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See detailThe SarcoPhAge study: evolution of sarcopenic subjects after 2 years of follow-up.
Beaudart, Charlotte ULg; Locquet, Médéa ULg; Reginster, Jean-Yves ULg et al

in Osteoporosis International (2017, March), 28 Suppl 1

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See detailPrevalence of sarcopenia accoring to 10 different operational definitions of the frailty.
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Beaudart, Charlotte ULg et al

in Osteoporosis International (2017, March), 28 Suppl 1

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See detailBiomarkers of osteoarthritis : practical considerations.
CAVALIER, Etienne ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2017, March), 28 Suppl 1

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See detailDaily management of knee osteoarthritis: from the ESCEO algorithm to the CONCEPT study.
Reginster, Jean-Yves ULg

in Osteoporosis International (2017, March), 28 Suppl 1

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See detailLésions mixtes des mâchoires, radio-opaques et radio-transparentes
MILICEVIC, Mladen ULg

in Revue Médicale de Liège (2017), 72(3), 151-155

Les Lésions néoplasiques et non néoplasiques des mâchoires sont généralement classifiées comme radio-opaques ou radio-transparentes, odontogènes ou non odontogènes. Toutefois, il existe un nombre ... [more ▼]

Les Lésions néoplasiques et non néoplasiques des mâchoires sont généralement classifiées comme radio-opaques ou radio-transparentes, odontogènes ou non odontogènes. Toutefois, il existe un nombre significatif de pathologies qui peuvent être classifiées comme étant mixtes ou qui, au départ, sont radio-transparentes et deviennent ultérieurement radio-opaques ou mixtes. certaines pathologies s'expriment en différents stades de développement qui sont radio-transparents, radio-opaques ou mixtes. Le but de cet article est d'apporter une meilleure compréhension de l'imagerie de ces lésions, fondée sur une revue de la littérature, illustrée par des images de cas cliniques personnels. [less ▲]

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See detailL'acte d'imagination: Approches phénoménologiques
Hagelstein, Maud ULg; Hervy, Alievtina ULg; Leclercq, Bruno ULg

in Bulletin d'Analyse Phénoménologique (2017), 13 (2017)(2),

Du 25 au 29 avril 2016, le centre « Phénoménologies » de l’Université de Liège a tenu la dixième édition de son séminaire international de recherche en phénoménologie. Autour du thème général L’Acte ... [more ▼]

Du 25 au 29 avril 2016, le centre « Phénoménologies » de l’Université de Liège a tenu la dixième édition de son séminaire international de recherche en phénoménologie. Autour du thème général L’Acte d’imagination : approches phénoménologiques, vingt-huit chercheurs issus de vingt-deux universités différentes se sont rencontrés pendant une semaine entière pour discuter dans le détail plusieurs aspects de la problématique. Le volume actuel reprend la plupart des communications qui avaient été présentées durant cette semaine, communications ici retravaillées pour intégrer les propositions qu’avaient suscitées leur présentation originale et plus généralement l’ensemble des débats très riches qu’avait permis la constitution ponctuelle d’une vraie communauté philosophique. Kant avait notoirement fait de la faculté d’imagination un intermédiaire (un peu indécis) entre la réceptivité de l’expérience sensible et la spontanéité de l’entendement. En s’installant plus nettement sur le terrain de la psychologie descriptive et en abandonnant le vocabulaire des « facultés » pour lui préférer celui des actes mentaux ou des fonctions psychiques, les brentaniens s’étaient donné les moyens d’analyser plus finement les composantes de l’acte d’imagination (mode de visée, contenu réel, contenu intentionnel...), les rapports de fondation qu’il entretient avec d’autres types d’actes, et par là le rôle qu’il peut jouer dans les fonctions cognitives ou évaluatives de l’esprit. C’est de cet acte d’imagination, envisagé par la phénoménologie en tant que psychologie descriptive, qu’il sera ici question. [less ▲]

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See detailLA THÉRAPIE MANUELLE ORTHOPÉDIQUE : définition, caractéristiques et mise au point sur la situation en Belgique
Demoulin, Christophe ULg; Depas, Yannick ULg; Vanderthommen, Marc ULg et al

in Revue Médicale de Liège (2017), 72(3), 126-131

Orthopaedic manual therapy : definition, characteristics and update on the situation in Belgium Summary : Although orthopaedic manual therapy (OMT) has existed for decades, and although a recent Belgian ... [more ▼]

Orthopaedic manual therapy : definition, characteristics and update on the situation in Belgium Summary : Although orthopaedic manual therapy (OMT) has existed for decades, and although a recent Belgian Royal Decree, published in 2014, recognized it as a particular professional qualification in physiotherapy for the treatment of neuromusculoskeletal dysfunctions, OMT remains little known by patients, but also by healthcare professionals. Yet, this professional qualification, based on clinical reasoning, using highly specific treatments, guided by the best available scientific and clinical evidence and the specific biopsychosocial characteristics of each patient, is the subject of a growing number of scientific studies pointing out its effectiveness. This article summarizes the knowledge related to OMT (definition, history, characteristics, techniques, indications, access and reimbursement) and describes its situation in Belgium. [less ▲]

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See detail2 Years outcome of patients in unresponsive wakefulness syndrome/vegetative state and minimally conscious state
Cassol, Helena ULg; LEDOUX, Didier ULg; Thibaut, Aurore ULg et al

Poster (2017, March)

INTRODUCTION: Following severe acute brain damage, patients typically evolve from coma to an unresponsive wakefulness syndrome/vegetative state (UWS/VS; wakefulness without awareness) and later to a ... [more ▼]

INTRODUCTION: Following severe acute brain damage, patients typically evolve from coma to an unresponsive wakefulness syndrome/vegetative state (UWS/VS; wakefulness without awareness) and later to a minimally conscious state (MCS; fluctuating but consistent nonreflex behaviors). MCS is subcategorized in MCS+ (i.e., command following) and MCS- (i.e., visual pursuit, localization of noxious stimulation or contingent behaviours). Reliable and consistent interactive communication and/or functional use of objects indicate the next boundary – emergence from MCS (EMCS). To date, there is still no reliable predictive model of recovery from the UWS/VS and the MCS. A better understanding of patients' outcome would help in decisions regarding patients’ care and rehabilitation, as well as end-of-life decisions. METHODS: We collected demographic information, acute care history and longitudinal follow-up of patients in UWS/VS and MCS admitted in 15 expert centers in Belgium (via the Belgian Federal Public Service Health). Patients were evaluated at 1, 3, 6, 12 and 24 months post injury with the Coma Recovery Scale-Revised and the diagnosis was based on internationally accepted criteria of UWS/VS, MCS or EMCS. Results were considered significant at p<0.001. RESULTS: 24 months follow-up was available for 476 patients including 261 diagnosed in UWS/VS (88 traumatic, 173 non-traumatic) and 215 diagnosed in MCS (80 traumatic, 135 non-traumatic) one month after the injury. Patients who were in MCS one month after the insult were more likely to recover functional communication or object use after 24 months than patients in UWS/VS. Moreover, functional recovery occurred more often in MCS+ (79%) as compared to MCS- (29%), and mortality rate was more important in MCS- patients (68%) as compared to MCS+ (21%). Comparisons within UWS/VS and MCS groups based on etiology showed that traumatic patients had a better outcome at 24 months than non-traumatic patients. Among non-traumatic patients, no difference was found between anoxic patients and patients with other etiologies regarding functional recovery. CONCLUSION: Our study highlights that the outcome is significantly better for patients who are in MCS one month post-injury as compared to patients who remain in UWS/VS at that time. Concerning MCS patients, the outcome is significantly better for patients who are MCS+ one month post-injury as compared to patients who are MCS- at that time. This study also confirms that patients with traumatic etiology have better prognosis than patients with non-traumatic causes. [less ▲]

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See detailMassivement histologique : entre continuité et (r)évolution pédagogique. Lancement du premier Massive Open Online Course (MOOC) sur des travaux pratiques en Histologie à destination de nos étudiants mais aussi du grand public.
Multon, Sylvie ULg; Pesesse, Laurence ULg; Weatherspoon, Alodie ULg et al

Poster (2017, March)

L’acronyme anglophone MOOC désigne les « Massive Open Online Courses » que l’on pourrait traduire par « formation en ligne massive ouverte à tous ». Nés aux États-Unis avec un programme sur l’intelligence ... [more ▼]

L’acronyme anglophone MOOC désigne les « Massive Open Online Courses » que l’on pourrait traduire par « formation en ligne massive ouverte à tous ». Nés aux États-Unis avec un programme sur l’intelligence artificielle dispensé par l’université de Stanford, ces cours en ligne accessibles gratuitement font miroiter la possibilité d’une démocratisation maximale des savoirs. A ce titre, les MOOC bénéficient des innovations issues du Web 2.0 : ils tirent le meilleur de la rencontre entre les nouveaux usages induits par les réseaux sociaux et les apports de la pédagogique active. Ces cinq dernières années, nous avons dispensé les travaux pratiques en Histologie aux premières années d’étude de la faculté de Médecine de l’Université de Liège par une méthodologie hybride alliant les bénéfices d’un enseignement à distance et ceux de séances menées en face-à-face (Multon et al., 2015). Notre dispositif d’auto-apprentissage invite chaque année plus de 500 étudiants à parcourir plusieurs coupes d’organes digitalisées afin de découvrir les structures histologiques pointées par des balises interactives pour chaque grande famille de tissus. La mise en ligne d’un MOOC dédié aux travaux pratiques d’Histologie s’inscrit dans une suite logique de nos activités avec une volonté de donner accès à nos ressources numériques à un public plus large. « Découvrir les tissus fondamentaux du corps humain en explorant par vous même des lames histologiques au microscope », tel est le programme de notre MOOC intitulé « Introduction à l’histologie, exploration des tissus du corps humain ». Celui-ci a débuté en février 2017 et est hébergé sur la plate-forme FUN encadrée par le ministère de l’Enseignement supérieur et de la Recherche du ministère français (https://www.fun-mooc.fr/courses/ulg/108001/session01/about). Ce MOOC s’adresse à un public large : aux étudiants ou futurs étudiants dans le domaine médical, paramédical ou scientifique, aux enseignants, chercheurs, professionnels dans le secteur de la santé, décideurs dans le domaine de l’éducation ou de la santé ou simplement aux curieux désireux de comprendre à partir de quoi le corps humain est construit. Deux parcours pédagogiques permettant d’approfondir différemment la matière sont proposés pour correspondre au mieux aux objectifs ou motivations de chacun. Au travers de vidéos explicatives contenant des dessins réalisés sous vos yeux et des liens avec l’anatomie suivie d’activités interactives telles que la manipulation d’un microscope virtuel, de nombreux quiz et d’activités réalisées avec les pairs, les participants seront capables de reconnaître les différents types de cellules et tous les éléments qui les entourent afin de comprendre comment ils s’organisent entre eux pour former des tissus aux fonctions spécifiques. Une recherche est actuellement en cours sur l’étude des traces d’activités des participants au MOOC en fonction du parcours pédagogique choisi afin d’évaluer notamment l’impact des différentes composantes de l’expérience d’apprentissage. [less ▲]

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See detailAnalytical and clinical validation of the new Abbot Architect 25(OH)D assay: fit for purpose?
Cavalier, Etienne ULg; LUKAS, Pierre ULg; BEKAERT, Anne-Catherine ULg et al

in Clinical Chemistry & Laboratory Medicine (2017), 55(3), 378-384

BACKGROUND: We provide a clinical and analytical evaluation of the reformulated version of the Abbott Architect 25-hydroxyvitamin D assay. We compared this assay with three commercial automated ... [more ▼]

BACKGROUND: We provide a clinical and analytical evaluation of the reformulated version of the Abbott Architect 25-hydroxyvitamin D assay. We compared this assay with three commercial automated immunoassays and against a VDSP-traceable liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in six different populations. We also supplemented 40 healthy volunteers with either 600,000 IU of vitamin D2 or 100,000 of vitamin D3 to evaluate the performance of the immunoassays vs. the LC-MS/MS. METHODS: Precision and limit of quantification were assessed, 25(OH)D2 and C3-epimer recovery were calculated. Two hundred and forty samples obtained in healthy Caucasians and Africans, osteoporotic, hemodialyzed and intensive care patients and 3rd trimester pregnant women were analyzed by all methods. Correlation was studied using Passing-Bablok and Bland-Altman analysis. Concordance correlation coefficient (CCC) was calculated to evaluate agreement between immunoassays and LC-MS/MS. We verified if patients were homogeneously classified with the immunoassays when they took vitamin D2 or vitamin D3 after 1, 7 and 28 days. RESULTS: We observed excellent analytical features and showed a very good correlation to the LC-MS/MS results in the overall population. Compared to the other immunoassays, concordance of the new Abbott assay with the LC-MS/MS was at least similar, and often better in diseased populations. Althought the cross-reactivity with 25(OH)D2 was not of 100%, there was no significant difference in the classifications of the patients, either supplemented with D2 or D3 or after 7 or 28 days. CONCLUSIONS: This modified version of the Abbott Architect assay is clearly improved compared to the previous one and presents a better agreement with the LC-MS/MS. [less ▲]

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See detailEU competition law
Van Cleynenbreugel, Pieter ULg

in Ugirashebuja, Emmanuel; Ruhangisa, John Eures; Ottervanger, Tom (Eds.) et al East African Community Law: institutional, substantive and comparative EU aspects (2017)

This chapter provides an overview of the principles of EU competition law, its relationship to EU internal market law and the similarities and differences between this body of law and East African ... [more ▼]

This chapter provides an overview of the principles of EU competition law, its relationship to EU internal market law and the similarities and differences between this body of law and East African competition law. [less ▲]

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See detailEnglish translation and validation of the SarQoL®, a quality of life questionnaire specific for sarcopenia
Beaudart, Charlotte ULg; Edwards, Mark; Moss, Charlotte et al

in Age & Ageing (2017), 46(2), 271-7

Background: the first quality of life questionnaire specific to sarcopenia, the SarQoL®, has recently been developed and validated in French. To extend the availability and utilisation of this ... [more ▼]

Background: the first quality of life questionnaire specific to sarcopenia, the SarQoL®, has recently been developed and validated in French. To extend the availability and utilisation of this questionnaire, its translation and validation in other languages is necessary. Objective: the purpose of this study was therefore to translate the SarQoL® into English and validate the psychometric properties of this new version. Design: cross-sectional. Setting: Hertfordshire, UK. Subjects: in total, 404 participants of the Hertfordshire Cohort Study, UK. Methods: the translation part was articulated in five stages: (i) two initial translations from French to English; (ii) synthesis of the two translations; (iii) backward translations; (iv) expert committee to compare the backward translations with the original questionnaire and (v) pre-test. To validate the English SarQoL®, we assessed its validity (discriminative power, construct validity), reliability (internal consistency, test–retest reliability) and floor/ceiling effects. Results: the SarQoL® questionnaire was translated without any major difficulties. Results indicated a good discriminative power (lower score of quality of life for sarcopenic subjects, P = 0.01), high internal consistency (Cronbach’s alpha of 0.88), consistent construct validity (high correlations found with domains related to mobility, usual activities, vitality, physical function and low correlations with domains related to anxiety, self-care, mental health and social problems) and excellent test–retest reliability (intraclass coefficient correlation of 0.95, 95%CI 0.92–0.97). Moreover, no floor/ceiling has been found. Conclusions: a valid SarQoL® English questionnaire is now available and can be used with confidence to better assess the disease burden associated with sarcopenia. It could also be used as a treatment outcome indicator in research. [less ▲]

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See detailLocal Identification of Voltage Instability from Load Tap Changer Response
Weckesser, Johannes ULg; Papangelis, Lampros ULg; Vournas, Costas et al

in Sustainable Energy, Grids and Networks (2017)

This paper presents a local long-term voltage instability monitoring method, which is suitable for on-line applications. The proposed extended-time Local Identification of Voltage Emergency Situations ... [more ▼]

This paper presents a local long-term voltage instability monitoring method, which is suitable for on-line applications. The proposed extended-time Local Identification of Voltage Emergency Situations (eLIVES) method is a significantly modified version of the previously presented LIVES method. The new method is not bound to assessing system response over a predefined LTC tapping period. This allows handling LTCs with variable delays, as well as events taking place during the tapping sequence impacting the distribution voltages. For that purpose, eLIVES applies recursive least square fitting to acquired distribution voltage measurements and a new set of rules to detect a voltage emergency situation. The effectiveness of the eLIVES method is presented on the IEEE Nordic test system for voltage stability and security assessment. [less ▲]

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See detailDifferentiation of patented crystalline glucosamine sulfate from other glucosamine preparations will optimize osteoarthritis treatment.
Saengnipanthkul, Sukit; Waikakul, Saranatra; Rojanasthien, Sattaya et al

in International Journal of Rheumatic Diseases (2017)

Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and ... [more ▼]

Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and delay joint structural changes. Among SYSADOAs, evidence is greatest for the patented crystalline glucosamine sulfate (pCGS) formulation (Mylan). Glucosamine is widely available as glucosamine sulfate (GS) and glucosamine hydrochloride (GH) preparations that vary substantially in molecular form, pharmaceutical formulation and dose regimen. Only pCGS is given as a highly bioavailable once-daily dose (1500 mg), which consistently delivers the plasma levels of around 10 mumol/L required to inhibit interleukin-1-induced expression of genes involved in the pathophysiology of joint inflammation and tissue destruction. Careful consideration of the evidence base reveals that only pCGS reliably provides a moderate effect size on pain that is higher than paracetamol and equivalent to non-steroidal anti-inflammatory drugs (NSAIDs), while non-crystalline GS and GH fail to reach statistical significance for pain reduction. Chronic administration of pCGS has disease-modifying effects, with a reduction in need for total joint replacement lasting for 5 years after treatment cessation. Pharmacoeconomic studies of pCGS demonstrate long-term reduction in additional pain analgesia and NSAIDs, with a 50% reduction in costs of other OA medication and healthcare consultations. Consequently, pCGS is the logical choice, with demonstrated medium-term control of pain and lasting impact on disease progression. Physician and patient education on the differentiation of pCGS from other glucosamine formulations will help to improve treatment selection, increase treatment adherence, and optimize clinical benefit in OA. [less ▲]

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See detailProteomic response of Macrobrachium rosenbergii hepatopancreas exposed to chlordecone: Identification of endocrine disruption biomarkers?
Lafontaine, Anne ULg; Baiwir, Dominique ULg; Joaquim-Justo, Célia ULg et al

in Ecotoxicology and Environmental Safety (2017), 141

The present work is the first study investigating the impacts of chlordecone, an organochlorine insecticide, on the proteome of the decapod crustacean Macrobrachium rosenbergii, by gel-free proteomic ... [more ▼]

The present work is the first study investigating the impacts of chlordecone, an organochlorine insecticide, on the proteome of the decapod crustacean Macrobrachium rosenbergii, by gel-free proteomic analysis of the hepatopancreas protein expression variations in organisms exposed to three environmental relevant concentrations of chlordecone (i.e. 0.2, 2 and 20 μg/L). Results revealed that 62 proteins were significantly up- or down-regulated in exposed prawns compared to controls. Most of these proteins are involved in important physiological processes such as ion transport, defense mechanisms and immune system, cytoskeleton dynamics, or protein synthesis and degradation. Moreover, it appears that 6% of the deregulated protein are involved in the endocrine system and in the hormonal control of reproduction or development processes of M. rosenbergii (e.g. vitellogenin, farnesoic acid omethyltransferase). These results indicate that chlordecone is potentially an endocrine disruptor compound for decapods, as already observed in vertebrates. These protein modifications could lead to disruptions of growth and reproduction of M. rosenbergii, and therefore of the fitness population on the long-term. Besides, these disrupted proteins could be suggested as biomarkers of exposure for endocrine disruptions in invertebrates. However, further investigations are needed to complete understanding of action mechanisms of chlordecone on proteome and endocrine system of crustaceans. [less ▲]

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See detailMicro-mechanical testing of magnesium based composites reinforced by carbon fibers manufactured by friction stir processing
Simar, Aude; Ryelandt, Sophie; Delannay, Francis et al

Conference (2017, February 28)

Short C fibres–Mg matrix (AZ91D) composites have been produced by friction stir processing sandwiches made of a layer of C fabric stacked between two sheets of Mg alloy. The process parameters have been ... [more ▼]

Short C fibres–Mg matrix (AZ91D) composites have been produced by friction stir processing sandwiches made of a layer of C fabric stacked between two sheets of Mg alloy. The process parameters have been optimized to ensure a good fiber distribution. 3D X-ray tomography reveals that the fibers orient like onion rings. Thermal treatments have allowed to modify the flow stress level of the matrix material. Tensile testing inside the scanning electron microscope have revealed the decohesion at the fiber/matrix interface if the fibers are preferentially oriented perpendicularly to the loading direction. Modelling allows to estimate the stress needed to initiate this decohesion is about 250 MPa, i.e. appearing early in heat treated samples. To compare with different loading conditions, micro-compression and instrumented micro-indentation testing have also been performed. The consequence of the loading path on the decohesion is discussed. [less ▲]

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See detailShort-Term Local Adaptation of Historical Common Bean (Phaseolus vulgaris L.) Varieties and Implications for In Situ Management of Bean Diversity
Klaedtke, Stephanie ULg; Caproni, Leonardo; Klauck, Julia et al

in International Journal of Molecular Sciences (2017), 18

Recognizing both the stakes of traditional European common bean diversity and the role farmers’ and gardeners’ networks play in maintaining this diversity, the present study examines the role that local ... [more ▼]

Recognizing both the stakes of traditional European common bean diversity and the role farmers’ and gardeners’ networks play in maintaining this diversity, the present study examines the role that local adaptation plays for the management of common bean diversity in situ. To the purpose, four historical bean varieties and one modern control were multiplied on two organic farms for three growing seasons. The fifteen resulting populations, the initial ones and two populations of each variety obtained after the three years of multiplication, were then grown in a common garden. Twenty-two Simple Sequence Repeat (SSR) markers and 13 phenotypic traits were assessed. In total, 68.2% of tested markers were polymorphic and a total of 66 different alleles were identified. FST analysis showed that the genetic composition of two varieties multiplied in different environments changed. At the phenotypic level, differences were observed in flowering date and leaf length. Results indicate that three years of multiplication suffice for local adaptation to occur. The spatial dynamics of genetic and phenotypic bean diversity imply that the maintenance of diversity should be considered at the scale of the network, rather than individual farms and gardens. The microevolution of bean populations within networks of gardens and farms emerges as a research perspective. [less ▲]

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