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See detailRedrawing Comics into the Graphic Novel: the Historiography of Comics, Canonization, and Authors’ Histories of the Medium
Crucifix, Benoît ULg

Conference (2016, May 26)

The development of comics studies in the United States has been linked to the institutionalization of the ‘graphic novel’ as a ‘literary’ subset of comics deemed worthy of academic attention. Several ... [more ▼]

The development of comics studies in the United States has been linked to the institutionalization of the ‘graphic novel’ as a ‘literary’ subset of comics deemed worthy of academic attention. Several voices in North-America are now challenging the need for canon formation by arguing for other approaches to the historiography of comics beyond the graphic novel. Histories and definitions, however, as Thierry Smolderen argues, are not only written by scholars, but generated by a multiplicity of social groups actively participating in the ongoing negotiation of what the medium ‘is’. Drawing on these recent trends, I will engage in a disciplinary reflection on the historiography of comics by focusing on authors' histories of the medium. Cartoonists themselves indeed act as comics historians: suffice to think of Jules Feiffer's pioneering The Great Comic Book Heroes (1965). ‘Graphic novelists’ as Chris Ware, Art Spiegelman, Seth or Daniel Clowes have been deeply engaged in recovering the past of comics in their works as well as in essays, reprints, or exhibitions. These histories are fragmentary, emotionally charged and at times anachronistic, but they complicate teleological accounts of the graphic novel, disrupting the academic canon. Confronting this perspective with recent insights in literary historiography, I will attempt to examine some of the specific epistemological issues raised by cartoonists' histories of comics in their divergence or convergence with other historiographic trends such as fanzines and academic research. [less ▲]

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See detailDESIGN OF HIGH-AFFINITY LIGANDS FOR THE BENZOTHIADIAZINE ALLOSTERIC BINDING SITE OF THE AMPA RECEPTORS
Drapier, Thomas ULg; Geubelle, Pierre ULg; Bouckaert, Charlotte et al

Poster (2016, May 26)

L-glutamic acid is the major excitatory neurotransmitter in the brain. It exerts its effects through metabotropic and ionotropic receptors. Among the latter, three subtypes have been identified: NMDA ... [more ▼]

L-glutamic acid is the major excitatory neurotransmitter in the brain. It exerts its effects through metabotropic and ionotropic receptors. Among the latter, three subtypes have been identified: NMDA, AMPA and KA receptors. It is now well established that a deficit in glutamatergic signaling may be responsible for neurological disorders such as mild cognitive impairment, schizophrenia, depression, and ADHD. Enhancement of the signal through positive allosteric modulators of AMPA receptors might be a therapeutic issue for these diseases. These compounds are expected to exert a fine tuning of the signal. Since they require the presence of the endogenous ligand to be active, they are expected to induce less toxicity than agonists. In this context, based on the structure of known allosteric modulators of AMPA receptors such as cyclothiazide and IDRA 21, the Laboratory of Medicinal Chemistry (University of Liège) has developed a series of 1,2,4-benzothiadiazine 1,1-dioxides with high potency as AMPA receptor potentiators. Crystallographic data obtained by the Department of Drug Design and Pharmacology (University of Copenhagen) highlighted those potentiators bind to two contiguous sites at the dimer interface of the ligand binding domain (LBD) of the AMPA receptor1,2. Based on these data, we may expect that the synthesis of dimeric molecules could lead to further improvement in affinity and activity. This assumption was reinforced by docking experiments conducted with virtual examples of dimeric compounds on the GluA2-LBD (collaboration with NAMEDIC). The present work is thus focusing on the preparation of a family of dimeric benzothiadiazine dioxides. Moreover, in collaboration with GIGA-Molecular Pharmacology, we are developing a pharmacological in vitro assay based on the measurement of Ca2+ inflow through a fluorimetric method. This medium-throughput screening will enable the characterization of our new compounds and the validation of our working hypothesis. [less ▲]

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See detailUse of Estetrol with other Steroids for Attenuation of Neonatal Hypoxic-Ischemic brain injury:to combine or not to combine?
Tskitishvili, Ekaterine ULg; Pequeux, Christel ULg; Munaut, Carine ULg et al

in Oncotarget (2016)

Estetrol (E4), estradiol (E2) and progesterone (P4) have important antioxidative and neuroprotective effects in neuronal system. We aimed to study the consequence of combined steroid therapy in neonatal ... [more ▼]

Estetrol (E4), estradiol (E2) and progesterone (P4) have important antioxidative and neuroprotective effects in neuronal system. We aimed to study the consequence of combined steroid therapy in neonatal hypoxic-ischemic encephalopathy (HIE). In vitro the effect of E4 combined with other steroids on oxidative stress and the cell viability in primary hippocampal cultures was evaluated by lactate dehydrogenase and cell survival assays. In vivo neuroprotective and therapeutic efficacy of E4 combined with other steroids was studied in HIE model of immature rats. The rat pups rectal temperature, body and brain weights were evaluated. The hippocampus and the cortex were investigated by histo/immunohistochemistry: intact cell number counting, expressions of markers for early gray matter lose, neuro- and angiogenesis were studied. Glial fibrillary acidic protein was evaluated by ELISA in blood samples. In vitro E4 and combinations of high doses of E4 with P4 and/or E2 significantly diminished the LDH activity and upregulated the cell survival. In vivo pretreatment or treatment by different combinations of E4 with other steroids had unalike effects on body and brain weight, neuro- and angiogenesis, and GFAP expression in blood. The combined use of E4 with other steroids has no benefit over the single use of E4. [less ▲]

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See detailNumerical Modeling and Experimental Identification of Mistuned Multi-Stage Bladed Assemblies
Nyssen, Florence ULg

Doctoral thesis (2016)

In turbomachinery, low pressure compressors are composed of a succession of bladed disks. To reduce the mass and increase the performance of the aircraft engines, one-piece multi-stage units of bladed ... [more ▼]

In turbomachinery, low pressure compressors are composed of a succession of bladed disks. To reduce the mass and increase the performance of the aircraft engines, one-piece multi-stage units of bladed disks have been recently developed. But these one-piece technologies are challenging for the mechanical design due to exacerbated effects of mistuning (i.e., mode localization and forced response amplification). In the thesis, an experimental method for the identification of mistuning in multi-stage bladed structures is proposed and validated. Numerical modeling methods are proposed to reduce computational times for the statistical predictions of the forced response amplification. A characterization of the interstage coupling is performed and a criterion is proposed to predict in advance if a multi-stage analysis is necessary. [less ▲]

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See detailIn situ and laboratory mechanical characterization of a loess sequence from Middle Belgium
Delvoie, Simon ULg; Charlier, Robert ULg; Collin, Frédéric ULg

Conference (2016, May 25)

A 10 m thick loess (aeolian silt) layer located beside the Romont quarry (Eben-Emael, Middle Belgium) has been investigated in order to characterize the mechanical behaviour of the silty material. Cone ... [more ▼]

A 10 m thick loess (aeolian silt) layer located beside the Romont quarry (Eben-Emael, Middle Belgium) has been investigated in order to characterize the mechanical behaviour of the silty material. Cone penetration tests (CPT) have been performed with different cones (M1-type, M2-type and electric) in order to evaluate the influence of the cone on the mechanical behaviour interpretation. Concurrently, laboratory tests have been performed on undisturbed samples from core drillings. Laboratory tests consist of a physical characterization (grain size distribution, Atterberg limits) and a mechanical characterization (oedometer tests). This comprehensive investigation study focuses on the comparison of the loess characterization between in situ and laboratory approaches. CPT-based soil behaviour type charts are analyzed and compared with the Unified Soil Classification System. Many relations also exist in the literature between parameters obtained from CPT results and from laboratory tests. The study explores the existing relations between the cone resistance and the oedometer constrained modulus in order to verify the related coefficients proposed in the literature for silty material. [less ▲]

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See detailÀ la redécouverte d’une série d’autels égyptisants romains
Veymiers, Richard ULg

Conference (2016, May 25)

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See detailLes problématiques de la rénovation du stock bâti dans la ville de demain : résultats d’une étude initiale en Belgique.
Ruellan, Guirec ULg; Attia, Shady ULg

Scientific conference (2016, May 25)

Pour atteindre les objectifs énergétiques de l’Union Européenne pour 2050, et plus largement les objectifs fixés à la dernière COP, le secteur de la construction et de l’habitat doit opérer sa mue vers un ... [more ▼]

Pour atteindre les objectifs énergétiques de l’Union Européenne pour 2050, et plus largement les objectifs fixés à la dernière COP, le secteur de la construction et de l’habitat doit opérer sa mue vers un modèle plus durable. En Belgique, cela passe par la rénovation et l’amélioration des performances du stock bâti existant. La présente étude porte sur l’identification des différents enjeux (environnementaux, économiques et sociaux) liées à la rénovation en Belgique et tente d’objectiver les barrières (de financement, de communication et de réglementation) à une augmentation du taux de rénovation, à travers une revue de littérature des différentes études et projets portant sur ce domaine en Belgique. Ces résultats initiaux devront permettre ultérieurement la conduite des recherches approfondies visant à la modélisation des effets de plusieurs stratégies possibles d’augmentation du taux de rénovation. [less ▲]

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See detailPériurbanisation et efficacité de l'usage de la ressource foncière à Kinshasa
Messina Ndzomo, Jean Pierre ULg; Mate, Jean-Pierre; Halleux, Jean-Marie ULg

Conference (2016, May 25)

Kinshasa est la capitale de la République Démocratique du Congo et la plus grande ville francophone d’Afrique subsaharienne sur le plan démographique et spatial. Alors que Kinshasa comptait 400 000 ... [more ▼]

Kinshasa est la capitale de la République Démocratique du Congo et la plus grande ville francophone d’Afrique subsaharienne sur le plan démographique et spatial. Alors que Kinshasa comptait 400 000 habitants en 1960, son volume de population est actuellement estimé entre 8 et 12 millions d’habitants. La forte croissance démographique de cette ville, dont le taux de progression se situerait autour de 4 % depuis 2000, justifie sa dynamique spatiale. La conséquence immédiate est l’étalement urbain et une urbanisation non maitrisée favorisés par l’accroissement de la demande en logement. La crise du logement est de plus en plus forte dans un contexte marqué par une faiblesse des politiques publiques sur l’habitat. La géographie urbaine de Kinshasa connait, en conséquence, de profondes mutations depuis quelques décennies, des quartiers centraux et péricentraux se densifient et des lotissements périurbains colonisent de vastes territoires. Plus spécifiquement la périurbanisation, phénomène d’étalement des villes, s’y impose très largement. La présente communication porte sur notre projet de thèse qui cherche à comprendre les relations entre les mécanismes fonciers et la production de l’urbanisation à Kinshasa. De manière synthétique, la recherche est basée sur l’hypothèse que l’urbanisation de Kinshasa est spatialement inefficace. Elle est de plus en plus éloignée du centre-ville et des axes principaux et colonise vraisemblablement les zones physiquement inappropriées à l’urbanisation. Il ressort de notre revue de la littérature que l’urbanisation de Kinshasa résulte de dynamiques variées. D’un côté, nous assistons à une très forte densification de certains quartiers. D’un autre côté, la ville connaît un étalement urbain qui s’accompagne du développement de quartiers périphériques à faible densité. La première partie de notre travail vise à quantifier le phénomène d’urbanisation à Kinshasa. Cette quantification sera établie sur base des sources statistiques disponibles. Elle mobilisera également les techniques de la télédétection, afin de suivre l’évolution spatiale de la croissance urbaine. Cette partie du travail permettra notamment de vérifier l’hypothèse consistant à considérer que la croissance de Kinshasa oppose et conjugue des dynamiques de forte densification à des dynamiques d’étalement urbain. C’est cette partie du travail qui devra notamment permettre de vérifier si les logiques d’étalement urbain engendrent un gaspillage de ressources foncières préjudiciables aux activités de l’agriculture (péri) urbaine et au maintien du couvert forestier. La seconde partie de notre travail consistera dans le développement d’enquêtes. Des enquêtes seront menées auprès de deux publics cibles : d’une part, les acteurs actifs dans la production urbaine et, d’autre part, les populations. Enquêter auprès des acteurs de la production urbaine (architectes, promoteurs, planificateurs, chefs traditionnels, administrations : urbanisme, habitat et affaires foncières,…) devra permettre une compréhension des mécanismes fonciers et immobiliers qui alimentent la production du logement à Kinshasa (nous pensons en particulier au rôle des prix et des valeurs sur les phénomènes de densification et d’étalement urbain). En parallèle, enquêter auprès des populations visera à évaluer le niveau d’efficacité spatiale de l’urbanisation mise en place. Développer ce sujet de l’efficacité spatiale consistera à vérifier si, d’un côté, la densification n’atteint pas des niveaux critiques et si, d’un autre côté, l’étalement ne conduit pas à des déplacements – et donc à des coûts de transport – inutiles. [less ▲]

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See detailSemiparametric frailty model for clustered interval-censored data
Cetinyürek, Aysun ULg; Lambert, Philippe ULg

Report (2016)

The shared frailty model is a popular tool to analyze correlated right-censored time-to-event data. In the shared frailty model, the latent frailty is assumed to be shared by the members of a cluster and ... [more ▼]

The shared frailty model is a popular tool to analyze correlated right-censored time-to-event data. In the shared frailty model, the latent frailty is assumed to be shared by the members of a cluster and is assigned a parametric distribution, typically a gamma distribution due to its conjugacy. In the case of interval-censored time-to-event data, the inclusion of frailties results in complicated intractable likelihoods. Here, we propose a exible frailty model for analyzing such data by assuming a smooth semiparametric form for the conditional time-to-event distribution and a parametric or a exible form for the frailty distribution. The results of a simulation study suggest that the estimation of regression parameters is robust to misspeci cation of the frailty distribution (even when the frailty distribution is multimodal or skewed). Given su ciently large sample sizes and number of clusters, the exible approach produces smooth and accurate posterior estimates for the baseline survival function and for the frailty density, and can correctly detect and identify unusual frailty density forms. The methodology is illustrated using dental data from the Signal Tandmobiel® Study. [less ▲]

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See detail33rd International AFFI Conference 2016
Platania, Federico ULg; Lambert, Marie ULg

Scientific conference (2016, May 25)

This paper examines the dynamic trading strategies implemented by hedge fund managers using a Kalman filter of hedge fund betas across styles. We further investigate the risk drivers of dynamic trades ... [more ▼]

This paper examines the dynamic trading strategies implemented by hedge fund managers using a Kalman filter of hedge fund betas across styles. We further investigate the risk drivers of dynamic trades, examining which conditioning/macroeconomic variables strongly lead the time variation in fund trades. We report the significance of macroeconomic factors such as interest rates, dividend yield, GDP growth and US unemployment. We show that hedge fund managers do control the intensity of their exposures according to economic uncertainty and that differences between up- and down-market regimes can be observed. Commonly, Hedge funds tend to dislike high-dividend paying stocks. Besides, all hedge fund styles are shown to display pro-cyclical exposures towards directional equity factors as well as credit and liquidity risks. Small growth stocks, however, are revealed to be crisis investments whose allocation increases with unemployment, inflation or volatility. As volatility increases, the value of growth options embedded into growth stocks indeed increases. Growth stocks are shown to hedge market reversals and volatility. The outperformance of growth companies in recessions might also relate to their cost flexibility. Allocation to small stocks embed strong micro risks and might also constitute a hedge in economic slowdowns. This might explain why some funds with such a particular investment focus appear to be countercyclical. [less ▲]

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See detailKidney-Failure Risk Projection for the Living Kidney-Donor candidate.
DELANAYE, Pierre ULg; Glassock, Richard

in New England Journal of Medicine (2016), 374(21), 2093-2094

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See detailQuel est l'intérêt du test de Pak chez les patients lithiasiques
Castiglione, Vincent ULg; Tostivint, Isabelle; Inaoui et al

Conference given outside the academic context (2016)

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See detailTransplantation hépatique à Liège: 1986-2016
DETRY, Olivier ULg

Scientific conference (2016, May 25)

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See detailAnalyse de la potentialité des outils d’auto-organisation en Wallonie : l'exemple d’un habitat groupé liégeois, les Zurbains
Dethier, Perrine ULg; Halleux, Jean-Marie ULg

Conference (2016, May 25)

La régénération urbaine doit faire face à de nombreux obstacles. Parmi ceux-ci, les plus significatifs sont la réduction des finances publiques ainsi que des obstacles plus structurels comme la captation ... [more ▼]

La régénération urbaine doit faire face à de nombreux obstacles. Parmi ceux-ci, les plus significatifs sont la réduction des finances publiques ainsi que des obstacles plus structurels comme la captation des plus-values foncières pour financer les infrastructures publiques, la coopération entre le secteur public et privé ou la complexité croissante des projets par l’augmentation des acteurs concernés (commune, région, propriétaires fonciers, promoteurs, développeurs, habitants…). Afin de répondre à ce contexte changeant, de nombreuses villes, notamment américaines, anglaises ou néerlandaises, mettent en place des outils d’auto-organisation (‘Buisness improvement district’, ‘tax increment financing’, …) (van der Krabben et Needham, 2008 ; Meerkerk et al., 2013 ; Peyroux et al., 2012 ; Squires et Lord, 2012)1. Dans cette recherche, nous définissions le terme d’auto-organisation comme : « l’émergence et le développement d’initiatives naissant d’un réseau construit en dehors des institutions gouvernementales ou autres et qui peut se rattacher ultérieurement à ces institutions » (Huygen et al., 2012)2. Quatre caractéristiques centrales distinguent le concept d’auto-organisation d’autres formes de participation : les motivations intrinsèques des acteurs, l’organisation par le biais d’un leadership pertinent, l’autonomie vis-à-vis des institutions et la spontanéité et créativité. Alors que dans certains pays, les outils d’auto-organisations deviennent courants, peu d’exemples sont présents en Wallonie. Pourtant, ils pourraient répondre, en partie, aux problèmes de recyclage urbain mis en évidence (Halleux et al. 2004)3. Par le champ de l’économie comportementale, nous étudierons l’exemple d’un habitat groupé liégeois, les Zurbains. « L’économie comportementale est un champ de l’économie qui se fonde sur le comportement des êtres humains observé dans la réalité et/ou en laboratoire afin d’expliquer les choix économiques des acteurs économiques » (Hanne, 2012)4. Ce courant économique remet en cause le concept l’Homo oeconomicus, la représentation théorique du comportement humain en économie néo-classique. Les Zurbains sont un projet d’habitat groupé sur une vaste friche (8 500 m²) située dans un quartier populaire de Liège, Saint-Léonard. En 2005, vingt-six ménages font l’acquisition de ce terrain dans le but d’y réaliser un ensemble de logements basse énergie. Il faudra attendre 9 ans entre l’achat du terrain et l’installation des premiers habitants. Par l’analyse de trois grandes composantes du comportement économique, nous essayerons de comprendre quels ont été les freins au développement du projet et comment les comportements des acteurs ont influencé la réussite du projet. L’analyse portera sur le partage des risques, la confiance entre les acteurs et l’évolution de coopération (inter et extra groupe). Le projet présente de nombreux intérêts à la fois individuels (logement neuf en centre urbain, économie d’échelle) et collectifs (réhabilitation d’une friche, aide financière régionale pour la commune pour l’aménagement des espaces publics alentours). Cependant son développement a été confronté à de nombreux obstacles : la prise de risque prise due au manque d’expertise dans le montage de projet urbain, une rupture de confiance entre les maîtres d’œuvre et le maître d’ouvrage, une collaboration pas toujours évidente entre le privé (les Zurbains) et le public (la ville ou les gestionnaires des impétrants). Sur base de rencontres avec les acteurs, il s’agira dès lors de dégager les forces et les faiblesses des acteurs wallons dans le développement de projet auto-organisé et d’analyser la potentialité de ce type de projet. [less ▲]

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See detailLa distribution par des véhicules électriques
Bay, Maud ULg; Limbourg, Sabine ULg

Scientific conference (2016, May 25)

The objective of vehicle routing problems is to design a set of efficient vehicle routes to provide goods from a depot to a set of customers satisfying specific constraints. Classical variants of these ... [more ▼]

The objective of vehicle routing problems is to design a set of efficient vehicle routes to provide goods from a depot to a set of customers satisfying specific constraints. Classical variants of these problems consider that routes are performed by internal combustion engine vehicles. These vehicles have a long and easy-to-restore driving range. However, due to the short driving range, long battery recharging times and the limited availability of charging infrastructure, routing algorithms for EV need to be developped. Maximizing the driving range of the vehicle leads to an examination of the main factors in energy consumption which are: the mass of the vehicle and its payload, engine efficiency, vehicle speed, the drive pattern, road grade, and vehicle recharge ability while driving. Results from this research will provide an optimal management of urban logistics where night delivery, through the use of those silent vehicles, remains one of the main benefits. [less ▲]

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See detailL'effet de l'écrouissage rotationnel sur le comportement des sols argileux
Ahayan, Sanae ULg; Yin, Zhen-Yu; Kotronis, Panagiotis et al

Conference (2016, May 25)

Induced anisotropy is a constitutive feature of clays that can be introduced through a proper "Rotational hardening law" allowing the rotation of the yield and the potential plastic surfaces in the stress ... [more ▼]

Induced anisotropy is a constitutive feature of clays that can be introduced through a proper "Rotational hardening law" allowing the rotation of the yield and the potential plastic surfaces in the stress space. Two rotational hardening laws are studied in this paper. Validation is provided using the results of a drained triaxial test of a Finnish clay. Finite Elements simulations of a circular rigid footing considering an isotropic and anisotropic constitutive laws are presented. The objective is firstly to identify the influence of the isotropy assumption in geotechnical design and secondly to study the effect of different hardening laws on the foundation behavior. [less ▲]

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See detailDenCity: Zero Energy Light Weight Construction Households for Urban Densification
Amer, Mohamed ULg; Attia, Shady ULg

in Rencontres Universitaires de Génie Civil de l'AUGC (2016, May 25)

This paper is a part of an ongoing research in the field of sustainable urban densification through providing innovative solutions for zero energy light weight construction. The focus aim of this research ... [more ▼]

This paper is a part of an ongoing research in the field of sustainable urban densification through providing innovative solutions for zero energy light weight construction. The focus aim of this research is to identify the gaps in the construction solutions for roof stacking, to feed in the innovation pipeline of the European construction landscape in the coming years. This paper presents a comprehensive review of different case studies and efforts in the field of roof raising and its repetition potentials. Based on a structured review, 8 different cases from three different European countries were sorted, placing a variety of methods in comparison with each other. The main contribution of this review lies in the analyses of the existing information in this field and the classification of the different validated methods and approaches that has been used. Finally, despite the existing challenges, it was found that the concept of roof stacking can be widely spread and applied in different contexts. Future research is going to investigate possible solution and to formulate structured scientific approaches to widen its application. [less ▲]

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See detailHow to improve the valorisationprocess of End-Of-Life vehicles? LCA as a tool to help decision
Belboom, Sandra ULg; Lewis, Grégory; Bareel, Pierre-François et al

Conference (2016, May 24)

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See detailComportement des structures soumises au feu
Gernay, Thomas ULg

Learning material (2016)

Les incendies représentent une sollicitation importante pouvant agir sur les bâtiments et autres structures du génie civil. Ce cours vise à donner un aperçu de la problématique du feu vis-à-vis des ... [more ▼]

Les incendies représentent une sollicitation importante pouvant agir sur les bâtiments et autres structures du génie civil. Ce cours vise à donner un aperçu de la problématique du feu vis-à-vis des structures et de la manière dont on peut concevoir ces dernières afin qu’elles assurent la sécurité des biens et des personnes en cas d’incendie. Les thèmes abordés couvriront la description des actions thermiques liées au développement d’un incendie et le comportement thermique et mécanique des matériaux à haute température. Les différents moyens de conception anti feu seront présentés ainsi que les méthodes de calcul pouvant mener à un dimensionnement viable face à cette sollicitation exceptionnelle. Finalement, le cours présentera des développements récents en ingénierie de la sécurité incendie et leur implémentation dans des projets réels de grande envergure. [less ▲]

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