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See detailInternet facilite-t-il un apprentissage de plus en plus auto-déterminé ? Illustrations et réflexions.
Poumay, Marianne ULg

Conference (2014, May 01)

Après avoir introduit le thème du contrôle par l’étudiant de son propre apprentissage, la conférence illustrera des situations d’apprentissage et d’évaluation (bien sûr faisant usage d’Internet) qui ... [more ▼]

Après avoir introduit le thème du contrôle par l’étudiant de son propre apprentissage, la conférence illustrera des situations d’apprentissage et d’évaluation (bien sûr faisant usage d’Internet) qui poussent l’étudiant à faire des choix et qui, en corollaire, aboutissent à faire valider par les enseignants le résultat de trajectoires riches et différenciées. Rassembler des preuves de son développement de compétences, planifier son inscription dans une série de MOOCs ou son travail en ligne suite à un test diagnostique sont autant d’actions qui responsabilisent l’étudiant quant à sa propre formation. Mais l’apprentissage autodéterminé est-il à la portée de tous les étudiants ? [less ▲]

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See detailApproche systémique de l’intégration des TIC dans l’éducation : enjeux, actions et perspectives à l’horizon 2020
Denis, Brigitte ULg

Conference (2014, May 01)

En Belgique francophone, diverses initiatives ont vu le jour durant ces quinze dernières années dans le but de développer un usage réfléchi des TIC en éducation. Parmi celles-ci épinglons les « Plans TIC ... [more ▼]

En Belgique francophone, diverses initiatives ont vu le jour durant ces quinze dernières années dans le but de développer un usage réfléchi des TIC en éducation. Parmi celles-ci épinglons les « Plans TIC", la mise au point d’un curriculum de formation relatif aux usages et aux apports des médias et des TIC en enseignement destiné aux futurs enseignants, la mise en réseau d’enseignants du supérieur, la constitution de communautés d’apprenants supportées par les TIC. Plans d’équipement des écoles, projets-pilotes, formation initiale et continuée des enseignants en matière de TICE, réseaux de partage… convergent vers un même objectif : développer, expérimenter et diffuser des activités d’apprentissage à hautes plus-values. Des scénarios pédagogiques exploitant différents types d’outils/services technologiques et supports (ordinateurs, tablettes, tableaux interactifs…) et leurs plus-values sont mis au point afin de développer les savoirs, savoir-faire et savoir-être des apprenants, non seulement en rapport aux apprentissages scolaires, mais aussi dans l’optique d’un transfert dans la vie quotidienne, citoyenne et professionnelle. Certaines de ces initiatives seront présentées en les situant dans une approche systémique. Nous mettrons l’accent sur ce qui les unit, les facteurs facilitateurs et les obstacles rencontrés lors de leur implémentation sur le terrain et proposerons quelques recommandations. [less ▲]

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See detailPromotion of physical activity in schools
Cloes, Marc ULg

Conference (2014, May 01)

This presentation will answer to the following questions: (1) Does the school play a role in PA promotion? (2) What are the dimensions of PA at school? (3) How to determine the potential role of the ... [more ▼]

This presentation will answer to the following questions: (1) Does the school play a role in PA promotion? (2) What are the dimensions of PA at school? (3) How to determine the potential role of the school in PA promotion? (4) What kind of projects to implement? (5) What do we have to remember? It will be based on an overview of the literature and will provide practical implications for researchers and practitioners. [less ▲]

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See detailThe Transcription Factor EGR1 Localizes to the Nucleolus and Is Linked to Suppression of Ribosomal Precursor Synthesis
Ponti, Donatella; Bellenchi, Gian Carlo; Puca, Rosa et al

in PLoS ONE (2014), 9(5),

EGR1 is an immediate early gene with a wide range of activities as transcription factor, spanning from regulation of cell growth to differentiation. Numerous studies show that EGR1 either promotes the ... [more ▼]

EGR1 is an immediate early gene with a wide range of activities as transcription factor, spanning from regulation of cell growth to differentiation. Numerous studies show that EGR1 either promotes the proliferation of stimulated cells or suppresses the tumorigenic growth of transformed cells. Upon interaction with ARF, EGR1 is sumoylated and acquires the ability to bind to specific targets such as PTEN and in turn to regulate cell growth. ARF is mainly localized to the periphery of nucleolus where is able to negatively regulate ribosome biogenesis. Since EGR1 colocalizes with ARF under IGF-1 stimulation we asked the question of whether EGR1 also relocate to the nucleolus to interact with ARF. Here we show that EGR1 colocalizes with nucleolar markers such as fibrillarin and B23 in the presence of ARF. Western analysis of nucleolar extracts from HeLa cells was used to confirm the presence of EGR1 in the nucleolus mainly as the 100 kDa sumoylated form. We also show that the level of the ribosomal RNA precursor 47S is inversely correlated to the level of EGR1 transcripts. The EGR1 iseffective to regulate the synthesis of the 47S rRNA precursor. Then we demonstrated that EGR1 binds to the Upstream Binding Factor (UBF) leading us to hypothesize that the regulating activity of EGR1 is mediated by its interaction within the transcriptional complex of RNA polymerase I. These results confirm the presence of EGR1 in the nucleolus and point to a role for EGR1 in the control of nucleolar metabolism. [less ▲]

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See detailMDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation.
Shostak, Kateryna ULg; Patrascu, F.; Göktuna, Serkan ULg et al

in Cell death and differentiation (2014), 5(21), 811-24

Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic approach to treat cancer. However, because ... [more ▼]

Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic approach to treat cancer. However, because the MDM2 targetome extends beyond p53, MDM2 inhibition may also cause unwanted activation of oncogenic pathways. Accordingly, we identified the microtubule-associated HPIP, a positive regulator of oncogenic AKT signaling, as a novel MDM2 substrate. MDM2-dependent HPIP degradation occurs in breast cancer cells on its phosphorylation by the estrogen-activated kinase TBK1. Importantly, decreasing Mdm2 gene dosage in mouse mammary epithelial cells potentiates estrogen-dependent AKT activation owing to HPIP stabilization. In addition, we identified HPIP as a novel p53 transcriptional target, and pharmacological inhibition of MDM2 causes p53-dependent increase in HPIP transcription and also prevents HPIP degradation by turning off TBK1 activity. Our data indicate that p53 reactivation through MDM2 inhibition may result in ectopic AKT oncogenic activity by maintaining HPIP protein levels.Cell Death and Differentiation advance online publication, 31 January 2014; doi:10.1038/cdd.2014.2. [less ▲]

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See detailOutplacement adequacy and benefits: The mediating role of retrospective justice
Marzucco, Laurence ULg; Hansez, Isabelle ULg

Poster (2014, May)

ABSTRACT We examined the relationships between perceived outplacement adequacy, retrospective justice and outplacement benefits for redundant employees using outplacement services. Based on an ... [more ▼]

ABSTRACT We examined the relationships between perceived outplacement adequacy, retrospective justice and outplacement benefits for redundant employees using outplacement services. Based on an outplacement experience perceived as adequate, victims formed retrospective justice perceptions about their former organization that in turn, impacted their negative emotions, well-being, future perspectives and job search. PRESS PARAGRAPH The increasing prevalence of organizational downsizing has been matched by growth in the provision of outplacement services over the last decade. Despite this rapid growth and ongoing need for outplacement services, little is yet known about the perceived adequacy and the benefits of these services for redundant employees using them. Our results indicated that an outplacement experience perceived as adequate for redundant employees retrospectively fosters their impressions of justice about the dismissing organization; this leads in turn to satisfactory benefits for them: reduction of negative emotions, enhancement of their perceived well-being, future perspectives, and job-seeking activities. [less ▲]

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See detailEvent justice and social entity justice: A cross-lagged analysis
Marzucco, Laurence ULg; Hansez, Isabelle ULg

Poster (2014, May)

ABSTRACT This study aimed to examine the directionality of the relationship between event justice and social entity justice. Using two samples and a cross-lagged panel analysis with two measurement times ... [more ▼]

ABSTRACT This study aimed to examine the directionality of the relationship between event justice and social entity justice. Using two samples and a cross-lagged panel analysis with two measurement times, social entity justice was found to predict event justice (procedural, distributive, interpersonal and informational justice event), supporting the top-down process. PRESS PARAGRAPH The life of organizations is punctuated by a wide range of managerial decisions (e.g., hiring, performance appraisal or organizational change). Facing such events, employees evaluate the fairness of the situation experienced. However, little is known about how employees develop justice judgments. This study shows that employees’ fairness perceptions about their organization influence their interpretation of the fairness of subsequent events involving the organization. Building and fostering a climate of justice is therefore of primary importance for organizations, since global fairness perceptions about the organization may help employees to perceive a specific event, such as a managerial decision, as being fair. [less ▲]

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See detailAnalyses croisées du monde du travail
Smette, Bernard ULg

in Cahiers du GRM (2014), 5

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See detailProjected inhibition of platelet aggregation with ticagrelor twice daily vs. clopidogrel once daily based on patient adherence data (the TWICE project)
Vrijens, Bernard ULg; Claeys, M.J.; LEGRAND, Victor ULg et al

in British Journal of Clinical Pharmacology (2014), 77(5), 746-755

Abstract Aim Twice daily dosing is often perceived as inferior to once daily dosing due to a higher likelihood of missing a dose. However, more important is the extent to which drug action is maintained ... [more ▼]

Abstract Aim Twice daily dosing is often perceived as inferior to once daily dosing due to a higher likelihood of missing a dose. However, more important is the extent to which drug action is maintained when doses are delayed or missed. We compared the estimated inhibition of platelet aggregation (eIPA) for ticagrelor twice daily and clopidogrel once daily, based on their pharmacokinetic/ pharmacodynamic relationships and patient dosing history data. Methods Drug dosing histories of 5014 patients prescribed cardiovascular medications (primarily antihypertensive medicines) were extracted from an electronically compiled dosing history database. eIPA levels were simulated for 677 twice daily and 677 once daily dosing histories over a 30 day period, based on published onset/offset models for ticagrelor and clopidogrel IPA characteristics. Results While many patients treated twice daily missed at least one dose in 30 days, only 25.7% missed two consecutive doses. By comparison, 46.8% of patients treated once daily missed at least one dose. Simulations based on patient adherence over time showed that the average mean eIPA for ticagrelor twice daily remained significantly higher than for clopidogrel once daily (81.1% vs. 55.0%, P < 0.001). Ticagrelor twice daily patients had an eIPA below 10% for 0.20% of the 30 day period compared with 2.05% for clopidogrel once daily (P = 0.0001). Conclusions The projected level of platelet inhibition remained higher for ticagrelor twice daily than clopidogrel once daily, mainly due to the higher eIPA level achieved with ticagrelor and the relatively low likelihood of missing two consecutive twice daily doses. This modelling and simulation study suggests a therapeutic benefit of ticagrelor over clopidogrel when taking into account the most common dosing omissions. © 2013 The British Pharmacological Society. [less ▲]

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See detailDark Atoms and Dark Radiation
Khlopov, Maxim; Belotsky, Konstantin; Cudell, Jean-René ULg et al

Book published by Hindawi Publishing Corporation (2014)

We have invited investigators to contribute original research and review articles that seek to define the possible physical nature of composite dark matter and its constituents, to stimulate the ... [more ▼]

We have invited investigators to contribute original research and review articles that seek to define the possible physical nature of composite dark matter and its constituents, to stimulate the experimental searches and to suggest astrophysical tests for their effects. The collected papers in this special issue represent only a first small step in the approach to the thorough investigation of the topic of dark atoms and dark radiation, demonstrating the wide but far from complete variety of possible aspects of this problem. [less ▲]

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See detailDes performances de production laitière et de reproduction élevées sont compatibles. Le management en est la clé.
Chapaux, Philippe; Glorieux, Géry; Hanzen, Christian ULg

in Veterinaria (Bruxelles) : Bulletin d’Information de l’Union Syndicale Vétérinaire Belge (2014)

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See detailLe "déplacement" comme problème: les transferts artistiques à l'époque gothique
Van den Bossche, Benoît ULg; Dubois, Jacques; Guillouët, Jean-Marie

in Van den Bossche, Benoît; Dubois, Jacques; Guillouët, Jean-Marie (Eds.) Les transferts artistiques dans l'Europe gothique (2014)

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See detailProcessing of alloy Ti-6Al-4V and of stainless steel 316L by Laser Beam Melting
Mertens, Anne ULg; Paydas, Hakan ULg; Reginster, Sylvie ULg et al

Conference (2014, May)

Additive manufacturing processes such as Selective Laser Melting (SLM) appear very promising in view of the economic production of near-net-shape, complex and (almost) fully dense parts from metallic ... [more ▼]

Additive manufacturing processes such as Selective Laser Melting (SLM) appear very promising in view of the economic production of near-net-shape, complex and (almost) fully dense parts from metallic materials such as Ti alloys and stainless steels. Practically, in SLM, a metallic powder is deposited layer-by-layer in a powder bed and then molten locally according to the desired shape. An important feature of this process is that the structure undergoes an ultra-fast cooling once the beam leaves the working zone, thus giving rise to strongly out-of-equilibrium microstructures. In the case of Ti alloy Ti-6Al-4V, in particular, the microstructural anisotropy resulting from the epitaxial growth of the newly deposited layer on the material previously solidified has been shown to exert a very strong influence on the mechanical properties [1] In the present work, the thermophysical behaviour of Ti-alloy Ti-6Al-4V and of stainless steel 316L has been characterised in details, in order to reach a better understanding of the phenomena controlling the microstructures and mechanical properties of parts. In particular, the thermal conductivity of Ti-alloy Ti-6Al-4V and of stainless steel 316L at high temperature has been determined by combining dilatometry, Differential Scanning Calorimetry (DSC) and laser flash diffusivimetry based on Laplace’s equation. Since Ti-alloy Ti-6Al-4V and stainless steel 316L exhibit quite different physical behaviours, their careful comparison is shown to shed more light into the role of phenomena such as epitaxial growth, out-of-equilibrium phase transformations and/or internal stresses in the additive manufacturing of metallic materials. [less ▲]

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See detailHybrid MicroPET Imaging for Dosimetric Applications in Mice: Improvement of Activity Quantification in Dynamic MicroPET Imaging for Accelerated Dosimetry Applied to 6-[ 18 F] Fluoro- L -DOPA and 2-[ 18 F]Fluoro- L -Tyrosine
Bretin, Florian ULg; Mauxion, T; Warnock, G et al

in Molecular Imaging and Biology (2014), 16(3), 383-394

Purpose: Dynamic microPET imaging has advantages over traditional organ harvesting, but is pronetoquantificationerrorsinsmallvolumes.Hybridimaging,wheremicroPETactivitiesarecross- calibrated using post ... [more ▼]

Purpose: Dynamic microPET imaging has advantages over traditional organ harvesting, but is pronetoquantificationerrorsinsmallvolumes.Hybridimaging,wheremicroPETactivitiesarecross- calibrated using post scan harvested organs, can improve quantification. Organ harvesting, dynamic imaging and hybrid imaging were applied to determine the human and mouse radiation dosimetry of 6-[18 F]fluoro-L-DOPA and 2-[18 F]fluoro-L-tyrosine and compared. Procedures: Two-hour dynamic microPET imaging was performed with both tracers in four separate mice for 18 F-FDOPA and three mice for 18 F-FTYR. Organ harvesting was performed at 2, 5, 10, 30, 60 and 120 min post tracer injection with n=5 at each time point for 18 F-FDOPA and n=3 at each time point for 18 F-FTYR. Human radiation dosimetry projected from animal data was calculated for the three different approaches for each tracer using OLINDA/EXM. S- factors for the MOBY phantom were used to calculate the animal dosimetry. Results: Correlations between dose estimates based on organ harvesting and imaging was improved from r=0.997 to r=0.999 for 18 F-FDOPA and from r=0.985 to r=0.996 (p<0.0001 for all) for 18 F-FTYR by using hybrid imaging. Conclusion: Hybrid imaging yields comparable results to traditional organ harvesting while partially overcoming the limitations of pure imaging. It is an advantageous technique in terms of number of animals needed and labour involved. [less ▲]

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See detailAssurer un développement professionnel au travers de la formation et de l'accompagnement
Pirard, Florence ULg

in Plus de chance dès l'enfance (2014)

L’accueil et l’éducation de jeunes enfants en dehors du cadre familial (en milieu d’accueil, à l’école maternelle, dans l’accueil extrascolaire et les centres de vacances) nécessite des conditions pour ... [more ▼]

L’accueil et l’éducation de jeunes enfants en dehors du cadre familial (en milieu d’accueil, à l’école maternelle, dans l’accueil extrascolaire et les centres de vacances) nécessite des conditions pour l’acquisition de compétences professionnelles et leur développement. L’importance accordée aujourd’hui à une prise en compte des diversités dans l’accueil et l’éducation des jeunes enfants, en particulier celles liées aux situations de précarité, voire de pauvreté, conduit inévitablement à s’interroger sur les compétences professionnelles des divers acteurs opérant dans le secteur (puériculteurs/trices, auxiliaires de l’enfance, accueillant-e-s extrascolaires, enseignant-e-s préscolaires , etc). Quelles compétences clés sont en jeu ? Comment leur formation initiale et continuée les sensibilise à ces enjeux de société ? Quelles conditions permettent le développement des compétences professionnelles dans l’exercice de leur métier ? [less ▲]

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See detailAnalysis of the Shrinkage Effect on Mass Transfer During Convective Drying of Sawdust/Sludge Mixtures
Li, Jie ULg; Bennamoun, Lyes; Fraikin, Laurent ULg et al

in Drying Technology (2014), 32

Convective drying of wastewater sludges and sawdust/sludge mixtures was studied. The first part of this work was an experimental study performed in a cross-flow convective dryer using 500 g of wet ... [more ▼]

Convective drying of wastewater sludges and sawdust/sludge mixtures was studied. The first part of this work was an experimental study performed in a cross-flow convective dryer using 500 g of wet material extruded through a disk with circular dies of 12 mm. The results showed that the sawdust addition has a positive impact on the drying process from a mass ratio of 2/8, on a dry basis, with observed drying rates higher than the original sludge. The second part of this work consisted of developing a drying model in order to identify the internal diffusion coefficient and convective mass transfer coefficient from the experimental data. A comparison was made between fitted drying curves, well represented by the Newton’s model, and the analytical solutions of the diffusion equation applied to a finite cylinder. Variations of dimensional characteristics such as the volume and exchange surface of the sample bed were obtained by X-ray tomography. This technique allowed confirm that shrinkage, which is an important phenomenon occurring during sludge and sawdust/mixture drying, must be taken into account. The results showed that both the internal diffusion coefficient and convective mass transfer coefficient were affected by mixing and sawdust addition. The internal diffusion coefficient changed from 7.77×10-9 m2/s for the original sludge to 7.01×10-9 m2/s for the mixed sludge and then increased to 8.35×10-9 m2/s for the mixture of a mass ratio of 4/6. The convective mass transfer coefficient changed from 9.70×10-8 m/s for the original sludge to 8.67×10-8 m/s for the mixed sludge and then increased to 12.09×10-8 m/s for the mixture of a mass ratio of 4/6. These results confirmed that sawdust addition was beneficial to the sludge drying process as the mass transfer efficiency between the air and material increased. Reinforcing the texture of sludge by adding sawdust can increase the drying rate and decrease the drying time, and then the heat energy supply will be reduced significantly. The study also showed that neglecting shrinkage phenomenon resulted in an overestimation for the internal diffusion coefficient for the convective drying of sludges and sawdust/sludge mixtures. [less ▲]

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See detailA hybrid human-computer approach for large-scale image-based measurements using web services and machine learning
Marée, Raphaël ULg; Rollus, Loïc ULg; Stevens, Benjamin ULg et al

in Proceedings IEEE International Symposium on Biomedical Imaging (2014, May)

We present a novel methodology combining web-based software development practices, machine learning, and spatial databases for computer-aided quantification of regions of interest (ROIs) in large-scale ... [more ▼]

We present a novel methodology combining web-based software development practices, machine learning, and spatial databases for computer-aided quantification of regions of interest (ROIs) in large-scale imaging data. We describe our main methodological choices, and then illustrate the benefits of the approach (workload reduction, improved precision, scalability, and traceability) on hundreds of whole-slide images of biological tissue slices in cancer research. [less ▲]

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See detailSelf-medication in persistent rhinitis: overuse of decongestants in half of the patients.
Mehuys, Els; Gevaert, Philippe; Brusselle, Guy et al

in Journal of Allergy and Clinical Immunology - In Practice (2014), 2(3), 313-319

BACKGROUND: Patients with rhinitis often self-medicate with over-the-counter drugs, however this self-treating population has remained largely unstudied. OBJECTIVE: To characterize individuals self ... [more ▼]

BACKGROUND: Patients with rhinitis often self-medicate with over-the-counter drugs, however this self-treating population has remained largely unstudied. OBJECTIVE: To characterize individuals self-medicating persistent rhinitis and to determine the prevalence of and risk factors for intranasal decongestant overuse within this population. METHODS: A cross-sectional observational study of individuals self-medicating persistent rhinitis (defined according to the Allergic Rhinitis and its Impact on Asthma guidelines). Participants (n = 895) completed a self-administered questionnaire to assess current symptoms, rhinitis medication, and previous physician diagnosis. Intranasal decongestant overuse was defined as daily use for at least 1 year. RESULTS: The vast majority of subjects (95%) had moderate-to-severe rhinitis. Nasal congestion was the predominant symptom (median visual analog scale, 6.6 cm; interquartile range, 3.4 cm). Sixty-five percent had had their current nasal problems for more than 5 years. Approximately 80% had a physician diagnosis (mainly allergic rhinitis or rhinosinusitis). The prevalence of intranasal decongestant overuse was high (49%), despite the fact that most of the patients (80%) were educated about the limit on duration of use. Use of intranasal glucocorticosteroids was inversely related to being an overuser (odds ratio 0.24 [95% CI, 0.17-0.35]). The risk of intranasal decongestant overuse also was reduced by use of other medications (oral H1 antihistamines and decongestants), use of nasal saline solution, and more symptoms of itchy and/or runny eyes or colored mucus. Risk was increased by a more severely blocked nose, longer duration of symptoms, the presence of sleep disturbance, higher body mass index, and previous advice to limit the duration of intranasal decongestant use. CONCLUSION: Half of the individuals self-medicating persistent rhinitis overused intranasal decongestants, despite the fact that they were educated about the limit on duration of use. [less ▲]

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