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See detailConclusion
Marganne, Marie-Hélène ULg

in Nocchi Macedo, Gabriel; Scappaticcio, Marie Chiara (Eds.) Signes dans les textes, textes sur les signes. Érudition, lecture et écriture dans le monde gréco-romain. Actes du colloque international (Liège, 6-7 septembre 2013) (2017, January 20)

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See detailÉtude du cytosquelette de microtubules et implication de la vimentine dans le développement postnatal de la cochlée chez les rongeurs
Renauld, Justine ULg

Doctoral thesis (2017)

According to the World Health Organization, nearly 5% of the population suffers from hearing impairments. These can lead to social isolation, depression, or a reduction in professional abilities. There ... [more ▼]

According to the World Health Organization, nearly 5% of the population suffers from hearing impairments. These can lead to social isolation, depression, or a reduction in professional abilities. There are two types of hearing impairments : conductive hearing impairment and sensorineural hearing impairment. The first results from a defect in sound conduction at the level of the outer or middle ear, the latter results from defects in the cochlea or auditory nerve. In recent years, most studies on the organ of hearing have focused on sensory cells, which are actual receptors of auditory information, whereas supporting cells have been little explored. However, the latter, surrounding the sensory cells, contain a highly developed cytoskeleton, essential to the architecture of the mature organ of Corti. During this thesis work, we first observed the setting up of microtubules within the supporting cells of the organ of Corti. Our morphological data revealed important changes in microtubular cytoskeleton of these cells during the first week of life. We identified an arrangement of microtubules into two distinct bundles. We then demonstrated a modification in the morphology of these microtubules, revealing an increase in the diameter and the number of protofilaments of these cells. We finally demonstrated that tubulin βV has a more specific spatiotemporal distribution than the other tubulins. This characteristic suggests that tubulin βV plays an important role in the maturation of the Corti organ. In the second part of this thesis, we analyzed the involvement of vimentin in cochlear development, and more particularly in the opening of the intercellular spaces and in the myelination of the spiral ganglion, which is the first relay of the auditory pathway. In order to study the role of vimentin in the development of the inner ear, we examined the cochlear morphology and auditory capacities of vimentin deficient mice. Our results indicated that the absence of vimentin does not seem to affect the architecture of the organ of Corti. We then showed a slight morphological difference in the nerve fibers between wildtype and vimentin-knockout mice. We finally checked the hearing physiology of these mice and concluded that vimentin does not play a major role in hearing. [less ▲]

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See detailUber-like Models for the Electrical Industry
Ernst, Damien ULg

Speech/Talk (2017)

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See detailGlobal Simulation of UV atmospheric Emissions
Gonzalez-Galindo; Lopez-Valverde; Forget et al

Poster (2017, January 19)

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See detailGenetics of Pituitary Tumor Syndromes
Daly, Adrian ULg; BECKERS, Albert ULg

in Melmed, Shlomo (Ed.) The Pituitary (2017)

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See detailMoresnet-Neutre (1816-1919): Histoire et mémoire d'une curiosité géopolitique
Brüll, Christoph ULg

Conference given outside the academic context (2017)

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See detailA persistent meteoric layer in Mars' atmosphere
Crismani; Schneider; Plane et al

Poster (2017, January 18)

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See detailPresent-day central African forest is a legacy of the 19th century human history
Morin, Julie ULg; Fayolle, Adeline ULg; Favier, Charly et al

in eLife (2017)

The populations of light-demanding trees that dominate the canopy of central African forests are now aging. Here, we show that the lack of regeneration of these populations began ca. 165 ya (around 1850 ... [more ▼]

The populations of light-demanding trees that dominate the canopy of central African forests are now aging. Here, we show that the lack of regeneration of these populations began ca. 165 ya (around 1850) after major anthropogenic disturbances ceased. Since 1885, less itinerancy and disturbance in the forest has occurred because the colonial administrations concentrated people and villages along the primary communication axes. Local populations formerly gardened the forest by creating scattered openings, which were sufficiently large for the establishment of light-demanding trees. Currently, common logging operations do not create suitable openings for the regeneration of these species, whereas deforestation degrades landscapes. Using an interdisciplinary approach, which included paleoecological, archaeological, historical, and dendrological data, we highlight the long-term history of human activities across central African forests and assess the contribution of these activities to present-day forest structure and composition. The conclusions of this sobering analysis present challenges to current silvicultural practices and to those of the future. [less ▲]

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See detailFlexible Bayesian Models for Interval-Censored Survival Data
Cetinyürek, Aysun ULg

Doctoral thesis (2017)

Interval-censored time-to-event data arise frequently in clinical trials and longitudinal studies, where the event of interest is only known to have occurred between the two consecutive visits. Interval ... [more ▼]

Interval-censored time-to-event data arise frequently in clinical trials and longitudinal studies, where the event of interest is only known to have occurred between the two consecutive visits. Interval-censoring is a natural generalization of right censored time-to-event data. For right-censored data, extensive number of statistical techniques are available to tackle most research questions under a variety of assumptions. However, for interval-censored data, less well developed procedures are available. A sparse offer in statistical softwares to handle this type of censoring has driven many researchers to use imputation techniques, especially right-point or mid-point imputation. However such imputation strategies can lead to misleading inferences. Our thesis proposes and studies the properties of innovative methods to analyze such data. In the first part of the text, we have extended a Bayesian density estimation procedure for grouped data to estimate hazard ratios and survival functions from interval-censored data. If one further assumes proportionality of the hazards, the proposed strategy also provides estimates of global covariate effects. Clearly, the proposed method provides very good estimates for the regression coefficients and successfully approximates the baseline survival function when the mean interval width is smaller than some threshold defined from the data standard deviation. In a Cox proportional hazards model, the observations are assumed to be independent. However, this may not be true in certain situations where the observed units are clustered or subject to multiple measurements. A number of approaches generalizing Cox's PH model to handle correlated interval-censored data have been proposed in the literature. The shared frailty model is a popular tool to analyze correlated right-censored time-to-event data. Frailty models have also been adapted to handle interval-censored data. In the case of interval-censored time-to-event data, the inclusion of frailties results in complicated intractable likelihoods. In the second part of this thesis, we propose flexible frailty models for analyzing such data by assuming a smooth flexible form for the conditional time-to-event distribution and a parametric or a flexible form for the frailty distribution. It has been indicated in the literature in different contexts that the misspecification of the random effect distribution can influence the estimation of quantities of primary interest, like the fixed effects. To circumvent such misspecification, we have suggested modeling the distribution of the frailty in a flexible way using P-splines or a gamma shape mixture (GSM) distribution. The biggest advantage of using a flexible specification for the density of frailty arises when its shape is of specific interest. If it is considered as a nuisance, assuming a simpler lognormal or gamma frailty would be an adequate solution to draw conclusions related to other model parameters, such as regression coefficients and variance of frailties. Indeed, it was shown in the simulation study that the regression parameter estimates in a shared frailty PH model are robust to the misspecification of the frailty density. Moreover the use of a flexible form for the frailty does not cause any loss of precision in the estimation of regression parameters when compared to the simpler parametric frailty model. Both models provide the possibility to visualize the baseline density and survival functions. Given sufficiently large sample sizes, the flexible approach produces smooth and accurate posterior estimates for the baseline survival function and for the frailty density, and can correctly detect and identify unusual frailty density forms. [less ▲]

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See detailLeidenfrost effect at its limits
Maquet, Laurent ULg

Doctoral thesis (2017)

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See detailGlobal UV Imaging by MAVEN/IUVS: Diurnal Cloud Formation, Dust Storms and Atmospheric Scattering.
Schneider; Deighan; Jain et al

Conference (2017, January 17)

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See detailThree Types of Aurora observed by MAVEN/IUVS: Implications for Mars’ upper Atmosphere Energy Budget
Connour; Schneider; Jain et al

Poster (2017, January 17)

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See detailIs Büchi's theorem useful for you? (for an audience of logicians)
Rigo, Michel ULg

Conference (2017, January 17)

Almost a century ago, Presburger showed that the first order theory of the natural numbers with addition is decidable. Following the work of B\"uchi in 1960, this result still holds when adding a function ... [more ▼]

Almost a century ago, Presburger showed that the first order theory of the natural numbers with addition is decidable. Following the work of B\"uchi in 1960, this result still holds when adding a function $V_k$ to the structure, where $V_k(n)$ is the largest power of $k\ge 2$ diving $n$. In particular, this leads to a logical characterization of the $k$-automatic sequences. During the last few years, many applications of this result have been considered in combinatorics on words, mostly by J. Shallit and his coauthors. In this talk, we will present this theorem of B\"uchi where decidability relies on finite automata. Then we will review some results about automatic sequences or morphic words that can be proved automatically (i.e., the proof is carried on by an algorithm). Finally, we will sketch the limitation of this technique. With a single line formula, one can prove automatically that the Thue-Morse word has no overlap but, hopefully, not all the combinatorial properties of morphic words can be derived in this way. We will not assume any background in combinatorics on words from the audience. [less ▲]

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See detailLes institutions politiques belges
Grandjean, Geoffrey ULg

Learning material (2017)

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See detailNO Nightglow studies status
Stiepen, Arnaud ULg; Jain; Deighan et al

Conference (2017, January 16)

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See detailLa théorie du complot : un moyen pour expliquer le monde !
Debras, François ULg

Conference given outside the academic context (2017)

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See detailPrésentation de cas cliniques
WANG, François-Charles ULg

Scientific conference (2017, January 16)

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See detailCryopreservation of chicken primordial germ cells by vitrification and slow-freezing: a comparative study
Tonus, Céline ULg; Connan, Delphine ULg; Waroux, Olivier ULg et al

in Theriogenology (2017), 88

In the present study, we compare a classical slow freezing method and an aseptic vitrification technique to cryopreserve a stable Primordial Gem Cells (PGCs) line issued from the Ardennaise chicken breed ... [more ▼]

In the present study, we compare a classical slow freezing method and an aseptic vitrification technique to cryopreserve a stable Primordial Gem Cells (PGCs) line issued from the Ardennaise chicken breed. Viability immediately after warming was close to 80% and did not differ between the two cryopreservation methods. Proliferation tended to be slower for both cryopreservation methods compared to controls, but the difference was significant only for vitrification. No difference was found between the two methods after flow cytometry analysis of SSEA-1 expression and RT-PCR on several factors related to PGCs phenotype. After one week in culture, all cryopreserved cells reached controls main morphological and expanding (viability/proliferation) features. However, slow freezing generated more unwanted cells clusters than vitrification. After injection of the PGCs into recipient embryos, vitrified PGCs showed a clear, yet not significant, tendency to colonize the gonad at a higher rate than slow frozen PGCs. Slow freezing in cryovials remains simple, inexpensive and less technically demanding than vitrification. Nevertheless, the intrinsic advantages of our aseptic vitrification method and the present study suggest that this should be considered as safer than classical slow freezing for cryopreserving chicken PGCs. [less ▲]

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