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See detailEffects of adenosine on lymphangiogenesis.
Lenoir, Bénédicte ULg; Wagner, Daniel R.; Blacher, Silvia ULg et al

in PloS one (2014), 9(3), 92715

BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood ... [more ▼]

BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood but promotes tumor spread and metastasis during adulthood. Blocking lymphangiogenesis may therefore be of therapeutic interest. Production of adenosine is enhanced in the tumor environment and contributes to tumor progression through stimulation of angiogenesis. In this study, we determined whether adenosine affects lymphangiogenesis. METHODS: Lymphatic endothelial cells (HMVEC-dLy) were cultured in presence of adenosine and their proliferation, migration and tube formation was assessed. Gelatin sponges embedded with the stable analogue of adenosine 2-chloro adenosine were implanted in mice ear and lymphangiogenesis was quantified. Mice were intravenously injected with adenoviruses containing expression vector for 5'-endonucleotidase, which plays a major role in the formation of adenosine. RESULTS: In vitro, we observed that adenosine decreased the proliferation of lymphatic endothelial cells, their migration and tube formation. However, in vivo, gelatin sponges containing 2-chloro adenosine and implanted in mice ear displayed an elevated level of lymphangiogenesis (2.5-fold, p<0.001). Adenovirus-mediated over-expression of cytosolic 5'-nucleotidase IA stimulated lymphangiogenesis and the recruitment of macrophages in mouse liver. Proliferation of lymphatic endothelial cells was enhanced (2-fold, p<0.001) when incubated in the presence of conditioned medium from murine macrophages. CONCLUSION: We have shown that adenosine stimulates lymphangiogenesis in vivo, presumably through a macrophage-mediated mechanism. This observation suggests that blockade of adenosine receptors may help in anti-cancer therapies. [less ▲]

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See detailValidity and Reliability of the French version of the STarT Back Screening Tool for patients with low back pain.
Bruyère, Olivier ULg; Demoulin, Maryline; Beaudart, Charlotte ULg et al

in Spine (2014), 39(2), 123-128

Study Design. Observational prospective study.Objective. Our objective was to assess the reliability and validity of the French version of the Keele STarT Back Screening Tool (SBST).Summary of Background ... [more ▼]

Study Design. Observational prospective study.Objective. Our objective was to assess the reliability and validity of the French version of the Keele STarT Back Screening Tool (SBST).Summary of Background Data. The SBST is a recently validated tool developed to identify subgroups of patients with low back pain (LBP) to guide early secondary prevention in primary care.Methods. Outpatients with LBP aged 18 years or more, attending a rehabilitation centre, a back school, a private physiotherapy unit or a fitness centre were included. Patients were assessed through the SBST, Roland-Morris Disability Questionnaire (RMDQ), Orebro Musculoskeletal Pain Screening Questionnaire (OMPSQ), Medical Outcomes Survey Short Form 36 (SF-36) questionnaire, and a pain visual analogic scale (VAS). Test-retest reliability was assessed with Kappa score or the intraclass correlation coefficient (ICC), internal consistency of the psychological subscale with the Cronbach alpha coefficient, construct validity with the Spearman's correlation coefficient, and floor and ceiling effects by percentage frequency of lowest or highest possible score achieved by respondents.Results. 108 patients with LBP were included. The test-retest reliability of the SBST total score was excellent with an ICC of 0.90 (0.81-0.95). The Cronbach alpha coefficient was 0.73 showing a good internal consistency for the psychological subscale. High Spearman's correlation coefficients of 0.74 between SBST and RMDQ, and 0.74 between the SBST and OMPSQ were observed. As expected, low to moderate correlations were observed between the SBST total score and some dissimilar measures of the SF-36. The lowest possible SBST score was observed for 8 patients (7.4%) whereas only three patients (2.8%) had the highest possible SBST score.Conclusion. The French version of the SBST is a reliable and valid questionnaire consistent with the original English version. Therefore, this new version may help French-speaking clinicians and scientists to stratify patients with LBP. [less ▲]

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See detailRobot-assisted laparoscopy for deep infiltrating endometriosis: international multicentric retrospective study.
Collinet, Pierre; Leguevaque, Pierre; Neme, Rosa Maria et al

in Surgical Endoscopy (2014), sous presse

BACKGROUND: This study aimed to assess the interest in robot-assisted laparoscopy for deep infiltrating endometriosis and to investigate the perioperative results. METHODS: From November 2008 to April ... [more ▼]

BACKGROUND: This study aimed to assess the interest in robot-assisted laparoscopy for deep infiltrating endometriosis and to investigate the perioperative results. METHODS: From November 2008 to April 2012, 164 women with stage 4 endometriosis who underwent robot-assisted laparoscopy (da Vinci Intuitive Surgical System) were included by to eight international participating clinical centers. This study evaluated the procedures performed, the duration of the intervention, the complications, the recurrence, and the impact on fertility. RESULTS: The average operative time was 180 min. The main complications were laparotomy (n = 1, 0.6 %), sutured bowel injury (n = 2, 1.2 %), transfusion for a 2,300-ml bleed (n = 1), prolonged urinary catheterization (n = 1, 0.6 %), ureter-bladder anastomotic leak (n = 1, 0.6 %), and ureteral fistula after ureterolysis (n = 2, 1.2 %). The reoperation rate was 1.8 % (n = 3). The mean follow-up period was 10.2 months. A full recovery was experienced by 86.7 % (98/113) of the patients. After surgery, 41.2 % (42/102) of the patients had a desire for pregnancy, and 28.2 % (11/39) of them became pregnant. CONCLUSION: This study analyzed the largest series of robot-assisted laparoscopies for deep infiltrating endometriosis published in the literature. No increase in surgical time, blood loss, or intra- or postoperative complications was observed. The interest in robot-assisted laparoscopy for deep infiltrating endometriosis seems to be promising. [less ▲]

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See detail"Je n'aime pas mon accent américaine": quelle culture discursive pour quelle conscience normative chez les étudiants Erasmus?
Meunier, Deborah ULg

in Dervin, Fred; Machart, Régis (Eds.) Les nouveaux enjeux des mobilités et migrations académiques (2014)

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See detailTRAITEMENT CONSERVATEUR DES CANCERS INFILTRANTS DE LA VESSIE
WERENNE, Xavier ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 69-74

Le cancer de la vessie occupe la 9ème place en termes de fréquence, voire la 2 ème chez la personne âgée, et se situe juste après celui de la prostate. La cystectomie est actuelle- ment le traitement ... [more ▼]

Le cancer de la vessie occupe la 9ème place en termes de fréquence, voire la 2 ème chez la personne âgée, et se situe juste après celui de la prostate. La cystectomie est actuelle- ment le traitement «standard» des cancers infiltrants de la vessie. Cependant, elle est liée à un taux élevé de complications et à une altération de la qualité de vie, en particulier, chez les patients âgés présentant de nombreuses comorbidités. Le but de cet article est de déterminer les alternatives conservatrices et de préciser à quels patients elles doivent être réservées, en particulier, l’approche trimodale (résection trans-uréthrale et radio-chimiothérapie) et la cystectomie partielle précédée de radio-chimiothérapie [less ▲]

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See detailÉDITORIAL : Augmenter la visibilité de la radiothérapie
COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 1-2

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See detailLa primauté de l'intentionnalité et ses conséquences épistémologiques
Boccaccini, Federico ULg

in Bulletin d'Analyse Phénoménologique (2014)

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See detailAnalysis of collagen preservation in bones recovered in archaeological contexts using NIR Hyperspectral Imaging
Vincke, Damien; Miller, Rebecca ULg; Stassart, Edith ULg et al

in Talanta (2014), 125

The scope of this article is to propose an innovative method based on Near Infrared Hyperspectral Chemical Imaging (NIR-HCI) to rapidly and non-destructively evaluate the relative degree of collagen ... [more ▼]

The scope of this article is to propose an innovative method based on Near Infrared Hyperspectral Chemical Imaging (NIR-HCI) to rapidly and non-destructively evaluate the relative degree of collagen preservation in bones recovered from archaeological contexts. This preliminary study has allowed the evaluation of the potential of the method using bone samples from the Early Upper Palaeolithic, Mesolithic and Neolithic periods at the site of Trou Al'Wesse in Belgium. NIR-HCI, combined with chemometric tools, has identified specific spectral bands characteristic of collagen. A chemometric model has been built using Partial Least Squares Discriminant Analysis (PLS-DA) to identify bones with and without collagen. This enables the evaluation of the degree of collagen preservation and homogeneity in bones within and between different strata, which has direct implications for archaeological applications (e.g., taphonomic analyses, assemblage integrity) and sample selection for sub- sequent analyses requiring collagen. Two archaeological applications are presented: comparison between sub-layers in an Early Upper Palaeolithic unit, and evaluation of the range of variability in collagen preservation within a single Holocene stratum. [less ▲]

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See detailMonitoring batch lipase catalyzed interesterification of palm oil and fractions by differential scanning calorimetry
Danthine, Sabine ULg; DeClercq, Nathalie; Dewettinck, Koen et al

in Journal of Thermal Analysis and Calorimetry (2014)

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See detailLA PHYSIQUE DES RADIATIONS IONISANTES POUR LES NEOPHYTES
LENAERTS, Eric ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 13-15

Le développement clinique, à visée diagnostique et thérapeutique, des radiations ionisantes a nécessité une com - préhension de la physique. L’exploitation de ces connaissances a mené à des progrès ... [more ▼]

Le développement clinique, à visée diagnostique et thérapeutique, des radiations ionisantes a nécessité une com - préhension de la physique. L’exploitation de ces connaissances a mené à des progrès majeurs en radiothérapie, visant à l’op - timisation de la distribution de la dose sur la cible et à l’exclu - sion, dans la mesure du possible, de l’irradiation des tissus sains avoisinants. Le développement de nouvelles modalités de traitement, telle l’utilisation des hadrons, est le reflet du développement de cette science. Aux confins de cette radio- physique se trouve la radiobiologie, et l’ensemble des connais - sances dans ces deux domaines permet une optimisation de la prescription médicale [less ▲]

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See detailLA RADIOBIOLOGIE POUR LES NÉOPHYTES
COUCKE, Philippe ULg; MARTINIVE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 16-19

La radiothérapie moderne ne se base pas unique - ment sur l’exploitation des améliorations en informatique, imagerie et robotique. La meilleure distribution de la dose au niveau de la cible, avec ... [more ▼]

La radiothérapie moderne ne se base pas unique - ment sur l’exploitation des améliorations en informatique, imagerie et robotique. La meilleure distribution de la dose au niveau de la cible, avec l’épargne des tissus sains avoisinants, rend possible une nouvelle exploitation de concept de radio - biologie. L’exemple type est la redécouverte des traitements hypo-fractionnés. [less ▲]

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See detailDensity estimates and nesting-site selection in chimpanzees of the Nimba Mountains, Côte d'Ivoire and Guinea
Granier, Nicolas ULg; Hambuckers, Alain ULg; Matsuzawa et al

in American Journal of Primatology (2014)

We investigated nesting behavior of non habituated chimpanzees populating the Nimba Mountains to document their abundance and their criterions of nesting-site selection. During a 19-month study we walked ... [more ▼]

We investigated nesting behavior of non habituated chimpanzees populating the Nimba Mountains to document their abundance and their criterions of nesting-site selection. During a 19-month study we walked 80 km of transects and recces each month, and recorded 764 nests (mean group size = 2.23 nests) along with characteristics of vegetation structure and composition, topography and seasonality. Population density estimated with two nest count methods ranged between 0.14 and 0.65 chimpanzee/km2. These values are lower than previous estimates, emphasizing the necessity of protecting remaining wild ape populations. Chimpanzees built nests in 108 tree species out of 437 identified, but 2.3% of total species comprised 52% of nests. Despite they preferred nesting in trees of 25-29 cm DBH and at a mean height of 8.02 m, we recorded an important proportion of terrestrial nests (8.2%) that may reflect a cultural trait of Nimba chimpanzees. A logistic model of nest presence formulated as a function of 12 habitat variables revealed preference for gallery and mountain forests rather than lowland forest, and old-growth forest rather than secondary forests. They nested more frequently in the study area during the dry season (December-April). The highest probability of observing nests was at 770 m altitude, particularly in steep locations (mean ground declivity = 15.54%). Several of the reported nest characteristics combined with the existence of 2 geographically separated clusters of nest, suggest that the study area constitutes the non-overlapping peripheral areas of 2 distinct communities. This nest-based study led us to findings on the behavioral ecology of Nimba chimpanzees, which constitute crucial knowledge to implement efficient and purpose-built conservation. [less ▲]

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See detailLe traitement multidisciplinaire du glioblastome
BARTHELEMY, Nicole ULg; GENNIGENS, Christine ULg; Scholtes, Félix ULg et al

in Revue Médicale de Liège (2014), 69

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See detailQuand le savoir s'emmêle... La construction discursive de la norme chez les locuteurs non experts
Meunier, Deborah ULg; Rosier, Laurence

in Carnets du Cediscor (2014), 12

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See detailUn véhicule pour son enfant, mais une assurance à quel prix ?
Paris, Catherine ULg

in Recueil de Jurisprudence Responsabilité - Assurances - Accidents du travail, Vol. II - Jurisprudence 2012 (2014)

L'auteur examine la sanction qu'encourt le preneur d'assurance qui ne déclare pas correctement le risque au moment de conclure le contrat dans le but de faire une économie de prime.

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See detailLa recette commentée sur la toile: un genre renouvelé?
Meunier, Deborah ULg; Rosier, Laurence

in Arena Romanistica (2014), 14

The principle of procedurality, as well as the practice of transmission, define culinary discourse in the form of recipes, a sub-genre of emblematic discourse. Electronic tools have permitted a renewal of ... [more ▼]

The principle of procedurality, as well as the practice of transmission, define culinary discourse in the form of recipes, a sub-genre of emblematic discourse. Electronic tools have permitted a renewal of the recipe’s very form, which was initially a case of linear transmission in a chronological sense, towards a dialogal and polyphonic form in which the original posted recipe becomes recipe only when it is enlivened with commentaries which complete and perform it. Our contribution aims to show this discursive co-construction. From the point of view of genres, we will also see that those genres which are known as monologal or fixed can evolve towards dialogal and dialogical forms. [less ▲]

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See detailL'évaluation des compétences en salle de classe : régulations entre politiques et pratiques
Laveault, Dany; Dionne, Eric; Lafontaine, Dominique ULg et al

in Dierendonck, Christophe; Loarer, Even; Rey, Bernard (Eds.) L'évaluation des compétences en milieu scolaire et en milieu professionnel (2014)

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See detailCharacterization of multi-walled carbon nanotube dispersion in resorcinol-formaldehyde aerogel
Haghgoo, Majid; Yousefi, Ali Akbar; Zohouriaan Mehr, Mohammad Jalal et al

in Microporous & Mesoporous Materials (2014), 184

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See detailPt/C catalyst for PEM fuel cells: Control of Pt nanoparticles characteristics through a novel plasma deposition method
Laurent-Brocq, Mathilde; Job, Nathalie ULg; Eskenazi, David ULg et al

in Applied Catalysis B : Environmental (2014), 147

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