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See detailMassivement histologique : entre continuité et (r)évolution pédagogique. Lancement du premier Massive Open Online Course (MOOC) sur des travaux pratiques en Histologie à destination de nos étudiants mais aussi du grand public.
Multon, Sylvie ULg; Pesesse, Laurence ULg; Weatherspoon, Alodie ULg et al

Poster (2017, March)

L’acronyme anglophone MOOC désigne les « Massive Open Online Courses » que l’on pourrait traduire par « formation en ligne massive ouverte à tous ». Nés aux États-Unis avec un programme sur l’intelligence ... [more ▼]

L’acronyme anglophone MOOC désigne les « Massive Open Online Courses » que l’on pourrait traduire par « formation en ligne massive ouverte à tous ». Nés aux États-Unis avec un programme sur l’intelligence artificielle dispensé par l’université de Stanford, ces cours en ligne accessibles gratuitement font miroiter la possibilité d’une démocratisation maximale des savoirs. A ce titre, les MOOC bénéficient des innovations issues du Web 2.0 : ils tirent le meilleur de la rencontre entre les nouveaux usages induits par les réseaux sociaux et les apports de la pédagogique active. Ces cinq dernières années, nous avons dispensé les travaux pratiques en Histologie aux premières années d’étude de la faculté de Médecine de l’Université de Liège par une méthodologie hybride alliant les bénéfices d’un enseignement à distance et ceux de séances menées en face-à-face (Multon et al., 2015). Notre dispositif d’auto-apprentissage invite chaque année plus de 500 étudiants à parcourir plusieurs coupes d’organes digitalisées afin de découvrir les structures histologiques pointées par des balises interactives pour chaque grande famille de tissus. La mise en ligne d’un MOOC dédié aux travaux pratiques d’Histologie s’inscrit dans une suite logique de nos activités avec une volonté de donner accès à nos ressources numériques à un public plus large. « Découvrir les tissus fondamentaux du corps humain en explorant par vous même des lames histologiques au microscope », tel est le programme de notre MOOC intitulé « Introduction à l’histologie, exploration des tissus du corps humain ». Celui-ci a débuté en février 2017 et est hébergé sur la plate-forme FUN encadrée par le ministère de l’Enseignement supérieur et de la Recherche du ministère français (https://www.fun-mooc.fr/courses/ulg/108001/session01/about). Ce MOOC s’adresse à un public large : aux étudiants ou futurs étudiants dans le domaine médical, paramédical ou scientifique, aux enseignants, chercheurs, professionnels dans le secteur de la santé, décideurs dans le domaine de l’éducation ou de la santé ou simplement aux curieux désireux de comprendre à partir de quoi le corps humain est construit. Deux parcours pédagogiques permettant d’approfondir différemment la matière sont proposés pour correspondre au mieux aux objectifs ou motivations de chacun. Au travers de vidéos explicatives contenant des dessins réalisés sous vos yeux et des liens avec l’anatomie suivie d’activités interactives telles que la manipulation d’un microscope virtuel, de nombreux quiz et d’activités réalisées avec les pairs, les participants seront capables de reconnaître les différents types de cellules et tous les éléments qui les entourent afin de comprendre comment ils s’organisent entre eux pour former des tissus aux fonctions spécifiques. Une recherche est actuellement en cours sur l’étude des traces d’activités des participants au MOOC en fonction du parcours pédagogique choisi afin d’évaluer notamment l’impact des différentes composantes de l’expérience d’apprentissage. [less ▲]

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See detailEU competition law
Van Cleynenbreugel, Pieter ULg

in Ugirashebuja, Emmanuel; Ruhangisa, John Eures; Ottervanger, Tom (Eds.) et al East African Community Law: institutional, substantive and comparative EU aspects (2017)

This chapter provides an overview of the principles of EU competition law, its relationship to EU internal market law and the similarities and differences between this body of law and East African ... [more ▼]

This chapter provides an overview of the principles of EU competition law, its relationship to EU internal market law and the similarities and differences between this body of law and East African competition law. [less ▲]

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See detailEnglish translation and validation of the SarQoL®, a quality of life questionnaire specific for sarcopenia
Beaudart, Charlotte ULg; Edwards, Mark; Moss, Charlotte et al

in Age & Ageing (2017), 46(2), 271-7

Background: the first quality of life questionnaire specific to sarcopenia, the SarQoL®, has recently been developed and validated in French. To extend the availability and utilisation of this ... [more ▼]

Background: the first quality of life questionnaire specific to sarcopenia, the SarQoL®, has recently been developed and validated in French. To extend the availability and utilisation of this questionnaire, its translation and validation in other languages is necessary. Objective: the purpose of this study was therefore to translate the SarQoL® into English and validate the psychometric properties of this new version. Design: cross-sectional. Setting: Hertfordshire, UK. Subjects: in total, 404 participants of the Hertfordshire Cohort Study, UK. Methods: the translation part was articulated in five stages: (i) two initial translations from French to English; (ii) synthesis of the two translations; (iii) backward translations; (iv) expert committee to compare the backward translations with the original questionnaire and (v) pre-test. To validate the English SarQoL®, we assessed its validity (discriminative power, construct validity), reliability (internal consistency, test–retest reliability) and floor/ceiling effects. Results: the SarQoL® questionnaire was translated without any major difficulties. Results indicated a good discriminative power (lower score of quality of life for sarcopenic subjects, P = 0.01), high internal consistency (Cronbach’s alpha of 0.88), consistent construct validity (high correlations found with domains related to mobility, usual activities, vitality, physical function and low correlations with domains related to anxiety, self-care, mental health and social problems) and excellent test–retest reliability (intraclass coefficient correlation of 0.95, 95%CI 0.92–0.97). Moreover, no floor/ceiling has been found. Conclusions: a valid SarQoL® English questionnaire is now available and can be used with confidence to better assess the disease burden associated with sarcopenia. It could also be used as a treatment outcome indicator in research. [less ▲]

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See detailLocal Identification of Voltage Instability from Load Tap Changer Response
Weckesser, Johannes ULg; Papangelis, Lampros ULg; Vournas, Costas et al

in Sustainable Energy, Grids and Networks (2017)

This paper presents a local long-term voltage instability monitoring method, which is suitable for on-line applications. The proposed extended-time Local Identification of Voltage Emergency Situations ... [more ▼]

This paper presents a local long-term voltage instability monitoring method, which is suitable for on-line applications. The proposed extended-time Local Identification of Voltage Emergency Situations (eLIVES) method is a significantly modified version of the previously presented LIVES method. The new method is not bound to assessing system response over a predefined LTC tapping period. This allows handling LTCs with variable delays, as well as events taking place during the tapping sequence impacting the distribution voltages. For that purpose, eLIVES applies recursive least square fitting to acquired distribution voltage measurements and a new set of rules to detect a voltage emergency situation. The effectiveness of the eLIVES method is presented on the IEEE Nordic test system for voltage stability and security assessment. [less ▲]

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See detailLa défaillance du consommateur
Renson, Florence ULg; Biquet, Christine ULg

in Biquet, Christine; Beguin, Etienne (Eds.) Le crédit hypothécaire au consommateur. Etat de la question. (2017)

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See detailDifferentiation of patented crystalline glucosamine sulfate from other glucosamine preparations will optimize osteoarthritis treatment.
Saengnipanthkul, Sukit; Waikakul, Saranatra; Rojanasthien, Sattaya et al

in International Journal of Rheumatic Diseases (2017)

Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and ... [more ▼]

Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and delay joint structural changes. Among SYSADOAs, evidence is greatest for the patented crystalline glucosamine sulfate (pCGS) formulation (Mylan). Glucosamine is widely available as glucosamine sulfate (GS) and glucosamine hydrochloride (GH) preparations that vary substantially in molecular form, pharmaceutical formulation and dose regimen. Only pCGS is given as a highly bioavailable once-daily dose (1500 mg), which consistently delivers the plasma levels of around 10 mumol/L required to inhibit interleukin-1-induced expression of genes involved in the pathophysiology of joint inflammation and tissue destruction. Careful consideration of the evidence base reveals that only pCGS reliably provides a moderate effect size on pain that is higher than paracetamol and equivalent to non-steroidal anti-inflammatory drugs (NSAIDs), while non-crystalline GS and GH fail to reach statistical significance for pain reduction. Chronic administration of pCGS has disease-modifying effects, with a reduction in need for total joint replacement lasting for 5 years after treatment cessation. Pharmacoeconomic studies of pCGS demonstrate long-term reduction in additional pain analgesia and NSAIDs, with a 50% reduction in costs of other OA medication and healthcare consultations. Consequently, pCGS is the logical choice, with demonstrated medium-term control of pain and lasting impact on disease progression. Physician and patient education on the differentiation of pCGS from other glucosamine formulations will help to improve treatment selection, increase treatment adherence, and optimize clinical benefit in OA. [less ▲]

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See detailOsteoporosis in Frail Patients: A Consensus Paper of the Belgian Bone Club.
Gielen, E.; Bergmann, P.; Bruyère, Olivier ULg et al

in Calcified Tissue International (2017)

In this consensus paper, the Belgian Bone Club aims to provide a state of the art on the epidemiology, diagnosis, and management of osteoporosis in frail individuals, including patients with anorexia ... [more ▼]

In this consensus paper, the Belgian Bone Club aims to provide a state of the art on the epidemiology, diagnosis, and management of osteoporosis in frail individuals, including patients with anorexia nervosa, patients on dialysis, cancer patients, persons with sarcopenia, and the oldest old. All these conditions may indeed induce bone loss that is superimposed on physiological bone loss and often remains under-recognized and under-treated. This is of particular concern because of the major burden of osteoporotic fractures in terms of morbidity, mortality, and economic cost. Therefore, there is an urgent need to appreciate bone loss associated with these conditions, as this may improve diagnosis and management of bone loss and fracture risk in clinical practice. [less ▲]

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See detailMultidisciplinary rehabilitation program after breast cancer: benefits on physical function, anthropometry and quality of life.
Leclerc, Anne-France ULg; Foidart-Dessalle, Marguerite ULg; Tomasella, Marco ULg et al

in European Journal of Physical and Rehabilitation Medicine (2017)

BACKGROUND: Different clinical trials show beneficial effects of physical training offered during and / or after breast cancer treatment. However, given the variety of side effects that may be encountered ... [more ▼]

BACKGROUND: Different clinical trials show beneficial effects of physical training offered during and / or after breast cancer treatment. However, given the variety of side effects that may be encountered, physical training could be combined with psychological, relational and social guidance. This kind of multidisciplinary program has been little studied so far. AIM: To determine the benefits of a three-month multidisciplinary rehabilitation program among women after breast cancer treatment. DESIGN: Controlled no-randomized trial. SETTING: University for outcomes, University Hospital Center for interventions. POPULATION: Two hundred and nine outpatients who have been treated for a primary breast carcinoma. METHODS: Patients were divided into a control group (n=106) and an experimental group (n=103) which has benefited from a rehabilitation program of three months including physical training and psycho-educational sessions. The assessments, performed before and after the program, included functional assessments ("Sit and Reach Test", maximal incremental exercise test and "Six-Minute Walk Test"), body composition measurements (body mass index (BMI) and body fat percentage) and a questionnaire (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30). RESULTS: After three months, flexibility, walking distance and all parameters measured during the maximal incremental exercise, except maximal heart rate, were significantly improved in the experimental group. The body fat percentage was significantly decreased and a significant improvement was observed for perceived health status (quality of life), functional role, emotional state, physical, cognitive and social functions and for most symptoms. In the control group, most of these improvements didn't appear and a significant increase in BMI and body fat percentage was observed. CONCLUSIONS: This trial identifies the benefits of a well detailed multidisciplinary rehabilitation program, including physical re-conditioning and psycho-educational sessions, with important improvements in functional capacity, body composition and the majority of functions and symptoms among women after breast cancer treatment. CLINICAL REHABILITATION IMPACT: Through its results, this study could contribute to the development of hospital quality standards for oncologic rehabilitation. Physiotherapists can efficiently propose this kind of multidisciplinary rehabilitation program. [less ▲]

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See detailNutrition and physical activity in the prevention and treatment of sarcopenia: systematic review.
Beaudart, Charlotte ULg; Dawson, A.; Shaw, S. C. et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2017)

This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise ... [more ▼]

This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise has a positive impact on muscle mass and muscle function in subjects aged 65 years and older. However, any interactive effect of dietary supplementation appears to be limited. INTRODUCTION: In 2013, Denison et al. conducted a systematic review including 17 randomized controlled trials (RCTs) to explore the effect of combined exercise and nutrition intervention to improve muscle mass, muscle strength, or physical performance in older people. They concluded that further studies were needed to provide evidence upon which public health and clinical recommendations could be based. The purpose of the present work was to update the prior systematic review and include studies published up to October 2015. METHODS: Using the electronic databases MEDLINE and EMBASE, we identified RCTs which assessed the combined effect of exercise training and nutritional supplementation on muscle strength, muscle mass, or physical performance in subjects aged 60 years and over. Study selection and data extraction were performed by two independent reviewers. RESULTS: The search strategy identified 21 additional RCTs giving a total of 37 RCTs. Studies were heterogeneous in terms of protocols for physical exercise and dietary supplementation (proteins, essential amino acids, creatine, beta-hydroxy-beta-methylbuthyrate, vitamin D, multi-nutrients, or other). In 79% of the studies (27/34 RCTs), muscle mass increased with exercise but an additional effect of nutrition was only found in 8 RCTs (23.5%). Muscle strength increased in 82.8% of the studies (29/35 RCTs) following exercise intervention, and dietary supplementation showed additional benefits in only a small number of studies (8/35 RCTS, 22.8%). Finally, the majority of studies showed an increase of physical performance following exercise intervention (26/28 RCTs, 92.8%) but interaction with nutrition supplementation was only found in 14.3% of these studies (4/28 RCTs). CONCLUSION: Physical exercise has a positive impact on muscle mass and muscle function in healthy subjects aged 60 years and older. The biggest effect of exercise intervention, of any type, has been seen on physical performance (gait speed, chair rising test, balance, SPPB test, etc.). We observed huge variations in regard to the dietary supplementation protocols. Based on the included studies, mainly performed on well-nourished subjects, the interactive effect of dietary supplementation on muscle function appears limited. [less ▲]

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See detailMicro-mechanical testing of magnesium based composites reinforced by carbon fibers manufactured by friction stir processing
Simar, Aude; Ryelandt, Sophie; Delannay, Francis et al

Conference (2017, February 28)

Short C fibres–Mg matrix (AZ91D) composites have been produced by friction stir processing sandwiches made of a layer of C fabric stacked between two sheets of Mg alloy. The process parameters have been ... [more ▼]

Short C fibres–Mg matrix (AZ91D) composites have been produced by friction stir processing sandwiches made of a layer of C fabric stacked between two sheets of Mg alloy. The process parameters have been optimized to ensure a good fiber distribution. 3D X-ray tomography reveals that the fibers orient like onion rings. Thermal treatments have allowed to modify the flow stress level of the matrix material. Tensile testing inside the scanning electron microscope have revealed the decohesion at the fiber/matrix interface if the fibers are preferentially oriented perpendicularly to the loading direction. Modelling allows to estimate the stress needed to initiate this decohesion is about 250 MPa, i.e. appearing early in heat treated samples. To compare with different loading conditions, micro-compression and instrumented micro-indentation testing have also been performed. The consequence of the loading path on the decohesion is discussed. [less ▲]

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See detailOptimized integration of heat storage into district heating networks fed by a biomass CHP plant.
Sartor, Kevin ULg

in Proceedings (2017, February 28)

Biomass Combined Heat and Power (CHP) plants connected to district heating networks (DHN) are recognized as a very good opportunity to increase the share of renewable sources into energy systems. However ... [more ▼]

Biomass Combined Heat and Power (CHP) plants connected to district heating networks (DHN) are recognized as a very good opportunity to increase the share of renewable sources into energy systems. However, as CHP plants are not optimized for electricity production, their operation is profitable only if a sufficient heat demand is available throughout the year. On the other hand, these plants often work for baseline operation and back-up boilers are used to supply the peak demand. To extend the use of the CHP plants and reduce costs, conventional fuel use and emissions, it is proposed to study the feasibility of using additional high temperature heat storage as retrofit of an existing CHP plant. This work is based on a simple and effective methodology that provides accurate estimations of economic, environmental and energetic performances of CHP plants connected to district heating networks. The DHN of the University in Liège (Belgium) is used as an application framework to demonstrate the effectiveness of the selected approach. The potential energy and pollutant emissions savings and resulting energy costs are estimated and the current policy limitations will be discussed. [less ▲]

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See detailShort-Term Local Adaptation of Historical Common Bean (Phaseolus vulgaris L.) Varieties and Implications for In Situ Management of Bean Diversity
Klaedtke, Stephanie ULg; Caproni, Leonardo; Klauck, Julia et al

in International Journal of Molecular Sciences (2017), 18

Recognizing both the stakes of traditional European common bean diversity and the role farmers’ and gardeners’ networks play in maintaining this diversity, the present study examines the role that local ... [more ▼]

Recognizing both the stakes of traditional European common bean diversity and the role farmers’ and gardeners’ networks play in maintaining this diversity, the present study examines the role that local adaptation plays for the management of common bean diversity in situ. To the purpose, four historical bean varieties and one modern control were multiplied on two organic farms for three growing seasons. The fifteen resulting populations, the initial ones and two populations of each variety obtained after the three years of multiplication, were then grown in a common garden. Twenty-two Simple Sequence Repeat (SSR) markers and 13 phenotypic traits were assessed. In total, 68.2% of tested markers were polymorphic and a total of 66 different alleles were identified. FST analysis showed that the genetic composition of two varieties multiplied in different environments changed. At the phenotypic level, differences were observed in flowering date and leaf length. Results indicate that three years of multiplication suffice for local adaptation to occur. The spatial dynamics of genetic and phenotypic bean diversity imply that the maintenance of diversity should be considered at the scale of the network, rather than individual farms and gardens. The microevolution of bean populations within networks of gardens and farms emerges as a research perspective. [less ▲]

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See detailLiens entre mathématiques et jeux
Bair, Jacques ULg

E-print/Working paper (2017)

Le présent travail se compose de plusieurs parties. En premier lieu, nous définissons le concept général de jeu et présentons quelques mathématiciens célèbres, de toutes époques, qui étaient (ou sont ... [more ▼]

Le présent travail se compose de plusieurs parties. En premier lieu, nous définissons le concept général de jeu et présentons quelques mathématiciens célèbres, de toutes époques, qui étaient (ou sont encore) des adeptes de jeux mathématiques. Ensuite, nous établissons une typologie des jeux mathématiques. Une deuxième partie est consacrée à l’intervention des jeux dans l’enseignement des mathématiques. Nous donnons divers avantages des activités ludiques en classe, mais également des objections relatives à leur usage à des fins pédagogiques. Nous nous demandons aussi comment sélectionner un jeu pour des élèves et exhibons des exemples concrets de jeux exploitables en classe. Ce travail se termine par une bibliographie sur le sujet, ainsi que par une annexe composée de diapositives présentées lors d’un exposé réalisé à l’Université du Luxembourg dans le cadre de la Formation Pédagogique (FOPED) : nous y décrivons brièvement différentes épreuves ludiques proposées ces dernières années à des élèves de l’enseignement secondaire en France, Belgique et au Luxembourg. [less ▲]

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See detailRevisiting global fossil fuel and biofuel emissions of ethane
Tzompa-Sosa, Z. A.; Mahieu, Emmanuel ULg; Franco, Bruno ULg et al

in Journal of Geophysical Research. Atmospheres (2017), 122(4), 2493--2512

Recent measurements over the Northern Hemisphere indicate that the long-term decline in the atmospheric burden of ethane (C2H6) has ended and the abundance increased dramatically between 2010 and 2014 ... [more ▼]

Recent measurements over the Northern Hemisphere indicate that the long-term decline in the atmospheric burden of ethane (C2H6) has ended and the abundance increased dramatically between 2010 and 2014. The rise in C2H6 atmospheric abundances has been attributed to oil and natural gas extraction in North America. Existing global C2H6 emission inventories are based on outdated activity maps that do not account for current oil and natural gas exploitation regions. We present an updated global C2H6 emission inventory based on 2010 satellite-derived CH4 fluxes with adjusted C2H6 emissions over the U.S. from the National Emission Inventory (NEI 2011). We contrast our global 2010 C2H6 emission inventory with one developed for 2001. The C2H6 difference between global anthropogenic emissions is subtle (7.9 versus 7.2 Tg yr−1), but the spatial distribution of the emissions is distinct. In the 2010 C2H6 inventory, fossil fuel sources in the Northern Hemisphere represent half of global C2H6 emissions and 95% of global fossil fuel emissions. Over the U.S., unadjusted NEI 2011 C2H6 emissions produce mixing ratios that are 14–50% of those observed by aircraft observations (2008–2014). When the NEI 2011 C2H6 emission totals are scaled by a factor of 1.4, the Goddard Earth Observing System Chem model largely reproduces a regional suite of observations, with the exception of the central U.S., where it continues to underpredict observed mixing ratios in the lower troposphere. We estimate monthly mean contributions of fossil fuel C2H6 emissions to ozone and peroxyacetyl nitrate surface mixing ratios over North America of ~1% and ~8%, respectively. [less ▲]

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See detailCarbon dioxide evasion from the Seine River: Drivers analysis and spatiotemporal reconstruction
Marescaux, A; Thieu, v; Borges, Alberto ULg et al

Conference (2017, February 26)

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See detailThermal comfort models for net zero energy buildings in hot climates
Belkhouane, Hamza ULg; Hensen, Jan; Attia, Shady ULg

in Second International Conference on Energy and Indoor Environment for Hot Climates (2017, February 26)

Several energy efficiency concepts and comfort models emerged in the last 15 years seeking high performance buildings and optimal occupant comfort conditions. The aim of high performance buildings is to ... [more ▼]

Several energy efficiency concepts and comfort models emerged in the last 15 years seeking high performance buildings and optimal occupant comfort conditions. The aim of high performance buildings is to reduce the carbon footprint and energy consumption of buildings while maintain a fit to purpose comfort. In this context, this work raises the question of fir to purpose comfort models that can from one side reduce the energy consumption of typical office buildings in hot climates (cooling dominated) while on the other side ensuring indoor thermal comfort. Indeed, studies that address energy efficiency are many, however it is in most cases applied to temperate or cold climates and barely explored for hot climates. The objective of this paper is to (1) combine several comfort models for a net zero energy building in hot climates, (2) select the comfort model that shows the optimal comfort quality of indoor environment and (3) compare the building's annual energy consumption for each used comfort model. To respond to our research problems, a methodology has been established, which goes through several phases. First identifying the different comfort models comfortable to use in hot climates (ISO 7730 / EN 15251 / adaptive ASHRAE / Givoni), secondly selecting a typical validated office building model as a reference building and finally selecting representative cities in the Mediterranean arid and hot climate (Algiers / Sicily / Cairo / Dubai). The study used building performance simulation to generate the different results on the energy consumption and the operative temperatures of the different models of comfort in each city. The paper ultimately identifies the fit to purpose comfort models for a medium size net zero energy office building in hot climates. The paper presents a comparison that can help building professional to identify the most appropriate comfort model that allows optimizing energy consumption, ensuring thermal comfort for robust perfromnce of net zero energy buildings in hot climates. [less ▲]

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See detailI Am Very Sorry Sir! Breaking Bad News to Customers
Delcourt, Cécile ULg; Gremler, Dwayne; Greer, Dominique

Scientific conference (2017, February 25)

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See detailGenscript meeting invited by GIGA viral vector platform
Golestan Hashemi, Farahnaz Sadat ULg

Learning material (2017)

Detailed reference viewed: 23 (2 ULg)