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See detailUntangling glycaemia and mortality in critical care
Uyttendaele, Vincent ULiege; Dickson, Jennifer L.; Shaw, Geoffrey M. et al

in Critical Care (2017), 21(1), 152

Background: Hyperglycaemia is associated with adverse outcomes in the intensive care unit, and initial studies suggested outcome benefits of glycaemic control (GC). However, subsequent studies often ... [more ▼]

Background: Hyperglycaemia is associated with adverse outcomes in the intensive care unit, and initial studies suggested outcome benefits of glycaemic control (GC). However, subsequent studies often failed to replicate these results, and they were often unable to achieve consistent, safe control, raising questions about the benefit or harm of GC as well as the nature of the association of glycaemia with mortality and clinical outcomes. In this study, we evaluated if non-survivors are harder to control than survivors and determined if glycaemic outcome is a function of patient condition and eventual outcome or of the glycaemic control provided. Methods: Clinically validated, model-based, hour-to-hour insulin sensitivity (SI) and its hour-to-hour variability (%ΔSI) were identified over the first 72 h of therapy in 145 patients (119 survivors, 26 non-survivors). In hypothesis testing, we compared distributions of SI and %ΔSI in 6-hourly blocks for survivors and non-survivors. In equivalence testing, we assessed if differences in these distributions, based on blood glucose measurement error, were clinically significant. Results: SI level was never equivalent between survivors and non-survivors (95% CI of percentage difference in medians outside ±12%). Non-survivors had higher SI, ranging from 9% to 47% higher overall in 6-h blocks, and this difference became statistically significant as glycaemic control progressed. %ΔSI was equivalent between survivors and non-survivors for all 6-hourly blocks (95% CI of difference in medians within ±12%) and decreased in general over time as glycaemic control progressed. Conclusions: Whereas non-survivors had higher SI levels, variability was equivalent to that of survivors over the first 72 h. These results indicate survivors and non-survivors are equally controllable, given an effective glycaemic control protocol, suggesting that glycaemia level and variability, and thus the association between glycaemia and outcome, are essentially determined by the control provided rather than by underlying patient or metabolic condition. [less ▲]

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See detailLe contrôle du respect des droits fondamentaux de ses condamnés par la Cour pénale internationale : théorie et pratique naissante
Deprez, Christophe ULiege

Conference (2017, June 23)

Cette présentation PowerPoint a servi de support à une communication orale dans le cadre de l'édition 2017 de la Conférence des Assistants en droit de Belgique (ACCA), organisée le 23 juin 2017 par l ... [more ▼]

Cette présentation PowerPoint a servi de support à une communication orale dans le cadre de l'édition 2017 de la Conférence des Assistants en droit de Belgique (ACCA), organisée le 23 juin 2017 par l'Université de Liège. [less ▲]

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See detailGreen Biotechnology in Belgium: The Ghent Innovation District.
Segers, Jean Pierre ULiege

E-print/Working paper (2017)

This contribution explores the long-standing evolution of the green biotechnology cluster in the bioRegion of Flanders (Belgium), in particular in the Ghent innovation district.

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See detailQuatre années d'un chantier au XVIe siècle : la façade méridionale de la collégiale Saint-Martin de Liège
Joly, Emmanuel ULiege

Conference (2017, June 23)

Bien que peu étudiée jusqu'ici, la reconstruction de la collégiale Saint-Martin est une des entreprises monumentales majeures du XVIe siècle à Liège. Le bâti et les archives conservées permettent d ... [more ▼]

Bien que peu étudiée jusqu'ici, la reconstruction de la collégiale Saint-Martin est une des entreprises monumentales majeures du XVIe siècle à Liège. Le bâti et les archives conservées permettent d'appréhender, parfois avec précision, la chronologie et les modalités de la reconstruction de cette église. Ainsi, au chantier du chœur, dont la première pierre est posée en 1511, succède le chantier du transept et de la nef, qui fait l'objet d'un contrat signé en 1539 entre le chapitre et le maître maçon Paul de Richelle. Dans cette communication, nous proposons un focus sur les quatre premières années du chantier de la nef et du transept. La période située entre 1539 et 1543 constitue en effet un moment riche en événements clefs. En mars 1540, le chapitre de la collégiale demande explicitement à ce que la façade sud de l'église soit construite en priorité. En plus de nous fournir les motivations esthétiques et pratiques de ce choix, la décision prise par les chanoines nous permet de circonscrire avec précision les travaux qui sont entamés dans un premier temps, et ainsi de pouvoir les analyser finement. De plus, cette première phase est marquée par le décès tragique de Paul de Richelle en 1541, ainsi que par l'implication dans le chantier d'une des personnalités majeures du milieu de la construction en vallée mosane. Cette communication aura donc pour but de mettre en lumière le déroulement du chantier, d'en présenter les acteurs majeurs et de mettre au jour les nombreux changements qui se sont produits dans l'intervalle de ces quatre années. En mettant en relation les données archivistiques, dont la plupart sont inédites, avec les données acquises grâce à l'étude du bâti, nous analyserons l'impact de l'ensemble de ces éléments, tant sur l'organisation du chantier que sur les choix formels et esthétiques. [less ▲]

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See detailCassava Mosaic and Brown Streak Diseases: Current Perspectives and Beyond
Rey, M.E.C.; Vanderschuren, Hervé ULiege

in Annual Review of Virology (2017), 4

Cassava is the fourth largest source of calories in the world but is subject to economically important yield losses due to viral diseases, including cassava brown streak disease and cassava mosaic disease ... [more ▼]

Cassava is the fourth largest source of calories in the world but is subject to economically important yield losses due to viral diseases, including cassava brown streak disease and cassava mosaic disease. Cassava mosaic disease occurs in sub-Saharan Africa and the Asian subcontinent and is associated with nine begomovirus species, whereas cassava brown streak disease has to date been reported only in sub-Saharan Africa and is caused by two distinct ipomovirus species. We present an overview of key milestones and their significance in the understanding and characterization of these two major diseases as well as their associated viruses and whitefly vector. New biotechnologies offer a wide range of opportunities to reduce virus-associated yield losses in cassava for farmers and can additionally enable the exploitation of this valuable crop for industrial purposes. This review explores established and new technologies for genetic manipulation to achieve desired traits such as virus resistance. [less ▲]

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See detailLes directeurs de prison et le savoir: objet et sens d'une recherche
Dubois, Christophe ULiege

Scientific conference (2017, June 23)

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See detailLes rouleaux littéraires coptes de papyrus (fin du IIIe - VIIe siècle)
Carlig, Nathan ULiege

Conference (2017, June 23)

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See detailL'intelligence économique, l'autre capital des entreprises
Leroy, Patrick ULiege

Scientific conference (2017, June 23)

Gestion de l'infirmation et de la connaissance aux sein des entreprises

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See detailOne-step hydrothermal synthesis and electrochemical performance of sodium-manganese-iron phosphate as cathode material for Li-ion batteries
Karegeya, Claude ULiege; Mahmoud, Abdelfattah ULiege; Vertruyen, Bénédicte ULiege et al

in Journal of Solid State Chemistry (2017), 253

The sodium-manganese-iron phosphate Na2Mn1.5Fe1.5(PO4)3 (NMFP) with alluaudite structure was obtained by a one-step hydrothermal synthesis route. The physical properties and structure of this material ... [more ▼]

The sodium-manganese-iron phosphate Na2Mn1.5Fe1.5(PO4)3 (NMFP) with alluaudite structure was obtained by a one-step hydrothermal synthesis route. The physical properties and structure of this material were obtained through XRD and Mössbauer analyses. X-ray diffraction Rietveld refinements confirm a cationic distribution of Na+ and presence of vacancies in A(2)’, Na+ and small amounts of Mn2+ in A(1), Mn2+ in M(1) , 0.5 Mn2+ and Fe cations (Mn2+,Fe2+ and Fe3+) in M(2), leading to the structural formula Na2Mn(Mn0.5Fe1.5)(PO4)3. The particles morphology was investigated by SEM. Several reactions with different hydrothermal reaction times were attempted to design a suitable synthesis protocol of NMFP compound. The time of reaction was varied from 6 to 48 hours at 220°C. The pure phase of NMFP particles was firstly obtained when the hydrothermal reaction of NMFP precursors mixture was maintained at 220°C for 6 hours. When the reaction time was increased from 6 to 12, 24 and 48 hours, the dandelion structure was destroyed in favor of NMFP micro-rods. The combination of NMFP (NMFP-6H, NMFP-12H, NMFP-24H and NMFP-48H) structure refinement and Mössbauer characterizations shows that the increase of the reaction time leads to the progressive increment of Fe(III) and the decrease of the crystal size. The electrochemical tests indicated that NMFP is a 3 V sodium intercalating cathode. The comparison of the discharge capacity evolution of studied NMFP electrode materials at C/5 current density shows different capacities of 48, 40, 34 and 34 mAhg-1 for NMFP-6H, NMFP-12H, NMFP-24H and NMFP-48H respectively. Interestingly, all samples show excellent capacity retention of about 99 % during 50 cycles. [less ▲]

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See detailLes valeurs et le droit : réflexions à partir du droit des pensions
Detienne, Quentin ULiege

Scientific conference (2017, June 23)

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See detailDisease detection and management at the wildlife-livestock-human interface
Chaber, Anne-Lise ULiege

Doctoral thesis (2017)

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See detailEffect of N-acetylcysteine on pain in daily life in patients with sickle cell disease: a randomised clinical trial
Sins, JWR; Fijnvandraat, K; Rijneveld, AW et al

in British Journal of Haematology (2017)

Detailed reference viewed: 9 (0 ULiège)
See detailCarrières et biodiversité : l’intérêt d’une évaluation des services écosystémiques
Dufrêne, Marc ULiege; Mercken, Kathleen ULiege

Conference given outside the academic context (2017)

Detailed reference viewed: 17 (3 ULiège)
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See detailLatest results with LBTI's Vortex coronagraph: real-time tip/tilt sensing, new data reduction algorithms, and YSO observations
Defrere, Denis ULiege; Hinz, Philip; Absil, Olivier ULiege

Conference (2017, June 23)

Vortex coronagraphs are among the most promising solutions to perform high contrast imaging at small angular separations from bright stars. They enhance the dynamic range at very small inner working angle ... [more ▼]

Vortex coronagraphs are among the most promising solutions to perform high contrast imaging at small angular separations from bright stars. They enhance the dynamic range at very small inner working angle (down to the diffraction limit of the telescope) and provide a clear 360 degree discovery space for high-contrast direct imaging of exoplanets. In 2013, we installed and commissioned an L-band coronagraph in LBTI/LMIRCam and obtained outstanding images of the four planets around HR8799 during the first hours on sky. In this presentation, we will present the results of the latest data reduction performed with the VIP software that is developed at the University of Liège and that features state-of-the-art image processing algorithms inherited from the field of background subtraction in computer vision (including machine learning algorithms and low rank modeling algorithms). We will also present the results obtained with the second L- and M-band coronagraph that was recently installed in LMIRCam to enable binocular Vortex observations. During the first observations (October 2016), we tested and validated a new real-time post-coronagraphic tip-tilt sensing technique (called QACITS) to quickly align each beam on the center of their respective Vortex coronagraph and obtained observations of a young star showing disk features near the resolution limit of each aperture. Finally, we will present some exciting prospects for the Vortex coronagraph that will be installed on VISIR and ELT/METIS. [less ▲]

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See detailLa comparaison en Belgique
Delville, Michel ULiege

Conference (2017, June 22)

Detailed reference viewed: 18 (1 ULiège)
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See detailUHPLC-ESI-MS/MS quantitation of natural estrogens in aqueous matrices as pyridine-3-sulfonyl derivatives
Glineur, Alex ULiege; Ronkart, Sébastien; Nott, Kathérine et al

Conference (2017, June 22)

Natural estrogens (estrone: E1, 17-β-estradiol : E2, estriol : E3) and synthetic estrogen (17-α-ethinylestradiol: EE2) are powerful endocrine disruptors. They may have deleterious effects on aquatic ... [more ▼]

Natural estrogens (estrone: E1, 17-β-estradiol : E2, estriol : E3) and synthetic estrogen (17-α-ethinylestradiol: EE2) are powerful endocrine disruptors. They may have deleterious effects on aquatic wildlife and also humans even at extremely low concentrations. For this reason, these molecules have been included in a watch list from the European Commission regarding emerging aquatic pollutants. The maximum detection limits are set at 0.035 and 0.40 ng/L for EE2 and E1, E2 respectively. Reaching such low levels of concentration of estrogenic compounds is a challenge, even using state-of-the-art analytical methods. In this study, we developed a UHPLC-ESI-MS/MS method allowing the quantification of E1, E2, E3 and EE2 residues in aqueous matrices. Studies commonly used ESI in negative mode albeit the poor ionization efficiency of native estrogenic compounds in this mode. In this study, the molecules were derivatised using a sulfonyl chloride reagent (pyridine-3-sulfonyl, P-3-S). The resulting response in the positive mode was significantly enhanced. Similarly to other dansyl derivatives, the product ion spectra of the P-3-S derivatives indicate ions originating from the derivatization reagent moiety. Moreover, several other ions were included in the product ion spectra of the P-3-S derivatives. Their specificity was assessed by a qualitative approach implying the analysis of different types of water samples (groundwater, surface water). Some product ions were found to be noticeably better for quantification and confirmation of the analytes. The developed analytical method was validated according to the NF T90-210 norm which is suitable to assess the performances of a method in the water quality field. The limits of quantification were 0.04, 0.05, 0.10 and 0.02 ng/L in groundwater and 0.89, 0.79,4.42 and 0.29 ng/L in surface water for E1, E2, E3 and EE2 respectively. [less ▲]

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See detailImprovement of the ChIP-seq technique for histone posttranslational modifications through enhanced laboratory protocols and data processing methods
Laczik, Miklos ULiege

Doctoral thesis (2017)

Massively parallel sequencing has rapidly become the dominant technique in various omics studies as it provides an unequalled amount of high quality quantitative data for a reasonable cost that is ... [more ▼]

Massively parallel sequencing has rapidly become the dominant technique in various omics studies as it provides an unequalled amount of high quality quantitative data for a reasonable cost that is decreasing ever since the first next generation sequencers appeared. Subsequently, chromatin immunoprecipitation coupled with massively parallel sequencing (ChIP-seq) is the prevailing method of choice for investigating protein–DNA interactions in a genome-wide manner. Bioinformatics tools are also evolving quickly to meet the increasing demands of processing huge amounts of ChIP-seq data and to open the way for novel techniques and insights. However areas still exist that could benefit from improved wet-lab and dry-lab methods. One such area is data visualisation and interpretation; another is the ChIP-seq study of histone posttranslational modifications, especially the research of inactive histone marks which tend to produce diffuse broad enrichments instead of point-source peaks. Achieving proper enrichment and unbiased analysis in such histone mark studies proves to be a great challenge. In this doctoral thesis we show how we addressed these issues on both the level of bioinformatics and the level of sample processing methods. We present our innovative analysis tools we developed to this end, among others a highly customisable, feature rich viewer for next generation sequencing data visualisation, and an analysis pipeline specifically aimed to handle broad enrichments from ChIP-seq studies of (inactive) histone marks. We propose specific software and specific peak calling settings to detect a range of histone modifications accurately, and we describe the way to determine the optimal settings. Along the pipeline we also present a protocol designed to enhance enrichments and facilitate peak detection in broad peak studies typical of inactive histone marks. We demonstrate how this method affects various enrichment types and propose potential applications that could benefit from it. Furthermore we show diverse achievements with the analysis pipeline, including the interpretation of the aforementioned wet-lab method, and the development of an automated ChIP-seq protocol optimised for low cell numbers. [less ▲]

Detailed reference viewed: 25 (3 ULiège)