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Middle Palaeolithic Blade Industries and Early Upper Palaeolithic with Carinated Bladelet Cores: New Data from Kulbulak (Uzbekistan)Flas, Damien ; ; et alConference (2013) Detailed reference viewed: 2 (0 ULg) The evaluation of singing voice accuracy: A comparison between subjective and objective methodsLarrouy, Pauline ; ; et alin Journal of Voice (2013), 27(2), 2591-5 Objective: Vocal accuracy of a sung performance can be evaluated by two methods: acoustic analyses and subjective judgements. Acoustic analyses have been presented as a more reliable solution but both ... [more ▼] Objective: Vocal accuracy of a sung performance can be evaluated by two methods: acoustic analyses and subjective judgements. Acoustic analyses have been presented as a more reliable solution but both methods are still used for the evaluation of singing voice accuracy. This paper presents a first time direct comparison of these methods. Methods: 166 untrained singers were asked to sing the popular song « Happy Birthday ». These recordings constituted the database analyzed. Acoustic analyses were performed to quantify the pitch interval deviation, the number of contour errors and the number of tonality modulations for each recording. Additionally, eighteen experts in singing voice or music rated the global pitch accuracy of these performances. Results: A high correlation occurred between acoustic measurements and subjective rating. The total model of acoustic analyses explained 81% of the variance of the judges’ scores. Their rating was influenced by both tonality modulation and interval deviation. Conclusions: This study highlights the congruence between objective and subjective measurements of vocal accuracy within this first time comparison. Our results confirm the relevance of the pitch interval deviation criterion in vocal accuracy assessment. Furthermore, the number of tonality modulations is also a salient criterion in perceptive rating and should be taken into account in studies using acoustic analyses. [less ▲] Detailed reference viewed: 35 (14 ULg) Peptidoglycan glycosyltransferase substrate mimics as templates for the design of new antibacterial drugs.Derouaux, Adeline ; Sauvage, Eric ; Terrak, Mohammed ![]() in Frontiers in immunology (2013), 4 Peptidoglycan (PG) is an essential net-like macromolecule that surrounds bacteria, gives them their shape, and protects them against their own high osmotic pressure. PG synthesis inhibition leads to ... [more ▼] Peptidoglycan (PG) is an essential net-like macromolecule that surrounds bacteria, gives them their shape, and protects them against their own high osmotic pressure. PG synthesis inhibition leads to bacterial cell lysis, making it an important target for many antibiotics. The final two reactions in PG synthesis are performed by penicillin-binding proteins (PBPs). Their glycosyltransferase (GT) activity uses the lipid II precursor to synthesize glycan chains and their transpeptidase (TP) activity catalyzes the cross-linking of two glycan chains via the peptide side chains. Inhibition of either of these two reactions leads to bacterial cell death. beta-lactam antibiotics target the transpeptidation reaction while antibiotic therapy based on inhibition of the GTs remains to be developed. Ongoing research is trying to fill this gap by studying the interactions of GTs with inhibitors and substrate mimics and utilizing the latter as templates for the design of new antibiotics. In this review we present an updated overview on the GTs and describe the structure-activity relationship of recently developed synthetic ligands. [less ▲] Detailed reference viewed: 5 (3 ULg) The first Upper Paleolithic human remains from Belgium: Aurignacian, Gravettian and Magdalenian fossils at the “troisième caverne” of Goyet; ; et al Poster (2013) Detailed reference viewed: 7 (0 ULg) L’appropriation discursive et pratique du concept de développement durable par des GACEURS et des bénévoles/travailleurs du commerce équitable, vers un imaginaire critique partagé ?Thys, Séverine ![]() E-print/Working paper (2013) Ce Working Paper interroge l’existence d’un référentiel critique et argumentatif commun à des initiatives d’Economie Sociale du secteur alimentaire. En utilisant l’appareillage théorique de la « ... [more ▼] Ce Working Paper interroge l’existence d’un référentiel critique et argumentatif commun à des initiatives d’Economie Sociale du secteur alimentaire. En utilisant l’appareillage théorique de la « sociologie des épreuves », les propos de GACEURS et de bénévoles/salariés du commerce équitable sont analysés afin de voir si le concept de Développement Durable porte en lui un projet sociétal, un référentiel fédérateur, apte à mobiliser des consom’acteurs autour de revendications partagées. L’analyse met en évidence un corpus critique commun articulé autour de quatre axes, dont trois relèvent bien du développement durable, mais nuance ses conclusions au vu de la faiblesse de la grammaire argumentative construite, et des contradictions qui la parcourent. [less ▲] Detailed reference viewed: 7 (2 ULg) Hydrological and geopedological dynamics of a forested slopeDeraedt, Deborah ; Degré, Aurore ; Colinet, Gilles ![]() in Geophysical Research Abstracts (2013), 15 Though forested watersheds are really particular in terms of hydrodynamics, most of the hydrological models oversimplify the phenomena involved. More investigations are unavoidable to improve the ... [more ▼] Though forested watersheds are really particular in terms of hydrodynamics, most of the hydrological models oversimplify the phenomena involved. More investigations are unavoidable to improve the knowledge and the modelling of this environment. Here is the aim of this study. The studied slope is located on the Houille watershed in the West of the Belgian Ardenne (50 1’47”N, 4 53’22”E) on a silty rocky soil. The site is situated under a Douglas fir (Pseudotsuga menziesii (MIRB.) FRANCO) and spruce stand cover (Picea abies (L.) Karst). It is about 160 meters long with a North-West facing slope between 7 and 55%. The goal of the study is : - to characterise the hydrological and pedogeological dynamics along a forested slope, - to compare these dynamics with the tree growth. For the geopedological part of the study, eight pits were dug to describe the soil and take some soil samples used for granulometric, chemical, etc. analysis. We have used geophysical methods (Electrical Resistivity Tomography and Ground Penetrating Radar) to estimate the soil depth. As for the hydrological part of this study, moisture sensors (capacitive and TDR) have been installed in the pits along the slope. A dye tracing test has been performed to underline the preferential flow and the importance of the subsurface flow. Several trees have been equipped with dendrometers and some measures of the LAI and the height of the trees are planned. [less ▲] Detailed reference viewed: 21 (5 ULg) Electrochemical and PM-IRRAS characterization of cholera toxin binding at a model biological membrane.; ; et al in Langmuir : the ACS journal of surfaces and colloids (2013), 29(3), 965-76 A mixed phospholipid-cholestrol bilayer, with cholera toxin B (CTB) units attached to the monosialotetrahexosylganglioside (GM1) binding sites in the distal leaflet, was deposited on a Au(111) electrode ... [more ▼] A mixed phospholipid-cholestrol bilayer, with cholera toxin B (CTB) units attached to the monosialotetrahexosylganglioside (GM1) binding sites in the distal leaflet, was deposited on a Au(111) electrode surface. Polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) measurements were used to characterize structural and orientational changes in this model biological membrane upon binding CTB and the application of the electrode potential. The data presented in this article show that binding cholera toxin to the membrane leads to an overall increase in the tilt angle of the fatty acid chains; however, the conformation of the bilayer remains relatively constant as indicated by the small decrease in the total number of gauche conformers of acyl tails. In addition, the bound toxin caused a significant decrease in the hydration of the ester group contained within the lipid bilayer. Furthermore, changes in the applied potential had a minimal effect on the overall structure of the membrane. In contrast, our results showed significant voltage-dependent changes in the average orientation of the protein alpha-helices that may correspond to the voltage-gated opening and closing of the central pore that resides within the B subunit of cholera toxin. [less ▲] Detailed reference viewed: 6 (1 ULg) Une note sur Ipouer XII, 13-14Winand, Jean ![]() in Zeitschrift für Agyptische Sprache und Altertumskunde (2013) Detailed reference viewed: 20 (2 ULg) Influence of processing parameters on physicochemical properties of low-trans and trans-free puff pastry margarinesLefebure, Emilie ; ; Brostaux, Yves et alin LWT - Food Science and Technology (2013), 51(1), 225-232 Detailed reference viewed: 26 (16 ULg) Knowledge without Judgement: Lotze, Brentano, and Cook WilsonBoccaccini, Federico ![]() Conference (2013) Detailed reference viewed: 2 (0 ULg) Parathormone and bone-specific alkaline phosphatase for the follow-up of bone turnover in hemodialysis patients : Is it so simple?DELANAYE, Pierre ; DUBOIS, Bernard ; JOURET, François et alin Clinica Chimica Acta (2013), 417 Background: Chronic Kidney Disease (CKD) is associated with mineral and bone disorders (MBD). International guidelines suggest that levels of serum parathormone (PTH) or bone-specific alkaline phosphatase ... [more ▼] Background: Chronic Kidney Disease (CKD) is associated with mineral and bone disorders (MBD). International guidelines suggest that levels of serum parathormone (PTH) or bone-specific alkaline phosphatase (b-ALP) can be used to evaluate MBD in dialysis patients. The evidence remains moderate and based on transversal studies. <br />Methods: We retrospectively investigated the variations of PTH (ΔPTH) and b-ALP (Δb-ALP) serum concentrations over a short (6-weeks) and a long (one-year) period in a monocentric hemodialysis population. The proportion of patients reaching the critical difference (CD) (50% for PTH and 25% for b-ALP) was calculated. <br />Results: Seventy-seven patientswere included. A significant correlation between PTHand b-ALP levelswas found at baseline (r=0.51). By contrast, no correlation was observed between ΔPTH and Δb-ALP over a 6-week interval (r=0.07). The CD for PTH and b-ALP was reached by 19 and 11 patients, respectively, with 2 patients showing consistent variations of both biomarkers. One year later, measurements were repeated in 48 survivors. <br />No correlation was found between ΔPTH and Δb-ALP (r=0.27). The CD for PTH or b-ALP was reached by 24 patients and 28 patients, respectively, with 6 patients (12.5%) showing opposite results for both biomarkers. <br />Conclusion: This study shows the lack of correlation between ΔPTH and Δb-ALP over time in patients under chronic hemodialysis. [less ▲] Detailed reference viewed: 27 (13 ULg) Our rapidly changing understanding of acute and chronic disorders of consciousness: challenges for neurologistsGantner, Sylvia ; BODART, Olivier ; Laureys, Steven et alin Future Neurology (2013), 8(1), 43-54 A number of recent studies suggest that some ‘vegetative state’ patients have been misdiagnosed, judging by their ability to follow commands and in some cases even communicate through brain activity. Such ... [more ▼] A number of recent studies suggest that some ‘vegetative state’ patients have been misdiagnosed, judging by their ability to follow commands and in some cases even communicate through brain activity. Such studies highlight the difficulty in forming a diagnosis based only on behavioral assessments. We think that neuroimaging and electrophysiology methods will be used more frequently in clinical settings, integrated with existing behavioral assessments. Such efforts are expected to lead to a more accurate understanding of individual patients’ cognitive abilities or even provide prognostic indicators. In terms of treatment planning (i.e., pain management and end-of-life decision-making), patients with disorders of consciousness are now offered the possibility of expressing their preferences by means of brain–computer interfaces. What remains to be clarified is the degree to which such indirect responses can be considered reliable and of legal representation. [less ▲] Detailed reference viewed: 69 (0 ULg) Erscheinungsformen rheinischer Alltagssprache. Untersuchungen zu Variation und Kookkurrenzregularitäten im "mittleren Bereich" zwischen Dialekt und StandardspracheMöller, Robert ![]() Book published by Steiner (2013) Detailed reference viewed: 19 (0 ULg) Les négociations internationales sur le climat, une histoire sans fin ?Gemenne, François ![]() in Petiteville, Franck; Placidi, Delphine (Eds.) Négociations Internationales. (2013) Detailed reference viewed: 5 (0 ULg) METHis VI. Images fixes / Images en mouvementBert, Mathilde ; Falque, Ingrid ; Hagelstein, Maud ![]() Book published by Presses Universitaires de Liège (2013) Detailed reference viewed: 19 (4 ULg) Influence of monopalmitin on the isothermal crystallization mechanism of palm oil; Danthine, Sabine ; Blecker, Christophe et alin Food Research International (2013), 51(1), 344-353 Detailed reference viewed: 8 (0 ULg) Parameterization of the proline analogue Aze (azetidine-2-carboxylic acid) for molecular dynamics simulations and evaluation of its effect on homo-pentapeptide conformations.Bessonov, Kyrylo ; ; in Journal of Molecular Graphics and Modelling (2013), 39 We have parameterized and evaluated the proline homologue Aze (azetidine-2-carboxylic acid) for the gromos56a3 force-field for use in molecular dynamics simulations using GROMACS. Using bi-phasic ... [more ▼] We have parameterized and evaluated the proline homologue Aze (azetidine-2-carboxylic acid) for the gromos56a3 force-field for use in molecular dynamics simulations using GROMACS. Using bi-phasic cyclohexane/water simulation systems and homo-pentapeptides, we measured the Aze solute interaction potential energies, ability to hydrogen bond with water, and overall compaction, for comparison to Pro, Gly, and Lys. Compared to Pro, Aze has a slightly higher H-bonding potential, and stronger electrostatic but weaker non-electrostatic interactions with water. The 20-ns simulations revealed the preferential positioning of Aze and Pro at the interface of the water and cyclohexane layers, with Aze spending more time in the aqueous layer. We also demonstrated through simulations of the homo-pentapeptides that Aze has a greater propensity than Pro to undergo trans-->cis peptide bond isomerization, which results in a severe 180 degrees bend in the polypeptide chain. The results provide evidence for the hypothesis that the misincorporation of Aze within proline-rich regions of proteins could disrupt the formation of poly-proline type II structures and compromise events such as recognition and binding by SH3-domains. [less ▲] Detailed reference viewed: 1 (1 ULg) Benzene dynamics and biodegradation in alluvial aquifers affected by river fluctuations; ; et al in Ground Water (2013) The spatial distribution and temporal dynamics of a benzene plume in an alluvial aquifer strongly affected by river fluctuations was studied. Benzene concentrations, aquifer geochemistry datasets, past ... [more ▼] The spatial distribution and temporal dynamics of a benzene plume in an alluvial aquifer strongly affected by river fluctuations was studied. Benzene concentrations, aquifer geochemistry datasets, past river morphology and benzene degradation rates estimated in situ using stable carbon isotope enrichment were analysed in concert with aquifer heterogeneity and river fluctuations. Geochemistry data demonstrated that benzene biodegradation was on-going under sulphate reducing conditions. Long-term monitoring of hydraulic heads and characterisation of the alluvial aquifer formed the basis of a detailed modelled image of aquifer heterogeneity. Hydraulic conductivity was found to strongly correlate with benzene degradation, indicating that low hydraulic conductivity areas are capable of sustaining benzene anaerobic biodegradation provided the electron acceptor (SO42-) does not become rate limiting. Modelling results demonstrated that the groundwater flux direction is reversed on annual basis when the river level rises up to two meters, thereby forcing the infiltration of oxygenated surface water into the aquifer. The mobilisation state of metal trace elements such as Zn, Cd and As present in the aquifer predominantly depended on the strong potential gradient within the plume. However, infiltration of oxygenated water was found to trigger a change from strongly reducing to oxic conditions near the river, causing mobilisation of previously immobile metal species and vice versa. Monitored natural attenuation appears to be an appropriate remediation strategy in this type of dynamic environment provided that aquifer characterisation and targeted monitoring of redox conditions is adequate and electron acceptors remain available until concentrations of toxic compounds reduce to acceptable levels. [less ▲] Detailed reference viewed: 2 (0 ULg) Frequency-domain subspace identification of nonlinear mechanical systems - Application to a solar array structureNoël, Jean-Philippe ; Kerschen, Gaëtan ; et alin Proceedings of the International Modal Analysis Conference (IMAC) XXXI (2013) The present paper addresses the experimental identification of a simplified realisation of a solar array structure in folded configuration. To this end, a nonlinear subspace identification technique ... [more ▼] The present paper addresses the experimental identification of a simplified realisation of a solar array structure in folded configuration. To this end, a nonlinear subspace identification technique formulated in the frequency domain, referred to as the FNSI method, is exploited. The frequency response functions of the underlying linear structure and the nonlinear coefficients are estimated by this approach. Nonlinearity is caused by impacts between adjacent panels and friction and gaps appearing in their clamping interfaces. This application is challenging for several reasons, which include high modal density and the complicated nature of the involved nonlinear mechanisms. [less ▲] Detailed reference viewed: 33 (3 ULg) |
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