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See detailBOLERO-3 : Everolimus plus Trastuzumab and Vinorelbine in asian patients with HER2-positive metastatic breast cancer
Toi, Masakazu; Masuda, Norikazu; ANDRE, Fabrice et al

Poster (2013, December)

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See detailCURRENT CROWDING EFFECTS IN NANOSTRUCTURED SUPERCONDUCTORS
Silhanek, Alejandro ULg

Conference (2013, December)

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See detailExpanding the CHARA/FLUOR hot disk survey
Mennesson, B.; Scott, N.; Ten Brummelaar, T. et al

in Journal of Astronomical Instrumentation (2013), 2(2), 1340010

Little is presently known about the hot (>300 K) dust component of debris disks surrounding main sequence stars, similar to the zodiacal dust cloud found in the inner solar system.While extensive surveys ... [more ▼]

Little is presently known about the hot (>300 K) dust component of debris disks surrounding main sequence stars, similar to the zodiacal dust cloud found in the inner solar system.While extensive surveys have been carried out from space, the majority of detections have surprisingly come from the ground, where near infrared interferometric observations have recently revealed small (∼1%) resolved excesses around a dozen nearby main sequence stars. Most of these results have come from the CHARA array “FLUOR” instrument (Mt. Wilson, CA), which has demonstrated the best sensitivity worldwide so far for this type of studies, and has carried out an initial survey of ∼40 stars. In order to further understand the origin of this “hot dust phenomenon”, we will extend this initial survey to a larger number of stars and lower excess detection limits, i.e. higher visibility accuracy providing higher contrast measurements. To this end, two major instrumental developments are underway at CHARA. The first one aims at improving FLUOR’s sensitivity to a median K-band magnitude limit of 5 (making 200 targets available). The second development is based on a method that we recently developed for accurate (better than 0.1%) null depth measurements of stars, and that can be extended to regular interferometric visibility measurements. [less ▲]

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See detailQuadratization of symmetric pseudo-Boolean functions
Anthony, Martin; Boros, Endre; Crama, Yves ULg et al

E-print/Working paper (2013)

A pseudo-Boolean function is a real-valued function $f(x)=f(x_1,x_2,\ldots,x_n)$ of $n$ binary variables; that is, a mapping from $\{0,1\}^n$ to ${\bbr}$. For a pseudo-Boolean function $f(x)$ on $\{0,1 ... [more ▼]

A pseudo-Boolean function is a real-valued function $f(x)=f(x_1,x_2,\ldots,x_n)$ of $n$ binary variables; that is, a mapping from $\{0,1\}^n$ to ${\bbr}$. For a pseudo-Boolean function $f(x)$ on $\{0,1\}^n$, we say that $g(x,y)$ is a quadratization of $f$ if $g(x,y)$ is a quadratic polynomial depending on $x$ and on $m$ auxiliary binary variables $y_1,y_2,\ldots,y_m$ such that $f(x)= \min \{ g(x,y) : y \in \{0,1\}^m \} $ for all $x \in \{0,1\}^n$. By means of quadratizations, minimization of $f$ is reduced to minimization (over its extended set of variables) of the quadratic function $g(x,y)$. This is of some practical interest because minimization of quadratic functions has been thoroughly studied for the last few decades, and much progress has been made in solving such problems exactly or heuristically. A related paper initiated a systematic study of the minimum number of auxiliary $y$-variables required in a quadratization of an arbitrary function $f$ (a natural question, since the complexity of minimizing the quadratic function $g(x,y)$ depends, among other factors, on the number of binary variables). In this paper, we determine more precisely the number of auxiliary variables required by quadratizations of \emph{symmetric} pseudo-Boolean functions $f(x)$, those functions whose value depends only on the Hamming weight of the input $x$ (the number of variables equal to 1). [less ▲]

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See detailEvolution of the theoretical power spectrum of solar-like oscillations along the ascending phase on the red giant branch.
Grosjean, Mathieu ULg; Dupret, Marc-Antoine ULg; Belkacem, Kevin et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. An important question comes from the observation of mixed ... [more ▼]

CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. An important question comes from the observation of mixed modes : When during the star’s ascension on the RGB are mixed-modes more likely to be detectable ? We follow the evolution of a star on the RGB and investigate the effect of its ascension on theoretical power spectrum. Equilibrium models (computed with the code ATON) represent four different stages of a star on the RGB. The mass of the star (1.5M") is in the typical mass range of stars observed by CoRoT and Kepler. We used a non-radial non-adiabatic code to compute the theoretical solar-like oscillations of these models. An important output of these calculations is the theoretical lifetimes of the modes. Then we computed the oscillation amplitudes through a stochastic excitation model. These computations allow us to draw theoretical power spectrum and discuss the possibility to observe mixed-modes at different evolutionary stages on the RGB. We found that structure modifications in a star ascending the RGB have an important impact on theoretical power spectrum of solar-like oscillations. Efficiencies of trapping and lifetimes of mixed modes are indeed strongly affected by this evolution. [less ▲]

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See detailDes prix littéraires. Approches marginales
Dozo, Björn-Olav ULg

Article for general public (2013)

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See detailTechnologie de production de masse d’insectes - INSECTECH
Richard, Gaetan ULg; Hance, Thierry; Fauconnier, Marie-Laure ULg et al

Report (2013)

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See detailChimpanzee (Pan troglodytes schweinfurthii)Population Density and Abundance in Kibira National Park,Burundi
Hakizimana, Dismas ULg; Huynen, Marie-Claude ULg

in Pan Africa News (2013), 20(2), 16-19

Successful conservation and management strategy of wild animals usually starts by assessing their population size. This is of particular relevance in areas submitted to long periods of human conflicts ... [more ▼]

Successful conservation and management strategy of wild animals usually starts by assessing their population size. This is of particular relevance in areas submitted to long periods of human conflicts which is the case of Burundi. A census of chimpanzee populations was made throughout Kibira National Park between September 2011 and February 2013 to provide reliable information on density estimates of chimpanzees inhabiting the forest. The method was based on marked nest counts from line transects which allowed the calculation of population densities of all weaned individuals. We recorded a total of 471 chimpanzee nests in four sectors of the park (Mabayi 290 nests, Rwegura 68 Teza 65 and Musigati 48). We derived an estimate of the total population of 203 (122-339) weaned chimpanzees in the whole park. We discuss that result in perspective of necessiry of future research on chimpanzees in Burundi. First, implementation of a monitoring program of chimpanzee is necessary to constitute a database, as well as collecting data of tree phenology on which chimpanzee depend. Second, an effective transboundary strategic plan to conserve Kibira-Nyungwe as one landscape is necessary to maintain viable population of chimpanzees. [less ▲]

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See detailMorphological and Molecular Characterization of Lymnaeid Snails and Their Potential Role in Transmission of Fasciola spp. in Vietnam
Bui Thi, Dung ULg; Pham Ngoc, Doanh; Dang Tat, The et al

in Korean Journal of Parasitology (2013), 51(6), 657-662

Freshwater snails of the family Lymnaeidae play an important role in the transmission of fascioliasis worldwide. In Vietnam, 2 common lymnaeid species, Lymnaea swinhoei and Lymnaea viridis, can be ... [more ▼]

Freshwater snails of the family Lymnaeidae play an important role in the transmission of fascioliasis worldwide. In Vietnam, 2 common lymnaeid species, Lymnaea swinhoei and Lymnaea viridis, can be recognized on the basis of morphology, and a third species, Lymnaea sp., is known to exist. Recent studies have raised controversy about their role in transmission of Fasciola spp. because of confusion in identification of the snail hosts. The aim of this study is, therefore, to clarify the identities of lymnaeid snails in Vietnam by a combination of morphological and molecular approaches. The molecular analyses using the second internal transcribed spacer (ITS2) of the nuclear ribosomal DNA clearly showed that lymnaeids in Vietnam include 3 species, Austropeplea viridis (morphologically identified as L. viridis), Radix auricularia (morphologically identified as L. swinhoei) and Radix rubiginosa (morphologically identified as Lymnaea sp.). R. rubiginosa is a new record for Vietnam. Among them, only A. viridis was found to be infected with Fasciola spp. These results provide a new insight into lymnaeid snails in Vietnam. Identification of lymnaeid snails in Vietnam and their role in the liver fluke transmission should be further investigated. [less ▲]

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See detailPeptidomic comparison and characterization of the major components of the venom of the giant ant Dinoponera quadriceps collected in four different areas of Brazil.
Cologna, Camila Takeno; Cardoso, Jaqueline Dos Santos; Jourdan, Emmanuel et al

in Journal of Proteomics (2013), 94

Despite the noxious effects inflicted by Dinoponera ant's envenomation, the information about the biological properties and composition of their venom is still very limited. Ants from the genus Dinoponera ... [more ▼]

Despite the noxious effects inflicted by Dinoponera ant's envenomation, the information about the biological properties and composition of their venom is still very limited. Ants from the genus Dinoponera are believed to be the world's largest living ants with a body length of 3cm. Their occurrence is restricted to tropical areas of South America. In this work, we study the venom of the giant Dinoponera quadriceps ant collected in 4 different regions of Brazil. By using a combination of complementary mass spectrometric approaches, we aim at: (i) characterizing the venom composition of these ants; (ii) establishing a comparative analysis of the venom from four geographically different regions in Brazil. This approach demonstrates that ant venom is a copious source of new compounds. Several peptides were identified and selected for "de novo sequencing". Since most of the new peptides showed similarities with antimicrobial peptides (AMPs), antimicrobial assays were performed with the purpose of evaluating their activity. In regard to the comparative study of the four regions, we observed not only major differences in the venom compositions, but also that the venoms collected in closest areas are more similar than the ones collected in distant regions. These observations seem to highlight an adaption of the ant venoms to the local environment. Concerning the biological assays, the peptides called Dq-3162 and Da-3177 showed a wide-ranging antimicrobial activity. The characterization of new AMPs with a broad spectrum of activity and different scaffolds may aid scientists to design new therapeutic agents and understand the mechanisms of those peptides to interact with microbial membranes. The results obtained betoken the biotechnological potential of ant's venom. BIOLOGICAL SIGNIFICANCE: For the first time this manuscript describes an extensive proteomics characterization of the D. quadriceps venom. In addition this study reports the variation in venom composition of primitive ants from 4 geographically different areas of Brazil. The results reveal the presence of ~335 compounds for each venom/area and inter-colony variations were observed. 16 new peptides were characterized and 2 of them were synthesized and biologically assayed. These findings highlight the considerable and still unexplored diversity of ant's venom which could be used as valuable research tools in different areas of knowledge. [less ▲]

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See detailHistology of the vaginal wall in women with pelvic organ prolapse: a literature review.
DE LANDSHEERE, Laurent ULg; Munaut, Carine ULg; Richelle, Betty ULg et al

in International Urogynecology Journal (2013), 24(12), 2011-20

INTRODUCTION AND HYPOTHESIS: The pathophysiology of pelvic organ prolapse (POP) is incompletely understood. The purpose of this study is to describe the current knowledge about histology of the vaginal ... [more ▼]

INTRODUCTION AND HYPOTHESIS: The pathophysiology of pelvic organ prolapse (POP) is incompletely understood. The purpose of this study is to describe the current knowledge about histology of the vaginal wall and its possible involvement in the pathogenesis of pelvic organ prolapse. METHODS: Eligible studies were selected through a MEDLINE search covering January 1986 to December 2012. The research was limited to English-language publications. RESULTS: Investigations of changes in the vaginal tissue that occur in women with genital prolapse are currently still limited and produced contrary results. The heterogeneity of the patients and the control groups in terms of age, parity and hormonal status, of the localization of biopsies and the histological methods as well as the lack of validation of the quantification procedures do not allow clear and definitive conclusions to be drawn. CONCLUSIONS: This review shows that current knowledge of the histological changes observed in women with POP are inconclusive and relatively limited. More studies are needed in this specific field to better understand the mechanisms that lead to POP. [less ▲]

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See detailHigh-resolution modelling of the Antarctic surface mass balance, application for the twentieth, twenty first and twenty second centuries
Agosta, Cécile ULg; Favier, Vincent; Krinner, Gerhard et al

in Climate Dynamics (2013), 41(11-12), 3247-3260

About 75% of the Antarctic surface mass gain occurs over areas below 2000 m asl, which cover 40% of the grounded ice-sheet. As the topography is complex in many of these regions, SMB modelling is highly ... [more ▼]

About 75% of the Antarctic surface mass gain occurs over areas below 2000 m asl, which cover 40% of the grounded ice-sheet. As the topography is complex in many of these regions, SMB modelling is highly dependent on resolution, and studying the impact of Antarctica on the future rise in sea level requires physical approaches. We have developed a low time consuming, physical downscaling model for high-resolution (15 km) long-term surface mass balance (SMB) projections. Here, we present results of this model, called SMHiL (surface mass balance high-resolution downscaling), which was forced with the LMDZ4 atmospheric general circulation model to assess SMB variation in the 21st and the 22nd centuries under two different scenarios. The higher resolution of SMHiL better reproduces the geographical patterns of SMB and increase significantly the averaged SMB over the grounded ice-sheet for the end of the 20th century. A comparison with more than 3200 quality-controlled field data shows that LMDZ4 and SMHiL compare the observed values equally well. Nevertheless, field data below 2000 m asl are too scarce to efficiency show the interest of SMHiL and measuring the SMB in these undocumented areas should be then a future scientific priority. Our results suggest that running LMDZ4 at a finer resolution (15km) may give a future increase in SMB in Antarctica about 30% higher than by using its standard resolution (60 km) due to higher increase in precipitation in the coastal areas at 15 km. However, a part (~ 15%) of these discrepancies could be an artefact from SMHiL since it neglects the foehn effect and then likely overestimates the precipitation increase. Future changes in the Antarctic SMB at low elevations will result from the conflict between higher snow accumulation and runoff. For this reason, developing downscaling models is crucial to represent processes in sufficient detail and correctly model the SMB in the coastal areas. [less ▲]

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See detailRivaling Evidence-Bases and Politics in Regulatory Science
Hendrickx, Kim ULg

in Food Science and Law (2013), 4

In line with contemporary political and sociological research on science and regulation, this article problematizes the notion of ‘scientific evidence’ as something independent from and prior to political ... [more ▼]

In line with contemporary political and sociological research on science and regulation, this article problematizes the notion of ‘scientific evidence’ as something independent from and prior to political values. The production of scientific or technical criteria supporting regulatory politics is referred to as ‘regulatory science’ in the fields of policy studies and the sociology of science and technology. Evidence-bases are an example of regulatory science and they illustrate the latter’s intimate relation with political values. I will briefly outline how evidence-bases are not a neutral basis for politics, but that they are constructed through politics and interested groups. Taking the European health claims debate as an example, I show that there exists no unitary notion of evidence, but a confrontation of two scientific frameworks, supported by different expert networks, and proposing different conceptions of what scientific 'evidence' is. In regulatory matters, scientific evidence alone cannot settle disputes once and for all because the evidence is precisely what's at stake. [less ▲]

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See detailModel Predictive Control of Voltages in Active Distribution Networks
Valverde Mora, Gustavo ULg; Van Cutsem, Thierry ULg

in IEEE Transactions on Smart Grid (2013), 4(4), 2152-2161

This paper presents a centralized control scheme to regulate distribution network voltages in the presence of high penetration of distributed generation. The approach is inspired of Model Predictive ... [more ▼]

This paper presents a centralized control scheme to regulate distribution network voltages in the presence of high penetration of distributed generation. The approach is inspired of Model Predictive Control in order to compensate for modeling inaccuracies and measurement noise. The control actions, calculated from a multi-step optimization, are updated and corrected by real-time measurements. The proposed controller uses a linear model to predict the behavior of the system and the optimization is solved using quadratic programming. The proposed corrective control has been tested in a 11-kV distribution network including 75 nodes and hosting 22 distributed generating units. [less ▲]

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