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See detailComputing k-binomial equivalence and avoiding binomial repetitions
Rigo, Michel ULg

Conference (2015, October 28)

In this talk, I will first recall basic results on binomial coefficients of words, then review the connections and differences with Parikh matrices. As a generalization of abelian equivalence, two words u ... [more ▼]

In this talk, I will first recall basic results on binomial coefficients of words, then review the connections and differences with Parikh matrices. As a generalization of abelian equivalence, two words u and v are k-binomially equivalent if every word of length at most k appears as a subword of u exactly as many times as it appears as a subword of v. So a k-binomial square is a word uv where u and v are k-binomially equivalent. We will discuss avoidance of squares and cubes in infinite words (this is a joint word with M. Rao). Finally, I will consider the question of deciding whether or not two finite words are k-binomially equivalent. This problem has recently been shown to be decidable in polynomial time by Freydenberger, Gawrychowski et al. [less ▲]

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See detailMarks & Spencer: A Landmark Decision?
Richelle, Isabelle ULg

in Haslehner, Werner; Kofler, Georg; Rust, Alexander (Eds.) Landmark Decisions of the ECJ in Direct Taxation (2015)

Every professional dealing with taxation in the European Union will greatly appreciate this extraordinarily useful book. Based on a high-level conference held at the University of Luxembourg in 2014, the ... [more ▼]

Every professional dealing with taxation in the European Union will greatly appreciate this extraordinarily useful book. Based on a high-level conference held at the University of Luxembourg in 2014, the book presents detailed expert summaries and analyses of landmark ECJ decisions in direct taxation, each case a starting point for the development of a specific doctrine. The depth of the analysis, as each author charts a way through the nuances of the Court’s arguments, allows the reader to gain an unparalleled understanding of changes in the relevant subsequent jurisprudence. [less ▲]

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See detailMort Cellulaire et Développement chez Streptomyces coelicolor
Tenconi, Elodie ULg

Doctoral thesis (2015)

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See detailWhat is Quaternary prevention ?
Jamoulle, Marc ULg

Conference (2015, October 27)

Principle of quaternary prevention

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See detailPourquoi l'écriture importe
Pieron, Julien ULg

Conference (2015, October 27)

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See detailLes exigences de la « terrestrialité »: une épreuve pour l’enquête
Thoreau, François ULg

Conference (2015, October 27)

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See detailA prospective 4 year study of the objective and subjective outcomes of 15 patients after dynamic facial reanimation surgery.
ANDREWS, Peter J; RANDHAWA, Premjit S; JOSEPH, Jonathan et al

in Clinical Otolaryngology (2015)

Facial nerve palsy is a debilitating and life changing event which significantly affects quality of life. This prospective study evaluates outcomes in 15 patients undergoing dynamic facial reanimation ... [more ▼]

Facial nerve palsy is a debilitating and life changing event which significantly affects quality of life. This prospective study evaluates outcomes in 15 patients undergoing dynamic facial reanimation surgery using a modification of the minimally invasive temporalis tendon transposition technique (MIT3) coupled with either static reanimation techniques or synergistic inter-positional/facial-hypoglossal nerve reconstruction techniques. All patients demonstrated significant improvement both objectively and subjectively as measured by the SMILE system and FaCE scale respectively. The MIT3 technique can be used successfully for dynamic reanimation and allows for other techniques to be simultaneously tailored around it. It provides improved functional and quality of life outcomes in patients and affords low morbidity. [less ▲]

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See detailAspects malacologiques du cycle de Fasciola hepatica en Belgique et en Equateur
Caron, Yannick ULg

Doctoral thesis (2015)

Fasciolosis is a zoonotic disease of ruminants and other herbivorous due to two parasite species of the genus Fasciola. If Fasciola gigantica is a tropical species, F. hepatica has a much wider geographic ... [more ▼]

Fasciolosis is a zoonotic disease of ruminants and other herbivorous due to two parasite species of the genus Fasciola. If Fasciola gigantica is a tropical species, F. hepatica has a much wider geographic distribution. Fasciola hepatica is responsible for important economic losses such as a marked reduction of milk yield and liver condemnation at the slaughterhouse. The life cycle of this platyhelminth involves an intermediate host, a gastropod mollusc belonging to the Lymnaeidae family. In temperate Europe, Galba truncatula acts as the main intermediate host of F. hepatica. A wide network project called MANSCAPE allowed the implementation of a sampling campaign conducted in more than 125 ponds throughout Belgium which revealed that other lymnaeid snails (belonging to the genus Radix) could act as secondary or alternative intermediate hosts. Some experimental infections of snails and rats permited to study the host-parasite relationships in some of these species (Radix balthica, R. labiata). Sibling species very similar to « R. peregra » seem to contain several potential candidates. Several techniques are available to detect the parasite in the snail: they are based either on microscopy or on molecular biology. A very sensitive (100 pg parasite DNA still detectable) and specific technique based on molecular biology (Multiplex PCR) was developed. This technique was used qualitatively and quantitatively to determine the intermediate host species involved in the life cycle of the liver fluke in Belgium. This study was performed in the frame of the PONDSCAPE project and prevalences of 1.31% (30/2747) and 0.16% (7/4629) were recorded for G. truncatula and R. balthica respectively. This technique was then used in Ecuador to bring some information on the intermediate host species involved in the life cycle of F. hepatica. Galba schirazensis, an invasive species in South America, was identified as a lymnaeid that could harbour a part of the life cycle of the parasite as 8.15% (86/1055) of the collected snail contained parasite DNA and 2.46% (26/1055) living larvae. These studies showed that R. balthica could have an impact on the epidemiology of F. hepatica in Belgium and that the role of G. schirazensis in Ecuador needs to be clarified. This will be discussed in this work and specially in term of co-evoultion and adpatation way. [less ▲]

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See detailReceiver operating characteristic (ROC) curves and their use in psychometric simulation studies
Magis, David ULg

Scientific conference (2015, October 27)

Simulation studies are commonly used in psychometric research to compare existing methods or to highlight the outperformance of a newly developed approach with respect to standard techniques. In several ... [more ▼]

Simulation studies are commonly used in psychometric research to compare existing methods or to highlight the outperformance of a newly developed approach with respect to standard techniques. In several specific situations, the output of performance evaluations can be summarized by pairs of statistics such as false alarm and hit rates (or Type I error and power). Adequate analysis of these rates, however, is often subject to discussion. The purpose of this ongoing work (jointly with Francis Tuerlinckx) is to advocate the usefulness of receiver operating characteristic (ROC) curves to analyze the output of simulation studies in terms of pairs of summary statistics. Two particular psychometric applications will be considered and illustrated: differential item functioning (DIF) and person fit identification. By means of simple examples, ROC curves will be shown to be efficient in capturing more output than standard analyses, thus allowing for a more refined and precise discussion of the study results. Limitations and other extensions will also be outlined. [less ▲]

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See detailAxe 3 : Démarche qualité
Adam, Stéphane; Missotten, Pierre ULg

Conference given outside the academic context (2015)

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See detailEnquête, SF, politique. Comment nous avons croisé Haraway
Pieron, Julien ULg

Conference (2015, October 26)

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See detailProduction of alumina foundry moulds by additive manufacturing for low and high melting points alloys prototypes
Bister, Geoffroy; Deschuyteneer, Dorian; Hautcoeur, Dominique et al

Poster (2015, October 26)

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See detailComment réagir face aux manifestations de dérive radicale chez un jeune ?
Garcet, Serge ULg

Article for general public (2015)

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See detailHPV infection, squamo-columnar junction and potential cancer prevention
Herfs, Michael ULg

Conference (2015, October 26)

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See detailEvaluation isocinétique de la fatigabilité musculaire du genou: qu'en est-il de la reproductibilité intra-dynamomètre et de la compatibilité inter-dynamomètre?
Paulus, Julien ULg; Krecke, Roland; Bosquet, Laurent et al

Poster (2015, October 26)

Abstract Certains aspects de l'isocinétisme, bien que considéré comme un gold standard de l'évaluation musculaire [1], restent à explorer: entre autre la reproductibilité intra-dynamomètre des index de ... [more ▼]

Abstract Certains aspects de l'isocinétisme, bien que considéré comme un gold standard de l'évaluation musculaire [1], restent à explorer: entre autre la reproductibilité intra-dynamomètre des index de fatigue (quotient des n dernières répétitions par les x premières par exemple) et des paramètres mesurés lors d'une épreuve de fatigabilité musculaire pour le genou mais également la compatibilité inter-dynamomètre de cette même épreuve de résistance à la fatigue. Après étude via à un test-retest, la reproductibilité des index de fatigue semble très insuffisante pour une utilisation clinique ou scientifique, au contraire des paramètres mesurés. De plus, après exploration via la réalisation du protocole sur trois modèles différents, il apparait que la reproductibilité insuffisante des fléchisseurs du genou ne permettrait pas de comparer les résultats obtenus sur différents dynamomètres. Introduction Les tests isocinétiques contribuent largement à l'évaluation de la performance musculaire et en sont considérés comme un gold standard [1]. Les tests de fatigabilité peuvent s'avérer complémentaires des épreuves courtes de force notamment pour évaluer un athlète sollicitant particulièrement la filière anaérobie lactique ou dans des contextes pathologiques spécifiques [2]. Bien que Bosquet et al. [3] aient démontré la reproductibilité d'un protocole de fatigabilité pour le genou, 30 flexions-extensions maximales à 180°.s-1 avec une amplitude de 100°, à notre connaissance, aucune étude, ayant pour objectif d'être exhaustive dans son analyse, n'a été menée sur la reproductibilité des paramètres mesurés (meilleure répétition, cumuls total et partiels) et index de fatigue (quotient des n dernières répétitions par les x premières, du cumul des répétitions par la meilleure,…) bien qu'ils soient proposés directement par les dynamomètres et/ou utilisés en clinique et dans la littérature lors de l'étude de la fatigabilité du genou [4]. Sont-ils suffisamment reproductibles pour que leur utilisation soit scientifiquement validée? La compatibilité des résultats d'une épreuve de fatigabilité du genou entre différents dynamomètres isocinétiques n'a également, à notre connaissance, pas été évaluée récemment, qui plus est sur plus de deux dynamomètres de marques différentes [5]. Est-il envisageable de comparer les résultats obtenus sur des dynamomètres de marques différentes et de généraliser les normes? Méthodes Pour tenter d'apporter un élément de réponse à la première question, dix-huit hommes sains, modérément actifs, ont réalisé trente extensions-flexions maximales du genou à trois occasions sur un Biodex System 3 Pro, en observant sept à dix jours de repos entre chaque session. Afin de compiler onze paramètres mesurés et de construire quarante-quatre index, le moment de force maximum (MFM) et le travail maximal (Wmax) de chaque répétition ont été enregistrés. La reproductibilité de chaque paramètre et index a été évaluée via leur ICC (2,1), SEM et MD respectifs. Pour évaluer la compatibilité inter-dynamomètre du Biodex System 3 Pro, du Con-Trex MJ PM-2 et du Cybex Humac CSMI, vingt-et-un sujets sains, modérément actifs, ont réalisé trente extensions-flexions maximales du genou à trois occasions, en observant six à dix jours de repos entre chaque session. Le MFM et le Wmax de chaque répétition ont été enregistrés. La compatibilité inter-dynamomètre deux-à-deux a été évaluée à l'aide des ICC (3,1), SEM et MD des paramètres mesurés.   Résultats En ce qui concerne la reproductibilité intra-dynamomètre, les valeurs d'ICC des paramètres mesurés pour les extenseurs du genou sont quasi-systématiquement supérieures à 0.8 tandis que celles pour les fléchisseurs oscillent entre 0.7 et 0.8. Les index de fatigue présentent quant à eux des ICC inférieurs à 0.7 et 0.5 respectivement pour les extenseurs et fléchisseurs. Les valeurs d'ICC ne diffèrent guère entre le MFM et le Wmax (que ce soit pour les extenseurs ou les fléchisseurs ou pour les paramètres mesurés et les index de fatigue). Pour le volet compatibilité inter-dynamomètre, les ICC des paramètres mesurés lors de l'épreuve de fatigabilité musculaire des extenseurs du genou sont très majoritairement supérieurs à 0.8, quelle que soit la paire de dynamomètres considérée. A contrario, les ICC de ces mêmes paramètres mesurés sont presque tous inférieurs à 0.7 pour les fléchisseurs. Les valeurs d'ICC ne diffèrent guère entre le MFM et le Wmax (que ce soit pour les extenseurs ou les fléchisseurs). Logiquement, la compatibilité inter-dynamométrique des index de fatigue n'a pas été étudiée puisque leur reproductibilité intra-dynamomètre a été démontrée comme insuffisante dans la première partie de notre étude. Discussion Considérant qu'un ICC supérieur à 0.8 soit acceptable pour une utilisation clinique [6], nous pouvons conclure que, compte tenu des valeurs obtenues sur notre population, aucun index de fatigue, bien que séduisant compte tenu de leur capacité théorique à caractériser la décroissance de la performance lors d'une épreuve de fatigabilité, ne semble présenter une reproductibilité intra-dynamométrique suffisante pour une utilisation clinique ou de recherche. Seuls les paramètres mesurés tels que la meilleure répétition, les cumuls total ou partiels apparaissent utilisables, en clinique et dans un contexte de recherche, en raison d'une reproductibilité intra-dynamométrique qui peut être qualifiée de (très) haute voire excellente [7, 8]. Des index de fatigue sont donc fréquemment utilisés alors que leur reproductibilité semble très largement insuffisante. La reproductibilité inter-dynamomètre des paramètres mesurés du protocole de fatigue défini par Bosquet et al. [3] permet leur utilisation clinique pour les extenseurs du genou mais est très insuffisante pour les fléchisseurs. Il apparaît donc nécessaire de réaliser les tests à chaque reprise sur le même dynamomètre dans le cadre de suivis longitudinaux ou des comparaisons transversales impliquant les fléchisseurs du genou. Ce manque de compatibilité inter-dynamomètre implique également que les normes soient spécifiques à chaque modèle de dynamomètre isocinétique. Conclusion Nos résultats indiquent que les index de fatigue ne peuvent être utilisés que ce soit dans un contexte clinique ou de recherche pour l'évaluation isocinétique du genou. Seuls les paramètres mesurés sont suffisamment reproductibles pour être employés. Le manque de compatibilité inter-dynamomètre pour les fléchisseurs du genou impliquent d'utiliser le même dynamomètre isocinétique lors de suivis longitudinaux ou de comparaisons transversales. [less ▲]

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See detailDynamics of Internalization and Recycling of the pro-Metastatic Membrane Type 4-Matrix Metalloproteinase (MT4-MMP) in Breast Cancer cells
Truong, Alice ULg; Yip, Cassandre ULg; PAYE, Alexandra ULg et al

Poster (2015, October 26)

MT4-MMP (MMP17) is a glycosyl-phosphatidyl inositol-anchored membrane-type matrix metalloproteinase expressed at the cell surface of human breast cancer cells. In triple negative breast cancer, MT4-MMP ... [more ▼]

MT4-MMP (MMP17) is a glycosyl-phosphatidyl inositol-anchored membrane-type matrix metalloproteinase expressed at the cell surface of human breast cancer cells. In triple negative breast cancer, MT4-MMP promotes primary tumor growth and lung metastases. Recently, we demonstrated that EGFR activation and signaling are enhanced by MT4-MMP in a non-proteolytic dependent manner. While trafficking and internalization of EGFR was extensively investigated, little is known about MT4-MMP. Here, we investigated the dimerization, internalization and recycling dynamics of MT4-MMP and its mutated inactive form MT4-MMP-E249A. We demonstrate that MT4-MMP forms dimers and oligomers at the cell surface, a process that was not inhibited neither by broad-spectrum MMP inhibitors (GM6001 and BB94) nor TIMP-2. MT4-MMP is internalized in early endosomes from 10 minutes to 60 minutes. Once internalized, some amount of MT4-MMP is auto-degraded, whereas its inert form E249A was found intact. Large part of the internalized enzyme was recycled intact at the cell surface. By exploring its endocytosis, we found that MT4-MMP is internalized by the CLIC/GEEC pathway, a mechanism that differs from other MT-MMP members. Overall, we provided a new mechanistic insight on the regulatory mechanisms of MT4-MMP in human breast cancer cells. We also, highlighted unique features of MT4-MMP among membrane-associated MMPs, which may be useful for the design of novel therapeutic strategies for metastatic breast cancer. [less ▲]

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See detailThe thickness of words : politique et biologie chez Donna Haraway
Caeymaex, Florence ULg

Conference (2015, October 26)

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See detailInnovative semiconducting oxide materials reducing the energy footprint of buildings
Dewalque, Jennifer ULg; Maho, Anthony ULg; Spronck, Gilles ULg et al

Conference (2015, October 26)

In the current energy context, many efforts are devoted to the reduction of the energy footprint of buildings. To meet this challenge, the LCIS-GREENMAT laboratory developes a front edge research in the ... [more ▼]

In the current energy context, many efforts are devoted to the reduction of the energy footprint of buildings. To meet this challenge, the LCIS-GREENMAT laboratory developes a front edge research in the field of advanced materials associated to energy and environment, including structured materials for dye-sensitized solar cells (DSSCs) and electrochromic coatings. DSSCs have been reported by O’Regan and Grätzel in the early nineties as a very promising alternative to conventional photovoltaic silicon devices. Main benefits of these cells are their low cost as well as their mild manufacturing process. In most of the specific literature, DSSCs are made of TiO2 films prepared by doctor-blade or screen-printing of anatase nanoparticles paste. However, due to the random organization of the nanoparticles, pore accessibility by the dye and electrolyte could be incomplete. Moreover, some anatase crystallites could suffer from a lack of connectivity, leading to electron transfer issues. The strategy adopted by our group to improve photovoltaic efficiencies involves a templating-assisted process to prepare highly porous layers with well-ordered and accessible pores as well as improved crystallites connectivity. This talk especially focuses on the templating-assisted synthesis of TiO2 and ZnO semiconducting layers used as photoelectrode in DSSCs. Due to the surface area improvement as well as the perfect control of the pore organization and the pore size, the templating strategy is an effective solution to maximize the adsorption of active dye and the electrolyte infiltration inside the porous network. Besides, in the last few years, there has been increasing interest in electrochromic glazing due to its potential use as an energy-efficient component for buildings, as it could reduce considerably their CO2 emission by decreasing their energy consumption up to 30%. The crucial issues of such devices are the durability, the coloration efficiency and the reversibility upon coloration and bleaching of the electrochromic layers. In order to improve the performances of those electrochromic films, we have investigated a surfactant-assisted deposition process for WO3 layer and the insertion of lithium in the NiO layer. All films have been deposited on FTO glass substrates by ultrasonic spray pyrolysis (USP), which is a low-cost alternative to industrial vacuum processes for manufacturing high quality thin films. The presence of lithium ions in nickel oxide films has shown improved coloration efficiency compared to the undoped films. The higher active surface of surfactant-assisted tungsten oxide films has led to higher reversibility and coloration contrast. [less ▲]

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