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See detailLa reconnaissance de la maladie mentale : perspectives en troisième et en première personne
Englebert, Jérôme ULg

Conference (2017, May 20)

La distinction des perspectives en première et troisième personnes est un apport récent et décisif de la phénoménologie à la psychologie clinique et à la psychopathologie (Parnas, Sass & Zahavi, 2012). La ... [more ▼]

La distinction des perspectives en première et troisième personnes est un apport récent et décisif de la phénoménologie à la psychologie clinique et à la psychopathologie (Parnas, Sass & Zahavi, 2012). La perspective en troisième personne consiste en l’attribution, depuis une position externe, de signes cliniques repérés indépendamment du ressenti exprimé par le patient. L’exemple typique de ces signes est le délire et l’hallucination du schizophrène. Ces symptômes cristallisent les difficultés qu’éprouve le sujet à se reconnaitre affecté du trouble (l’anosognosie), et ce point est considéré par de nombreux modèles comme une cible thérapeutique prioritaire. Il est attendu que le patient adopte la position propre à son évaluateur, et externe à sa subjectivité intrinsèque. La perspective en première personne, concentre quant à elle son attention sur l’expérience subjective exprimée par le patient. Si l’on reprend le cas de la schizophrénie, ce sont la « perte de l’évidence naturelle » des choses, un « trouble du sens commun » ou un « sentiment de diminution du soi » qui sont verbalisés. Ce pas de côté de la vision omnisciente du médical, assumant une remise en cause du pouvoir de domination qu’entraine la perspective en troisième personne, se révèle être un outil psychothérapeutique pertinent. Il désacralise le problème de l’anosognosie et ouvre la voie à une perspective intersubjective, co-construite. Nous constaterons que la reconnaissance de la maladie en troisième personne, à laquelle on intègre une considération de la perspective en première personne, permet au patient d’être partie prenante du processus thérapeutique. [less ▲]

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See detailDu définitif sur du provisoire...
Englebert, Jérôme ULg; Follet, Valérie

Conference (2017, May 18)

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See detailRadiohead and Prog Rock
Delville, Michel ULg

Conference (2017, May 18)

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See detailLe manuel de grammaire latine de Dosithée : quelle méthode d'apprentissge ?
Rochette, Bruno ULg

Conference (2017, May 15)

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See detailBelgian speleothem records Holocene cold events?
Allan, Mohammed ULg; Deliège, Adrien ULg; Nicolay, Samuel ULg et al

Poster (2017, May 12)

Speleothem is now regarded as valuable archive of climatic conditions on the continents, offering a number of advantages relative to other continental climate proxy recorders such as lake sediments and ... [more ▼]

Speleothem is now regarded as valuable archive of climatic conditions on the continents, offering a number of advantages relative to other continental climate proxy recorders such as lake sediments and peat cores. High spatial resolution measurements of Mg, Al, Sr, Ba were realized by using laser-ablation inductively coupled plasma mass spectrometry in the Belgian Pere Noel cave. A stalagmite from the Pere Noel (PN) cave representing 12000 years dated by U/Th method. Trace element variations in speleothem are a reflection of hydrochemical conditions. These changes were interpreted as indications of changes in climate in the Han-sur-Lesse region. The similar patterns found in δ 18O, δ 13C and chemical composition along the Pere Noel stalagmite suggests that trace elements in speleothems have the potential to provide high resolution insights into palaeoclimatic variability during the Holocene. A deeper analysis reveals several periods of significant rapid climate change during the Holocene (at 10.7-9.2 ka, 8.2-7.9 ka, 7.2-6.2 ka, 4.8-4.5 ka, and 3-2.4 ka BP), which are similar to the cold events detected from different natural paleoclimate archivers. A comparison between the geochemical analysis of Père Noël speleothem and solar activity (sunspot number) reveals a significant correlation. Spectral analysis methods reveal common solar periodicities (Gleissberg cycle, de Vries cycle, unnamed 500 year, Eddy cycles, and Hallstatt cycle). The geochemical analyses have the potential to prove that PN speleothem is sensitive to changes in solar activity on centennial and millennial timescales during the Holocene. [less ▲]

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See detailLes constructions relatives du néo-égyptien. Une approche fonctionnelle
Sojic, Nathalie ULg

Doctoral thesis (2017)

Cette dissertation doctorale se propose d’étudier les constructions relatives du néo-égyptien suivant une approche fonctionnelle. Elle offre une première étude large de la relativisation pour cet état de ... [more ▼]

Cette dissertation doctorale se propose d’étudier les constructions relatives du néo-égyptien suivant une approche fonctionnelle. Elle offre une première étude large de la relativisation pour cet état de langue sous l’angle de la variation linguistique. Elle comprend deux grandes parties : les chapitres 1 à 4 sont théoriques, les chapitres 5 à 9 constituent la recherche à proprement parler. Le chapitre 10 conclut l’ensemble. Le premier chapitre (Ch. 1) propose un état de la question des études relatives aux constructions relatives en égyptien ancien et met en avant le manque criant de vision d’ensemble des descriptions et des études proposées jusqu’à présent, tous états de langue confondus. Le chapitre suivant (Ch. 2) définit le cadre théorique dans lequel s’inscrit l’étude, à savoir les bases conceptuelles et terminologiques issues du fonctionnalisme en linguistique. J’y fais également le point sur le recours, en égyptologie, à ces théories. Le troisième chapitre (Ch. 3) est consacré à la délimitation et à la description du corpus, l’accent étant mis sur la variation linguistique (en diachronie et en synchronie dynamique). Je propose ensuite (Ch. 4) un préambule ou un excursus relatif à la définition des « parties du discours », catégories d’après lesquelles sont classées les unités qui composent la phrase. La plupart des études fonctionnelles, dont la présente, ont pour objet l’une de ces catégories. Le cinquième chapitre (Ch. 5) offre une vue d’ensemble des constructions relatives et constructions apparentées en égyptien ancien (ancien, moyen et néo). La description, très générale, vise à rendre compte de leurs principales caractéristiques typologiques et des particularités de la langue étudiée. Le chapitre suivant (Ch. 6) est consacré à l’histoire du système : il en présente les grandes tendances distributionnelles aux stades de la langue antérieurs au néo-égyptien. Cette synthèse montre l’existence de jeux d’oppositions à l’œuvre à une époque donnée et permet d’en constater l’évolution au stade concerné. Dans un autre chapitre, (Ch. 7) j’examine en détail l’expression de la négation dans les relatives. Après y avoir exposé les facteurs de variation spécifique à l’évolution de la négation, je propose une taxonomie fonctionnelle des constructions relatives négatives en néo-égyptien. Plus loin (Ch. 8), je me penche sur l’épineuse question de la valeur sémantique des relatives introduites par nty (« vraies » relatives) et de celles introduites par iw (relatives « virtuelles », c’est-à-dire des circonstancielles fonctionnant comme des relatives). Ma démarche, issue d’une réflexion critique à partir des études menées sur les différents types de relatives dans d’autres langues, m’amène à suggérer que, contrairement à ce qui a été dit pour l’égyptien ancien, leur distribution ne dépend pas uniquement de la définition de l’antécédent ou de la nature du relateur, mais que la valeur sémantique – contingente ou non – de la construction relativisée joue un rôle tout aussi important. Cette nouvelle façon d’aborder le problème permet d’apporter une explication quant à la grammaticalisation observée dans la distribution de ces constructions. L’avant dernier chapitre (Ch. 9) propose une étude approfondie de l’omission du pronom de rappel de l’antécédent dans les relatives du néo-égyptien. J’y recours aux concepts d’échelle d’accessibilité à la relativisation élaborée par Keenan & Comrie (1977), d’échelle d’accessibilité cognitive d’Ariel (1990) et aux travaux d’Hawkins (1999, 2004) relatifs à la structure informationnelle de la phrase complexe. Ce faisant, je définis des contextes particulièrement favorables à une omission, et démontre aussi que ces omissions sont en partie motivées par des facteurs extralinguistiques. Le dernier chapitre (Ch. 10) fait office de conclusion générale. Il fait le point sur l’apport des chapitres précédents et sur les différents types de variations mis en évidence dans cette étude. [less ▲]

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See detailLes problématiques de l'adaptation et de l'intersubjectivité dans la psychothérapie
Englebert, Jérôme ULg

Scientific conference (2017, May 10)

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See detailHunger Art and the Sensorium
Delville, Michel ULg

Conference (2017, May 10)

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See detailIdentification of non-stationary dynamical systems using multivariate ARMA models
Bertha, Mathieu ULg; Golinval, Jean-Claude ULg

in Mechanical Systems and Signal Processing (2017), 88

This paper is concerned by the modal identification of time-varying mechanical systems. Based on previous works about autoregressive moving average models in vector form (ARMAV) for the modal ... [more ▼]

This paper is concerned by the modal identification of time-varying mechanical systems. Based on previous works about autoregressive moving average models in vector form (ARMAV) for the modal identification of linear time invariant systems, and time-varying autoregressive moving average models (TV-ARMA) for the identification of nonstationary systems, a time-varying ARMAV (TV-ARMAV) model is presented for the multivariate identification of time-varying systems. It results in the identification of not only the time-varying poles of the system but also of its respective time-varying mode shapes. The method is applied on a time-varying structure composed of a beam on which a mass is moving. [less ▲]

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See detailIn vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review
Pestieau, Aude ULg; Evrard, Brigitte ULg

in European Journal of Pharmaceutical Sciences (2017), 102

For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at ... [more ▼]

For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at the absorption site and this can be challenging for compounds with low aqueous solubility such as BCS class II (low solubility, high permeability) and IV (low solubility, low permeability) compounds. If the development of oral delivery formulations of these compounds is frequently challenging to formulation scientists in the pharmaceutical industry, the in vitro evaluation of these new formulations is also a great challenge. One alternative approach to overcome the problems encountered with conventional dissolution methods is the use of biphasic dissolution systems. This review provides an overview of the origin and the evolution over time of the biphasic systems and the growing interest among scientists regarding their suitability for establishing in vitro-in vivo correlations. The evolution of these systems and their applications from the 1960s to the present day, such as in system variants and improvements, analysis of complex formulations, discriminatory power, bio-relevance, precipitation and supersaturation visualization, etc. will be discussed. [less ▲]

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See detailThe European Parliament as an actor in the global governance of culture: from voice to influence?
Vlassis, Antonios ULg

in Rioux, Michèle (Ed.) Culture, societies and digital technologies (2017)

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See detailFinite element model reduction for space thermal analysis
Jacques, Lionel ULg; Béchet, Eric ULg; Kerschen, Gaëtan ULg

in Finite Elements in Analysis and Design (2017), 127

To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on ... [more ▼]

To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on the clustering of a detailed mesh coming from a structural model for instance. The proposed method leads to a signi cant reduction of the number of radiative exchange factors (REFs) to compute and size of the corresponding matrix. It further keeps accurate conduction information by introducing the concept of physically meaningful super nodes. The REFs between the super nodes are computed through Monte Carlo ray-tracing on the partitioned mesh, preserving the versatility of the method. The resulting conductive-radiative reduced model is solved using standard iterative techniques and the detailed mesh temperatures can be recovered from the super nodes temperatures for further thermo-mechanical analysis. The proposed method is applied to a structural component of the Meteosat Third Generation mission and is benchmarked against ESATAN-TMS, the standard thermal analysis software used in the European aerospace industry. [less ▲]

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See detailProcess intensification of the synthesis of glycerol carbonate under microwave irradiation or continuous-flow conditions
Estager, Julien; Pleck, Julie; Gerardy, Romaric ULg et al

Conference (2017, May)

Despite low crude oil prices and the increasing access to shale gas, the establishment of a biobased economy remains a worldwide priority. An integrated biobased economy would not only consider renewable ... [more ▼]

Despite low crude oil prices and the increasing access to shale gas, the establishment of a biobased economy remains a worldwide priority. An integrated biobased economy would not only consider renewable biobased resources to provide industrially relevant chemicals, but would also redefine chemical processing by using greener, safer and more selective process technologies. The last few decades have witnessed the emergence of promising alternative energy sources such as microwave irradiation and alternative process technology such as continuous-flow reactors. Even if biobased chemicals are still marginal on the marklet compared to petrochemicals, many biorefineries are now able to convert biomass into biobased chemical building blocks of good purity on large scales. Amongst these products, glycerol – a side product of the biodiesel industry – is a particularly appealing chemical platform thanks to its high functionality and its wide availability. Various high-value added chemicals can be obtained from glycerol, among which glycerol carbonate retained our attention. Glycerol carbonate is an attractive glycerol derivative that can be used in many applications ranging from low-VOC solvent to polymer synthesis. Many publications describe its synthesis using different catalysts or alternative activation methods such as microwave. Our research effort in process intensification for the industrial valorization of biomass led us to develop an intensified carbonation process of glycerol under microwave irradiation, affording an unprecedented reactivity with short reaction times and high selectivity towards glycerol carbonate. Based on this preliminary study, and using the microwave-to-flow paradigm, continuous-flow processes using mesofluidic reactors have been developed to obtain glycerol carbonate in good yield and high purity. [less ▲]

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See detailSilica or Coal ? Design and Implementation of Dust Prevention in the Collieries in Western Economies, ca. 1930-1980
Geerkens, Eric ULg

in Rosental, Paul-André (Ed.) Silicosis. A World History (2017)

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See detailDiscovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry
Echterbille, Julien; Gilles, Nicolas; Araoz, Romulo et al

in Toxicon (2017), 130

Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α ... [more ▼]

Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α-conotoxins, a family of peptide toxins produced by venomous cone snails. nAChRs are implicated in numerous physiological processes explaining why the design of new pharmacological tools and the discovery of potential innovative drugs targeting these receptor channels appear so important. This work describes a methodology developed to discover new ligands of nAChRs from complex mixtures of peptides. The methodology was set up by the incubation of Torpedo marmorata electrocyte membranes rich in nAChRs with BSA tryptic digests (>100 peptides) doped by small amounts of known nAChRs ligands (α-conotoxins). Peptides that bind to the receptors were purified and analyzed by MALDI-TOF/TOF mass spectrometry which revealed an enrichment of α-conotoxins in membrane-containing fractions. This result exhibits the binding of α-conotoxins to nAChRs. Negative controls were performed to demonstrate the specificity of the binding. The usefulness and the power of the methodology were also investigated for a discovery issue. The workflow was then applied to the screening of Conus ermineus crude venom, aiming at characterizing new nAChRs ligands from this venom, which has not been extensively investigated to date. The methodology validated our experiments by allowing us to bind two α-conotoxins (α-EI and α-EIIA) which have already been described as nAChRs ligands. Moreover, a new conotoxin, never described to date, was also captured, identified and sequenced from this venom. Classical pharmacology tests by radioligand binding using a synthetic homologue of the toxin confirm the activity of the new peptide, called α-EIIB. The Ki value of this peptide for Torpedo nicotinic receptors was measured at 2.2 ± 0.7 nM. [less ▲]

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See detailEvaluation of the implementation of integrated care for people with chronic conditions
Van Durme, Thérèse; Anthierens, Sibyl; Van Hecke, Ann et al

Conference (2017, May)

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See detailDiversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four Conus species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformatics
Degueldre, Michel; Verdenaud, Marion; Garikoitz, Legarda et al

in Toxicon (2017), 130

Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top ... [more ▼]

Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top candidates for the development of innovative drugs. Instead of relying on the classical, low-throughput bioassay-guided approach to identify innovative bioactive peptides, this work exploits a recent paradigm to access to venom diversity. This strategy bypasses the classical approach by combining high-throughput transcriptomics, proteomics and bioinformatics cutting-edge technologies to generate reliable peptide sequences. The strategy employed to generate hundreds of reliable sequences from Conus venoms is deeply described. The study led to the discovery of (i) conotoxins that belong to known pharmacological families targeting various GPCRs or ion-gated channels, and (ii) new families of conotoxins, never described to date. It also focusses on the diversity of genes, sequences, folds, and PTM's provided by such species. [less ▲]

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