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See detailAdaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
Marques, J.; Valle-Delgado, J.; Urbán, P. et al

in Nanomedicine : Nanotechnology, Biology, and Medicine (2017)

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See detailMultiple myeloma bone disease: from mechanisms to next generation therapy
Heusschen, Roy ULg; Muller, Joséphine ULg; WITHOFS, Nadia ULg et al

in Belgian Journal of Hematology (2017)

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See detailChemical composition, vasorelaxant, antioxidant and antiplatelet effects of essential oil of Artemisia campestris L. from Oriental Morocco
Dib, Ikram; Fauconnier, Marie-Laure ULg; Sindic, Marianne ULg et al

in BMC Complementary and Alternative Medicine (2017), 17(art. 82), 1-15

Background: Artemisia campestris L. (Asteraceae) is a medicinal herb traditionally used to treat hypertension and many other diseases. Hence, this study is aimed to analyze the essential oil of A ... [more ▼]

Background: Artemisia campestris L. (Asteraceae) is a medicinal herb traditionally used to treat hypertension and many other diseases. Hence, this study is aimed to analyze the essential oil of A. campestris L (AcEO) and to investigate the antiplatelet, antioxidant effects and the mechanisms of its vasorelaxant effect. Methods: The chemical composition of AcEO was elucidated using GC/MS analysis. Then, the antioxidant effect was tested on DPPH radical scavenging and on the prevention of β-carotene bleaching. The antiplatelet effect was performed on the presence of the platelet agonists: thrombin and ADP. The mechanism of action of the vasorelaxant effect was studied by using the cellular blockers specified to explore the involvement of NO/GC pathway and in the presence of calcium channels blockers and potassium channels blockers. Results: AcEO is predominated by the volatiles: spathulenol, ß-eudesmol and p-cymene. The maximal antioxidant effect was obtained with the dose 2 mg/ml of AcEO. The dose 1 mg/ml of AcEO showed a maximum antiplatelet effect of, respectively 49.73% ±9.54 and 48.20% ±8.49 on thrombin and ADP. The vasorelaxation seems not to be mediated via NOS/GC pathway neither via the potassium channels. However, pretreatment with calcium channels blockers attenuated this effect, suggesting that the vasorelaxation is mediated via inhibition of L-type Ca2+ channels and the activation of SERCA pumps of reticulum plasma. Conclusion: This study confirms the antioxidant, antiplatelet and vasorelaxant effects of A.campestris L essential oil. However, the antihypertensive use of this oil should be further confirmed by the chemical fractionation and subsequent bio-guided assays. [less ▲]

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See detailSartre in Venedig: der Mann, der in die Kälte ging
Cormann, Grégory ULg; Viehöver, Vera ULg

in Bulletin d'Analyse Phénoménologique (2017), 11

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See detailLa tradition textuelle de la Continuation du ‘Roman de Guiron’
Veneziale, Marco ULg

in Duval, Frédéric; Leonardi, Lino; Trachsler, Richard (Eds.) Congrès international de linguistique et de philologie romanes (Nancy, 15-20 juillet 2013). Section 13 : Philologie textuelle et éditoriale (2017)

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See detailParecidos estilísticos entre Nellie Campobello y Juan Rulfo
Vanden Berghe, Kristine ULg

in Palou, Pedro Angel; Ramírez Santacruz, Francisco (Eds.) El llano en llamas, Pedro Páramo y otras obras (en el centenario de su autor) (2017)

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See detailThoracic endovascular aortic repair (TEVAR) in proximal (type A) aortic dissection: Ready for a broader application?
Nienaber, Christoph A.; Sakalihasan, Natzi ULg; Clough, Rachel E. et al

in Journal of Thoracic and Cardiovascular Surgery (The) (2017)

OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role ... [more ▼]

OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role in managing proximal aortic pathologies is unknown-this is important because in proximal (Stanford type A) aortic dissections, 10% to 30% are not accepted for surgery and 30% to 50% are technically amenable for TEVAR. We describe our case series of type A aortic dissections treated by using TEVAR. METHODS: Between year 2009 and 2016, 12 patients with acute, subacute, or chronic type A aortic dissection with the proximal entry tear located between the coronaries and brachiocephalic artery were treated with TEVAR at 3 centers. Various stent-graft configurations were used to seal the proximal entry tear in the ascending aorta under rapid pacing. RESULTS: A total of 12 patients (9 male, 3 female), mean age 81 +/- 7 years, EuroSCORE II 9.1 +/- 4.5, underwent TEVAR for the treatment of type A aortic dissection. Procedural success was achieved in 11 of 12 patients (91.7%). There was 1 minor stroke and 1 intraprocedural death. No additional deaths were reported at 30 days. At 36 months, there were 4 further deaths (all from nonaortic causes). The mean survival of these 4 deceased was 23 months (range 15-36 months). Follow-up computed tomography demonstrated favorable aortic remodeling. CONCLUSIONS: TEVAR is feasible and reveals promising early results in selected patients with type A aortic dissection who are poor candidates for surgical repair. The current iteration of stent-graft technology, however, needs to be adapted to features specific to the ascending aorta. [less ▲]

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See detailNew computational method of the ball/race contacts transverse loads of high speed ball bearings without race control hypothesis
Servais, Christophe ULg; Bozet, Jean-Luc ULg

in Tribology International (2017)

Some hypotheses are still necessary in order to access the ball bearing Newtonian equilibrium with quasi-static methods. Among these hypotheses are the values of the transverse loads within ball/race ... [more ▼]

Some hypotheses are still necessary in order to access the ball bearing Newtonian equilibrium with quasi-static methods. Among these hypotheses are the values of the transverse loads within ball/race contacts. Those loads are due to the gyroscopic torques. Nowadays, the transverse loads are estimated without any equilibrium criterion by the specialized literature. Moreover, the race control assumption is often employed in addition to the hypotheses made about the transverse loads. The paper describes a new method to compute the transverse loads without using the race control assumption. Then, a correlation between the ball bearing kinematics and the transverse loads is established. It leads to an accurate and efficient computational method to access the Newtonian equilibrium of high speed ball bearings. [less ▲]

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See detailInhibition of ethylene synthesis reduces salt-tolerance in tomato wild relative species Solanum chilense
Gharbi, E.; Martínez, J.-P.; Benahmed, H. et al

in Journal of Plant Physiology (2017), 210

Exposure to salinity induces a burst in ethylene synthesis in the wild tomato halophyte plant species Solanum chilense. In order to gain information on the role of ethylene in salt adaptation, plants of ... [more ▼]

Exposure to salinity induces a burst in ethylene synthesis in the wild tomato halophyte plant species Solanum chilense. In order to gain information on the role of ethylene in salt adaptation, plants of Solanum chilense (accession LA4107) and of cultivated glycophyte Solanum lycopersicum (cv. Ailsa Craig) were cultivated for 7 days in nutrient solution containing 0 or 125 mM NaCl in the presence or absence of the inhibitor of ethylene synthesis (aminovinylglycine (AVG) 2 μM). Salt-induced ethylene synthesis in S. chilense occurred concomitantly with an increase in stomatal conductance, an efficient osmotic adjustment and the maintenance of carbon isotope discrimination value (Δ13C). In contrast, in S. lycopersicum, salt stress decreased stomatal conductance and Δ13C values while osmotic potential remained higher than in S. chilense. Inhibition of stress-induced ethylene synthesis by AVG decreased stomatal conductance and Δ13C in S. chilense and compromised osmotic adjustment. Solanum chilense behaved as an includer and accumulated high amounts of Na in the shoot but remained able to maintain K nutrition in the presence of NaCl. This species however did not stimulate the expression of genes coding for high-affinity K transport but genes coding for ethylene responsive factor ERF5 and JREF1 were constitutively more expressed in S. chilense than in S. lycopersicum. It is concluded that ethylene plays a key role in salt tolerance of S. chilense. © 2016 [less ▲]

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See detailDroit matériel européen - recueil de documentation
Van Cleynenbreugel, Pieter ULg

Learning material (2017)

This set of cases and materials contains the key judgments and legislative instruments discussed in the compulsory droit matériel européen course. Judgments are preceded by self-study questions aimed at ... [more ▼]

This set of cases and materials contains the key judgments and legislative instruments discussed in the compulsory droit matériel européen course. Judgments are preceded by self-study questions aimed at facilitating one's understanding of the legal reasoning underlying them. [less ▲]

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See detailSystemic biomarkers of collagen and elastin turnover are associated with clinically relevant outcomes in COPD.
Stolz, Daiana; Leeming, Diana Julie; Edfort Kristensen, Jacob Hull et al

in CHEST (2017)

BACKGROUND: Extracellular matrix remodeling (ECM) of the lung tissue releases protein fragments into the blood, where they may be detected as serological surrogate markers of disease activity in chronic ... [more ▼]

BACKGROUND: Extracellular matrix remodeling (ECM) of the lung tissue releases protein fragments into the blood, where they may be detected as serological surrogate markers of disease activity in chronic obstructive pulmonary disease (COPD). We aimed to assess the association of ECM turnover with severity and outcome of COPD. METHODS: In a prospective, observational, multicenter study including 506 patients with COPD, GOLD grades II-IV, we analyzed serum samples at stable state, exacerbation and 4 weeks after exacerbation, for a panel of 5 novel neo-epitopes including fragments of collagen type-III (C3M) and type-VI (C6M), pro-forms of collagen type-III (Pro-C3) and type-VI (Pro-C6) and neutrophil elastase-generated fragments of elastin (EL-NE) by ELISA. These neo-epitopes were also measured at stable state in a derivation cohort including 100 COPD patients. RESULTS: Serum levels of C3M, C6M, Pro-C3, Pro-C6 and EL-NE were associated with lung function. Patients with the lowest levels of Pro-C3 and Pro-C6 had more severe airflow limitation, hyperinflation, air trapping, and emphysema. Degradation of collagen type-III and -VI was associated with dyspnea. All ECM biomarkers, except Pro-C6, were increased at exacerbation as compared to stable state but, except EL-NE, did not differ between stable state and exacerbation follow-up in the crude and adjusted analyses. In Cox regression adjusted analyses, Pro-C3 was associated with a shorter time to exacerbation (HR 0.72[0.59-0.89] p=0.002) and Pro-C6 with survival (HR 2.09[1.18-3.71], p=0.011). CONCLUSIONS: Serum biomarkers of ECM turnover are significantly associated with disease severity and clinically relevant outcomes in COPD. [less ▲]

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See detailThiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stressinduced behaviours in mice
Markova, Nataliia; Bazhenova, Nataliya; Anthony, Daniel C et al

in Progress in Neuro-Psychopharmacology & Biological Psychiatry (2017), 75

Thiamine deficiency in the brain has been implicated in the development of dementia and symptoms of depression. Indirect evidence suggests that thiamine may contribute to these pathologies by controlling ... [more ▼]

Thiamine deficiency in the brain has been implicated in the development of dementia and symptoms of depression. Indirect evidence suggests that thiamine may contribute to these pathologies by controlling the activities of glycogen synthase kinase (GSK)-3β. While decreased GSK- 3β activity appears to impair memory, increased GSK-3β activity is associated with the distressed/depressed state. However, direct evidence for the effects of thiamine on GSK-3β function were not have not been reported. Here, we administered thiamine or, the more bioavailable precursor, benfotiamine at 200 mg/kg/day for 2 weeks to C57BL/6J mice, to determine whether treatment might affect behaviours that are known to be sensitive to GSK-3β activity and whether such administration impacts on GSK-3β expression within the brain. The mice were tested in models of contextual conditioning and extinction, a 5-day rat exposure stress test, and a modified swim test with repeated testing. Imipramine (7.5 mg/kg/day) was administered as a positive control for thiamine or benfotiamine. As for imipramine, both compounds inhibited the upregulation of GSK-3β induced by predator stress or repeated swimming, and reduced floating scores and the predator stress-induced behavioural changes in anxiety and exploration. Coincident, thiamine and benfotiamine improved learning and extinction of contextual fear, and the acquisition of the step-down avoidance task. Together, our data indicate that thiamine and benfotiamine have antidepressant/anti-stress effects in naïve animals that are associated with reduced GSK-3β expression. Importantly, the treatment also had pro-cognitive actions despite the impact on GSK-3β activity. [less ▲]

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See detailThiamine: Biological forms and function
Bettendorff, Lucien ULg

Conference (2017)

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See detailMechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation
Mitrossilis, Démosthène; Röper, Jens-Christian; Roy, Damien Le et al

in Nature Communications (2017), 8

Animal development consists of a cascade of tissue differentiation and shape change. Associated mechanical signals regulate tissue differentiation. Here we demonstrate that endogenous mechanical cues also ... [more ▼]

Animal development consists of a cascade of tissue differentiation and shape change. Associated mechanical signals regulate tissue differentiation. Here we demonstrate that endogenous mechanical cues also trigger biochemical pathways, generating the active morphogenetic movements shaping animal development through a mechanotransductive cascade of Myo-II medio-apical stabilization. To mimic physiological tissue deformation with a cell scale resolution, liposomes containing magnetic nanoparticles are injected into embryonic epithelia and submitted to time-variable forces generated by a linear array of micrometric soft magnets. Periodic magnetically induced deformations quantitatively phenocopy the soft mechanical endogenous snail-dependent apex pulsations, rescue the medio-apical accumulation of Rok, Myo-II and subsequent mesoderm invagination lacking in sna mutants, in a Fog-dependent mechanotransductive process. Mesoderm invagination then activates Myo-II apical accumulation, in a similar Fog-dependent mechanotransductive process, which in turn initiates endoderm invagination. This reveals the existence of a highly dynamic self-inductive cascade of mesoderm and endoderm invaginations, regulated by mechano-induced medio-apical stabilization of Myo-II. [less ▲]

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See detailA surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH)
Farhat, Khalil; Bodart, Gwennaelle; Martens, Henri ULg et al

in Neuroimmunomodulation (2017)

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See detailBenchmark et analyse des écarts pour la planification d'urgence externe relative au risque Seveso
Thiry, Aline ULg; Verhaegen, Marlies; Fallon, Catherine ULg et al

Report (2017)

La recherche commanditée par le SPF Intérieur a mobilisé différentes méthodologies: au total près de 200 acteurs industriels et acteurs publics - de la planification d’urgence et de la gestion de ... [more ▼]

La recherche commanditée par le SPF Intérieur a mobilisé différentes méthodologies: au total près de 200 acteurs industriels et acteurs publics - de la planification d’urgence et de la gestion de crise en Belgique ont été invités à participer à l’enquête à travers des entretiens et un questionnaire Mesydel en ligne. Un benchmark a également été effectué dans 5 pays voisins à l’aide de questionnaires écrits et d’entretiens téléphoniques. L’objectif a été de mettre en évidence les difficultés rencontrées en matière de planification d’urgence externe pour les entreprises Seveso seuil haut en Belgique et d’identifier les (bonnes) pratiques dans les pays voisins. [less ▲]

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See detailFrançois Ier et les arts du Nord (1515-1547). Des liens à explorer et à appronfondir encore
Fagnart, Laure ULg; Lecocq, Isabelle

in Fagnart, Laure; Lecocq, Isabelle (Eds.) François Ier et les arts du Nord (1515-1547) (2017)

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See detailJean Clouet vs Joos van Cleve
Fagnart, Laure ULg

in Fagnart, Laure; Lecocq, Isabelle (Eds.) François Ier et les arts du Nord (1515-1547) (2017)

Detailed reference viewed: 17 (1 ULg)