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See detailImportance of structural damping in the dynamic analysis of compliant deployable structures
Dewalque, Florence ULg; Rochus, Pierre ULg; Bruls, Olivier ULg

in Acta Astronautica (2015), 111

Compliant mechanisms such as tape springs are often used on satellites to deploy appendices, e.g. solar panels, antennas, telescopes and solar sails. Their main advantage comes from the fact that their ... [more ▼]

Compliant mechanisms such as tape springs are often used on satellites to deploy appendices, e.g. solar panels, antennas, telescopes and solar sails. Their main advantage comes from the fact that their motion results from the elastic deformation of structural components, unlike usual hinges or prismatic joints, the motion of which is dictated by contact surfaces. No actuators or external energy sources are required and the deployment is purely passive, which appears as a decisive feature for the design of low-cost missions with small satellites or cubesats. The mechanical behaviour of a tape spring is intrinsically complex and nonlinear involving buckling, hysteresis and self-locking phenomena. High-fidelity mechanical models are then needed to get a detailed understanding of the deployment process, improve the design and predict the actual behaviour in the space 0-g environment. In the majority of the previous works, dynamic simulations were performed without any physical representation of the structural damping. These simulations could be successfully achieved because of the presence of numerical damping in the transient solver. However, in this case, the dynamic response turns out to be quite sensitive to the amount of numerical dissipation, so that the predictive capabilities of the model are questionable. In this work based on numerical case studies, we show that the dynamic simulation of a tape spring can be made less sensitive to numerical parameters when the structural dissipation is taken into account. [less ▲]

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See detailDevelopment of novel SOlid Materials for high power Li polymer BATteries (SOMABAT). Recyclability of components.
Zubizarreta, Leire; Gil-Agusti, Mayte; Garcia. et al

in Lecture notes on Mobility (2015)

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See detailAllogeneic hematopoietic stem cell transplantation in solid organ transplant recipients: a retrospective, multicenter study of the EBMT
Basak, GW.; Wiktor-Jedrzejczak, W.; Labopin, M. et al

in American Journal of Transplantation (2015), 15

We conducted a questionnaire survey of the 565 European Society for Blood and Marrow Transplantation centers to analyze the outcome of allogeneic hematopoietic stem cell transplantation (alloSCT) in ... [more ▼]

We conducted a questionnaire survey of the 565 European Society for Blood and Marrow Transplantation centers to analyze the outcome of allogeneic hematopoietic stem cell transplantation (alloSCT) in recipients of solid organ transplantation (SOT). We investigated 28 patients with malignant (N=22) or nonmalignant diseases (N=6), who underwent 31 alloSCT procedures: 12 after kidney, 13 after liver, and three after heart transplantation. The incidence of solid organ graft failure at 60 months after first alloSCT was 33% (95% confidence interval [CI], 16–51%) for all patients, 15% (95% CI, 2–40%) for liver recipients, and 50% (95% CI, 19–75%) for kidney recipients (p = 0.06). The relapse rate after alloSCT (22%) was low following transplantation for malignant disorders, despite advanced stages of malignancy. Overall survival at 60 months after first alloSCT was 40% (95% CI, 19–60%) for all patients, 51% (95% CI, 16–86%) for liver recipients, and 42% (95% CI, 14–70%) for kidney recipients (p = 0.39). In summary, we show that selected SOT recipients suffering from hematologic disorders may benefit from alloSCT and experience enhanced long-term survival without loss of organ function. [less ▲]

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See detailSafety and efficacy of azacitidine in Belgian patients with high-risk myelodysplastic syndromes, acute myeloid leukaemia, or chronic myelomonocytic leukaemia: results of a real-life, non-interventional post-marketing survey
Beguin, Yves ULg; Selleslag, Dominik; Meers, Stef et al

in Acta Clinica Belgica (2015), 70

Objectives: We evaluated azacitidine (VidazaH) safety and efficacy in patients with myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), and chronic myelomonocytic leukaemia (CMML), in a real ... [more ▼]

Objectives: We evaluated azacitidine (VidazaH) safety and efficacy in patients with myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), and chronic myelomonocytic leukaemia (CMML), in a real-life setting. Treatment response, dose, and schedule were assessed. Methods: This non-interventional, post-marketing survey included 49/50 patients receiving azacitidine at 14 Belgian haematology centres from 2010–2012. Treatment-emergent adverse events (TEAEs), including treatment-related TEAEs, and serious TEAEs (TESAEs) were recorded throughout the study. Treatment response [complete response (CR), partial response (PR), haematological improvement (HI), stable disease (SD), treatment failure (TF)) and transfusion-independence (TI) were evaluated at completion of a 1-year observation period (1YOP) or at treatment discontinuation, and overall survival (OS), at study conclusion. Results: The median age of patients was 74.7 (range: 43.9–87.8) years; 69.4% had MDS, 26.5% had primary or secondary AML, and 4.1% had CMML. Treatment-related TEAEs, grade 3–4 TEAEs, and TESAEs were reported in 67.3%, 28.6%, and 18.4% of patients, respectively. During 1YOP, patients received a median of 7 (1–12) treatment cycles. Treatment response was assessed for 38/49 patients. Among MDS and CMML patients (n529), 41.4% had CR, PR, or HI, 41.4% had SD, and 17.2% had TF. Among AML patients (n59), 44.4% had CR or PR, 33.3% had SD, and 22.2% had TF. TI was observed in 14/32 (43.8%) patients who were transfusion-dependent at baseline. Median (95% confidence interval) OS was 490 (326–555) days; 1-year OS estimate was 0.571 (0.422–0.696). Conclusions: Our data support previous findings that azacitidine has a clinically acceptable safety profile and shows efficacy. [less ▲]

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See detailError analysis of generalized-alpha Lie group time integration methods for constrained mechanical systems
Arnold, Martin; Bruls, Olivier ULg; Cardona, Alberto

in Numerische Mathematik (2015), 129(1), 149-179

Generalized-alpha methods are very popular in structural dynamics. They are methods of Newmark type and combine favourable stability properties with second order convergence for unconstrained second order ... [more ▼]

Generalized-alpha methods are very popular in structural dynamics. They are methods of Newmark type and combine favourable stability properties with second order convergence for unconstrained second order systems in linear spaces. Recently, they were extended to constrained systems in flexible multibody dynamics that have a configuration space with Lie group structure. In the present paper, the convergence of these Lie group methods is analysed by a coupled one-step error recursion for differential and algebraic solution components. It is shown that spurious oscillations in the transient phase result from order reduction that may be avoided by a perturbation of starting values or by index reduction. Numerical tests for a benchmark problem from the literature illustrate the results of the theoretical investigations. [less ▲]

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See detailSafety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes.
Scheen, André ULg

in Expert opinion on drug safety (2015), epub

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy a growing place in the armamentarium of drugs used for the management of hyperglycemia in type 2 diabetes, although some safety ... [more ▼]

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy a growing place in the armamentarium of drugs used for the management of hyperglycemia in type 2 diabetes, although some safety concerns have been raised in recent years. Areas covered: An updated review providing an analysis of available safety data (meta-analyses, randomized controlled trials, observational cohort and case-control studies and pharmacovigilance reports) with five commercialized DPP-4 inhibitors (sitagliptin, vildagliptin, saxagliptin, alogliptin, linagliptin). A special focus is given to overall safety profile; pancreatic adverse events (AEs) (acute pancreatitis, pancreatic cancer); overall cardiovascular safety (myocardial infarction and stroke); congestive heart failure concern and finally, safety in special populations (elderly, renal impairment). Expert opinion: The good tolerance/safety profile of DPP-4 inhibitors has been largely confirmed, including in more fragile populations (elderly, renal impairment) with almost no increased risk of infection or gastrointestinal AEs, no weight gain and a minimal risk of hypoglycemia. Although an increased risk of acute pancreatitis and pancreatic cancer was suspected, the complete set of available data appears reassuring so far. Cardiovascular safety of DPP-4 inhibitors has been proven but an unexpected increased risk of heart failure has been reported which should be confirmed in ongoing trials and better understood. Further postmarketing surveillance is recommended. [less ▲]

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See detailDevelopment and validation of the French version of a tool assessing patient's expectations in lower limb osteoarthritis
NEUPREZ, Audrey ULg; Delcour, JP; Fatemi, F et al

in Journal of Orthopaedics (2015), 12

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See detailJean-Marie KAJDANSKI, Pain gris, 2014.
Baiwir, Esther ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2015), (1/2015), 13-14

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See detailDe Bruxelles I à Bruxelles Ibis - Retouches aux règles de compétence
Boularbah, Hakim ULg

in Journal des Tribunaux (2015)

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See detailBridging Space Weather to Planetary Environments
Plainaki; Milillo; Andriopoulou et al

Conference (2015)

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See detailP. Carruthers, "Pour une théorie dispositionnelle de la pensée d'ordre supérieur"
Dewalque, Arnaud ULg

in Dewalque, Arnaud; Gauvry, Charlotte (Eds.) Conscience et Représentation. Controverses récentes en philosophie de l'esprit (2015)

Traduction française du célèbre chapitre de Peter Carruthers, "HOP over FOR, HOT Theory". L'auteur y soutient que les théories représentationnelles de premier ordre (Dretske, Tye, et alii) et les théories ... [more ▼]

Traduction française du célèbre chapitre de Peter Carruthers, "HOP over FOR, HOT Theory". L'auteur y soutient que les théories représentationnelles de premier ordre (Dretske, Tye, et alii) et les théories actualistes de la pensée d'ordre supérieur (e.g., Rosenthal) se heurtent à deux sérieuses difficultés: l'incapacité à rendre compte des concepts d'expérience recognitionnels et l'incapacité à expliquer pourquoi certains états sont phénoménalement conscients et d'autres non. P. Carruthers introduit et défend une théorie alternative, d'après laquelle un état mental est phénoménalement conscient si et seulement s'il est mis à la disposition d'une pensée d'ordre supérieur possible. Cette théorie est baptisée théorie dispositionnelle de la pensée d'ordre supérieur ou "théorie du double contenu". [less ▲]

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See detailThe Syntax-Semantics Interface in Earlier Egyptian: a Case Study in Verbs of Cognition
Winand, Jean ULg

in Allen, James P.; Collier, Mark; Stauder, Andréas (Eds.) Coping with Obscurity: the Brown Workshop on Earlier Egyptian Grammar (2015)

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See detailCorridor Report on Belgium : the case of Moroccan and Turkish Immigrants.
Gsir, Sonia ULg; Mandin, Jérémy ULg; Mescoli, Elsa ULg

Report (2015)

This report compares two important corridor migrations to Belgium in order to better understand the variation in several dimensions of Turkish and Moroccan immigrants’ integration – in particular, labour ... [more ▼]

This report compares two important corridor migrations to Belgium in order to better understand the variation in several dimensions of Turkish and Moroccan immigrants’ integration – in particular, labour market, education and citizenship. It is based on an original methodology combining three different data sources (an analysis of the legal and political frameworks, a quantitative analysis, and a survey). It aims to test the INTERACT project’s main hypothesis which conceives of integration as a three-way process. This report provides insight on integration from the immigration country perspective but also from the countries of origin; it appraises the impact that Turkey and Morocco may have on the integration of their migrants in Belgium. The main findings are the following. Firstly, the countries of origin may have an impact on integration when emigration starts. Secondly, countries of origin may have a positive or negative impact on some integration dimensions (citizenship) but no obvious impact on others (education and labour market). In their efforts to maintain and develop links and to protect migrants’ rights abroad, countries of origin can thus facilitate integration, but indirectly. [less ▲]

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See detailMicrowave-assisted thermochemical and primary hydrolytic conversions of lignocellulosic resources: a review
Richel, Aurore ULg; Jacquet, Nicolas ULg

in Biomass Conversion and Biorefinery (2015), 5(1), 115-124

Faced with the inevitable depletion of fossil resources, agricultural productions have rapidly emerged as promising renewable alternatives. Particularly, the conversion of lignocellulosic materials has ... [more ▼]

Faced with the inevitable depletion of fossil resources, agricultural productions have rapidly emerged as promising renewable alternatives. Particularly, the conversion of lignocellulosic materials has nowadays opened new vistas for the production of energy, biofuels and chemicals. In this literature review, microwave technology is described as an original heating source either for the thermochemical conversions (at temperatures up to 400°C) of lignocellulose into biofuels or the pretreatment (below 400°C) and further hydrolysis of lignocellulose into bioethanol and other valuable chemicals. Advantages of microwave approaches include a commonly observed acceleration in reaction rate and improved selectivities and yields. [less ▲]

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See detailSeymour de Ricci (1881-1942)
Carlig, Nathan ULg

in Capasso, Mario (Ed.) Hermae. Scholars and Scholarship in Papyrology, IV (2015)

Portrait bio-bibliographique papyrologique de l'érudit franco-anglais Seymour de Ricci (1881-1942).

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See detailChanges in pubertal timing: Past views, Recast issues
Bourguignon, Jean-Pierre ULg; Domine, Françoise; Glowacz, Fabienne ULg et al

in Bourguignon, Jean-Pierre; Carel, Jean-Claude; Christen, Yves (Eds.) Brain Crosstalk in Puberty in Adolescence (2015)

Abstract The aim of this article is to review some common opinions on changes in pubertal timing and shed new light both on the indicators used in assessing pubertal timing and the underlying mechanisms ... [more ▼]

Abstract The aim of this article is to review some common opinions on changes in pubertal timing and shed new light both on the indicators used in assessing pubertal timing and the underlying mechanisms. While emphasis is usually on advancement in timing of female puberty, it appears that timing also changes in males, both towards earliness for the initial pubertal stages and towards lateness for the final stages. Such findings suggest that the environmental influences on pubertal timing are more complex than initially thought. Moreover, self-evaluated pubertal timing versus peers provides information that is not always consistent with observations at physical examination, suggesting that both perspectives should be considered, especially when studying the correlation between pubertal timing and psychosocial aspects. The mechanisms of changes in pubertal timing may involve both central neuroendocrine control and peripheral effects in tissues targeted by gonadal steroids. Though energy availability is certainly a clue to the mechanism of pubertal development, changes in the control of both energy balance and control of reproduction may vary under the influence of common determinants such as endocrine-disrupting chemicals. These effects can take place right before puberty as well as much earlier, during fetal and neonatal life. Finally, environmental factors can interact with genetic factors in determining changes in pubertal timing. Therefore, the variance in pubertal timing is no longer to be considered under the absolutely separate control of environmental and genetic determinants.  [less ▲]

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See detailCorrélations entre différents tests destinés à évaluer la souplesse des ischio-jambiers
Demoulin, Christophe ULg; Wolfs, Sébastien ULg; Granado, Caroline et al

in Kinesitherapie Revue (2015), 15(158), 44-45

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See detailThe anti-angiogenic peptide Anginex blocks osteoclastogenesis
Muller, Joséphine ULg; Binsfeld, Marilène ULg; DUBOIS, Sophie ULg et al

in Belgian Journal of Hematology (2015), Abstracts book

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See detailEditorial. Un regard pluriel sur l’évaluation offert aux scientifiques francophones et construit par eux
Demeuse, Marc; Fagnant, Annick ULg; Dupriez, Vincent

in Evaluer. Journal international de recherche en éducation et formation (2015), 1(1), 5-10

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