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See detailConclusion
Veymiers, Richard ULg

Conference (2016, September)

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See detailVoyage[s] à travers le thymus
Geenen, Vincent ULg

Book published by Presses Universitaires de Liège (2016)

Cet ouvrage concis s'intéresse au thymus, un organe dont la fonction a échappé si longtemps au monde de la science que d'aucuns le considèrent encore aujourd'hui comme un vestige de l'évolution. Vous le ... [more ▼]

Cet ouvrage concis s'intéresse au thymus, un organe dont la fonction a échappé si longtemps au monde de la science que d'aucuns le considèrent encore aujourd'hui comme un vestige de l'évolution. Vous le connaissez néanmoins très bien car vous avez certainement consommé de très savoureux 'ris de veau' qui sont la dénomination culinaire du thymus de cet animal. Ce n'est qu'au cours des 60 dernières années environ que cet organe a livré un à un ses secrets les plus intimes jusqu'à occuper la place essentielle de 'petit cerveau' de notre système de défenses immunitaires. Cet essai concerne donc aussi l’immunologie, la science qui étudie les mécanismes de notre système de défenses, contre les agressions infectieuses surtout, en un mot l’immunité. Dès la fondation de cette nouvelle science à la fin du XIXe siècle, les immunologistes ont été confrontés à cet important paradoxe: comment notre système immunitaire, capable de réagir contre une multitude d’agents étrangers (ce qui est désigné comme le ‘non-soi’), est-il heureusement incapable en conditions normales d’agresser l’organisme qui l’héberge (le ‘soi’) ? Cette impossibilité du système immunitaire de réagir contre le ‘soi’ s’appelle la ‘tolérance immunitaire’ et elle est devenue aujourd’hui la pierre angulaire du fonctionnement normal de ce système. La rupture de cette tolérance est à l’origine des maladies dites ‘auto-immunes’. Il en existe environ 70 dont les plus connues sont le diabète juvénile insulino-dépendant (diabète de type 1) qui frappe les enfants et les jeunes adolescents, la plupart des affections de la glande thyroïde, la sclérose en plaques, le psoriasis et la polyarthrite rhumatoïde. J’ai souhaité inviter le lecteur à pénétrer dans un monde qui était encore presque inconnu il y a moins de soixante ans, celui du thymus qui peut être qualifié aujourd’hui sinon de ‘cerveau’, au moins de programmeur central de la tolérance immunitaire. Les travaux menés par mon groupe à l’Université de Liège ont établi que le thymus constitue un carrefour crucial entre les trois grands systèmes de communication intercellulaire des espèces vivantes, les systèmes nerveux, endocrine et immunitaire. Ils ont démontré que le thymus joue un rôle unique dans la programmation de la tolérance immunitaire vis-à-vis des systèmes nerveux et endocrine. Ces études ont aussi établi qu’un dysfonctionnement du thymus joue un rôle moteur dans le développement des maladies auto-immunes spécifiques des glandes endocrines. En un mot, c’est d’abord le thymus qui est malade et non les organes touchés par le processus auto-immun pathogène qui résulte de cette pathologie du thymus. Mon plus vif espoir aujourd’hui est que la découverte de ce nouveau concept se traduise un jour par l’invention d’un nouveau type de vaccination contre le diabète des enfants et des adolescents. Quelles sont les raisons qui ont motivé ma candidature au Prix littéraire Prince Alexandre de Belgique 2014. 1° La première était de témoigner ma reconnaissance à l’égard de la Fondation cardiologique Princesse Lilian qui a joué un rôle déterminant dans l’orientation de ma carrière de médecin-chercheur. En effet, cette Fondation a organisé en 1984 à Bruxelles un symposium international consacré au contrôle exercé par le système nerveux sur le système immunitaire. Mon promoteur, le regretté Pr Paul Franchimont, avait assisté à ce symposium et me conseilla vivement d’essayer de développer des activités de recherches dans ce tout nouveau domaine. C’est dans ce même esprit de reconnaissance à la Fondation Princesse Lilian que j’ai proposé que la chaire internationale du même nom soit confiée en 2015 à mon confrère allemand, lui aussi spécialiste du thymus, le Pr Bruno Kyewski de l’Institut allemand de la recherche contre le cancer à Heidelberg en Allemagne. Cette proposition a été acceptée et la leçon inaugurale de cette chaire a eu lieu le 16 mars 2015 en la Grande Salle Académique de l’Université de Liège. 2° Mon goût pour la littérature, qu’elle soit romancière, historique, scientifique ou philosophique, constitue incontestablement la deuxième raison de ma candidature au Prix Prince Alexandre. Combien de fois n’ai-je lu une œuvre littéraire en m’interrogeant si je serais capable moi-même d’écrire un jour un livre ? C’est aussi en me plongeant dans la littérature que j’ai vécu les plus beaux voyages initiatiques de la pensée. 3° Une autre raison essentielle qui m’a poussé à rédiger mes « Voyage(s) à travers le thymus » est la suivante. L’équipe de recherche que j’anime au Centre d’Immunologie du GIGA de Liège a contribué à mettre au jour un phénomène essentiel de la vie qui est apparu avec le premier thymus il y a environ 450 millions d’années chez les poissons cartilagineux comme la raie ou le requin. Cette ‘découverte’ d’un secret inouï de la vie suscite alors en vous une sensation d’émerveillement du même ordre que l’émotion qui vous étreint quand vous écoutez l’Oratorio de Noël ou la Passion selon Saint-Mathieu de Jean-Sébastien Bach, quand vous regardez un tableau de Piero de la Francesca, ou quand vous contemplez une merveille de la Nature comme le Grand Canyon du Colorado ou le lever du soleil sur Massif du Hoggar depuis l’ermitage du Père de Foucault à l’Assekrem. Vous pouvez très bien vivre seul un pareil émerveillement mais le premier désir que vous ressentez au fond de vous-même est de le partager avec vos proches. Ce désir irrésistible a joué lui aussi un rôle déterminant dans ma décision de consacrer la majeure partie de mes soirées de l'été 2014 à écrire ce texte et, surtout, à le rédiger de manière compréhensible pour toutes et tous. Et c’est là que réside la plus grande difficulté car, comme le disait Albert Einstein, « Si vous ne pouvez expliquer un concept à un enfant de six ans, c'est que vous ne le comprenez pas complètement ». 4° Enfin, les trente-cinq années de ma vie de médecin engagé dans la recherche ont exercé un impact considérable sur ma propre conception de la vie et de ses innombrables mystères. Mon essai se clôture par un témoignage personnel décrivant comment ces différents voyages ont nourri ma réflexion à propos des rapports entre la science et la foi. J’ai tenté d’expliquer qu’il était encore possible aujourd’hui de rester chrétien en devenant un scientifique quelque peu écouté, comment mes vies professionnelle et spirituelle pouvaient se nourrir l’une de l’autre tout en respectant leur indépendance. [less ▲]

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See detailCreating undocumented EU migrants through welfare: The case of Belgium
Lafleur, Jean-Michel ULg; Mescoli, Elsa ULg

Conference (2016, September)

In the dual context of increased Central and Eastern European migration and of the global financial and economic crisis, several Northern European Member States have implemented (or debated) reforms of ... [more ▼]

In the dual context of increased Central and Eastern European migration and of the global financial and economic crisis, several Northern European Member States have implemented (or debated) reforms of their welfare regimes to restrict access to migrants coming from other EU Member States. As the debates on the so-called “welfare tourism” are intensifying in different parts of the EU, we can observe a growing trend among Member States to use welfare policies as instruments to limit the mobility of certain EU migrants. This stance is best illustrated with Prime Minister Cameron’s demand for four-year ban on EU migrants claiming in-work benefits. In Belgium, too, EU citizens have been particularly affected by this adverse context as the Migration Office (Office des Etrangers) has intensified controls against EU residents receiving welfare benefits. With this policy, authorities have been using a restrictive interpretation of the European Directive 2004/38 that allows Member States to remove residence permits from EU citizens who represent an “unreasonable burden on state finances”. As a consequence, the number of EU citizens expelled from Belgium on a yearly basis has jumped from 343 to 2,042 between 2010 and 2014. In this paper, we propose to focus on those EU citizens who see their freedom of circulation in the EU restricted after claiming social protection in their country of residence. Relying on fieldwork conducted with Italian and Romanian migrants who experienced the removal of their residence permit, we discuss the different resilience strategies of those EU citizens faced with the legal obligation to leave: such strategies include returning to the homeland, refusing to leave, mobilizing the support of migrant organizations, introducing individual appeals, and seeking to regularize their administrative status. In particular, we shall focus on the experience of EU migrants who have decided to stay in Belgium and experience the status of an undocumented EU migrant. This peculiarity of this status is visible in three respects: 1) expulsion is not enforced by local authorities, 2) migrants continue to be able to circulate between their homeland and the country where they no longer have a residence permit, and 3) they have a possibility to regularize their status if they can demonstrate to municipal authorities that they no longer represent “a burden” on Belgium’s public finances. Overall, confronting our data to the rich literature on undocumented third country nationals, we discuss the limits of EU citizenship as experienced by those who are denied the right to free movement. This paper relies primarily on multi-sited ethnographic fieldwork (in progress) conducted with Italian and Romanian migrants in Brussels and with individuals of the same nationality who decided to leave Belgium and return to their home country after the removal of their residence permit. Additional fieldwork includes semi-directed interviews with civil society organizations, trade unions, and consular authorities. The data collection process started in May 2014 and is expected to be finished in May 2016. [less ▲]

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See detail"Traduction et médiation: pour une pensée aporétique de la traduction postcoloniale"
Bada, Valérie ULg

in Servais, Christine (Ed.) Penser la médiation. De la théorie aux terrains. (2016)

Si l’apport conceptuel de la médiation à la traductologie est fécond, il ne montre pas moins ses limites, surtout dans un domaine tel que celui de la traduction postcoloniale qui est traversé par des ... [more ▼]

Si l’apport conceptuel de la médiation à la traductologie est fécond, il ne montre pas moins ses limites, surtout dans un domaine tel que celui de la traduction postcoloniale qui est traversé par des rapports de force, visibles et/ou sous-jacents, entre discours dominant et résistances contre-discursives [less ▲]

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See detailGait pattern of healthy old people for dual task walking condition
GILLAIN, Sophie ULg; Boutaayamou, Mohamed ULg; Schwartz, Cédric ULg et al

in Gerontechnology (2016, September)

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See detailGait pattern of healthy old people for fast walking condition
GILLAIN, Sophie ULg; Boutaayamou, Mohamed ULg; Schwartz, Cédric ULg et al

in Gerontechnology (2016, September)

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See detailProduction of word stress by French speaking CLIL and non-CLIL learners of Dutch
Hiligsmann, Philippe; Rasier, Laurent ULg; Degrave, Pauline

Conference (2016, September)

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See detailMonitoring topography of laboratory fluvial dike models subjected to breaching based on a laser profilometry technique
Rifai, Ismail ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in International Symposium on River Sedimentation: Stuttgart 19th-22d september 2016 (2016, September)

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See detailThe np- Control Charts with the Guaranteed In-Control Performance
Faraz, Alireza ULg; Heuchenne, Cédric ULg

E-print/Working paper (2016)

In this paper, we evaluate the in-control performance of np-control charts with estimated parameters. We then apply the bootstrap method to adjust the control charts’ limits to guarantee the desired in ... [more ▼]

In this paper, we evaluate the in-control performance of np-control charts with estimated parameters. We then apply the bootstrap method to adjust the control charts’ limits to guarantee the desired in-control average run length (ARL0) value in monitoring stage. The adjusted limits ensure that ARL0 would take a value greater than the desired value (say, B) with a certain specified probability, that is Pr⁡(ARL_0>B)=1-ρ. We finally provide users with tables which with practitioners do not need to do bootstrapping Phase I data set to obtain the control limit thresholds. [less ▲]

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See detailStatistically Bundled Shewhart Control Charts for Monitoring Delivery Chains Systems
Foster, Earnest; Faraz, Alireza ULg; Heuchenne, Cédric ULg

in European Journal of Industrial Engineering (2016)

Continuous monitoring of Delivery Time variables by means of control charts in a delivery chain is a very recent application of Statistical Process Control (SPC) to the service sector. The aim of the ... [more ▼]

Continuous monitoring of Delivery Time variables by means of control charts in a delivery chain is a very recent application of Statistical Process Control (SPC) to the service sector. The aim of the proposed method is to provide supply chain decision makers with an easy to be managed tool monitoring the current functioning state of the delivery chain. The implementation of SPC control charts makes it possible to limit over-corrections to false alarm conditions and to maintain at an acceptable level the safety stock, with a consequent reduction of the overall management costs of the delivery chain. An illustrative example shows the proposed control chart implementation in a real delivery chain. [less ▲]

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See detailMicroorganisms and semiochemicals to manipulate aphidophagous predators
Verheggen, François ULg

Conference (2016, August)

Semiochemicals provide a powerful way for organisms to communicate and coordinate their behaviors. But they also represent opportunities for other organisms to intercept and exploit such signals. There ... [more ▼]

Semiochemicals provide a powerful way for organisms to communicate and coordinate their behaviors. But they also represent opportunities for other organisms to intercept and exploit such signals. There are now numerous examples of natural enemies eavesdropping the intraspecific communication of their prey to better locate them. Aphid natural enemies, including predators and parasitoids, frequently exhibit innate responses to chemical cues reliably associated with aphids, and there is also abundant evidence that learning of profitable chemical cues frequently occurs. Thenceforth, the efficiency of aphid natural enemies to locate their prey is mainly based on their ability to perceive and orientate toward aphid-associated semiochemicals. Aphid predators were shown to respond to different groups of aphid-related semiochemicals, including aphid-induced plant volatiles; aphid pheromones and the more recently identified bacteria-produced honeydew volatiles. These laboratory studies suggest potentially promising avenues for the deployment of aphid-associated semiochemicals for the management of these pest species. While laboratory experiments are invaluable tools for revealing mechanisms, additional field studies are however needed to test ecological relevance of the observed effects. Although it is now possible to attract naturally occurring aphid predators in a crop field using semiochemicals, future work should more fully explore the broader ecological context in which signaling occurs. The information gained from a deeper understanding of the chemical ecology of aphid-natural enemy interaction will enhance our understanding of the chemical biology and ecology of aphids, and may facilitate the design of novel control strategies. [less ▲]

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See detailLa légation des Pays-Bas en cour de Rome au temps de l’agent Laurent du Blioul (1573-1598): Une légation au cœur des réseaux de la monarchie de Philippe II
Regibeau, Julien ULg

in Actes du neuvième congrès de l'Association des Cercles francophones d'Histoire et d'Archéologie de Belgique (2016, August)

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See detailCollaborative Care regarding major depressed patients: A review of guidelines and current practices
Van den Broeck, Kris; Remmen, Roy; Vanmeerbeek, Marc ULg et al

in Journal of Affective Disorders (2016), 200

Major Depressive Disorder (MDD) is a severe and common mental disorder. A growing body of evidence suggests that stepped and/or collaborative care treatment models have several advantages for severely ... [more ▼]

Major Depressive Disorder (MDD) is a severe and common mental disorder. A growing body of evidence suggests that stepped and/or collaborative care treatment models have several advantages for severely depressed patients and caretakers. However, despite the availability of these treatment strategies and guidance initiatives, many depressive patients are solely treated by the general practitioner (GP), and collaborative care is not common. In this paper, we review a selected set of international guidelines to inventory the best strategies for GPs and secondary mental health care providers to collaborate when treating depressed patients. Additionally, we systematically searched the literature, listing potential ways of cooperation, and potentially supporting tools. We conclude that the prevailing guidelines only include few and rather vague directions regarding the cooperation between GPs and specialised mental health practitioners. Inspiring recent studies, however, suggest that relatively little efforts may result in effective collaborative care and a broader implementation of the guidelines in general. [less ▲]

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See detailPhonological acquisition in CLIL- and non-CLIL education
Rasier, Laurent ULg

Conference (2016, August)

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See detailEnhancing Cover Song Identification with Hierarchical Rank Aggregation
Osmalsky, Julien ULg; Van Droogenbroeck, Marc ULg; Embrechts, Jean-Jacques ULg

in Proceedings of the 17th International for Music Information Retrieval Conference (2016, August)

Abstract Cover song identification involves calculating pairwise similarities between a query audio track and a database of reference tracks. While most authors make exclusively use of chroma features ... [more ▼]

Abstract Cover song identification involves calculating pairwise similarities between a query audio track and a database of reference tracks. While most authors make exclusively use of chroma features, recent work tends to demonstrate that combining similarity estimators based on multiple audio features increases the performance. We improve this approach by using a hierarchical rank aggregation method for combining estimators based on different features. More precisely, we first aggregate estimators based on global features such as the tempo, the duration, the loudness, the beats, and the average chroma vectors. Then, we aggregate the resulting composite estimator with four popular state-of-the-art methods based on chromas as well as timbre sequences. We further introduce a refinement step for the rank aggregation called “local Kemenization” and quantify its benefit for cover song identification. The performance of our method is evaluated on the Second Hand Song dataset. Our experiments show an significant improvement of the performance, up to an increase of more than 200 % of the number of queries identified in the Top-1, compared to previous results. [less ▲]

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See detailHydrocarbon biostimulation and bioaugmentation in organic carbon and clay-rich soils
Masy, Thibaut ULg; Demanèche, Sandrine; Tromme, Olivier et al

in Soil Biology & Biochemistry (2016), 99

Hydrocarbon-contaminated organic carbon-rich clayey soils are challenging for bioremediation stakeholders since the pollutant is heterogeneously distributed and poorly bioavailable due to its strong ... [more ▼]

Hydrocarbon-contaminated organic carbon-rich clayey soils are challenging for bioremediation stakeholders since the pollutant is heterogeneously distributed and poorly bioavailable due to its strong adsorption on clay and organic particles. In addition, biodegradation rates are restricted by limited diffusion of oxygen and nutrients to hydrocarbon-degrading aerobes. This study assessed the benefits of bioaugmentation with the strain Rhodococcus erythropolis T902.1 versus those from biostimulation and anaerobic natural attenuation in terms of hydrocarbon (HC) degradation efficiency and changes in the bacterial community structure in a diesel-polluted clay-rich soil. Three soil samples with a similar total organic content but with a different HC concentration (0.2, 1.0 and 6.5 g/kg) were compared in a microcosm experiment. Despite a limitation in oxygen transfer, R. erythropolis T902.1 enhanced a greater HC degradation compared to the biostimulation treatment. However, this advantage decreased with time as the proportion of Rhodococci declined from 25% initially to 1% of the global community after 80 days of treatment. Similarly, the alkB gene proportion in bioaugmented soils decreased to levels close to those of biostimulated soils. Consequently, further engineering was suggested to improve the resilience of the inoculum to ensure its long-term presence and activity in such polluted environments. [less ▲]

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See detailEVALUATION OF FISH EXPOSURE TO POP-LIKE (ORGANOTIN) COMPOUNDS IN SEPETIBA BAY (RIO DE JANEIRO STATE, BRAZIL) THROUGH HEPATIC TOTAL TIN CONCENTRATIONS
Paiva, TC; Schilithz, PF; Bisi, TL et al

in Organohalogen Compounds (2016, August)

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See detailStable biofilms of Rhodococcus erythropolis T902.1 in draining pavement structures for runoff water decontamination
Masy, Thibaut ULg; Bertrand, Christelle ULg; Paul-Marie, Xavier et al

in International Biodeterioration & Biodegradation (2016), 112

Permeable Pavement Systems (PPS) are sustainable devices designed to collect, store and treat urban stormwater before its release into the ground. However, this system must sufficiently retain pollutants ... [more ▼]

Permeable Pavement Systems (PPS) are sustainable devices designed to collect, store and treat urban stormwater before its release into the ground. However, this system must sufficiently retain pollutants brought by water runoff in order to comply with the current legislation. This study aims at evaluating the implementation in PPS of a hydrocarbonoclastic bacterium, Rhodococcus erythropolis T902.1, in terms of resilience and improvement of the degrading capacity. First results revealed that this strain could durably colonize the different gravels used in the construction of PPS. A 15-month experience in a real parking area showed that this biofilm remained viable without any replenishment of nutrients or bacteria. During accelerated pollution tests at a pilot scale, the structure bioaugmented with pre-coated biofilms was more efficient than a non-inoculated structure to limit hydrocarbon leaching below 50 μg L−1 and to degrade hydrocarbons adsorbed to the gravels. Over the long term, this innovative assembly should maintain the degrading capacity of PPS and ensure an effective treatment of stormwater before its infiltration into the soil. [less ▲]

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