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See detailFilter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis.
Grange, Laura; Bureau, Jean-Francois; Nikolayeva, Iryna et al

in BMC genetics (2015), 16(1), 11

BackgroundDeciphering the genetic architecture of complex traits is still a major challenge for human genetics. In most cases, genome-wide association studies have only partially explained the ... [more ▼]

BackgroundDeciphering the genetic architecture of complex traits is still a major challenge for human genetics. In most cases, genome-wide association studies have only partially explained the heritability of traits and diseases. Epistasis, one potentially important cause of this missing heritability, is difficult to explore at the genome-wide level. Here, we develop and assess a tool based on interactive odds ratios (IOR), Fast Odds Ratio-based sCan for Epistasis (FORCE), as a novel approach for exhaustive genome-wide epistasis search. IOR is the ratio between the multiplicative term of the odds ratio (OR) of having each variant over the OR of having both of them. By definition, an IOR that significantly deviates from 1 suggests the occurrence of an interaction (epistasis). As the IOR is fast to calculate, we used the IOR to rank and select pairs of interacting polymorphisms for P value estimation, which is more time consuming.ResultsFORCE displayed power and accuracy similar to existing parametric and non-parametric methods, and is fast enough to complete a filter-free genome-wide epistasis search in a few days on a standard computer. Analysis of psoriasis data uncovered novel epistatic interactions in the HLA region, corroborating the known major and complex role of the HLA region in psoriasis susceptibility.ConclusionsOur systematic study revealed the ability of FORCE to uncover novel interactions, highlighted the importance of exhaustiveness, as well as its specificity for certain types of interactions that were not detected by existing approaches. We therefore believe that FORCE is a valuable new tool for decoding the genetic basis of complex diseases. [less ▲]

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See detailLes vers à soie sauvages à Madagascar : Enjeux écologiques et socio-économiques
Verheggen, François ULg; Haubruge, Eric ULg; Bogaert, Jan ULg

in Entomologie Faunistique = Faunistic Entomology (2015), 68

We here introduce the book « The Malagasy silk moths: ecological and socio-economic challenges » published in 2013 by the Presses agronomiques de Gembloux (Belgium). This book reflects the achievements ... [more ▼]

We here introduce the book « The Malagasy silk moths: ecological and socio-economic challenges » published in 2013 by the Presses agronomiques de Gembloux (Belgium). This book reflects the achievements and scientific activities of the project "Sustainable Management and valorisation of the endemic silkworm Borocera cajani in forest areas in the Antananarivo region" funded by Commission universitaire pour le Développement (CUD - CIUF). [less ▲]

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See detailUsing zero-inlated models to predict the relative distribution and abundance of roe deer over very large spatial scales
Bouyer, Yaëlle ULg; Rigot, Thibaud; Panzacchi, Manuela et al

in Annales Zoologici Fennici (2015), 52

In Norway, recovering populations of large carnivores commonly prey on roe deer (Capreolus capreolus). Understanding predator habitat use and ecology requires fine-scaled information on prey distribution ... [more ▼]

In Norway, recovering populations of large carnivores commonly prey on roe deer (Capreolus capreolus). Understanding predator habitat use and ecology requires fine-scaled information on prey distribution and abundance. However, the massive spatial scales at which large carnivores use the landscape presents many practical and statistical challenges for developing functional prey distribution models. Pellet-count data from >1000 km of transects gathered across southeastern Norway from 2005 to 2011 were used to derive a map of relative prey abundance for roe deer. These data were modeled using zero-inflated hurdle models using both environmental and anthropogenic variables. Snow depth and agricultural fields were the most significant variables in explaining both presence and abundance. Internal k-cross validation of the model showed medium accuracy (Spearman r = 0.35), whereas external evaluation carried out on the basis of independently collected snow-tracking data (Spearman r = 0.37) and hunting statistics (Spearman r = 0.88) showed high accuracy. The map generated can facilitate both the study of broad scale processes linking predators and prey as well as roe deer management in southeastern Norway. [less ▲]

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See detailDoes sector-specific experience matter? The case of European higher education ministers
Lefebvre, Mathieu ULg; Jacqmin, Julien

E-print/Working paper (2015)

This paper looks at the relationship between higher education ministers and the performance of the sector that they govern. Using an original panel dataset with the characteristics of European higher ... [more ▼]

This paper looks at the relationship between higher education ministers and the performance of the sector that they govern. Using an original panel dataset with the characteristics of European higher education ministers, we find that having a past experience in the sector leads to a higher level of performance, as measured by ranking data. Making a parallel with the literature about the impact of education on the educated, we discuss potential explanations behind the impact of this on-the-job learning experience. As we find that this characteristic has no impact on the spendings of the sector, we argue that this academic experience makes them more prone to introduce adequate reforms. Furthermore, we find that this result is driven by ministers with both this sector-specific and an electoral experience, the latter measured by a succesful election at the regional or national level. This tends to show that political credibility should not be overshadowed by the importance of the sector-specific experience of ministers. [less ▲]

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See detailAn engine for global plant diversity: highest evolutionary turnover and emigration in the American tropics
Antonelli, Alexandre; Zizka, Alexander; Silvestro, Daniele et al

in Frontiers in Genetics (2015), 6

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See detailExploring the major depletions of conodont diversity during the Triassic
Martínez-Pérez, Carlos; Cascales - Miñana, Borja ULg; Plasencia, Pablo et al

in Historical Biology (2015), 27(5), 503-507

In this paper, we show that the Triassic fossil record reflects just two great depletions of conodont diversity before the Rhaetian, which occurred in the Smithian (Olenekian, Early Triassic) and in the ... [more ▼]

In this paper, we show that the Triassic fossil record reflects just two great depletions of conodont diversity before the Rhaetian, which occurred in the Smithian (Olenekian, Early Triassic) and in the Julian (Carnian, Late Triassic). By exploring this context, our results highlighted that they respond to different origination-extinction dynamics. Thus, while the Smithian diversity depletion can be interpreted as a consequence of elevated extinction, the Julian diversity depletion was triggered by fluctuations in origination regime. This evidence suggests that, despite the role of extinction on diversity losses, conodonts suffered crucial changes on the origination regimes during the Late Triassic which triggered these events. Notwithstanding, our results indicate that the end-Triassic diversity depletion of conodonts was produced by background extinction levels in a context of lower origination. This suggests that several biological factors, rather than a unique, environmental and/or cyclic cause, could have influenced the evolutionary history of conodonts during the Triassic. © 2014 © 2014 Taylor & Francis. [less ▲]

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See detailDiversity patterns of the vascular plant group Zosterophyllopsida in relation to Devonian palaeogeography
Cascales - Miñana, Borja ULg; Meyer-Berthaud, Brigitte

in Palaeogeography, Palaeoclimatology, Palaeoecology (2015), 423

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See detailWelcome to papers from the Second International Meeting of Agora Paleobotanica
Cascales - Miñana, Borja ULg; Diez, José B.

in Historical Biology (2015), 27(3–4), 291293

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See detailExploitation didactique du Tableau Blanc Interactif (TBI) au cours de langues modernes
Simons, Germain ULg; Pagnoul, Pierre ULg; Van Hoof, Florence ULg

Diverse speeche and writing (2015)

Analyser l'intérêt d'utiliser l'outil informatique TBI pour développer les apprentissages en langues modernes. Outre le fait que le TBI correspond sans doute davantage à la culture des élèves actuels que ... [more ▼]

Analyser l'intérêt d'utiliser l'outil informatique TBI pour développer les apprentissages en langues modernes. Outre le fait que le TBI correspond sans doute davantage à la culture des élèves actuels que le tableau "noir", il permet de rencontrer nombre d'objectifs du cours de langues modernes basé sur l'approche communicative. [less ▲]

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See detailStabilité des Constructions
Denoël, Vincent ULg; Franssen, Jean-Marc ULg

Learning material (2015)

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See detailObesity: A new paradigm for treating obesity and diabetes mellitus.
Scheen, André ULg; Paquot, Nicolas ULg

in Nature reviews. Endocrinology (2015), 11(4), 196-198

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See detailLe catalogue méthodique selon La Serna Santander
Adam, Renaud ULg

in Barbier, Frédéric; Sordet, Yann; Vanautgaerden, Alexandre (Eds.) De l'argile au nuage. Une archéologie des catalogues (IIe millénaire av. J.-C. - XXIe siècle). (2015)

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See detailIsoform 165 of vascular endothelial growth factor in collagen matrix improves ovine cryopreserved ovarian tissue revascularisation after xenotransplantation in mice.
Henry, Laurie ULg; LABIED, Soraya ULg; Fransolet, Maïté ULg et al

in Reproductive biology and endocrinology (2015), 13(1), 15

BACKGROUND: Aggressive anti-cancer treatments can result in ovarian failure. Ovarian cryopreservation has been developed to preserve the fertility of young women, but early graft revascularisation still ... [more ▼]

BACKGROUND: Aggressive anti-cancer treatments can result in ovarian failure. Ovarian cryopreservation has been developed to preserve the fertility of young women, but early graft revascularisation still requires improvement. METHODS: Frozen/thawed sheep ovarian cortical biopsies were embedded in collagen matrix with or without isoform 165 of vascular endothelial growth factor (VEGF165) and transplanted into ovaries of immunodeficient mice. Ovaries were chosen as transplantation sites to more closely resemble clinical conditions in which orthotopic transplantation has previously allowed several spontaneous pregnancies. RESULTS: We found that VEGF165 significantly increased the number of Dextran-FITC positive functional vessels 3 days after grafting. Dextran- fluorescein isothiocyanate (FITC) positive vessels were detectable in 53% and 29% of the mice in the VEGF-treated and control groups, respectively. Among these positive fragments, 50% in the treated group displayed mature smooth-muscle-actin-alpha (alpha-SMA) positive functional vessels compared with 0% in the control group. CD31 positive murine blood vessels were observed in 40% of the VEGF165 transplants compared with 21% of the controls. After 3 weeks, the density of murine vessels was significantly higher in the VEGF165 group. CONCLUSION: The encapsulation of ovarian tissue in collagen matrix in the presence of VEGF165 before grafting has a positive effect on functional blood vessel recruitment. It can be considered as a useful technique to be improved and further developed before human clinical applications in female cancer patients in the context of fertility preservation. [less ▲]

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See detailEffect of improved feeding and housing, Friesian blood level and parity on milk production of Ankole x Friesian cows
Kibwana, Denise Katungu; Makumyaviri, A.M.; Hornick, Jean-Luc ULg

in Pakistan Veterinary Journal (2015), 35(1), 76-80

In North Kivu, D.R. Congo, cattle are raised in extensive systems based on local breeds and crossbreds. This farming method affects the performance of dairy animals and mortgages the level of milk ... [more ▼]

In North Kivu, D.R. Congo, cattle are raised in extensive systems based on local breeds and crossbreds. This farming method affects the performance of dairy animals and mortgages the level of milk consumption in population. An improved farming system, including feed supplementation, Friesian cross-breeding and the sheltering of animals in stalls at night, was studied to evaluate its effect on milk production by Ankole x Friesian crossbreds. The study was performed in Beni, D.R. Congo, on two groups of 15 animals (control group-CoG and improved group-IG), homogeneous according to Friesian blood and parity levels. The improved system, Friesian blood and parity levels increased significantly milk production (P<0.001). Farming system increased milk production by 1.6 l/d (5.2 l/d vs 6.8 l/d respectively in CoG and IG). Milk production ranged from 5.3±0.04 l/d to 6.6±0.02 l/d and from 4.9±0.02 l/d to 7.2±0.02 l/d according, respectively, to Friesian blood level and parity. A significant interaction was observed between farming system and Friesian blood level, and between farming system and parity (P<0.001). The two groups were characterized by a fair adaptation to forage availability associated to climatic factors. The study showed the importance of genetic and environmental factors on the milk production of crossbred dairy cows of the region. [less ▲]

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See detailDes insectes au menu: apports protéiques et nutriments particuliers?
Caparros Megido, Rudy ULg; Alabi, Taofic ULg; Haubruge, Eric ULg et al

in 56èmes Journées Nationales de Diététique et de Nutrition (2015)

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See detailAnalysis of the technical / economic performance of four cropping systems involving Jatropha curcas L. in the Kinshasa Region (Democratic Republic of the Congo)
Minengu, J.D.; Mobambo, P.; Mergeai, Guy ULg

in Tropicultura (2015), 33(2),

In order to assess the sustainability of cultivating Jatropha curcas L. in rural areas in the Kinshasa region, four cropping systems were compared : cultivation of J. curcas as a sole crop with and ... [more ▼]

In order to assess the sustainability of cultivating Jatropha curcas L. in rural areas in the Kinshasa region, four cropping systems were compared : cultivation of J. curcas as a sole crop with and without fertilisers, a combination of J. curcas with subsistence crops (maize - Zea mays L., the common bean - Phaseolus vulgaris L.) with and without fertilisers. The major attacks by pests (mainly Aphthona sp.) suffered by J. curcas plants in the region make it vital to conduct at least two insecticide treatments per year. Dry seed yields of J. curcas obtained in the 4th year of cultivation amounted to 753 kg ha-1 when J. curcas was cultivated as a sole crop without fertilisers, 797 kg ha-1 for intercropping without fertilisers, 1158 kg ha-1 when J. curcas was cultivated as a sole crop with fertilisers and 1173 kg ha-1 for intercropping with fertilisers. Yields from the two annual crops were not improved by the application of mineral fertilisers on the J. curcas plants. They amounted to an average of 815 kg ha-1 for maize and 676 kg ha-1 for the beans. It is more profitable to cultivate J. curcas with maize and beans than to cultivate it as a sole crop. By combining crops in this way, a one-hectare farm can earn 1102 USD ha-1 without fertilisers and 1049 USD ha-1 with fertilisers. Sustainable cultivation of J. curcas under the test conditions requires the development of efficient weed / pest control methods and improved soil fertility management, in order to minimise the use of mineral fertilisers. [less ▲]

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See detailPituitary MRI characteristics in 297 acromegaly patients based on T2-weighted sequences.
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Daly, Adrian ULg et al

in Endocrine-related cancer (2015)

Context: Responses of GH-secreting adenomas to multimodal management of acromegaly varies widely between patients. Understanding the behavioral patterns of GH-secreting adenomas by identifying predictive ... [more ▼]

Context: Responses of GH-secreting adenomas to multimodal management of acromegaly varies widely between patients. Understanding the behavioral patterns of GH-secreting adenomas by identifying predictive factors of their evolution is a research priority. Objective: To clarify the relationship between adenoma T2-weighted signal on diagnostic MRI in acromegaly and clinical and biological features at diagnosis. Design: International, multicenter, retrospective analysis. Setting: 10 endocrine tertiary referral centers. Patients: 297 acromegalic recently diagnosed patients with available diagnostic MRI evaluations were included in the study. Main outcome measure: Clinical, biochemical characteristics and MRI signal findings. Results: T2-hypointense adenomas represented 52.9% of the series, were smaller than their T2-hyper- and isointense counterparts (p<0.0001), were associated with higher IGF1 levels (p=0.0001), invaded the cavernous sinus less frequently (p=0.0002) and rarely caused optic chiasm compression (p<0.0001). Acromegalic men tended to be younger at diagnosis than women (p=0.067) and presented higher IGF1 values (p=0.01). Although in total, adenomas had a predominantly inferior extension in 45.8% of cases, in men this was more frequent (p<0.0001), whereas in women optic chiasm compression of macroadenomas occurred more often (p=0.0067). Most adenomas (45.1%) measured between 11-20mm in maximal diameter and bigger adenomas were diagnosed at younger ages (p=0.0001). Conclusions: T2-weighted signal differentiates GH-secreting adenomas into subgroups with particular behaviors. This raises the question of whether T2-weighted signal could represent a factor in the classification of acromegalic patients in future studies. [less ▲]

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See detailMutation de l'image, mutation de l'intention ? L'impact des représentations numériques en composition architecturale
Cunin, Maxime; Yang, Maria C.; Elsen, Catherine ULg

in de Boissieu, Aurélie; Deshayes, Catherine (Eds.) Actes du colloque "Mutations du Projet - Milieux et Cultures Numériques" (2015)

Les architectes ont toujours eu recours à de multiples représentations pour générer, faire évoluer puis communiquer leurs concepts architecturaux (tant aux pairs qu’aux usagers, ou encore aux décideurs ... [more ▼]

Les architectes ont toujours eu recours à de multiples représentations pour générer, faire évoluer puis communiquer leurs concepts architecturaux (tant aux pairs qu’aux usagers, ou encore aux décideurs). Cet article envisage comment la représentation externe impacte la perception « naïve » d’une intention architecturale, les « non experts » assumant des rôles de plus fondamentaux au sein de certains mécanismes décisionnels. Comment l’image, en pleine mutation depuis l’ère du numérique, façonne-t-elle la perception des facteurs clés (ou « attributs ») d’une intention architecturale ? L’article résume les principaux résultats d’une enquête menée en ligne via l’interface « Amazon Mechanical Turk » et générant 790 échelles d’évaluation de 6 avant-projets architecturaux. Les résultats abordent l’analyse des données en regard des différentes attributs; en regard des trois types de représentation choisies et en regard enfin des inconsistances dont font preuve les architectes eux-mêmes, étant donné l’évaluation de leurs propres projets et représentations. Ils révèlent que les attributs ne sont pas équitablement propices à un transfert d’intention exclusivement graphique et que les formes plus abstraites de représentations constituent, dans certains contextes, le moyen le plus efficace pour le transfert fidèle d’une intention architecturale. [less ▲]

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See detailEfficacy and cost-effectiveness: A study of different treatment approaches in a tertiary pain centre
VANHAUDENHUYSE, Audrey ULg; Gillet, Aline ULg; MALAISE, Nicole ULg et al

in European Journal of Pain (London, England) (2015)

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