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See detailAnalysis of the interactions of fatty acyds hydroperoxides with biomimetic membranes by complementary biophysical approaches
Deboever, Estelle ULg; Nasir, Mehmet Nail ULg; Deleu, Magali ULg et al

Poster (2016, November 16)

In the actual context, biopesticides have emerged as a main alternative to conventional agriculture1. Hence, elicitors are metabolites naturally produced by microorganisms, pathogenic or not, and plants ... [more ▼]

In the actual context, biopesticides have emerged as a main alternative to conventional agriculture1. Hence, elicitors are metabolites naturally produced by microorganisms, pathogenic or not, and plants which are able to induce the natural resistance of plants. Also, they have proved to be excellent candidates for biological control. In this context, the lipoxygenase pathway leads to the formation of fatty acid degradation products, called oxylipins, which appear to be crucial agents in plant defence mechanisms2,3. Moreover, with their broad spectrum of action and their possible inducibility, oxylipins appear to be promising candidates for their use as elicitors4. This work focuses on two hydroperoxy-derived oxylipins, the 13(S)-hydroperoxy-octadecadienoic acid (13-HPOD) and the 13(S)-hydroperoxy-octadecatrienoic acid (13-HPOT). The study of the interaction of such compounds with representative plant plasma membrane lipids is essential to understand plant resistance mechanisms. Several in silico and experimental techniques of biophysics showed that acyl-hydroperoxides have significant adsorption capacity and a strong affinity for model membranes. They may also penetrate biological membrane but no permeabilisation effect was observed in this work. Slight conformational differences seem to have a significant impact on their ability to interact with plant plasma membranes. Based on these results, further investigation of the interactions of fatty acids hydroperoxides, even more on the 9-forms, with plant plasma membranes and eventually in the presence of phytopathogenic species, would allow a better understanding of the innate immunity and, on the longer term, could lead to the development of new elicitors with biological mechanisms potentially independent of membrane protein receptors. [less ▲]

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See detailPolyphenol content and antioxidant capacity in various commercial juices
Matute Matute, Alexis Fernando ULg; Tabart, Jessica; CHERAMY-BIEN, Jean-Paul ULg et al

Poster (2016, November 16)

Antioxidants are enzymes, non-enzymatic proteins, minerals micronutrients, vitamins, phenolic compounds, pigments and others. Polyphenols have the ability to reduce or prevent damage caused by free ... [more ▼]

Antioxidants are enzymes, non-enzymatic proteins, minerals micronutrients, vitamins, phenolic compounds, pigments and others. Polyphenols have the ability to reduce or prevent damage caused by free radicals promoting positive effects on human health due to their antioxidant capacity. In this study we evaluated the content of polyphenols from several commercial biological (n = 6) and conventional juices (n = 6 ) (orange, blackcurrant, apple, grapes, tomato, carrot, pomegranate, lemon, grapefruit juices) and we determined the antioxidant effect by inhibition of the superoxide anion production measured by chemiluminescence technology. Conventional juices (orange, apple, tomato, pomegranate, lemon, grapefruit juices) showed more total polyphenolics (+ 32%), more flavan-3-ols (+ 67%) and more flavonols (+ 42%) than the same biological juices. The presence of anthocyanins was reported in juices made with blackcurrant, pomegranate and grapes only, with values above 50 µg/mL, regardless of their nature. Surprisingly, chemiluminescence results showed an inhibition in superoxide anion production by 51% for biological juices vs 23% in conventional ones. The correlation between total polyphenol content and antioxidant capacity of all the juices was r = 0.83 (r2 = 0.7). The fact that there is less polyphenols and higher antioxidant activity in bio juices could be related to the concentration and the type of polyphenol present. [less ▲]

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See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULg; Centonze, Prescilia ULg; Comblain, Fanny ULg et al

Poster (2016, November 16)

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histological lesions with the mechanical properties of cartilage. [less ▲]

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See detailZinc, iron and manganese interaction within the frd3 Arabidopsis mutant
Scheepers, Maxime ULg; Spielmann, Julien ULg; Goormaghtigh, Erik et al

Poster (2016, November 16)

Zinc and iron are two essential micronutrients for plants. The homeostasis networks of the two metals are intertwined. Arabidopsis halleri is a zinc- and cadmium-tolerant and zinc-hyperaccumulating ... [more ▼]

Zinc and iron are two essential micronutrients for plants. The homeostasis networks of the two metals are intertwined. Arabidopsis halleri is a zinc- and cadmium-tolerant and zinc-hyperaccumulating species, which also present adaptation of its iron homeostasis(1,4). Transcriptomic studies identified genes which are constitu-tively over-expressed in Arabidopsis halleri compared to Arabidopsis thaliana and which may have a role in metal tolerance or accumulation(2-4). Among them, a candidate gene encodes the FRD3 (FERRIC REDUCTASE DEFECTIVE 3) protein, a member of the MATE family of membrane transporters. FRD3 is a citrate transporter involved in iron homeostasis(5-7) and plays a role in zinc tolerance in A. thaliana(8). The FRD3 gene displays a complex regulation. In A. thaliana, alternative transcript initiation for FRD3 determines two transcripts, which dif-fer in their 5'UTRs and have differential translation efficiency. The two transcripts are selectively regulated under stress conditions: iron and zinc depletion, zinc excess or cadmium presence(9). In A. halleri, a single highly ex-pressed FRD3 transcript with high translation efficiency is present(9). [less ▲]

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See detailComment former à l'argumentation?
Scheepers, Caroline ULg; Delneste, Stéphanie

Conference (2016, November 16)

Confronté à des questions qui touchent à l'éthique, quelle conduite argumentative va mobiliser un petit groupe d'intervenants pour débattre des questions posées? Plus concrètement, quel sera le degré d ... [more ▼]

Confronté à des questions qui touchent à l'éthique, quelle conduite argumentative va mobiliser un petit groupe d'intervenants pour débattre des questions posées? Plus concrètement, quel sera le degré d'argumentativité du discours? Quelle est la visée des échanges : convaincre ou persuader? Quels types d'arguments seront convoqués? Sur quelles valeurs se fonderont-ils? Quels phénomènes de contre-argumentation émergeront? L'atelier, pratique, consiste à mettre en situation les participants (profs de philo au primaire, au secondaire ou au supérieur) de débattre ou d'analyser un débat. [less ▲]

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See detailErasurism, Peritext, Hypertext & Infratext
Delville, Michel ULg

Conference (2016, November 16)

Detailed reference viewed: 14 (1 ULg)
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See detailDevelopment of a new method for arabidopsides extraction and purification
Genva, Manon ULg; Andersson, Mats X; Nasir, Mehmet Nail ULg et al

Poster (2016, November 16)

In the present work, a new method for arabidopsides extraction and purification was developed.

Detailed reference viewed: 37 (9 ULg)
See detailHydrocracking and ionic liquids pretreatments effects on aldehydes extraction and lignin modification of Arabidopsis and Sorghum
Jacquet, Nicolas ULg; Richel, Aurore ULg

Scientific conference (2016, November 16)

Study shown the effect of hydrocracking and ionic liquids pretreatments on aldehydes extraction and physico-chemical properties modification of model ligninfrom Arabidopsis and Sorghum. Result of the ... [more ▼]

Study shown the effect of hydrocracking and ionic liquids pretreatments on aldehydes extraction and physico-chemical properties modification of model ligninfrom Arabidopsis and Sorghum. Result of the study show various effect of the pretreatment on the molecular weight of lignin and make links between pretratment applied and chemical links between lignin monomers. [less ▲]

Detailed reference viewed: 30 (1 ULg)
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See detailSavant éclairé ou génie de l’ombre ? Les figures croisées de Tesla et Edison dans la culture populaire et médiatique
Stienon, Valérie ULg

Conference (2016, November 16)

L'épisode de la "guerre des courants électriques" survenue aux États-Unis dans les années 1880-1890 a donné lieu à de nombreuses représentations qui posent les inventeurs Thomas Edison et Nikola Tesla ... [more ▼]

L'épisode de la "guerre des courants électriques" survenue aux États-Unis dans les années 1880-1890 a donné lieu à de nombreuses représentations qui posent les inventeurs Thomas Edison et Nikola Tesla comme les protagonistes d’une guerre dramatisée autour de la question de l’électricité, avec ses possibles, ses infrastructures et son pouvoir économique, occasion de rejouer l’opposition des deux légendes, merveilleuse et noire, de l’électricité. Tous les matériaux sont réunis pour forger la légende. Une polémique à l’impact social important, qui questionne les rôles du savant, la valeur de la vérité scientifique, les considérations commerciales et la part d’ésotérisme liée à une nouvelle énergie touchant à l’invisible. Une proximité des récits scientifiques, médiatiques et littéraires, à propos de ces deux hommes liés à la notoriété et à l’image publique. Un grand potentiel visuel, comme en attestent les démonstrations spectaculaires (électrocutions d'animaux, expérimentations aux chutes du Niagara) et les mises en scène photographiques. À partir du binôme structurel que forment Edison et Tesla dans les représentations culturelles et médiatiques, la communication interroge deux sous-genres spécifiques, les édisonnades et le teslapunk, en analysant leur contexte d'émergence, leurs horizons d'attente et leurs interactions. [less ▲]

Detailed reference viewed: 37 (1 ULg)
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See detailHot-Melt Extrusion as a Continuous Manufacturing Process to Form Ternary Cyclodextrin Inclusion Complexes
Thiry, Justine ULg; Krier, Fabrice; Ratwatte, Shenelka et al

Poster (2016, November 16)

Detailed reference viewed: 15 (1 ULg)
See detailDifferent and synergistic effect of 5-Azacytidine and Rapamycin on ex vivo expansion of natural human T Regulatory cells
Conteduca, Giuseppina ULg

Poster (2016, November 16)

Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are ... [more ▼]

Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are immunosuppressive drugs that promote selectively the expansion of CD4+CD25highFoxp3+ regulatory T cells. We investigated whether 5-azaC and RAPA could be used together to promote the ex vivo expansion of Tregs purified from adult human peripheral blood. : We found that 5-azaC helped maintain FOXP3 expression during the expansion process probably by promoting the conversion of T conventional (Tconv) in Treg, instead Rapa induces selectively apoptosis in Tconv cells and expansion in Treg. Addition of 5-azaC to RAPA treated cultures improved gene expression of FOXP3, CD25, STAT5 and TGF-B resulted in enhanced Treg expansion and suppressive activity. Also Rapa and 5-AzaC combination sustain Bcl-2 protein expression in Treg conferring resistance to apoptosis process. 5-azaC may have utility in ex vivo expansion of human Tregs, not as a single agent, but in combination with RAPA. These data may considerably accelerate the development of immunotherapeutic approaches for the treatment of autoimmune disease or posttransplant alloreactions by the adoptive transfer of nTreg cells. [less ▲]

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See detailBelgian political situation
Verjans, Pierre ULg

Conference given outside the academic context (2016)

Belgian trends show that centrifugal move from the North of the country can lead to a separation or to a new form of federalism/confederalism.

Detailed reference viewed: 11 (1 ULg)
See detailLe Kimbanguisme et le prophétisme kongo : la tradition messianique dans la religion kongo / Kimbanguism and Kongo Prophetism : Messianic Tradition in Kongo Religion
Melice, Anne ULg; Sarró, Ramon

in Du Jourdain au Congo – Art et christianisme en Afrique centrale (2016)

Detailed reference viewed: 65 (2 ULg)
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See detailIncreased Risk of Group B Streptococcus Invasive Infection in HIV-Exposed but Uninfected Infants: A Review of the Evidence and Possible Mechanisms.
DAUBY, Nicolas; CHAMEKH, Mustapha; MELIN, Pierrette ULg et al

in Frontiers in Immunology (2016), 7

Group B Streptococcus (GBS) is a major cause of neonatal sepsis and mortality worldwide. Studies from both developed and developing countries have shown that HIV-exposed but uninfected (HEU) infants are ... [more ▼]

Group B Streptococcus (GBS) is a major cause of neonatal sepsis and mortality worldwide. Studies from both developed and developing countries have shown that HIV-exposed but uninfected (HEU) infants are at increased risk of infectious morbidity, as compared to HIV-unexposed uninfected infants (HUU). A higher susceptibility to GBS infections has been reported in HEU infants, particularly late-onset diseases and more severe manifestations of GBS diseases. We review here the possible explanations for increased susceptibility to GBS infection. Maternal GBS colonization during pregnancy is a major risk factor for early-onset GBS invasive disease, but colonization rates are not higher in HIV-infected compared to HIV-uninfected pregnant women, while selective colonization with more virulent strains in HIV-infected women is suggested in some studies. Lower serotype-speci c GBS maternal antibody transfer and quantitative and qualitative defects of innate immune responses in HEU infants may play a role in the increased risk of GBS invasive disease. The impact of maternal antiretroviral treatment and its consequences on immune activation in HEU newborns are important to study. Maternal immunization presents a promising intervention to reduce GBS burden in the growing HEU population. [less ▲]

Detailed reference viewed: 21 (2 ULg)
See detailInterpellations impossibles. Question à Judith Butler
Borotto, Jessica ULg

Conference (2016, November 16)

Detailed reference viewed: 19 (1 ULg)
See detailLes débuts du Gravettien dans le Nord-Ouest de l’Europe (28.000-26.000 BP)
Touzé, Olivier ULg

Scientific conference (2016, November 16)

Detailed reference viewed: 12 (0 ULg)