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See detailPelouses calcaires : une application de la portance écologique pour le renforcement du réseau écologique
Hendrickx, Sébastien ULg; Van Der Kaa, Claire ULg; Sérusiaux, Emmanuël ULg

in Notes de recherche - Conférence Permanente du Développement Territorial Région Wallonne (2014), 48

La méthodologie d’évaluation de la portance écologique du territoire a ensuite été paramétrée afin d'objectiver l’intérêt du territoire wallon du point de vue des pelouses calcaires. Il résulte de cette ... [more ▼]

La méthodologie d’évaluation de la portance écologique du territoire a ensuite été paramétrée afin d'objectiver l’intérêt du territoire wallon du point de vue des pelouses calcaires. Il résulte de cette application un outil cartographique qui permet de discriminer les sites potentiels les plus efficaces pour la restauration de ces pelouses sur le plan écologique. Cet exercice démontre ainsi très concrètement l'utilité de la portance écologique en tant qu'aide à la décision pour orienter les dépenses de préservation de leur réseau écologique spécifique. [less ▲]

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See detailINCIDENCE AND RISK FACTORS FOR EARLY RENAL DYSFUNCTION AFTER LIVER TRANSPLANTATION
WIESEN, Patricia ULg; Georganta, E; VAN CAUWENBERGE, Isabelle ULg et al

in Intensive Care Medicine (2014, October), 40(S1), 1740628

INTRODUCTION. Renal dysfunction often occurred after liver transplantation. OBJECTIVES. The aim of the study was to determine its incidence and its risk factors in a clinical series at the University ... [more ▼]

INTRODUCTION. Renal dysfunction often occurred after liver transplantation. OBJECTIVES. The aim of the study was to determine its incidence and its risk factors in a clinical series at the University Hospital of Liege, Belgium. METHODS. Orthotopic liver transplantations performed from January 2006 until Sep- tember 2012 were retrospectively reviewed (n = 187). Patients, with no renal replacement therapy (RRT) before transplantation were classified in four groups according to their highest creatinine plasma level during the first postoperative week. First group had a cre- atinine level below 12 mg/l, the second group between 12 and 20 mg/l, the third group between 20 and 35 mg/l, and the fourth above 35 mg/l. In addition, patients who needed RRT during the first week after transplantation were also classified in the fourth group. Preoperative and perioperative parameters were tested as risk factors: age, sex, body mass index (BMI), length of hospital preoperative stay, prior bacterial infection within one month, preoperative ascites, preoperative treatment with ß-blocker, converting enzyme inhibitor, or non steroidal antiinflammatory drugs, preoperative creatinine and bilirubine level, postop- erative lactate level, need for postoperative vasopressive drugs, surgical revision, mechanical ventilation for more than 24 h, postoperative peaks in bilirubine and transam- inase levels, postoperative hemoglobin level, amount of perioperative blood transfusions, type of immunosuppression. Univariate and multivariate analysis were performed using logistic ordinal regression method. RESULTS. There were 78 patients in group 1 (41.7 %), 46 in group 2 (24.6 %), 38 in group 3 (20.3 %) and 25 in group 4 (13.4 %). Eighteen patients required RRT: 13 (7 %) during the first week after transplantation (group 4), the 5 others after the first week after transplan- tation (2 in group 1 and 2, and 1 in group 3). There were 7 (3.7 %) early deaths within 28 days after transplantation. Using univariate analysis, the severity of renal dysfunction was correlated with presence of ascites and prior bacterial infection, preoperative bilirubin and creatinine level, need for surgical revision, use of vasopressor, postoperative mechanical ventilation, postoperative bilirubine, transaminase, and hemoglobin levels. The need for transfusion of each type of products also affected renal dysfunction. The ordinal logistic analysis pointed out the BMI (OR = 1.1, p = 0.004), preoperative creatinine level (OR = 11.1, p \ 0.0001), use of vasopressor (OR = 3.31, p = 0.0002), maximal postop- erative bilirubine level (OR = 1.44, p = 0.044) and minimal postoperative hemoglobin level (OR 0.059 p = 0.0005). CONCLUSIONS. More than half of liver transplanted patients experienced some degree of early renal dysfunction after transplantation. Risk factors are preoperative renal dysfunction, and mainly perioperative circulatory instability requiring the use of vasopressor and post- operative anemia. [less ▲]

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See detailLes Lignées Climaciques de Wallonie
Hendrickx, Sébastien ULg; Van Der Kaa, Claire ULg

Book published by CPDT (2014)

En lien direct avec la cartographie des climax écosystémiques de la wallonie, réalisée dans le cadre de la recherche d'initiative I4 CPDT ayant pour thème "la biodiversité sous l'angle des dynamiques ... [more ▼]

En lien direct avec la cartographie des climax écosystémiques de la wallonie, réalisée dans le cadre de la recherche d'initiative I4 CPDT ayant pour thème "la biodiversité sous l'angle des dynamiques écosystémiques co-évolutive", cet ouvrage facilite la lecture de celle-ci et la rend opérationnelle. Il rassemble une série de fiches, une par lignée climacique identifiée par la cartographie des climax, qui décrivent ces lignées sur le plan biologique mais également en terme d'occupation et d'affectation du territoire. Elles donnent en outre une analyse de la situation existante pour chaque lignée et des recommandations par rapport aux mesures à mettre en oeuvre pour améliorer celle-ci. [less ▲]

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See detailValidation des paramètres de marche par un système accélérométrique (Locométrix*) à l'aide d'un système opto-électronique 3D (Coda Motion )
GILLAIN, Sophie ULg; Schwartz, Cédric ULg; Boutaayamou, Mohamed ULg et al

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2014), 12(supplément 3),

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See detailMuscle Mitochondrial Dysfunction in Horses Affected by Acute Laminitis
Serteyn, Didier ULg; de la Rebière de Pouyade, Geoffroy ULg; Sandersen, Charlotte ULg et al

in Bioenergetics (2014)

Laminitis is a common and debilitating disease affecting horses and ponies. It often leads to the demise of the animal. Energy deficiency is suspected to entrain the disruption of the hemidesmosomes ... [more ▼]

Laminitis is a common and debilitating disease affecting horses and ponies. It often leads to the demise of the animal. Energy deficiency is suspected to entrain the disruption of the hemidesmosomes leading to the failure of the dermal-epidermal interface. The aim of this study was to measure the muscle mitochondrial function by high resolution respirometry. Muscle micro-biopsies were obtained from 11 horses affected by acute metabolic laminitis, 6 horses affected by acute laminitis resulting from a systemic inflammation response syndrome and 28 healthy horses distributed in 2 control groups: 17 horses with a body condition score [BSC, ranging from 0 (emaciated) to 5 (obese)] of 2 to 3 and 11 horses with a BSC of 4 to 5. During the acute phase of laminitis, a significant reduction of the muscle mitochondrial respiration was observed. The muscle mitochondrial dysfunction occurred independently of the etiology (metabolic disorder or systemic inflammation) leading to laminitis. The reduction of the oxidative phosphorylation and of the maximal respiratory capacity (after uncoupling) may induce depletion of the cell’s ATP content. If the same mitochondrial alteration occurs in the foot lamina, mitochondria targeting should be considered for the future, not only to better understand the physiopathology of the disease but also to maintain and to support the mitochondrial function before reaching the « mitochondrial dysfunction threshold » that may lead to the failure of the dermal-epidermal interface. [less ▲]

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See detailEffect of Corn Substitution by Sorghum Grain with Low Tannin Content on Broilers Production: Animal Performance, Nutrient Digestibility and Carcass Characteristics
Mamadou Tandiang, Diaw; Thiam Diop, Mamadou; Dieng, Abdoulaye et al

in International Journal of Poultry Science (2014), 13(10), 568-574

The effect of substituting corn with sorghum grains with low tannin content (LTC) on broilers performances was investigated in a 6-week feeding trial. Seven hundred fifty 1-day old chicks and not sexed ... [more ▼]

The effect of substituting corn with sorghum grains with low tannin content (LTC) on broilers performances was investigated in a 6-week feeding trial. Seven hundred fifty 1-day old chicks and not sexed Coob 500 were used in this test. These animals were separated into five groups with three replicates of 50 birds for each one. A control diet with 50% of corn was used in the control group. Three other diets where corn was substituted by conventional sorghum in 1/3, 2/3 and 3/3 were given respectively to the G1/3, G2/3 and G3/3 groups. The GLTC groups received diets with total substitution of maize by sorghum with LTC. No significant difference was shown for the body weight between the control and the GLTC groups (respectively 1303 and 1418 g). But the use of conventional sorghum decreases significantly the broilers weight live (p>0.05) with the lower weight performances (1128 to 1225 g). Mortalities were similar for the different groups. It’s always results to climatic environment which was identical for the different group. No difference has been observed for the carcass dressing percentage (68 to 76%). For the nutrients digestibility, except the fat matter which was difference and higher (more than 92%), dry matter, ash and then metabolizable energy were similar (p>0.05) in the starting and growing diets. [less ▲]

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See detailLanduse change and future flood risk: the influence of micro-scale spatial patterns (FloodLand) - 2nd progress report
Dewals, Benjamin ULg; Bruwier, Martin ULg; El Saeid Mustafa, Ahmed Mohamed ULg et al

Report (2014)

The goal of the project FloodLand is to investigate the complex interactions between landuse change and future flood risk. Landuse change is assumed to be mainly driven by population growth and socio ... [more ▼]

The goal of the project FloodLand is to investigate the complex interactions between landuse change and future flood risk. Landuse change is assumed to be mainly driven by population growth and socio-economic factors. It affects future flood risk by altering catchment hydrology as well as vulnerability in the floodplains; but the feedback effect of (the perception of) changes in flood hazard on landuse evolution is also considered. The research is based on a chain of modelling tools, which represent parts of the natural and human systems, including: landuse change modelling, transportation modelling as an onset for the estimation of indirect flood damage, continuous hydrological modelling (forced by precipitation and temperature data disturbed according to climate change scenarios), as well as efficient hydraulic modelling of inundation flow in the floodplains. Besides reproducing a broad spectrum of processes, the modelling approach spans over multiple scales, from the regional or catchment level down to the floodplain and building levels. This distinctive feature is reflected both within the individual models and through their combination involving fine-scale detailed analyses (or data) embedded within coarser models at a broader level. [less ▲]

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See detailPCR-RFLP identification of the endangered Pyrenean desman, Galemys pyrenaicus (Soricomorpha, Talpidae), based on faecal DNA
Gillet, François ULg; Cabria Garrido, Maria Teresa; Némoz, Mélanie et al

in Mammalia (2014)

The Pyrenean desman is a vulnerable mammal species endemic to Pyrenees and the northern Iberian Peninsula. The presence of this elusive species can be most easily detected by sampling its faeces. However ... [more ▼]

The Pyrenean desman is a vulnerable mammal species endemic to Pyrenees and the northern Iberian Peninsula. The presence of this elusive species can be most easily detected by sampling its faeces. However, these faecal samples can be confused with those of other vertebrate species living in the same habitats. This study provides two easy and reliable methods for the identification of the Pyrenean desman faeces based on genetic analyses. The first one consists of a nested PCR and sequencing of a mitochondrial cytochrome b fragment, and the second one is an enzymatic digestion with endonucleases Alu I and Sau 3AI. The restriction patterns given by the two enzymes were found suitable for the successful discrimination of the Pyrenean desman from the other species based on species-specific sequence variations. [less ▲]

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See detailLa culture, grande absente ou objectif discret de l’agenda post-2015 ?
Vlassis, Antonios ULg

Article for general public (2014)

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See detailEGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP.
Paye, Alexandra ULg; Truong, Alice ULg; Yip, Cassandre ULg et al

in Cancer Research (2014), 74(23), 6758-70

MT4-MMP (MMP-17) is a GPI-anchored matrix metalloprotease expressed on the surface of cancer cells which promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver of ... [more ▼]

MT4-MMP (MMP-17) is a GPI-anchored matrix metalloprotease expressed on the surface of cancer cells which promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver of cancer cell proliferation through CDK4 activation and retinoblastoma protein (Rb) inactivation. We also determine a functional link between MT4-MMP and the growth factor receptor EGFR. Mechanistic experiments revealed direct association of MT4-MMP and its positive effects on EGFR phosphorylation in response to TGF- and EGF in cancer cells. Notably, the effects of MT4-MMP on proliferation and EGFR activation did not rely on metalloprotease activity. Clinically, MT4-MMP and EGFR expression were correlated in human triple negative breast cancer specimens. Altogether our results identify MT4-MMP as a positive modifier of EGFR outside-in signaling that acts to cooperatively drive cancer cell proliferation. [less ▲]

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See detailSquamocolumnar junction cells and HPV infection
Herfs, Michael ULg

Scientific conference (2014, October)

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See detailRole of the progesterone receptor in the development of sexual behavior in female mice
Desroziers, Elodie ULg; Brock, Olivier; Baum, M.J. et al

Conference (2014, October)

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See detailCalibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Cristol, Jean-Paul et al

in Journal of Nephrology (2014), 27(5), 467-75

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay ... [more ▼]

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay used, and calibration standardization is necessary. For SCr, isotope dilution mass spectrometry (IDMS) is the gold standard. Systematic differences are observed between Jaffe and enzymatic methods. Manufacturers subtract 0.30 mg/dl from Jaffe results to match enzymatic results (‘compensated Jaffe method’). The analytical performance of enzymatic methods is superior to that of Jaffe methods. In the original Modification of Diet in Renal Disease (MDRD) equation, SCr was measured by a Jaffe Beckman assay, which was later recalibrated. A limitation of this equation was an underestimation of GFR in the high range. The Chronic Kidney Disease Epidemiology (CKD-EPI) consortium proposed an equation using calibrated and IDMS traceable SCr. The gain in performance was due to improving the bias whereas the precision was comparable. The CKD-EPI equation performs better at high GFR levels (GFR[60 ml/ min/1.73 m2). Analytical limitations have led to the recommendation to give a grade ([60 ml/min/1.73 m2) rather than an absolute value with the MDRD equation. By using both enzymatic and calibrated methods, this cutoff-grade could be increased to 90 ml/min/1.73 m2 (with MDRD) and 120 ml/min/1.73 m2 (with CKD-EPI). The superiority of the CKD-EPI equation over MDRD is analytical, but the precision gain is limited. IDMS traceable enzymatic methods have been used in the development of the Lund– Malmo¨ (in CKD populations) and Berlin Initiative Study equations (in the elderly). The analytical errors for cystatin C are grossly comparable to issues found with SCr. Standardization is available since 2011. A reference method for cystatin C is still lacking. Equations based on standardized cystatin C or cystatin C and creatinine have been proposed. The better performance of these equations (especially the combined CKD-EPI equation) has been demonstrated. [less ▲]

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See detailSinuso-nasal adenocarcinoma in a roe deer (Capreolus capreolus)
Volpe, Rosario ULg; Cassart, Dominique ULg; Neukermans, Axel et al

Poster (2014, October)

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See detailFiscalité et Aménagement du Territoire
Bianchet, Bruno ULg; Xhignesse, Guillaume ULg; Farah, Jihad ULg et al

Report (2014)

Cette recherche consiste en une réflexion sur la fiscalité en tant qu'outil d'aménagement du territoire et en tant que moyen de recontrer les défis du développement territorial, dans le contexte wallon ... [more ▼]

Cette recherche consiste en une réflexion sur la fiscalité en tant qu'outil d'aménagement du territoire et en tant que moyen de recontrer les défis du développement territorial, dans le contexte wallon. Elle s'intègre dans le contexte des débats qui entourent la sixième réforme de l'Etat belge. Elle a pour objectif l'établissement d'un cadre utilisable pour l'évaluation de certains effets territoriaux suite à la mise en oeuvre ou à la modification de politiques fiscales. In fine, elle aboutira à des propositions d'adaptation ou de mise au point de nouvelles mesures en vue de rencontrer les défis territoriaux. Afin d'atteindre ces objectifs, elle se concentre également sur la mise en évidence des liens existants entre le système fiscal en place et certains défis territoriaux. Son objet est restreint au logement et à l'aménagement en lien avec le logement. [less ▲]

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See detailDevenir art-thérapeute
Vandeninden, Elise ULg

in SociologieS (2014)

In the field of mental health workers, a new profession is emerging: animators of art workshops in psychiatry, also called ‘art therapists’. Our paper reveals the results of a survey conducted in Belgium ... [more ▼]

In the field of mental health workers, a new profession is emerging: animators of art workshops in psychiatry, also called ‘art therapists’. Our paper reveals the results of a survey conducted in Belgium among these new professionals. In portraying this new group of ‘distributed’ workers, we will discuss the reasons for their difficult process of professionalization [less ▲]

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