Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailMeasurement of urinary biomarkers of parabens, benzophenone-3 and phthalates in a Belgian population
Dewalque, Lucas ULg; PIRARD, Catherine ULg; Charlier, Corinne ULg

in BioMed Research International (2014), 2014(Article ID 649314,), 1-13

Parabens, benzophenone-3 (BP3) and phthalates are commonly used as antimicrobial conservator, UV-filter and plasticizer respectively, and are thought to exhibit endocrine disrupting properties. These ... [more ▼]

Parabens, benzophenone-3 (BP3) and phthalates are commonly used as antimicrobial conservator, UV-filter and plasticizer respectively, and are thought to exhibit endocrine disrupting properties. These endocrine disrupting activities have been recently assumed to lead to cutaneous malignant melanoma. Humans are exposed to these chemicals through different sources such as food, personal care products or cosmetics. In this study we measured urinary levels of 4 parabens, BP3 and 7 metabolites of phthalates in samples collected from 261 participants living in and around Liege (Belgium). The analyses were carried out by liquid chromatography tandem mass spectrometry (LC-MS/MS) using isotopic dilution. To the best of our knowledge, this is the first time that the urinary levels of these 3 classes of chemicals are reported for the same general population in Belgium. Most of the parabens, the BP3 and all the phthalate metabolites were detected in 82.8 to 100.0% of the samples. For most of these chemicals, the exposure patterns significantly differ between children and adults, but also between males and females, especially with higher concentrations of parabens and phthalate metabolites in female and children subjects respectively. [less ▲]

Detailed reference viewed: 24 (14 ULg)
Full Text
Peer Reviewed
See detailEpigenetic modulators mitigate angiogenesis through a complex transcriptomic network
Shiva Shankar, T.V.; Willems, Luc ULg

in Vascular Pharmacology (2014), 60

In this review, we summarize the knowledge pertaining to the role of epigenetics in the regulation of angiogenesis. In particular, we show that lysine acetylation and cytosine methylation are important ... [more ▼]

In this review, we summarize the knowledge pertaining to the role of epigenetics in the regulation of angiogenesis. In particular, we show that lysine acetylation and cytosine methylation are important transcriptional regulators of angiogenic genes in endothelial cells. Lysine acetylation and cytosine methylation inhibitors idiosyncratically tune the transcriptome and affect expression of key modulators of angiogenesis such as VEGF and eNOS. Transcriptomic profiling also reveals a series of novel genes that are concomitantly affected by epigenetic modulators. The reversibility and overall tolerability of currently available epigenetic inhibitors open up the prospect of therapeutic intervention in pathologies where angiogenesis is exacerbated. This type of multitargeted strategy has the major advantage of overcoming the compensatory feedback mechanisms that characterize single anti-angiogenic factors. [less ▲]

Detailed reference viewed: 8 (0 ULg)
See detailLa politique énergétique de l'Union européenne
Habran, Maxime ULg

Learning material (2014)

Il s'agit d'un cours sur l'introduction de la politique énergétique de l'UE. Il se compose de quatre parties. L'énergie européenne en quelques chiffres; Les multiples aspects de la politique énergétique ... [more ▼]

Il s'agit d'un cours sur l'introduction de la politique énergétique de l'UE. Il se compose de quatre parties. L'énergie européenne en quelques chiffres; Les multiples aspects de la politique énergétique; Les aspects extérieures de la politique énergétique; Comment produire autrement? [less ▲]

Detailed reference viewed: 28 (4 ULg)
Full Text
See detail7. Lutte intégrée contre les ravageurs
Chavalle, Sandrine; Censier, Florence ULg; Jacquemin, Guillaume et al

in Destain, Jean-Pierre; Bodson, Bernard (Eds.) Livre Blanc Céréales (2014, February)

Detailed reference viewed: 27 (2 ULg)
Full Text
Peer Reviewed
See detailA Super-Jupiter orbiting a late-type star: A refined analysis of microlensing event OGLE-2012-BLG-0406
Tsapras, Y.; Choi, J.-Y.; Street, R. A. et al

in Astrophysical Journal (2014), 782

We present a detailed analysis of survey and follow-up observations of microlensing event OGLE-2012-BLG-0406 based on data obtained from 10 different observatories. Intensive coverage of the lightcurve ... [more ▼]

We present a detailed analysis of survey and follow-up observations of microlensing event OGLE-2012-BLG-0406 based on data obtained from 10 different observatories. Intensive coverage of the lightcurve, especially the perturbation part, allowed us to accurately measure the parallax effect and lens orbital motion. Combining our measurement of the lens parallax with the angular Einstein radius determined from finite-source effects, we estimate the physical parameters of the lens system. We find that the event was caused by a $2.73\pm 0.43\ M_{\rm J}$ planet orbiting a $0.44\pm 0.07\ M_{\odot}$ early M-type star. The distance to the lens is $4.97\pm 0.29$\ kpc and the projected separation between the host star and its planet at the time of the event is $3.45\pm 0.26$ AU. We find that the additional coverage provided by follow-up observations, especially during the planetary perturbation, leads to a more accurate determination of the physical parameters of the lens. [less ▲]

Detailed reference viewed: 18 (3 ULg)
Full Text
Peer Reviewed
See detailAdrenomedullin refines mortality prediction by the BODE index in COPD - The "BODE-A" index.
Stolz, Daiana; Kostikas, Kostantinos; Blasi, Francesco et al

in European Respiratory Journal (2014)

The BODE index is well-validated for mortality prediction in COPD. Concentrations of plasma proadrenomedullin, a surrogate for mature adrenomedullin, independently predicted 2-year mortality among ... [more ▼]

The BODE index is well-validated for mortality prediction in COPD. Concentrations of plasma proadrenomedullin, a surrogate for mature adrenomedullin, independently predicted 2-year mortality among inpatients with COPD exacerbation.We compared accuracy of initial proadrenomedullin level, BODE, and BODE components, alone or combined, in predicting 1-year or 2-year all-cause mortality in a multicenter, multinational observational cohort with stable, moderate to very severe COPD.Proadrenomedullin was significantly associated (P<0.001) with 1-year mortality (4.7%) and 2-year mortality (7.8%), and comparably predictive to BODE regarding both (C statistics: 0.691 vs. 0.745, 0.635 vs. 0.679). Relative to using BODE alone, adding proadrenomedullin significantly improved 1-year and 2-year mortality prognostication (C statistics: 0.750, 0.818; both P<0.001). Proadrenomedullin plus BOD was more predictive than was the original BODE including 6-minute-walk distance. In multivariable analysis, proadrenomedullin (LR X2 13.0, P<0.001), body mass index (8.5, P=0.004), and 6-minute-walk distance (7.5, P=0.006), but not modified MMRC dyspnoea score (2.2, P=0.14) or FEV1 % predicted (0.3, P=0.60), independently foretold 2-year survival.Proadrenomedullin plus BODE better predicts mortality in COPD patients than does BODE alone; proadrenomedullin may substitute for 6-minute-walk distance in BODE when 6-minute-walk testing is unavailable. [less ▲]

Detailed reference viewed: 4 (0 ULg)
See detailL’aporie de la mathématisation de la physique en contexte aristotélicien
Dubouclez, Olivier ULg

Scientific conference (2014, February)

Detailed reference viewed: 9 (0 ULg)
Full Text
See detailSubspace and nonlinear-normal-modes-based identification of a beam with softening-hardening behaviour
Grappasonni, Chiara ULg; Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg

in Proceedings of the International Modal Analysis Conference (IMAC) XXXII (2014, February)

The capability to reproduce and predict with high accuracy the behaviour of a real system is a fundamental task of numerical models. In nonlinear structural dynamics, additional parameters compared to ... [more ▼]

The capability to reproduce and predict with high accuracy the behaviour of a real system is a fundamental task of numerical models. In nonlinear structural dynamics, additional parameters compared to classical linear modelling, which include the nonlinear coefficient and the mathematical form of the nonlinearity, need to be identified to bring the numerical predictions in good agreement with the experimental observations. In this context, the present paper presents a method for the identification of an experimental cantilever beam with a geometrically nonlinear thin beam clamped with a prestress, hence giving rise to a softening-hardening nonlinearity. A novel nonlinear subspace identification method formulated in the frequency domain is first exploited to estimate the nonlinear parameters of the real structure together with the underlying linear system directly from the experimental tests. Then a finite element model, built from the estimated parameters, is used to compute the backbone of the first nonlinear normal mode motion. These numerical evaluations are compared to a nonlinear normal modes-based identification of the structure using system responses to stepped sine excitation at different forcing levels. [less ▲]

Detailed reference viewed: 66 (17 ULg)
Full Text
See detailLes grands principes de l'aménagement du territoire
Habran, Maxime ULg

Learning material (2014)

Il s'agit d'une introduction aux principes en matière d'aménagement du territoire. Cette leçon a pour but d'expliquer les principales démarches à effectuer dans le cadre d'une demande d'urbanisme.

Detailed reference viewed: 18 (0 ULg)
Full Text
Peer Reviewed
See detailQuasicontinuum study of the shear behavior of defective tilt grain boundaries in Cu
Péron-Lührs, Vincent ULg; Sansoz, Frédéric; Noels, Ludovic ULg

in Acta Materialia (2014), 64

Atomistic simulations using the quasicontinuum method are used to study the role of vacancy defects and angström-scale voids on the mechanical behavior of five tilt bicrystals containing grain boundaries ... [more ▼]

Atomistic simulations using the quasicontinuum method are used to study the role of vacancy defects and angström-scale voids on the mechanical behavior of five tilt bicrystals containing grain boundaries (GBs) that have been predicted to exhibit characteristic deformation processes of nanocrystalline and nanotwinned metals: GB-mediated dislocation emission, interface sliding, and shear-coupled GB migration. We demonstrate that such nanoscale defects have a profound impact on interfacial shear strength and underlying deformation mechanisms in copper GBs due to void-induced local stresses. In asymmetric high and low angle GBs, we find that voids become preferential sites for dislocation nucleation when the void size exceeds 4 Å. In symmetric 9(221) GBs prone to sliding, voids are shown to shield the local shear stress, which considerably reduces the extent of atom shuffling at the interface. In symmetric Sigma5(210) and Sigma27(115) GBs, we find that the effect of voids on shear-coupled GB migration depends on the GB tilt direction considered, as well as on the size and number of voids. Remarkably, large voids can completely abate the GB migration process in Sigma 27(115) GBs. For all GB types, the interfacial shear strength is shown to decrease linearly as the volume fraction of voids at the interface increases; however, this study also suggests that this decrease is much more pronounced in GBs deforming by sliding than by dislocation nucleation or migration, owing to larger void-induced stresses. [less ▲]

Detailed reference viewed: 84 (26 ULg)
Full Text
Peer Reviewed
See detailContribution of Spray Droplet Pinning Fragmentation to Canopy Retention
Boukhalfa, Hassina dite Hafida ULg; Massinon, Mathieu ULg; Belhamra, Mohamed et al

in Crop Protection (2014), 56

Drop behaviour during impact affects retention. The increase of adhesion is usually seen as the objective when applying crop protection products, while bouncing and shattering are seen as detrimental to ... [more ▼]

Drop behaviour during impact affects retention. The increase of adhesion is usually seen as the objective when applying crop protection products, while bouncing and shattering are seen as detrimental to spray retention. However, observation of drop impacts on barley (Hordeum vulgare L.) using high speed shadowgraphy shows that bouncing and fragmentation can occur in Cassie-Baxter as well as in Wenzel wetting regimes. In this last regime, a part of the drop may remain stuck on the surface, contributing to retention. Using simultaneous measurements of drop impacts with high speed imaging and of retention with fluorophotometry for spray mixtures on excised barley leaves using a Teejet 11003 nozzle at 0.2 MPa, it is observed that about 50% of the drops that fragmented in the Wenzel state remain on the horizontal leaf. Depending on the spray mixture, these impact outcomes accounted for 28 to 46% of retention, the higher contribution being correlated with bigger VMD (Volume Median Diameter). This contribution is not negligible and should be considered when modelling spray retention processes. [less ▲]

Detailed reference viewed: 49 (18 ULg)
Full Text
Peer Reviewed
See detailObservation <–> Text(e) <–> Culture
Badir, Sémir ULg

in Semiotica (2014), 198

Detailed reference viewed: 23 (4 ULg)
Full Text
See detailMicrofluidic on optical fibers: Towards a new kind of fluorescent biosensor
Lismont, Marjorie ULg; Vandewalle, Nicolas ULg; Weyer, Floriane ULg et al

Poster (2014, February)

In recent works, the behavior of droplets moving along vertical treads due to gravity was studied. It appeared that the droplet can be stopped by encountering a horizontal fiber depending on droplet ... [more ▼]

In recent works, the behavior of droplets moving along vertical treads due to gravity was studied. It appeared that the droplet can be stopped by encountering a horizontal fiber depending on droplet volumes and fiber characteristics. On the basis of this behavior and by replacing treads by two crossed optical fibers, it is possible to combine fluidics and optics to develop a new kind of fluorescent sensor. In our work, the intersection between two crossed optical fibers is used as the basic unit of an original optofluidic biosensor. These two optical fibers are used as droplets carriers: one for probe molecules and the other one for target species. The fiber's junction catches the droplets and act as a reaction center. The main advantage of using optical fibers resides in their ability to propagate and collect light to and from the droplet localized at the fiber's crossing. This optical fiber configuration can therefore allow the study of biological interactions using fluorescent labels. This new and versatile detection scheme was validated on a calcium indicator where ions detection is accomplished by using a dye, Oregon green Bapta-2, that has a Ca 2+ recognition group as well as an entity exhibiting fluorescence. A FRET recognition event, between Rh-Con A and FITC-Dextran, was also investigated to detect glucose. Finally, a prototype of a multiplexing device, composed of several juxtaposed fibers' junctions, was developed. [less ▲]

Detailed reference viewed: 48 (11 ULg)
Full Text
Peer Reviewed
See detailMetal Enhanced Fluorescence: effect of surface coating
Lismont, Marjorie ULg; François, Alexandre; Dreesen, Laurent ULg et al

in SPIE proceeding (2014, February)

Among the emerging treatments for cancer, Photodynamic Therapy (PDT) is thought to be one of the most promising. PDT uses light sensitive molecules, or photosensitizer, to produce, under specific ... [more ▼]

Among the emerging treatments for cancer, Photodynamic Therapy (PDT) is thought to be one of the most promising. PDT uses light sensitive molecules, or photosensitizer, to produce, under specific irradiation, toxic reactive oxygen species (ROS) to kill cancer cells. However, the amount of ROS generated is limited by both the fluorescence lifetime of the photosensitizer and its concentration around the cancer cells. Metal Enhanced Fluorescence (MEF), a phenomenon arising when a fluorophore is in closed proximity to a metallic structure such as metallic films or nanostructures, is seen as a way to solve these problems by reducing the fluorescence lifetime and increasing the fluorescence emission of the fluorophore. Protoporphyrin IX (PpIX) is a commonly used photosensitizer to treat skin cancers, which presents an intense absorption band around 400 nm while emitting around 630 nm. Because silver nanoparticles (Ag NPs) exhibit a strong Localized Surface Plasmon Resonance (LSPR) around 400 nm, MEF of the PpIX is expected when immobilized onto Ag NPs. Here, we investigate the relevant parameters influencing the coupling effects between the LSPR in Ag NPs and PpIX attached onto the Ag NPs surface when the Ag NPs are dispersed in solution or electrostatically bound to a glass slide. In particular, we study the distance-dependent of MEF by applying multiple layers of polyelectrolyte to progressively increase the distance between Ag NPs and PpIX, covalently bond to the last polyelectrolyte layer as well as exploring the use of Ag NPs of different sizes ranging from 40 to 100 nm. [less ▲]

Detailed reference viewed: 47 (10 ULg)
Full Text
See detailArts et sciences. Approches sémiotiques et philosophiques des images
Dondero, Maria Giulia ULg; Beyaert-Geslin, Anne

Book published by Presses universitaires de Liège (2014)

Les images artistiques et scientifiques se ressemblent en de nombreux points parce qu’elles questionnent les formes et les instruments de la créativité, prennent position devant la tradition et visent la ... [more ▼]

Les images artistiques et scientifiques se ressemblent en de nombreux points parce qu’elles questionnent les formes et les instruments de la créativité, prennent position devant la tradition et visent la découverte. Cet ouvrage s’appuie sur la sémiotique et la philosophie pour dépasser les distinctions sommaires et affiner la comparaison. Il s’attache à quelques cas exemplaires d’images qui mettent en crise les distinctions commodes. Il leur offre un espace de transformation permettant de passer d’un monde à l’autre, ce qui permet d’apercevoir les modifications superficielles qu’implique le déplacement du sens mais aussi les obstacles qui les empêchent. <br />Une première partie envisage l’importation des modèles et pratiques scientifiques par l’art. Déplaçant le point de vue, la seconde aborde l’esthétisation et le devenir artistique de l’image scientifique. L’observation de ces passages permet d’interroger les conditions de l’interprétation des images, c’est-à-dire les instruments théoriques et épistémologiques qui autorisent l’interrogation mutuelle. <br />Avec les contributions de C. Allamel-Raffin, A. Beyaert-Geslin, J.F. Bordron, M. Colas-Blaise, B. Darras, M.G. Dondero, O. Le Guern, D. Daou et F. Wesemael, on découvre ainsi comment arts et sciences ne cessent de dialoguer au travers de leurs images, de s’interpeller mutuellement, d’interroger réciproquement leur rapport à la connaissance en réexaminant continument leurs différences. L’emprunt mutuel des modèles et procédures artistiques et scientifiques procède d’une démarche épistémique et introduit une possibilité de distanciation, une plasticité vis-à-vis du croire. Il permet d’interroger les paramètres d’évaluation de la découverte et de réexaminer le rapport à la connaissance de chacun des domaines. [less ▲]

Detailed reference viewed: 55 (16 ULg)
Full Text
Peer Reviewed
See detailImplementation of the ALERT algorithm, a new dispatcher-assisted telephone cardiopulmonary resuscitation protocol, in non-Advanced Medical Priority Dispatch System (AMPDS) Emergency Medical Services centres.
STIPULANTE, Samuel ULg; Tubes, Rebecca; Fassi, Mehdi El et al

in Resuscitation (2014), 85(2), 177-181

Objectives: Early bystander cardiopulmonary resuscitation (CPR) is a key factor in improving survival from out-of-hospital cardiac arrest (OHCA). The ALERT (Algorithme Liegeois d'Encadrement a la ... [more ▼]

Objectives: Early bystander cardiopulmonary resuscitation (CPR) is a key factor in improving survival from out-of-hospital cardiac arrest (OHCA). The ALERT (Algorithme Liegeois d'Encadrement a la Reanimation par Telephone) algorithm has the potential to help bystanders initiate CPR. This study evaluates the effectiveness of the implementation of this protocol in a non-Advanced Medical Priority Dispatch System area. Methods: We designed a before and after study based on a 3-month retrospective assessment of victims of OHCA in 2009, before the implementation of the ALERT protocol in Liege emergency medical communication centre (EMCC), and the prospective evaluation of the same 3 months in 2011, immediately after the implementation. Results: At the moment of the call, dispatchers were able to identify 233 OHCA in the first period and 235 in the second. Victims were predominantly male (59%, both periods), with mean ages of 64.1 and 63.9 years, respectively. In 2009, only 9.9% victims benefited from bystander CPR, this increased to 22.5% in 2011 (p<0.0002). The main reasons for protocol under-utilisation were: assistance not offered by the dispatcher (42,3%), caller physically remote from the victim (20.6%). Median time from call to first compression, defined here as no flow time, was 253sec in 2009 and 168sec in 2011 (NS). Ten victims were admitted to hospital after ROSC in 2009 and 13 in 2011 (p=0.09). Conclusion: From the beginning and despite its under-utilisation, the ALERT protocol significantly improved the number of patients in whom bystander CPR was attempted. [less ▲]

Detailed reference viewed: 39 (15 ULg)