Last 7 days     Results 1641-1660 of 39393.   78 79 80 81 82 83 84 85 86 87 88   Lire le futur du passé: villes et paysages de Meuse en projetOcchiuto, Rita Conference (2015, April 03)Detailed reference viewed: 13 (1 ULg) Quand la science se mêle de la gestion des eaux pluviales : Les services écosystémiques rendus par l'infrastructure verteMaréchal, Justine Conference given outside the academic context (2015)L'infrastructure verte joue un rôle dominant dans nos villes. Que ce soit d'un point de vue économique, environnemental ou social, chaque fois, cette infrastructure se révèle d'une importance cruciale. La ... [more ▼]L'infrastructure verte joue un rôle dominant dans nos villes. Que ce soit d'un point de vue économique, environnemental ou social, chaque fois, cette infrastructure se révèle d'une importance cruciale. La présentation s'intéressera dans un premier temps à comprendre les caractéristiques de cette infrastructure verte dans différentes villes belges. Dans un deuxième temps, un parallèle sera fait entre cette structure spatiale des espaces verts et un processus écologique bien précis : la gestion de l'eau pluviale. Pour aborder cette partie, une synthèse de différentes techniques d'aménagement du paysage seront présentées en tant que pistes de réflexion pour une gestion plus intégrée de l'eau de pluie en ville. [less ▲]Detailed reference viewed: 15 (3 ULg) Notizie dalla letteratura sicitaliana, ovvero siciliana e italiana (ed europea)Curreri, Luciano Article for general public (2015)Detailed reference viewed: 167 (7 ULg) Contribution to real-time inundation mapping in the Walloon regionStilmant, Frédéric ; Pirotton, Michel ; Goffin, Louis et alConference (2015, April 02)Detailed reference viewed: 22 (5 ULg) N1-(2-[18F]Fluoroethyl)-tryptophan: fully automated radiosynthesis, and study as potential substrate for indoleamine 2,3-dioxygenase PET imagingHenrottin, Jean ; Lemaire, Christian ; Zervosen, Astrid et alConference (2015, April 02)Detailed reference viewed: 17 (2 ULg) Analyse des propriétés anti-tumorales des exosomes endothéliaux dans le cancer du sein suite au transfert du microARN miR-503Bovy, Nicolas Doctoral thesis (2015)L’angiogenèse est un processus essentiel au développement tumoral ainsi qu’à la dissémination des métastases. De plus, il a été démontré ces dernières années que les miARN, des ARN non codant d'une ... [more ▼]L’angiogenèse est un processus essentiel au développement tumoral ainsi qu’à la dissémination des métastases. De plus, il a été démontré ces dernières années que les miARN, des ARN non codant d'une vingtaine de nucléotides régulant l’expression des gènes au niveau post-transcriptionnel, jouent un rôle important dans divers processus tumoraux. Ils ont en outre été détectés dans plusieurs fluides biologiques, protégés de la dégradation dans des microvésicules, les exosomes. Cependant, à l’heure actuelle, aucune information n’est connue sur le rôle des exosomes endothéliaux et des miARN qu’ils contiennent sur la croissance tumorale. Au cours de ce travail, nous avons pour la première fois mis en évidence l’existence d’un transfert de miARN des cellules endothéliales vers les cellules tumorales par l’intermédiaire d’exosomes. Nous avons ensuite identifié un miARN, miR-503, dont l’export dans ces microvésicules est modifié en conditions tumorales. L’analyse de la fonction du miARN dans les cellules tumorales de cancer du sein montre qu’il possède des propriétés anti-tumorales en réduisant la prolifération et l’invasion. Nous avons également observé que le miR-503 d’origine endothéliale génère les mêmes effets. Pour expliquer ces résultats, deux cibles du miARN ont été identifiées, CCND2 et CCND3. De plus, l’inhibition de ces dernières conduit au même phénotype qu’une surexpression de miR-503. Nous avons ensuite voulu déterminer si le niveau plasmatique de ce miARN était modulé chez des patientes atteintes de cancer du sein. Nos analyses révèlent une augmentation du niveau sanguin de miR-503 à la suite d’un traitement par chimiothérapie néoadjuvante. Nous avons de plus observé que des cellules endothéliales soumises aux mêmes agents chimiothérapeutiques sécrètent activement du miR-503 dans leurs exosomes. Il semble également que le changement phénotypique induit par miR-503 sur les cellules tumorales modifie leur production en facteurs angiogènes ce qui mène, en retour, à une inhibition de l’angiogenèse. Ces résultats montrent que miR-503 est un miARN anti-tumoral sécrété dans les exosomes de cellules endothéliales. Celui-ci provoque l’inhibition de la prolifération et de l’invasion de cellules tumorales du cancer du sein en ciblant CCND2 et CCND3. Ce processus pourrait être complémentaire des effets directs générés par la chimiothérapie sur la tumeur et favoriser la réponse de l’hôte dans le traitement de la maladie. [less ▲]Detailed reference viewed: 23 (5 ULg) Does high school program choice affect academic performance? Evidence for EconomicsLefevre, Mélanie Conference (2015, April 02)This study evaluates the impact of the choice of the Economics elective course in secondary school on the performance in Economics at the University level. While several studies look at the impact on ... [more ▼]This study evaluates the impact of the choice of the Economics elective course in secondary school on the performance in Economics at the University level. While several studies look at the impact on performance of the number of hours of mathematics in secondary school, less has been made regarding the impact of the secondary school Economics program. We match survey data from 360 students enrolled in the first year of the bachelors program in HEC-Management School of University of Liège, with administrative data and exam results. The methodological challenge is that students who choose Economics elective course in secondary school are likely to be different, in terms of motivation, from other students. To get rid of this potential bias, we approximate motivation using self-reported reasons for the choice of the elective courses, but also participation to non-mandatory tests and preparations before the exam. We also control for several individual characteristics (socio-economic background, age, gender, secondary school fixed effect, etc.) in order to compare students with similar abilities. Preliminary analysis shows that students who have chosen Economics elective course in the last year of secondary school do not perform better, or worse, at their University Economics exam, when controlling for the number of hours of mathematics they had in secondary school, as well as other individual characteristics. However, they are less likely to report their bachelor Economics course as being “difficult”. Overconfidence of students with higher previous economic knowledge may explain why they do not perform better than their peers. [less ▲]Detailed reference viewed: 18 (4 ULg) Application of stable isotopes in trophic ecology: importance of TEF and seasonal baseline for robust interpretations.Remy, François ; Darchambeau, François ; Dauby, Patrick et alConference (2015, April 02)Nitrogen, carbon and sulfur stable isotopes are very powerful tools for trophic ecologists to delineate food webs of various ecosystems. More recently… the use of mixing models has exponentially increased ... [more ▼]Nitrogen, carbon and sulfur stable isotopes are very powerful tools for trophic ecologists to delineate food webs of various ecosystems. More recently… the use of mixing models has exponentially increased to give a more specific vision of organism’s diets and trophic relationships. Two case studies will be presented to give a summary of what’s been done in Liège Oceanology Lab to improve our interpretation of stable isotopes results. First is an experimental calculation of the Trophic Enrichment Factors (TEFs) for one dominant detritivorous species of Mediterranean amphipod inhabiting seagrass detritus: Gammarus aequicauda (Martynov, 1931). This experimental study was planned after a strange result of the SAIR mixing model, giving results opposed to all observations and knowledge we had about this species. Thus, the impact of 3 very different food sources (amphipod powder, algae power, seagrass powder) on the turnover rate of C and N isotopic compositions was tested, and afterwards TEFs for C and N for each source were calculated. Animal food source showed to be the most effectively assimilated with a fast turnover rate while seagrass and algae showed very slow assimilation. TEFs calculations showed to be interesting because TEFs seem not to depend on the natural feeding type of the invertebrate but more on the type of food source. Animal source showed carnivorous TEFs values while seagrass and algae source showed typical detritivorous values. SIAR results with these new custom values gave more coherent values highlighting the major importance of TEFs values for mixing models data interpretation. Second is a simple question: are the seasonal isotopic composition variations observed for many seagrass detritus macrofauna species due to actual diet changes, or only to isotopic baseline shift of the food sources? Macrofauna and all potential food sources were sampled near STARESO Oceanographic Station (Corsica, 8°45’E; 42°35’N) in 2011-2012 at each season at two different sites. SIBER software runs with C and N isotopic data showed spatio-temporal isotopic variations at community, interspecific and intraspecific level. SIBER did not gave us information about the origin of these changes, but coupled with SIAR and our custom TEFs, species actually showing drastic changes of diet were identified, while others seem to reflect more a source baseline isotopic composition shift. Working at specific level is compulsory for fine conclusions. These two case studies highlight the importance of mixing model use and of accurate TEF values to run these models properly to draw robust and reliable conclusions using stable isotopic data. [less ▲]Detailed reference viewed: 57 (3 ULg) Introduction aux cartoons américains des années 1920 à 1928Tomasovic, Dick Scientific conference (2015, April 02)Panorama historique du cartoon américain des années 20Detailed reference viewed: 5 (0 ULg) Association of classical microbiology and 16S rDNA metagenetic Aanalysis to evaluate the presence of Clostridium difficile ina a belgian nursing homeRodriguez Diaz, Cristina ; Taminiau, Bernard ; Avesani, Véronique et alPoster (2015, April 01)Increasing age, several co-morbidities, environmental contamination, antibiotic exposure and other intestinal perturbations appear to be the greatest risk factors for C. difficile infection (CDI ... [more ▼]Increasing age, several co-morbidities, environmental contamination, antibiotic exposure and other intestinal perturbations appear to be the greatest risk factors for C. difficile infection (CDI). Therefore, elderly care home residents are considered particularly vulnerable to CDI. The main objective of this study was to evaluate and follow the prevalence of C. difficile in a Belgian nursing home. During a 4-month period, stool samples from a group of 23 elderly care home residents were collected weekly. A C. difficile microbiological detection scheme was performed along with an overall microbial biodiversity study of the faeces content by Targeted Metagenomic analysis. Culture of samples was performed in a selective medium cycloserine cefoxitin fructose cholate. An identification of the isolated colonies was done by PCR detection of tpi, tcdA, tcdB and cdtA genes. Toxic activity was confirmed by a cytotoxic immunoassay. Further characterization was performed by PCR ribotyping. The Metagenomic analysis was targeted on the v1-v3 hyper-variable region of 16S rDNA. The taxonomical assignment of the populations was performed with MOTHUR and Blast algorithms. Seven out of 23 (30.4%) residents were (at least one week) positive for C. difficile. The most common PCR-ribotype identified was 027. Targeted Metagenomic analyses reveals that each resident has his own bacterial imprint, which is stable during the entire study. Residents’ positives for C. difficile by classical microbiology showed an important proportion of C. difficile sequences. However, Metagenomics analysis can’t substitute targeted protocols. It was not used as a diagnostic tool to detect C. difficile but rather to determine the identification and correlations of the major bacterial populations that are present in the gut microbiota. In conclusion, this unique association of classical microbiology protocol with pyrosequencing allowed to follow C. difficile in patients and to identify several other bacterial populations whose abundance is correlated with C. difficile. [less ▲]Detailed reference viewed: 33 (0 ULg) Bibliométrie et Open Access à l'ULgThirion, Paul Scientific conference (2015, April 01)Detailed reference viewed: 487 (27 ULg) Usages de l'image dans les sciences de la vie : quelques réflexions constructivistesPieron, Julien Scientific conference (2015, April 01)Detailed reference viewed: 16 (0 ULg) Uncoupled and coupled hydrogeophysical inversions of seawater intrusion and geothermal hydrologic modelsBeaujean, Jean Doctoral thesis (2015)Most of humans live in coastal and alluvial plains. Sustainable water supply systems are essential for drinking water production while long-term groundwater access ensures its geothermal use. Owing to ... [more ▼]Most of humans live in coastal and alluvial plains. Sustainable water supply systems are essential for drinking water production while long-term groundwater access ensures its geothermal use. Owing to climate change and anthropogenic activities, groundwater resources will be increasingly threatened throughout the twenty-first century. In the context of over-development, any effort to overcome groundwater mining at the expense of better understanding groundwater management problems may be misguided. A combination of robust measuring technologies and reliable predictions based on numerical models are necessary to estimate better hydrogeological parameters. Sparse and continuous data are increasingly being used conjunctively in hydrogeological modeling and inverse calibration to alleviate extrapolation and subjective interpretation. In hydrogeology, electrical resistivity tomography (ERT) gives quantitative and qualitative information on salinity and temperature distribution. ERT offers a means for mapping the subsurface hydrogeological structures and the hydrologic process dynamics in both space and time. The integration of ERT data to hydrogeological calibration is particularly suited to define the hydrogeological models quantitatively and qualitatively. In a deterministic framework, hydrogeophysical inversion methods may be particularly useful for predictive analysis and assessment of groundwater pre-emptive management strategies. This work focuses on calibrating physically-based and spatially distributed groundwater flow and transport models with non-to minimally invasive electrical tomography. The general objective is to provide better estimates of hydrogeological parameters on two relevant problems: seawater intrusion in coastal areas and geothermal energy in shallow environments. We compare methods to integrate quantitatively ERT data, possibly other hydrologic or geological data, with existing information to hydrogeological models. Two hydrogeophysical inversion schemes are developped and a thorough comparison of an uncoupled and a coupled quantitative approach based on the use of surface ERT only is performed. The uncoupled hydrogeophysical inversion involves constraining hydraulic parameters using geophysically-derived data and first requires a geophysical inversion, after which the geophysical parameters are converted to hydrologic data through a petrophysical relationship. The inverse hydrological calibration is then performed on these inferred hydrological data. The coupled hydrogeophysical inversion involves constraining hydraulic parameters using geophysical data through a forward hydrogeophysical model in which the hydrologic data are converted to resistivities through a petrophysical relationship. A geophysical forward problem is then solved for the geophysical data. The inverse hydrological calibration is performed on the inferred geophysical observations. In both schemes, we show that an independent geophysical inversion is required to delineate heterogeneous bodies. In this context, we study how to derive informative content of ERT images and therefore ERTderived hydrologic data and ERT-derived geometry. We show that a quantitative appraisal (the cumulative sensitivity) must be used as a proxy for filtering areas correctly resolved. Our developments are demonstrated on several benchmark SWI models (numerical and analytical), a thermohydrologic model and a field test. We show that the reliability of estimated SWI model parameters with the uncoupled approach depends on ERT image appraisal, on geophysical data collection strategy and hydrogeological model conceptualization. The ERT image appraisal plays a key role in retrieving high quality ERT-derived data and helps discriminate different measurement arrays. It is particularly useful in preventing the integration of noise-related artefacts in the conceptualization. We endeavor to quantify the modeling error by a thorough comparison of different strategies to assess the effect of decreasing model conceptual errors to hydrogeological calibration. In the SWI analytical models, we highlight the subjectivity of the uncoupled approach due to the nature of the required hydrologic data (sharp interface). We demonstrate that the conjunctive use of an image appraisal tool with the well-known Ghyben-Herzberg solution is needed to infer reliable ERT-derived observation data. We further demonstrate that a SWI analytical solution may be used to calibrate an equivalent hydraulic parameter based on an ERT dataset generated from a density-dependent groundwater flow model. In the thermohydrologic model, we show that the effectiveness of the uncoupled scheme in calibrating heat transport parameters may be hampered due to the regularization constraint in the geophysical inversion. We demonstrate the importance of a noise level-related filter on the time-lapse ERT images aimed at properly quantifying the spatio-temporal ERTderived temperature changes. We also advocate the use of a physically-based constraint on the ERT-derived temperatures to account for spatial mixing of waters and to cope indirectly with the smoothing effect in the ERT images. In each application, the coupled approach significantly prevails over the uncoupled scheme in terms of reliability of the parameter estimates when no model conceptual error exists. [less ▲]Detailed reference viewed: 21 (1 ULg) Dispositifs de conservation écorégionale et droits indigènes dans l’Amazonie Bolivienne: Les cas des Peuples du Madidi et Pilón LajasMarquez Guerra, José Francisco Doctoral thesis (2015)The apparatus of conservation at the ecoregional scale integrating natural landscape and cultural landscapes in the Amazon basin has been introduced by international conservation NGOs since the beginning ... [more ▼]The apparatus of conservation at the ecoregional scale integrating natural landscape and cultural landscapes in the Amazon basin has been introduced by international conservation NGOs since the beginning of the 90s when the term hotspot was invented to designate the importance of "mega-diversity "of tropical forests for the survival of humanity. The representation of environmental problems in the Amazon region as serious threats to life on the planet entered the political agenda of the international community becoming a matter of priority attention. To find solutions to this expanding threat, scientists, activists and interested parties have reflected on some formulas, innovative programs and strategies in order that cooperation and international aid could favor the action of effective conservation and sustainable development. The problem of resource degradation of biodiversity, and the loss of the values of cultural diversity of Amazonian peoples is since then conceived as a challenge that goes beyond national political interests, becoming a global issue. Bolivia was a breeding ground for these pioneering efforts, they have made a pragmatic view of international aid with new tools and effective techniques to combat emerging threats, one of them are financial mechanisms for conservation planning. These have entered the Bolivian legal system from the 80 which coincides with the modernization of the state, an ambitious development plan supported by the implementation of neoliberal measures to promote economic growth, administrative decentralization as a new form to exercise power by delegating powers to the departmental and municipal levels, popular participation, as legitimacy methodology, defining local actors and regional planning policy as a useful management of natural resources for sustainable development. International actors of conservation, a group of scientific elite and environmental activists in the country and leaders of local indigenous movements have played an important role before and after this neoliberal modernization in the implementation of an ecorregional conservation apparatus in the Bolivian Amazon. The objective of this transdisciplinaria research, is an ethnographic description, based on the theoretical and methodological repertoire of legal anthropology and sociology of ANT Translation, of how the practices and strategies of conservation at the ecoregional scale through its technical, financial and legal instruments configure the territories, affect social relations and transform representations and practices of the nature of Amazonian peoples Mosetene, Tsimane' Tacana, Quechua-Tacana and Leco. The traditional spaces of these peoples are in total or partially overlapping with the current Natural Park and Integrated Management Area Madidi and Biosphere Reserve and Indigenous Territory Pilón Lajas implemented as protected areas during the 90 In this context, challenges and current controversies looming over the planning and use of space at different scales between actors of the policies of sustainable development and conservation, local political elites and indigenous peoples. [less ▲]Detailed reference viewed: 38 (15 ULg) Multitasking abilities in persons diagnosed with schizophrenia: a new tool and cognitive model.Laloyaux, Julien ; Van der Linden, Martial ; Laroi, Frank Poster (2015, April 01)Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia, and in particular during multitasking activities (Semkovska et al., 2010). Multitasking refers to ... [more ▼]Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia, and in particular during multitasking activities (Semkovska et al., 2010). Multitasking refers to activities (e.g. preparing a meal) where the person has to: (a) carry out and alternate between different tasks that vary in terms of priority, difficulty and duration; (b) define the tasks’ targets; (c) and where the person is faced with unexpected problems during the realization of these tasks (Burgess, 2000). However, the cognitive underpinnings of multitasking abilities have never been adequately explored in schizophrenia. Further, only two cognitive models exist in the literature, which are based on student (Logie et al., 2011) and neurological (Burgess et al., 2000) samples. Both of these models suggest three primary constructs: Memory, Planning and Intent. There are, however, several limitations related to the way multitasking abilities were evaluated in these studies. We thus developed a computerized real-life activity task - the Computerized Meeting Preparation Task (CPMT), which was specifically designed to take into account the multitasking nature of certain everyday life activities. Using this task, and based on previous studies (Burgess et al., 2000; Logie et al., 2011), the aim of the present study was to evaluate multitasking abilities in schizophrenia and to do so in a new cognitive model of multitasking that takes into account certain cognitive functions that are not integrated in existing models. Methods: Fifty-seven individuals with schizophrenia and 41 matched healthy controls completed the CMPT. Participants were also evaluated with a battery of cognitive tests. Results: The results suggest that the CMPT possesses good sensitivity and confirmed the three underlying constructs of multitasking (Memory, Planning and Intent), which were found to be underpinned by several cognitive functions and multitasking aspects. Conclusion: Taken together, this new cognitive model and the CMPT could be a good basis for cognitive interventions of multitasking abilities in schizophrenia. Burgess, P.W., 2000. Strategy application disorder: the role of the frontal lobes in human multitasking. Psychol Res 63, 279-288. Logie, R., et al., 2011. Multitasking: multiple, domain-specific cognitive functions in a virtual environment. Mem Cogn 39, 1561-1574. Semkovska, M. et al., 2004. Assessment of executive dysfunction during activities of daily living in schizophrenia. Schizophr Res 69, 289-300. [less ▲]Detailed reference viewed: 21 (4 ULg) Literature Review Analysis on Energy Performance and Sustainable Buildings in RomaniaAna Mureșan, Adina; Attia, Shady Report (2015)This work is a part of the Master of Science Thesis written during the mobility organized by the Erasmus + Programme for exchange students at Universite de Liege, in Belgium (Université de Liège, Belgique ... [more ▼]This work is a part of the Master of Science Thesis written during the mobility organized by the Erasmus + Programme for exchange students at Universite de Liege, in Belgium (Université de Liège, Belgique), which is in bilateral agreement with Technical University of Cluj-Napoca, in Romania (Universitatea Tehnică din Cluj-Napoca, România) available between 2014 – 2020. The audience of this literature review is civil engineers and specialists in building energy and it aims to inform about the current state-of-the-art of the sustainable buildings design and energy performance in the Romanian context. The work presents the review of 35 publications chosen from the Literature Survey List which includes 80 publications. The publications included in the Literature Survey List are Romanian standards for energy performance in buildings, chapters from books and journal articles. The sources of the publications are included in the Resources Screening List. [less ▲]Detailed reference viewed: 11 (1 ULg) La narration en gravure et en bande dessinéePaques, Frédéric ; Pinelli, Joe; Hardy, ChantalConference given outside the academic context (2015)Cette tale ronde réunissait trois graveurs ayant la narration comme préoccupation première dans leur travail : Jean-Christophe Long, Thierry Lenoir et Sylvain BureauDetailed reference viewed: 15 (0 ULg) The K2-ESPRINT Project I: Discovery of the Disintegrating Rocky Planet with a Cometary Head and Tail EPIC 201637175bSanchis-Ojeda, R.; Rappaport, S.; Pallé, E. et alE-print/Working paper (2015)We present the discovery of a transiting exoplanet candidate in the K2 Field-1 with an orbital period of 9.1457 hours: EPIC 201637175b. The highly variable transit depths, ranging from $\sim$0\% to 1.3 ... [more ▼]We present the discovery of a transiting exoplanet candidate in the K2 Field-1 with an orbital period of 9.1457 hours: EPIC 201637175b. The highly variable transit depths, ranging from $\sim$0\% to 1.3\%, are suggestive of a planet that is disintegrating via the emission of dusty effluents. We characterize the host star as an M-dwarf with $T_{\rm eff} \simeq 3800$. We have obtained ground-based transit measurements with several 1-m class telescopes and with the GTC. These observations (1) improve the transit ephemeris; (2) confirm the variable nature of the transit depths; (3) indicate variations in the transit shapes; and (4) demonstrate clearly that at least on one occasion the transit depths were significantly wavelength dependent. The latter three effects tend to indicate extinction of starlight by dust rather than by any combination of solid bodies. The K2 observations yield a folded light curve with lower time resolution but with substantially better statistical precision compared with the ground-based observations. We detect a significant bump' just after the transit egress, and a less significant bump just prior to transit ingress. We interpret these bumps in the context of a planet that is not only likely streaming a dust tail behind it, but also has a more prominent leading dust trail that precedes it. This effect is modeled in terms of dust grains that can escape to beyond the planet's Hill sphere and effectively undergo `Roche lobe overflow', even though the planet's surface is likely underfilling its Roche lobe by a factor of 2. [less ▲]Detailed reference viewed: 20 (3 ULg) Efficacy of heroin-assisted treatment in Belgium: a randomised controlled trialDemaret, Isabelle ; Quertemont, Etienne ; Litran, Géraldine et alin European Addiction Research (2015), 21(4), 179-187Background/Aims: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts still using street heroin after a methadone treatment. In Belgium, a new trial compared the efficacy of a HAT ... [more ▼]Background/Aims: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts still using street heroin after a methadone treatment. In Belgium, a new trial compared the efficacy of a HAT to existing methadone maintenance treatment. Methods: In this randomised controlled trial, HAT was limited to 12 months. Participants were assessed every 3 months. They were responders if they showed improvement on the level of street heroin use, health or criminal involvement. Results: 74 participants were randomised in the trial. The experimental group (n=36) counted 30% of responders more than the control group (n=38) at each assessment point (p<0.05), except at 12 months where the difference (11%) was no longer significant (p=0.35). Still, after 12 months, participants in the experimental group reported significantly greater improvements (p<0.05) than the control group on the level of street heroin use and on the level of physical and mental health. Both groups reported significantly less criminal facts after 12 months (p<0.001), but with no significant difference between the groups. Conclusions: This trial confirms the short-term efficacy of HAT for severe heroin addicts, who already failed methadone treatment. [less ▲]Detailed reference viewed: 56 (17 ULg) Wolff’s Law and the Interplay between Bone Structure and External LoadingRuffoni, Davide ; Christen, Patrik; Scherf, Heike et alin IBMS BoneKEy (2015, April), 13Detailed reference viewed: 20 (7 ULg)