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See detailFacteurs pronostiques de décès chez des sujets résidant en maison de repos suivis d'une manière prospective pendant une période de 2 ans
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Slomian, Justine ULg et al

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2014), 12(1), 73-74

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See detailEvolution sur deux ans des capacités fonctionnelles et motrices de sujets âgés résidant en maison de repos
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Slomian, Justine ULg et al

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2014), 12(1), 57-58

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See detailA Partial Least Squares Analysis of the self reference effect in Alzheimer's disease: A reply to Irish
Genon, Sarah ULg; Bastin, Christine ULg; Angel, Lucie et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 54

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See detailThinking out of the box - New approaches to controlling GVHD
Baron, Frédéric ULg; Humblet-Baron, Stéphanie; Ehx, Grégory ULg et al

in Current Hematologic Malignancy Reports (2014), 9

Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD ... [more ▼]

Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD prophylaxis regimens continue to bebased on the combination of a calcineurin inhibitor with an antimetabolite, while first line treatmentsstill relies on high-dose corticosteroids. Further, no second line treatment has emerged thus far in acute or chronic GVHD patients who failed on corticosteroids. After briefly reviewing current standards of GVHD prevention and treatment, this article will discuss recent approaches that might change GVHD prophylaxis / treatment in the next decades, with a special focus on recently developed immunoregulatory strategies based on infusion of mesenchymal stromal or regulatory T-cells, or on injection of lowdose interleukin-2. [less ▲]

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See detailCommon Security and Defence Policy Module - External Evaluation Report
Paile, Sylvain ULg

Book published by Ministry of Defence and Sports of the Federal Republic of Austria (2014)

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See detailBelgian mud mounds, facies and structure and stromatoporoid fauna
Da Silva, Anne-Christine ULg; Kershaw, S.; Boulvain, Frédéric ULg et al

in Wesenberg Lauridsen, b.; Bjerager, M. (Eds.) Cold water carbonates at high paleolatitudes from the Palaeozoic to the Reent – combining outcrops studies with core studies and geophysical imaging. Programme and abstract book (2014)

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See detailThe mitochondrial respiratory chain of the secondary green alga Euglena gracilis shares many additional subunits with parasitic Trypanosomatidae.
Perez, Emilie ULg; Lapaille, Marie; Degand, Herve et al

in Mitochondrion (2014)

The mitochondrion is an essential organelle for the production of cellular ATP in most eukaryotic cells. It is extensively studied, including in parasitic organisms such as trypanosomes, as a potential ... [more ▼]

The mitochondrion is an essential organelle for the production of cellular ATP in most eukaryotic cells. It is extensively studied, including in parasitic organisms such as trypanosomes, as a potential therapeutic target. Recently, numerous additional subunits of the respiratory-chain complexes have been described in Trypanosoma brucei and Trypanosoma cruzi. Since these subunits had apparently no counterparts in other organisms, they were interpreted as potentially associated with the parasitic trypanosome lifestyle. Here we used two complementary approaches to characterise the subunit composition of respiratory complexes in Euglena gracilis, a non-parasitic secondary green alga related to trypanosomes. First, we developed a phylogenetic pipeline aimed at mining sequence databases for identifying homologs to known respiratory-complex subunits with high confidence. Second, we used MS/MS proteomics after two-dimensional separation of the respiratory complexes by Blue Native- and SDS-PAGE to both confirm in silico predictions and to identify further additional subunits. Altogether, we identified 41 subunits that are restricted to E. gracilis, T. brucei and T. cruzi, along with 48 classical subunits described in other eukaryotes (i.e. plants, mammals and fungi). This moreover demonstrates that at least half of the subunits recently reported in T. brucei and T. cruzi are actually not specific to Trypanosomatidae, but extend at least to other Euglenozoa, and that their origin and function are thus not specifically associated with the parasitic lifestyle. Furthermore, preliminary biochemical analyses suggest that some of these additional subunits underlie the peculiarities of the respiratory chain observed in Euglenozoa. [less ▲]

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See detailAssociation of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood.
Savenije, Olga E.; Mahachie John, Jestinah ULg; Granell, Raquel et al

in The Journal of allergy and clinical immunology (2014)

BACKGROUND: Genome-wide association studies identified IL33 and IL-1 receptor-like 1 (IL1RL1)/IL18R1 as asthma susceptibility loci. IL33 and IL1RL1 constitute a single ligand-receptor pathway. OBJECTIVE ... [more ▼]

BACKGROUND: Genome-wide association studies identified IL33 and IL-1 receptor-like 1 (IL1RL1)/IL18R1 as asthma susceptibility loci. IL33 and IL1RL1 constitute a single ligand-receptor pathway. OBJECTIVE: In 2 birth cohorts, the Prevalence and Incidence of Asthma and Mite Allergy (PIAMA) study and Avon Longitudinal Study of Parents and Children (ALSPAC), we analyzed associations of longitudinal wheezing phenotypes and asthma with single nucleotide polymorphisms (SNPs) of 8 genes encoding IL-33, IL1RL1, its coreceptor IL1RAcP, its adaptors myeloid differentiation primary response gene 88 (MyD88) and Toll-IL-11 receptor domain containing adaptor protein (TIRAP), and the downstream IL-1 receptor-associated kinase 1, IL-1 receptor-associated kinase 4, and TNF receptor-associated factor 6 (TRAF6). Furthermore, we investigated whether SNPs in this pathway show replicable evidence of gene-gene interaction. METHODS: Ninety-four SNPs were investigated in 2007 children in the PIAMA study and 7247 children in ALSPAC. Associations with wheezing phenotypes and asthma at 8 years of age were analyzed in each cohort and subsequently meta-analyzed. Gene-gene interactions were assessed through model-based multifactor dimensionality reduction in the PIAMA study, and gene-gene interactions of 10 SNP pairs were further evaluated. RESULTS: Intermediate-onset wheeze was associated with SNPs in several genes in the IL33-IL1RL1 pathway after applying multiple testing correction in the meta-analysis: 2 IL33 SNPs (rs4742170 and rs7037276), 1 IL-1 receptor accessory protein (IL1RAP) SNP (rs10513854), and 1 TRAF6 SNP (rs5030411). Late-onset wheeze was associated with 2 IL1RL1 SNPs (rs10208293 and rs13424006), and persistent wheeze was associated with 1 IL33 SNP (rs1342326) and 1 IL1RAP SNP (rs9290936). IL33 and IL1RL1 SNPs were nominally associated with asthma. Three SNP pairs showed interaction for asthma in the PIAMA study but not in ALSPAC. CONCLUSIONS: IL33-IL1RL1 pathway polymorphisms are associated with asthma and specific wheezing phenotypes; that is, most SNPs are associated with intermediate-onset wheeze, a phenotype closely associated with sensitization. We speculate that IL33-IL1RL1 pathway polymorphisms affect development of wheeze and subsequent asthma through sensitization in early childhood. [less ▲]

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See detailReaching the 1% accuracy level on stellar mass and radius determinations from asteroseismology
Van Grootel, Valérie ULg; Charpinet, Stephane; Fontaine, Gilles et al

in Proceedings of the International Astronomical Union (2014), 301

Asteroseismic modeling of subdwarf B (sdB) stars provides measurements of their fundamental parameters with a very good precision; in particular, the masses and radii deter- mined from asteroseismology ... [more ▼]

Asteroseismic modeling of subdwarf B (sdB) stars provides measurements of their fundamental parameters with a very good precision; in particular, the masses and radii deter- mined from asteroseismology are found to typically reach a precision of 1% containing various uncertainties associated with their inner structure and the underlying microphysics (composition and transition zones profiles, nuclear reaction rates, etc.). Therefore, the question of the accuracy of the stellar parameters derived by asteroseismology is legitimate. We present here the seismic modeling of the pulsating sdB star in the eclipsing binary PG 1336-018, for which the mass and the radius are independently and precisely known from the modeling of the reflection/irradiation effect and the eclipses observed in the light curve. This allows us to quantitatively evaluate the reliability of the seismic method and test the impact of uncertainties in our stellar models on the derived parameters. We conclude that the sdB star parameters inferred from asteroseismology are precise, accurate, and robust against model uncertainties. [less ▲]

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See detailSartre, les passions de la liberté. Phénoménologie, politique, savoirs critiques
Cormann, Grégory ULg

Book published by Peter Lang (2014)

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See detailCusp observation at Saturn’s high-latitude magnetosphere by the Cassini spacecraft
Jasinski; Arridge; Lamy et al

in Geophysical Research Letters (2014)

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See detailPrevalence of sarcopenia according to different diagnostic tools
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Slomian, Justine ULg et al

in Journal of Frailty & Aging (2014), 3(1), 43

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See detailEvolution over two years of functional and motor abilities among nursing home residents
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Slomian, Justine ULg et al

in Journal of Frailty & Aging (2014), 3(1), 45

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See detailaktives Affix
Münzberg, Franziska ULg

in Schierholz, Stefan J.; Dürscheid, Christa (Eds.) Grammatik - Formenlehre (2014)

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See detailCombining flux estimation techniques to improve characterization of groundwater–surface-water interaction in the Zenne River, Belgium
Dujardin, Juliette; Anibas, Christian; Bronders, Jan et al

in Hydrogeology Journal (2014)

The management of urban rivers which drain contaminated groundwater is suffering from high uncertainties regarding reliable quantification of groundwater fluxes. Independent techniques are combined for ... [more ▼]

The management of urban rivers which drain contaminated groundwater is suffering from high uncertainties regarding reliable quantification of groundwater fluxes. Independent techniques are combined for estimating these fluxes towards the Zenne River, Belgium. Measured hydraulic gradients, temperature gradients in conjunction with a 1D-heat and fluid transport model, direct flux measurement with the finite volume point dilution method (FVPDM), and a numerical groundwater flow model are applied, to estimate vertical and horizontal groundwaterfluxes and groundwater–surface-water interaction. Hydraulic gradient analysis, the temperature-based method, and the groundwaterflow model yielded average verticalfluxes of–61,–45 and–40 mm/d, respectively. The negative sign indicates upwardflow to the river. Changes in exchangefluxes are sensitive to precipitation but the river remained gaining during the examined period. The FVPDM, compared to the groundwaterflow model, results in two very high estimates of the horizontal Darcyfluxes (2,600 and 500 mm/d), depending on the depth of application. The obtained results allow an evaluation of the temporal and spatial variability of estimated fluxes, thereby helping to curtail possible consequences of pollution of the Zenne River as final receptor, and contribute to the setup of a suitable remediation plan for the contaminated study site. [less ▲]

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See detailNanoparticle Growth in Supported Nickel Catalysts during Methanation Reaction-Larger is Better
Munnik, Peter; Velthoen, Marjolein; de Jongh, Petra et al

in Angewandte Chemie International Edition (2014)

A major cause of supported metal catalyst deactivation is particle growth by Ostwald ripening. Nickel catalysts, used in the methanation reaction, may suffer greatly from this through the formation of [Ni ... [more ▼]

A major cause of supported metal catalyst deactivation is particle growth by Ostwald ripening. Nickel catalysts, used in the methanation reaction, may suffer greatly from this through the formation of [Ni(CO)4]. By analyzing catalysts with various particle sizes and spatial distributions, the interparticle distance was found to have little effect on the stability, because formation and decomposition of nickel carbonyl rather than diffusion was rate limiting. Small particles (3–4 nm) were found to grow very large (20–200 nm), involving local destruction of the support, which was detrimental to the catalyst stability. However, medium sized particles (8 nm) remained confined by the pores of the support displaying enhanced stability, and an activity 3 times higher than initially small particles after 150 h. Physical modeling suggests that the higher [Ni(CO)4] supersaturation in catalysts with smaller particles enabled them to overcome the mechanical resistance of the support. Understanding the interplay of particle size and support properties related to the stability of nanoparticles offers the prospect of novel strategies to develop more stable nanostructured materials, also for applications beyond catalysis. [less ▲]

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