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See detailAssessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography.
Gosseries, Olivia ULg; Thibaut, Aurore ULg; Boly, Mélanie ULg et al

in Annales Françaises d'Anesthésie et de Réanimation (2014)

Thanks to advances in medical care, an increased number of patients recover from coma. However, some remain in vegetative/unresponsive wakefulness syndrome or in a minimally conscious state. Detection of ... [more ▼]

Thanks to advances in medical care, an increased number of patients recover from coma. However, some remain in vegetative/unresponsive wakefulness syndrome or in a minimally conscious state. Detection of awareness in severely brain-injured patients is challenging because it relies on behavioral assessments, which can be affected by motor, sensory and cognitive impairments of the patients. Other means of evaluation are needed to improve the accuracy of the diagnosis in this challenging population. We will here review the different altered states of consciousness occurring after severe brain damage, and explain the difficulties associated with behavioral assessment of consciousness. We will then describe a non-invasive technique, transcranial magnetic stimulation combined with high-density electroencephalography (TMS-EEG), which has allowed us to detect the presence or absence of consciousness in different physiological, pathological and pharmacological states. Some potential underlying mechanisms of the loss of consciousness will then be discussed. In conclusion, TMS-EEG is highly promising in identifying markers of consciousness at the individual level and might be of great value for clinicians in the assessment of consciousness. [less ▲]

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See detailEffect of zolpidem in chronic disorders of consciousness: a prospective open-label study.
Thonnard, Marie ULg; Gosseries, Olivia ULg; Demertzi, Athina ULg et al

in Functional Neurology (2014)

Zolpidem has been reported as an "awakening drug" in some patients with disorders of consciousness (DOC). We here present the results of a prospective openlabel study in chronic DOC patients. Sixty ... [more ▼]

Zolpidem has been reported as an "awakening drug" in some patients with disorders of consciousness (DOC). We here present the results of a prospective openlabel study in chronic DOC patients. Sixty patients (35±15 years; 18 females; mean time since insult ± SD: 4±5.5 years; 31 with traumatic etiology) with a diagnosis of vegetative state/unresponsive wakefulness syndrome (n=28) or minimally conscious state (n=32) were behaviorally assessed using the Coma Recovery Scale-Revised (CRS-R) before and one hour after administration of 10 mg of zolpidem. At the group level, the diagnosis did not change after intake of zolpidem (p=0.10) and CRS-R total scores decreased (p=0.01). Twelve patients (20%) showed improved behaviors and/or CRS-R total scores after zolpidem administration but in only one patient was the diagnosis after zolpidem intake found to show a significant improvement (functional object use), which suggested a change of diagnosis. However, in this patient, a double-blind placebo-controlled trial was performed in order to better specify the effects of zolpidem, but the patient, on this trial, failed to show any clinical improvements. The present open-label study therefore failed to show any clinically significant improvement (i.e., change of Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study diagnosis) in any of the 60 studied chronic DOC patients. [less ▲]

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See detailFourth Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria
Wybo, Ingrid; Van den Bossche; Soetens, Oriane et al

in Journal of Antimicrobial Chemotherapy (2014), 69

Objectives: To collect recent data on the susceptibility of anaerobes to antimicrobial agents with known activity against anaerobes, and to compare them with results from previous Belgian multicentre ... [more ▼]

Objectives: To collect recent data on the susceptibility of anaerobes to antimicrobial agents with known activity against anaerobes, and to compare them with results from previous Belgian multicentre studies. Methods: Four hundred and three strict anaerobic clinical isolates were prospectively collected from February 2011 to April 2012 in eight Belgian university hospitals. MICs were determined by one central laboratory for 11 antimicro- bial agents using Etest methodology. Results: According to EUCAST breakpoints, .90% of isolates were susceptible to amoxicillin/clavulanate (94%), piperacillin/tazobactam (91%), meropenem (96%), metronidazole (92%) and chloramphenicol (98%), but only 70% and 40% to clindamycin and penicillin, respectively. At CLSI recommended breakpoints, only 71% were sus- ceptible to moxifloxacin and 79% to cefoxitin. MIC50/MIC90 values for linezolid and for tigecycline were 1/4 and 0.5/ 4 mg/L, respectively. When compared with survey data from 2004, no major differences in susceptibility profiles were noticed. However, the susceptibility of Prevotella spp. and other Gram-negative bacilli to clindamycin decreased from 91% in 1993 – 94 and 82% in 2004 to 69% in this survey. Furthermore, the susceptibility of clostridia to moxifloxacin decreased from 88% in 2004 to 66% in 2011 – 12 and that of fusobacteria from 90% to 71%. Conclusions: Compared with previous surveys, little evolution was seen in susceptibility, except a decline in activity of clindamycin against Prevotella spp. and other Gram-negative bacteria, and of moxifloxacin against clostridia. Since resistance was detected to all antibiotics, susceptibility testing of anaerobic isolates is indicated in severe infections to confirm appropriateness of antimicrobial therapy. [less ▲]

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See detailModelling the Holocene migrational dynamics of Fagus sylvatica L. and Picea abies (L.) H. Karst
Lehsten, Lehsten; Dullinger, Stefan; Hülber, Karl et al

in Global Ecology and Biogeography (2014)

Aim: Vegetation dynamics and the competitive interactions involved are assumed to restrict the ability of species to migrate. But in most migration modelling approaches disturbance-driven succession and ... [more ▼]

Aim: Vegetation dynamics and the competitive interactions involved are assumed to restrict the ability of species to migrate. But in most migration modelling approaches disturbance-driven succession and competition processes are reduced to simple assumptions or are even missing. The aim of this study was to test a combination of a migration model and a dynamic vegetation model to estimate the migration of tree species controlled by climate, environment and local species dynamics such as succession and competition. Location: Europe. Methods: To estimate the effect of vegetation dynamics on the migration of European beech and Norway spruce, we developed a post-process migration tool (LPJ-CATS). This tool integrates outputs of the migration model CATS and the dynamic vegetation model LPJ-GUESS. The model LPJ-CATS relies on a linear dependency between the dispersal kernel and migration rate and is based on the assumption that competition reduces fecundity. Results: Simulating potential migration rates with the CATS model, which does not account for competition and disturbance, resulted in mean Holocene migra- tion rates of 435 ± 55 and 330 ± 95 m year−1 for the two species Picea abies and Fagus sylvatica, respectively. With LPJ-CATS, these mean migration rates were reduced to 250 ± 75 and 170 ± 60 m year−1 for spruce and beech, respectively. Moreover, LPJ-CATS simulated migration pathways of these two species that gen- erally comply well with those documented in the palaeo-records. Main conclusions: Our ‘hybrid’ modelling approach allowed for the simulation of generally realistic Holocene migration rates and pathways of the two study species on a continental scale. It suggests that competition can considerably modify spread rates, but also the magnitude of its effect depends on how close climate conditions are to the niche requirements of a particular species. [less ▲]

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See detailToward genomic prediction from whole-genome sequence data: impact of sequencing design on genotype imputation and accuracy of predictions.
Druet, Tom ULg; Macleod, I. M.; Hayes, B. J.

in Heredity (2014), 112(1), 39-47

Genomic prediction from whole-genome sequence data is attractive, as the accuracy of genomic prediction is no longer bounded by extent of linkage disequilibrium between DNA markers and causal mutations ... [more ▼]

Genomic prediction from whole-genome sequence data is attractive, as the accuracy of genomic prediction is no longer bounded by extent of linkage disequilibrium between DNA markers and causal mutations affecting the trait, given the causal mutations are in the data set. A cost-effective strategy could be to sequence a small proportion of the population, and impute sequence data to the rest of the reference population. Here, we describe strategies for selecting individuals for sequencing, based on either pedigree relationships or haplotype diversity. Performance of these strategies (number of variants detected and accuracy of imputation) were evaluated in sequence data simulated through a real Belgian Blue cattle pedigree. A strategy (AHAP), which selected a subset of individuals for sequencing that maximized the number of unique haplotypes (from single-nucleotide polymorphism panel data) sequenced gave good performance across a range of variant minor allele frequencies. We then investigated the optimum number of individuals to sequence by fold coverage given a maximum total sequencing effort. At 600 total fold coverage (x 600), the optimum strategy was to sequence 75 individuals at eightfold coverage. Finally, we investigated the accuracy of genomic predictions that could be achieved. The advantage of using imputed sequence data compared with dense SNP array genotypes was highly dependent on the allele frequency spectrum of the causative mutations affecting the trait. When this followed a neutral distribution, the advantage of the imputed sequence data was small; however, when the causal mutations all had low minor allele frequencies, using the sequence data improved the accuracy of genomic prediction by up to 30%.Heredity advance online publication, 3 April 2013; doi:10.1038/hdy.2013.13. [less ▲]

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See detailL'écosystème d'innovation universitaire de Aalto : une contribution au repérage des acteurs impliqués lors de la phase d'émergence
Froehlicher, Thomas ULg; Barès, Franck

in Management International = International Management = Gestión Internacional (2014), 18(1), 153-165

The aim of this article is to better under- stand how the innovation ecosystem of Aalto University, in Helsinki, Finland, was structured in the early 2000s. Relying on an analysis of secondary data as ... [more ▼]

The aim of this article is to better under- stand how the innovation ecosystem of Aalto University, in Helsinki, Finland, was structured in the early 2000s. Relying on an analysis of secondary data as well as on the principles of a structural analy- sis of the network, we located the actors and their connections over the emergence period of this ecosystem. The results show the coexistence of two spaces organized as socio-cognitive networks able to interact and reinforce each other. A territorialized space, focused on an innovation dynamic built on the convergence strategy of the three university rectors involved at Aalto; and a deterritorialized space built by a community of actors focused on the affir- mation of proposals and ideas to imple- ment new innovation governance practices. [less ▲]

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See detailA climate analysis tool for passive heating and cooling strategies in hot humid climate based on Typical Meteorological Year data sets
Nguyen, Anh Tuan ULg; Reiter, Sigrid ULg

in Energy & Buildings (2014), 68(Part C), 756-763

Through a newly developed climate analysis tool, this paper examines the potential of improving thermal comfort under the climates of Vietnam thanks to passive strategies. A Building climatic chart for ... [more ▼]

Through a newly developed climate analysis tool, this paper examines the potential of improving thermal comfort under the climates of Vietnam thanks to passive strategies. A Building climatic chart for Vietnamese was proposed based on Fanger’s theory [1] and the comfort zone of this chart was then extended by calculating the effects of passive heating and cooling strategies. Typical Meteorological Year weather data are used for extracting and graphically printing of hourly environmental parameters on the psychrometric chart and for climate analysis, subsequently. The limitation and the scope of this method are also specified. The climates of three climatic regions in Vietnam have been used as case studies using all year, seasonal and monthly analysis. The results show that natural ventilation is an effective cooling solution as thermal comfort improvement varies with the climatic zones, increasing from 24.8% in Hanoi, 22.1% in Danang to 32.0% in Hochiminh city. Meanwhile, passive solar heating is only effective under the climate of Hanoi. Direct evaporative cooling also shows great cooling potential for comfort improvement but probable elevated humidity is not expected. Total possible comfort in a year of each location indicates that further climate modification methods are inevitable to achieve comfort during extreme weather conditions, especially in Hanoi. [less ▲]

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See detailGold nanorods with phase-changing polymer corona for remotely near-infrared-triggered drug release
Liu, Ji ULg; Detrembleur, Christophe ULg; Grignard, Bruno ULg et al

in Chemistry : An Asian Journal (2014), 9(1), 275-288

Herein, we report a new drug-delivery system (DDS) that is comprised of a near-infrared (NIR)- light-sensitive gold-nanorod (GNR) core and a phase-changing poly(e-caprolactone)- b-poly(ethylene glycol ... [more ▼]

Herein, we report a new drug-delivery system (DDS) that is comprised of a near-infrared (NIR)- light-sensitive gold-nanorod (GNR) core and a phase-changing poly(e-caprolactone)- b-poly(ethylene glycol) polymer corona (GNR@PCL-b-PEG). The underlying mechanism of the drugloading and triggered-release behaviors involves the entrapment of drug payloads among the PCL crystallites and a heat-induced phase change, respectively. A low premature release of the pre-loaded doxorubicin was observed in PBS buffer (pH 7.4) at 37 °C (<10% of the entire payload after 48 h). However, release could be activated within 30 min by conventional heating at 50 °C, above the Tm of the crystalline PCL domain (43.5 °C), with about 60% release over the subsequent 42 h at 37 °C. The NIR-induced heating of an aqueous suspension of GNR@PCL-b- PEG under NIR irradiation (802 nm) was investigated in terms of the irradiation period, power, and concentrationdependent heating behavior, as well as the NIR-induced shape-transformation of the GNR cores. Remotely NIR-triggered release was also explored upon NIR irradiation for 30 min and about 70% release was achieved in the following 42 h at 37°C, with a mild warming (<4 °C) of the surroundings. The cytotoxicity of GNR@PCL-b-PEG against the mouse fibroblastic-like L929 cell-line was assessed by MTS assay and good compatibility was confirmed with a cell viability of over 90% after incubation for 72 h. The cellular uptake of GNR@PCL-b-PEG by melanoma MEL-5 cells was also confirmed, with an averaged uptake of 1250 ( ± 110) particles cell-1 after incubation for 12 h (50 mg mL-1). This GNR@PCL-b-PEG DDS is aimed at addressing the different requirements for therapeutic treatments and is envisaged to provide new insights into DDS targeting for remotely triggered release by NIR activation. [less ▲]

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See detailL’associationnisme ethnique à l’épreuve du temps : étude de cas. Le Movimiento Asociativo de Emigrantes Españoles en Bélgica
Molina Marmol, Maïté ULg

in Actes des journée d’étude du 10 novembre 2011 « Immigration et troisième âge. Vieillir en migration, constats et solutions pour des populations silencieuses » (2014, January)

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See detailMyocardial expression of cytokines influence postoperative outcome after cardiac surgery for congenital cardiac defects
Sprute, Johanna; Heying, Ruth; Buding, Brigitte et al

Conference (2014, January)

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See detailCardiac malformations in neonates born from mothers with gestational diabetes
Antole, Nathalie; Jacquemart, Caroline; GKIOUGKI, Evangelia ULg et al

Conference (2014, January)

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See detailA vibrotactile P300-based BCI for consciousness detection and communication
Lugo, Zulay; Rodriguez, Javi; Lechner, Alexander et al

in Clinical EEG and Neuroscience : Official Journal of the EEG and Clinical Neuroscience Society (ENCS) (2014)

Brain–computer interface (BCI) has been used for many years for communication in severely disabled patients. BCI based on electrophysiological signals has enabled communication, using auditory or visual ... [more ▼]

Brain–computer interface (BCI) has been used for many years for communication in severely disabled patients. BCI based on electrophysiological signals has enabled communication, using auditory or visual stimuli to elicit event-related potentials (ERPs). The aim of this study was to determine whether patients with locked-in syndrome (LIS) could elicit a P300 wave, using a vibrotactile oddball paradigm for establishing somatosensory BCI-based communication. Six chronic LIS patients performed 2electroencephalography (EEG)-based vibrotactile P300 oddball tasks. After a simple mental counting task of the target stimuli, participants were instructed to answer 5 questions by counting the vibration on either the right wrist for “yes” or the left wrist for “no.” All participants were able to elicit a P300 wave using the vibrotactile oddball paradigm BCI task. In the counting task, 4 patients got accuracies of 100% (average above chance). In the communication task, one patient achieved 100% accuracy (average above chance). We have shown the feasibility of eliciting a P300 response using vibrotactile stimulation in patients with LIS. The present study provides evidence that this approach can be used for EEG-based BCI communications in this patient group. This is the first study to prove the feasibility of a BCI based on somatosensory (vibratory) stimulation in a group of braininjured patients. Furthermore, this approach could be used for the detection of consciousness in non-communicating patients due to severe brain injuries. [less ▲]

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See detailLa gestion communautaire des ressources naturelles à l’Est de la R.D.Congo : expérience de l’UGADEC
Mukulumanya, Magnant; Vermeulen, Cédric ULg; Kalinda, A et al

in Parcs & Réserves (2014), 68(4), 11-15

Les provinces du Nord Kivu et du Maniema, à l’est de la R.D.Congo sont confrontés à la destruction de l’environnement, particulièrement dans les parties des territoires de Walikale, Lubero, Punia et ... [more ▼]

Les provinces du Nord Kivu et du Maniema, à l’est de la R.D.Congo sont confrontés à la destruction de l’environnement, particulièrement dans les parties des territoires de Walikale, Lubero, Punia et Lubutu. Alors que les forêts riches en biodiversité sont importantes tant pour l’Etat du fait de leur valeur économique que pour les communautés locales pour leur développement, les menaces qui pèsent sur ces dernières sont légions. Les plus importantes sont les mines, les guerres, le foncier, la légitimité et la légalité, etc. Face à cette situation, en 1998 les communautés locales de ces territoires ont décidé d’initier un nouveau modèle de gestion communautaire des ressources naturelles par la création de réserves gérées par les populations locales. L’objectif de ce modèle est la gestion de biodiversité associée au développement endogène, conduite par une l’Union des Associations de Conservation de Gorilles pour le Développement Communautaire à l’Est de la R.D.Congo (UGADEC). Quinze ans après le début de cette initiative les résultats sont prometteurs. Des actions de conservation ont été mises en place et un développement rural amorcé. Cependant, pour que la gestion communautaire devienne une réalité, il importe qu’un partenariat durable soit établi entre les différents acteurs liés à la gestion des réserves communautaires de l’est. [less ▲]

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See detailDIRECTED INFORMATION TRANSFER IN SCALP ELECTROENCEPHALOGRAPHIC RECORDINGS: INSIGHTS ON DISORDERS OF CONSCIOUSNESS
Marinazzo, Daniele; Gosseries, Olivia ULg; Boly, Mélanie ULg et al

in Clinical EEG and Neuroscience : Official Journal of the EEG and Clinical Neuroscience Society (ENCS) (2014)

Introduction: The neural mechanisms underlying electrophysiological changes observed in patients with disorders of consciousness following a coma remain poorly understood. The aim of this article is to ... [more ▼]

Introduction: The neural mechanisms underlying electrophysiological changes observed in patients with disorders of consciousness following a coma remain poorly understood. The aim of this article is to investigate the mechanisms underlying the differences in spontaneous electroencephalography between patients in vegetative/unresponsive wakefulness syndrome, minimally conscious state, emergence of the minimally conscious state and age-matched healthy control subjects. <br />Methods: Forty recording of spontaneous scalp electroencephalography were performed in 27 patients who were comatose on admission, and on healthy controls. Multivariate Granger Causality and Transfer Entropy were applied on the data. <br />Results: Distinctive patterns of putative bottlenecks of information were associated to each conscious state. Healthy controls are characterized by a greater amount of synergetic contributions from duplets of variables. <br />Conclusion: A novel set of measures was tested to get a novel insight on the pattern of information transfer in a network of scalp electrodes in patients with disorders of consciousness. [less ▲]

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See detailContribution to the macrophytic typology of the Belgian reference watercourses
Galoux, Daniel; Chérot, Frédéric; Rosillon, Francis ULg et al

in International Journal of Water Sciences (2014)

The objective of the study is to create a typology of macrophytes for the reference watercourses of the Meuse River catchment basin in Wallonia, as a step towards the implementation of the European Water ... [more ▼]

The objective of the study is to create a typology of macrophytes for the reference watercourses of the Meuse River catchment basin in Wallonia, as a step towards the implementation of the European Water Framework Directive. The 50 sites studied are the object of a physicochemical and environmental characterisation followed by a floristic survey (phanerogams, mosses, liverworts, and macroalgae). Six clusters of watercourses with their characteristic species are highlighted by two-way clustering and indicator species. The abundance of phanerogams in some watercourses of the Arden region is not only linked to light intensity but also depends on the degree of slope and the nature of the geological substrate. [less ▲]

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See detailFestival du jeu vidéo indépendant : photographie d'une communauté
Hurel, Pierre-Yves ULg

Article for general public (2014)

Le secteur du jeu vidéo indépendant continue de s'organiser et de s'institutionnaliser. En octobre 2013 avait lieu à Montreuil (France) la deuxième édition de son festival européen : l'European ... [more ▼]

Le secteur du jeu vidéo indépendant continue de s'organiser et de s'institutionnaliser. En octobre 2013 avait lieu à Montreuil (France) la deuxième édition de son festival européen : l'European Independant Games Days (EIGD). Celui-ci se présente comme un cycle de conférences sur deux jours durant lesquels les professionnels parlent aux professionnels. L'occasion pour nous de relever quelques débats qui animent le milieu. [less ▲]

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See detailMigrations congolaises (RDC) en Belgique et postcolonialismes
Demart, Sarah ULg

in La lutte contre les discriminations au regard de l’histoire et de la mémoire coloniales : état des lieux (2014, January)

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