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See detailRisk Assessment of Florists Exposed to Pesticide Residues through Handling of Flowers and Preparing Bouquets
Toumi, Khaoula ULg; Laure, Joly; Vleminckx, Christiane et al

in International Journal of Environmental Research and Public Health (2017), 14(5)

Abstract: Flowers are frequently treated with pesticides and, as a result, florists handling daily a large number of flowers can be exposed to pesticide residues. A study was conducted among twenty ... [more ▼]

Abstract: Flowers are frequently treated with pesticides and, as a result, florists handling daily a large number of flowers can be exposed to pesticide residues. A study was conducted among twenty volunteer florists located in Namur Province and in the Brussels Capital Region of Belgium in order to assess their potential dermal exposure to dislodgeable pesticide residues transferred from flowers to hands. Two pairs of cotton gloves were worn during two consecutive half days while handling flowers and preparing bouquets (from min 2 h to max 3 h/day). The residual pesticide deposits on the glove samples were extracted with a multi-residue Quick Easy Cheap Effective Rugged Safe (QuEChERS) method and analyzed by a combination of gas and liquid chromatography tandem mass spectrometry (GC-MS/MS and LC-MS/MS) by an accredited laboratory. A total of 111 active substances (mainly insecticides and fungicides) were detected, with an average of 37 active substances per sample and a total concentration per glove sample of 22.22 mg/kg. Several predictive levels of contamination were considered to assess the risk. The potential dermal exposures (PDE) of florists were estimated at the average, for different percentiles, and at the maximum concentration of residues in samples. At the PDE P90 and at the PDEMAX (or worst case) values, three and five active substances respectively exceed the Acceptable Operator Exposure Level (AOEL), indicating risk situations. For the systemic exposure (SE), one active substance (clofentezine) exceeds the AOEL at the P90 predictive level. In the worst case, SEMAX (at the maximum concentrations), four active substances (clofentezine, famoxadone, methiocarb, and pyridaben) exceed their respective AOEL values. Among the 14 most frequently detected active substances, two have SEMAX values exceeding the AOEL. Exposure could be particularly critical for clofentezine with an SEMAX value four times higher than the AOEL (393%). The exposure of florists appeared to be an example of a unique professional situation in which workers are exposed regularly to both a very high number of toxic chemicals and rather high concentration levels. Therefore the priority should be to raise the level of awareness among the florists who must change their habits and practices if they want to minimize their exposure. [less ▲]

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See detailLes statines, cas d'école de surprescrption ?
Henrard, Gilles ULg

Scientific conference (2017, May 13)

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See detailHow to count leaves in the trees from Tetris?
Vandomme, Elise ULg

Conference (2017, May 13)

In the world derived from the game Tetris, what is a tree? How many leaves can such a tree can have? What happens if instead, we consider the world derived from the game Minecraft? Can we generalise this ... [more ▼]

In the world derived from the game Tetris, what is a tree? How many leaves can such a tree can have? What happens if instead, we consider the world derived from the game Minecraft? Can we generalise this problem in other worlds? Does there exist an efficient algorithm to determine the maximal number of leaves a tree can have? These are the questions we will answer in this talk, using the point of view of graph theory. To determine the complexity of the problem, we will use some dynamical programming. [less ▲]

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See detailBelgian speleothem records Holocene cold events?
Allan, Mohammed ULg; Deliège, Adrien ULg; Nicolay, Samuel ULg et al

Poster (2017, May 12)

Speleothem is now regarded as valuable archive of climatic conditions on the continents, offering a number of advantages relative to other continental climate proxy recorders such as lake sediments and ... [more ▼]

Speleothem is now regarded as valuable archive of climatic conditions on the continents, offering a number of advantages relative to other continental climate proxy recorders such as lake sediments and peat cores. High spatial resolution measurements of Mg, Al, Sr, Ba were realized by using laser-ablation inductively coupled plasma mass spectrometry in the Belgian Pere Noel cave. A stalagmite from the Pere Noel (PN) cave representing 12000 years dated by U/Th method. Trace element variations in speleothem are a reflection of hydrochemical conditions. These changes were interpreted as indications of changes in climate in the Han-sur-Lesse region. The similar patterns found in δ 18O, δ 13C and chemical composition along the Pere Noel stalagmite suggests that trace elements in speleothems have the potential to provide high resolution insights into palaeoclimatic variability during the Holocene. A deeper analysis reveals several periods of significant rapid climate change during the Holocene (at 10.7-9.2 ka, 8.2-7.9 ka, 7.2-6.2 ka, 4.8-4.5 ka, and 3-2.4 ka BP), which are similar to the cold events detected from different natural paleoclimate archivers. A comparison between the geochemical analysis of Père Noël speleothem and solar activity (sunspot number) reveals a significant correlation. Spectral analysis methods reveal common solar periodicities (Gleissberg cycle, de Vries cycle, unnamed 500 year, Eddy cycles, and Hallstatt cycle). The geochemical analyses have the potential to prove that PN speleothem is sensitive to changes in solar activity on centennial and millennial timescales during the Holocene. [less ▲]

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See detailRecovering unlawful advantages in the context of EU State aid tax ruling investigations
Van Cleynenbreugel, Pieter ULg

in Market and Competition Law Review (2017), 1(1), 15-48

The European Commission has recently begun to focus increasingly on the compatibility of Member States’ tax ruling procedures with EU State aid law. In that respect, it has ordered the recovery of ... [more ▼]

The European Commission has recently begun to focus increasingly on the compatibility of Member States’ tax ruling procedures with EU State aid law. In that respect, it has ordered the recovery of unlawfully granted advantages through those procedures. This article examines to what extent the application of EU law principles of legitimate expectations and legal certainty are to take stock in State aid recovery proceedings of this particular legal certainty-enhancing and legitimate expectationscreating tax ruling context. It additionally questions whether recovery in this particular context should be tailored to the specific national ruling framework having resulted in the advantage granted in violation of Article 107 TFEU [less ▲]

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See detailTime perspective and emotional future-oriented thoughts
Barsics, Catherine ULg

Conference (2017, May 12)

Time perspective —the tendency to focus on the past, present, and/or future— has a pervasive influence on many aspects of human cognition and behaviour, such as decision making, planning, motivation, self ... [more ▼]

Time perspective —the tendency to focus on the past, present, and/or future— has a pervasive influence on many aspects of human cognition and behaviour, such as decision making, planning, motivation, self-regulation, and sense of identity. Over the last decade, important progress has been made in understanding the representations and processes that support our ability to mentally explore possible futures. More particularly, many thoughts and mental images that people form about their personal future refer to emotionally significant events. Such emotional future-oriented thoughts (EmoFTs) were studied in natural settings and under laboratory conditions. The results showed that EmoFTs are frequent, occur in various contexts, and are perceived to fulfill important functions, mostly related to goal pursuit and emotion regulation. The phenomenological characteristics of EmoFTs (e.g., representational format) vary according to valence. When distinguishing between anticipatory and anticipated emotions (i.e., emotions experienced in the present versus emotions expected to occur in the future), a positivity bias in the frequency of EmoFTs is found to be restricted to anticipated emotions. These findings shed further light on the properties of future oriented-thoughts, and emphasize the importance of their affective components. [less ▲]

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See detailComparative Feeding Ecology of Cardinalfishes (Apogonidae) at Toliara Reef, Madagascar
Frederich, Bruno ULg; Michel, Loïc ULg; Zaeytydt, Esther et al

in Zoological Studies (2017), 56(10), 1-14

Despite their importance in coral reef ecosystem function and trophodynamics, the trophic ecology of nocturnal fishes (e.g. Apogonidae, Holocentridae, Pempheridae) is by far less studied than diurnal ones ... [more ▼]

Despite their importance in coral reef ecosystem function and trophodynamics, the trophic ecology of nocturnal fishes (e.g. Apogonidae, Holocentridae, Pempheridae) is by far less studied than diurnal ones. The Apogonidae (cardinalfishes) include mostly carnivorous species and evidence of trophic niche partitioning among sympatric cardinalfishes is still limited. The present study combines stomach contents and stable isotope analyses to investigate the feeding ecology of an assemblage of eight cardinalfishes from the Great Reef of Toliara (SW Madagascar). δ13C and δ15N of fishes ranged between -17.49‰ and -10.03‰ and between 6.28‰ and 10.74‰, respectively. Both stomach contents and stable isotopes showed that they feed on planktonic and benthic animal prey in various proportions. Previous studies were able to group apogonids in different trophic categories but such a discrimination is not obvious here. Large intra-specific variation in the stomach contents and temporal variation in the relative contribution of prey to diet support that all apogonids should be considered as generalist, carnivorous fishes. However the exploration of the isotopic space revealed a clear segregation of isotopic niches among species, suggesting a high level of resource partitioning within the assemblage. According to low inter-specific variation in stomach content compositions, we argue that the differences in isotopic niches could be driven by variation in foraging locations (i.e. microhabitat segregation) and physiology among species. Our temporal datasets demonstrate that the trophic niche partitioning among cardinalfishes and the breadth of their isotopic niches are dynamic and change across time. Factors driving this temporal variation need to be investigated in further studies. [less ▲]

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See detailÀ la recherche d"une réalité "vraie" : entre peur métaphysique et angoisse dans l'autofiction (néo)fantastique hispano-américaine
Licata, Nicolas ULg

Conference (2017, May 12)

Après avoir déterminé les limites que lui concèdent des disciplines comme l’histoire des émotions, la psychanalyse et la philosophie, cette communication se centre sur la peur comme effet de la ... [more ▼]

Après avoir déterminé les limites que lui concèdent des disciplines comme l’histoire des émotions, la psychanalyse et la philosophie, cette communication se centre sur la peur comme effet de la littérature fantastique, et plus concrètement dans le cadre de cette catégorie spécifique de romans que Vincent Colonna a baptisé « autofiction fantastique ». À la lumière de trois de ces fictions fantastiques modernes articulées autour de leurs propres auteurs, nous expliquerons pourquoi, à notre avis, l’effet qu’elles produisent chez le lecteur diffère de la peur. Il ne s’agit pas d’un effet inférieur ni supérieur, mais simplement différent : l’angoisse. [less ▲]

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See detailNGS for NBS : Are we ready for « Next Generation » Newborn Screening ?
BOEMER, François ULg

Conference (2017, May 12)

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See detailAux frontières du réel : de l’immersion aux formes de jeu « secondaire »
Delbouille, Julie ULg; Hurel, Pierre-Yves ULg; Barnabé, Fanny ULg et al

Conference (2017, May 12)

Dans les sciences du jeu, la problématique du franchissement de la frontière qui nous sépare des mondes virtuels se cristallise particulièrement à travers le concept d’immersion. S’il est constamment ... [more ▼]

Dans les sciences du jeu, la problématique du franchissement de la frontière qui nous sépare des mondes virtuels se cristallise particulièrement à travers le concept d’immersion. S’il est constamment employé pour étudier le rapport que le joueur entretient avec le jeu, il reste cependant peu problématisé ; plus encore, son omniprésence et l’hétérogénéité (parfois contradictoire) de ses définitions empêche de penser l’acte de joueur en dehors du prisme de ce paradigme. Cette communication vise, d’une part, à souligner les limites et les écueils de l’emploi de ce concept au sein des game studies et, d’autre part, à mettre en lumière des pratiques que l’immersion a, jusqu’à présent, contribué à reléguer au second plan de la recherche. [less ▲]

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See detailNouvelles combinaisons thérapeutiques pour améliorer l'efficacité anti-tumorale de l'inhibition d'HDAC5
Hendrick, Elodie ULg

Doctoral thesis (2017)

En oncologie, les 18 membres de la famille des déacétylases d’histone (HDAC) représentent des cibles thérapeutiques d’intérêt croissant. En effet, de nombreuses molécules pharmacologiques ciblant ... [more ▼]

En oncologie, les 18 membres de la famille des déacétylases d’histone (HDAC) représentent des cibles thérapeutiques d’intérêt croissant. En effet, de nombreuses molécules pharmacologiques ciblant l’activité enzymatique de ces protéines (HDACi) montrent des effets anti-tumoraux intéressants in vitro et in vivo ainsi que dans de nombreux essais cliniques sur des patients souffrant de pathologies cancéreuses solides et hématologiques. A ce jour, 4 de ces molécules (Vorinostat®, l’Istodax®, Beleodaq® et le Farydak®) sont d’ailleurs approuvées par la FDA et l’EMA pour le traitement de patients souffrant, notamment, de différents types de lymphomes et de myélomes. Aujourd’hui, les oncologues s’intéressent au développement d’inhibiteurs d’HDAC plus sélectifs avec comme objectifs de maintenir et d’améliorer l’effet anti-tumoral tout en diminuant la toxicité et en réduisant les potentiels effets non désirés. Dans cette optique, il convient de déterminer plus finement les relations qu’il existe entre l’inhibition spécifique d’une HDAC et les effets anti- tumoraux observés et ce, afin d’identifier la (les) HDAC d’intérêt à cibler en thérapie anti-cancéreuse. Dans ce travail, nous nous sommes focalisés sur le rôle et les mécanismes d’action de l’histone déacétylase 5 (HDAC5) dans les cellules cancéreuses. Nos résultats démontrent que l’inhibition sélective d’HDAC5 module l’expression de protéines du complexe I de la chaîne respiratoire mitochondriale, de protéines pro- et anti- oxydantes et des protéines impliquées dans le métabolisme de métaux tel que le métabolisme de stockage du fer labile. Par conséquent, la déplétion d’HDAC5 induit une production accrue d’espèces réactives de l’oxygène (ROS) mitochondriaux accentués par la présence accrue de fer labile intracellulaire disponible pour la réaction de Fenton. Cette accumulation accrue de ROS induit une mort cellulaire par apoptose et un processus d’autophagie de type mitophagie (dégradation sélective des mitochondries endommagées et productrice de ROS). La déplétion d’HDAC5 dans des cellules cancéreuses modifie également le métabolisme énergétique dépendant du glucose et de la glutamine. Nous avons effectivement observé d’une part, une augmentation de l’import du glucose dirigé vers la voie des pentoses phosphates assurant une production de NADPH, force réductrice du glutathion permettant ainsi de contrecarrer le stress oxydant et d’autre part, une glutamino-dépendance nécessaire au maintien des besoins énergétiques de la cellule. Par conséquent, des cellules déplétées en HDAC5 dont l’apport en glucose ou en glutamine est contrecarré par des inhibiteurs métaboliques utilisés en clinique, meurent de manière significative par apoptose in vitro et diminuent la croissance de tumeurs in vivo, suggérant que des stratégies combinatoires couplant l’inhibition sélective d’HDAC5 à des inhibiteurs du métabolisme énergétique actuellement testés en essai clinique pourraient être proposées comme nouvelle stratégie combinatoire en thérapie anti-cancéreuse. [less ▲]

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See detailBasic Helix loop Helix transcription factor twist1a and twist1b and their involvement in the skeletal development of zebrafish
Zappia, Jérémie ULg

Conference (2017, May 12)

1. Objective The twist1a and twist1b genes code for transcription factors involved during embryogenesis in the craniofacial development. The human ortholog of twist1a and twist1b, TWIST1 has been shown to ... [more ▼]

1. Objective The twist1a and twist1b genes code for transcription factors involved during embryogenesis in the craniofacial development. The human ortholog of twist1a and twist1b, TWIST1 has been shown to be mutated in cases of the Saethre–Chotzen syndrome (SCS). However, the roles of these genes in skeletal development in zebrafish remain to be clarified. The aim of our research is to characterize the effects of the knock-down of twist1a and twist1b in the zebrafish. 2. Methods Antisens morpholino are used for the knock-down of twist1a and twist1b (respectively MoTwist1a and MoTwist1b). The sox9a expression is investigated using whole amount in situ hybridization. 3. Results We show the spatio-temporal expression pattern of twist1a and twist1b during the first 6 days of zebrafish development and present the effects observed on cartilage and bone formation upon knock-down of these genes in zebrafish larvae. The results reveal a decrease of the cranial cartilage and bone formation in both MoTwist1a and MoTwist1b. Interestingly, when MoTwist1a and MoTwist1b are co-injected, the cranial cartilage formation is strongly reduced, while ectopic cartilage formation appeared in the front of the head. We also show an increase in expression of sox9a, a master regulator of chondrogenesis, in morphants. 4. Summary and Conclusions Even though it was shown that twist1a and twist1b maintain a pool of osteoprogenitor-like cells, we show that a knock-down of these genes induces a decrease of skeletal formation. Our hypothesis is that the morphants run out of progenitor cells to assure correct bone and cartilage formation. In the future, we plan to generate twist1a mutants in order to further characterize the effect of this mutation. The twist1a mutant will eventually serve for a rescue study using human TWIST1 mRNA, wild-type or mutant in order to have a better understanding of the human disorder SCS. [less ▲]

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See detailL'APL en région wallonne. Référence et contrôle : méthodologie et résultats
Vandenberghe, Christophe ULg

Conference (2017, May 11)

En région wallonne (Belgique), des contrôles sont chaque année organisés en vue de mesurer l'azote nitrique présent dans les parcelles d'agriculteurs situés en zone vulnérable. Les résultats de ces ... [more ▼]

En région wallonne (Belgique), des contrôles sont chaque année organisés en vue de mesurer l'azote nitrique présent dans les parcelles d'agriculteurs situés en zone vulnérable. Les résultats de ces mesures sont comparés à des références annuelles établies pour huit classes d'occupation de sol.En 2016, les références établies par Gembloux Agro-Bio Tech (ULiège) et l'UCL se sont appuyées sur des observations réalisées dans plus de 250 parcelles distribuées dans 41 exploitations agricoles encadrées en matière de gestion de l'azote. Le Service Public de Wallonie a fait contrôler environ 2000 parcelles par des laboratoires agréés. De l'ordre de 80% des exploitations contrôlées ont présenté des résultats conformes. [less ▲]

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See detailCrosstalk between VEGF and BMP9 pathway. Implications in HHT disease
Pollenus, Thomas ULg

Poster (2017, May 11)

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