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See detailSubstrats neuronaux de l'encodage non réussi dans le vieillissement
François, Sarah ULg; Angel, Lucie; Salmon, Eric ULg et al

Conference (2016, May 27)

Objectifs En utilisant l'IRM fonctionnelle, nous nous sommes intéressés à l'effet de l'âge sur les substrats neuronaux de l'encodage non réussi – l'activation à l'encodage pour les items oubliés par la ... [more ▼]

Objectifs En utilisant l'IRM fonctionnelle, nous nous sommes intéressés à l'effet de l'âge sur les substrats neuronaux de l'encodage non réussi – l'activation à l'encodage pour les items oubliés par la suite. Méthodologie Dans un scanner IRM, nous avons soumis des volontaires (20 jeunes et 19 âgés) à une tâche de mémoire épisodique avec consignes d'encodage incident. Durant celle-ci, des dessins d'objets en noir et blanc leur étaient présentés. Il leur était demandé d'effectuer un jugement de taille sur ces objets. Ensuite, toujours dans le scanner, les objets de la phase d'encodage ainsi que de nouveaux objets leurs étaient présentés afin d'évaluer leur reconnaissance de ceux-ci. Pour ce faire, les volontaires effectuaient un jugement de Recollection/Familiarité/Nouveauté. Résultats Les résultats comportementaux montrent une recollection altérée mais une familiarité préservée chez nos volontaires âgés. L'analyse des résultats IRM a été effectuée selon un design évènementiel (SPM8), dans lequel nous avons comparé les aires cérébrales activées à l'encodage pour les items qui n'ont pas été reconnus ultérieurement et pour ceux qui ont donné lieu à un jugement de recollection (p<.001 non-corrigé). Dans les deux groupes, un pattern d'activation correspondant au réseau du mode par défaut (RMD). Chez les volontaires âgés, les résultats ont également mis en évidence une activation supplémentaire du réseau attentionnel fronto-pariétal. Ensuite, le contraste entre les activations pour les items qui n'ont pas été reconnus ultérieurement et ceux qui ont donné lieu à un jugement de familiarité a aussi mis en évidence des régions du RMD, mais dans une moindre mesure. En effet, les activités communes aux deux groupes d'âge n'ont montré qu'une activation du précuneus. Discussion Comparé à la recollection, l'oubli d'informations semble associé, à l'encodage, à un recrutement accru du RMD qui pourrait refléter une incapacité à mettre en place des processus d'encodage efficaces, à la fois chez les jeunes adultes et les adultes plus âgés. De plus, l'activation supplémentaire du réseau fronto-pariétal chez ces derniers pourrait indiquer un fonctionnement moins différencié des réseaux cérébraux associés à l'encodage en mémoire. Lorsque l'on compare l'oubli d'informations à la familiarité, l'activation moindre du RMD pourrait suggérer qu'un certain niveau d'activation du RMD (et donc la présence de pensées étrangères à la tâche) n'empêche pas forcément toute reconnaissance sur base d'un sentiment de familiarité. [less ▲]

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See detailAccounting for price endogeneity in airline itinerary choice models
Lurkin, Virginie ULg

Scientific conference (2016, May 26)

This study formulates an itinerary choice model that is consistent with those used by industry and corrects for price endogeneity using a control function that uses several types of instrumental variables ... [more ▼]

This study formulates an itinerary choice model that is consistent with those used by industry and corrects for price endogeneity using a control function that uses several types of instrumental variables. We estimate our models using database of more than 3 million tickets provided by the Airlines Reporting Corporation. Results based on Continental U.S. markets for May 2013 departures show that models that fail to account for price endogeneity overestimate customers' value of time and result in biased price estimates and incorrect pricing recommendations. Extensions to advanced discrete choice models show the importance of accounting for inter-alternative substitution for products that share similar departure times. [less ▲]

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See detailMassive transfusion in critical haemorrhage following trauma: Aren’t we missing something?
TONGLET, Martin ULg

in Journal of Emergency Medicine, Trauma and Acute Care (2016), 5

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See detailIn situ and laboratory mechanical characterization of a loess sequence from Middle Belgium
Delvoie, Simon ULg; Charlier, Robert ULg; Collin, Frédéric ULg

Conference (2016, May 25)

A 10 m thick loess (aeolian silt) layer located beside the Romont quarry (Eben-Emael, Middle Belgium) has been investigated in order to characterize the mechanical behaviour of the silty material. Cone ... [more ▼]

A 10 m thick loess (aeolian silt) layer located beside the Romont quarry (Eben-Emael, Middle Belgium) has been investigated in order to characterize the mechanical behaviour of the silty material. Cone penetration tests (CPT) have been performed with different cones (M1-type, M2-type and electric) in order to evaluate the influence of the cone on the mechanical behaviour interpretation. Concurrently, laboratory tests have been performed on undisturbed samples from core drillings. Laboratory tests consist of a physical characterization (grain size distribution, Atterberg limits) and a mechanical characterization (oedometer tests). This comprehensive investigation study focuses on the comparison of the loess characterization between in situ and laboratory approaches. CPT-based soil behaviour type charts are analyzed and compared with the Unified Soil Classification System. Many relations also exist in the literature between parameters obtained from CPT results and from laboratory tests. The study explores the existing relations between the cone resistance and the oedometer constrained modulus in order to verify the related coefficients proposed in the literature for silty material. [less ▲]

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See detailLes problématiques de la rénovation du stock bâti dans la ville de demain : résultats d’une étude initiale en Belgique.
Ruellan, Guirec ULg

in 34èmes Rencontres Universitaires de Génie Civil de l'AUGC, Liège, 25 au 27 mai 2016 (2016, May 25)

Pour atteindre les objectifs énergétiques de l’Union Européenne pour 2050, et plus largement les objectifs fixés à la dernière COP, le secteur de la construction et de l’habitat doit opérer sa mue vers un ... [more ▼]

Pour atteindre les objectifs énergétiques de l’Union Européenne pour 2050, et plus largement les objectifs fixés à la dernière COP, le secteur de la construction et de l’habitat doit opérer sa mue vers un modèle plus durable. En Belgique, cela passe par la rénovation et l’amélioration des performances du stock bâti existant. La présente étude porte sur l’identification des différents enjeux (environnementaux, économiques et sociaux) liées à la rénovation en Belgique et tente d’objectiver les barrières (de financement, de communication et de réglementation) à une augmentation du taux de rénovation, à travers une revue de littérature des différentes études et projets portant sur ce domaine en Belgique. Ces résultats initiaux devront permettre ultérieurement la conduite des recherches approfondies visant à la modélisation des effets de plusieurs stratégies possibles d’augmentation du taux de rénovation. [less ▲]

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See detailLa distribution par des véhicules électriques
Bay, Maud ULg; Limbourg, Sabine ULg

Scientific conference (2016, May 25)

The objective of vehicle routing problems is to design a set of efficient vehicle routes to provide goods from a depot to a set of customers satisfying specific constraints. Classical variants of these ... [more ▼]

The objective of vehicle routing problems is to design a set of efficient vehicle routes to provide goods from a depot to a set of customers satisfying specific constraints. Classical variants of these problems consider that routes are performed by internal combustion engine vehicles. These vehicles have a long and easy-to-restore driving range. However, due to the short driving range, long battery recharging times and the limited availability of charging infrastructure, routing algorithms for EV need to be developped. Maximizing the driving range of the vehicle leads to an examination of the main factors in energy consumption which are: the mass of the vehicle and its payload, engine efficiency, vehicle speed, the drive pattern, road grade, and vehicle recharge ability while driving. Results from this research will provide an optimal management of urban logistics where night delivery, through the use of those silent vehicles, remains one of the main benefits. [less ▲]

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See detailReprésentation d'intégrales stochastiques via la base de Haar
Esser, Céline ULg

Conference (2016, May 24)

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See detailTowards nzeb goal for newly built office buildings in Europe using high temperature cooling.
Randaxhe, François ULg; Lemort, Vincent ULg; Lebrun, Jean ULg

Conference (2016, May 24)

In the design phase of a building, many HVAC systems options are available to satisfy the basic requirements related to its use. The design engineer is responsible for considering various systems and ... [more ▼]

In the design phase of a building, many HVAC systems options are available to satisfy the basic requirements related to its use. The design engineer is responsible for considering various systems and recommending a system that will meet the project goals and perform as desired. In addition, high efficiency requirements are imposed to the HVAC equipments through strong regional regulation such as the Energy Performance of Buildings Directive which requires minimum efficiency of HVAC equipments in the market. In reaction, major improvements have been made by manufacturers to improve the performance of their systems and meet all these criteria. With the nearly zero energy goal for all newly constructed buildings in Europe after 2020, it seems very likely that the design of the future building should rely on today’s technology to meet these targets. The integration of High Temperature Cooling in buildings can bring a fresh perspective in this context. The study presents the sensitivity analysis of a primary system to chilled water supply temperature for a water cooled chiller with a cooling tower and a free-chilling heat exchanger. It allows a proper assessment of the impact of the chilled water temperature on the primary system performance. [less ▲]

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See detailHow to improve the valorisationprocess of End-Of-Life vehicles? LCA as a tool to help decision
Belboom, Sandra ULg; Lewis, Grégory; Bareel, Pierre-François et al

Conference (2016, May 24)

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See detailComportement des structures soumises au feu
Gernay, Thomas ULg

Learning material (2016)

Les incendies représentent une sollicitation importante pouvant agir sur les bâtiments et autres structures du génie civil. Ce cours vise à donner un aperçu de la problématique du feu vis-à-vis des ... [more ▼]

Les incendies représentent une sollicitation importante pouvant agir sur les bâtiments et autres structures du génie civil. Ce cours vise à donner un aperçu de la problématique du feu vis-à-vis des structures et de la manière dont on peut concevoir ces dernières afin qu’elles assurent la sécurité des biens et des personnes en cas d’incendie. Les thèmes abordés couvriront la description des actions thermiques liées au développement d’un incendie et le comportement thermique et mécanique des matériaux à haute température. Les différents moyens de conception anti feu seront présentés ainsi que les méthodes de calcul pouvant mener à un dimensionnement viable face à cette sollicitation exceptionnelle. Finalement, le cours présentera des développements récents en ingénierie de la sécurité incendie et leur implémentation dans des projets réels de grande envergure. [less ▲]

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See detailRaised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis.
GUIOT, Julien ULg; Bondue, B.; HENKET, Monique ULg et al

in BMC pulmonary medicine (2016), 16(1), 86

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder of unknown origin, which ultimately leads to death. Several growth factors such as IGFs (insulin-like-growth factor) and IGFBPs ... [more ▼]

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder of unknown origin, which ultimately leads to death. Several growth factors such as IGFs (insulin-like-growth factor) and IGFBPs (insulin like growth factor binding proteins) seem to take part to the pathogenesis. We evaluated IGFs and IGFBPs in serum from patients with IPF and healthy subjects including 24 untreated IPF and 26 IPF receiving anti-fibrotic therapy and to compare them with healthy subjects. METHODS: Serum of 50 idiopathic pulmonary fibrosis and 55 healthy subjects (HS) were analysed by ELISA for IGFs and IGFBPs, TGF-beta and KL-6, the latter being tested as positive control in IPF. RESULTS: Serum levels of IGFBP-1 and IGFBP-2 and KL-6 were significantly higher in the IPF group than in the healthy subjects (p < 0.05, p < 0.001 and p < 0.0001 respectively) while the picture was inversed regarding IGFs. By contrast there was no significant difference between the groups with respect to TGF-beta. IGFBP-2 was significantly reduced in the patients with specific anti-fibrotic therapy pirfenidone and nintedanib compared to untreated patients (p < 0.05) but still significantly elevated in comparison to HS (p < 0.001). CONCLUSION: Serum IGFBP-1 and -2 are increased in idiopathic pulmonary fibrosis and IGFBP-2 may be reduced by anti-fibrosing therapy. IGFBPs may be promising biomarkers in IPF. [less ▲]

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See detailLes enjeux du binge-drinking chez les adolescents : réalités et enjeux sexués
Gavray, Claire ULg

Conference (2016, May 23)

Les loisirs des jeunes filles et garçons se rapprochent et à la fois leur consommation traduit toujours des injonctions de genre

Detailed reference viewed: 20 (3 ULg)
See detailAzraq Ayn Sawda Reservoir Project, Results of the 2013-2016 Seasons
Abu Azizeh, Lorraine; Bonnéric, Julie; Couturaud, Barbara ULg et al

Conference (2016, May 23)

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See detailStudy of microbial phenotypic heterogeneity under bioprocess conditions using « single-cell » techniques
Delepierre, Anissa ULg; Brognaux, Alison ULg; Baert, Jonathan ULg et al

Poster (2016, May 20)

Presentation of single-cell techniques in order to characterize microbial phenotypic heterogeneity: fluorescent labelling, biosensors, automated flow cytometry combined to proteomics approach.

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See detailCP-conserving multi-Higgs model with irremovable complex coefficients
Ivanov, Igor ULg; Silva, Joao

in Physical Review. D : Particles and Fields (2016), 93(9), 095014

Models beyond the Standard Model (bSM) often involve elaborate Higgs sectors, which can be a source of CP violation. It brings up the question of recognizing in an efficient way whether a model is CP ... [more ▼]

Models beyond the Standard Model (bSM) often involve elaborate Higgs sectors, which can be a source of CP violation. It brings up the question of recognizing in an efficient way whether a model is CP violating. There is a diffuse belief corroborated by all specific multi-Higgs models considered so far that the issue of explicit CP invariance can be linked to the existence of a basis in which all coefficients are real. Here, we prove that this belief is not justified. We present a CP-conserving three-Higgs-doublet model for which no real basis exists. The generalized CP symmetry of this model is of order 4, which leads to the peculiar property of the extra neutral Higgs bosons of being neither CP-even nor CP-odd but “half-odd” under this symmetry transformation. [less ▲]

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See detailEtude des mécanismes d'activation des récepteurs aux oestrogènes par l'estétrol et/ou la progestérone dans le sein normal et tumoral
Gallez, Anne ULg

Report (2016)

Estetrol (E4) is a natural estrogen we recently characterized as a Selective Estrogen Receptor Modulator (SERM) with agonistic and antagonistic activities depending on target cells. We have also evidenced ... [more ▼]

Estetrol (E4) is a natural estrogen we recently characterized as a Selective Estrogen Receptor Modulator (SERM) with agonistic and antagonistic activities depending on target cells. We have also evidenced the functional importance of mixed estrogenic/anti-estrogenic activities of E4 in normal breast development and cancer. Recent molecular studies, indicating that progesterone receptor (PGR) functions as a molecular rheostat to control ERα chromatin binding and transcriptional activity, have revolutionized our mechanistic insights of steroid receptor activities in malignant breast. E4 is a promising candidate for hormone replacement therapy (HRT) at menopause. However, the impact of the combined use of E4 and progesterone on normal breast physiology and on breast cancer development has not been evaluated yet. To fill this gap, we will evaluate the impact of treatments of E4 and/or progesterone on mammary gland development and breast cancer risk as well as on established breast cancer cells. We will unravel the molecular mechanisms driving the dual estrogenic/anti-estrogenic feature of E4 alone or combined to progesterone by evaluating the putative contribution of the extranuclear ERα, of GPER and by studying the modulation of ER/PGR interactions. This study will be conducted thanks to international collaborations (INSERM Toulouse, Reims, CNRS Rennes, Curie Institute Paris) we established through the EU SEPTIME project we coordinate. Through this project, we will bring new insights to the intriguing dual estrogenic/anti-estrogenic activity of E4. We will bring rational data about the putative safety of HRT combining E4 and progesterone. The development of an animal model assessing the effect of HRT on breast cancer risk in menopaused mice will also provide a useful tool to evaluate the effect of new HRT candidates on breast cancer risk. Moreover, the potential anti-tumor synergism of E4 and progesterone would contribute to the evolution of breast cancer treatment. [less ▲]

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