompatibility and biodegradability which make them potential useful molecules in the ... [more ▼]

Sugar-based biosurfactants such as xylose-derived bolaforms have interesting properties, for example high biocompatibility and biodegradability which make them potential useful molecules in the pharmaceutical and cosmetic fields. Until now, no detailed analyses of the physico-chemical properties of these compounds have been undertaken. Two symmetrical D-xylose-based bolaforms were chemically synthesized where the two xylose heads are linked via an acetal link to a hydrocarbon chain containing 18 carbon atoms and an unsaturation. The two bolaforms differ only by their anomeric configuration: or The bolaform exhibits interfacial properties at the air-water interface which is not the case for the . FTIR spectroscopy showed that the interactions between the bolaform and POPC, a model phospholipid, involve the carbonyl groups of the phospholipid [less ▲]

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See detailThe Role of Aryl Hydrocarbon Receptor (AHR) and AHR-Interacting Protein (AIP) in the Pathogenesis of Pituitary Adenomas
Jaffrain Rea, ML; Beckers, Albert ULg

in Hayat, MA (Ed.) Tumors of the Central nervous system (2013)

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See detailFamilial Pituitary Adenomas : An overview
Vasilev, V; Daly, Adrian ULg; Beckers, Albert ULg

in Hayat, MA (Ed.) Tumors of the Central nervous system (2013)

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See detailTowards fracture prediction in single point incremental forming
Guzmán Inostroza, Carlos Felipe ULg; Habraken, Anne ULg

in Key Engineering Materials [=KEM] (2013), 554-557

The stress state in metal forming processes usually implies low values of triaxiality. It is well known that damage models based only on triaxiality fails to capture the damage behavior properly, and ... [more ▼]

The stress state in metal forming processes usually implies low values of triaxiality. It is well known that damage models based only on triaxiality fails to capture the damage behavior properly, and recent articles have stressed the effect of the Lode parameter in describing damage. Moreover, in some process like incremental forming, the through thickness shear could dominate the rupture mechanism making the description, using solely the triaxiality, inaccurate. In this paper, a preliminary study of the stress state is carried over a near-to-failure single point incremental forming (SPIF) formed cone, through finite elements simulations using a newly developed solid-shell element. The results provide a basis for further studies into damage development in SPIF. [less ▲]

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See detailLes récusations
Moreau, Pierre ULg

in L'instance (2013)

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See detailException de la caution de l'étranger demandeur
Moreau, Pierre ULg

in L'instance (2013)

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