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See detailFuture-oriented mental time travel in individuals with disordered gambling.
Noel, Xavier; Saeremans, Melanie; Kornreich, Charles et al

in Consciousness & Cognition (2017), 49

This study investigated the ability of individuals with disordered gambling to imagine future events. Problem gamblers (n=35) and control participants (n=35) were asked to imagine positive and negative ... [more ▼]

This study investigated the ability of individuals with disordered gambling to imagine future events. Problem gamblers (n=35) and control participants (n=35) were asked to imagine positive and negative future events for three temporal distances (one week, one year, 5-10years). Then, a variety of phenomenological aspects of their future thoughts (e.g., sensory and contextual details, autonoetic consciousness) were rated. Compared to control subjects, problem gamblers generated fewer positive and negative events across all temporal distances, an impairment that was correlated to verbal fluency scores. Furthermore, problem gamblers rated imagined events as containing fewer sensory and contextual details, and lacking autonoetic consciousness. These findings demonstrate that problem gambling is associated with a reduced future-oriented mental time travel ability and, in particular, with diminished autonoetic consciousness when imagining future events. [less ▲]

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See detailOn Sustainable Aquaculture
Tran Thi Nang, Thu; Lebailly, Philippe ULg

in Oceanography & Fisheries (2017), 1(3), 001-002

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See detailCooking Has Variable Effects on the Fermentability in the Large Intestine of the Fraction of Meats, Grain Legumes, and Insects That Is Resistant to Digestion in the Small Intestine in an in Vitro Model of the Pig’s Gastrointestinal Tract
POELAERT, Christine ULg; Despret, Xavier; Sindic, Marianne ULg et al

in Journal of Agricultural and Food Chemistry (2017), 65

This study aimed to evaluate the fermentation in the large intestine of indigestible dietary protein sources from animal, insect, and plant origin using an in vitro model of the pig’s gastrointestinal ... [more ▼]

This study aimed to evaluate the fermentation in the large intestine of indigestible dietary protein sources from animal, insect, and plant origin using an in vitro model of the pig’s gastrointestinal tract. Protein sources were used raw and after a cooking treatment. Results showed that the category of the ingredient (meats, insects, or grain legumes) exerts a stronger impact on enzymatic digestibility, fermentation patterns, and bacterial metabolites such as short-chain fatty acids (SCFA) and hydrogen sulfide (H2S) than the cooking treatment. The digestibility and the fermentation characteristics of insects were more affected by the cooking procedure than the other categories. Per gram of consumed food, ingredients from animal origin, namely, meats and insects, were associated with fewer fermentation end-products (gas, H2S, SCFA) than ingredients from plant origin, which is related to their higher small intestinal digestibility. [less ▲]

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See detailTemperature Preference and Sex Differentiation in African Catfish, Clarias gariepinus
Santi, Saïdou; Rougeot, Carole ULg; Toguyeni, Aboubacar et al

in Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology (2017)

The African catfish Clarias gariepinus has a genetic sex determination system in which high temperature induces masculinization. The thermosensitive period for sex differentiation is short and occurs very ... [more ▼]

The African catfish Clarias gariepinus has a genetic sex determination system in which high temperature induces masculinization. The thermosensitive period for sex differentiation is short and occurs very early (from 6 to 8 days posthatching [dph]). As young juveniles can encounter high masculinizing temperature (36.5°C) in African water points, we aimed to determine the thermal preference of sexually undifferentiated juveniles and investigate if they spontaneously move toward high masculinizing temperature. Experiments were carried out in an environmental continuum (28–28–28°C and 28–32–36.5°C) made up of three 50-L aquariums connected together. Four hundred larvae from 10 different full-sib progenies were reared successively from 2 to 14 dph in these facilities. Before and after thermal treatments, fish were reared at 28°C until sex ratio determination at 70 dph. In the control continuum, fish were nearly equally distributed in the three compartments. Conversely, in the thermal continuum, compartment occupation significantly differed with progeny and period. During the highly thermosensitive period, two of five progenies significantly preferred (54.7% and 39.8% occupation) the 36.5°C compartment. All tested progenies reared in thermal continuum and separated 36.5°C aquarium showed a skewed sex ratio toward the male phenotype (78–100%). Nevertheless, no correlation was found between 36.5°C compartment occupation and sex ratio in thermal continuum groups. As masculinization temperature could be encountered in African water points during the spawning season, we discussed the adaptive advantage for the African catfish to display a sex differentiation process controlled by a temperature effect. [less ▲]

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See detailTowards an Australian Philosophy. Constructive Appropriation of Enlightenment Thinking in Murray Bail's The Pages
Herbillon, Marie ULg

in Tunca, Daria; Wilson, Janet (Eds.) Postcolonial Gateways and Walls: Under Construction (2017)

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See detailMurray Bail's Eucalyptus: An Australian Fairy-Tale?
Herbillon, Marie ULg

in Collier, Gordon; Davis, Geoff; Delrez, Marc (Eds.) et al The Cross-Cultural Legacy: Critical and Creative Writings in Memory of Hena Maes-Jelinek (2017)

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See detailA tailored two-phase constructive heuristic for the three-dimensional Multiple Bin Size Bin Packing Problem with transportation constraints
Paquay, Célia ULg; Limbourg, Sabine ULg; Schyns, Michael ULg

E-print/Working paper (2017)

This paper considers the three-dimensional Multiple Bin Size Bin Packing Problem which consists in packing a set of cuboid boxes into containers of various shapes with minimising unused space. The problem ... [more ▼]

This paper considers the three-dimensional Multiple Bin Size Bin Packing Problem which consists in packing a set of cuboid boxes into containers of various shapes with minimising unused space. The problem is extended to air cargo where bins are Unit Load Devices, especially designed for fitting in aircraft. We developed a fast constructive heuristic able to manage the different constraints met in transportation. The heuristic is split into two distinct phases. The first phase deals with the packing of boxes into identical bins using an extension of the Extreme Points. During this phase, the fragility, stability and orientations of the boxes are taken into account as well as the special shape of the bins and their weight capacity. The second phase takes into account the multiple types of available bins. If necessary, the best found loading pattern is finally enhanced with respect to weight distribution in a post processing. After parametrisation, computational experiments have been performed on data sets especially designed for this application. The heuristic requires really short computational times to achieve promising results. [less ▲]

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See detailNumerical modelling of microscopic lubricant flow in sheet metal forming. Application to plane strip drawing
Carretta, Yves; Bech, Jacob; Legrand, Nicolas et al

in International Journal for Numerical Methods in Engineering (2017)

This paper presents a numerical investigation of microscopic lubricant flows from the cavities to the plateaus of the surface roughness of metal sheets during forming processes. This phenomenon, called ... [more ▼]

This paper presents a numerical investigation of microscopic lubricant flows from the cavities to the plateaus of the surface roughness of metal sheets during forming processes. This phenomenon, called micro-plastohydrodynamic lubrication, was observed experimentally in various situations such as compression sliding tests, strip drawing and cold rolling. It leads to local friction drop and wear reduction. It is therefore critical to achieve a good understanding of this phenomenon. As to move towards that goal, a multiscale fluid–structure interaction model is developed to model lubricant flows at the microscopic scale. These simulations are made possible through the use of the Arbitrary Lagrangian Eulerian (ALE) formalism. In this paper, this methodology is used to study plane strip drawing. The numerical model is able to predict the onset of lubricant escape and the amount of lubricant flowing on the plateaus. Numerical results exhibit good agreement with experimental measurements. [less ▲]

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See detailThe need for careful data collection for pattern recognition in digital pathology
Marée, Raphaël ULg

in Journal of Pathology Informatics (2017)

Effective pattern recognition requires carefully designed ground-truth datasets. In this technical note, we first summarize potential data collection issues in digital pathology and then propose ... [more ▼]

Effective pattern recognition requires carefully designed ground-truth datasets. In this technical note, we first summarize potential data collection issues in digital pathology and then propose guidelines to build more realistic ground-truth datasets and to control their quality. We hope our comments will foster the effective application of pattern recognition approaches in digital pathology. [less ▲]

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See detailA Stochastic Multi-scale Model For Predicting MEMS Stiction Failure
Hoang Truong, Vinh ULg; Wu, Ling ULg; Paquay, Stéphane et al

in Starman, La Vern; Hay, Jennifer; Karanjgaokar, Nikhil (Eds.) Micro and Nanomechanics, Volume 5: Proceedings of the 2016 Annual Conference on Experimental and Applied Mechanics (2017)

Adhesion is an important phenomenon in the context of MEMS for which the surface forces become dominant in comparison with the body forces. Because the magnitudes of the adhesive forces strongly depend on ... [more ▼]

Adhesion is an important phenomenon in the context of MEMS for which the surface forces become dominant in comparison with the body forces. Because the magnitudes of the adhesive forces strongly depend on the surface interaction distances, which in turn evolve with the roughness of the contacting surfaces, the adhesive forces cannot be determined in a deterministic way. To quantify the uncertainties on the structural stiction behavior of a MEMS, this work proposes a “stochastic multi-scale methodology”. The key ingredient of the method is the evaluation of the random meso-scale apparent contact forces, which homogenize the effect of the nano-scale roughness and are integrated into a numerical model of the studied structure as a random contact law. To obtain the probabilistic behavior at the structural MEMS scale, a direct method needs to evaluate explicitly the meso-scale apparent contact forces in a concurrent way with the stochastic multi-scale approach. To reduce the computational cost, a stochastic model is constructed to generate the random meso-scale apparent contact forces. To this end, the apparent contact forces are parameterized by a vector of parameters before applying a polynomial chaos expansion in order to construct a mathematical model representing the probability of the random parameters vector. The problem of micro-beam stiction is then studied in a probabilistic way. [less ▲]

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See detailFormaliser le trope : De la subjectivité linguistique à la subjectivité épilinguistique
Mathy, Adrien ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (2017)

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See detailLa mise en œuvre du droit de plainte en Belgique francophone. Observation des processus de médiation en soins de santé
Dubois, Christophe ULg; Vandeninden, Elise ULg

in Revue Française des Affaires Sociales (2017), 1(1), 79-96

This article concerns the treatment of patients’ rights cases in French‐speaking Belgian hospitals by the “mediator”, that is, the person who has the legal duty of dealing with grievances arising from the ... [more ▼]

This article concerns the treatment of patients’ rights cases in French‐speaking Belgian hospitals by the “mediator”, that is, the person who has the legal duty of dealing with grievances arising from the application of this right of complaint. What happens to a patient’s complaint? This is the question that this article attempts to answer through a report on the “local” organization of mediation ser‐ vices within the hospital. It thus clari es the links and divergences between the formal discourses accompanying the implementation of the mediation function in health care on the one hand, and, on the other hand, the actual practices of media‐ tion determined by the work of mediators in the hospital. [less ▲]

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See detailA generic wear prediction procedure based on the Discrete Element Method for ball mill liners in the cement industry
Boemer, Dominik ULg; Ponthot, Jean-Philippe ULg

in Minerals Engineering (2017)

generic procedure to predict the wear evolution of lining surfaces, namely the spatial distribution of wear and the progressive modification of the geometry due to wear, is introduced in the context of ... [more ▼]

generic procedure to predict the wear evolution of lining surfaces, namely the spatial distribution of wear and the progressive modification of the geometry due to wear, is introduced in the context of shell liners in ball mills. The wear data is accumulated on the surface of the liner by 3D discrete element method (DEM) simulations of the ball charge in an axial slice of the mill, which is either closed by a periodic boundary condition or by frictionless end walls. The calibration of this wear data with the measured wear profiles of the shell liner in a 5.8 m diameter industrial cement tube mill shows that the tangential damping energy defined by the linear spring-slider-damper DEM contact law is the best fitting wear model of 6 different models. The gradual update of the liner shape delivers adequate results for liners without an axial height variation, while the accuracy of fully variable geometrical modifications is limited by the computation time. Nevertheless, detailed phenomena, like the creation of grooves in the liner, were for the first time numerically modeled. [less ▲]

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See detailOptimization and validation of a fast Supercritical Fluid Chromatography method for the quantitative determination of vitamin D3 and its related impurities.
Andri, Bertyl ULg; Lebrun, Pierre ULg; Dispas, Amandine ULg et al

in Journal of Chromatography. A (2017)

In the uprising context of green analytical chemistry, Supercritical Fluid Chromatography (SFC) is often suggested as an alternative to Normal Phase Liquid Chromatography. Indeed, SFC provides fast ... [more ▼]

In the uprising context of green analytical chemistry, Supercritical Fluid Chromatography (SFC) is often suggested as an alternative to Normal Phase Liquid Chromatography. Indeed, SFC provides fast, efficient and green separations. In this report, the quantitative performances of SFC were challenged on a real-life case study: the Quality Control (QC) of vitamin D3. A rapid and green SFC method was optimized thanks to the Design of Experiments–Design Space (DoE–DS) methodology. It provided robust and high quality separation of the compounds within a 2 min timeframe, using a gradient of ethanol as co-solvent of the carbon dioxide. The analytical method was fully validated according to the total error approach, demon- strating the compliance of the method to the specifications of U.S. Pharmacopeia (USP: 97.0–103.0%) and European Pharmacopeia (EP: 97.0–102.0%) for an interval of [50–150%] of the target concentration. In order to allow quantification of impurities using vitamin D3 as an external standard in SFC-UV, correction factors were determined and verified during method validation. Thus, accurate quantification of impu- rities was demonstrated at the specified levels (0.1 and 1.0% of the main compound) for a 70.0–130.0% dosing range. This work demonstrates the validity of an SFC method for the QC of vitamin D3 raw material and its application to real samples. Therefore, it supports the switch to a greener and faster separative technique as an alternative to NPLC in the pharmaceutical industry. [less ▲]

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See detailMethylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer.
Chiavarina, Barbara ULg; Nokin, Marie-Julie ULg; Bellier, Justine ULg et al

in International Journal of Molecular Sciences (2017), 18(1),

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and ... [more ▼]

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies including cancer. All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality. In this study, we used immunohistochemistry to examine the level of MG protein adducts, in a series of 102 CRC human tumors divided into four clinical stages. We consistently detected a high level of MG adducts and low GLO1 activity in high stage tumors compared to low stage ones suggesting a pro-tumor role for dicarbonyl stress. Accordingly, GLO1 depletion in CRC cells promoted tumor growth in vivo that was efficiently reversed using carnosine, a potent MG scavenger. Our study represents the first demonstration that MG adducts accumulation is a consistent feature of high stage CRC tumors. Our data point to MG production and detoxification levels as an important molecular link between exacerbated glycolytic activity and CRC progression. [less ▲]

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See detailRoad and intermodal transport performance: the impact of operational costs and air pollution external costs
Mostert, Martine ULg; Caris, An; Limbourg, Sabine ULg

in Research in Transportation Business & Management (2017)

The transportation of goods is essential for the economy, but it also contributes to air pollution which, in turn, affects human health. These negative impacts generate additional costs for society that ... [more ▼]

The transportation of goods is essential for the economy, but it also contributes to air pollution which, in turn, affects human health. These negative impacts generate additional costs for society that are not necessarily taken into account in public transportation policies and in private transportation decisions of companies and individuals. This leads to inefficient transportation systems where the social equilibrium is not reached. Intermodal transport is promoted by the European Commission to reduce these negative externalities. The objective of this paper is to analyze at a strategic level the effect on modal split between road, intermodal rail and intermodal inland waterway transport of several economic or environmental policies. An intermodal allocation model is applied to the Belgian case in order to identify the modal split changes between the single minimization of costs (operational or health-related external) and the introduction of additional road taxes. [less ▲]

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See detailRectal cancer treatment in a teaching hospital
Verdin, Vanessa; Weerts, Joseph; Francart, David et al

in Acta Chirurgica Belgica (2017), 117

Background: Rectal adenocarcinomas surgery morbidity and mortality might be impaired by neoadjuvant therapy. We performed this retropsective study to be compared with the PROCARE study running afterwards ... [more ▼]

Background: Rectal adenocarcinomas surgery morbidity and mortality might be impaired by neoadjuvant therapy. We performed this retropsective study to be compared with the PROCARE study running afterwards. Methods: We performed a retrospective study of 95 patients operated on for rectal denocarcinoma in a single institution during the period 2007-2009. We used logistic regression to estimate the relationship between possible predictive parameters of AL. Results: The laparoscopic approach is favored in 63.1% of the cases with a conversion rate of 11.6%, mainly in man (6 out of 7). For low rectal cancer though, laparotomy was the first choice (92.3%). From a carcinological point of view, laparoscopy allowed a complete tumor resection according to the PME (n=27) and TME (n=26) standards. Multivariate analysis revealed that women, lower BMI, lower rectum tumor, laparoscopic surgery, neoadjuvant treatment and anal suture were associated with higher risk of AL. The mean hospital stay was 15.4 days (3 – 46 days). In-hospital mortality was 3.1%. Adjuvant chemotherapy was completed in 42.1% of the patients. Despite these treatments, we registered a recurrence rate of 26.6%. Of these, 72% were distally localized and 12% exclusively locally. Among the patients operated on by laparoscopy, there was one local recurrence and one local with distant metastases (3.7%). The one- and three-years survival rates were 91.5% and 80.4% respectively. Conclusions: Our study showed a higher rate of AL than expected (18%). In our series recorded in PROCARE-Home, our leak rate has dropped to 10%. It may be indicating a positive effect of PROCARE. [less ▲]

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See detailCombination of Partial Least Squares regression and Design of Experiments to model the retention of pharmaceuticals in Supercritical Fluid Chromatography
Andri, Bertyl ULg; Dispas, Amandine ULg; Marini Djang'Eing'A, Roland ULg et al

in Journal of Chromatography. A (2017)

This work presents a first attempt to establish a model of the retention behaviour for pharmaceutical compounds in gradient mode SFC. For this purpose, multivariate statistics were applied on the basis of ... [more ▼]

This work presents a first attempt to establish a model of the retention behaviour for pharmaceutical compounds in gradient mode SFC. For this purpose, multivariate statistics were applied on the basis of data gathered with the Design of Experiment (DoE) methodology. It permitted to build optimally the experiments needed, and served as a basis for providing relevant physicochemical interpretation of the effects observed. Data gathered over a broad experimental domain enabled the establishment of well-fit linear models of the retention of the individual compounds in presence of methanol as co-solvent. These models also allowed the appreciation of the impact of each experimental parameter and their factorial combinations. This approach was carried out with two organic modifiers (i.e. methanol and ethanol) and provided comparable results. Therefore, it demonstrates the feasibility to model retention in gradient mode SFC for individual compounds as a function of the experimental conditions. This approach also permitted to highlight the predominant effect of some parameters (e.g. gradient slope and pressure) on the retention of compounds. Because building of individual models of retention was possible, the next step considered the estab- lishment of a global model of the retention to predict the behaviour of given compounds on the basis of, on the one side, the physicochemical descriptors of the compounds (e.g. Linear Solvation Energy Relationship (LSER) descriptors) and, on the other side, of the experimental conditions. This global model was established by means of partial least squares regression for the selected compounds, in an experimental domain defined by the Design of Experiment (DoE) methodology. Assessment of the model’s predic- tive capabilities revealed satisfactory agreement between predicted and actual retention (i.e. R2 = 0.942, slope = 1.004) of the assessed compounds, which is unprecedented in the field. [less ▲]

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See detailANTICANCER, ANTIPLASMODIAL AND ANTITRYPANOSOMAL ACTIVITIES OF CRUDE EXTRACTS OF PLATANUS ORIENTALIS
Ebralidze, L.; Mskhiladze, Lasha; Ledoux, Allison ULg et al

in World Journal of Pharmaceutical Research (2017), 6(3), 170-175

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