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See detailOrigines développementales des anomalies de l'homéostasie glucidique, de la croissance osseuse et prédisposition à l'ostéochondrose chez le poulain
Peugnet, Pauline ULg

Doctoral thesis (2014)

Fetal adaptations to intra-uterine stimuli have immediate and long term effects on the offspring’s health after birth. In equids, this concept known as the DOHaD (Developmental Origins of Health and ... [more ▼]

Fetal adaptations to intra-uterine stimuli have immediate and long term effects on the offspring’s health after birth. In equids, this concept known as the DOHaD (Developmental Origins of Health and Disease) was validated using crossbreeding: the mare’s size which affects the fetal environment throughout gestation and then lactation, has a critical impact on the foal’s post-natal growth, as well as on the neonate’s sensitivity to insulin. Osteochondrosis, a pathology of the growing horse, induces heavy financial losses in the equine industry. It has been associated to abnormalities in glucose homeostasis and its antenatal origin is highly suspected. The present research aimed to evaluate the impact of experimental disturbances during fetal development on growth, glucose homeostasis and predisposition to osteochondrosis in the foal until age 1½ year. Increased versus restricted fetal growth was obtained using between-breed embryo transfers (“ponies in draft horses” versus “saddlebreds in ponies”, respectively). The lush environment of the draft mare versus the restricted environment of the pony mare turned out to be critical in the regulation of bone growth, thyroid hormones secretion, β-cells function, insulin sensitivity and the osteoarticular status of the foal from birth to 1½ year of age. This validates the concept of the DOHaD in equids and shows that recipient mares should be carefully selected in embryo transfer practice. By demonstrating the scope of post-natal effects which were programmed in utero and throughout the lactating period, it also alerts the breeder about the importance of broodmare management and its long term impacts. Thus, the second model was developed to address breeders' practices. A disturbance of the nutritional environment of the fetus was induced by supplementing mares in late pregnancy with concentrated feed (barley). So far, only the neonatal foal's glucose homeostasis was affected, whereas all other studied parameters, including growth, were not affected. The foal’s predisposition to osteochondrosis, however, was increased at 6 months of age, which does not preclude that it will affect the animals afterwards since the osteoarticular status of the 6-month-old foal will evolve beyond weaning time. This research could help adjust nutritional recommendations to broodmares. [less ▲]

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See detailLes conséquences traumatiques de la maltraitance infantile
Garcet, Serge ULg

Article for general public (2014)

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Peer Reviewed
See detailIdentifying the best technical trading rule: a .632 bootstrap approach.
Hambuckers, julien ULg; Heuchenne, Cédric ULg

Conference (2014, December 07)

In this paper, we estimate the out-of-sample predictive ability of a set of trading rules. Usually, this ability is estimated using a rolling-window sample-splitting scheme, true out-of-sample data being ... [more ▼]

In this paper, we estimate the out-of-sample predictive ability of a set of trading rules. Usually, this ability is estimated using a rolling-window sample-splitting scheme, true out-of-sample data being rarely available. We argue that this method makes a poor use of the available information and creates data mining possibilities. Instead, we introduce an alternative bootstrap approach, based on the .632 bootstrap principle. This method enables to build in-sample and out-of-sample bootstrap data sets that do not overlap and exhibit the same time dependencies. We illustrate our methodology on IBM and Microsoft daily stock prices, where we compare 11 trading rules specifications. For the data sets considered, two different filter rule specifications have the highest out-of-sample mean excess returns. However, all tested rules cannot beat a simple buy-and-hold strategy when trading at a daily frequency. [less ▲]

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See detailL'Aurignacien de la grotte Yafteh et son contexte
Otte, Marcel ULg; Flas, Damien ULg; Zwyns, Nicolas et al

Poster (2014, December 06)

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See detailEvidence based medicine - Tendon and platelet-rich plasma (PRP)
Kaux, Jean-François ULg

in Annual Congress RSBPRM (2014, December 06)

Platelets have known roles in coagulation, inflammatory processes, and immunity modulation; they also have ‘‘restorative’’ properties. Indeed, during degranulation, platelets release different cytokines ... [more ▼]

Platelets have known roles in coagulation, inflammatory processes, and immunity modulation; they also have ‘‘restorative’’ properties. Indeed, during degranulation, platelets release different cytokines and growth factors (VEGF, PDGF, TGF-B, IGF-I, and HGF) that promote angiogenesis, tissue remodeling (bone, skin, muscle, tendon, etc.), and wound healing. PRP is obtained by centrifuging autologous blood to obtain a concentration of platelets, usually between 3 and 10 times that of whole blood, depending on the isolation method. For this reason, different PRP preparation techniques cannot provide a consistently identical final product, but there is currently no international consensus on this issue. Overall, PRP could be an attractive therapeutic option for treating chronic musculoskeletal conditions, such as tendinopathy or plantar fasciitis. Tendons do not have a high metabolic index. Growth factors released by platelets promote tenocyte proliferation, stimulate angiogenesis and have analgesic properties. Thus it could stimulate and accelerate tissue regeneration in animal models. In addition to PRP, optimal tissue quality requires the application of mechanical loads. PRP should be considered for chronic tendinopathies. Indeed, the goal is to initiate an acute inflammatory reaction that quickly moves on to the proliferative phase that involves collagen synthesis. The latter is necessary for appropriate tendon healing. PRP should therefore not be used for acute tendinitis or tenosynovitis. Even if most of the preclinical studies showed that PRP stimulates the tendon healing process, clinical series remain more controversial. Based on literature and our clinical experience, we suggest some ideas for improving this treatment. Optimization of the technique for collecting the PRP is paramount. Different risk factors must be corrected before infiltration, and chronic tendinopathies must be carefully selected. Finally, post-infiltration rehabilitation remains absolutely necessary. Standardisation of the use of PRP remains necessary in order to optimise the results. [less ▲]

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See detailCopropriété, superficie et emphytéose
Lecocq, Pascale ULg

Scientific conference (2014, December 06)

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Peer Reviewed
See detailLes ressources génétiques caprines en Algérie
Moula, Nassim ULg; Philippe, François-Xavier ULg; Ait Kaki, Asma et al

Poster (2014, December 06)

Detailed reference viewed: 28 (6 ULg)
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See detailScience at the fringe of the French colonial world: the circulation of Jean-André Peyssonnel’s treatises on medicine and the natural history of Guadeloupe
Vandersmissen, Jan ULg

Conference (2014, December 05)

Jean-André Peyssonnel, born in Marseille in 1694, was a physician who in 1720-1721 earned his spurs in the fight against the plague that ravaged his hometown. Fascinated by the sea and the work of ... [more ▼]

Jean-André Peyssonnel, born in Marseille in 1694, was a physician who in 1720-1721 earned his spurs in the fight against the plague that ravaged his hometown. Fascinated by the sea and the work of fishermen, he turned in following years to the study of marine life. While conducting observational research along the coasts of the Provence and North Africa, he found evidence of the animal nature of coral. This controversial claim caused a heated debate with Réaumur, who blocked his career plans in France. Out of necessity Peyssonnel was forced to accept the post of “Médecin du Roi” in Guadeloupe. In this remote outpost of the French colonial empire, Peyssonnel continued his scientific activities. He received orders to fight a local outburst of leprosy, which resulted in a comprehensive study on the disease. In addition, he produced dozens of treatises on the natural history of the French Antilles, including volcanic, oceanographic, botanical and zoological studies. This contribution tells the story of these remarkable documents which, on their way to the learned world in Europe, passed through many hands. Spread over several intellectual centres – London, Paris, Marseille, Rouen, Bordeaux, Angers – these manuscripts shed a unique light on the circulation of knowledge in a Republic of Sciences turning global. [less ▲]

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See detailMujeres, circuitos y fronteras en el sur del Ecuador.
Ramos Ordonez, Maria ULg

Doctoral thesis (2014)

La recherche doctorale de Patricia Ramos porte sur la thématique des femmes et circuits migratoires dans le Sud de l’Equateur. Plus précisément, elle va s’intéresser à l’agence (agency) et aux dynamiques ... [more ▼]

La recherche doctorale de Patricia Ramos porte sur la thématique des femmes et circuits migratoires dans le Sud de l’Equateur. Plus précisément, elle va s’intéresser à l’agence (agency) et aux dynamiques de pouvoir auxquelles sont confrontées les femmes étrangères et équatoriennes au niveau local dans une partie de l’Equateur caractérisée par une très forte mobilité des populations. [less ▲]

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See detailVieillissement, facteurs de vie et cognition
Grotz, Catherine ULg

Speech/Talk (2014)

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See detailCan Electrical Resistivity Tomography offer us a dynamic view on what happens in the soil-plant continuum?
Garré, Sarah ULg

Conference (2014, December 05)

Root water and nutrient uptake and its relation to environmental factors is one of the least understood components in the terrestrial water balance and is of high importance for water resources management ... [more ▼]

Root water and nutrient uptake and its relation to environmental factors is one of the least understood components in the terrestrial water balance and is of high importance for water resources management, ecology and agriculture. As the processes in the soil-plant continuum are complex and inextricably intertwined, alternative, non-invasive measurement methods are necessary to unravel spatial and temporal dynamics of the system. Electrical resistivity tomography (ERT) has been proposed as a promising technique, since bulk resistivity maps and their temporal evolution may serve as a proxy for changes in soil moisture and pore water salinity, amongst others. However, the variables affecting the measured bulk electrical resistivity often change simultaneously in natural environments and not all influencing factors are yet well understood (e.g. influence of root biomass). Therefore, the method needs field-specific calibration. In addition to limitations due to signal-to-noise ratio and data inversion strategies, this implies that ERT still needs further development and research efforts for its use to characterize the soil-plant continuum. [less ▲]

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See detailLa théorie des humeurs à l’aube de l’Europe vernaculaire
Valenti, Gianluca ULg

Conference (2014, December 05)

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See detailHypogonadisme génétique masculin: diagnostic et prise en charge
VALDES SOCIN, Hernan Gonzalo ULg

Scientific conference (2014, December 05)

The neuroendocrine control of reproduction in mammals is governed by a hypothalamic neural network of nearly 1500 gonadotropin-releasing hormone (GnRH) secreting neurons that modulate the activity of the ... [more ▼]

The neuroendocrine control of reproduction in mammals is governed by a hypothalamic neural network of nearly 1500 gonadotropin-releasing hormone (GnRH) secreting neurons that modulate the activity of the reproductive axis across life. Congenital Hypogonadotropic hypogonadism (HH) is a clinical syndrome that is characterized by partial or complete pubertal failure. HH may result from inadequate hypothalamic GnRH axis activation, or a failure of pituitary gonadotropin secretion/effects. In man, several genes that participate in olfactory and GnRH neuronal migration are thought to interact during the embryonic life. A growing list of mutations of these genes is responsible for congenital HH. Based on the presence or the absence of olfaction dysfunction, HH is divided in two syndromes: HH with olfactory alterations (Kallmann syndrome) and Idiopathic hypogonadotropic hypogonadism (IHH) with normal smell (normosmic IHH). Kallmann syndrome (KS) is a heterogeneous disorder affecting 1 in 5000 to 8000 males, with a 3-5 fold male excess over female. KS is associated with mutations in KAL1, FGFR1/FGF8, FGF17, IL17RD, PROK2/PROKR2, NELF, CHD7, HS6ST1 and WDR11 genes that are related to defects in neuronal migration. These reproductive and olfactory deficits include a variable non reproductive phenotype, including sensorineural deafness, coloboma, bimanual synkinesis, craniofacial abnormalities and/or renal agenesis. Interestingly, defects in PROKR2, FGFR1, FGF8, CHD7 and WDR11 genes are also associated with normosmic IHH, whereas mutations in KISS1/KISSR, TAC3/TACR3, GNRH1/GNRHR, βFSH and βLH are only present in patients with normosmic IHH. βLH mutations are responsible for Pasqualini 's Syndrome (fertile eunuch) first described in 1950 in males with eunuchoidism, hypoandrogenism and spermatogenesis in testis biopsies. Congenital primary hypogonadism include several genetic syndromes such as Klinefelter syndrome (XXY), Del Castillo syndrome (only sertoli syndrome).In this lecture, we summarize the reproductive, neurodevelopmental and genetic aspects of IHH and primary hypogonadism in human pathology. [less ▲]

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See detailarchiDART: Plant Root System Architecture Analysis Using DART Output Files
Delory, Benjamin ULg; Baudson, Caroline ULg; Brostaux, Yves ULg et al

Computer development (2014)

archiDART is an R package allowing the analysis of complex plant root system architectures using the output files created by Data Analysis of Root Tracings (DART), an open-access software dedicated to the ... [more ▼]

archiDART is an R package allowing the analysis of complex plant root system architectures using the output files created by Data Analysis of Root Tracings (DART), an open-access software dedicated to the study of plant root architecture and development across time series (Le Bot et al (2010) DART: a software to analyse root system architecture and development from captured images, Plant and Soil, 326, 261--273). [less ▲]

Detailed reference viewed: 65 (9 ULg)
See detailRegistres de la langue en néo-égyptien: le cas des Tomb Robberies
Winand, Jean ULg

Conference (2014, December 05)

Detailed reference viewed: 15 (0 ULg)
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See detailAnd If It Was No ALS ?
WANG, François-Charles ULg

Scientific conference (2014, December 05)

Detailed reference viewed: 9 (1 ULg)