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See detailIdentification of non-stationary dynamical systems using multivariate ARMA models
Bertha, Mathieu ULg; Golinval, Jean-Claude ULg

in Mechanical Systems and Signal Processing (2017), 88

This paper is concerned by the modal identification of time-varying mechanical systems. Based on previous works about autoregressive moving average models in vector form (ARMAV) for the modal ... [more ▼]

This paper is concerned by the modal identification of time-varying mechanical systems. Based on previous works about autoregressive moving average models in vector form (ARMAV) for the modal identification of linear time invariant systems, and time-varying autoregressive moving average models (TV-ARMA) for the identification of nonstationary systems, a time-varying ARMAV (TV-ARMAV) model is presented for the multivariate identification of time-varying systems. It results in the identification of not only the time-varying poles of the system but also of its respective time-varying mode shapes. The method is applied on a time-varying structure composed of a beam on which a mass is moving. [less ▲]

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See detailIn vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review
Pestieau, Aude ULg; Evrard, Brigitte ULg

in European Journal of Pharmaceutical Sciences (2017), 102

For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at ... [more ▼]

For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at the absorption site and this can be challenging for compounds with low aqueous solubility such as BCS class II (low solubility, high permeability) and IV (low solubility, low permeability) compounds. If the development of oral delivery formulations of these compounds is frequently challenging to formulation scientists in the pharmaceutical industry, the in vitro evaluation of these new formulations is also a great challenge. One alternative approach to overcome the problems encountered with conventional dissolution methods is the use of biphasic dissolution systems. This review provides an overview of the origin and the evolution over time of the biphasic systems and the growing interest among scientists regarding their suitability for establishing in vitro-in vivo correlations. The evolution of these systems and their applications from the 1960s to the present day, such as in system variants and improvements, analysis of complex formulations, discriminatory power, bio-relevance, precipitation and supersaturation visualization, etc. will be discussed. [less ▲]

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See detailCo-creating service recovery after service failure: The role of brand equity
Hazee, Simon ULg; Van Vaerenbergh, Yves; Armirotto, Vincent

in Journal of Business Research (2017), 74

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See detailFrom distant neighbours to bedmates: Exploring the synergies between the social economy and sustainable development
Hudon, Marek; Huybrechts, Benjamin ULg

in Annals of Public and Cooperative Economics (2017), 88(2),

To introduce this special issue we explore the conceptual and practical synergies between the social economy and sustainable development. New empirical evidence is presented on the emergence of these two ... [more ▼]

To introduce this special issue we explore the conceptual and practical synergies between the social economy and sustainable development. New empirical evidence is presented on the emergence of these two research fields and the increasing combination of these fields in the literature. Several avenues through which social enterprises can contribute to the transition towards sustainable development are then identified. This is followed by a discussion of how and why the combination can be particularly fruitful both for the social economy and for sustainability transition movements. We also highlight some important challenges facing the social economy with regard to its contribution to sustainable development. Finally we introduce the papers that constitute this special issue and show how they contribute, individually and collectively, to a better understanding of the increasing linkage between the social economy and sustainable development. [less ▲]

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See detailThe European Parliament as an actor in the global governance of culture: from voice to influence?
Vlassis, Antonios ULg

in Rioux, Michèle (Ed.) Culture, societies and digital technologies (2017)

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See detailFinite element model reduction for space thermal analysis
Jacques, Lionel ULg; Béchet, Eric ULg; Kerschen, Gaëtan ULg

in Finite Elements in Analysis and Design (2017), 127

To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on ... [more ▼]

To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on the clustering of a detailed mesh coming from a structural model for instance. The proposed method leads to a signi cant reduction of the number of radiative exchange factors (REFs) to compute and size of the corresponding matrix. It further keeps accurate conduction information by introducing the concept of physically meaningful super nodes. The REFs between the super nodes are computed through Monte Carlo ray-tracing on the partitioned mesh, preserving the versatility of the method. The resulting conductive-radiative reduced model is solved using standard iterative techniques and the detailed mesh temperatures can be recovered from the super nodes temperatures for further thermo-mechanical analysis. The proposed method is applied to a structural component of the Meteosat Third Generation mission and is benchmarked against ESATAN-TMS, the standard thermal analysis software used in the European aerospace industry. [less ▲]

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See detailProcess intensification of the synthesis of glycerol carbonate under microwave irradiation or continuous-flow conditions
Estager, Julien; Pleck, Julie; Gerardy, Romaric ULg et al

Conference (2017, May)

Despite low crude oil prices and the increasing access to shale gas, the establishment of a biobased economy remains a worldwide priority. An integrated biobased economy would not only consider renewable ... [more ▼]

Despite low crude oil prices and the increasing access to shale gas, the establishment of a biobased economy remains a worldwide priority. An integrated biobased economy would not only consider renewable biobased resources to provide industrially relevant chemicals, but would also redefine chemical processing by using greener, safer and more selective process technologies. The last few decades have witnessed the emergence of promising alternative energy sources such as microwave irradiation and alternative process technology such as continuous-flow reactors. Even if biobased chemicals are still marginal on the marklet compared to petrochemicals, many biorefineries are now able to convert biomass into biobased chemical building blocks of good purity on large scales. Amongst these products, glycerol – a side product of the biodiesel industry – is a particularly appealing chemical platform thanks to its high functionality and its wide availability. Various high-value added chemicals can be obtained from glycerol, among which glycerol carbonate retained our attention. Glycerol carbonate is an attractive glycerol derivative that can be used in many applications ranging from low-VOC solvent to polymer synthesis. Many publications describe its synthesis using different catalysts or alternative activation methods such as microwave. Our research effort in process intensification for the industrial valorization of biomass led us to develop an intensified carbonation process of glycerol under microwave irradiation, affording an unprecedented reactivity with short reaction times and high selectivity towards glycerol carbonate. Based on this preliminary study, and using the microwave-to-flow paradigm, continuous-flow processes using mesofluidic reactors have been developed to obtain glycerol carbonate in good yield and high purity. [less ▲]

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See detailSilica or Coal ? Design and Implementation of Dust Prevention in the Collieries in Western Economies, ca. 1930-1980
Geerkens, Eric ULg

in Rosental, Paul-André (Ed.) Silicosis. A World History (2017)

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See detailModeling the strain localization around an underground gallery with a hydro-mechanical double scale model; effect of anisotropy
van den Eijnden, AP; Bésuelle, Pierre; Collin, Frédéric ULg et al

in Computers and Geotechnics (2017), 85

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See detailSalmonella thyphimirium early onset neonatal sepsis
Thirion, Sophie ULg; RIGO, Vincent ULg; Snyers, Diane ULg et al

Poster (2017, May)

Background: Early onset neonatal sepsis due to salmonella spp is rare in developed countries. Vertical and horizontal transmissions were described, including faecal contamination of the birth canal. After ... [more ▼]

Background: Early onset neonatal sepsis due to salmonella spp is rare in developed countries. Vertical and horizontal transmissions were described, including faecal contamination of the birth canal. After a short incubation period, newborns may remain asymptomatic or present with sepsis or meningitis. Mortality rate as high as 58% were reported. Case Presentation Summary: We report a case of transplacental Salmonella Typhimurium infection in a premature infant. A mother with a one day history of fever and diarrhoea spontaneously delivered a premature boy at 35 weeks of gestation. On day 3, the infant presented with symptoms suggesting necrotizing enterocolitis: apnea, respiratory distress, feeding intolerance, bloody diarrhea and fever. Feeding were suspended and intravenous antibiotic therapy (ampicillin, amikacine and metronidazole) initiated. Laboratory data showed an inflammatory syndrome with elevated C-reactive proteine (71 mg/l), leukocytopenia (7270/mm3) and severe lymphopenia (580/mm3). Enterocolitis stage 1 (Bell classification) was diagnosed based on clinical and radiological evaluation. Salmonella spp were grown from the baby’s blood and stools and from the mother’s stools; the National Reference Center identified a Salmonella Typhimurium. Cerebrospinal fluid culture remained sterile. Clinical and biological evolutions were rapidly favourable with 14-days of cefotaxim IV. Maternal history revealed consumption of raw meat 3 days before delivery.Learning Points/Discussion: Salmonella spp should be considered in the differential diagnosis of early onset sepsis, particularly when mother presents gastrointestinal symptoms. Food safety education is crucial. The consumption of raw or uncooked meat during pregnancy should be avoided regardless toxoplasmosis immunization status. To avoid outbreaks in the neonatal ward (as reported in the literature), rapid detection and prompt institution of isolation and clustering measures are important. [less ▲]

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See detailMerci à vous!
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2017), 60(3),

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See detailIs Young Adolescents’ Self-Esteem Predicted by Peer Acceptance? A Gender Perspective
Gaudet, Olivier; Vollet, Justin; Véronneau, Marie-Hélène et al

Poster (2017, May)

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See detailDiscovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry
Echterbille, Julien; Gilles, Nicolas; Araoz, Romulo et al

in Toxicon (2017), 130

Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α ... [more ▼]

Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α-conotoxins, a family of peptide toxins produced by venomous cone snails. nAChRs are implicated in numerous physiological processes explaining why the design of new pharmacological tools and the discovery of potential innovative drugs targeting these receptor channels appear so important. This work describes a methodology developed to discover new ligands of nAChRs from complex mixtures of peptides. The methodology was set up by the incubation of Torpedo marmorata electrocyte membranes rich in nAChRs with BSA tryptic digests (>100 peptides) doped by small amounts of known nAChRs ligands (α-conotoxins). Peptides that bind to the receptors were purified and analyzed by MALDI-TOF/TOF mass spectrometry which revealed an enrichment of α-conotoxins in membrane-containing fractions. This result exhibits the binding of α-conotoxins to nAChRs. Negative controls were performed to demonstrate the specificity of the binding. The usefulness and the power of the methodology were also investigated for a discovery issue. The workflow was then applied to the screening of Conus ermineus crude venom, aiming at characterizing new nAChRs ligands from this venom, which has not been extensively investigated to date. The methodology validated our experiments by allowing us to bind two α-conotoxins (α-EI and α-EIIA) which have already been described as nAChRs ligands. Moreover, a new conotoxin, never described to date, was also captured, identified and sequenced from this venom. Classical pharmacology tests by radioligand binding using a synthetic homologue of the toxin confirm the activity of the new peptide, called α-EIIB. The Ki value of this peptide for Torpedo nicotinic receptors was measured at 2.2 ± 0.7 nM. [less ▲]

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See detailEvaluation of the implementation of integrated care for people with chronic conditions
Van Durme, Thérèse; Anthierens, Sibyl; Van Hecke, Ann et al

Conference (2017, May)

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See detailDiversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four Conus species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformatics
Degueldre, Michel; Verdenaud, Marion; Garikoitz, Legarda et al

in Toxicon (2017), 130

Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top ... [more ▼]

Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top candidates for the development of innovative drugs. Instead of relying on the classical, low-throughput bioassay-guided approach to identify innovative bioactive peptides, this work exploits a recent paradigm to access to venom diversity. This strategy bypasses the classical approach by combining high-throughput transcriptomics, proteomics and bioinformatics cutting-edge technologies to generate reliable peptide sequences. The strategy employed to generate hundreds of reliable sequences from Conus venoms is deeply described. The study led to the discovery of (i) conotoxins that belong to known pharmacological families targeting various GPCRs or ion-gated channels, and (ii) new families of conotoxins, never described to date. It also focusses on the diversity of genes, sequences, folds, and PTM's provided by such species. [less ▲]

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See detailFor a BRICS Agenda for Culture and the Creative Economy
Vlassis, Antonios ULg; Richieri-Hanania, Lilian

in Neuwirth, Rostam; Halis, Denis (Eds.) A BRICS-Lawyers' Guide to Global Cooperation (2017)

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See detailThe internet as a source of information used by women after childbirth to meet their need for information: A web-based survey.
Slomian, Justine ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg et al

in Midwifery (2017), 48

OBJECTIVE: the aims of this survey were: (a) to evaluate the need of information after childbirth and what questions do 'new' mothers ask themselves; (b) to assess why and how women use the Internet to ... [more ▼]

OBJECTIVE: the aims of this survey were: (a) to evaluate the need of information after childbirth and what questions do 'new' mothers ask themselves; (b) to assess why and how women use the Internet to meet their need of information; (c) to describe how the respondents evaluate the reliability of the information found; (d) to understand how the information found on the Internet affects women's decision-making; and (e) to appreciate how health professionals react to the information found by the women. DESIGN: this study used a large web-based survey that was widely broadcasted on various websites and social networks. SETTING AND PARTICIPANTS: belgian women who had a child under 2 years old and who agreed to participate were included in the study. FINDINGS: 349 questionnaires were valid for analyses. After childbirth, 90.5% of women admitted to using the Internet to seek information about themselves or about their baby, regardless of socioeconomic status or age. There were various reasons for seeking information on the Internet, but the most frequent reason the women expressed was to find information 'on their own' (88.1%). The most searched for topic was breastfeeding. The women believed that the information was quite useful (82.7%) but they assigned an average score of 5.3 out of 10 for the quality of the information they found on the Internet. Approximately 80% of the women felt that the Internet helped them control a decision that they made 'a little', 'often' or 'very often'. Professionals are not always willing to talk about information found on the Internet with mothers. Therefore, many women believed that health professionals should suggest reliable Internet websites for new mothers. CONCLUSIONS: the integration of the Internet and new technologies could be a useful tool during postpartum management. [less ▲]

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