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See detailL’effet d’un dispositif public belge d’accompagnement sur les parcours professionnels des demandeurs d’emploi
Gérard, Julie ULg

in Meilland, Christèle; Sarfati François, François (Eds.) Accompagner vers l'emploi : quand les dispositifs se mettent en action (2015)

Suite aux récents bouleversements économiques et sociaux touchant les pays de l’Union Européenne, de nombreuses collaborations entre services publics et agences d’emploi privées se sont développées et ... [more ▼]

Suite aux récents bouleversements économiques et sociaux touchant les pays de l’Union Européenne, de nombreuses collaborations entre services publics et agences d’emploi privées se sont développées et complexifiées, suivant une logique de gestion mixte du marché du travail. Cette recherche porte sur l’étude d’un partenariat public-privé entre un service public régional de l’emploi belge et une entreprise marchande. À partir des apports conceptuels et théoriques de la sociologie de l’action publique, nous analyserons la capacité d’un dispositif public à assurer la remise à l’emploi de son public-cible. Pour ce faire, nous étudierons son rôle et ses effets sur les trajectoires professionnelles des demandeurs d’emploi y recourant. [less ▲]

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See detailComplex dynamics of a nonlinear aerospace structure: numerical continuation and normal modes
Renson, Ludovic ULg; Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg

in Nonlinear Dynamics (2015), 79(2), 1293-1309

This paper investigates the dynamics of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. A full-scale finite element model is built for gaining ... [more ▼]

This paper investigates the dynamics of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. A full-scale finite element model is built for gaining additional insight into the nonlinear dynamics that was observed experimentally, but also for uncovering additional nonlinear phenomena, such as quasiperiodic regimes of motion. Forced/unforced, damped/undamped numerical simulations are carried out using advanced techniques and theoretical concepts such as numerical continuation and nonlinear normal modes. [less ▲]

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See detailRethinking Vulnerability Analysis and Governance with Emphasis on a Participatory Approach
Rossignol, Nicolas ULg; Delvenne, Pierre ULg; Turcanu, Catrinel

in Risk Analysis : An Official Publication of the Society for Risk Analysis (2015), 35(1), 129-141

This paper draws on vulnerability analysis as it emerged as a complement to classical risk analysis, and it aims at exploring its ability of nurturing risk and vulnerability governance actions. An ... [more ▼]

This paper draws on vulnerability analysis as it emerged as a complement to classical risk analysis, and it aims at exploring its ability of nurturing risk and vulnerability governance actions. An analysis of the literature on vulnerability analysis allows us to formulate a threefold critique: first, vulnerability analysis has been treated separately in the natural and the technological hazards fields. This separation prevents vulnerability to unleash the full range of its potential, as it constraints appraisals into artificial categories and thus already closes down the outcomes of the analysis. Second, vulnerability analysis focused on assessment tools that are mainly quantitative, whereas qualitative appraisal is a key to assessing vulnerability in a comprehensive way and to informing policy-making. Third, a systematic literature review of case studies reporting on participatory approaches to vulnerability analysis allows us to argue that participation has been important to address the above, but it remains too closed down in its approach and would benefit from embracing a more open, encompassing perspective. Therefore, we suggest rethinking vulnerability analysis as one part of a dynamic process between opening-up and closing-down strategies, in order to support a vulnerability governance framework. [less ▲]

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See detailAllogeneic hematopoietic stem cell transplantation for T-prolymphocytic leukemia: a report from the French society for stem cell transplantation (SFGM-TC)
Guillaume, Thierry; Beguin, Yves ULg; Tabrizi, Reza et al

in European Journal of Haematology (2015), 94

T-prolymphocytic leukemia (T-PLL), a rare aggressive mature T-cell disorder, remains frequently resistant to conventional chemotherapy. Studies have suggested that allogeneic hematopoietic stem cell ... [more ▼]

T-prolymphocytic leukemia (T-PLL), a rare aggressive mature T-cell disorder, remains frequently resistant to conventional chemotherapy. Studies have suggested that allogeneic hematopoietic stem cell transplantation (HSCT) might possibly serve to consolidate the response to initial chemotherapy. The current report summarizes the outcome of 27 T-PLL cases identified in the registry in French Society for stem cell transplantation (SFGM-TC). Prior to HSCT, 14 patients were in complete remission (CR), 10 in partial response, three refractory, or in progression. Following HSCT, 21 patients achieved CR as best response. With a median follow-up for surviving patients of 33 (range, 6–103) months, 10 patients are still alive in continuous CR. Overall survival and progression-free survival estimates at 3 yr were 36% (95% CI: 17–54%) and 26% (95% CI: 14–45%), respectively. The relapse incidence after HSCT was 47% occurring at a median of 11.7 (range, 2–24) months. Overall cumulative incidence of transplant-related mortality was 31% at 3 yr. These results suggest that HSCT may allow long-term survival in patients with T-PLL following induction treatment; however, it is associated with a significant rate of toxicity. [less ▲]

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See detailBilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway
Alhosin, Mahmoud; León-González1, Antonio J.; Dandache et al

in Scientific Reports (2015), 5

Defect in apoptosis has been implicated as a major cause of resistance to chemotherapy observed in B cell chronic lymphocytic leukaemia (B CLL). This study evaluated the pro-apoptotic effect of an ... [more ▼]

Defect in apoptosis has been implicated as a major cause of resistance to chemotherapy observed in B cell chronic lymphocytic leukaemia (B CLL). This study evaluated the pro-apoptotic effect of an anthocyanin-rich dietary bilberry extract (Antho 50) on B CLL cells from 30 patients and on peripheral blood mononuclear cells (PBMCs) from healthy subjects, and determined the underlying mechanism. Antho 50 induced concentration- and time-dependent pro-apoptotic effects in B CLL cells isolated from patients but little or no effect in PBMCs. Among the main phenolic compounds present in this bilberry extract, delphinidin-3-O-glucoside and delphinidin-3-O-rutinoside showed the highest apoptotic effect on B CLL cells, suggesting that anthocyanins play a main role in the cytotoxic activity. Antho 50-induced apoptosis is associated with activation of caspase 3 and down-regulation of the anti-apoptotic protein UHRF1. Antho 50 induced also rapid dephosphorylation of Akt and Bad, and down-regulation of Bcl-2 resulting in reduced cell viability. Antho 50 significantly induced PEG-catalase-sensitive formation of reactive oxygen species in B CLL cells. PEG-catalase prevented the Antho 50-induced reduced cell viability, induction of apoptosis, up-regulation of caspase 3, down-regulation of UHRF1 and Bcl-2, and dephosphorylation of Bad. The present findings indicate that Antho 50 exhibits strong pro-apoptotic activity through redox-sensitive caspase 3 activation-related mechanism in B CLL cells involving dysregulation of Bad/Bcl-2 pathway. This activity is due, at least in part, to a composition rich on glucoside and rutinoside derivatives of delphinidin. They further suggest that Antho 50 has chemotherapeutic potential by targeting selectively B CLL cells. [less ▲]

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See detailLa saveur des échanges culturels
Mescoli, Elsa ULg

in Medhoune, Ahmed; Lausberg, Sylvie; Martiniello, Marco (Eds.) et al L’immigration marocaine en Belgique. Mémoires et destinées (2015)

Elaborer une réflexion à propos des passages d’éléments et caractères d’une culture à l’autre implique une préoccupation académique qui oblige à donner une définition au concept de culture. La culture de ... [more ▼]

Elaborer une réflexion à propos des passages d’éléments et caractères d’une culture à l’autre implique une préoccupation académique qui oblige à donner une définition au concept de culture. La culture de n’importe quel groupe de personnes ne peut pas être réduite à une liste d’éléments, bien que souvent cela soit fait pour permettre le développement de certains discours et politiques. Les frontières entre une culture et l’autre semblent se briser, non seulement à cause de la rencontre constante des différents gens grâce à la mobilité concrète et à l’imagination dans le monde globalisé, mais aussi de ce qu’une « logique métisse » met en évidence : les cultures ne seraient que le résultat d’une invention arbitraire et fonctionnelle de spécificités à partir d’un syncrétisme originaire. L’analyse des échanges culturels se situe alors entre la fluidité d’un concept (culture lue, interprétée, écrite ou inventée) et la concrétude de faits complexes. Les habitudes alimentaires dans la diaspora marocaine que je traite dans cet article constituent un de ces faits, terrain où s’entrelacent éléments biologiques, questions économiques, goûts, fois, normes, traditions, changements et où la rencontre avec l’altérité culturelle déclenche des dynamiques dignes de grandes attentions. [less ▲]

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See detailDesign of Pt/carbon xerogel catalysts for PEM fuel cells
Job, Nathalie ULg; Lambert, Stéphanie ULg; Zubiaur, Anthony ULg et al

in Catalysts (2015), 5

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See detailDevelopment of the Lémann Index to assess digestive tract damage in patients with Crohn's disease
Pariente, B; Mary, JY; Danese, S et al

in Gastroenterology (2015), 148

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See detailRituximab therapy for hairy cell leukemia : a retrospective study of 41 cases
Leclerc, Mathieu; Suarez, Felipe; Noël, Marie-Pierre et al

in Annals of Hematology (2015), 94

The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and ... [more ▼]

The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and new agents are needed to further improve treatment outcome. We retrospectively studied 41 HCL patients from 10 centers in France and Belgium, who received 49 treatment courses with the anti-CD20 monoclonal antibody rituximab. Most of the patients were treated at relapse (84 % of cases) and rituximab was combined to a PA in 41 % of cases. Overall, response rate is 90 % including 71 % complete hematologic responses (CHRs). Frontline treatment, combination therapy, and absolute neutrophil count were associated with response in multivariate analysis. Three-year relapse-free and overall survivals are 68 and 90 %, respectively. When combined to a PA, rituximab yields a 100 % response rate, even beyond frontline therapy. In contrast, response rate is only 82 % (59 % CHR) when rituximab is used alone. In this latter setting, relapse rate is 56 % and median time to relapse is 17.5 months. All eight patients who were treated two times with the antibody responded again to retreatment. We confirm the high efficacy of the combination rituximab + PA. However, when rituximab is used as monotherapy, response rate is lower and the high relapse rate is a concern. Prospective clinical trials are needed to confirm the superiority of the combination rituximab + PA over PA alone, both as frontline therapy and at relapse. [less ▲]

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See detailDevelopment of novel SOlid Materials for high power Li polymer BATteries (SOMABAT). Recyclability of components.
Zubizarreta, Leire; Gil-Agusti, Mayte; Garcia. et al

in Lecture notes on Mobility (2015)

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See detailAllogeneic hematopoietic stem cell transplantation in solid organ transplant recipients: a retrospective, multicenter study of the EBMT
Basak, GW.; Wiktor-Jedrzejczak, W.; Labopin, M. et al

in American Journal of Transplantation (2015), 15

We conducted a questionnaire survey of the 565 European Society for Blood and Marrow Transplantation centers to analyze the outcome of allogeneic hematopoietic stem cell transplantation (alloSCT) in ... [more ▼]

We conducted a questionnaire survey of the 565 European Society for Blood and Marrow Transplantation centers to analyze the outcome of allogeneic hematopoietic stem cell transplantation (alloSCT) in recipients of solid organ transplantation (SOT). We investigated 28 patients with malignant (N=22) or nonmalignant diseases (N=6), who underwent 31 alloSCT procedures: 12 after kidney, 13 after liver, and three after heart transplantation. The incidence of solid organ graft failure at 60 months after first alloSCT was 33% (95% confidence interval [CI], 16–51%) for all patients, 15% (95% CI, 2–40%) for liver recipients, and 50% (95% CI, 19–75%) for kidney recipients (p = 0.06). The relapse rate after alloSCT (22%) was low following transplantation for malignant disorders, despite advanced stages of malignancy. Overall survival at 60 months after first alloSCT was 40% (95% CI, 19–60%) for all patients, 51% (95% CI, 16–86%) for liver recipients, and 42% (95% CI, 14–70%) for kidney recipients (p = 0.39). In summary, we show that selected SOT recipients suffering from hematologic disorders may benefit from alloSCT and experience enhanced long-term survival without loss of organ function. [less ▲]

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See detailSafety and efficacy of azacitidine in Belgian patients with high-risk myelodysplastic syndromes, acute myeloid leukaemia, or chronic myelomonocytic leukaemia: results of a real-life, non-interventional post-marketing survey
Beguin, Yves ULg; Selleslag, Dominik; Meers, Stef et al

in Acta Clinica Belgica (2015), 70

Objectives: We evaluated azacitidine (VidazaH) safety and efficacy in patients with myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), and chronic myelomonocytic leukaemia (CMML), in a real ... [more ▼]

Objectives: We evaluated azacitidine (VidazaH) safety and efficacy in patients with myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), and chronic myelomonocytic leukaemia (CMML), in a real-life setting. Treatment response, dose, and schedule were assessed. Methods: This non-interventional, post-marketing survey included 49/50 patients receiving azacitidine at 14 Belgian haematology centres from 2010–2012. Treatment-emergent adverse events (TEAEs), including treatment-related TEAEs, and serious TEAEs (TESAEs) were recorded throughout the study. Treatment response [complete response (CR), partial response (PR), haematological improvement (HI), stable disease (SD), treatment failure (TF)) and transfusion-independence (TI) were evaluated at completion of a 1-year observation period (1YOP) or at treatment discontinuation, and overall survival (OS), at study conclusion. Results: The median age of patients was 74.7 (range: 43.9–87.8) years; 69.4% had MDS, 26.5% had primary or secondary AML, and 4.1% had CMML. Treatment-related TEAEs, grade 3–4 TEAEs, and TESAEs were reported in 67.3%, 28.6%, and 18.4% of patients, respectively. During 1YOP, patients received a median of 7 (1–12) treatment cycles. Treatment response was assessed for 38/49 patients. Among MDS and CMML patients (n529), 41.4% had CR, PR, or HI, 41.4% had SD, and 17.2% had TF. Among AML patients (n59), 44.4% had CR or PR, 33.3% had SD, and 22.2% had TF. TI was observed in 14/32 (43.8%) patients who were transfusion-dependent at baseline. Median (95% confidence interval) OS was 490 (326–555) days; 1-year OS estimate was 0.571 (0.422–0.696). Conclusions: Our data support previous findings that azacitidine has a clinically acceptable safety profile and shows efficacy. [less ▲]

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See detailError analysis of generalized-alpha Lie group time integration methods for constrained mechanical systems
Arnold, Martin; Bruls, Olivier ULg; Cardona, Alberto

in Numerische Mathematik (2015), 129(1), 149-179

Generalized-alpha methods are very popular in structural dynamics. They are methods of Newmark type and combine favourable stability properties with second order convergence for unconstrained second order ... [more ▼]

Generalized-alpha methods are very popular in structural dynamics. They are methods of Newmark type and combine favourable stability properties with second order convergence for unconstrained second order systems in linear spaces. Recently, they were extended to constrained systems in flexible multibody dynamics that have a configuration space with Lie group structure. In the present paper, the convergence of these Lie group methods is analysed by a coupled one-step error recursion for differential and algebraic solution components. It is shown that spurious oscillations in the transient phase result from order reduction that may be avoided by a perturbation of starting values or by index reduction. Numerical tests for a benchmark problem from the literature illustrate the results of the theoretical investigations. [less ▲]

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See detailSafety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes.
Scheen, André ULg

in Expert opinion on drug safety (2015), epub

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy a growing place in the armamentarium of drugs used for the management of hyperglycemia in type 2 diabetes, although some safety ... [more ▼]

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy a growing place in the armamentarium of drugs used for the management of hyperglycemia in type 2 diabetes, although some safety concerns have been raised in recent years. Areas covered: An updated review providing an analysis of available safety data (meta-analyses, randomized controlled trials, observational cohort and case-control studies and pharmacovigilance reports) with five commercialized DPP-4 inhibitors (sitagliptin, vildagliptin, saxagliptin, alogliptin, linagliptin). A special focus is given to overall safety profile; pancreatic adverse events (AEs) (acute pancreatitis, pancreatic cancer); overall cardiovascular safety (myocardial infarction and stroke); congestive heart failure concern and finally, safety in special populations (elderly, renal impairment). Expert opinion: The good tolerance/safety profile of DPP-4 inhibitors has been largely confirmed, including in more fragile populations (elderly, renal impairment) with almost no increased risk of infection or gastrointestinal AEs, no weight gain and a minimal risk of hypoglycemia. Although an increased risk of acute pancreatitis and pancreatic cancer was suspected, the complete set of available data appears reassuring so far. Cardiovascular safety of DPP-4 inhibitors has been proven but an unexpected increased risk of heart failure has been reported which should be confirmed in ongoing trials and better understood. Further postmarketing surveillance is recommended. [less ▲]

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See detailDevelopment and validation of the French version of a tool assessing patient's expectations in lower limb osteoarthritis
NEUPREZ, Audrey ULg; Delcour, JP; Fatemi, F et al

in Journal of Orthopaedics (2015), 12

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See detailJean-Marie KAJDANSKI, Pain gris, 2014.
Baiwir, Esther ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2015), (1/2015), 13-14

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See detailDe Bruxelles I à Bruxelles Ibis - Retouches aux règles de compétence
Boularbah, Hakim ULg

in Journal des Tribunaux (2015)

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See detailBridging Space Weather to Planetary Environments
Plainaki; Milillo; Andriopoulou et al

Conference (2015)

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See detailP. Carruthers, "Pour une théorie dispositionnelle de la pensée d'ordre supérieur"
Dewalque, Arnaud ULg

in Dewalque, Arnaud; Gauvry, Charlotte (Eds.) Conscience et Représentation. Controverses récentes en philosophie de l'esprit (2015)

Traduction française du célèbre chapitre de Peter Carruthers, "HOP over FOR, HOT Theory". L'auteur y soutient que les théories représentationnelles de premier ordre (Dretske, Tye, et alii) et les théories ... [more ▼]

Traduction française du célèbre chapitre de Peter Carruthers, "HOP over FOR, HOT Theory". L'auteur y soutient que les théories représentationnelles de premier ordre (Dretske, Tye, et alii) et les théories actualistes de la pensée d'ordre supérieur (e.g., Rosenthal) se heurtent à deux sérieuses difficultés: l'incapacité à rendre compte des concepts d'expérience recognitionnels et l'incapacité à expliquer pourquoi certains états sont phénoménalement conscients et d'autres non. P. Carruthers introduit et défend une théorie alternative, d'après laquelle un état mental est phénoménalement conscient si et seulement s'il est mis à la disposition d'une pensée d'ordre supérieur possible. Cette théorie est baptisée théorie dispositionnelle de la pensée d'ordre supérieur ou "théorie du double contenu". [less ▲]

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