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See detailHow light and occupational therapy intervention could fight some psychogeriatric symptoms
Maggi, Patrick ULg; Bassain, Fatima; Gosset, Christiane ULg et al

Conference (2014, November 27)

Purpose: Aggregated results of systematic reviews separately show how light used as a treatment and some occupational therapy interventions could have a positive impact on psychobehavioural disorders in ... [more ▼]

Purpose: Aggregated results of systematic reviews separately show how light used as a treatment and some occupational therapy interventions could have a positive impact on psychobehavioural disorders in older people. Since the beginning of June 2014 the Walloon Government has been financing a project which consists of a non-pharmacological approach that combines light and occupational therapy for a psychogeriatric population with specific symptoms: spatial and temporal disorientations, apathy, depression, agitation, anxiety, confusion and circadian disorder. The objective of this abstract is to expose the assumptions that the combination of two different light devices and one specific occupational therapy program could have an impact on the different symptoms of a psychogeriatric population. Methods: To build our hypothesis, two literature reviews have been achieved. The first one concerning the use of light as therapy gathered 30 studies while the other one about occupational therapy activities collected 35 articles. Results: Despite of a heterogeneity between studies dealing with light and occupational therapy, the combination of these two non-pharmacological interventions might fight the depressive syndrome, reduce the temporal disorientation thanks to a regularity in the period of activity, restore the circadian rhythm and so reduce some troubles that can be linked to them: sleep disorder, risk of fall, apathy, agitation, behavioural and cognitive troubles (attention, concentration). Moreover, one of the two light devices used which can modulate the light intensity according to the rooms might reduce the spatial disorientation if it’s employed as a landmark. Conclusions: Based on literature reviews and our experience into this field it’s seems that a non-pharmacological approach involving light and occupational therapy intervention could have a positive effect on symptoms of psychogeriatric population. In admitting that those effects are becoming true after experimentation and analyses, we can also expect an improvement of the quality of life. [less ▲]

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See detailL’animation théâtrale comme présence sociale
Brahy, Rachel ULg

Conference (2014, November 27)

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See detailLa sociologie par la littérature : une approche transdisciplinaire
Ledent, David ULg

Conference (2014, November 27)

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See detailRole of the polyQ length and non-polyQ regions during the aggregation process into amyloid fibrils of model polyQ proteins
Huynen, Céline ULg; Willet, Nicolas ULg; Buell, Alexander K et al

Poster (2014, November 26)

Nine neurodegenerative disorders, referred to as polyglutamine diseases and including Huntington’s disease, are associated with the abnormal expansion of a polyglutamine tract inside nine unrelated ... [more ▼]

Nine neurodegenerative disorders, referred to as polyglutamine diseases and including Huntington’s disease, are associated with the abnormal expansion of a polyglutamine tract inside nine unrelated proteins. This polyQ expansion is thought to be the major determinant in the development of neurotoxicity, triggering protein aggregation into amyloid fibrils. A large body of evidence however suggests that non-polyQ regions modulate the aggregation process triggered by polyQ expansions. The interplay between the polyQ tract and non-polyQ regions is complex and still not fully understood. In order to better understand it, we previously designed and characterized model polyQ proteins made of the beta-lactamase BlaP with 23, 30, 55 and 79Q inserted at position 197 or 216. Our first results had indicated that our model is relevant to study polyQ aggregation since it recapitulates the aggregation properties of polyQ disease-associated proteins: there is a Q-threshold for the spontaneous formation of amyloid fibrils in solution, and above the threshold, the longer the polyQ, the faster the aggregation. Moreover, the structure of BlaP and the position of insertion of the polyQ tract influence their aggregation properties in solution. This work aims to better understand, at the molecular level, (i) the precise role of the polyQ length (23, 30, 55, 61, 67, 73 and 79Q), (ii) the conformation of the host protein (native or unfolded BlaP), (iii) the location of the polyQ tract within BlaP (197 or 216), (iv) the flexibility of the polyQ flanking sequences, and (v) the origin of constraints applied by BlaP to the inserted polyQ tract (at its N- or C-terminal end) on the structural, thermodynamic and aggregation properties of BlaP-polyQ chimeras, using a wide range of biophysical techniques (e.g., spectroscopy methods, quartz crystal microbalance, atomic force microscopy and dynamic light scattering). The effect on the aggregation properties will be determined on the spontaneous aggregation into amyloid fibrils in solution, and on the nucleation and on the elongation steps of amyloid fibril formation. For this purpose, new chimeras containing 61, 67 and 73Q at position 197, or 55Q inserted at position 197 in between two different protease’s cleavage sites, that are relatively flexible, will be moreover created. Our results first demonstrate that the spontaneous aggregation into amyloid fibrils in solution is correlated to the polyQ length with an exponential growth function, and that the elongation rate is linearly correlated to the polyQ length, independently of the protein context (i.e., conformation of BlaP, and/or location of the polyQ tract, and/or polyQ peptides inserted or not within BlaP). However, the location of the polyQ tract inside BlaP, and/or its conformational state, and/or the flexibility of polyQ flanking sequences, and/or the origin of constraints applied to the polyQ tract drastically influence the ability of a polyQ tract to trigger the nucleation and/or the elongation step of amyloid fibrils (variation in the Q-threshold and in the absolute rate of both steps). Altogether, our results suggest that non-polyQ regions constitute an additional potential therapeutic target, more specific than drugs targeting the polyQ sequence, to interfere with the nucleation and/or the elongation of amyloid fibrils, associated to neurotoxicity. A possible drug could be constituted by a ligand specific to non-polyQ regions of disease-associated proteins, which further increases the constraints applied to the polyQ expansion to prevent the disease onset and/or progression. [less ▲]

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See detailClimat et gaz à effet de serre: récentes évolutions constatées
Ozer, Pierre ULg

Scientific conference (2014, November 26)

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See detailRadiotherapy : Controversy
Beckers, Albert ULg

Scientific conference (2014, November 26)

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See detailThe Eurogypsum list of biodiversity indicators: a tool to increase biodiversity capacity in the gypsum industry.
Pitz, Carline ULg; Mahy, Grégory ULg

Conference given outside the academic context (2014)

The resulting framework contains eleven indicators which are the most acceptable set of indicators for all the stakeholders. It answers to European legislation and strategies for biodiversity. It is ... [more ▼]

The resulting framework contains eleven indicators which are the most acceptable set of indicators for all the stakeholders. It answers to European legislation and strategies for biodiversity. It is intended to improve sustainability in the quarries and to help managing biodiversity, to allow setting up of appropriate reporting systems. The aim is to maintain the biodiversity status of the gypsum quarries. It is a flexible framework adaptable given the local context of each gypsum quarry in order to prove if a No Net Loss has been reached at a quarry’s scale. [less ▲]

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See detailHigh-throughput synthesis of functional oxide films
Dhanapal, Pravarthana ULg

Doctoral thesis (2014)

Epitaxy of metal oxides is of great interest since it provides a way to obtain desired novel properties for the applications such as electronics and energy. However, earlier epitaxy research's have been ... [more ▼]

Epitaxy of metal oxides is of great interest since it provides a way to obtain desired novel properties for the applications such as electronics and energy. However, earlier epitaxy research's have been restricted because of the limited range of compositions and low-index of commercially available single crystal substrates. Consequently, novel epitaxy synthesis methods need to be developed in order to go beyond the present demands of of single crystal substrates in terms of phase, composition, size, orientation and symmetry. In this research work, we have developed a high-throughput synthesis process, called combinatorial substrate epitaxy (CSE), where an oxide film is grown epitaxially on a polycrystalline substrate. As a proof-of-concept, we firstly fabricated Ca3Co4O9 films on Al2O3 ceramics. Films have a good local epitaxial registry, and the Seebeck coefficient is about 170 µV/K at 300 K. High quality BiFeO3/La0.7Sr0.3MnO3 thin film heterostructures were secondly deposited on dense LaAlO3 ceramics prepared by spark plasma sintering. Piezoforce microscopy was used to confirm the local ferroelectric properties. Thirdly, we investigate the growth of of metastable monoclinic Dy2Ti2O7 epitaxial films on polycrystalline La2Ti2O7 substrates. We conclude that CSE approach opens the way towards unexpected electronic properties in oxide films. [less ▲]

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See detailPattern Matching & Image Registration
Latour, Philippe ULg

Learning material (2014)

This document is an overwiew of the objectives, methods and applications of pattern matching and image registration. Both pixel-based and features-based methods are reviewed and compared. Some ... [more ▼]

This document is an overwiew of the objectives, methods and applications of pattern matching and image registration. Both pixel-based and features-based methods are reviewed and compared. Some applications to machine vision (electronic component manufacturing) are described. [less ▲]

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See detailAllergies alimentaires
GADISSEUR, Romy ULg

Conference (2014, November 26)

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See detailIn vitro hemocompatibility assessment of Near-IR-Emitting Ag2S Quantum Dots (QD)
Grandfils, Christian ULg; Hocaoglu, I.; Demir, F. et al

in Proceeding of the Nanobiotechnology International Workshop (2014, November 26)

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See detailUse of 13C-NMR in structural elucidation of polysaccharides: case of locust bean gum
Gillet, Sébastien ULg; Aguedo, Mario ULg; Blecker, Christophe ULg et al

Poster (2014, November 25)

Locust bean gum (LBG) galactomannans are polysaccharides consisting of a β-(1→4) D-mannopyranosyl backbone substituted to varying degrees in α-(1→6) with single D-galactopyranosyl residues. This basic ... [more ▼]

Locust bean gum (LBG) galactomannans are polysaccharides consisting of a β-(1→4) D-mannopyranosyl backbone substituted to varying degrees in α-(1→6) with single D-galactopyranosyl residues. This basic structure is the same for all galactomannans (Fig. 2). However, when locust bean gum is extracted at different temperatures, the generated fractions exhibit different properties in aqueous solution (viscosity, viscoelasticity, gel formation, thermohydrolysis resistance, etc.). This means that there are differences within the fine structure of the polymers (although the basic structure is the same). Analysis of [13C]-NMR spectra of galactomannans, in combination with other techniques, can provide capital information about fine structural elucidation of the polymers. The method specifies the distribution of lateral galactosyls along the main chain of mannans. Two fractions extracted from locust bean gum at 25 and 80 °C (respectively GM25 and GM80) were comparatively studied by [13C]-NMR. Mannosyls/Galactosyls (M/G) ratios can be determined by considering the intensities of C-1 mannose and galactose signals in [13C]-NMR spectra. This method provides results relatively close to those obtained by GC-MS analysis. Spectra also showed that resonance from C4 of D-mannose residues were split, in evident dependence upon the nearest-neighbor probabilities (“diad frequencies”) of D-galactosyl groups along the mannan chains (Fig. 2). Diad frequencies were obtained by integrating C4(Man) peak areas. F11, F21/F12 and F22 gave respectively the di-, mono- or non-substituted mannose pairs proportions. High percentages of F11 and F22 therefore indicate a more non-homogeneous distribution of lateral galactosyls along the polysaccharide backbone as observed for GM80. The percentages of total lateral substituents obtained by C4(Man) peak analysis [F11 + (F21 or F12)/2] were fairly well correlated with M/G ratios. Splitting of the C-6 substituted D-mannose resonance provides, therefore the basis for determining the next-nearest-neighbor probabilities (triad frequencies) (Fig. 2). However, the spectrum is often not sufficiently resolved to accurately quantify and interpret the results. [less ▲]

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See detailGuides d'architecture moderne et contemporaine en Wallonie et à Bruxelles
Charlier, Sébastien ULg; Moor, Thomas

Conference (2014, November 25)

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