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See detailQuality of life and physical components linked to sarcopenia: The SarcoPhAge study.
Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg; Petermans, Jean ULg et al

in Experimental gerontology (in press)

INTRODUCTION: The SarcoPhAge project is an ongoing longitudinal study following community-dwelling elderly subjects with the objective to assess some health and functional consequences of sarcopenia. The ... [more ▼]

INTRODUCTION: The SarcoPhAge project is an ongoing longitudinal study following community-dwelling elderly subjects with the objective to assess some health and functional consequences of sarcopenia. The sarcopenia diagnosis algorithm developed by the European Working Group on Sarcopenia in Older People (EWGSOP) and used in the present study needs further validation through cross-sectional and longitudinal studies. The aim of the present study is to assess, using this algorithm, the prevalence of sarcopenia and the clinical components linked to this geriatric syndrome. METHODS: Participants were community dwelling subjects aged 65years or older. To diagnose sarcopenia, we applied the definition of the EWGSOP. Muscle mass was measured by dual-energy X-ray absorptiometry, muscle strength by a hydraulic dynamometer and physical performance by the SPPB test. Large amounts of socio-demographic, anamnestic and clinical data were collected in all subjects. RESULTS OVER ONE YEAR: 534 subjects were recruited for this study (60.5% of women, mean age of 73.5+/-6.16years), among whom 73 subjects were diagnosed sarcopenic, which represents a global prevalence of 13.7%. Prevalence was 11.8% in men and 14.9% in women. Sarcopenic subjects were older; had a lower Body Mass Index, lower calf, waist, wrist and arm circumferences; presented more cognitive impairments (Mini-Mental State Examination), more comorbidities; were more often malnourished; and consumed more drugs. After adjustment for age, BMI, cognitive status, nutritional status, number of comorbidities and number of drugs, sarcopenic subjects had a worse physical health-related quality of life (SF-36) for the domain of physical functioning, were at higher risk of falls (Timed Up and Go test), were more frail (Fried), presented more often tiredness for the achievement of activities of daily living (Mobility-test), presented less fat mass and obviously less lean mass. Sarcopenic women were also more dependent for housekeeping and handling finances (Lawton scale) than non-sarcopenic ones. CONCLUSION: Sarcopenia seems to be associated with many harmful clinical components making this geriatric syndrome a real public health burden. Follow-up data of the SarcoPhAge study will be helpful to assess the outcomes of sarcopenia based on the EWGSOP diagnosis algorithm and its different proposed cut-offs. [less ▲]

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See detailTowards a framework for assessment and management of cumulative human impacts on marine food webs
Giakoumi, Sylvaine; Halpern, Benjamin S.; Michel, Loïc ULg et al

in Conservation Biology (in press)

Effective ecosystem-based management requires understanding ecosystem responses to multiple human threats, rather than focusing on single threats. To understand ecosystem responses to anthropogenic ... [more ▼]

Effective ecosystem-based management requires understanding ecosystem responses to multiple human threats, rather than focusing on single threats. To understand ecosystem responses to anthropogenic threats holistically, it is necessary to know how threats affect different components within ecosystems and ultimately alter ecosystem functioning. We used a case study of a Mediterranean seagrass (Posidonia oceanica) food web and expert knowledge elicitation in an application of the initial steps of a framework for assessment of cumulative human impacts on food webs. We produced a conceptual seagrass food web model, determined the main trophic relationships, identified the main threats to the food web components, and assessed the components’ vulnerability to those threats. Some threats had high (e.g., coastal infrastructure) or low impacts (e.g., agricultural runoff) on all food web components, whereas others (e.g., introduced carnivores) had very different impacts on each component. Partitioning the ecosystem into its components enabled us to identify threats previously overlooked and to reevaluate the importance of threats commonly perceived as major. By incorporating this understanding of system vulnerability with data on changes in the state of each threat (e.g., decreasing domestic pollution and increasing fishing) into a food web model, managers may be better able to estimate and predict cumulative human impacts on ecosystems and to prioritize conservation actions. [less ▲]

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See detailTrabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice.
Harvey, N. C.; Gluer, C. C.; Binkley, N. et al

in Bone (in press)

Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures ... [more ▼]

Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and clinical risk factors in osteoporosis risk stratification, it must be independently associated with fracture risk, readily obtainable, and ideally, present a risk which is amenable to osteoporosis treatment. This paper summarizes a review of the scientific literature performed by a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis. Low TBS is consistently associated with an increase in both prevalent and incident fractures that is partly independent of both clinical risk factors and areal BMD (aBMD) at the lumbar spine and proximal femur. More recently, TBS has been shown to have predictive value for fracture independent of fracture probabilities using the FRAX(R) algorithm. Although TBS changes with osteoporosis treatment, the magnitude is less than that of aBMD of the spine, and it is not clear how change in TBS relates to fracture risk reduction. TBS may also have a role in the assessment of fracture risk in some causes of secondary osteoporosis (e.g. diabetes, hyperparathyroidism and glucocorticoid-induced osteoporosis). In conclusion, there is a role for TBS in fracture risk assessment in combination with both aBMD and FRAX. [less ▲]

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See detailLe Mur et le masque. À propos de Banksy.
Saint-Amand, Denis ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

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See detailÀ propos de l’écologie du discours heuristique
Job, Pierre ULg; Gilot, Marguerite ULg

in Actes du 4ième congrès international sur la théorie anthropologique du didactique (TAD) : Évolutions contemporaines du rapport aux mathématiques et aux autres savoirs à l'école et dans la société (in press)

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See detailInventer. Le jeune Descartes et les voies de l’inventio en 1619-1620
Dubouclez, Olivier ULg

in Savini, Massimiliano (Ed.) Les écrits de jeunesse de Descartes (in press)

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See detailImaginer-lire le Capital
Pieron, Julien ULg

in Cahiers d'Etudes Germaniques (in press)

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See detailDialectique de l’inattendu. Voies et impasses de la philosophie dans l’œuvre de Valère Novarina
Dubouclez, Olivier ULg

in Née, Laure (Ed.) Valère Novarina (in press)

Novarina entretient avec la philosophie une relation faite d’attraction et de défiance. Le primat accordé à la parole et le refus de toute ontologie le conduisent à définir un nouveau modèle théorique ... [more ▼]

Novarina entretient avec la philosophie une relation faite d’attraction et de défiance. Le primat accordé à la parole et le refus de toute ontologie le conduisent à définir un nouveau modèle théorique, celui de la « fugue » et, tout en poursuivant le dialogue avec les philosophes, à construire ce que nous appellerons une dialectique de l’inattendu, mouvement par lequel le vide actif qui habite la personne humaine nourrit le renouvellement de la pensée et de l’action. [less ▲]

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See detailSartre em psicologia clínica: situação, emoção e ultrapassando
Englebert, Jérôme ULg

in Ribeiro Scheider, Daniela; Gastal de Castro, Fernando; Bloc Boris, Georges (Eds.) Sartre e os desafios para a psicologia contemporânea (in press)

À travers ce chapitre, nous proposons de réaliser l’étude de différents apports de la philosophie de Jean-Paul Sartre à la réflexion et la pratique de la psychopathologie. La « psychopathologie de l’homme ... [more ▼]

À travers ce chapitre, nous proposons de réaliser l’étude de différents apports de la philosophie de Jean-Paul Sartre à la réflexion et la pratique de la psychopathologie. La « psychopathologie de l’homme en situation » qui s’esquisse repose sur la notion fondamentale de l’émotion ainsi que sur la possibilité de dépassement de cette situation. Ce moment fait jaillir une trame temporelle puisqu’il révèle à la fois l’histoire et la biographie du sujet, mais également son projet et dès lors les fulgurances de la liberté. Penser l’homme en situation, le savoir sorcier ou magicien (c’est-à-dire à la fois ému et émouvant) et parvenir à mobiliser sa narrativité sont des paris essentiels de l’œuvre de Sartre, que la psychopathologie, tant dans sa dimension théorique que pratique, ne peut ignorer. [less ▲]

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See detailHommage à Luc Collès
Defays, Jean-Marc ULg; Géron, Geneviève

Book published by Editions Modulaires Européennes (in press)

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See detailQu'est-ce qu'un indicateur ? Paradigme indiciaire et processus de gouvernementalité
Petteni, Oriane ULg

in Nicolas, Loic (Ed.) L'indice (in press)

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See detailL’utilisation du facteur de Bayes pour identifier les étudiants qui répondent au hasard
Béland, Sébastien; Raîche, Gilles; Magis, David ULg

in Revue des Sciences de l'Education (in press)

Les méthodes permettant de détecter les réponses au hasard dans l’évaluation des apprentissages présentent quelques limites. Par exemple, les indices de détection de patrons de réponses inappropriés ... [more ▼]

Les méthodes permettant de détecter les réponses au hasard dans l’évaluation des apprentissages présentent quelques limites. Par exemple, les indices de détection de patrons de réponses inappropriés (person-fit indexes) nécessitent généralement de grandes bases de données et permettent seulement de dire si un étudiant répond en accord ou non avec un modèle de mesure (par exemple, le modèle de Rasch). Dans le cadre de cet article, nous présentons une nouvelle approche permettant d’identifier les étudiants qui répondent au hasard lors d'épreuves d'évaluation des apprentissages. Après avoir discuté des limites des principales approches existantes, nous exposons les détails techniques de l'utilisation du facteur de Bayes pour évaluer un nombre fini d'hypothèses informatives. Ensuite, nous appliquons le facteur de Bayes à des données simulées et des données réelles obtenues à des fins d’illustration. Les résultats permettent de voir que le facteur de Bayes est une méthode prometteuse pour détecter le comportement de réponse au hasard. [less ▲]

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See detailWhat do Pneumocystis organisms tell us about the phylogeography of their hosts? The case of the woodmouse Apodemus sylvaticus in continental Europe and western Mediterranean islands
Demanche, christine; Deville, Manjula; Michaux, Johan ULg et al

in PLoS ONE (in press)

Pneumocystis fungi represent a highly diversified biological group with numerous species, which display a strong host-specificity suggesting a long co-speciation process. In the present study, the ... [more ▼]

Pneumocystis fungi represent a highly diversified biological group with numerous species, which display a strong host-specificity suggesting a long co-speciation process. In the present study, the presence and genetic diversity of Pneumocystis organisms was investigated in 203 lung samples from woodmice (Apodemus sylvaticus) collected on western continental Europe and Mediterranean islands. The presence of Pneumocystis DNA was assessed by nested PCR at both large and small mitochondrial subunit (mtLSU and mtSSU) rRNA loci. Direct sequencing of nested PCR products demonstrated a very high variability among woodmouse-derived Pneumocystis organisms with a total number of 30 distinct combined mtLSU and mtSSU sequence types. However, the genetic divergence among these sequence types was very low (up to 3.87%) and the presence of several Pneumocystis species within Apodemus sylvaticus was considered unlikely. The analysis of the genetic structure of woodmouse-derived Pneumocystis revealed two distinct groups. The first one comprised Pneumocystis from woodmice collected in continental Spain, France and Balearic islands. The second one included Pneumocystis from woodmice collected in continental Italy, Corsica and Sicily. These two genetic groups were in accordance with the two lineages currently described within the host species Apodemus sylvaticus. Pneumocystis organisms are emerging as powerful tools for phylogeographic studies in mammals [less ▲]

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See detailContribution of Revised International Prognostic Scoring System Cytogenetics to Predict Outcome After Allogeneic Stem Cell Transplantation for Myelodysplastic Syndromes: A Study From the Socie 0 te0 FranO´ aise de Greffe de Moelle et The 0 rapies Cellulaires
Gauthier, Jordan; Damaj, Gandhi; Langlois, Carole et al

in Transplantation (in press)

Background. The prognosis of myelodysplastic syndromes (MDS) after allogeneic stem cell transplantation is critically determined by cytogenetic abnormalities, as previously defined by International ... [more ▼]

Background. The prognosis of myelodysplastic syndromes (MDS) after allogeneic stem cell transplantation is critically determined by cytogenetic abnormalities, as previously defined by International Prognostic Scoring System (IPSS) cytogenetics. It has been shown that a new cytogenetic classification, included in the IPSS-R (cytogenetic-IPSS-R [C-IPSS-R]), can better predict the outcome of untreated MDS patients.Methods. In this study, we assessed the impact of the IPSS-R cytogenetic score (C-IPSS-R) on the outcome of 367 MDS patients transplanted from HLA-identical siblings or HLA allele-matched unrelated donors. Results. According to the C-IPSS-R, 178 patients (48%) fell in the good risk, 102 (28%) in the intermediate risk, 77 (21%) in the poor risk, and 10 (3%) in the very poor risk group. In multivariate analysis, after a median follow-up of 4 years, the poor and very poor-risk categories correlated with shorter overall survival (OS) (4-year OS, 32%; hazard ratio [HR], 1.59; P = 0.009 and OS, 10%; HR, 3.18; P = 0.002, respectively) and higher cumulative incidence of relapse (CIR) (CIR, 52%; HR, 1.82; P = 0.004 and CIR, 60%; HR, 2.44; P = 0.060, respectively). Conclusions. Overall, the C-IPSS-R changed the IPSS cytogenetic risk only in 8% of cases but identified a new risk group, the very poor C-IPSS-R category, with dismal outcome after allogeneic stem cell transplantation (10% 4-year OS, 60% 4-year CIR). Posttransplantation maintenance therapy should be investigated in prospective trials for patients with high-risk C-IPSS-R karyotypes. [less ▲]

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See detailInfluence of process operating conditions on solvent thermal and oxidative degradation in post-combustion CO2 capture
Léonard, Grégoire ULg; Crosset, Cyril; Toye, Dominique ULg et al

in Computers & Chemical Engineering (in press)

The CO2 post-combustion capture with amine solvents is modeled as a complex system interconnecting process energy consumption and solvent degradation and emission. Based on own experimental data ... [more ▼]

The CO2 post-combustion capture with amine solvents is modeled as a complex system interconnecting process energy consumption and solvent degradation and emission. Based on own experimental data, monoethanolamine degradation is included into a CO2 capture process model. The influence of operating conditions on solvent loss is validated with pilot plant data from literature. Predicted solvent consumption rates are in better agreement with plant data than any previous work, and pathways are discussed to further refine the model. Oxidative degradation in the absorber is the largest cause of solvent loss while thermal degradation does not appear as a major concern. Using a single model, the process exergy requirement decreases by 10.8% and the solvent loss by 11.1% compared to our base case. As a result, this model provides a practical tool to simultaneously minimize the process energy requirement and the solvent consumption in post-combustion CO2 capture plants with amine solvents. [less ▲]

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See detailRéflexivité et classes sémantiques dans le lexique verbal français
Mazziotta, Nicolas ULg; Stein, Achim

in XXXIII. Tagung des Deutschen Romanistenverbands (DRV) (in press)

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See detailLe Livre et l’Imprimerie : étude sur la production des bibles latines au XVe siècle
Adam, Renaud ULg

in Hermand, Xavier; Ruzzier, Chiara (Eds.) Comment le Livre s’est fait livre. La fabrication des manuscrits bibliques (IVe - XVe siècle) : Bilan, résultats, perspectives de recherche / How the Bible became a Book. The Making of Biblical Manuscripts (4th - 15th centuries) : Appraisals and Perspectives (in press)

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See detailPaul Hymans, la Belgique et les affaires internationales (1914-1927). Un homme et un État dans la « hiérarchie »
Genin, Vincent ULg

in L’arbitre de l’Europe. Fixer, penser, contester les hiérarchies politiques en Europe (in press)

Detailed reference viewed: 60 (26 ULg)