Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailJugement Situationnel
Lothe, Benoit ULg; Hansez, Isabelle ULg

in Brangier, Eric; Dubois, Michel; Valléry, Gérard (Eds.) et al Psychologie du Travail et des Organisations : 110 notions clés (2016)

Detailed reference viewed: 23 (1 ULg)
Full Text
Peer Reviewed
See detailSelenium in Cattle: A Review
Mehdi, Youcef ULg; Dufrasne, Isabelle ULg

in Molecules (2016), 21(4), 545

This review article examines the role of selenium (Se) and the effects of Se supplementation especially in the bovine species. Selenium is an important trace element in cattle. Some of its roles include ... [more ▼]

This review article examines the role of selenium (Se) and the effects of Se supplementation especially in the bovine species. Selenium is an important trace element in cattle. Some of its roles include the participation in the antioxidant defense the cattle farms. The nutritional requirements of Se in cattle are estimated at 100 μg/kg DM (dry matter) for beef cattle and at 300 μg/kg DM for dairy cows. The rations high in fermentable carbohydrates, nitrates, sulfates, calcium or hydrogen cyanide negatively influence the organism’s use of the selenium contained in the diet. The Se supplementation may reduce the incidence of metritis and ovarian cysts during the postpartum period. The increase in fertility when adding Se is attributed to the reduction of the embryonic death during the first month of gestation. A use of organic Se in feed would provide a better transfer of Se in calves relative to mineral Se supplementation. The addition of Se yeasts in the foodstuffs of cows significantly increases the Se content and the percentage of polyunsaturated fatty acids (PUFA) in milk compared to the addition of sodium selenite. The enzyme 5-iodothyronine deiodinase is a seleno-dependent selenoprotein. It is one of the last proteins to be affected in the event of Se deficiency. This delay in response could explain the fact that several studies did not show the effect of Se supplementation on growth and weight gain of calves. Enrichment of Se in the diet did not significantly affect the slaughter weight and carcass yield of bulls. The impact and results of Se supplementation in cattle depend on physiological stage, Se status of animals, type and content of Se and types of Se administration. Further studies in Se supplementation should investigate the speciation of Se in food and yeasts, as well as understanding their metabolism and absorption. This constitute a path to exploit in order to explain certain different effects of Se. [less ▲]

Detailed reference viewed: 55 (9 ULg)
Full Text
Peer Reviewed
See detailLagrangian and arbitrary Lagrangian Eulerian simulations of complex roll-forming processes
Crutzen, Yanick ULg; Boman, Romain ULg; Papeleux, Luc ULg et al

in Comptes Rendus Mécanique (2016), 344(4-5), 251-266

The Arbitrary Lagrangian Eulerian (ALE) formalism is a breakthrough technique in the numerical simulation of the continuous-type roll-forming process. In contrast to the classical Lagrangian approach, the ... [more ▼]

The Arbitrary Lagrangian Eulerian (ALE) formalism is a breakthrough technique in the numerical simulation of the continuous-type roll-forming process. In contrast to the classical Lagrangian approach, the ALE formalism can compute the hopefully stationary state for the entire mill length with definitely effortless set-up tasks thanks to a nearly-stationary mesh. In this paper, advantages of ALE and Lagrangian formalisms are extensively discussed for simulating such continuous-type processes. Through a highly complex industrial application, the ease of use of ALE modelling is illustrated with the in-house code METAFOR. ALE and Lagrangian results are in good agreement with each other. [less ▲]

Detailed reference viewed: 19 (11 ULg)
Full Text
Peer Reviewed
See detailEffectiveness of High Intensity Radial Shock Wave Therapy in The Treatment of Chronic Plantar Fasciitis
Demoulin, Christophe ULg; Vanderthommen, Marc ULg; Fromm, Aurélien et al

in European Journal of Physical and Rehabilitation Medicine (2016, April), 52(Suppl. 1 No. 2), 733

Introduction: Literature is scarce concerning the effectiveness of high dose radial extracorporeal shock wave therapy (ESWT). Therefore, the aim of this study was to investigate its effectiveness on pain ... [more ▼]

Introduction: Literature is scarce concerning the effectiveness of high dose radial extracorporeal shock wave therapy (ESWT). Therefore, the aim of this study was to investigate its effectiveness on pain, function and pressure pain threshold in patients with chronicplantar fasciitis (PF). Materials and Methods: Patients with a diagnosis of chronic (pain lasting for more than 3 months) uni- or bilateral PF with a history of failed conservative treatment were included. After a 6-week control period during which no treatment occurred, a 2-week treatment period followed by a three weeks of rest (cicatrization phase) was provided. The treatment period consisted of three radial ESWT sessions (2000 impulses of 10 Hz frequency per session with an energy flux density of 0,275mJ/mm2) separated by a one-weekinterval. Patient assessments (pain intensity, foot function and pressure pain threshold (PPT) at the site of maximum local tenderness disability) were conducted at baseline, after the 6-week control phase (pre-treatment) and at the end of the cicatrization phase (post-treatment). Results: Thirty patients (19 women (63.3%)) with chronic PF and a mean age of 51.9±11 years were included in the present study. No drop-out occurred throughout the study period. No changes were observed at the pre-treatment assessment session except for pain intensity which decreased slightly but significantly (P<0.05). At the post-treatment session, highly significant (P<0.001) and clinically meaningful changes occurred for pain intensity (-34%), foot function score (-60%) and PPT (+68%). Conclusions: The present study suggests that high dose radial ESWT is a feasible and effective way to quickly and significantly decrease pain and disability in most patients with chronic PF. [less ▲]

Detailed reference viewed: 73 (6 ULg)
Full Text
Peer Reviewed
See detailImproved Thévenin equivalent methods for real-time voltage stability assessment
Perez, Angel; Johannsson, Hjortur; Ostergaard, Jacob et al

in proc. IEEE ENERGYCON Conference (2016, April)

An improved Thévenin equivalent method for real-time voltage stability assessment that uses wide-area information from synchrophasors is proposed. The improvements are a better modeling of the limited ... [more ▼]

An improved Thévenin equivalent method for real-time voltage stability assessment that uses wide-area information from synchrophasors is proposed. The improvements are a better modeling of the limited synchronous generators, and a processing that anticipates the effect of field current limiters, before the latter are activated. Several study cases using detailed dynamic simulations of the Nordic test system have been used to assess the performance of the proposed improvements. Their effectiveness is analyzed and, based on the results, their possible application in combination with the sensitivity-based voltage stability assessment method is explored. [less ▲]

Detailed reference viewed: 51 (3 ULg)
Full Text
Peer Reviewed
See detailTreeNET: Discovering and Connecting Subnets
Grailet, Jean-François ULg; Tarissan, Fabien; Donnet, Benoît ULg

in 8th International Workshop on Traffic Monitoring and Analysis (TMA) (2016, April)

Since the early 2000's, the Internet topology has been an attractive and important research topic, either for developing data collection mechanisms, and for analyzing and modeling the network. Beside ... [more ▼]

Since the early 2000's, the Internet topology has been an attractive and important research topic, either for developing data collection mechanisms, and for analyzing and modeling the network. Beside traditional aspects of the Internet topology (i.e., IP interface, router, and AS levels), recent researches focused on intermediate promising visions of the topology, namely Point-of-Presence (PoP) and subnets (i.e., a set of devices that are located on the same connection medium and that can communicate directly with each other at the link layer). This paper focuses on network subnet discovery by proposing a new tool called treenet. One of the key aspects of treenet is that it builds a tree representing the way subnets are located with respect to each other. This tree allows treenet to obtain additional information on the network, leading to better analysis of the collected data. In this paper, we demonstrate the potential of treenet through the evaluation of its key algorithmic steps and the study of measurements collected from the PlanetLab testbed. [less ▲]

Detailed reference viewed: 61 (18 ULg)
Full Text
Peer Reviewed
See detailUnveiling the MPLS Structure on Internet Topology
Davila Revelo; Anderson Ricci, Mauricio; Donnet, Benoît ULg et al

in 8th International Workshop on Traffic Monitoring and Analysis (TMA) (2016, April)

Recently, researches have been conducted to discover and assess the usage of MPLS tunnels. Indeed, recent developments in the ICMP protocol make certain categories of MPLS tunnels transparent to ... [more ▼]

Recently, researches have been conducted to discover and assess the usage of MPLS tunnels. Indeed, recent developments in the ICMP protocol make certain categories of MPLS tunnels transparent to traceroute probing. Additional techniques have been proposed to reveal the presence of MPLS tunnels when they do not explicitly appear in traceroute. It has been shown that MPLS is a very well deployed technology whose usage (i.e., Traffic Engineering, load balancing, etc.) varies in time and according to ASes. However, the MPLS structure on the Internet architecture has not been studied yet. In this paper, we follow this path by providing two contributions to the state of the art: (i) we evaluate the biases involved on MPLS tunnel detection when they are not directly revealed through traceroute. (ii), we provide some properties and architectural details related with MPLS deployment on router topology based on a k-core decomposition. [less ▲]

Detailed reference viewed: 54 (5 ULg)
Peer Reviewed
See detailNon-invasive vagus nerve stimulation with the gammaCore® in healthy subjects: is there electrophysiological evidence for activation of vagal afferents ?
Schoenen, Jean ULg; NONIS, Romain ULg; D'Ostilio, Kevin ULg et al

Poster (2016, April)

Abstract: Background Non-invasive vagus nerve stimulation (nVNS) with the gammaCore® improves migraine and cluster headache. Animal experiments suggest that nVNS acts via stimulation of vagal afferents ... [more ▼]

Abstract: Background Non-invasive vagus nerve stimulation (nVNS) with the gammaCore® improves migraine and cluster headache. Animal experiments suggest that nVNS acts via stimulation of vagal afferents, but proof in humans is lacking. Vagal somatosensory evoked potentials (vSEP) are identified after invasive VNS or transcutaneous stimulation of auricular vagal branches, but late components could be muscle artifacts. Objective To search in healthy volunteers for reliable vSEP during nVNS with the gammaCore® Methods In 12 healthy subjects (7males) evoked potentials were recorded at A1/A2 (ref Cz) and C3/C4 (ref F3/F4) during 2-minute stimulation over left/right cervical vagus nerve with the gammaCore® (25Hz, 6-24V) and during stimulation over the inner tragus with a monopolar stimulator (2Hz, 50 stimuli, mean intensity 8mA). Results We identified 3 reproducible peaks P1, N1, P2 in 10 patients on the side of the gammaCore® stimulation at mean latencies of 2.05ms, 5.20ms and 9.13ms. P1-N1 amplitude increased significantly (p<0.01) with increasing voltage from 0.04μV to 0.52μV (C3/C4) and from 0.13µV to 2.04μV (A1/A2) respectively at 10V and 30V. Inner tragus stimulation elicited P1, N1, P2 peaks with shorter mean latencies (2.21ms, 3.72ms, 5.71ms) and a mean P1-N1 amplitude (A1/A2) of 5.0µV. When the gammaCore® was placed over the sternocleidomastoid muscle, there were no reproducible evoked potentials. Conclusion Non-invasive transcutaneous stimulation of the cervical vagus nerve with the gammaCore® elicits evoked potentials similar to those found with implanted electrodes or stimulation of Arnold’s nerve in the outer ear. The gammaCore®-evoked potentials increase in amplitude with stimulation intensity and disappear when the stimulator is positioned over neck muscles, suggesting that they are not muscle artifacts. Their short latency is compatible with their generation at the level of the foramen jugulare. The therapeutic effects reported with the gammaCore® in primary headaches can thus be mediated by genuine activation of vagus nerve afferents. [less ▲]

Detailed reference viewed: 49 (1 ULg)
Peer Reviewed
See detailAnodal transcranial direct stimulation (tDCS) targeting the anterior cingulate gyrus for the preventive treatment of chronic cluster headache: a proof of concept trial.
MAGIS, Delphine ULg; D'Ostilio, Kevin ULg; Cosseddu, Anna et al

Poster (2016, April)

Background There is a need for better treatments in chronic cluster headache (CCH). In responders to percutaneous occipital nerve stimulation, the subgenual anterior cingulate gyrus (sACG) was found ... [more ▼]

Background There is a need for better treatments in chronic cluster headache (CCH). In responders to percutaneous occipital nerve stimulation, the subgenual anterior cingulate gyrus (sACG) was found hypermetabolic (Magis et al. 2011). We reasoned that activation of this area by transcranial neurostimulation could be effective in CCH. Aim To explore the preventive effect of anodal (i.e. activating) transcranial direct current stimulation (tDCS) targeting the anterior cingulate gyrus in CCH patients. Method & subjects Difficult-to-treat CCH patients with a stable preventive drug regimen applied tDCS (2mA) interictally in 20-minute daily sessions for 4 weeks with the anode positioned over the forehead (FpZ), the cathode over the C7 spinous process. Therapeutic effects were monitored with paper diaries. Results Nineteen patients were enrolled up to now. In 13 patients who completed the trial, mean weekly attack frequency decreased by 38% after 4 weeks of daily stimulation (W-test: p = 0.002). The 50% responder rate was 54%. Patients (n=12) reported an improvement in headache impact, as shown by 5-point decrease in the mean HIT-6 score (from 67 to 62, p = 0.02). In 10 patients who were followed up after the treatment period, the benefit remained stable up to 4 weeks after the last stimulation. The first 3 enrolled patients had superficial skin burns under the adhesive cathode electrode. Sponge electrodes were therefore used in all subsequent patients without any adverse effect. Conclusion Anodal tDCS targeting the anterior cingulate gyrus seems promising for the preventive treatment of chronic cluster headache as suggested by this ongoing proof-of-concept trial. Use of adhesive electrodes is not recommended. [less ▲]

Detailed reference viewed: 29 (2 ULg)
Full Text
See detailMapping cortical modules, their connectivity and functions
Genon, Sarah ULg; Eickhoff, Simon

Conference (2016, April)

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailIs isokinetic exercise dangerous for the heart?
Le Goff, Caroline ULg; Kaux, Jean-François ULg; Cavalier, Etienne ULg et al

in European Journal of Physical and Rehabilitation Medicine (2016, April), 52(suppl. 1 No. 2), 457

INTRODUCTION: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in ... [more ▼]

INTRODUCTION: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in order to perform these very intensive exercises; otherwise an acute myocardial dysfunction could theoretically appear in predisposed patients. PURPOSE: Our study aimed to observe the cardiovascular impact (by biological point of view) of maximal intense isokinetic eccentric and concentric protocols performed by a population of sedentary young men. METHOD: Resting (T0) and post-exercise (just after (T1), 3 hours (T2) and 24 hours after the exercise (T3)) blood samples were taken in 2 populations of young sedentary men: 12 subjects (22.5±1.15 yo) for the eccentric protocol and 18 subjects (22.4±2.6 yo) for the concentric protocol. These subjects performed an intense maximal isokinetic exercise of the quadriceps muscles involving 30 knee flexions–extensions for each leg. We evaluated markers of cardiovascular risk (highly sensitive troponin T (hs-TnT), N-Terminal Brain natriuretic peptide (NT-proBNP), myoglobin (MYO)), of inflammation (highly sensitive C-reactive protein (hsCRP)), muscle damage (creatine kinase (CK)) and of oxidative stress (myeloperoxidase (MPO), lipidic peroxides (POXL), reduced (GSH) and oxidised glutathione (GSSG)). Haemodynamic parameters were measured continuously using a Portapres, and respiratory parameters were measured using a Sensormedics Vmax 29C. RESULTS: All the physiological parameters measured presented statistically significant changes. For the eccentric exercise, no significant modification in cardiac (NT-proBNP, hs-TNT) and inflammation (hsCRP) biomarkers was observed. However, a significant increase for CK (T3), MYO (T2), MPO (T1), POXL (T1), GSSG (T3) and ratio GSH/GSSG (T2-T3) was shown. For the concentric exercise, the results showed significant increases for the CK (T1-T2-T3), MYO (T1-T2), GSH/GSSG (T1). Evolutionary trends were also observed for the following biomarkers: NT-proBNP (T1-T2-T3), MPO (T2), and GSSG (T4). DISCUSSION and CONCLUSIONS: No modification in cardiac biomarkers was observed after the maximal eccentric isokinetic exercise but some variations can be observed for these biomarkers after the concentric exercise. However, these changes do not exceed the reference values in healthy subjects. We were thus able to prove that the exercise could be performed without any risk to cardiac function in young sedentary subjects. Nevertheless, a significant level of oxidative stress was induced by both exercises. [less ▲]

Detailed reference viewed: 34 (4 ULg)
Full Text
See detailStudy of the genetic structure of the African buffalo populations (Syncerus caffer): Impact of its high mobility and of the population fragmentation on its distribution and its interactions with humans
Smitz, Nathalie ULg

Doctoral thesis (2016)

The African continent still hosts a unique diversified megafaunal community. However, phylogeographical patterns of African species have not yet been largely studied, as compared to the North American and ... [more ▼]

The African continent still hosts a unique diversified megafaunal community. However, phylogeographical patterns of African species have not yet been largely studied, as compared to the North American and European species. Moreover, nowadays, the African ecosystems suffer of considerable anthropogenic pressures and of severe climatic modifications. Wildlife population fragmentation resulting from habitat loss, drought, poaching and diseases is currently threatening many African species survivals. The present thesis aimed at investigating the phylogeography and the population genetic structure of the African buffalo (Syncerus caffer) at different spatio-temporal scales (phylogeographical scale vs demographic scale), based on different molecular markers (mtDNA D-Loop region, 17 microsatellites and a large set of ‘Single Nucleotide Polymorphisms’ (SNPs)). The African buffalo is an emblematic key species and provides a powerful model to enhance our understanding of the African biogeography and the species conservation requirements. The aim of the first part of the present work was to reconstruct the evolutionary history of the African buffalo based on the study of the mtDNA D-Loop hypervariable region. More particularly, we aimed at studying the impact of the Quaternary climatic fluctuations on the species distribution (i.e. phylogeographical scale). Moreover, one of our purposes was also to investigate the taxonomic controversies linked to the extreme within species morphological variability, using molecular tools. From a sample set including all four morphologically recognized subspecies roaming the sub-Saharan African continent (hereafter called ecophenotypes), two taxonomic units were supported by genetics. The genetic discontinuity was located between the West-Central (S. c. nanus, S. c. brachyceros and S. c. aequinoctialis) and the South-Eastern populations (S. c. caffer). The low amount of genetic differentiation within each of these two units, or lineages, was attributed to a recent (in evolutionary term) Pleistocene expansion in both lineages, with rapid adaptation to a variety of habitats. Using both microsatellites and a large set of SNPs, the second part of the present thesis aimed at investigating the impact of human activities and recent climatic changes on the population structure of the species (i.e. demographic scale). While mtDNA did not allowed to distinguish finer sub-structuration within the two identified lineages, suggesting high female gene flow at an evolutionary timescale, these last molecular markers allowed to identify eight different populations at the continental level: two in West-Central Africa, three in Eastern and three in Southern Africa. Both ancient (Neolithic revolution) and recent anthropogenic activities were proposed to have shaped the demographic population structure observed in Southern and Eastern Africa. Recently, two of these populations were shown to be under significant genetic drift, following severe demographic bottlenecks. In these two cases, the sharp reduction in the size of the populations was proposed to be linked to disease eradication campaigns and to overharvesting during civil wars. Nevertheless, they did not display a significant loss in heterozygosity, indicating that they are still genetically healthy. Interestingly, at the contact region between the S. c. caffer and the S. c. aequinoctialis savanna ecophenotypes, a population displaying a shared genetic pool was also identified, corroborating the existence of hybrids between the different forms (intermediate morphological characteristics). In conclusion, using various genetic approaches and molecular markers, the present work gained insights into the taxonomy and the evolutionary history of the African buffalo, as well as in its conservation management requirements. [less ▲]

Detailed reference viewed: 31 (8 ULg)
Full Text
Peer Reviewed
See detailHistopathological effects of Aspergillus clavatus (Ascomycota: Trichocomaceae) on larvae of the southern house mosquito, Culex quinquefasciatus (Diptera: Culicidae)
Bawin, Thomas ULg; Seye, Fawrou; Boukraa, Slimane ULg et al

in Fungal Biology (2016), 120(4), 489-499

Aspergillus clavatus (Ascomycota: Trichocomaceae) was previously found to be an opportunistic pathogen of mosquitoes (Diptera: Culicidae). In the present study, the mechanism leading to its insecticidal ... [more ▼]

Aspergillus clavatus (Ascomycota: Trichocomaceae) was previously found to be an opportunistic pathogen of mosquitoes (Diptera: Culicidae). In the present study, the mechanism leading to its insecticidal activity was investigated regarding histological damages on Culex quinquefasciatus larvae exposed to A. clavatus spores. Multiple concentration assays using spore suspensions (0.5 x 10^8 to 2.5 x 10^8 spores/ml) revealed 17.0% to 74.3% corrected mortalities after 48 h exposure. Heat-deactivated spores induced a lower mortality compared to non-heated spores suggesting that insecticidal effects are actively exerted. Spore-treated and untreated larvae were prepared for light microscopy as well as for scanning and transmission electron microscopy. Spores failed to adhere to the external body surface (except the mouth parts) of these aquatic immature stages but progressively filled the digestive tract where their metabolism seemed to activate. In parallel, the internal tissues of the larvae, i.e. the midgut wall, the skeletal muscles, and the cuticle-secreting epidermis, were progressively destroyed between 8 and 24 h of exposure. These observations suggest that toxins secreted by active germinating spores of A. clavatus in the digestive tract altered the larval tissues, leading to their necrosis and causing larval death. Fungal proliferation and sporulation then occurred during a saprophytic phase. A. clavatus enzymes or toxins responsible for these pathogenic effects need to be identified in further studies before any use of this fungus in mosquito control. [less ▲]

Detailed reference viewed: 59 (19 ULg)
Full Text
Peer Reviewed
See detailSafety and well-being: an integrated model predicting safety behaviors
Laurent, Julie ULg; Chmiel, Nik; Hansez, Isabelle ULg

Conference (2016, April)

Since Hofmann, Jacobs and Landy (1995) emphasized the need to consider the influences of socio-organizational factors on safety, several studies have invoked psychological processes in order to interpret ... [more ▼]

Since Hofmann, Jacobs and Landy (1995) emphasized the need to consider the influences of socio-organizational factors on safety, several studies have invoked psychological processes in order to interpret the relationships they identified between such organizational factors and safety outcomes. However, studies measuring effectively such psychological processes are quite scarce. Four distinct psychological processes have been identified as fundamental to predict safety behaviors: cognitive, motivational, instrumental and social exchange processes. Hansez and Chmiel (2010) have applied the job demands resources model (Bakker & Demerouti, 2007) to the safety domain, identifying 3 different safety specific (instrumental) and non-safety specific (cognitive and motivational) psychological processes explaining safety violations. Our main aim is to integrate the four psychological processes, but also in-role and extra-role safety behaviors to the same model. More specifically, we aim at replicating Hansez and Chmiel’s (2010) results on a different sample and integrating safety-specific social process to the model. 1,922 workers (71% response rate) returned a questionnaire including validated scales measuring job demands (work overload and role ambiguity), job resources (job quality, decision latitude and work support), job strain, job engagement, perceived management commitment to safety, routine and situational violations, safety participation and safety citizenship role definitions (SCRDs). Data were analyzed using structural equation modelling and bootstrapping. Results showed that, as expected, our model followed the same patterns as Hansez and Chmiel’s (2010) model, confirming the importance of cognitive-energetical, motivational and instrumental processes in the prediction of safety violations. Moreover, perceiving management as committed to safety leads workers to define discretionary safety behaviours as part of the job, which is linked to corresponding discretionary behaviours. Participating in such discretionary activities, in turn, leads to (1) lower situational violations, but also to (2) lower routine violations. These results confirm the importance of safety-specific social exchange processes in the prediction of safety violations. Thus, it appears that different processes of reaction to working conditions can impact employee’ safety behaviors. On the one hand, situational violations are impacted by motivational process, as job resources encourage employees to be stimulated by their job, by instrumental process, as perceiving management as committed to safety is directly associated with lower situational violations, and by social process stemming from job resources (i.e. job resources allow employees to perceive their management as committed to safety, and they reciprocate this interest by defining safety as a part of their role, what encourage them to participate to discretionary safety activities). On the other hand, routine violations are impacted by the same social exchange (although to a lesser extent) and motivational processes, but also by cognitive process, as demanding working conditions may provoke job strain, associated with more “corner-cutting”. A practical implication for companies who want to reduce safety violations is to consider safety-specific and non-safety specific processes together. That is, they can try to improve working conditions considered as job resources, but need to keep in mind that these resources determine more complex safety-specific social exchange processes, through the crucial influence of management. [less ▲]

Detailed reference viewed: 38 (4 ULg)
Full Text
Peer Reviewed
See detailFibulin-3 fragments are prognostic biomarkers of osteoarthritis incidence in overweight and obese women
Runhaar, Jos; Sanchez, Christelle ULg; Taralla, Sébastien et al

in Osteoarthritis Cartilage (2016), 24(4), 672-678

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg ... [more ▼]

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg/m2, free of knee OA, were recruited. Using binary logistic regression, the association between baseline concentration of serum fibulin (Fib)3-1, Fib3-2 and Fib3-3 and incidence of clinical and radiographic knee OA after 30 months of follow-up was evaluated. RESULTS: Baseline and follow-up measurements were available for 241 women with a mean age of 55.9 +/- 3.2 years and mean BMI of 31.7 +/- 3.6 kg/m2. None of the concentrations of the three Fib3 epitopes were associated with the incidence of medial or lateral joint space narrowing (JSN) >/=1.0 mm or the incidence of Kellgren & Lawrence (K&L) grade >/=2 after 30 months. All three Fib3 epitopes were associated with the incidence of the clinical and radiographic ACR-criteria and Fib3-1 and Fib3-3 also with chronic pain at follow-up. When adjusted for the other Fib3 peptide concentrations, only Fib3-1 was significantly associated to the incidence of the American College of Rheumatology (ACR)-criteria (OR 3.2 [1.2-8.7]) and chronic pain at follow-up (OR 3.0 [1.2-7.7]). CONCLUSIONS: Baseline fibulin-3 concentrations are associated with the incidence of clinical knee OA among middle-aged overweight and obese women. Therewith, they meet the criteria of a prognostic biomarker according to the BIPED biomarker classification for OA. Further validation of the fibulin-3 epitopes seems warranted in order to better distinguish subgroups of individuals at increased risk for knee OA development. [less ▲]

Detailed reference viewed: 19 (4 ULg)
Full Text
Peer Reviewed
See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULg; Lambert, Cécile ULg; Comblain, Fanny ULg et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 88

Detailed reference viewed: 24 (4 ULg)