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See detailreview of Frédéric Duval, Les mots de l'édition de textes
Morato, Nicola ULg

in French Studies (2016), 70(2),

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See detailConstraints on the structure of 16 Cygni A and 16 Cygni B using inversion techniques
Buldgen, Gaël ULg; Reese, Daniel; Dupret, Marc-Antoine ULg

in Astronomy and Astrophysics (2016)

Abstract Constraining mixing processes and chemical composition is a central problem in stellar physics as their impact on stellar age determinations leads to biases in our studies of stellar evolution ... [more ▼]

Abstract Constraining mixing processes and chemical composition is a central problem in stellar physics as their impact on stellar age determinations leads to biases in our studies of stellar evolution, galactic history and exoplanetary systems. In two previous papers, we showed how seismic inversion techniques could offer strong constraints on such processes by pointing out weaknesses in theoretical models. We now apply our technique to the solar analogues 16CygA and 16CygB, being amongst the best targets in the Kepler field to test the diagnostic potential of seismic inversions. The combination of various seismic indicators helps to provide more constrained and accurate fundamendal parameters for these stars. We use the latest seismic, spectroscopic and interferometric observational constraints in the litterature for this system to determine reference models independently for both stars. We carry out seismic inversions of the acoustic radius, the mean density and a core conditions indicator. We note that a degeneracy exists for the reference models. Namely, changing the diffusion coefficient or the chemical composition within the observational values leads to 5% changes in mass, 3% changes in radius and up to 8% changes in age. We use acoustic radius and mean density inversions to improve our reference models then carry out inversions for a core conditions indicator. Thanks to its sensitivity to microscopic diffusion and chemical composition mismatches, we are able to reduce the mass dispersion to 2%, namely [0.96, 1.0] M_sun, the radius dispersion to 1%, namely [1.188, 1.200] R_sun and the age dispersion to 3%, namely [7.0, 7.4] Gy, for 16CygA. For 16CygB, we can check the consistency of the models but not reduce independently the age dispersion. Nonetheless, assuming consistency with the age of 16CygA helps to further constrain its mass and radius. [less ▲]

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See detailA Simple Tiered Methodology for the Determination of Ambient Air Quality Guidelines
PIRARD, Catherine ULg; Brouhon, Jean-Marc; Fourmeaux, Annick et al

in Clean : Soil, Air, Water (2016), 44

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See detailPathologie du muscle - Complications - Traitements
Kaux, Jean-François ULg

Learning material (2016)

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See detailẾtude de l’émergence des organisations pastorales et de leur rôle dans les processus de gestion partagée de la vallée de la Tarka dans les départements de Bermo et Dakoro (Centre sud du Niger)
Ibrahim, Habibou ULg

Doctoral thesis (2016)

Cette thèse vise à analyser les organisations pastorales et leurs rôles dans la gestion des conflits fonciers. En Afrique subsaharienne et particulièrement au Niger, le foncier est au centre des enjeux de ... [more ▼]

Cette thèse vise à analyser les organisations pastorales et leurs rôles dans la gestion des conflits fonciers. En Afrique subsaharienne et particulièrement au Niger, le foncier est au centre des enjeux de l’agro-pastoralisme. La sécurisation des droits d’accès aux ressources et des systèmes de tenure foncière sont essentiels pour la gestion et la résolution des conflits fonciers (Herrea et al., 2007). La région de Maradi constitue la zone de contact entre le Nord pastoral et le Sud agricole. Dans cette partie centrale où la pression foncière, aggravée par la croissance démographique, se pose avec acuité, le spectre des conflits fonciers est malheureusement devenu un phénomène chronique, une donnée permanente (GADO., 2000). La pluralité des normes et plusieurs sources de droit contribuent à complexifier le règlement des litiges fonciers entre acteurs dans les départements de Dakoro et Guidan Roumdji (Moutari., 2001). Or la dynamique globale des systèmes d’élevage est déterminée par la complémentarité des espaces agro-pastoraux. Cette complémentarité est remise en cause par ces pressions foncières et suscite des changements organisationnels dans les communautés du centre Sud du Niger (Yamba., 2004 ; 2000). C’est le rôle des associations pastorales à Dakoro et Bermo qui est l’objet de cette recherche. En effet les organisations paysannes en Afrique Subsaharienne et au Niger en particulier jouent un rôle important dans la définition des politiques agricoles et deviennent des conditions indiscutables de la réussite des actions à promouvoir à l’échelle locale (Courade et Deveze., 2006 ; Mercoiret, 2006 ; Mercoiret et al. 2004). La méthodologie de travail relève de l’approche ethnographique. Les outils et instruments d’enquête sont les questionnaires et les entretiens ouverts avec les acteurs locaux sur les dynamiques territoriales, les modes d’action des associations pastorales et les conflits fonciers. Les résultats viennent aussi des travaux et des documents des projets, des ONG et des rapports des services techniques de l’Etat. Pour un souci de fiabilité des données, nous avons tenu à réaliser des séances de restitution des données et de triangulations pour confronter les informations de diverses sources. Au total 104 personnes sont enquêtées dont 30 % auprès des associations. Ces investigations ont concerné aussi les secrétaires des commissions foncières, les préfets, les agents des projets et des ONG et le président du tribunal de Dakoro ainsi que les leaders pastoraux, les transhumants, les agriculteurs et associations pastorales. [less ▲]

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See detailCompte rendu de Christophe CHANDEZON, Julien DU BOUCHET (éds.), Artémidore de Daldis et l’interprétation des rêves. Quatorze études
Berg, Tatiana ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2016), 85

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See detailHDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies
Peixoto, Paul; Blomme, Arnaud; Costanza, Brunella ULg et al

in Oncogene (2016)

To date, the mutational status of EGFR and PTEN has been shown as relevant for favoring pro- or anti-tumor functions of STAT3 in human glioblastoma multiforme (GBM). We have screened genomic data from 154 ... [more ▼]

To date, the mutational status of EGFR and PTEN has been shown as relevant for favoring pro- or anti-tumor functions of STAT3 in human glioblastoma multiforme (GBM). We have screened genomic data from 154 patients and have identified a strong positive correlation between STAT3 and HDAC7 expression. In the current work we show the existence of a subpopulation of patients overexpressing HDAC7 and STAT3 that has particularly poor clinical outcome. Surprisingly, the somatic mutation rate of both STAT3 and HDAC7 was insignificant in GBM comparing with EGFR, PTEN or TP53. Depletion of HDAC7 in a range of GBM cells induced the expression of tyrosine kinase JAK1 and the tumor suppressor AKAP12. Both proteins synergistically sustained the activity of STAT3 by inducing its phosphorylation (JAK1) and protein expression (AKAP12). In absence of HDAC7, activated STAT3 was responsible for significant imbalance of secreted pro-/anti-angiogenic factors. This inhibited the migration and sprouting of endothelial cells in paracrine fashion in vitro as well as angiogenesis in vivo. In a murine model of GBM, induced HDAC7-silencing decreased the tumor burden by threefold. The current data show for the first time that silencing HDAC7 can reset the tumor suppressor activity of STAT3, independently of the EGFR/PTEN/TP53 background of the GBM. This effect could be exploited to overcome tumor heterogeneity and provide a new rationale behind the development of specific HDAC7 inhibitors for clinical use. [less ▲]

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See detailSafety in Long Term Radioactive Waste Management: Insight and Oversight
Schröder, Jantine; Rossignol, Nicolas ULg; Van Oudheusden, Michiel ULg

in Safety Science (2016), 85

High-level, long-lived radioactive waste remains hazardous for periods that go well beyond our human conception of time (many thousands of years). Because active safety measures are considered unreliable ... [more ▼]

High-level, long-lived radioactive waste remains hazardous for periods that go well beyond our human conception of time (many thousands of years). Because active safety measures are considered unreliable, unjustifiable and simply impossible over such long time spans, experts worldwide recommend geological disposal as the preferred strategy for long-term radioactive waste management, to a large extent due to its promise of delivering ‘passive safety’. Passive safety refers to the repository being safe ‘by itself’, i.e. unmediated by human actors and actions. Safety is thus approached technically and delineated as an intrinsic property of the disposal system. As such, the notion of 'passive safety' entails a system simplification that allows for approaching safety in a more calculable and predictable manner than would be the case for 'active safety'. In this article, we describe and analyze the ambiguity of this seemingly straightforward approach to safety. Drawing on constructivist insights from safety science and science and technology studies, we propose a more integrated sociotechnical vision that transcends the active versus passive safety division. The notion of 'oversight', as it is currently starting to surface in international radioactive waste management discourses, will be used as a sensitizing concept, offering potential to elaborate such an integrated vision. [less ▲]

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See detailGait speed or gait variability, which one to use as a marker of risk to develop Alzheimer's disease ? A pilot study
GILLAIN, Sophie ULg; DRAME, M; LEKEU, Françoise ULg et al

in Aging Clinical and Experimental Research (2016), 28(2), 249-255

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See detailLike a bridge over troubled water – opening pathways for integrating social sciences and humanities into nuclear research
Turcanu, Catrinel; Schröder, Jantine; Meskens, Gaston et al

in Journal of Environmental Radioactivity (2016), 153

Research on nuclear technologies has been largely driven by a detachment of the 'technical content' from the 'social context'. However, social studies of science and technology - also for the nuclear ... [more ▼]

Research on nuclear technologies has been largely driven by a detachment of the 'technical content' from the 'social context'. However, social studies of science and technology - also for the nuclear domain – emphasize that 'the social' and 'the technical' dimensions of technology development are inter-related and co-produced. In an effort to create links between nuclear research and innovation and society in mutually beneficial ways, the Belgian Nuclear Research Centre started fifteen years ago a ‘Programme of Integration of Social Aspects into nuclear research’ (PISA). In line with broader science-policy agendas (responsible research and innovation and technology assessment), this paper argues that the importance of such programmes is threefold. First, their multi-disciplinary basis and participatory character contribute to a better understanding of the interactions between science, technology and society, in general, and the complexity of nuclear technology assessment in particular. Second, their functioning as (self )critical policy supportive research with outreach to society is an essential prerequisite for policies aiming at generating societal trust in the context of controversial issues related to nuclear technologies and exposure to ionising radiation. Third, such programmes create an enriching dynamic in the organisation itself, stimulating collective learning and transdisciplinarity. The paper illustrates with concrete examples these claims and concludes by discussing some key challenges that researchers face while engaging in work of this kind. [less ▲]

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See detailFacteurs pronostiques du cancer pulmonaire non à petites cellules
GESTER, Fanny; PAULUS, Astrid ULg; SIBILLE, Anne ULg et al

in Revue Médicale de Liège (2016), 71(1), 34-39

Summary : Non small cell lung cancer is the most frequent type of lung cancer and its prognosis is still very poor. Relapse is frequent and can be observed even in early stages of the disease, in spite of ... [more ▼]

Summary : Non small cell lung cancer is the most frequent type of lung cancer and its prognosis is still very poor. Relapse is frequent and can be observed even in early stages of the disease, in spite of a surgical management with curative intent. This paper gives an overview of the main prognostic factors, the two most important of which remain the staging and tumor histology. These also determine the therapeutic strategy. Other factors of poor prognosis might also be useful for clinicians, particularly in their decision to refer patients for adjuvant therapies. Keywords : Non-small cell lung cancer – Prognostic factors – Pulmonary oncology – Surgery [less ▲]

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See detailYellow nail syndrome after allogeneic haematopoietic stem cell transplantation in two patients with multiple myeloma
Grégoire, Céline ULg; GUIOT, Julien ULg; Vertenoeil, Gaëlle ULg et al

in Acta Clinica Belgica (2016)

Objective and Importance: Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology characterized by the triad of yellow nails, lymphoedema and respiratory manifestations. About 200 cases have ... [more ▼]

Objective and Importance: Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology characterized by the triad of yellow nails, lymphoedema and respiratory manifestations. About 200 cases have been reported, but a lot of patients probably elude proper diagnosis because of both variability of symptoms and ignorance of this syndrome by many physicians. The pathogenesis remains unclear, and could involve functional lymphatic abnormalities, microvasculopathy or lymphocyte deficiency, but none of these hypotheses seems fully satisfactory. Clinical Presentation: We report for the first time two cases of YNS associated with multiple myeloma relapsing after non-myeloablative haematopoietic cell transplantation (HCT). In these two cases, onset or worsening of YNS symptoms followed graft-versus-host disease (GvHD) manifestations. Intervention: Corticosteroids given to treat GvHD also improved YNS manifestations. Conclusion: YNS after HCT might be a microvascular manifestation of endothelial GvHD and corticosteroids might be an effective treatment. [less ▲]

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See detailHet signalement van paardachtigen
Gérardy, Cécile; Cabaraux, Jean-François ULg

Book published by BCP-CBC (2016)

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See detailLe signalement des équidés
Gérardy, Cécile; Cabaraux, Jean-François ULg

Book published by BCP-CBC (2016)

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See detailDifferential Expression of Genes and DNA Methylation associated with Prenatal Protein Undernutrition by Albumen Removal in an avian model
Willems, E.; Guerrero-Bosagna, C.; Decuypere, E. et al

in Scientific Reports (2016), 6

Previously, long-term effects on body weight and reproductive performance have been demonstrated in the chicken model of prenatal protein undernutrition by albumen removal. Introduction of such persistent ... [more ▼]

Previously, long-term effects on body weight and reproductive performance have been demonstrated in the chicken model of prenatal protein undernutrition by albumen removal. Introduction of such persistent alterations in phenotype suggests stable changes in gene expression. Therefore, a genomewide screening of the hepatic transcriptome by RNA-Seq was performed in adult hens. The albumendeprived hens were created by partial removal of the albumen from eggs and replacement with saline early during embryonic development. Results were compared to sham-manipulated hens and non-manipulated hens. Grouping of the differentially expressed (DE) genes according to biological functions revealed the involvement of processes such as 'embryonic and organismal development' and 'reproductive system development and function'. Molecular pathways that were altered were 'amino acid metabolism', 'carbohydrate metabolism' and 'protein synthesis'. Three key central genes interacting with many DE genes were identified: UBC, NR3C1, and ELAVL1. The DNA methylation of 9 DE genes and 3 key central genes was examined by MeDIP-qPCR. The DNA methylation of a fragment (UBC-3) of the UBC gene was increased in the albumen-deprived hens compared to the nonmanipulated hens. In conclusion, these results demonstrated that prenatal protein undernutrition by albumen removal leads to long-term alterations of the hepatic transcriptome in the chicken. [less ▲]

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