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See detailEnergy assessment of suburban neighborhoods : insights from Wallonia and perspectives for a suburban renewal
Marique, Anne-Françoise ULg

Conference (2017, April 12)

The aim of the paper is to present a method to assess the energy efficiency of suburban areas, taking into account both energy efficiency of buildings and the impacts of location and urban form on the ... [more ▼]

The aim of the paper is to present a method to assess the energy efficiency of suburban areas, taking into account both energy efficiency of buildings and the impacts of location and urban form on the energy balance of suburban areas. The method is applied to the Walloon region of Belgium and perspectives for a sustainable suburban renewal are proposed. [less ▲]

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See detailDocking and molecular dynamics simulations of the Fyn-SH3 domain with free and phospholipid bilayer-associated 18.5-kDa myelin basic protein (MBP) – Insights into a non-canonical and fuzzy interaction
Bessonov, Kyrylo ULg; Harauz, George; Vassall, Kenrick

in Proteins (2017)

The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence ... [more ▼]

The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence numbering), were studied in silico via docking and molecular dynamics over 50-ns trajectories. The results show that interaction between the two proteins is energetically favorable and heavily-dependent on the MBP proline-rich region (P93-P98) in both aqueous and membrane environments. In aqueous conditions, the xα2-peptide/Fyn-SH3 complex adopts a “sandwich”-like structure. In the membrane context, the xα2-peptide interacts with the Fyn-SH3 domain via the proline-rich region and the β-sheets of Fyn-SH3, with the latter wrapping around the proline-rich region in a form of a clip. Moreover, the simulations corroborate prior experimental evidence of the importance of upstream segments beyond the canonical SH3-ligand. This study thus provides a more-detailed glimpse into the context-dependent interaction dynamics and importance of the β-sheets in Fyn-SH3 and proline-rich region of MBP. [less ▲]

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See detailAzacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects
Ehx, Grégory ULg; Fransolet, Gilles ULg; De Leval, Laurence et al

in Oncoimmunology (2017)

The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading ... [more ▼]

The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Treg). Here, we investigated the impact of AZA on xenogeneic graft-versus-host disease (xGVHD) and graft-versus-leukemia effects in a humanized murine model of transplantation (human PBMCs-infused NSG mice), and described the impact of the drug on human T cells in vivo. We observed that AZA improved both survival and xGVHD scores. Further, AZA significantly decreased human T-cell proliferation as well as IFN-γ and TNF-α serum levels, and reduced the expression of GRANZYME B and PERFORIN 1 by cytotoxic T cells. In addition, AZA significantly increased Treg frequency through hypomethylation of FOXP3i1 as well as increased Treg proliferation. The later was subsequent to higher STAT5 signaling in Treg from AZA-treated mice, which resulted from higher IL-2 secretion by conventional T cells from AZA-treated mice itself secondary to demethylation of the IL-2 gene promoter by AZA. Importantly, Tregs harvested from AZA-treated mice were suppressive and stable over time since they persisted at high frequency in secondary transplant experiments. Finally, graft-versus-leukemia effects (assessed by growth inhibition of THP-1 cells, transfected to express the luciferase gene) were not abrogated by AZA. In summary, our data demonstrate that AZA prevents xGVHD without abrogating graft-versus-leukemia effects. These findings could serve of basis for further studies of GVHD prevention by AZA in acute myeloid leukemia patients offered an allogeneic transplantation. [less ▲]

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See detailParacervix Parametrium
Bonnet, Pierre ULg

Scientific conference (2017, April 11)

Detailed reference viewed: 10 (0 ULg)
See detailQuaternary prevention library and resources (QP library)
Pizzanelli, Miguel; Lavalle, Ricardo; Jamoulle, Marc ULg

Learning material (2017)

Collaborative Database on Quaternary Prevention Resources and References. Base de datos colaborativa de recursos y referencias bibliográficas sobre Prevención Cuaternaria. Base de Dados Colaborativa de ... [more ▼]

Collaborative Database on Quaternary Prevention Resources and References. Base de datos colaborativa de recursos y referencias bibliográficas sobre Prevención Cuaternaria. Base de Dados Colaborativa de Recursos e Referências sobre Prevenção Quaternária. Réseau collaboratif de ressources et de références en matière de Prévention du Quaternaire [less ▲]

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See detailPelvic anatomy, a constructive approach
Bonnet, Pierre ULg

Scientific conference (2017, April 10)

Detailed reference viewed: 12 (1 ULg)
See detailPelvic ureter
Bonnet, Pierre ULg

Scientific conference (2017, April 10)

Detailed reference viewed: 8 (1 ULg)
See detailTopographic anatomy of the pelvic vessels
Bonnet, Pierre ULg

Scientific conference (2017, April 10)

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See detailTowards Knowledge management in General Practice & Family Medicine; Guide to the indexing of master thesis.
Jamoulle, Marc ULg

Learning material (2017)

The Francophone Coordination Center for Training in General Practice (CCFFMG) (www.ccffmg.be)(French) is in charge of organizing the public release of the End-of-Study works (Master thesis) in General ... [more ▼]

The Francophone Coordination Center for Training in General Practice (CCFFMG) (www.ccffmg.be)(French) is in charge of organizing the public release of the End-of-Study works (Master thesis) in General Practice/Family Medicine (GP/FM) . This work is carried out at the end of the Master of Specialty of the Departments of General Practice of the Free University of Brussels (ULB), the Catholic University of Louvain (UCL) and the University of Liège (ULg). A dedicated website (www.mgtfe.be) offers an online copywriting guide. This site provides also a description and instruction manual for a GP/FM indexing system discussed in this document. This experimental system, based on the assembly of the International Classification of Primary Care, second version (ICPC-2), and a new contextual classification called Q-Codes version 2.5 is intended to help the manual indexation of the Master Thesis. The package, called Core Content Classification in GP/FM (3CGP), is now available in 8 languages (en-fr-nl-es-pt-vi-ko-tr) on the multilingual web site of Department of Medical Information and Medical Informatics (B2IM) of the University of Rouen (www.hetop.eu/q) together with a companion site (http://3cgp.woncaeurope.org) (in English). Family physician will be asked to choose a number of proposed codes to index their jobs at the time of online filing. The publishing site will be equipped with a search module based on the 3CGP indexing system. An evaluation of the system of indexing by the users is organized. [less ▲]

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See detailRevista "Esfera pública discursiva"
Becerra Mayor, David ULg

in Esfera pública discursiva (2017), 1

Número 1 de la revista de crítica e información literaria realizada por las y los estudiantes de "Stylistique et critique de l’espagnol moderne" del curso 2016-2017, de la Université de Liège.

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See detailLe sens de la vue et le sens de la marche. Déambulation et signification dans l'œuvre de Marc-Antoine Mathieu
Belloi, Livio ULg

Conference (2017, April 08)

Dans la foulée de l'ouvrage publié par Ian Hague ("Comics and the Senses", Routledge, 2014), cette conférence aborde la double question du sens et des sens dans le domaine de la bande dessinée ... [more ▼]

Dans la foulée de l'ouvrage publié par Ian Hague ("Comics and the Senses", Routledge, 2014), cette conférence aborde la double question du sens et des sens dans le domaine de la bande dessinée contemporaine, en se concentrant d'abord sur l'œuvre de Marc-Antoine Mathieu. Chemin faisant, l'œuvre de Mathieu se voit mise en regard avec "La Différence invisible" (2016) de Julie Dachez et Mademoiselle Caroline. [less ▲]

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See detailL'excuse est devenue une arme en politique
Grandjean, Geoffrey ULg

Article for general public (2017)

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See detailEffects of various design parameters on system-level fire fragility functions for steel buildings
Elhami Khorasani, Negar; Gernay, Thomas ULg; Garlock, Maria

Conference (2017, April 07)

The existing literature in fire engineering is mostly based on single component study of structures, as opposed to system level building performance. In current practice, fire does not need to be ... [more ▼]

The existing literature in fire engineering is mostly based on single component study of structures, as opposed to system level building performance. In current practice, fire does not need to be considered as part of the structural design of the building. The required fire protection for steel components in a building is based on prescriptive design guidelines, which are based on standard fire tests on individual structural members. In addition, the fire-structure engineering has primary focused on deterministic analysis, while the field is moving towards performance-based design in recent years. Meanwhile, the scenarios leading to a fire event and the performance of the structure at elevated temperatures involve a great level of uncertainty. This work focuses on fire-structure interaction with the objective of developing fire fragility functions that capture fire damage uncertainty for the entire building (i.e., at the system-level). A fragility function provides the probability of exceeding a damage state for a given intensity measure of a given hazard. Fire fragility functions can be developed to measure the expected losses based on performance of a building structural system, rather than a single component. Different functions can be developed for buildings with different typologies (e.g. high-rise steel building with moment resisting frame, low rise steel building with bracing). This presentation derives fragility functions based on stochastic analyses of prototype buildings. In developing the fragility functions, uncertainties in the fire model, the heat transfer model and the thermo-mechanical response should be considered; but such a large number of random variables adds to the complexity of analysis and the computational time. Based on a sensitivity analysis for steel gravity frames, this work identifies the most important input parameters to be considered as random variables when developing fire fragility functions for an entire building. The sensitivity analysis for a multi-story steel building prototype is completed considering uncertainties at the compartment and building levels. At the compartment level, uncertainty in the fire scenario, compartment geometry, applied load, thermal and mechanical properties of steel and insulating materials are considered. At the building level, the influence of fire-resistance rating, building height, and occupancy type are studied. The results of this study identify the local and global parameters needed as part of deriving system-level fire fragility functions for a steel building. [less ▲]

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See detailComputerized adaptive testing: Principles, issues and implementation
Magis, David ULg

Scientific conference (2017, April 07)

Computerized adaptive testing (CAT) has become an important field of research for educational and psychological measurement. It provides tailored testing at the test taker level, focusing on the optimal ... [more ▼]

Computerized adaptive testing (CAT) has become an important field of research for educational and psychological measurement. It provides tailored testing at the test taker level, focusing on the optimal administration of the items to improve accuracy and precision in individual ability estimation. Yet, practical implementation of CAT programs are still demanding both in terms of item bank creation and calibration, and require appropriate online platforms and suitable algorithms for underlying psychometric computations. The purpose of this workshop is twofold: (a) to briefly introduce the concepts of item response theory (IRT) and CAT in a practical, end-user approach; (b) to present a package of the R software, called catR, that performs all underlying IRT- and CAT-related calculations. This package is also adequate to perform simulation studies, which are most useful to assess the quality of an item and help in designing efficient CATs. Some live demonstrations of catR will be proposed to conclude the workshop. participants are invited to bring their laptops with R and RStudio software pre-installed. Electronic copies of the presentation and an R script with the code for illustrative examples will be provided. [less ▲]

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See detailPhenomenological Analysis of Existentialist Novels: Body, Emotion, Perception
Franck, Thomas ULg

Conference (2017, April 07)

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See detailConclusion
Marganne, Marie-Hélène ULg

in Marganne, Marie-Hélène; Ricciardetto, Antonio (Eds.) En marge du Serment hippocratique : contrats et serments dans le monde gréco-romain. Actes de la Journée d’étude internationale (Liège, 29 octobre 2014) (2017)

Detailed reference viewed: 19 (5 ULg)
See detailLes diagrammes syntaxiques du grammairien américain S. W. Clark (1847)
Mazziotta, Nicolas ULg

Scientific conference (2017, April 06)

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See detailPost-blast fire resistance of low-rise buildings through membrane action of composite floor slabs
Haase, Bryce; Elhami Khorasani, Negar; Gernay, Thomas ULg

Conference (2017, April 06)

Sever fires in buildings can lead to local failures, instability, partial or total collapse of the structure. In majority of the times, fire is a secondary event, after blast or impact, while the building ... [more ▼]

Sever fires in buildings can lead to local failures, instability, partial or total collapse of the structure. In majority of the times, fire is a secondary event, after blast or impact, while the building has experienced some damage. Examples of widely known events include the 1968 Ronan Point collapse in the UK, the 1995 Oklahoma City bombing, the World Trade Center Collapse in New York in 2001, the 2014 collapse of a building at New York’s Harlem neighborhood due to a gas explosion, and the recent 2015 collapse of a building at New York’s East Village also due to a gas explosion. The initial shock to the building can be conservatively modeled by removing an intermediate vertical supporting element (i.e. loss of load-carrying capacity in a critical element), leading to an increased span for composite floor slabs. In a lowrise building, if there is enough reinforcement throughout the slab and enough continuity and restraint, despite large deflections that will develop, the slab is capable of carrying the loads by membrane action. Fundamentally, the floor system behaves as an inverted dome structure with radial tensile forces and a compressive hoop stresses. This holds true at ambient temperature, yet a similar resisting mechanism forms during fire. Previous research and experimental work shows that fire performance of composite floor slabs can be used to reduce the fire protection requirement of the steel elements, i.e. the designer should take advantage of reserve capacity in the composite floor slab membrane action. The utilization of membrane action in the design of composite floor slabs has been used, to some extent, for mitigating collapse from single events (blast or fire only). Given that, often the initial blast is followed by a secondary fire event, this work investigates the system-level performance of low-rise damaged buildings subject to post-blast fires. The hypothesis is that, when incorporated in the design, low-rise buildings can withstand the post-blast fires through membrane action of composite floor slabs. Application of this concept, within a performance-based framework, can be used to avoid progressive collapse, or at the minimum increase fire resistance to allow for safe evacuation. This work investigates the design requirements for beam sizes, fire protection, concrete reinforcement and cover thickness to develop membrane action for a pre-defined fire resistance rating under cascading post-blast fires. [less ▲]

Detailed reference viewed: 22 (3 ULg)