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See detailMicroRNA Targeting of CoREST controls polarization of migrating cortical neurons
Volvert; Prévot, Pierre-Paul; Close, Pierre ULg et al

in Cell Reports (2014), 7(4), 1168-83

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See detailImplementation of a non-orthogonal constitutive model for the finite element simulation of textile composite draping
Pierce, Robert S; Falzon, Brian G; Thompson, Mark C et al

in Applied Mechanics and Materials (2014), 553

In the pursuit of producing high quality composite aircraft structures at a low cost, out-of-autoclave manufacturing processes for textile reinforcements are being simulated with increasing accuracy. This ... [more ▼]

In the pursuit of producing high quality composite aircraft structures at a low cost, out-of-autoclave manufacturing processes for textile reinforcements are being simulated with increasing accuracy. This paper focuses on the continuum-based, finite element modelling of textile composites as they deform during the draping process. A non-orthogonal constitutive model tracks yarn orientations within a material subroutine developed for Abaqus/Explicit, resulting in the realistic determination of fabric shearing and material draw-in. Supplementary material characterisation was experimentally performed in order to define the tensile and non-linear shear behaviour accurately. The validity of the finite element model has been studied through comparison with similar research in the field and the experimental lay-up of carbon fibre textile reinforcement over a tool with double curvature geometry, showing good agreement. [less ▲]

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See detailToggling a genetic switch using reinforcement learning
Sootla, Aivar; Strelkowa, Natalja; Ernst, Damien ULg et al

in Proceedings of the 9th French Meeting on Planning, Decision Making and Learning (2014, May)

In this paper, we consider the problem of optimal exogenous control of gene regulatory networks. Our approach consists in adapting an established reinforcement learning algorithm called the fitted Q ... [more ▼]

In this paper, we consider the problem of optimal exogenous control of gene regulatory networks. Our approach consists in adapting an established reinforcement learning algorithm called the fitted Q iteration. This algorithm infers the control law directly from the measurements of the system’s response to external control inputs without the use of a mathematical model of the system. The measurement data set can either be collected from wet-lab experiments or artificially created by computer simulations of dynamical models of the system. The algorithm is applicable to a wide range of biological systems due to its ability to deal with nonlinear and stochastic system dynamics. To illustrate the application of the algorithm to a gene regulatory network, the regulation of the toggle switch system is considered. The control objective of this problem is to drive the concentrations of two specific proteins to a target region in the state space. [less ▲]

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See detailThree North American Mystery Tales
Dechêne, Antoine ULg

Conference (2014, May)

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See detailHigh resolution saturated hydraulic conductivity logging of friable to poorly indurated borehole cores using air permeability measurements
Rogiers, Bart; Winters, P.; Huysmans, Marijke et al

in Hydrogeology Journal (2014)

Saturated hydraulic conductivity (Ks) is one of the most important parameters determining groundwater flow and contaminant transport in both unsaturated and saturated porous media. This paper investigates ... [more ▼]

Saturated hydraulic conductivity (Ks) is one of the most important parameters determining groundwater flow and contaminant transport in both unsaturated and saturated porous media. This paper investigates the hand-held air permeameter technique for high resolution hydraulic conductivity determination on borehole cores using a spatial resolution of ~0.05 m. We test the suitability of such air permeameter measurements on friable to poorly indurated sediments to improve the spatial prediction of classical laboratory based Ks measurements obtained at a much lower spatial resolution (~2 m). About 368 Ks measurements were made on ~350 m of borehole cores originating from the Campine basin, Northern Belgium, while ~5230 air permeability measurements were performed on the same cores. The heterogeneity in sediments, ranging from sand to clayey sand with distinct clay lenses, resulted in a Ks range of seven orders of magnitude. Cross-validation demonstrated that using air permeameter data as secondary variable and laboratory based Ks measurements as primary variable increased performance from R2 = 0.35 for ordinary kriging (laboratory Ks only) to R2 = 0.61 for co-kriging. Due to the large degree of small-scale variability detected by the air permeameter, the spatial granularity in the predicted laboratory Ks also increases drastically. The separate treatment of Kh and Kv revealed considerable anisotropy in certain lithostratigraphical units, while others where clearly isotropic at the sample scale. Air permeameter measurements on borehole cores provide a cost-effective way to improve spatial predictions of traditional laboratory based Ks. [less ▲]

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See detailProjected inhibition of platelet aggregation with ticagrelor twice daily vs. clopidogrel once daily based on patient adherence data (the TWICE project)
Vrijens, Bernard ULg; Claeys, M.J.; LEGRAND, Victor ULg et al

in British Journal of Clinical Pharmacology (2014), 77(5), 746-755

Abstract Aim Twice daily dosing is often perceived as inferior to once daily dosing due to a higher likelihood of missing a dose. However, more important is the extent to which drug action is maintained ... [more ▼]

Abstract Aim Twice daily dosing is often perceived as inferior to once daily dosing due to a higher likelihood of missing a dose. However, more important is the extent to which drug action is maintained when doses are delayed or missed. We compared the estimated inhibition of platelet aggregation (eIPA) for ticagrelor twice daily and clopidogrel once daily, based on their pharmacokinetic/ pharmacodynamic relationships and patient dosing history data. Methods Drug dosing histories of 5014 patients prescribed cardiovascular medications (primarily antihypertensive medicines) were extracted from an electronically compiled dosing history database. eIPA levels were simulated for 677 twice daily and 677 once daily dosing histories over a 30 day period, based on published onset/offset models for ticagrelor and clopidogrel IPA characteristics. Results While many patients treated twice daily missed at least one dose in 30 days, only 25.7% missed two consecutive doses. By comparison, 46.8% of patients treated once daily missed at least one dose. Simulations based on patient adherence over time showed that the average mean eIPA for ticagrelor twice daily remained significantly higher than for clopidogrel once daily (81.1% vs. 55.0%, P < 0.001). Ticagrelor twice daily patients had an eIPA below 10% for 0.20% of the 30 day period compared with 2.05% for clopidogrel once daily (P = 0.0001). Conclusions The projected level of platelet inhibition remained higher for ticagrelor twice daily than clopidogrel once daily, mainly due to the higher eIPA level achieved with ticagrelor and the relatively low likelihood of missing two consecutive twice daily doses. This modelling and simulation study suggests a therapeutic benefit of ticagrelor over clopidogrel when taking into account the most common dosing omissions. © 2013 The British Pharmacological Society. [less ▲]

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See detailLa spectroscopie proche infrarouge, une technique non destructive dans la lutte contre la contrefaçon des médicaments
Mbinze Kindenge, Jérémie ULg; Kalenda Tshilombo, Nicodème; Chavez, Pierre-François ULg et al

in Spectra Analyse (2014), 43

Near infrared spectroscopy is a very promising and expanding analytical technique. It has to be noted that this technique is becoming more used in the pharmaceutical field for the quality control of ... [more ▼]

Near infrared spectroscopy is a very promising and expanding analytical technique. It has to be noted that this technique is becoming more used in the pharmaceutical field for the quality control of products. Indeed near infrared spectroscopy allows to perform fast, non-destructive, versatile analysis of the sample and minimization of the sample preparation. Based on those advantages, this spectroscopic method is one of the first reliable analytical techniques for fighting against counterfeit medicines. [less ▲]

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See detailTowards a real time release approach for manufacturing tablets using NIR spectroscopy
Pestieau, Aude ULg; Krier, Fabrice ULg; Thoorens, Grégory et al

in Journal of Pharmaceutical & Biomedical Analysis (2014), 98

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See detailStratégies analytiques pour la détection de contrefaçons de médicaments pour la dysfonction érectile
Sacre, Pierre-Yves ULg; Deconinck, Eric; Marini Djang'Eing'A, Roland ULg et al

in Spectra Analyse (2014), 43

Erectile dysfunction drugs are among the most counterfeit drug classes in industrialized countries. To fight against this plague, several analytical approaches are available for control laboratories. The ... [more ▼]

Erectile dysfunction drugs are among the most counterfeit drug classes in industrialized countries. To fight against this plague, several analytical approaches are available for control laboratories. The present article reviews the main used techniques and concludes presenting a general strategy for the detection and handling of drug counterfeits. [less ▲]

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See detailLutter contre le fléau des médicaments contrefaits
Rudaz, Serge; Hubert, Philippe ULg

in Spectra Analyse (2014), 298

Editorial

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See detailResilience to Flooding - Draft Building Code
Clarkson, John; Sullican, David; Braun, Kenton et al

in PIANC Yearbook 2013 (2014)

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See detailWork-home interference and well-being: A cross-lagged analysis.
Babic, Audrey ULg; Stinglhamber, Florence; Barbier, Marie ULg et al

Poster (2014, May)

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See detailLa crise financière 2007-2008
Artige, Lionel ULg

Learning material (2014)

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See detailGestion active d’un réseau de distribution d’électricité : formulation du problème et benchmark
Gemine, Quentin ULg; Ernst, Damien ULg; Cornélusse, Bertrand ULg

in Proceedings des 9èmes Journées Francophones de Planification, Décision et Apprentissage (2014, May)

Afin d’opérer un réseau de distribution d’électricité de manière fiable et efficace, c’est-à-dire de respecter les contraintes physiques tout en évitant des coûts de renforcement prohibitifs, il devient ... [more ▼]

Afin d’opérer un réseau de distribution d’électricité de manière fiable et efficace, c’est-à-dire de respecter les contraintes physiques tout en évitant des coûts de renforcement prohibitifs, il devient nécessaire de recourir à des stratégies de gestion active du réseau. Ces stratégies, rendues nécessaires notamment par l’essor de la production distribuée, reposent sur des politiques de contrôle à court-terme du niveau de puissance des dispositifs producteurs ou consommateurs d’électricité. Alors qu’une solution simple consisterait à moduler à la baisse la production des générateurs, il paraît néan- moins plus intéressant de déplacer la consommation aux moments adéquats afin d’exploiter au mieux les sources d’énergie renouvelables sur lesquelles reposent généralement ces générateurs. Un tel moyen de contrôle introduit néanmoins un couplage temporel au problème, menant à un problème d’optimisation non-linéaire, séquentiel sous incertitude et à variables mixtes. Afin de favoriser la recherche dans ce domaine très complexe, nous proposons une formalisation générique du problème de ges- tion active d’un réseau de distribution moyenne tension (MT). Plus spécifiquement, cette formalisa- tion se présente sous la forme d’un processus de décision markovien. Dans cette article, nous pré- sentons également une spécification de ce modèle décisionnel à un réseau de 75 noeuds et pour un ensemble de services de modulation donnés. L’instance de test qui en résulte est disponible à l’adresse http://www.montefiore.ulg.ac.be/~anm/ et a pour objectif de mesurer et de comparer les performances des techniques de résolution qui seront développées. [less ▲]

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See detailL'image ou le déterminant de nouvelles modalités du savoir historique
Servais, Amandine ULg

Scientific conference (2014, May)

Les diverses observations réalisées dans le cadre d’une enquête sur les nouveaux usages historiens des images montrent que ces dernières ne sont pas seulement pourvoyeuses de nouveaux objets. En effet ... [more ▼]

Les diverses observations réalisées dans le cadre d’une enquête sur les nouveaux usages historiens des images montrent que ces dernières ne sont pas seulement pourvoyeuses de nouveaux objets. En effet, elles constituent un embrayeur de la connaissance ; elles offrent un modèle d’intelligibilité. Dès lors, mon hypothèse est que l’image détermine de nouvelles modalités du savoir historique. Afin d’éprouver mon hypothèse, j’étudierai un cas concret : l’œuvre d’Alphonse DUPRONT. Dans les travaux de DUPRONT, l’image ne constitue pas la problématique mais est un matériau privilégié. C’est elle qui sert, au mieux, le dessein historien, en l’occurrence l’anthropologie historique d’une expérience de religion, expérience inscrite au cœur du vécu social. Une déconstruction du texte dupronien révèle que l’image est convoquée, systématiquement, pour mesurer le temps long des phénomènes, leur origine, leur devenir, leur disparition, leur maintien sous l’une ou l’autre forme, de l’une ou l’autre manière. L’image révèle donc efficacement le vécu collectif que vise DUPRONT. Selon sa perspective, le passé ne peut être réduit à la succession linéaire des causes et des effets ; il faut considérer le temps long, transcendant les siècles, au cours duquel les phénomènes surviennent, se terrent et rejaillissent. (Cette conception originale de la longue durée a déjà été remarquée. Cf. surtout HERMAN DE FRANCESCHI, « L’irruption de l’événement dans le temps de l’Histoire. Rythmique événementielle et longue durée selon Alphonse Dupront (1905-1990) », Revue historique, 659 (juillet 2011), p. 611-636.) DUPRONT entend donc montrer le travail du « temps survivant ». Pour ce faire, DUPRONT préconise une démarche originale : une « induction explorante ». À une perspective particulière correspond une méthode particulière qui passe par une approche tout aussi singulière du document. En effet, l’historien examine un « matériau objectif » où s’entremêlent Passé et Présent. Parmi les sources, c’est l’image qui, dans la démonstration de DUPRONT, révèle le plus parfaitement la longue durée des événements. Ainsi, sont étroitement intriquées les catégories du temps (DUPRONT, on l’a vu, développe une conception particulière de la longue durée) et de l’image (matériau ad hoc pour réaliser le projet de l’historien). Il me semble que cette intrication des catégories vient de ce que la définition du temps (longue durée), ici, engendre une conception de l’événement (c’est-à-dire du vécu qu’étudie l’historien) s’accordant à une certaine définition de l’image (l’image entendue comme agrégat d’hétérogènes et, par-là, possédant un potentiel d’actualisation) ; dès lors, événement et image partagent une même propriété, celle d’être actualisables. Cette contiguïté catégorielle fonde le modèle heuristique dupronien. En cela, sans être l’objet de l’enquête, l’image occupe une place prépondérante. Elle est un embrayeur du savoir ; elle offre un modèle d’intelligibilité. [less ▲]

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See detailIs isokinetic eccentric exercise dangerous for the heart?
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; LAURENT, Terry ULg et al

in Isokinetics & Exercise Science (2014), 22(2), 131-136

BACKGROUND: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in order ... [more ▼]

BACKGROUND: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in order to perform these very intensive exercises; otherwise an acute myocardial dysfunction could theoretically appear in predisposed patients. OBJECTIVE: Our study aimed to observe the cardiovascular impact of a maximal intense isokinetic eccentric exercise performed by a population of sedentary young men. METHODS: Resting and post-exercise (just after, 3 hours and 24 hours after the exercise) blood samples were taken from 12 young male sedentary healthy subjects. These subjects performed an intense maximal eccentric isokinetic exercise of the quadriceps muscle.We evaluated markers of cardiovascular risk (troponin I, highly sensitive troponin T, NT-proBNP,myoglobin), of inflammation (hsCRP) and of oxidative stress (myeloperoxydase, lipidic peroxides, reduced and oxidized glutathione). RESULTS: The following observations were made: no significant increase in cardiac (NT-proBNP, troponins) or inflammation (hsCRP) biomarkers; a significant increase in myoglobin, myeloperoxidase, lipidic peroxides, oxidised glutathione just after the exercise. CONCLUSIONS: No modification in cardiac biomarkers were observed after the maximal eccentric isokinetic exercise. We were thus able to prove that the exercise could be performed without any risk to cardiac function in young sedentary subjects. However, a significant level of oxidative stress was induced by this exercise. [less ▲]

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See detailThe International Relations of the European Union
Santander, Sébastian ULg

Learning material (2014)

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