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See detailMultiple myeloma bone disease: from mechanisms to next generation therapy
Heusschen, Roy ULg; Muller, Joséphine ULg; WITHOFS, Nadia ULg et al

in Belgian Journal of Hematology (2017)

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See detailChapter 11 - Validation of Supercritical Fluid Chromatography Methods
Dispas, Amandine ULg; Lebrun, Pierre ULg; Hubert, Philippe ULg

in Poole, Colin (Ed.) Supercritical Fluid Chromatography - Handbook in Separation Science (2017)

Method validation is the process of proving that an analytical method is acceptable for its intended purpose. The present chapter defines the validation criteria described in regulatory documents. Despite ... [more ▼]

Method validation is the process of proving that an analytical method is acceptable for its intended purpose. The present chapter defines the validation criteria described in regulatory documents. Despite the abundance of guidelines, the conclusion about method validity remains confused. In this context, the state-of-the-art validation methodology named total error approach is briefly explained as the methodology that should be followed for all method validations. Finally, a review of literature presents quantitative development and validation of supercritical fluid chromatography (SFC) methods considering a wide range of applications and analytical fields. [less ▲]

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See detailPotential contribution of progesterone receptors to the development of sexual behavior in male and female mice.
Desroziers, Elodie; Brock, Olivier; Bakker, Julie ULg

in Hormones and Behavior (2017)

We previously showed that estradiol can have both defeminizing and feminizing effects on the developing mouse brain. Pre- and early postnatal estradiol defeminized the ability to show lordosis in ... [more ▼]

We previously showed that estradiol can have both defeminizing and feminizing effects on the developing mouse brain. Pre- and early postnatal estradiol defeminized the ability to show lordosis in adulthood, whereas prepubertal estradiol feminized this ability. Furthermore, we found that estradiol upregulates progesterone receptors (PR) during development, inducing both a male-and female-typical pattern of PR expression in the mouse hypothalamus. In the present study, we took advantage of a newly developed PR antagonist (ZK 137316) to determine whether PR contributes to either male- or female-typical sexual differentiation. Thus groups of male and female C57Bl/6j mice were treated with ZK 137316 or oil as control: males were treated neonatally (P0-P10), during the critical period for male sexual differentiation, and females were treated prepubertally (P15-P25), during the critical period for female sexual differentiation. In adulthood, mice were tested for sexual behavior. In males, some minor effects of neonatal ZK treatment on sexual behavior were observed: latencies to the first mount, intromission and ejaculation were decreased in neonatally ZK treated males; however, this effect disappeared by the second mating test. By contrast, female mice treated with ZK during the prepubertal period showed significantly less lordosis than OIL-treated females. Mate preferences were not affected in either males or females treated with ZK during development. Taken together, these results suggest a role for PR and thus perhaps progesterone in the development of lordosis behavior in female mice. By contrast, no obvious role for PR can be discerned in the development of male sexual behavior. [less ▲]

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See detailIgG4-related disease causing rapid evolution of a severe aortic valvular stenosis
BRULS, Samuel ULg; Courtois, Audrey ULg; DELVENNE, Philippe ULg et al

in The Annals of Thoracic Surgery (2017)

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See detailAn Analysis of the Interaction Effect between Employee Technical and Emotional Competencies in Emotionally Charged Service Encounters
Delcourt, Cécile ULg; Gremler, Dwayne; De Zanet, Fabrice ULg et al

in Journal of Service Management (2017), 28(1), 85-106

Purpose—Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them ... [more ▼]

Purpose—Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them in such emotionally charged service encounters (ECSEs) is crucial, considering the criticality of the encounter. Drawing on cognitive appraisal theory, this study proposes that two key competencies—employee emotional competence (EEC) and employee technical competence (ETC)—affect negative customer emotions and customer satisfaction with employee response in ECSEs. Design/methodology—This study relies on a video-based experiment that depicts a customer involved in an ECSE as a service provider delivers bad news to him. The hypothesis tests use a two-way independent analysis of covariance. Results—Both emotional and technical competencies must be displayed to improve the customer experience in an ECSE. When EEC is low, ETC does not decrease negative customer emotions or increase customer satisfaction with employee response. When EEC is high, ETC instead has a significant impact on both customer outcomes. Practical implications—Managers must train employees to develop both technical and emotional competencies. Employees who demonstrate only one type cannot temper customers’ emotions or enhance their perceptions of the employees’ response as well as can those strong in both competencies. Originality/value—Using a video-based experiment, this study examines the moderating role of EEC in the relationship between ETC and two key aspects of the customer experience in an ECSE (negative customer emotions and customer satisfaction with employee responses) following the delivery of bad news. [less ▲]

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See detailFalse memory susceptibility in coma survivors with and without a near-death experience
Martial, Charlotte ULg; Charland-Verville, Vanessa ULg; Dehon, Hedwige ULg et al

in Psychological Research (2017)

It has been postulated that memories of neardeath experiences (NDEs) could be (at least in part) reconstructions based on experiencers’ (NDErs) previous knowledge and could be built as a result of the ... [more ▼]

It has been postulated that memories of neardeath experiences (NDEs) could be (at least in part) reconstructions based on experiencers’ (NDErs) previous knowledge and could be built as a result of the individual’s attempt to interpret the confusing experience. From the point of view of the experiencer, NDE memories are perceived as being unrivalled memories due to its associated rich phenomenology. However, the scientific literature devoted to the cognitive functioning of NDErs in general, and their memory performance in particular, is rather limited. This study examined NDErs’ susceptibility to false memories using the Deese–Roediger–McDermott (DRM) paradigm. We included 20 NDErs who reported having had their experience in the context of a life-threatening event (Greyson NDE scale total score ≥7/32) and 20 volunteers (matched for age, gender, education level, and time since brain insult) who reported a life-threatening event but without a NDE. Both groups were presented with DRM lists for a recall task during which they were asked to assign “Remember/Know/Guess” judgements to any recalled response. In addition, they were later asked to complete a post-recall test designed to obtain estimates of activation and monitoring of critical lures. Results demonstrated that NDErs and volunteers were equally likely to produce false memories, but that NDErs recalled them more frequently associated with compelling illusory recollection. Of particular interest, analyses of activation and monitoring estimates suggest that NDErs and volunteers groups were equally likely to think of critical lures, but source monitoring was less successful in NDErs compared to volunteers. [less ▲]

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See detailA Large and Consistent Phylogenomic Dataset Supports Sponges as the Sister Group to All Other Animals.
Simion, Paul; Philippe, Herve; Baurain, Denis ULg et al

in Current Biology (2017)

Resolving the early diversification of animal lineages has proven difficult, even using genome-scale datasets. Several phylogenomic studies have supported the classical scenario in which sponges (Porifera ... [more ▼]

Resolving the early diversification of animal lineages has proven difficult, even using genome-scale datasets. Several phylogenomic studies have supported the classical scenario in which sponges (Porifera) are the sister group to all other animals ("Porifera-sister" hypothesis), consistent with a single origin of the gut, nerve cells, and muscle cells in the stem lineage of eumetazoans (bilaterians + ctenophores + cnidarians). In contrast, several other studies have recovered an alternative topology in which ctenophores are the sister group to all other animals (including sponges). The "Ctenophora-sister" hypothesis implies that eumetazoan-specific traits, such as neurons and muscle cells, either evolved once along the metazoan stem lineage and were then lost in sponges and placozoans or evolved at least twice independently in Ctenophora and in Cnidaria + Bilateria. Here, we report on our reconstruction of deep metazoan relationships using a 1,719-gene dataset with dense taxonomic sampling of non-bilaterian animals that was assembled using a semi-automated procedure, designed to reduce known error sources. Our dataset outperforms previous metazoan gene superalignments in terms of data quality and quantity. Analyses with a best-fitting site-heterogeneous evolutionary model provide strong statistical support for placing sponges as the sister-group to all other metazoans, with ctenophores emerging as the second-earliest branching animal lineage. Only those methodological settings that exacerbated long-branch attraction artifacts yielded Ctenophora-sister. These results show that methodological issues must be carefully addressed to tackle difficult phylogenetic questions and pave the road to a better understanding of how fundamental features of animal body plans have emerged. [less ▲]

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See detailA comparative study on optimum insulation thickness of walls and energy savings in equatorial and tropical climate
Kameni Nematchoua, Modeste; Ricciardi, Paola; Reiter, Sigrid ULg et al

in International Journal of Sustainable Built Environment (2017)

The increase outdoor temperature acts directly on the indoor climate of buildings. In Cameroon, the energy consumption demand in the buildings sector has been rapidly increasing in recent years; so well ... [more ▼]

The increase outdoor temperature acts directly on the indoor climate of buildings. In Cameroon, the energy consumption demand in the buildings sector has been rapidly increasing in recent years; so well that energy supply does not always satisfy demand. Thermal insulation technology can be one of the leading methods for reducing energy consumption in these new buildings. However, choosing the thickness of the insulation material often causes high insulation costs. In the present study, the optimum insulation thickness, energy saving and payback period were calculated for buildings in Yaounde´ and Garoua cities, located in two climatic regions in Cameroon. The economic model including the cost of insulation material and the present value of energy consumption and the cost over a life time of 22 years of the building, were used to find the optimum insulation thickness, energy saving, and payback period. Materials that extruded polystyrene were chosen and used for two typical wall structures (concrete block (HCB) and compressed stabilized earth block wall (CSEB)). The early cooling transmission loads, according to wall orientations and percentage of radiation blocked were calculated using the explicit finite-difference method under steady periodic conditions. As a result, it was found that the west- and east-facing walls are the least favourite in the cooling season, whereas the south and north orientations are the most economical. Although wall orientation had a significant effect on the optimum insulation thickness, it had a more significant effect on energy savings. In equatorial region (Yaounde´), for south orientation, the optimum insulation thickness was 0.08 m for an energy savings of 51.69 $/m2. Meanwhile, in tropical region (Garoua), for north orientation, the optimum insulation thickness was 0.11 m for an energy savings of 97.82 $/m2. [less ▲]

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See detailComparison of metabolic profiles and bioactivities of the leaves of three edible Congolese Hibiscus species
Kapepula, Paulin Mutwale; Kabamba Ngombe, Nadege; Tshisekedi Tshibangu, Pascal et al

in Natural Product Research (2017), 6419(March), 1--8

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See detailLa « personnalité antisociale », antithèse de la psychopathologie
Englebert, Jérôme ULg; Adam, Christophe

in Déviance et Société (2017), 41(1), 3-28

L’article propose une réflexion critique et clinique sur la notion de « personnalité antisociale », largement usitée dans le domaine de la nosographie des troubles mentaux et des pratiques « psy- » au ... [more ▼]

L’article propose une réflexion critique et clinique sur la notion de « personnalité antisociale », largement usitée dans le domaine de la nosographie des troubles mentaux et des pratiques « psy- » au sein du système de justice pénale. Notre réflexion débutera par une généalogie du vocable dans différentes versions de la classification psychiatrique, depuis les années cinquante jusqu’aujourd’hui, et plus particulièrement celle faisant autorité du Manuel statistique et diagnostique des troubles mentaux (DSM). L’absence de raisonnement sociologique dans l’usage d’une notion impliquant pourtant la référence au « social » sera discutée ainsi que ses évolutions historiques. Ensuite, la démonstration de l’antithèse que cette notion constitue pour une perspective psychopathologique digne de ce nom – dynamique, compréhensive et phénoménologique – sera développée en six arguments majeurs et plurivoques, tantôt empiriques et cliniques, tantôt théoriques. [less ▲]

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See detailCrise de la démocratie et nouveau management public : Discours, pratiques, instruments
Fallon, Catherine ULg; Ficet, Joël ULg

Book published by Academia (2017)

Les discours de légitimation du corps de doctrines et de dispositifs généralement associés sous le terme de « nouveau management public » (NMP) s’appuient non seulement sur un idéal de performance mais ... [more ▼]

Les discours de légitimation du corps de doctrines et de dispositifs généralement associés sous le terme de « nouveau management public » (NMP) s’appuient non seulement sur un idéal de performance mais aussi sur une aspiration à remédier à une « crise de la démocratie » qui se manifesterait par l’insatisfaction des populations des pays occidentaux vis-à-vis de leurs gouvernants, et ce de deux façons : en aidant les Etats à mieux répondre aux attentes de leurs populations d’une part, en créant au bénéfice des citoyens de nouvelles voies d’accès à la décision et de nouveaux droits d’autre part (DeLeon, 2005 ; Behn, 1998). Le livre rassemble des études interrogeant à partir de perspectives théoriques diverses (analyse des politiques publiques, sociologie des organisations, sciences de gestion, théorie politique…) la capacité des instruments du NPM à apporter une plus-value démocratique à la gestion publique et, inversement, analysant ce que le NPM nous révèle sur les transformations de la notion de démocratie dans un espace politique de plus en plus complexe et technocratique (Rose, 1991 ; Salais,2010; Ogien, 2013). Le NMP ne s’est pas construit en lui-même autour d’un impératif démocratique : dans sa version la plus pure, il consiste essentiellement, soit à confier au marché la réalisation d’un certain nombre de tâches relevant classiquement de l’administration (solution « anglo-saxonne »), soit à séparer la sphère politique de l’administration en responsabilisant les fonctionnaires en fonction d’objectifs de performance (solution « continentale »). Toutefois, certains de ses outils ont été conçus (à titre principal ou secondaire) comme moyens de promotion d’une logique démocratique, à même de contrer certains effets perçus comme pervers de la gestion publique : des instruments visant à faciliter le contrôle des administrations par les instances parlementaires ou juridictionnelles (Cour des comptes…) ; des instruments visant à accroître l’implication citoyenne dans la décision publique ; des instruments visant à améliorer la relation directe entre administration et citoyens (ombudsmen, sondages, cercles de qualité, chartes…) ; des instruments visant à accroître la transparence des processus administratifs et de leurs résultats (évaluation des politiques publiques, normes comptables) ; etc. Le pluralisme de ces dispositifs reflète à la fois l’hétérogénéité du NMP et l’ambiguïté du thème de la démocratie dès lors qu’appliqué à la responsabilité des acteurs politiques, ouvrant ainsi une opportunité d’analyse critique. Ainsi, les tenants des démarches d’évaluation défendent le rôle qu’elles peuvent jouer pour un approfondissement démocratique, par une meilleure lisibilité de l'action publique, une circulation des savoirs, un renforcement de la logique de responsabilité de l'administration et de son devoir de rendre des comptes. Certains auteurs, à l’inverse, dénoncent cette « idéologie de la gestion » (de Gaulejac, 2005) comme une colonisation du raisonnement politique par les catégories de l’économie et du management (Ogien, 2013), les chiffres structurant le processus décisionnel au lieu d’en être les simples auxiliaires, mathématisation du social (Salais, 2010) qui contribue à neutraliser les questions politiques et la délibération publique (Rose, 1991). Ces contributions permettent d’alimenter les réflexions sur la crise des formes contemporaines du politique à partir des analyses concrètes de l’action publique et des instruments mobilisés pour sa mise en œuvre. Cette posture permet d’interroger les processus de construction de ces instruments et les conditions concrètes de leur émergence, en dépassant la rationalité apparente des outils et l’image de « métrologues démiurges capables de maîtriser toutes les conséquences de l’introduction des instruments qu’ils ont retenus » (Mouhanna, 2011). [less ▲]

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See detailLocal planning in Belgium: a myriad of policy styles?
Wayenberg, Ellen; Reuchamp, Min; Kravagna, Marine et al

in Brans, Marleen; Aubin, David (Eds.) Policy Analysis in Belgium (2017)

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See detailNanomedicine as a potent strategy in melanoma tumor microenvironment
Pautu, Vincent ULg; Leonetti, Daniela; Lepeltier, Elise et al

in Pharmacological Research (2017)

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See detailDeveloping Situational Judgment Tests to Assess Organizational Citizenship Behaviours.
Lothe, Benoit ULg; Hansez, Isabelle ULg

Conference (2017)

This study is a first step towards addressing the development of Situational Judgment Tests (SJTs) for the assessment of Organizational Citizenship Behaviours (OCB). Based on relevant best practices and ... [more ▼]

This study is a first step towards addressing the development of Situational Judgment Tests (SJTs) for the assessment of Organizational Citizenship Behaviours (OCB). Based on relevant best practices and recommendations from the literature, two distinct SJTs were specifically developed to comply with OCB assessment. The two SJTs differ with respect to their degree of job specificity. Data were collected through online surveys on two different samples (220 white-collar professionals and 139 university students). Concurrently, OCB were collected using self-reported measurement scales. The findings provide some empirical evidence to support the appropriateness of using SJTs as an alternative means to assessing job applicants’ propensity to exhibit OCB. [less ▲]

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See detailAntiplasmodial activity of Mezoneuron benthamianum leaves and identification of its active constituents
Jansen, Olivia ULg; Tchinda, Alembert T.; Loua, Jean et al

in Journal of Ethnopharmacology (2017), 203(March), 20--26

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See detailLa méconnaissance du permis d'urbanisme et du permis d'urbanisation et ses conséquences autres que contractuelles dans la pratique notariale
Delnoy, Michel ULg; Charlier, Sophie

in Droit de l'urbanisme - CoDT et COBAT: quelles nouveautés pour la pratique notariale (2017)

Detailed reference viewed: 11 (0 ULg)