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See detailJustice révolutionnaire v. justice d’Etat. Les années de plomb en Italie, entre représentations cinématographiques et représentations juridiques
Thirion, Nicolas ULg; Pasteger, David ULg

Conference (2015, March 13)

La présente contribution a une double ambition : d’une part, étudier, illustrations cinématographiques à l’appui, l’acte de juger et ses prodromes (enquêtes, procédures, interrogatoires, etc.), dans un ... [more ▼]

La présente contribution a une double ambition : d’une part, étudier, illustrations cinématographiques à l’appui, l’acte de juger et ses prodromes (enquêtes, procédures, interrogatoires, etc.), dans un contexte géographique et historique bien déterminé – en l’espèce, l’Italie des années de plomb – ; d’autre part, examiner les situations ainsi rencontrées à la lumière d’une théorie du droit – en l’occurrence, la théorie de la pluralité des ordres juridiques de Santi Romano – particulièrement éclairante pour comprendre les ressorts de la lutte à laquelle se livrèrent, dans ce cadre, organisations subversives, voire terroristes, et forces étatiques, aussi bien d’un point de vue historique que dans les représentations plus ou moins fidèles qui en ont été faites dans le corpus cinématographique retenu pour les besoins de la démonstration. [less ▲]

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See detailL’administration Obama, est-elle dépourvue d’une stratégie internationale ?
Santander, Sébastian ULg

Conference given outside the academic context (2015)

Detailed reference viewed: 9 (3 ULg)
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See detailDu travestissement à la traversée. À propos d’un bas-relief romain
Veymiers, Richard ULg

Conference (2015, March 13)

Detailed reference viewed: 11 (1 ULg)
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See detailThe living of the green microalga Chlamydomonas reinhardtii in day/night cycles
Willamme, Rémi ULg; Alsafra, Zouheir; Alsafra, Rameshkumar et al

Poster (2015, March 13)

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See detailLe et la cache. De quelques documentaires qui rendent visibles sans montrer.
Hamers, Jérémy ULg

Conference (2015, March 13)

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See detailArtificial Intelligence in Video Games: Towards a Unified Framework
Safadi, Firas ULg; Fonteneau, Raphaël ULg; Ernst, Damien ULg

in International Journal of Computer Games Technology (2015), 2015

With modern video games frequently featuring sophisticated and realistic environments, the need for smart and comprehensive agents that understand the various aspects of complex environments is pressing ... [more ▼]

With modern video games frequently featuring sophisticated and realistic environments, the need for smart and comprehensive agents that understand the various aspects of complex environments is pressing. Since video game AI is often specifically designed for each game, video game AI tools currently focus on allowing video game developers to quickly and efficiently create specific AI. One issue with this approach is that it does not efficiently exploit the numerous similarities that exist between video games not only of the same genre, but of different genres too, resulting in a difficulty to handle the many aspects of a complex environment independently for each video game. Inspired by the human ability to detect analogies between games and apply similar behavior on a conceptual level, this paper suggests an approach based on the use of a unified conceptual framework to enable the development of conceptual AI which relies on conceptual views and actions to define basic yet reasonable and robust behavior. The approach is illustrated using two video games, Raven and StarCraft: Brood War. [less ▲]

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See detailConclusions non conclusives
Servais, Amandine ULg

Scientific conference (2015, March 13)

« Conclusions non conclusives », communication prononcée le 13 mars 2015, au terme de la journée d’études « Être touché. Autour de Jean-Christophe Bailly ». Cette brève intervention proposait un retour ... [more ▼]

« Conclusions non conclusives », communication prononcée le 13 mars 2015, au terme de la journée d’études « Être touché. Autour de Jean-Christophe Bailly ». Cette brève intervention proposait un retour réflexif – via un détour par la pratique de l’historienne Arlette Farge – sur les procédés méthodologiques originaux que le groupe de contact défend. Comprendre le monde, l’observer, le parcourir avec le sensible c’est appréhender le temps comme vécu. Donc, si étudier le sensible implique de mobiliser les moyens du sensible, cela ne suffit pas : c’est bien la structure-même de notre pensée, arrimée ou articulée à la question du temps, qui est troublée. [less ▲]

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See detailFrom photons to biomass in green microalgae: fluorimetric and oxymetric studies on the regulation of photosynthetic electron transport
de Marchin, Thomas ULg

Doctoral thesis (2015)

Analyzing the photosynthetic performances of microalgae has become an important topic in view of the ecological importance of these microorganisms and of the growing field of their biotechnological ... [more ▼]

Analyzing the photosynthetic performances of microalgae has become an important topic in view of the ecological importance of these microorganisms and of the growing field of their biotechnological applications. In this thesis, we developed methods which allow effective use of fluorescence and oxygen experimental signals for a more complete analysis of the functioning of the photosynthetic apparatus of green microalgae under different conditions. We applied these methods to analyze the adaptations of the photosynthetic apparatus under selected conditions, especially regarding CO2 supply. In the first part of this work, we applied a fluorescence-based method for determining the PSII antenna size based on the kinetics of the fast chlorophyll a fluorescence transient in presence of DCMU (or DCMU Fluorescence Rise). We then performed a detailed analysis of the different phases of this transient which are associated with different types of PSII formerly described as PSIIalpha and PSIIbeta (PSII heterogeneity). Our results on PSII heterogeneity during a transition from state 2 to state 1 in Chlamydomonas reinhardtii showed for the first time in vivo that this transition correlates with a conversion of PSIIbeta to PSIIalpha. We also discuss the possible relationships between PSIIalpha and PSIIbeta and the PSII mega-, super- and core- complexes described by biochemical studies. In photoautotophic atmospheric conditions, microalgae often have to deal with limited CO2 availability. The unicellular green algae Chlamydomonas reinhardtii can adapt to low CO2 concentration with the inorganic carbon concentration mechanism (CCM). This has been extensively studied in the past. However, other functional adaptations of the photosynthetic apparatus to CO2 limitation have been much less studied. In the second part of this work, we used combined fluorescence-based electron transport and oxygen measurements to evaluate the responses to low and high CO2 in Chlamydomonas reinhardtii grown in photobioreactors at different light intensities. We developed a method to rationalize the relationship between the apparent quantum yields of oxygen evolution and of electron transport at PSII while taking into account the variations in the proportion of energy absorbed by PSII. We used this relationship as a tool to evidence a significant O2-dependent alternative electron transport in low CO2 acclimated cells. We showed that this alternative electron transport can represent up to 60% of the total electron transport in low CO2 cells even upon removal of the CO2 limitation by bicarbonate addition. In contrast, no significant alternative electron transport was detected in high CO2 cells. We suggest that the alternative electron transport to O2 observed in low CO2 cells represents an adaptation that could help to meet the higher ATP demand for the concentration of CO2 by the CCM. In contrast, in high CO2 conditions, the absence of the CCM would reduce the need for ATP and thus the need for electron transport to O2. Using mutants and inhibitors, we studied the involvement of known O2-dependent electron sinks such as the mitochondrial cytochrome and alternative oxidase pathways and also of chlororespiration in this light-dependent O2 uptake and we found no evidence for the involvement of any of these processes. The alternative electron transport was even higher in a mitochondrial mutant devoid of complexes I and III and we suggest that this alternative electron transport could compensate for the absence of mitochondrial ATP synthesis in this mutant. By elimination, our results suggest that the alternative electron transport to O2 evidenced here could be driven by a Mehler-type reaction although we did not find direct evidences for increased Mehler-type activity in low CO2 cells. Additionally from fluorescence measurements performed directly in the cultures, we concluded that low CO2 cells had a lowest PSII photosynthetic efficiency and developed strong qE NPQ. Our results indicate that Chlamydomonas reinhardtii is capable to induce an ample thermal dissipation of excitation energy and the extent of this process is influenced essentially by the CO2 availability. In contrast with results obtained in previous studies, low temperature fluorescence spectra showed that in high light, high CO2 cells were characterised by a higher proportion of light energy absorbed by PSI compared to low CO2 cells. This was accompanied by a decrease of PSII antenna size as shown by DCMU-FR measurements. These findings are discussed in relation with the conflicting theories concerning the role of state transitions in the regulation of the cyclic electron transport around PSI. Our results support the idea that CEF is regulated by the redox state of the chloroplast rather than by state transitions. Over the last decades, microalgae have been increasingly studied because of their potential applications in industry. Despite a growing interest in microalgae mass cultures, the majority of studies on microalgae have been carried out at a laboratory scale and only few studies have addressed the question of photosynthetic adaptations in mass cultures. It is well known that CO2 addition increases the growth rate of microalgae and for this reason, some mass microalgae cultures are CO2 supplemented. Among the studies on microalgae mass culture, as far as we know, none directly compared high CO2 (CO2 supplemented air) and low CO2 (air) conditions. In the last part of our work, two outdoor open thin-layer cascade systems operated as batch cultures with the alga Scenedesmus obliquus were used to compare the productivity and photosynthetic adaptations in control and CO2 supplemented cultures in relation with the outdoor light irradiance. We found that the culture productivity was limited by CO2 availability beyond a threshold of daily irradiance. In the CO2 supplemented culture, we obtained a productivity of up to 25 g dw.m-2.day-1 and found a photosynthetic efficiency of 2.6%. Fluorescence and oxygen evolution measurements showed that ETR and oxygen evolution light saturation curves, as well as alternative electron transport were similar in algal samples from both cultures when the CO2 limitation was removed. In contrast, we found that CO2 limitation conducted to a decreased PSII photochemical efficiency and an increased light-induced heat-dissipation in the control culture compared to the CO2 supplemented culture. These features may contribute to the lower productivity observed in absence of CO2 supplementation in outdoor mass cultures of Scenedesmus obliquus. [less ▲]

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See detailEpisodic memory in Alzheimer’s disease: Investigation of recollection and familiarity processes
Bastin, Christine ULg

Scientific conference (2015, March 12)

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See detailKLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression.
Ali, Amjad ULg; Zhang P; Liangfang Y et al

in cell death and disease (2015)

Inhibition of tumor suppressive signaling is linked to cancer progression, metastasis and epithelial-mesenchymal transition (EMT). Transforming growth factor-β1 (TGF-β)/Smad signaling plays an important ... [more ▼]

Inhibition of tumor suppressive signaling is linked to cancer progression, metastasis and epithelial-mesenchymal transition (EMT). Transforming growth factor-β1 (TGF-β)/Smad signaling plays an important role in tumor suppression. Kruppel-like-factor 17 (KLF17) is a negative regulator of metastasis and EMT. However, underlying mechanisms leading to tumor suppressive and anti-metastatic function of KLF17 still remains unknown. Here, we show that KLF17 plays an integral role in potentiating TGF-β/Smad signaling via Smad3-dependent pathway to suppress tumor progression. Intriguingly, TGF-β/Smad3 signaling induces KLF17 expression, generating a positive feedback loop. TGF-β/Smad3-KLF17 loop is critical for anti-metastasis and tumor inhibition in cancer cells. Mechanistically, silencing KLF17 reduced Smad3-DNA complex formation on Smad binding element (SBE) and affects the expression of TGF-β/Smad target genes. Moreover, KLF17 alters Smad3 binding pattern on chromatin. KLF17 regulates TGF-β target genes that are Smad3-dependent. Smad3 and KLF17 physically interact with each other via KLF17 responsive elements/SBE region. Intriguingly, TGF-β stimulates the recruitment of KLF17 on chromatin to subsets of metastasis-associated genes. Functionally, depletion of KLF17 enhanced tumorigenic features in cancer cells. KLF17 is critical for full cytostatic function of TGF-β/Smad signaling. Clinically, KLF17 expression significantly decreases during advance HCC. KLF17 shows positive correlation with Smad3 levels in cancer samples. Our data shows that enhance KLF17 activity has important therapeutic implications for targeted-therapies aimed at TGF-β/Smad3 pathway. These findings define novel mechanism by which TGF-β/Smad-KLF17 pathway mutually affect each other during cancer metastasis, provide a new model of regulation of TGF-β/Smad signaling by KLF17 and defines new insights into anti-metastatic function of KLF17. [less ▲]

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See detailSe "faire manger" par l'Autre. Stratégies féminines de définition de soi en contexte public.
Mescoli, Elsa ULg

Conference (2015, March 12)

Cette communication vise à étudier la participation des femmes migrantes marocaines à la vie sociale du « pays d’accueil » ; participation qui se réalise grâce aux activités de la vie quotidienne. En ... [more ▼]

Cette communication vise à étudier la participation des femmes migrantes marocaines à la vie sociale du « pays d’accueil » ; participation qui se réalise grâce aux activités de la vie quotidienne. En particulier, la performance publique des pratiques culinaires, observée dans une ville de la province de Milan, permet aux femmes considérées d’exercer une agency à l’intérieur des espaces institutionnellement concédés à l’expression des migrants. D’un côté, la consommation des « recettes de l’Autre » de la part de la population majoritaire détermine une incorporation de la diversité afin de la contrôler. De l’autre côté, la préparation de ces recettes consent aux migrantes d’exprimer leur subjectivité (individuelle et collective) de façon active et en présentant des aspects qui vont au-delà de la culture alimentaire. Une participation sociale fondée sur le partage de nourriture donne la possibilité aux femmes d’assumer un rôle actif dans la communauté locale, tout en affirmant ses propres spécificités. Des sujets tels que la liberté religieuse sont abordés, et certains droits peuvent être réclamés par des individus qui ont ainsi acquis une position politiquement importante au sein de la société locale. [less ▲]

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See detailMutant p53 promotes tumor cell malignancy by both positive and negative regulation of TGF-β pathway
Lei Ji; Jinjin Xu; Jian Liu et al

in Journal of Biological Chemistry (2015)

Specific p53 mutations abrogate the tumor suppressive functions by gaining new abilities to promote tumorigenesis. Inactivation of p53 is known to distort the TGF-β signaling, which paradoxically displays ... [more ▼]

Specific p53 mutations abrogate the tumor suppressive functions by gaining new abilities to promote tumorigenesis. Inactivation of p53 is known to distort the TGF-β signaling, which paradoxically displays both tumor-suppressive and pro-oncogenic function. The molecular mechanisms how mutant p53 simultaneously antagonizes tumor-suppressive and synergizes tumor-promoting function of TGF-β pathway remain elusive. Here we demonstrate that mutant p53 differentially regulates subsets of TGF-β target genes, by an enhanced binding to the MH2 domain in Smad3 upon the integration of ERK signaling, therefore disrupting the Smad3/Smad4 complex formation. Silencing Smad2, inhibition of ERK or introducing a phosphorylation defective mutation at Ser392 in p53 abrogates the R175H mutant p53 dependent regulation of these TGF- β target genes. Our study provide a mechanism to reconcile the seemingly contradictory observations that mutant p53 can both attenuate and cooperate with the TGF-β pathway to promote cancer cell malignancy in a same cell type. [less ▲]

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See detailConcomitant nodal involvement by Langerhans Cell Histiocytosis and Hodgkin Lymphoma
Geurten, Claire ULg; THIRY, Albert ULg; Jamblin, Paul et al

Poster (2015, March 12)

Introduction : Langerhans cell histiocytosis is defined as a clonal neoplastic proliferation of myeloid dendritic cells that upon activation migrate from the mucosal to lymph nodes. Definitive diagnosis ... [more ▼]

Introduction : Langerhans cell histiocytosis is defined as a clonal neoplastic proliferation of myeloid dendritic cells that upon activation migrate from the mucosal to lymph nodes. Definitive diagnosis is made by anatomo-pathological and immunohistochemical analysis. Langerhans cell histiocytosis is rarely, yet not exceptionally, found coexisting with other malignant neoplasms, suggesting it might arise in reaction to the cytokinic secretion of malignant cells. Case : We report the case of a 10-year-old female presenting with an isolated laterocervical lymphadenopathy and a mild general condition alteration tracing back to two months earlier. Nodal biopsy was performed and revealed concomitant involvement by Langerhans cell histiocytosis and Hodgkin lymphoma. Treatment of lymphoma led to the disappearance of the whole symptomatology. Discussion : Literature beholds reports of 30 cases of the simultaneous occurence of Hodgkin lymphoma with Langerhans cell histiocytosis, which is more than fortuitous regarding the low incidence of both diseases. A common etiology could explain such an association, but it might also be possible that background inflammatory cells of Hodgkin lymphoma stimulate the proliferation of Langerhans cells, making it a reactive process when occurring simultaneously with other neoplasms. Clinicians should thus be aware of the possibility of this association and carefully exclude any other life-threatening malignant proliferation when confronted to apparently isolated Langerhans cell histiocytosis. [less ▲]

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See detailL’intégration des Marocains en Belgique, un processus tripartite
Gsir, Sonia ULg

Conference (2015, March 12)

Detailed reference viewed: 14 (0 ULg)