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See detailEditorial : Allez au Red Star Line Museum à Anvers!
Drouguet, Noémie ULg

Article for general public (2016)

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See detailCore cross-linked micelles of polyphosphoester containing amphiphilic block copolymers as drug nanocarriers
Ergül, Zeynep ULg; Vanslambrouck, Stéphanie; Cajot, Sébastien et al

in RSC Advances (2016), 6(48), 42081-42088

Poly(ethylene oxide)-b-polyphosphoester amphiphilic block copolymers are known to self-assemble into polymer micelles when dissolved into water. This work aims at reporting on the improvement of the ... [more ▼]

Poly(ethylene oxide)-b-polyphosphoester amphiphilic block copolymers are known to self-assemble into polymer micelles when dissolved into water. This work aims at reporting on the improvement of the stability of the micelles at high dilution by crosslinking the hydrophobic polyphosphoester micellar core. Typically, an unsaturated alkene side-chain was introduced on the cyclic phosphate monomer according to a one-step reaction followed by its organocatalyzed polymerization initiated by a poly(ethylene oxide) macroinitiator. This strategy avoids the use of any organometallic compounds in order to facilitate the purification and meet the stringent requirements of biomedical applications. After self-assembly into water, the micelles were cross-linked by simple UV irradiation. These cross-linked micelles have then been loaded by doxorubicin to evaluate their potential as drug nanocarriers and monitor the impact of crosslinking on the release profile. [less ▲]

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See detailMechanical behaviour of tape springs used in the deployment of reflectors around a solar panel
Dewalque, Florence ULg; Collette, Jean-Paul; Bruls, Olivier ULg

in Acta Astronautica (2016), 123

In order to increase the production of power on small satellites, solar panels are commonly deployed and, in some cases, reflectors are added to improve the concentration factor on solar cells. In this ... [more ▼]

In order to increase the production of power on small satellites, solar panels are commonly deployed and, in some cases, reflectors are added to improve the concentration factor on solar cells. In this work, reflectors are deployed by the means of compliant mechanisms known as tape springs. Their attractive characteristics are, among others, their passive behaviour, their self-locking capacity, their elastic deformations and their robustness. However, their mechanical behaviour is highly nonlinear and requires thorough analyses in order to develop predictive numerical models. It is shown here through parametric studies that the nonlinear behaviour of a tape spring is mainly governed by its geometry. Thus, for each specific application, its dimensions can be determined in order to minimise two critical features: the maximum stress affecting the structure and the maximum motion amplitude during deployment. In this paper, an optimisation procedure is proposed to meet these requirements. [less ▲]

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See detailProduction, purification and characterization of a novel cold-active superoxide dismutase from the Antarctic strain Aspergillus glaucus 363
Abrashev, R.; Feller, Georges ULg; Kostadinova, N. et al

in Fungal Biology (2016), 120

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See detailLa valorisation du patrimoine scientifique, technique et industriel en Belgique francophone : un état des lieux et des enjeux
Peters, Arnaud ULg; Halleux, Robert ULg

in Ballé, Catherine; Cuenca, Catherine (Eds.) Le patrimoine scientifique et technique contemporain (2016)

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See detailHidden Markov Model-based population synthesis
Saadi, Ismaïl ULg; El Saeid Mustafa, Ahmed Mohamed ULg; Teller, Jacques ULg et al

in Transportation Research. Part B : Methodological (2016), 90

Micro-simulation travel demand and land use models require a synthetic population, which consists of a set of agents characterized by demographic and socio-economic attributes. Two main families of ... [more ▼]

Micro-simulation travel demand and land use models require a synthetic population, which consists of a set of agents characterized by demographic and socio-economic attributes. Two main families of population synthesis techniques can be distinguished: (a) fitting methods (iterative proportional fitting, updating) and (b) combinatorial optimization methods. During the last few years, a third outperforming family of population synthesis procedures has emerged, i.e., Markov process-based methods such as Monte Carlo Markov Chain (MCMC) simulations. In this paper, an extended Hidden Markov Model (HMM)-based approach is presented, which can serve as a better alternative than the existing methods. The approach is characterized by a great flexibility and efficiency in terms of data preparation and model training. The HMM is able to reproduce the structural configuration of a given population from an unlimited number of micro-samples and a marginal distribution. Only one marginal distribution of the considered population can be used as a boundary condition to “guide” the synthesis of the whole population. Model training and testing are performed using the Survey on the Workforce of 2013 and the Belgian National Household Travel Survey of 2010. Results indicate that the HMM method captures the complete heterogeneity of the micro-data contrary to standard fitting approaches. The method provides accurate results as it is able to reproduce the marginal distributions and their corresponding multivariate joint distributions with an acceptable error rate (i.e., SRSME=0.54 for 6 synthesized attributes). Furthermore, the HMM outperforms IPF for small sample sizes, even though the amount of input data is less than that for IPF. Finally, simulations show that the HMM can merge information provided by multiple data sources to allow good population estimates. [less ▲]

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See detailNollywood. L'industria video nigeriana e le sue diramazioni transnazionali
Jedlowski, Alessandro ULg

Book published by Liguori (2016)

Il volume ricostruisce la genesi e lo sviluppo dell’industria video nigeriana detta Nollywood, un sistema che produce 1000-1500 film ogni anno e li distribuisce direttamente in formato home-video. I video ... [more ▼]

Il volume ricostruisce la genesi e lo sviluppo dell’industria video nigeriana detta Nollywood, un sistema che produce 1000-1500 film ogni anno e li distribuisce direttamente in formato home-video. I video di Nollywood circolano in quasi tutta l’Africa sub-sahariana, nei Caraibi, in Nord America, in Canada e nella maggior parte dei paesi europei. Hanno dato vita a nuove forme di pan-africanismo, grazie alla combinazione tra il modo con cui sono prodotti e distribuiti e i valori estetici, culturali e sociali che essi veicolano. È un tipo di pan-africanismo ben diverso da quello promosso dai grandi portavoce della lotta anticoloniale, ma non per questo si dimostra meno efficace e influente. Il grande successo internazionale di Nollywood ha riaperto il dibattito su cosa significhi «essere africani oggi» e sulle trasformazioni sociali e culturali che hanno attraversato l’Africa negli ultimi anni. [less ▲]

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See detailPhage therapy against antimicrobial resistance, design of the first clinical study Phagoburn.
Jault, Patrick; Gabard, Jérôme; Leclerc, Thomas et al

in Critical Care (2016), 20(Suppl 2), 109

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See detailFurther insights into the metamorphosis process in a carapid fish
Parmentier, Eric ULg

in Journal of Zoology (2015)

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See detailLe couplage « Micro-crédit, Micro-assurance santé et Offre des soins » peut améliorer l’accessibilité aux soins de santé de qualité en milieu urbain africain : Résultats d’une expérience menée dans la zone de santé de Bandalungwa à Kinshasa, Congo.
Manzambi Kuwekita, Joseph ULg; Gosset, Christiane ULg; Guillaume, Michèle ULg et al

in Médecine et Santé Tropicales (2015), 25

Summary This study, based on a survey carried out in 2008, examines how coupling «microcredit, micro-insurance and health care» can improve access to quality care in the health zone of Bandalungwa, in ... [more ▼]

Summary This study, based on a survey carried out in 2008, examines how coupling «microcredit, micro-insurance and health care» can improve access to quality care in the health zone of Bandalungwa, in Kinshasa. The bivariate analysis shows a significant association between the increase in purchasing power and realization of benefit (p = 0, 001), achievement of benefit and savings (p = 0, 000) savings and insurance health and improved access to health care: according to the main results, 68.8 %t of borrowers reported an increase in their purchasing power which 81.8% making benefit. Those with savings were 24.7 times more likely to contribute to a health insurance scheme than those without; 71.9% of those who have regularly contributed to health insurance have improved their access to care. Coupling microcredit, health microinsurance and health care can improve access to quality health care at lower cost. This suggests the integration of health insurance in the primary health care system. [less ▲]

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See detailLe droit constitutionnel de la Principauté de Liège au 18e siècle
Behrendt, Christian ULg; Vandenbosch, Sofia ULg

in Revue Belge de Droit Constitutionnel [= RBDC] (2015), 2015

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See detailUn moment machiavélien dans la théorie. Sur Althusser
Oulc'hen, Hervé ULg

in Cahiers du GRM (2015), 8

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See detailCirculating microRNA-based screening tool for breast cancer
Freres, Pierre ULg; Wenric, Stéphane ULg; Boukerroucha, Meriem et al

in Oncotarget (2015)

Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. Here, their plasmatic levels were measured to be used as an alternative ... [more ▼]

Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. Here, their plasmatic levels were measured to be used as an alternative screening procedure to mammography for breast cancer diagnosis. A plasma miRNA profile was determined by RT-qPCR in a cohort of 378 women. A diagnostic model was designed based on the expression of 8 miRNAs measured first in a profiling cohort composed of 41 primary breast cancers and 45 controls, and further validated in diverse cohorts composed of 108 primary breast cancers, 88 controls, 35 breast cancers in remission, 31 metastatic breast cancers and 30 gynecologic tumors. A receiver operating characteristic curve derived from the 8-miRNA random forest based diagnostic tool exhibited an area under the curve of 0.81. The accuracy of the diagnostic tool remained unchanged considering age and tumor stage. The miRNA signature correctly identified patients with metastatic breast cancer. The use of the classification model on cohorts of patients with breast cancers in remission and with gynecologic cancers yielded prediction distributions similar to that of the control group. Using a multivariate supervised learning method and a set of 8 circulating miRNAs, we designed an accurate, minimally invasive screening tool for breast cancer. [less ▲]

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See detailIdentification d’indicateurs de la transition forestière en lien avec les impacts de la déforestation sur les socio-écosystèmes en Afrique centrale
Gillet, Pauline ULg; Vermeulen, Cédric ULg

Poster (2015, December 26)

La théorie de la transition forestière lie l’évolution du couvert forestier au temps (Mather, 1992). Dans la première phase, le couvert forestier est très dense. Il diminue ensuite avec l’augmentation de ... [more ▼]

La théorie de la transition forestière lie l’évolution du couvert forestier au temps (Mather, 1992). Dans la première phase, le couvert forestier est très dense. Il diminue ensuite avec l’augmentation de la densité de population qui pratique la défriche pour la production agricole et utilise le bois pour répondre aux besoins en énergie et en bois d’œuvre. Dans un troisième temps, l’économie se spécialise, l’agriculture s’intensifie et est pratiquée sur les terres les plus productives et le rôle de l’écosystème forestier dans l’économie diminue. L’abandon des terres les moins productives permet la recolonisation forestière visible sur la courbe de transition. La présente étude tente d’identifier et de proposer des indicateurs d’occupation spatiale permettant, sur base d’images de télédétection, de prévoir la position réelle d’un site sur la courbe de transition forestière. Ensuite, l’étude des socio-écosystèmes en lien avec la transition forestière permet de démontrer l’impact de la diminution du couvert forestier sur le fonctionnement des sociétés humaines. Nous nous sommes penchés sur différents aspects caractérisant les activités des populations locales dans trois sites d’étude situés sur un gradient de déforestation en Afrique centrale tels que la composition de repas et l’origine des aliments. On observe que la déforestation induit une diminution des composants issus des activités fortement liées à l’écosystème telles que la chasse, la pêche ou la collecte au profit de l’agriculture et de l’élevage. [less ▲]

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See detailAnticoherence of spin states with point-group symmetries
Baguette, Dorian ULg; Damanet, François ULg; Giraud, Olivier et al

in Physical Review A (2015), 92

We investigate multiqubit permutation-symmetric states with maximal entropy of entanglement. Such states can be viewed as particular spin states, namely anticoherent spin states. Using the Majorana ... [more ▼]

We investigate multiqubit permutation-symmetric states with maximal entropy of entanglement. Such states can be viewed as particular spin states, namely anticoherent spin states. Using the Majorana representation of spin states in terms of points on the unit sphere, we analyze the consequences of a point-group symmetry in their arrangement on the quantum properties of the corresponding state. We focus on the identification of anticoherent states (for which all reduced density matrices in the symmetric subspace are maximally mixed) associated with point-group-symmetric sets of points. We provide three different characterizations of anticoherence and establish a link between point symmetries, anticoherence, and classes of states equivalent through stochastic local operations with classical communication. We then investigate in detail the case of small numbers of qubits and construct infinite families of anticoherent states with point-group symmetry of their Majorana points, showing that anticoherent states do exist to arbitrary order. [less ▲]

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See detailReconstruction of the envelope of non-Gaussian structural responses with principal static wind loads
Blaise, Nicolas ULg; Canor, Thomas; Denoël, Vincent ULg

in Journal of Wind Engineering & Industrial Aerodynamics (2015), 149

In current practice, structural engineers commonly focus on the wind-resistant design by means of static wind loads. In case of non-Gaussianities, there is room for improvement to properly derive these ... [more ▼]

In current practice, structural engineers commonly focus on the wind-resistant design by means of static wind loads. In case of non-Gaussianities, there is room for improvement to properly derive these static loads. First, this paper extends in a non-Gaussian context the concept of the load-response correlation (LRC) method establishing equivalent static wind loads (ESWLs). This is done by a proper recourse to the new concept of conditional expected static wind load and a proposed bicubic model for the joint and conditional distribution functions. Second, this paper investigates the envelope reconstruction problem targeting the efficient reconstruction of the envelope values of a set of non-Gaussian structural responses by means of principal static wind loads (PSWLs). They have been introduced in a Gaussian context and are obtained by a singular value decomposition of ESWLs. This paper addresses the extension of PSWLs to non-Gaussian structural responses, as well. The developments apply to structures with a linear behavior and subjected to an aerodynamic pressure field exhibiting mildly to strongly non-Gaussian features. In this context, the well-known load-response correlation and conditional sampling methods are used for comparisons. This study is undertaken for quasi-static analysis of structures and is illustrated on a low-rise building. [less ▲]

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See detailarchiDART: Plant Root System Architecture Analysis Using DART and RSML Files
Delory, Benjamin ULg; Baudson, Caroline ULg; Brostaux, Yves ULg et al

Computer development (2015)

Analysis of complex plant root system architectures (RSA) using the output files created by Data Analysis of Root Tracings (DART), an open-access software dedicated to the study of plant root architecture ... [more ▼]

Analysis of complex plant root system architectures (RSA) using the output files created by Data Analysis of Root Tracings (DART), an open-access software dedicated to the study of plant root architecture and development across time series (Le Bot et al (2010) DART: a software to analyse root system architecture and development from captured images, Plant and Soil, DOI: 10.1007/s11104-009-0005-2), and RSA data encoded with the Root System Markup Language (RSML) (Lobet et al (2015) Root System Markup Language: toward a unified root architecture description language, Plant Physiology, DOI: 10.1104/pp.114.253625). More information can be found in Delory et al (2015) archiDART: an R package for the automated computation of plant root architectural traits, Plant and Soil, DOI: 10.1007/s11104-015-2673-4. [less ▲]

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See detailContribution to the study of african swine fever in the Democratic Republic of Congo: epidemiological and virological approaches
Mulumba Mfumu Kazadi, Léopold ULg

Doctoral thesis (2015)

Les résultats de cette thèse sont présentés sous la forme d’un ensemble cohérent de quatre études. 1. – Caractérisation moléculaire des souches du virus de la peste porcine africaine (PPA) impliquées dans ... [more ▼]

Les résultats de cette thèse sont présentés sous la forme d’un ensemble cohérent de quatre études. 1. – Caractérisation moléculaire des souches du virus de la peste porcine africaine (PPA) impliquées dans la persistance de l’infection en Afrique centrale (République Démocratique du Congo, RDC). Entre 1997 et 2000, sur 350 prélèvements de sang et organes provenant des porcs apparemment sains, 73 porcs (20,8%) avaient les anticorps dirigés contre la peste porcine africaine (PPA). Au cours de la même enquête, des organes prélevés sur les carcasses des porcs provenant d’une ferme familiale avec des mortalités constatées ont permis la détection de l’ADN du virus de la PPA. La caractérisation du virus a permis d’établir une similarité génétique avec des souches d’Afrique de l’Ouest, notamment du Nigeria et du Ghana. 2. – Estimation de la prévalence de la peste porcine africaine en République Démocratique du Congo et évaluation de la sensibilité et de la spécificité de trois tests ELISA en condition de terrain. Une étude a été menée sur 495 porcs domestiques apparemment en bonne santé de la RDC afin de déterminer le niveau d’exposition au virus de la PPA sur la base de 3 tests ELISA utilisant respectivement comme antigène la protéine VP72 soit sous forme brute (CP72) ou soit sous forme recombinante (rp72) et la protéine p30 recombinante (rp30). En outre, une PCR ciblant la région conservée du gène B646L codant pour la protéine de capside VP72 a été utilisée afin de déterminer l'exposition en fonction du stade de l'infection virus de la PPA. La prévalence apparente (PA) calculée avec les tests ELISA variait de 10% (48/482) avec la RP30 à 22,3% (79/354) avec la rp72. Basé sur des résultats positifs reproduits au moins par deux tests de diagnostic, la PA globale a été estimé à 17% (55/328). Parmi 495 animaux testés par PCR, l’ADN du virus de la PPA a été détecté chez 7 animaux (1,4%), dont 5 porcs séropositifs. En outre, en considérant le test ELISA CP72 comme référence, la sensibilité et la spécificité relatives des tests ELISA rp72 et rp30 ont été estimées sur un sous-ensemble de 328 porcs pour lesquels les résultats à tous les tests étaient disponibles. Le test ELISA rp72 avait une sensibilité relative de 93,5% (IC à 95%: 82,1 à 98,6) et une spécificité relative de 88,0% (IC à 95%: 83,6 à 91,5). Le test ELISA rp30 avait une sensibilité relative de 34,8% (IC à 95%: 21,3 à 50,2) et une spécificité relative de 93,7% (IC à 95%: 89,7 à 95,9). La combinaison globale de la PCR et des trois tests ELISA a révélé que 62% des cas positifs avaient au moins un de leur résultat confirmé par un autre test. Le test ELISA rp72 peut être recommandé dans le dépistage à grande échelle de la maladie dans les zones endémiques de PPA en Afrique comme une alternative au test ELISA de CP72. En outre, le test ELISA de rp30 peut être recommandé pour la confirmation à tout stade de l'infection, y compris dans les plus précoces en parallèle avec la PCR. 3 – La caractérisation génétique des isolats du virus de la PPA impliquées dans les foyers en République Démocratique du Congo, entre 2005 et 2012, révèle une co-circulation de trois Génotypes : I, IX et XIV et 16 variants du virus. L’étude a portée sur 62 pièces anatomiques de rates, ganglions hépato-gastriques, reins, cœurs, poumons, foies et estomacs provenant des 57 carcasses des porcs dont 54 provenant de foyers et 3 provenant des points d’abattage des marchés. L’ensemble représente 25 foyers au total. Ces foyers concernent 5 Provinces de la RDC, dont notamment l’Equateur, le Bas-Congo, le Katanga et Kinshasa. L’étude a révélé la co-circulation de 3 génotypes (I, IX et XIV) et 16 variants du virus. 4 - Immunisation des porcs des races Africaines avec le virus OURT88/3 du Génotype I induit une protection contre l’infection avec deux souches virulentes du Génotype I. La souche atténuée OURT88/3 du virus de la PPA, de genotype I, a déjà démontré son pouvoir protecteur chez les porcs domestiques de races européennes envers les isolats virulents du virus de la PPA. Pour déterminer si les réponses immunitaires protectrices pourraient également être induites chez des porcs de races indigènes de de la région Kinshassa en République démocratique du Congo, nous avons immunisé un groupe de 8 porcs avec la souche atténuée OURT88/3 et infecté les porcs 21 jours plus tard avec la souche virulente OURT88/1 du même génotype. Parmi les 8 porcs, 4 ont été protégés contre l’infection. Trois des 8 porcs sont morts du virus de la PPA et un 4ième est mort de cause inconnue. Les 4 porcs restants ont survécu à une seconde infection avec une souche virulente RDC 085/10 du virus de la PPA, de même génotype. Deux groupes contrôles de porcs non immunisés ont été infectés par la souche OURT88/1 ou la souche RDC 085/10 et ont développé des signes cliniques aigus de la PPA. Ils avaient des niveaux élevés de génome viral dans le sang. [less ▲]

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See detailSkin ultrastructural similarities between fibromyalgia and Ehlers-Danlos syndrome hypermobility type
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg

in Journal of osteoarthritis (2015), 1(1),

Fibromyalgia (FM) and hypermobility type Ehlers-Danlos syndrome (EDSH) share a series of common clinical signs. A clinical distinction between both diseases is occasionally difficult to be established ... [more ▼]

Fibromyalgia (FM) and hypermobility type Ehlers-Danlos syndrome (EDSH) share a series of common clinical signs. A clinical distinction between both diseases is occasionally difficult to be established. The physical changes observed in the mechanical properties of skin and joints do not distinctly distinguish these disorders. In addition, similar ultrastructural dermal changes are observed in both EDSH and some FM cases. The molecular alterations remain largely undisclosed in both diseases. As a result, EDSH remains undiagnosed in some FM patients. This condition deteriorates quality of life and possibly leads to prominent health problems. [less ▲]

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