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See detailPCR-RFLP identification of the endangered Pyrenean desman, Galemys pyrenaicus (Soricomorpha, Talpidae), based on faecal DNA
Gillet, François ULg; Cabria Garrido, Maria Teresa; Némoz, Mélanie et al

in Mammalia (2014)

The Pyrenean desman is a vulnerable mammal species endemic to Pyrenees and the northern Iberian Peninsula. The presence of this elusive species can be most easily detected by sampling its faeces. However ... [more ▼]

The Pyrenean desman is a vulnerable mammal species endemic to Pyrenees and the northern Iberian Peninsula. The presence of this elusive species can be most easily detected by sampling its faeces. However, these faecal samples can be confused with those of other vertebrate species living in the same habitats. This study provides two easy and reliable methods for the identification of the Pyrenean desman faeces based on genetic analyses. The first one consists of a nested PCR and sequencing of a mitochondrial cytochrome b fragment, and the second one is an enzymatic digestion with endonucleases Alu I and Sau 3AI. The restriction patterns given by the two enzymes were found suitable for the successful discrimination of the Pyrenean desman from the other species based on species-specific sequence variations. [less ▲]

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See detailLa culture, grande absente ou objectif discret de l’agenda post-2015 ?
Vlassis, Antonios ULg

Article for general public (2014)

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See detailEGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP.
Paye, Alexandra ULg; Truong, Alice ULg; Yip, Cassandre ULg et al

in Cancer Research (2014), 74(23), 6758-70

MT4-MMP (MMP-17) is a GPI-anchored matrix metalloprotease expressed on the surface of cancer cells which promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver of ... [more ▼]

MT4-MMP (MMP-17) is a GPI-anchored matrix metalloprotease expressed on the surface of cancer cells which promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver of cancer cell proliferation through CDK4 activation and retinoblastoma protein (Rb) inactivation. We also determine a functional link between MT4-MMP and the growth factor receptor EGFR. Mechanistic experiments revealed direct association of MT4-MMP and its positive effects on EGFR phosphorylation in response to TGF- and EGF in cancer cells. Notably, the effects of MT4-MMP on proliferation and EGFR activation did not rely on metalloprotease activity. Clinically, MT4-MMP and EGFR expression were correlated in human triple negative breast cancer specimens. Altogether our results identify MT4-MMP as a positive modifier of EGFR outside-in signaling that acts to cooperatively drive cancer cell proliferation. [less ▲]

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See detailSquamocolumnar junction cells and HPV infection
Herfs, Michael ULg

Scientific conference (2014, October)

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See detailRole of the progesterone receptor in the development of sexual behavior in female mice
Desroziers, Elodie ULg; Brock, Olivier; Baum, M.J. et al

Conference (2014, October)

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See detailCalibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Cristol, Jean-Paul et al

in Journal of Nephrology (2014), 27(5), 467-75

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay ... [more ▼]

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay used, and calibration standardization is necessary. For SCr, isotope dilution mass spectrometry (IDMS) is the gold standard. Systematic differences are observed between Jaffe and enzymatic methods. Manufacturers subtract 0.30 mg/dl from Jaffe results to match enzymatic results (‘compensated Jaffe method’). The analytical performance of enzymatic methods is superior to that of Jaffe methods. In the original Modification of Diet in Renal Disease (MDRD) equation, SCr was measured by a Jaffe Beckman assay, which was later recalibrated. A limitation of this equation was an underestimation of GFR in the high range. The Chronic Kidney Disease Epidemiology (CKD-EPI) consortium proposed an equation using calibrated and IDMS traceable SCr. The gain in performance was due to improving the bias whereas the precision was comparable. The CKD-EPI equation performs better at high GFR levels (GFR[60 ml/ min/1.73 m2). Analytical limitations have led to the recommendation to give a grade ([60 ml/min/1.73 m2) rather than an absolute value with the MDRD equation. By using both enzymatic and calibrated methods, this cutoff-grade could be increased to 90 ml/min/1.73 m2 (with MDRD) and 120 ml/min/1.73 m2 (with CKD-EPI). The superiority of the CKD-EPI equation over MDRD is analytical, but the precision gain is limited. IDMS traceable enzymatic methods have been used in the development of the Lund– Malmo¨ (in CKD populations) and Berlin Initiative Study equations (in the elderly). The analytical errors for cystatin C are grossly comparable to issues found with SCr. Standardization is available since 2011. A reference method for cystatin C is still lacking. Equations based on standardized cystatin C or cystatin C and creatinine have been proposed. The better performance of these equations (especially the combined CKD-EPI equation) has been demonstrated. [less ▲]

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See detailSinuso-nasal adenocarcinoma in a roe deer (Capreolus capreolus)
Volpe, Rosario ULg; Cassart, Dominique ULg; Neukermans, Axel et al

Poster (2014, October)

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See detailFiscalité et Aménagement du Territoire
Bianchet, Bruno ULg; Xhignesse, Guillaume ULg; Farah, Jihad ULg et al

Report (2014)

Cette recherche consiste en une réflexion sur la fiscalité en tant qu'outil d'aménagement du territoire et en tant que moyen de recontrer les défis du développement territorial, dans le contexte wallon ... [more ▼]

Cette recherche consiste en une réflexion sur la fiscalité en tant qu'outil d'aménagement du territoire et en tant que moyen de recontrer les défis du développement territorial, dans le contexte wallon. Elle s'intègre dans le contexte des débats qui entourent la sixième réforme de l'Etat belge. Elle a pour objectif l'établissement d'un cadre utilisable pour l'évaluation de certains effets territoriaux suite à la mise en oeuvre ou à la modification de politiques fiscales. In fine, elle aboutira à des propositions d'adaptation ou de mise au point de nouvelles mesures en vue de rencontrer les défis territoriaux. Afin d'atteindre ces objectifs, elle se concentre également sur la mise en évidence des liens existants entre le système fiscal en place et certains défis territoriaux. Son objet est restreint au logement et à l'aménagement en lien avec le logement. [less ▲]

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See detailDevenir art-thérapeute
Vandeninden, Elise ULg

in SociologieS (2014)

In the field of mental health workers, a new profession is emerging: animators of art workshops in psychiatry, also called ‘art therapists’. Our paper reveals the results of a survey conducted in Belgium ... [more ▼]

In the field of mental health workers, a new profession is emerging: animators of art workshops in psychiatry, also called ‘art therapists’. Our paper reveals the results of a survey conducted in Belgium among these new professionals. In portraying this new group of ‘distributed’ workers, we will discuss the reasons for their difficult process of professionalization [less ▲]

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See detailHCVerso2: a phase III study of faldaprevir plus deleobuvir and ribavirin for chronic HCV genotype 1b infection in treatment naïve patients including those ineligible for pegylated interferon
Nelson, D; Andreone, P; Colombo, M et al

in Hepatology (Baltimore, Md.) (2014, October), 60(S1),

In treatment-naïve, non-cirrhotic patients with HCV GT1b infection, faldaprevir + deleobuvir + ribavirin for 16 or 24 w resulted in comparable SVR 12 rates (76% vs 82%) with similar tolerability profiles ... [more ▼]

In treatment-naïve, non-cirrhotic patients with HCV GT1b infection, faldaprevir + deleobuvir + ribavirin for 16 or 24 w resulted in comparable SVR 12 rates (76% vs 82%) with similar tolerability profiles. Patients with cirrhosis achieved SVR 12 of 74% (24w). The adjusted SVR rates for 16 or 24w in patients with or without cirrhosis were significantly higher than historical control. [less ▲]

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See detailSwallowing in disorders of consciousness
Bicego, Aminata; Lejoly, Kelly ULg; Maudoux, Audrey et al

in Revue Neurologique (2014), 170(10),

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See detailLe droit des biens. Les droits réels démembrés
Boufflette, Sophie ULg; Salvé, Arianne ULg; Popa, Ruxandra ULg et al

in Chroniques notariales (2014)

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See detailServitudes du fait de l'homme Chronique de jurisprudence 2008-2014
Boufflette, Sophie ULg

in Les droits réels démembrés (2014)

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See detailImpact of intensive enteral nutrition in association with corticosteroïds in the treatment of severe alcoholic hepatitis: a multicenter randomized controlled trial
Moreno, C; Trepo, E; Louvet, A et al

in Hepatology (Baltimore, Md.) (2014, October), 60(S1),

Intensive enteral nutrition by feeding tube does not improve 6-month survival in patients with severe alcoholic hepatitis. However, adequate nutritional support is associated with a better short-term ... [more ▼]

Intensive enteral nutrition by feeding tube does not improve 6-month survival in patients with severe alcoholic hepatitis. However, adequate nutritional support is associated with a better short-term prognosis. Adequate nutritional intake should be targeted in alcoholic hepatitis patients treated with corticosteroids. [less ▲]

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See detailUn laboratoire d’autoimmunité paperless : mythe ou réalité ?
LUTTERI, Laurence ULg

Conference (2014, October)

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See detailWASP-104b and WASP-106b: two transiting hot Jupiters in 1.75-day and 9.3-day orbits
Smith, A. M. S.; Anderson, D. R.; Armstrong, D. J. et al

in Astronomy and Astrophysics (2014)

We report the discovery from the WASP survey of two exoplanetary systems, each consisting of a Jupiter-sized planet transiting an 11th magnitude (V) main-sequence star. WASP-104b orbits its star in 1.75 d ... [more ▼]

We report the discovery from the WASP survey of two exoplanetary systems, each consisting of a Jupiter-sized planet transiting an 11th magnitude (V) main-sequence star. WASP-104b orbits its star in 1.75 d, whereas WASP-106b has the fourth-longest orbital period of any planet discovered by means of transits observed from the ground, orbiting every 9.29 d. Each planet is more massive than Jupiter (WASP-104b has a mass of 1.27±0.05 MJup, while WASP-106b has a mass of 1.93±0.08 MJup). Both planets are just slightly larger than Jupiter, with radii of 1.14±0.04 and 1.09±0.04 RJup for WASP-104 and WASP-106 respectively. No significant orbital eccentricity is detected in either system, and while this is not surprising in the case of the short-period WASP-104b, it is interesting in the case of WASP-106b, because many otherwise similar planets are known to have eccentric orbits. [less ▲]

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See detailOptimization of pAOX1 induction in a methanol/sorbitol co-feeding process in Pichia pastoris
Carly, F.; Niu, H.; Fickers, Patrick ULg

Conference (2014, October)

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