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See detailT2-weighted MRI signal predicts hormone and tumor responses to somatostatin analogs in acromegaly.
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Daly, Adrian ULg et al

in Endocrine-Related Cancer (2016), 23(11), 871881

GH-secreting pituitary adenomas can be hypo-, iso- or hyperintense on T2-weighted MRI sequences. We conducted the current multicenter study in a large population of patients with acromegaly to analyze the ... [more ▼]

GH-secreting pituitary adenomas can be hypo-, iso- or hyperintense on T2-weighted MRI sequences. We conducted the current multicenter study in a large population of patients with acromegaly to analyze the relationship between T2-weighted signal intensity on diagnostic MRI and hormonal and tumoral responses to somatostatin analogs (SSA) as primary monotherapy. Acromegaly patients receiving primary SSA for at least 3 months were included in the study. Hormonal, clinical and general MRI assessments were performed and assessed centrally. We included 120 patients with acromegaly. At diagnosis, 84, 17 and 19 tumors were T2-hypo-, iso- and hyperintense, respectively. SSA treatment duration, cumulative and mean monthly doses were similar in the three groups. Patients with T2-hypointense adenoma had median SSA-induced decreases in GH and IGF-1 of 88% and 59% respectively, which were significantly greater than the decreases observed in the T2-iso- and hyperintense groups (p<0.001). Tumor shrinkage on SSA was also significantly greater in the T2-hypointense group (38%) compared with the T2-iso- and hyperintense groups (8% and 3%, respectively; p<0.0001). The response to SSA correlated with the calculated T2-intensity: the lower the T2-weighted intensity, the greater the decrease of random GH (p<0.0001, r=0.22), IGF-1 (p<0.0001, r=0.14) and adenoma volume (p<0.0001, r=0.33). The T2-weighted signal intensity of GH-secreting adenomas at diagnosis correlates with the hormone reduction and tumor shrinkage in response to primary SSA treatment in acromegaly. This study supports its use as a generally available predictive tool at diagnosis that could help to guide subsequent treatment choices in acromegaly. [less ▲]

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See detailCharacterization of Forests with LiDAR Technology
Michez, Adrien ULg; Bauwens, Sébastien ULg; Bonnet, Stéphanie ULg et al

in Baghdadi, Nicolas; Zribi, Mehrez (Eds.) Land Surface Remote Sensing in Agriculture and Forest (2016)

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See detailStudy on contribution of lipids towards the mechanical properties of milk fat globule membrane monolayer
Malik, Priyanka ULg; Danthine, Sabine ULg; Blecker, Christophe ULg

Conference (2016, September 20)

Milk fat globule membrane (MFGM) stabilizes fat globule in milk in form of emulsion. The primary monolayer of MFGM is rich in proteins and secondary bilayer is rich in polar lipids. MFGM finds application ... [more ▼]

Milk fat globule membrane (MFGM) stabilizes fat globule in milk in form of emulsion. The primary monolayer of MFGM is rich in proteins and secondary bilayer is rich in polar lipids. MFGM finds application as an additive in dairy and food industry (e.g. emulsions, infant formulas & reduced-fat products) for its emulsifying and stabilizing properties. MFGM received much attention in recent years due to both its health- beneficial & technological functionalities. This work has been carried out with the objective to understand contribution of various components towards the surface properties of complete MFGM. MFGM was isolated from fresh raw cream. During isolation of MFGM apart from polar lipids and MFGM proteins, neutral lipids are also isolated which have their origin in fat globules but are often considered as a constituent of MFGM. The MFGM was further fractioned into lipid fraction, defatted fraction and polar lipids. The mechanical properties of monolayer were studied for the above fractions using Langmuir film balance. Study of surface properties can also be linked to their techno-functional properties by calculating film elasticity of the compression isotherm which can be linked to emulsifying and stabilizing properties. The analysis of compression isotherms revealed that film elasticity is highly influenced by polar lipids. The behaviour of the MFGM appeared to be influenced by neutral lipid and defatted fraction during beginning of compression and by polar lipids at the end of compression. [less ▲]

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See detailValorization of Seeds from Some Field Border Flowering Seeds
Paul, Aman ULg; Danthine, Sabine ULg; Mutwale Kapepula, Paulin ULg et al

Poster (2016, September 20)

Flowering strips are now being increasingly cultivated along the fields to improve biodiversity. However after serving for the desired function, these plants have no utilization besides animal feed. It ... [more ▼]

Flowering strips are now being increasingly cultivated along the fields to improve biodiversity. However after serving for the desired function, these plants have no utilization besides animal feed. It could be really interesting to valorize some commonly grown plant in these strips to render food or health promoting compounds. With this objective in mind the seeds of Achillea millefolium, Anthriscus sylvestris and Prunella vulgaris were investigated for lipids, proteins and phenolic content. Further the lipids were analyzed for fatty acid profile using gas chromatography and the phenolic compounds in the methanolic extract of defatted seeds were identified using HPLC-DAD. The antiradical activity of the methanolic extracts obtained from defatted seeds was investigated using DPPH and ABTS assays. The anti-inflammatory potential of these seed extracts was evaluated on the reactive oxygen species (ROS) production by stimulated neutrophils and on the specific activity of myeloperoxidase (MPO), a pro-oxidant enzyme marker of inflammation. Seeds from all three plants were analyzed with interesting levels of lipids, proteins and phenolic content. Linoleic acid, oleic acid and alpha-linolenic acid were the major fatty acids analyzed in A. millefolium, A. sylvestris and P. vulgaris respectively. On the other hand different phenolic acid formed the major phenolic constituents. Seed extracts displayed high ABTS and DPPH radical-scavenging activities in a dose dependent manner. Also a strong dose dependent anti-inflammatory activity of all three extracts was observed against ROS production by neutrophils and MPO activity. Results indicate that these seed show a great potential to render lipids which could be utilized as human food, further the defatted seeds could be directly included in human diet due to interesting levels of proteins and anti-inflammation ability. [less ▲]

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See detailDevelopment and validation of analytical methods for quantifying isoflavones and equol in biological matrices
Daems, Frédéric ULg

Doctoral thesis (2016)

Isoflavones are natural plant substances that attract widespread interest because of their association with a large variety of beneficial effects on human health. When they are ingested by animals or ... [more ▼]

Isoflavones are natural plant substances that attract widespread interest because of their association with a large variety of beneficial effects on human health. When they are ingested by animals or humans, most of these compounds are metabolized by bacteria present in the digestive system. Among the isoflavone microbial metabolites, equol is probably the most widely studied because it seems to have numerous health benefits. In the human population, however, not everyone is able to produce equol. Equol enrichment of some food, such as cow's milk, could be an alternative strategy for making equol’s health benefits available to everyone. The main objective of the present thesis was to develop analytical tools for quantifying these compounds in several biological matrices, thus contributing to the feasibility study being conducted on producing milk naturally enriched with equol. For this purpose, four analytical procedures, using ultra performance liquid chromatography coupled with tandem mass spectrometry (UPLC®-MS/MS), were developed and fully validated. The analytical tools were then applied successfully in two original exploratory studies that sought to quantify equol concentrations in commercial cow's milk in Belgium and study the evolution of isoflavone concentration in red clover (Trifolium pratense L.) silage in laboratory-scale silos. This thesis describes new and reliable analytical tools that will help to improve current knowledge about the feasibility of producing cow's milk naturally enriched with equol and to study isoflavone metabolization in dairy cow. [less ▲]

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See detailThe link between self-perceptions of aging, cancer view and physical and mental health of older people with cancer: A cross-sectional study
Schroyen, Sarah ULg; Marquet, Manon ULg; Jerusalem, Guy ULg et al

in Journal of Geriatric Oncology (2016)

Objectives Older people may suffer from stigmas linked to cancer and aging. Although some studies suggested that a negative view of cancer may increase the level of depression, such an association has ... [more ▼]

Objectives Older people may suffer from stigmas linked to cancer and aging. Although some studies suggested that a negative view of cancer may increase the level of depression, such an association has never been studied in the elderly population. Similarly, even though it is established that a negative self-perception of aging has deleterious consequences on mental and physical health in normal aging, the influence in pathological contexts, such as oncology, has not been studied. The main aim of this study is thus to analyze the effect of these two stigmas on the health of elderly oncology patients. Materials and Methods 101 patients suffering from a cancer (breast, gynecological, lung or hematological) were seen as soon as possible after their diagnosis. Their self-perception of age, cancer view and health (physical and mental) was assessed. Results Multiple regressions showed that patients with a more negative self-perception of aging and/or more negative cancer view reported poorer global health. We also observed that negative self-perception of aging was associated with worse physical and mental health, whereas negative cancer views were only linked to worse mental health. No interaction was observed between these two stigmas, suggesting that their action is independent. Conclusion Older patients with cancer face double stigmatization, due to negative self-perception of aging and cancer, and these stigmas have impacts on global and mental health. Self-perception of aging is also linked to physical health. Longitudinal studies will be necessary to analyze the direction of the association between this double stigmatization and health. [less ▲]

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See detailImpact du nombre d’alternatives lors d’une tâche de reconnaissance à choix-forcé sur les processus de reconnaissance dans le vieillissement normal
Simon, Jessica ULg; Gilsoul, Jessica ULg; Bastin, Christine ULg

Poster (2016, September 19)

Les tâches de reconnaissance à choix forcé sont classiquement utilisées pour évaluer la mémoire de reconnaissance. Cependant, aucune étude n’a spécifiquement investigué l’impact du nombre d’alternatives ... [more ▼]

Les tâches de reconnaissance à choix forcé sont classiquement utilisées pour évaluer la mémoire de reconnaissance. Cependant, aucune étude n’a spécifiquement investigué l’impact du nombre d’alternatives sur les performances mnésiques des participants âgés. Nous voulons déterminer, d’une part, si le nombre d’alternatives proposées - deux ou trois – et d’autre part, si le degré de similarité entre la cible et ses leurres ont un impact sur les stratégies de récupération mises en place au cours de la tâche. Pour ce faire, nous avons recruté 20 participants jeunes et 20 participants âgés. Lors de la tâche de reconnaissance, nous leur avons demandé de choisir, parmi deux ou trois photographies de visages, celui qui a été présenté précédemment. Certains couples cibles-leurres étaient plus similaires que d’autres (partage de 60% de caractéristiques communes, contre 40%). Pour chaque item sélectionné, les participants devaient expliquer ce qui a guidé leur choix. Les premières analyses (ANOVA à mesures répétées 2 (groupes) x 2 (alternatives) x 2 (similarité) sur les deux dernières mesures, p<0,05) montrent que les performances entre les groupes sont équivalentes pour la tâche de reconnaissance à deux alternatives. A l’inverse, nous avons observé que les participants jeunes avaient significativement de meilleures performances que les âgés dans la tâche de reconnaissance à trois alternatives. Les profils mnésiques des participants seront étudiés à la lumière des modèles à deux processus de la reconnaissance. Nous faisons l’hypothèse d’un recours plus fréquent à la recollection chez les jeunes dans la tâche de reconnaissance à trois alternatives (vs deux alternatives), alors que le choix de l’item se ferait chez les âgés, en comparant directement les degrés de familiarité associés à chaque item et en sélectionnant le plus familier (Norman & O’Reilly, 2003). [less ▲]

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See detailDynamic interactions of a supercritical aerofoil in the presence of transonic shock buffet
Giannelis, N. F.; Vio, G. A.; Dimitriadis, Grigorios ULg

in Proceedings of the International Conference on Noise and Vibration Engineering, ISMA 2016 (2016, September 19)

Within a narrow transonic flight region, shock-wave/boundary-layer interactions yield large amplitude, self sustained shock oscillations that are detrimental to both platform handling quality and ... [more ▼]

Within a narrow transonic flight region, shock-wave/boundary-layer interactions yield large amplitude, self sustained shock oscillations that are detrimental to both platform handling quality and structural integrity. In this study, the aeroelastic interactions between this transonic buffet instability and a spring-suspended supercritical aerofoil are investigated by means of Reynolds-Averaged Navier-Stokes simulations. Single degree-of-freedom pitching simulations are performed for a range of structural to aerodynamic frequency ratios, sectional mass ratios and levels of structural damping. The results show that for a range of pitch eigenfrequencies above the fundamental buffet frequency, sychronisation of the aerodynamic and structural modes occurs. This so called lock-in phenomenon acts as a mechanism for large amplitude Limit Cycle Oscillation in aircraft structures within the transonic flow regime. The sectional mass and the addition of structural damping are both found to have a pronounced effect on the nature of the limit cycles [less ▲]

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See detailNonlinear identification and control of Organic Rankine Cycle systems using sparse polynomial models
Hernandez, Andres; Ruiz, Fredy; Ionescu, Clara et al

in Proceedings of the 2016 IEEE Conference on Control Applications (CCA) Part of 2016 IEEE Multi-Conference on Systems and Contro (2016, September 19)

Development of a first principles model of a system is not only a time- and cost- consuming task, but often leads to model structures which are not directly usable to design a controller using current ... [more ▼]

Development of a first principles model of a system is not only a time- and cost- consuming task, but often leads to model structures which are not directly usable to design a controller using current available methodologies. In this paper we use a sparse identification procedure to obtain a nonlinear polynomial model. Since this is a NP-hard problem, a relaxed algorithm is employed to accelerate its convergence speed. The obtained model is further used inside the nonlinear Extended Prediction Self-Adaptive control (NEPSAC) approach to Non- linear Model Predictive Control (NMPC), which replaces the complex nonlinear optimization problem by a simpler iterative quadratic programming procedure. An organic Rankine cycle system, characterized for presenting nonlinear time-varying dynamics, is used as benchmark to illustrate the effectiveness of the proposed combined strategies. [less ▲]

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See detailRaffinement de l'estimation asymptotique de l'exposant de Hölder
Kleyntssens, Thomas ULg; Nicolay, Samuel ULg

Conference (2016, September 19)

Dans cet exposé, nous proposons une nouvelle approche basée sur les ondelettes (via les espaces Snu) permettant d'étudier plus finement la régularité Höldérienne d'une fonction

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See detailStretching the ecosystem service concept for application in real world situations
Boeraeve, Fanny ULg; Jacobs, Sander; Dendoncker, Nicolas et al

Conference (2016, September 19)

Detailed reference viewed: 13 (0 ULg)
See detailLes détournements artistiques du jeu vidéo / When art hijacks video games
Barnabé, Fanny ULg; Meyers, Raquel; Vilela, Tatiana

Conference given outside the academic context (2016)

Video games are an inexhaustible source for the production of tools and content that anyone can take possession of as and when they wish. For players, this means indulging in the creation of fanfiction ... [more ▼]

Video games are an inexhaustible source for the production of tools and content that anyone can take possession of as and when they wish. For players, this means indulging in the creation of fanfiction, machinima, modding or speedrunning. But video games are also modified by artists, whether for producing glitch art or designing (video)game experiments, etc. To discuss the areas in which these artistic alterations of video games are made, a round table will bring together: Fanny Barnabé, a PhD student in Liège whose thesis is on various ways of modifying video games; Raquel Meyers, who develops artistic experiments in text mode, starting with the Commodore 64; and Tatiana Vilela, a digital artist who specialises in designing gaming experiments. [less ▲]

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See detailLes déclarations non vérifiées de témoins au regard du procès équitable
Michiels, Olivier ULg; Falque, Géraldine ULg

in Journal des Tribunaux (2016), (6656), 485-490

Dans l’arrêt Schatschaschwili contre Allemagne, la Cour européenne des droits de l’homme s’est particulièrement attachée à préciser les principes qui s’appliquent aux déclarations d’un témoin absent au ... [more ▼]

Dans l’arrêt Schatschaschwili contre Allemagne, la Cour européenne des droits de l’homme s’est particulièrement attachée à préciser les principes qui s’appliquent aux déclarations d’un témoin absent au procès, susceptibles de fonder la culpabilité d’un accusé. Les éclaircissements que l’arrêt de la Grande Chambre ambitionne d’apporter à ce sujet retiendront notre attention dès lors que l’équité du procès pourrait être compromise par la déposition d’un témoin que la défense n’a pas pu, directement ou indirectement, faire interroger. Après avoir rappelé le contexte factuel et procédural dans lequel s’inscrit la cause, nous tenterons de dégager les lignes de force de l’arrêt commenté. Enfin, nous nous efforcerons de mettre ces enseignements en perspective avec la jurisprudence de la cour de Cassation relative à l’article 6, § 3, d) de la Convention qui reconnaît notamment le droit à tout accusé d’interroger ou faire interroger un témoin à charge, pour terminer par une brève conclusion. [less ▲]

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See detailLes technologies génétiques, entre éthique et politique
Caeymaex, Florence ULg

Conference (2016, September 17)

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