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See detailAccompagner les etudiants infirmiers en stage: enjeux et defis
Dury, Cécile ULg

Conference (2013, November 21)

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See detailL'étude des sémiochimiques. Applications en écologie chimique
Heuskin, Stéphanie ULg

Scientific conference (2013, November 21)

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See detailBio-inspired polymers for the functionalization of surfaces by green processes
Detrembleur, Christophe ULg

Conference (2013, November 20)

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See detailUse of supercritical carbon dioxide to prepare drug-loaded polymer implants
Champeau, Mathilde; Tassaing, Thierry; Thomassin, Jean-Michel ULg et al

Conference (2013, November 20)

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See detailLes semences non-industrielles : une hétérogénéité de pratiques mettant en cause le fixisme
Hecquet, Corentin ULg

in Les semences non-industrielles : une hétérogénéité de pratiques mettant en cause le fixisme (2013, November 20)

Les débats concernant les semences occupent depuis quelques années l’espace public. Se centrer sur cet objet permet de comprendre comment se construit une critique par des discours (dénonciation) et des ... [more ▼]

Les débats concernant les semences occupent depuis quelques années l’espace public. Se centrer sur cet objet permet de comprendre comment se construit une critique par des discours (dénonciation) et des pratiques (proposition). Ces enjeux scientifiques s’inscrivent dans une perspective agroécologique (Stassart, Baret et al. 2012). La critique porte sur le processus de désappropriation des semences et des connaissances et s’inscrit dans le paradigme productiviste (Bonneuil C. , Demeulenaere E. et al. 2006). Ma question de recherche au sujet des différentes constructions de qualification des semences non industrielles se fonde sur mes lectures reprises dans un état des lieux (partie 1). Par semences non industrielles j’entends celles qui ne sont pas inscrites dans une perspective productiviste. Afin de décrypter, j’utilise un cadre analytique constitué de trois catégories questions (la caractérisation ; les modes organisationnels et de circulation ; le positionnement juridico-politique). Ce cadre offre une lecture des tensions et synergies au sein de chacun des cas repris dans la deuxième partie (Kaol Kohz ; Kokopelli ; Semailles ; Bionatur). Leur hétérogénéité balise les cas d’étude. Ils offrent à comprendre les différentes stratégies développées par les pratiques des porteurs de projet, elles vont de l’utilisation du dispositif déployé par le régime semencier à la désobéissance en vue de qualifier leurs semences. Il est également nécessaire de comprendre comment chacun des projets parvient à chercher/maintenir sa proposition. Ce papier ambitionne non à présenter des résultats, mais plutôt comment produire des résultats sur cette question. [less ▲]

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See detailjob day
Bruyère, Eric ULg

Speech (2013)

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See detailRheological characterization of double thermo-responsive block copolymer hydrogels
Thomassin, Jean-Michel ULg; Mathieu, Kevin ULg; Kermagoret, Anthony ULg et al

Poster (2013, November 20)

The ability of double thermoresponsive block copolymers to form hydrogels has been thoroughly studied by rheology. These copolymers having two discrete LCSTs were synthesized following a one-pot strategy ... [more ▼]

The ability of double thermoresponsive block copolymers to form hydrogels has been thoroughly studied by rheology. These copolymers having two discrete LCSTs were synthesized following a one-pot strategy based on the sequential cobalt mediated radical polymeryzation of N-vinylcaprolactam (NVCL) followed by the copolymerization of N-vinylpyrrolidone (NVP) with the residual NVCL.Moreover, the very efficient cobalt mediated radical coupling of the growing chains was advantageously used to design triblock copolymers with similar morphological characteristics than the diblock copolymers (same external block length, copolymer ratio…) allowing direct comparison between their respective gels to be established. Different parameters have been compared such as the block length and the copolymer concentration. Temperature ramps were first performed to distinguish the different states, i.e., solubilized copolymers (below the two LCSTs), micelles (between the two LCSTs) and precipitated polymers (above the two LCSTs). [less ▲]

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See detailSwitching to the Dark Side: Repositioning of Polyglutamine Repeat Promotes Amyloid Fibril Formation by the Model Protein, β-Lactamase BlaP
Thorn, David ULg; Pain, Coralie ULg; Scarafone, Natacha et al

Conference (2013, November 20)

Background: The expansion of polyglutamine (polyQ) repeats is associated with an increased propensity of the protein to aggregate into amyloid fibrils. There are ten human proteins presently known within ... [more ▼]

Background: The expansion of polyglutamine (polyQ) repeats is associated with an increased propensity of the protein to aggregate into amyloid fibrils. There are ten human proteins presently known within which polyQ expansion above a threshold length, e.g. 35-50 residues, leads to ten distinct neurodegenerative disorders [1], the most well-known being Huntington’s disease. While repeat length, aggregation, and disease are well correlated, recent studies suggest the non-polyQ regions of these proteins can also play a significant role, both preventative and facilitative, in the aggregation process. With the aim of exploring this role in more detail, we have engineered chimeric proteins via the insertion of polyQ repeats of various length (23, 30, 55, 79 Q) into two sites of antibiotic resistance enzyme BlaP β-lactamase from Bacillus licheniformis 749/C [2]. Questions addressed: How does polyQ repeat position affect the structure, stability and aggregation of polyQ proteins? Methods: Aggregation kinetics determined by monitoring the decrease in soluble protein fraction over time. Aggregate morphology examined by transmission electron microscopy. Protein stability derived from thermal or chemical unfolding transitions monitored by far-UV CD and intrinsic fluorescence. Results and discussion: PolyQ insertion at either of the two positions led to a decrease in thermodynamic stability that was largely independent of polyQ length. Chimeras with polyQ insertions at position 216 were destabilised to a much greater extent than those with insertions at position 197. The reduced stability of the 216 chimeras was associated with an increased aggregation propensity: (i) the minimum polyQ length leading to aggregation was lower, and (ii) the aggregation rate was significantly higher than that observed by 197 chimeras with equivalent polyQ lengths. Remarkably, the two sites of polyQ insertion are indeed very similar, both residing within flexible loop regions between stable α-helices. Moreover, the 216 chimeras exhibited a higher aggregation propensity than their 197 counterparts even under denaturing conditions, suggesting the disparity between the two chimeras cannot be accounted for by structural differences alone. These findings highlight the strong and complex influence of the overall protein context on polyQ-mediated aggregation. The molecular basis for the observed changes in stability and aggregation propensity is the subject of on-going work. [less ▲]

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See detailLa médiation scolaire : contexte sociologique et paysage actuel en Fédération Wallonie-Bruxelles
Dethier, Baptiste ULg

Conference given outside the academic context (2013)

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See detailDesign of macroporous poly(ionic liquid)s by CO2/water emulsion templated polymerization
Boyère, Cédric ULg; Favrelle, Audrey; Boury, Frank et al

Poster (2013, November 20)

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See detailReversibly cross-linked polymer micelle as smart drug dellivery device
Lecomte, Philippe ULg; Riva, Raphaël ULg; Cajot, Sébastien et al

Conference (2013, November 20)

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See detailCombinaison d'informations génomiques, phénotypiques et généalogiques
Vandenplas, Jérémie ULg; Gengler, Nicolas ULg

Conference given outside the academic context (2013)

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See detailCommon resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury
Williams, Shawniqua; Conte, Mary; Goldfine, Andrew et al

in eLife (2013)

Zolpidem produces paradoxical recovery of speech, cognitive and motor functions in select subjects with severe brain injury but underlying mechanisms remain unknown. In three diverse patients with known ... [more ▼]

Zolpidem produces paradoxical recovery of speech, cognitive and motor functions in select subjects with severe brain injury but underlying mechanisms remain unknown. In three diverse patients with known zolpidem responses we identify a distinctive pattern of EEG dynamics that suggests a mechanistic model. In the absence of zolpidem, all subjects show a strong low frequency oscillatory peak ∼6–10 Hz in the EEG power spectrum most prominent over frontocentral regions and with high coherence (∼0.7–0.8) within and between hemispheres. Zolpidem administration sharply reduces EEG power and coherence at these low frequencies. The ∼6–10 Hz activity is proposed to arise from intrinsic membrane properties of pyramidal neurons that are passively entrained across the cortex by locally-generated spontaneous activity. Activation by zolpidem is proposed to arise from a combination of initial direct drug effects on cortical, striatal, and thalamic populations and further activation of underactive brain regions induced by restoration of cognitively-mediated behaviors. [less ▲]

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See detailContribution to the study of acoustic communication in two Belgian river bullheads (Cottus rhenanus and C. perifretum) with further insight into the sound-producing mechanism
Colleye, Orphal ULg; Ovidio, Michaël ULg; Salmon, André et al

in Frontiers in Zoology (2013), 10(71),

Background: The freshwater sculpins (genus Cottus) are small, bottom-living fishes widely distributed in North America and Europe. The taxonomy of European species has remained unresolved for a long time ... [more ▼]

Background: The freshwater sculpins (genus Cottus) are small, bottom-living fishes widely distributed in North America and Europe. The taxonomy of European species has remained unresolved for a long time due to the overlap of morphological characters. Sound production has already been documented in some cottid representatives, with sounds being involved in courtship and agonistic interactions. Although the movements associated with sound production have been observed, the underlying mechanism remains incomplete. Here, we focus on two closely related species from Belgium: C. rhenanus and C. perifretum. This study aims 1) to record and to compare acoustic communication in both species, 2) to give further insight into the sound-producing mechanism and 3) to look for new morphological traits allowing species differentiation. Results: Both Cottus species produce multiple-pulsed agonistic sounds using a similar acoustic pattern: the first interpulse duration is always longer, making the first pulse unit distinct from the others. Recording sound production and hearing abilities showed a clear relationship between the sound spectra and auditory thresholds in both species: the peak frequencies of calls are around 150 Hz, which corresponds to their best hearing sensitivity. However, it appears that these fishes could not hear acoustic signals produced by conspecifics in their noisy habitat considering their hearing threshold expressed as sound pressure (~ 125 dB re 1 ␣Pa). High-speed video recordings highlighted that each sound is produced during a complete back and forth movement of the pectoral girdle. Conclusions: Both Cottus species use an acoustic pattern that remained conserved during species diversification. Surprisingly, calls do not seem to have a communicative function. On the other hand, fish could detect substrate vibrations resulting from movements carried out during sound production. Similarities in temporal and spectral characteristics also suggest that both species share a common sound-producing mechanism, likely based on pectoral girdle vibrations. From a morphological point of view, only the shape of the spinelike scales covering the body allows species differentiation. [less ▲]

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See detailExploring PNS in Fabry disease
WANG, François-Charles ULg; BOUQUIAUX, Olivier ULg

Scientific conference (2013, November 19)

Detailed reference viewed: 9 (2 ULg)