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See detailComparative Phytochemical Composition and Hypoglycemic Activity of Some Plants Used by Traditional Healers to Treat Diabetes in Kisangani
KATEMO MUHOYA, Frédéric; Kadima Ntokamunda, Justin-Léonard; Marini Djang'Eing'A, Roland ULiege

in International Journal of Pharmacy & Pharmaceutical REsearch (2017), Vol. 9(Issue 4), 312-321

Background: Phytochemical and Biological studies are always needed to define chemical composition, bioactivity and toxicity of plants from folk medicines before integrating them into conventional ... [more ▼]

Background: Phytochemical and Biological studies are always needed to define chemical composition, bioactivity and toxicity of plants from folk medicines before integrating them into conventional medicines. Here we compared phytochemical composition and antihyperglycemic activity of some plants used in Kisangani to treat diabetes. Methods: The plants tested are Aloe vera (AV), Bidens pilosa (BP), Cassia alata (CA), Cassia occidentalis (CO), Catharanthus roseus pink flower (CRp), Catharanthus roseus white flower or alba (CRw), Mangifera indica (MI), Morinda lucida (ML), Morinda morindoides (MM), Panda oleosa (PO), Terminalia catappa (TC), and Vernonia amygdalina (VA). Their content in polyphenols, saponins, alkaloids and mineral ash were compared. Hyperglycemia was induced in rabbits by oral glucose tolerance test with glibenclamide 0.2 mg/kg as reference. Blood glucose level was assayed by Folin-Wu photometric method. The mean percentage in glucose level reduction (MPR) was calculated from control untreated animals. The relative potency of each extract (RP) was calculated from glibenclamide MPR taken as 100%. Results: Flavonoids, tannins and saponins, were the main components; alkaloids were found only in CRp, CRw, ML and MM. The water content varied from 67% to 88%; Total ashes content was lower in roots (9%) than other parts (11-16%). Glibenclamide gave MPR=56.8% and RP=100%. MPR and RP for plant extracts were, ML(29.8%; 52.4%), CA(31.9%; 56.2%), MI(46.6%; 81.9%), MM(46.6%; 81.9%), TC(47.2%; 83.1%), VA(49.4%; 86.9%), CO(54.4%; 95.8%), CRw(57.4%; 101.0%), BP(60.8%; 107.0%), CRp(63.2%; 111.1%), AV(64.5%; 113.4%), PO(83.2%;146.3%). Conclusion: All plants but Panda oleosa have been studied by others; the main phytochemical groups reported have been confirmed in the local species. All plants exhibited some antihyperglycemic activity, differing however by their relative potency. [less ▲]

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See detailStable isotopes reveal effects of environmental changes on ecological niches of Iphimediidae amphipods
Michel, Loïc ULiege; d'Udekem d'Acoz, Cédric; Frederich, Bruno ULiege et al

Poster (2017, July)

When faced with environmental changes, organisms are expected to have some intrinsic ability to adapt through ecological plasticity. However, this process is still poorly understood in many Antarctic ... [more ▼]

When faced with environmental changes, organisms are expected to have some intrinsic ability to adapt through ecological plasticity. However, this process is still poorly understood in many Antarctic invertebrates. Here, we focused on Iphimediidae amphipods, as this widely distributed family shows important ecological diversity. In total, 248 amphipods (19 species) from two widely different zones (the West Antarctic Peninsula, or WAP, and Adélie Land, AL) were studied to elucidate how environment can influence ecological niche parameters. Ecological niches were explored using stable isotope ratios of carbon and nitrogen and the SIBER approach (Jackson et al., 2011). The isotopic niche of the whole amphipod assemblage was wider in WAP than in AL. This was true for both total (proxy of the whole range of resources exploited by animals) and the core (proxy of the most commonly used resources) isotopic niches. The ratio between total and core isotopic niches was smaller in WAP than in AL (4.13 vs. 5.74), suggesting that in WAP, animals commonly use a greater relative percentage of the resources to which they have access. Niche modelling at the specific level revealed that this trend was not found in all taxa. For example, niches of Gnathiphimedia sexdentata and Iphimediella microdentata were bigger in WAP than in AL, following the general pattern. On the other hand, niches of Echiniphimedia echinata and E. hodgsoni had the same width in both areas. Moreover, relative niche overlap between these two species was much higher in WAP (42%) than in AL (20%). Our results indicate that the widely different environmental conditions encountered by the animals in these two zones clearly influence their ecology. Overall, Iphimediidae amphipods tend to exploit more resources in WAP, i.e. in the zone where impacts of global change (temperature increase, sea ice cover decrease) are the strongest. Niche overlap between some closely related (i.e. congeneric) species was also more important in WAP. Ultimately, environmental changes in this region might reinforce these trends, which might lead to competition and perturb amphipod community structure. This research was funded by the Belgian Federal Science Policy Office (BELSPO) in the framework of the vERSO and RECTO projects. [less ▲]

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See detailPatrimoine culturel immatériel et musée : Acquérir, conserver, étudier, exposer et transmettre
Postula, Jean-Louis ULiege; Gob, André ULiege

in Lempereur, Françoise (Ed.) Patrimoine culturel immatériel - Manuel (2017)

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See detailÉtude de cas : Une longue tradition d'enquêtes au Musée de la Vie wallonne
Postula, Jean-Louis ULiege

in Lempereur, Françoise (Ed.) Patrimoine culturel immatériel - Manuel (2017)

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See detailThe thermal structure of the Venus atmosphere: Intercomparison of Venus Express and ground based observations of vertical temperature and density profiles✰
Limaye, Sanjay S.; Lebonnois, Sebastien; Mahieux, Arnaud et al

in Icarus (2017), 294

The Venus International Reference Atmosphere (VIRA) model contains tabulated values of temperature and number densities obtained by the experiments on the Venera entry probes, Pioneer Venus Orbiter and ... [more ▼]

The Venus International Reference Atmosphere (VIRA) model contains tabulated values of temperature and number densities obtained by the experiments on the Venera entry probes, Pioneer Venus Orbiter and multi-probe missions in the 1980s. The instruments on the recent Venus Express orbiter mission generated a significant amount of new observational data on the vertical and horizontal structure of the Venus atmosphere from 40 km to about 180 km altitude from April 2006 to November 2014. Many ground based experiments have provided data on the upper atmosphere (90-130 km) temperature structure since the publication of VIRA in 1985. The "Thermal Structure of the Venus Atmosphere" Team was supported by the International Space Studies Institute (ISSI), Bern, Switzerland, from 2013 to 2015 in order to combine and compare the ground-based observations and the VEx observations of the thermal structure as a first step towards generating an updated VIRA model. Results of this comparison are presented in five latitude bins and three local time bins by assuming hemispheric symmetry. The intercomparison of the ground-based and VEx results provides for the first time a consistent picture of the temperature and density structure in the 40 km-180 km altitude range. The Venus Express observations have considerably increased our knowledge of the Venus atmospheric thermal structure above ∼40 km and provided new information above 100 km. There are, however, still observational gaps in latitude and local time above certain regions. Considerable variability in the temperatures and densities is seen above 100 km but certain features appear to be systematically present, such as a succession of warm and cool layers. Preliminary modeling studies support the existence of such layers in agreement with a global scale circulation. The intercomparison focuses on average profiles but some VEx experiments provide sufficient global coverage to identify solar thermal tidal components. The differences between the VEx temperature profiles and the VIRA below 0.1 mbar/95 km are small. There is, however, a clear discrepancy at high latitudes in the 10-30 mbar (70-80 km) range. The VEx observations will also allow the improvement of the empirical models (VTS3 by Hedin et al., 1983 and VIRA by Keating et al., 1985) above 0.03 mbar/100 km, in particular the 100-150 km region where a sufficient observational coverage was previously missing. The next steps in order to define the updated VIRA temperature structure up to 150 km altitude are (1) define the grid on which this database may be provided, (2) fill what is possible with the results of the data intercomparison, and (3) fill the observational gaps. An interpolation between the datasets may be performed by using available General Circulation Models as guidelines. An improved spatial coverage of observations is still necessary at all altitudes, in latitude-longitude and at all local solar times for a complete description of the atmospheric thermal structure, in particular on the dayside above 100 km. New in-situ observations in the atmosphere below 40 km are missing, an altitude region that cannot be accessed by occultation experiments. All these questions need to be addressed by future missions. [less ▲]

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See detailCyanobacterial Contribution to Travertine Deposition in the Hoyoux River System, Belgium
Kleinteich, Julia; Golubic, Stjepko; Pessi, Igor S. et al

in Microbial Ecology (2017), 74

Travertine deposition is a landscape-forming process, usually building a series of calcareous barriers differentiating the river flow into a series of cascades and ponds. The process of carbonate ... [more ▼]

Travertine deposition is a landscape-forming process, usually building a series of calcareous barriers differentiating the river flow into a series of cascades and ponds. The process of carbonate precipitation is a complex relationship between biogenic and abiotic causative agents, involving adapted microbial assemblages but also requiring high levels of carbonate saturation, spontaneous degassing of carbon dioxide and slightly alkaline pH. We have analysed calcareous crusts and water chemistry from four sampling sites along the Hoyoux River and its Triffoy tributary (Belgium) in winter, spring, summer and autumn 2014. Different surface textures of travertine deposits correlated with particular microenvironments and were influenced by the local water flow. In all microenvironments, we have identified the cyanobacterium Phormidium incrustatum (Nägeli) Gomont as the organism primarily responsible for carbonate precipitation and travertine fabric by combining morphological analysis with molecular sequencing (16S rRNA gene and ITS, the Internal Transcribed Spacer fragments), targeting both field populations and cultures to exclude opportunistic microorganisms responding favourably to culture conditions. Several closely related cyanobacterial strains were cultured; however, only one proved identical with the sequences obtained from the field population by direct PCR. This strain was the dominant primary producer in the calcareous deposits under study and in similar streams in Europe. The dominance of one organism that had a demonstrated association with carbonate precipitation presented a valuable opportunity to study its function in construction, preservation and fossilisation potential of ambient temperature travertine deposits. These relationships were examined using scanning electron microscopy and Raman microspectroscopy. [less ▲]

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See detailRECONSTRUCTION DE L'ÉVOLUTION DU RAYONNEMENT SOLAIRE REÇU EN SURFACE EN EUROPE OCCIDENTALE SUR LA PÉRIODE 1900-2014 À L'AIDE DU MODÈLE ATMOSPHÉRIQUE RÉGIONAL MAR
Wyard, Coraline ULiege; Fettweis, Xavier ULiege; Belleflamme, Alexandre ULiege et al

in Dahech, Salem; Charfi, Sami (Eds.) Actes du XXXe colloque de l'Association Internationale de Climatologie : Climat, ville et environnement (2017, July)

Many studies show that the surface solar radiation has underwent large variations over the second half of the 20th century as a result of variations in cloud cover and aerosol loading in the atmosphere ... [more ▼]

Many studies show that the surface solar radiation has underwent large variations over the second half of the 20th century as a result of variations in cloud cover and aerosol loading in the atmosphere. However, it is difficult to build strong conclusions before the 1950' because of the observations scarcity. The evolution of the surface solar radiation has been reconstructed over 1900-2014 using the regional model MAR (« Modèle Atmosphérique Régional ») in Belgium. Boundary conditions were provided by four reanalysis products : the ERA-interim (1979-2014) completed by the ERA40 (1958-1978), the NCEP/NCAR-v1 (1948-2014), the ERA-20C (1900-2010) and the 20CRV2C (1900-2010). Results show that the reanalyses can generate divergent trends while they assimilate observations and are supposed to represent the same climate. [less ▲]

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See detailSpecular sets
Berthé, Valérie; De Felice, Clelia; Delecroix, Vincent et al

in Theoretical Computer Science (2017), 684

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See detailMacroevolutionary analysis of the tempo of diversification in snappers and fusiliers (Percomorpha: Lutjanidae)
Frederich, Bruno ULiege; Santini, Francesco

in Belgian Journal of Zoology (2017), 147(1), 17-35

The percomorph fish family Lutjanidae (snappers and fusiliers) includes about 135 reef-dwelling species, mainly confined to tropical and subtropical marine waters. The great majority of snappers are ... [more ▼]

The percomorph fish family Lutjanidae (snappers and fusiliers) includes about 135 reef-dwelling species, mainly confined to tropical and subtropical marine waters. The great majority of snappers are active predators feeding on fishes or crustaceans, even though some species, including the fusiliers (Caesioninae), have evolved zooplanktivory. Lutjanids show a great diversity of habitat preferences, based on depth segregation and distribution across reef and associated habitats (e.g. mangroves, seagrass beds, estuaries). In spite of their great ecological and economic importance little is known about the tempo of evolution in this group. The present study provides the most comprehensive molecular phylogeny to date for lutjanids, including 70% of extant species and 19 of the 21 currently described genera. We time-calibrated our molecular tree using the oldest described lutjanid fossils, and show how this group likely originated during the Late Cretaceous to Early Paleocene. Lutjanids experienced significant radiation during the Late Eocene and Early Oligocene, in contrast to a pattern of Late Oligocene/Miocene radiation observed in many other reef-associated groups. The time-tree allows us to investigate the tempo of diversification, and our results suggest a variation in the rate of speciation during the evolution of the major clade formed by “lutjanins and caesionins”. Variation in diet and life history strategies could explain this clade-specific dynamic, even though future phylogenetic comparative studies combining additional ecological and morphological data are needed to test this hypothesis. [less ▲]

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See detailDevelopment of an Ericsson Heat Engine for biomass Combined Heat and Power
Oudkerk, Jean-François ULiege; Lemort, Vincent ULiege

in Proceedings of the 30th International conference on Efficiency, Cost, Optimization, Simulation and Environmental Impact of Energy Systems (ECOS) (2017, July)

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See detailInfusion of mesenchymal stromal cells after deceased liver transplantation: A phase I-II, open-label, clinical study.
DETRY, Olivier ULiege; VANDERMEULEN, Morgan ULiege; DELBOUILLE, Marie-Hélène ULiege et al

in Journal of Hepatology (2017), 67(1), 47-55

BACKGROUND & AIM: Mesenchymal stromal cell (MSC) infusion could be a mean to establish tolerance in solid organ recipients. The aim of this prospective, controlled, phase-1 study was to evaluate the ... [more ▼]

BACKGROUND & AIM: Mesenchymal stromal cell (MSC) infusion could be a mean to establish tolerance in solid organ recipients. The aim of this prospective, controlled, phase-1 study was to evaluate the feasibility, safety and tolerability of a single infusion of MSCs in liver transplant recipients. METHODS: Ten liver transplant recipients under standard immunosuppression received 1.5-3x106/kg third-party unrelated MSCs on post-operative day 3+/-2, and were prospectively compared to a control group of 10 liver transplant recipients. As primary end-points, MSC infusional toxicity was evaluated, and infectious and cancerous complications were prospectively recorded until month 12 in both groups. As secondary end-points, rejection rate, month-6 graft biopsies, and peripheral blood lymphocyte phenotyping were compared. Progressive immunosuppression weaning was attempted from month 6 to 12 in MSC recipients. RESULTS: No variation in vital parameters or cytokine release syndrome could be detected during and after MSC infusion. No patient developed impairment of organ functions (including liver graft function) following MSC infusion. No increased rate of opportunistic infection or de novo cancer was detected. As secondary end-points, there was no difference in overall rates of rejection or graft survival. Month-6 biopsies did not demonstrate a difference between groups in the evaluation of rejection according to the Banff criteria, in the fibrosis score or in immunohistochemistry (including Tregs). No difference in peripheral blood lymphocyte typing could be detected. The immunosuppression weaning in MSC recipients was not successful. CONCLUSIONS: No side effect of MSC infusion at day 3 after liver transplant could be detected, but this infusion did not promote tolerance. This study opens the way for further MSC or Treg-based trials in liver transplant recipients. LAY SUMMARY: Therapy with mesenchymal stromal cells (MSCs) has been proposed as a mean to improve results of solid organ transplantation. One of the potential MSC role could be to induce tolerance after liver transplantation, i.e. allowing the cessation of several medications with severe side effects. This study is the first-in-man use of MSC therapy in 10 liver transplant recipients. This study did not show toxicity after a single MSC infusion but it was not sufficient to allow withdrawal of immunosuppression. [less ▲]

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See detailMultiple uprising invasions of Pelophylax water frogs, potentially inducing a new hybridogenetic complex
Dufresne, Christophe; Denoël, Mathieu ULiege; Di Santo, Lionel et al

in Scientific Reports (2017), 7

The genetic era has revolutionized our perception of biological invasions. Yet, it is usually too late to understand their genesis for efficient management. Here, we take the rare opportunity to ... [more ▼]

The genetic era has revolutionized our perception of biological invasions. Yet, it is usually too late to understand their genesis for efficient management. Here, we take the rare opportunity to reconstruct the scenario of an uprising invasion of the famous water frogs (Pelophylax) in southern France, through a fine-scale genetic survey. We identified three different taxa over less than 200 km2: the autochthonous P. perezi, along with the alien P. ridibundus and P. kurtmuelleri, which have suddenly become invasive. As a consequence, the latter hybridizes and may now form a novel hybridogenetic complex with P. perezi, which could actively promote its replacement. This exceptional situation makes a textbook application of genetics to early-detect, monitor and understand the onset of biological invasions before they pose a continental-wide threat. It further emphasizes the alarming rate of amphibian translocations, both at global and local scales, as well as the outstanding invasive potential of Pelophylax aliens. [less ▲]

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See detailBuilding a digital agenda for cultural diversity: UNESCO, new governance norms for culture and power dynamics
Vlassis, Antonios ULiege

in Quaderns del CAC (2017), XX(43), 47-54

The Convention on the Protection and Promotion of the Diversity of Cultural Expressions (CDCE) adopted by UNESCO in 2005 is now a key international instrument in the global governance of culture. In ... [more ▼]

The Convention on the Protection and Promotion of the Diversity of Cultural Expressions (CDCE) adopted by UNESCO in 2005 is now a key international instrument in the global governance of culture. In December 2016, the CDCE’s Committee adopted Operational Guidelines in order to align the CDCE with the development of digital technologies. In this respect, this article deals with the struggles between actors in the process for adopting new governance norms for the diversity of cultural expressions in the digital context and it seeks to understand how the interests and influence of the actors involved intersect in consensual and conflicting ways. [less ▲]

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See detailEver invested. Ever failed. No matter. Invest again. Invest better.
Choffray, Jean-Marie ULiege; Pahud de Mortanges, Charles ULiege

Book published by Amazon, Kindle Edition (2017)

Welcome to the “desert of the markets”, where businesses are playthings for bigger forces! The goal of this book is to share with you what we observed on the markets over the last twenty years, and what ... [more ▼]

Welcome to the “desert of the markets”, where businesses are playthings for bigger forces! The goal of this book is to share with you what we observed on the markets over the last twenty years, and what we believe to have learned as to their behavior. The end-product is a set of several hundred “experience-filtered” thoughts, facts and rules whose any subset could provide a reasonable basis on which to build your own theory of investing. Painful and solitary work. But, your survival on the markets is at that price. In its current 2017 edition, “Ever invested. Ever Failed. No matter. Invest again. Invest better.” is organized into seven chapters: The Great Recession of 2008; Businesses, assets and liabilities; Assessing market response; Financial engineering tricks and traps; Investors, swindlers and thieves; Rules for asset protection; Investing under non-parametric uncertainty. It concludes with a discussion of A few common myths and some Final thoughts on the art and science of investing. Each chapter comprises a short introduction, followed by an extensive, and unordered, list of thoughts, facts and rules that should help you articulate your information, decision and reward systems. [less ▲]

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See detailStandardized Settling Cell Design
Leleu, David ULiege; Pfennig, Andreas ULiege

Scientific conference (2017, July)

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See detailcopycat: Testing Differential Treatment of New Transport Protocols in the Wild
Edeline, Korian ULiege; Kühlewind, Mirja; Trammell, Brian et al

in Applied Networking Research Workshop (2017, July)

Recent years have seen the development of multiple transport solutions to address the ossification of TCP in the Internet, and to ease transport-layer extensibility and deployability. Recent approaches ... [more ▼]

Recent years have seen the development of multiple transport solutions to address the ossification of TCP in the Internet, and to ease transport-layer extensibility and deployability. Recent approaches, such as PLUS and Google's QUIC, introduce an upper transport layer atop UDP; their deployment therefore relies on UDP not being disadvantaged with respect to TCP by the Internet. This paper introduces copycat, a generic transport protocol testing tool that highlights differential treatment by the path in terms of connectivity and QoS between TCP and a non-TCP transport protocol. copycat generates TCP-shaped traffic with custom headers, and compares its performance in terms of loss and delay with TCP. We present a proof-of-concept case study (UDP vs. TCP) in order to answer questions about the deployability of current transport evolution approaches, and demonstrate the extent of copycat's capabilities and possible applications. While the vast majority of UDP impairments are found to be access-network linked, and subtle impairment is rare, middleboxes might adapt to new protocols that would then perform differently in the wild compared to early deployments or controlled environment testing. [less ▲]

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See detailTrajectory planning of soft link robots with improved intrinsic safety
Lismonde, Arthur ULiege; Sonneville, Valentin; Bruls, Olivier ULiege

in Proceedings of the 20th World Congress of the International Federation of Automatic Control (2017, July)

For human-robot cooperation, intrinsic safety approaches aim at reducing the energy involved in the motion of the robotic system and at increasing the system compliance in order to reduce the risk of ... [more ▼]

For human-robot cooperation, intrinsic safety approaches aim at reducing the energy involved in the motion of the robotic system and at increasing the system compliance in order to reduce the risk of injury in case of an unexpected collision. Robots based on lightweight and inherently exible links exhibit attractive features in this context but the control of their motion then leads to a tremendous challenge. This paper presents a novel trajectory planning method for 3D robots which aims at improving the tracking accuracy despite the link exibility. [less ▲]

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See detailÉvolution de l'enneigement moyen dans les Alpes au cours du 20e siècle à l'aide du modèle atmosphérique régional MAR
Belleflamme, Alexandre ULiege; Wyard, Coraline ULiege; Doutreloup, Sébastien ULiege et al

in Dahech, Salem; Charfi, Sami (Eds.) Actes du XXXème colloque de l'Association Internationale de Climatologie - Climat, ville et environnement (2017, July)

The evolution of the snow height over the Alps can strongly impact tourism, but also the water availability of the region. In this study, we have reproduced the evolution of the climate in the Alps over ... [more ▼]

The evolution of the snow height over the Alps can strongly impact tourism, but also the water availability of the region. In this study, we have reproduced the evolution of the climate in the Alps over the 20th century with the help of the regional atmospheric model MAR forced by three reanalyses (ERA-20C, NCEP/NCAR, and ERA-Interim). MAR shows that the snow height has increased since the beginning of the 20th century, first only at higher altitudes, then also at lower levels, before knowing a strong and abrupt decrease between 1985 and 1990. This evolution, which is consistent with observations given in the literature, is directly linked with the trends of NAO and AO. In fact, the atmospheric circulation changes highlighted by NAO and AO induce temperature and precipitation changes that directly determine the snow height in the Alps. [less ▲]

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See detailNew Alternatives to Chemical Pesticides: Deciphering the Action Mechanisms of Lipid based Plant Elicitors via Complementary Biophysical and Biological Approaches
Fauconnier, Marie-Laure ULiege

Scientific conference (2017, July)

An elicitor may be defined as any molecule produced by pathogenic or non-pathogenic microorganisms or by host plants (synthesizing or accumulating the molecule) capable of inducing or promoting the ... [more ▼]

An elicitor may be defined as any molecule produced by pathogenic or non-pathogenic microorganisms or by host plants (synthesizing or accumulating the molecule) capable of inducing or promoting the natural resistance of plants to one or more pathogens, which resistance may be local or systemic. [less ▲]

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