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See detailEvaluation de l’efficacité de la simulation haute fidélité dans la prise en charge des troubles du rythme cardiaque chez l’enfant: étude pilote
SCHUMACHER, Katharina ULg; Seghaye, Marie-Christine ULg; Baugnon, Thomas et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015, March), 17(1),

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See detailStrain localization modelling around an underground gallery in Mol with an analysis of the contact pressure on the lining
Salehnia, Fatemeh ULg; Dizier, Arnaud; Li, Xiang Ling et al

Poster (2015, March)

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See detailReflections about the optimisation of the treatment of tendinopathies with PRP
Kaux, Jean-François ULg; Bouvard, Marc; LECUT, Christelle ULg et al

in Muscles, Ligaments and Tendons Journal (2015), 5(1 (eCollection 2015 Jan-Mar)), 1-4

Background: platelet-rich plasma (PRP) infiltration represents a recent therapy for chronic tendinopathies. However, in the literature, this treatment remains controversial. Purpose: we suggest some ideas ... [more ▼]

Background: platelet-rich plasma (PRP) infiltration represents a recent therapy for chronic tendinopathies. However, in the literature, this treatment remains controversial. Purpose: we suggest some ideas for improving this treatment. Methods: these suggestions were based on a review of published studies and our clinical experience. Conclusion: optimizing the technique for PRP collection is paramount. Different risk factors must be corrected before infiltration and chronic tendinopathies must be carefully selected. Finally, post-infiltration rehabilitation remains absolutely critical. Standardization of the use of PRP remains necessary in order to optimize the results. [less ▲]

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See detailRéflexions relatives au traitement des tendinopathies par infiltration de PRP
KAUX, Jean-François ULg; Bouvard, Marc; Sanchez, Mikel et al

in Journal de Traumatologie du Sport (2015), 32(1), 38-40

Introduction Platelet rich plasma injection (PRP) represents a recent therapy for chronic tendinopathies. However, this treatment remains controversial in clinical studies. Summary of the facts and ... [more ▼]

Introduction Platelet rich plasma injection (PRP) represents a recent therapy for chronic tendinopathies. However, this treatment remains controversial in clinical studies. Summary of the facts and results Based on literature and our experience, we offer few tracks in order to improve this treatment. The optimization of the technique of obtaining the PRP is paramount. Different risk factors must be corrected and the good indications carefully selected. Finally, a post-infiltration rehabilitation remains absolutely necessary. Conclusion Standardisation of the use of the PRP remains necessary in order to optimize the results. [less ▲]

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See detailCharacterization of building materials from the aqueduct of Antioch-on-the-Orontes (Turkey)
Benjelloun, Yacine; de Sigoyer, Julia; Carlut, Julia et al

in Comptes Rendus Geoscience (2015)

The Roman aqueduct of Antioch-on-the-Orontes (Turkey), a city located near the junction between the active Dead Sea fault and the East Anatolian fault, has been damaged several times due to historical ... [more ▼]

The Roman aqueduct of Antioch-on-the-Orontes (Turkey), a city located near the junction between the active Dead Sea fault and the East Anatolian fault, has been damaged several times due to historical earthquakes, as mentioned in ancient texts. The traces of repairs are studied in order to identify their potential seismic origin. The deformations of the structure were characterised thanks to a LIDAR scan. Several bricks were sampled on different parts of the city’s aqueducts, on the original structure and on repaired parts. The bricks were characterized through a petrological approach. 14C and archaeomagnetism were tested on the bricks in order to constrain the age of their production. The synthesis of all the data showed a local origin for the bricks, and led to the identification of several manufacturing techniques and several types of production, thus, confirming the potentiality of this approach to date and characterise post-seismic repairs. [less ▲]

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See detailNecitumumab plus pemetrexed and cisplatin as first-line therapy in patients with stage IV non-squamous non-small-cell lung cancer (INSPIRE): an open-label, randomised, controlled phase 3 study.
Paz-Ares, Luis; Mezger, Jorg; Ciuleanu, Tudor E. et al

in The Lancet. Oncology (2015), 16(3), 328-37

BACKGROUND: Necitumumab is a second-generation recombinant human immunoglobulin G1 EGFR monoclonal antibody that competitively inhibits ligand binding. We aimed to compare necitumumab plus pemetrexed and ... [more ▼]

BACKGROUND: Necitumumab is a second-generation recombinant human immunoglobulin G1 EGFR monoclonal antibody that competitively inhibits ligand binding. We aimed to compare necitumumab plus pemetrexed and cisplatin with pemetrexed and cisplatin alone in patients with previously untreated, stage IV, non-squamous non-small-cell lung cancer (NSCLC). METHODS: We did this randomised, open-label, controlled phase 3 study at 103 sites in 20 countries. Patients aged 18 years or older, with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 and adequate organ function, were randomly assigned 1:1 to treatment with a block randomisation scheme (block size of four) via a telephone-based interactive voice-response system or interactive web-response system. Patients received either cisplatin 75 mg/m(2) and pemetrexed 500 mg/m(2) on day 1 of a 3-week cycle for a maximum of six cycles alone, or with necitumumab 800 mg on days 1 and 8. Necitumumab was continued after the end of chemotherapy until disease progression or unacceptable toxic effects. Randomisation was stratified by smoking history, ECOG performance status, disease histology, and geographical region. Patients and study investigators were not masked to group assignment. The primary endpoint was overall survival. Efficacy analyses were by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00982111. FINDINGS: Between Nov 11, 2009, and Feb 2, 2011, we randomly assigned 633 patients to receive either necitumumab plus pemetrexed and cisplatin (n=315) or pemetrexed and cisplatin alone (n=318). Enrolment was stopped on Feb 2, 2011, after a recommendation from the independent data monitoring committee. There was no significant difference in overall survival between treatment groups, with a median overall survival of 11.3 months (95% CI 9.5-13.4) in the necitumumab plus pemetrexed and cisplatin group versus 11.5 months (10.1-13.1) in the pemetrexed and cisplatin group (hazard ratio 1.01 [95% CI 0.84-1.21]; p=0.96). The incidence of grade 3 or worse adverse events, including deaths, was higher in the necitumumab plus pemetrexed and cisplatin group than in the pemetrexed and cisplatin group; in particular, deaths regarded as related to study drug were reported in 15 (5%) of 304 patients in the necitumumab group versus nine (3%) of 312 patients in the pemetrexed and cisplatin group. Serious adverse events were likewise more frequent in the necitumumab plus pemetrexed and cisplatin group than in the pemetrexed and cisplatin group (155 [51%] of 304 vs 127 [41%] of 312 patients). Patients in the necitumumab plus pemetrexed and cisplatin group had more grade 3-4 rash (45 [15%] of 304 vs one [<1%] of 312 patients in the pemetrexed and cisplatin alone group), hypomagnesaemia (23 [8%] vs seven [2%] patients), and grade 3 or higher venous thromboembolic events (23 [8%] vs 11 [4%] patients) than did those in the pemetrexed and cisplatin alone group. INTERPRETATION: Our findings show no evidence to suggest that the addition of necitumumab to pemetrexed and cisplatin increases survival of previously untreated patients with stage IV non-squamous NSCLC. Unless future studies identify potentially useful predictive biomarkers, necitumumab is unlikely to provide benefit in this patient population when combined with pemetrexed and cisplatin. FUNDING: Eli Lilly and Company. [less ▲]

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See detailCROSSROADS le magazine sonore des musiques africaines-américaines
Sacré, Robert ULg

Diverse speeche and writing (2015)

Programme radio hebdomadaire consacré aux musiques africaines-américaines EQUINOXE FM 100.1 ( région Liège) ; streaming : www.equinoxefm.be ; podcasts www.mixcloud.com/robertsacre9

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See detailCharacterization of Venom Peptides using Microfluidic Separation Techniques coupled to Mass Spectrometry (LC-MS and CE-MS)
Degueldre, Michel ULg; Delvaux, Cédric ULg; Far, Johann ULg et al

Poster (2015, March)

More than the half of the principal sub-kingdoms of the animal world contains species that produce venom whose purposes are to immobilize, kill and pre-digest the preys. These venoms represent an ... [more ▼]

More than the half of the principal sub-kingdoms of the animal world contains species that produce venom whose purposes are to immobilize, kill and pre-digest the preys. These venoms represent an exceptionally rich source of various biologically active peptides, both in their structures and their effects, which are more and more useful for human being1. Yet, the total characterization of such complex samples require advanced analytical techniques mainly due to the complexity of the sample (hundreds of compounds), the limited quantities usually available and the presence of numerous PTMs, especially disulfide bridges and specific folding. Here we present a method that combines LC and CE separation techniques coupled to mass spectrometry (MS) to characterize the peptide composition of the snake venom Naja atra. The characterization will not only focus on the toxin sequencing (LC-MS and LC-MS/MS), but will also aim at analyzing the folding of the toxins (CE-MS). To this end, native and reduced/alkylated toxins will be analyzed by both techniques. Final result targets the determination of the global hydrophobic pattern and native tridimensional folding of these strongly reticulated peptides. (1) Richard J. Lewis & Maria L. Garcia, Therapeutic potential of venom peptides. Nature Reviews Drug Discovery 2003, 2, 790-802. [less ▲]

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See detailÉcrire le geste par l'image. Graphies, cinégraphies et vidéographies
Tomasovic, Dick ULg

Article for general public (2015)

i les pratiques de notations des gestes, des postures et des phrases chorégraphiques ont offert un riche éventail de textualités, il apparaît que celui-ci s’est fortement restreint dans la dernière partie ... [more ▼]

i les pratiques de notations des gestes, des postures et des phrases chorégraphiques ont offert un riche éventail de textualités, il apparaît que celui-ci s’est fortement restreint dans la dernière partie de la seconde moitié du 20e siècle. La raison en serait l’apparition de la vidéo, permettant de manière simple, légère et peu onéreuse d’enregistrer de manière audiovisuelle les travaux chorégraphiques. S’il peut souvent s’agir de simples « captures témoin » de l’événement chorégraphique, conceptualisées comme un miroir doté de mémoire, réfléchissant et enregistrant les mouvements qui lui sont soumis, nombre d’artistes ont pourtant considéré cette opportunité technologique comme une nouvelle possibilité d’écriture. [less ▲]

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See detailNIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways.
Rapino, Francesca ULg; Abhari, BA; Jung, M et al

in Cell Death & Disease (2015)

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See detailComment je traite ... une mucoviscidose
BENDAVID, G.; VANDERHELST, E.; LOUIS, Renaud ULg et al

in Revue Médicale de Liège (2015), 70(3), 108-114

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See detailHydro-mechanical simulation in a deep excavation in Boom Clay
Hong, P.Y.; Cui, Y.J.; Pereira, J.M. et al

Poster (2015, March)

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See detailA two-surface viscoplastic model for saturated clays
Hong, P.Y.; Cui, Y.J.; Pereira, J.M. et al

Poster (2015, March)

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See detailVolontairement impliqués en pauvreté. Evaluation de la formation
Absil, Gaëtan ULg; Luffin, André

Report (2015)

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See detailAssessing variability of literature based methane indicator traits in a large dairy cow population
Kandel, Purna Bhadra ULg; Gengler, Nicolas ULg; Soyeurt, Hélène ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19(1), 11-19

Description du sujet. La production laitière est reconnue comme une des sources majeures d’émissions de méthane (CH4). Le recours à un programme de sélection spécifique pourrait être une bonne méthode ... [more ▼]

Description du sujet. La production laitière est reconnue comme une des sources majeures d’émissions de méthane (CH4). Le recours à un programme de sélection spécifique pourrait être une bonne méthode pour optimiser les émissions de méthane par les vaches laitières. Le développement d’un tel programme nécessiterait un nombre important d’enregistrements relatifs aux émissions de méthane. Malheureusement, aucune méthode pratique et bon marché n’existe actuellement pour créer une telle base de données. Cependant, quatre indicateurs CH4 basés sur les quantités en acides gras dans la matière grasse laitière ont été recensés dans la littérature. Objectifs. L’objectif de cette étude est d’utiliser ces indicateurs de la littérature afin d’apprécier la variabilité des émissions de méthane éructées par les vaches laitières. Méthode. Ces indicateurs utilisent les quantités en acides gras obtenues par chromatographie en phase gazeuse. Comme ce type de données n’est pas disponible pour toute la population laitière, un échantillon de 602 analyses chromatographiques a été créé dans cette étude afin de développer une équation de calibrage permettant de prédire les quantités de méthane émises à partir du spectre moyen infrarouge (MIR) du lait qui est disponible pour toutes les vaches étudiées. Ensuite, l’équation de calibrage ainsi obtenue a été appliquée sur 604 028 données spectrales enregistrées entre 2007 et 2011 auprès de 70 872 vaches au cours de leurs trois premières lactations afin de prédire les quantités de méthane émises. Les paramètres génétiques de ces nouveaux indicateurs méthane prédits par MIR ont également été estimés en utilisant un modèle animal de type jour de test avec régressions aléatoires. Résultats. Ces quantités prédites par MIR variaient selon une gamme attendue s’étalant entre 350 ± 40 et 449 ± 65 g par jour. L’émission prédite moyenne de CH4 en g par jour augmentait au début de la lactation, atteignait sa plus haute concentration au pic de lactation et ensuite diminuait jusqu’à la fin de la lactation. Les héritabilités journalières moyennes variaient entre 0,29-0,35 ; 0,26-0,40 et 0,22-0,37 pour les différents indicateurs méthane étudiés au cours des trois premières lactations. Les plus grandes différences entre les valeurs d’élevage estimées pour des taureaux ayant des filles en production émettant le plus et le moins de méthane étaient de 24,18 ; 29,33 et 27,77 kg par lactation pour les trois premières lactations. Des corrélations faiblement négatives ont été observées entre les indicateurs CH4 et la quantité de lait. À l’inverse, des corrélations positives ont été estimées entre ces mêmes indicateurs et les taux en matières grasses et en protéines. Conclusions. Cette étude montre la possibilité de prédire des indicateurs méthane issus de la littérature et utilisant les concentrations en acides gras dans la matière grasse laitière à partir de la spectrométrie MIR. De plus, cette étude suggère également à partir des paramètres génétiques obtenus l’existence d’une variabilité phénotypique et génétique des quantités de méthane éructées par les vaches laitières Holstein. [less ▲]

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See detailA comparison of grey-box and black-box approaches in nonlinear state-space modelling and identification
Noël, Jean-Philippe ULg; Schoukens, Johan; Kerschen, Gaëtan ULg

Conference (2015, March)

In the present contribution, it is shown that, in the case of mechanical systems where nonlinearities are physically localised, the general structure of black-box nonlinear state-space models can be ... [more ▼]

In the present contribution, it is shown that, in the case of mechanical systems where nonlinearities are physically localised, the general structure of black-box nonlinear state-space models can be drastically simplified. A more parsimonious, grey-box state-space representation is derived, which is found to be compatible with Newton's second law of dynamics. For demonstration purposes, black-box and grey-box state-space models of the Silverbox benchmark, i.e. an electrical mimicry of a single-degree-of-freedom mechanical system with cubic nonlinearity, are identified using a maximum likelihood estimator. It is found that the grey-box approach allows to reduce markedly modelling errors with respect to a black-box model with a comparable number of parameters. It is also suggested that the greater accuracy of the grey-box model lends itself to the computation of reliable confidence bounds on the model parameters. [less ▲]

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