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See detailNon-adiabatic study of the Kepler subgiant KIC 6442183
Grosjean, Mathieu ULg; Dupret, Marc-Antoine ULg; Belkacem, Kevin et al

in The Space Photometry Revolution CoRoT Symposium 3, Kepler KASC-7 joint meeting (in press)

Thanks to the precision of Kepler observations, [3] were able to measure the linewidth and amplitude of individual modes (including mixed modes) in several sub- giant power spectra. We perform a forward ... [more ▼]

Thanks to the precision of Kepler observations, [3] were able to measure the linewidth and amplitude of individual modes (including mixed modes) in several sub- giant power spectra. We perform a forward modelling of a Kepler subgiant based on sur- face properties and observed frequencies. Non-adiabatic computations including a time- dependent treatment of convection give the lifetimes of radial and non-radial modes. Next, combining the lifetimes and inertias with a stochastic excitation model gives the ampli- tudes of the modes. We can now directly compare theoretical and observed linewidths and amplitudes of mixed-modes to obtain new constraints on our theoretical models. [less ▲]

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See detailEfficacy and safety of currently marketed anti-osteoporosis medications
Reginster, Jean-Yves ULg; NEUPREZ, Audrey ULg; Dardenne, Nadia ULg et al

in Best Practice & Research. Clinical Endocrinology & Metabolism (in press)

During the past 2 decades, many interventions were proven effective in the management of postmenopausal osteoporosis. The objective of an anti-osteoporosis treatment is to reduce fracture rates, ideally ... [more ▼]

During the past 2 decades, many interventions were proven effective in the management of postmenopausal osteoporosis. The objective of an anti-osteoporosis treatment is to reduce fracture rates, ideally at all skeletal sites (i.e. spine, hip, and other non-spine). The armamentarium against osteoporosis includes anti-resorptive agents (i.e. bisphosphonates, selective estrogen receptor modulators and denosumab), bone-forming agents (i.e. peptides from the parathyroid hormone family) and one agent with a dual mechanism of action (i.e. strontium ranelate). All these medications combine anti-fracture efficacy with a reasonable benefit/risk profile. However, the choice of a particular chemical entity, in one individual patient is based on the knowledge and expertise of the physician. Prioritization of drugs should be based on the individual profile of the patient, the severity of osteoporosis and the specific contraindications, warnings and precautions of use of the various available medications. [less ▲]

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See detailDramatic osteonecrosis of the jaw associated with oral bisphosphonates, periodontitis and dental implant removal
Ayora, A F; HERION, Francine ULg; ROMPEN, Eric ULg et al

in Journal of Clinical Periodontology (in press)

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these ... [more ▼]

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these medications, osteonecrosis of the jaw is a significant complication in a subset of patients receiving these drugs. CASE PRESENTATION: This report documents a case of dramatic bisphosphonate-related osteonecrosis associated with periodontitis and dental implant removal in an osteoporotic patient treated with per os bisphosphonates for an uninterrupted period of 15 years. CONCLUSION: The aim of this report was to discuss the administration period of BP in the treatment of osteoporosis, the decision-making and clinical management of severe MRONJ and the indications for dental implant placement in these specific patients. [less ▲]

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See detailBrief exposure of embryos to steroids or aromatase inhibitor induces sex reversal in Nile tilapia (Oreochromis niloticus)
Gennotte, Vincent ULg; Mafwila Kinkela, Patrick; Ulysse, Bernard et al

in Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology (in press)

This study aimed to develop sex reversal procedures targeting the embryonic period as tools to study the early steps of sex differentiation in Nile tilapia with XX, XY and YY sexual genotypes. XX eggs ... [more ▼]

This study aimed to develop sex reversal procedures targeting the embryonic period as tools to study the early steps of sex differentiation in Nile tilapia with XX, XY and YY sexual genotypes. XX eggs were exposed to masculinizing treatments with androgens (17α-methyltestosterone, 11-ketotestosterone) or aromatase inhibitor (Fadrozole), whereas XY and YY eggs were subjected to feminizing treatments with estrogen analog (17α-ethynylestradiol). All treatments consisted of a single or double 4-h immersion applied between 1 and 36 h post-fertilization (hpf). Concentrations of active substances were 1000 or 2000 µg l-1 in XX and XY, and 2000 or 6500 µg l-1 in YY. Masculinizing treatments of XX embryos achieved a maximal sex reversal rate of 10 % with an exposure at 24 hpf to 1000 µg l-1 of 11-ketotestosterone or to 2000 µg l-1 of Fadrozole. Feminization of XY embryos was more efficient and induced up to 91 % sex reversal with an exposure to 2000 µg l-1 of 17α-ethynylestradiol. Interestingly, similar treatments failed to reverse YY fish to females, suggesting either that a sex determinant linked to the Y chromosome prevents the female pathway when present in two copies, or that a gene present on the X chromosome is needed for the development of a female phenotype. [less ▲]

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See detailPolysaccharide-coated PCL nanofibers for wound dressing applications
Croisier, Florence ULg; Atanasova, Ganka; Poumay, Yves et al

in Advanced Healthcare Materials (in press)

Polysaccharide-based nanofibers with amultilayered structure are prepared by combining electrospinning (ESP) and layer-by-layer (LBL) deposition techniques. Charged nanofibers are firstly prepared by ... [more ▼]

Polysaccharide-based nanofibers with amultilayered structure are prepared by combining electrospinning (ESP) and layer-by-layer (LBL) deposition techniques. Charged nanofibers are firstly prepared by electrospinning poly(ε-caprolactone) (PCL) with a block-copolymer bearing carboxylic acid functions. After deprotonation of the acid groups, the layer-by-layer deposition of polyelectrolyte polysaccharides, notably chitosan and hyaluronic acid, is used to coat the electrospun fibers. A multilayered structure is achieved by alternating the deposition of the positively charged chitosan with the deposition of a negatively charged polyelectrolyte. The construction of this multi-layered structure is followed by Zeta potential measurements, and confirmed by observation of hollow nanofibers resulting from the dissolution of the PCL core in a selective solvent. These novel polysaccharide-coated PCL fiber mats remarkably combine the mechanical resistance typical of the core material (PCL) – particularly in the hydrated state –, with the surface properties of chitosan. The control of the nanofiber structure offered by the electrospinning technology, makes the developed process very promising to precisely design biomaterials for tissue engineering. Preliminary cell culture tests corroborate the potential use of such system in wound healing applications. [less ▲]

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See detailThe sensitive period for male to female sex reversal begins at the embryonic stage in the Nile tilapia and is associated with the sexual genotype
Gennotte, Vincent ULg; Mélard, Charles ULg; D'Cotta, Helena et al

in Molecular Reproduction and Development (in press)

In this study, we applied feminization treatments of 4 h on XY (17α-ethynylestradiol 2000 µg l-1) and YY (6500 µg l-1) Nile tilapia embryos on the first dpf. The mechanism of early sex reversal was ... [more ▼]

In this study, we applied feminization treatments of 4 h on XY (17α-ethynylestradiol 2000 µg l-1) and YY (6500 µg l-1) Nile tilapia embryos on the first dpf. The mechanism of early sex reversal was investigated by searching for changes in the expression profiles of some sex-differentiating genes in the brain (cyp19a1b, foxl2 and amh) and in sexual steroids (testosterone, 17β-estradiol and 11-ketotestosterone) concentrations during embryogenesis and gonad differentiation. No sex reversal was observed in YY but sex reversal rates in XY progenies ranged from 0 to 60 %. These results, together with the clearance profile of 17α-ethynylestradiol confirmed the existence of an early sensitive period for sex determination encompassing embryonic and larval development, prior to any sign of gonad differentiation. The estrogen treatment induced an increased expression of cyp19a1b and a higher level of testosterone and 17β-estradiol at 4 dpf in XY and YY. Foxl2 and amh were repressed at 4 dpf and expression levels were not different between treated and control groups at 14 dpf suggesting that foxl2 did not control cyp19a1b in the brain of tilapia embryos. Increased cyp19a1b expression in treated embryos could reflect a sign of early brain sexualization but alone cannot account for the sex reversal effect as the treatment was ineffective in YY. The differential sensitivity of XY and YY genotypes to embryo induced-feminization suggests that a sex determinant on the sex chromosomes, either a Y repressor or an X activator may influence the sex reversal during the first steps of tilapia embryogenesis. [less ▲]

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See detailExperimental and numerical study of the flight of geese
Dimitriadis, Grigorios ULg; Gardiner, James; Tickle, Peter et al

in Aeronautical Journal (in press)

The flight of barnacle geese at airspeeds representing high-speed migrating flight is investigated using experiments and simulations. The experimental part of the work involved the filming of three ... [more ▼]

The flight of barnacle geese at airspeeds representing high-speed migrating flight is investigated using experiments and simulations. The experimental part of the work involved the filming of three barnacle geese (Branta Leucopsis) flying at different airspeeds in a wind tunnel. The video footage was analysed in order to extract the wing kinematics. Additional information, such as wing geometry and camber was obtained from a 3D scan of a dried wing. An unsteady vortex lattice method was used to simulate the aerodynamics of the measured flapping motion. The simulations were used in order to successfully reproduce the measured body motion and thus obtain estimates of the aerodynamic forces acting on the wings. It was found that the mean of the wing pitch angle variation with time has the most significant effect on lift while the difference in the durations of the upstroke and downstroke has the major effect on thrust. The power consumed by the aerodynamic forces was also estimated; it was found that increases in aerodynamic power correspond very closely to climbing motion and vice versa. Root-mean-square values of the power range from 100 W to 240 W. Finally, it was observed that tandem flying can be very expensive for the trailing bird. [less ▲]

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See detailPersonnalité antisociale et psychopathologie
Englebert, Jérôme ULg

Conference (2015, July 14)

Notre communication a pour objectif de confronter les critères de la personnalité antisociale du DSM-IV et du DSM-5 à une réflexion psychopathologique. Nous commencerons par une analyse des différentes ... [more ▼]

Notre communication a pour objectif de confronter les critères de la personnalité antisociale du DSM-IV et du DSM-5 à une réflexion psychopathologique. Nous commencerons par une analyse des différentes contradictions propres au diagnostic qui nous mèneront à l’identification du critère « primaire » de cette entité qui est l’« incapacité à se conformer aux lois et normes sociales ». Nous confronterons ensuite à des situations cliniques l’hétérogénéité des profils pouvant répondre à ce diagnostic. Nos constats nous conduiront à mettre en doute la validité apparente du concept de personnalité antisociale, puisqu’il recouvre des modes de fonctionnement psychologique variés. La valeur discriminative faible, en matière de fonctionnement psychologique, suggère que c’est une dimension autre que psychopathologique qui organise ce diagnostic. Dénuée de toute attention pour les modes d’interactions, pour le vécu émotionnel et pour les états de subjectivité, la notion de personnalité antisociale ne porte pas d’intérêt à l’individu qu’elle catégorise, mais bien à l’acte délinquant commis par ce dernier. Nous conclurons sur le constat de l’absence de dimension psychopathologique de la personnalité antisociale, qui se révèle être un diagnostic principalement criminologique, à l’inverse des fondements de l’éthique psychopathologique. [less ▲]

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See detailSemiótica de la acción: textualización y notación
Dondero, Maria Giulia ULg

in Tópicos del seminario (2015), 31

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining ... [more ▼]

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining the forms of enunciative praxis through different levels of pertinence analysis. Secondly, we propose the concept of ‘textualization’ as a mediation between text and action: textualizations (photographs, videos, notes) organize and represent practices which are in themselves ephemeral and elusive. Finally, we will consider the textual diagrammatization that we call ‘notation’: this analytical form of mediation between text and practice does not have the same status of in-vivo textualisations, but it works like an ex-post reconstruction which highlights the main gestures and exchanges while performing their grammaticalization. A more general aim of this essay is an enquiry into the legitimate objects of textual semiotics: what are the objects that it can analyze without betraying its principle of immanence, but also without being confined to it and, as a consequence, being unable to analyze practices and respond to topical questions on social issues and on the research in the human sciences? [less ▲]

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See detailSubjectivations politiques et épreuve de soi. Le cas Sartre/Fanon
Cormann, Grégory ULg

Scientific conference (2015, March 05)

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See detailLes Grecs ont-ils étudié le latin ?
Rochette, Bruno ULg

Scientific conference (2015, February 19)

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See detailQuand la clinique bouscule les concepts
Englebert, Jérôme ULg

Scientific conference (2015, February 11)

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See detailEffects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis
Preud'Homme, Valérie; Milla, Sylvain; Gillardin, Virginie et al

in Chemosphere (2015), 120(2), 357-364

Understanding the impact of pesticides in amphibians is of growing concern to assess the causes of their decline. Among pesticides, endosulfan belongs to one of the potential sources of danger because of ... [more ▼]

Understanding the impact of pesticides in amphibians is of growing concern to assess the causes of their decline. Among pesticides, endosulfan belongs to one of the potential sources of danger because of its wide use and known effects, particularly neurotoxic, on a variety of organisms. However, the effect of endosulfan was not yet evaluated on amphibians at levels encompassing simultaneously brain neurotransmitters and behavioural endpoints. In this context, tadpoles of the African clawed frog Xenopus laevis were submitted to four treatments during 27 d: one control, one ethanol control, and two low environmental concentrations of endosulfan (0.1 and 1 μg L−1). Endosulfan induced a significant increase of brain serotonin level at both concentrations and a significant increase of brain dopamine and GABA levels at the lower exposure but acetylcholinesterase activity was not modified by the treatment. The gene coding for the GABA transporter 1 was up-regulated in endosulfan contaminated tadpoles while the expression of other genes coding for the neurotransmitter receptors or for the enzymes involved in their metabolic pathways was not significantly modified by endosulfan exposure. Endosulfan also affected foraging, and locomotion in links with the results of the physiological assays, but no effects were seen on growth. These results show that low environmental concentrations of endosulfan can induce adverse responses in X. laevis tadpoles. At a broader perspective, this suggests that more research using and linking multiple markers should be used to understand the complex mode of action of pollutants. [less ▲]

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See detailAntoine Galland et l'épigraphie
Famerie, Etienne ULg

in Bauden, Frédéric; Waller, Richard (Eds.) Colloque international A. Galland (2015, February)

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See detailLa démocratie sous expertise. Médias, think tanks et privatisation du débat européen (en préparation, parution début 2015)
Geuens, Geoffrey ULg

Book published by Éditions du Croquant, collection "Savoir / Agir" (2015)

L’ouvrage questionne la genèse des think tanks eurofédéralistes participant à la fabrication et à la légitimation des politiques d’intégration, avant de s’intéresser à ces autres agents sociaux de ... [more ▼]

L’ouvrage questionne la genèse des think tanks eurofédéralistes participant à la fabrication et à la légitimation des politiques d’intégration, avant de s’intéresser à ces autres agents sociaux de production et de diffusion de la pensée européenne que sont notamment les correspondants bruxellois et éditorialistes de quelques grands médias européens. L’ouvrage montre combien le discours journalistique sur l’Europe et le discours de certains « spécialistes » des questions européennes, qui trouve aussi à s’exprimer dans l’espace médiatique, sont la plupart du temps limités à quelques expressions stéréotypées et argumentaires clichés s’expliquant autant par la position occupée dans le champ du pouvoir par les agents qui s’en font les relais que par les dispositions de ces mêmes agents sociaux à l’égard du « projet européen ». [less ▲]

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See detailEffect of stress path on the miniaturizatio size effect for nickel polycrystals
Keller, Clement; Hug, Eric; Duchene, Laurent ULg et al

Conference (2015, January 04)

The mechanical behavior of mettalic materials deeply depends on the size of samples. For specimen dimensions de creasing from a few millimeters to a few micrometers, the general observed trend is a ... [more ▼]

The mechanical behavior of mettalic materials deeply depends on the size of samples. For specimen dimensions de creasing from a few millimeters to a few micrometers, the general observed trend is a softening of the mechanical behavior in tension which affects the stress level and the strain hardening. This effect is triggered by the derease of the number of grains across the thickness ( also called thickness"t" over grain size "d" ratio). The objective of this work is to provide new experimental results in order to analyse the miniaturization size effects for various stress paths without strain gradients across the thickness of the samples. To this aim, experimental tensil tests, large tensile tests and shear tests have been performed on Ni sheets ( 0.5mm) with various grain sizes ensuring different t/d ratios. Results show that the miniaturization softening is affected by triaxiality, the larger is this parameter, the lower is the mechanicval softening. These features seem to be linked to surface effects which are larger for low triaxiality stress paths. Attempts of numerical simulations using strain gradient crystal plasticity model are also performed to confirm the role played by surface effects. [less ▲]

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See detailA new species of Groenlandaspis Heintz, 1932 (Placodermi, Arthrodira) from the Famennian (Late Devonian) of Belgium
Olive, Sébastien ULg; Prestianni, Cyrille; Dupret, Vincent

in Journal of Vertebrate Paleontology (2015), 35(5),

A new species of the phlyctaeniid arthrodire genus Groenlandaspis from the upper Famennian of Belgium is described. The remains of Groenlandaspis potyi sp. nov. consist of dissociated thoracic armor ... [more ▼]

A new species of the phlyctaeniid arthrodire genus Groenlandaspis from the upper Famennian of Belgium is described. The remains of Groenlandaspis potyi sp. nov. consist of dissociated thoracic armor elements, but the specimen designed to be the holotype displays the median dorsal, anterior and posterior dorsolateral plates in connection. Though incomplete, the new species is characterized by an equilateral triangle-shaped median dorsal plate, a protruding posterodorsal apron of the posterior dorsolateral plate behind the overlap area for the median dorsal plate, and an overall lack of ornamentation. Groenlandaspis potyi sp. nov. constitutes the second occurrence of a Groenlandaspis species in continental Europe after the description of Groenlandaspis thorezi from upper Famennian quarries of Belgium. Another probable new species of Groenlandaspis is also described, though of unknown locality and horizon; it can however be deduced from the upper Famennian of Belgium without more precision. Together with some unpublished material of groenlandaspidids from the Famennian tetrapod-bearing locality of Strud, this material highlights the richness of the Groenlandaspididae diversity in Belgium. The discovery of Groenlandaspis potyi sp. nov. in Belgium reinforces the Famennian global distribution of this widespread genus during this period. Also, since those organisms have possibly been considered as non-marine indicators, this material is another argument pleading for close relationships between Euramerica and Gondwana around the Frasnian-Famennian boundary. [less ▲]

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See detailElsvier, Computers in Industry, Special Issue on Natural Language Processing and Text Analytics in Industry
Ittoo, Ashwin ULg; Bosh, v.d., Antal; Nguyen, Le Minh

Book published by Elsevier (2015)

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See detail"Des muets qui veulent parler". Lectures politiques, des Temps Modernes à L'Idiot de la famille
Cormann, Grégory ULg

in Bolmain, Thomas; Cormann, Grégory (Eds.) Politiques de la littérature. Bourdieu, Sartre, Foucault (2015)

Detailed reference viewed: 25 (2 ULg)