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See detailADAM28 - Generation of a conditional ADAM28 knock-out mouse Implication of ADAM28 in metastasis dissemination
Gérard, Catherine ULg; Rocks, Natacha ULg; Carnet, Oriane ULg et al

Poster (2016, October)

Introduction: ADAMs (a disintegrin and metalloproteinase) and ADAMTS proteinases (a disintegrin and metalloproteinase with thrombospondin motifs) are MMP (matrix metalloproteinase) -related enzymes ... [more ▼]

Introduction: ADAMs (a disintegrin and metalloproteinase) and ADAMTS proteinases (a disintegrin and metalloproteinase with thrombospondin motifs) are MMP (matrix metalloproteinase) -related enzymes, bearing a multi-domain structure. ADAM28 is a multipotent membrane-bound proteinase and its expression in tissues derived from the foregut in embryonic tissues suggests its involvement in the organogenesis of the respiratory tract. Moreover, ADAM28 is highly overexpressed in non-small-cell lung cancer samples. Notably through a global proteomic approach, we recently identified an upregulation of ADAM28 after induction of lung inflammation in a mouse model of asthma. In addition to data published in the literature and to our findings about ADAM28 expression in various pathological tissues, intrinsic characteristics of this proteinase argue for considering it as a potential regulator of cellular signalling pathways leading to an inflammatory pulmonary microenvironment and, eventually, to carcinogenesis. Indeed, ADAM28 bears an active catalytic domain and interacts in a non-proteolytic manner with some integrins (α4β1) and some P-selectin ligands involved in inflammatory cell migration. ADAM28 was also reported to display the capacity to cleave key mediators such as Von Willebrand factor, IGFBP3 (Insulin-like growth factor-binding protein 3) and CTGF (Connective Tissue Growth Factor). Very recently, ADAM28 was shown to shed pro-TNF-alpha suggesting an important role in tumour control. The present project aims at characterizing molecular mechanisms leading to tumour development in lungs. In the first part of this work, we intend to characterize the effects of ADAM28 depletion on physiological and pathological processes such as tumor development and metastatic dissemination in ADAM28 conditional knock-out mice. Methods: To understand the implication of ADAM28 in lung tumour development we instillated lungs of mice displaying a full knock-out genotype for ADAM28 with Lewis Lung Carcinoma cells and B16K1 melanoma cells. ADAM28 KO mice were also injected intravenously and a subcutaneously with these tumour cells. Results: There is no spontaneous phenotype for ADAM28 full knock-out animals. Preliminary results show an impaired lung tumors engrafment in ADAM28 wild type animals when compared to heterozygous or knock out littermates. Conclusion: This unique mouse strain provides a very precious tool to further investigate ADAM28 implication in various disease models including tumour growth and dissemination. The role of ADAM28 as a pro-tumor factor is widely described in the literature whereas our results suggest that ADAM28 has an anti-tumor function. [less ▲]

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See detailTempus fugit
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2016), 59

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See detailL’évaluation de la formation : comment la rendre utile pour les participants ? Constats et proposition de cinq stratégies d’évaluation partenariale
Faulx, Daniel ULg; Danse, Cédric ULg

in Evaluer : Journal International de Recherche en Education et Formation (2016), 2(1), 37-52

L’évaluation de la formation par les participants est une pratique courante aujourd’hui, portée à la fois par des exigences de rentabilité et de qualité. Cependant, cet exercice, qui se présente ... [more ▼]

L’évaluation de la formation par les participants est une pratique courante aujourd’hui, portée à la fois par des exigences de rentabilité et de qualité. Cependant, cet exercice, qui se présente souvent sous la forme de questionnaires individuels remis à la fin de la formation, peut être vécu par ceux qui les remplissent comme un rituel obligé mais présentant peu d’intérêt. C’est dans l’intention de proposer une alternative à cette situation que cet article a été rédigé. Dans un premier temps, nous faisons le point sur les modes les plus habituels d’évaluation de la formation par les participants. Nous identifions les récurrences de ce genre de pratique et les questions qu’elles posent. Ensuite, nous avançons cinq manières de procéder à une évaluation de telle sorte qu’elle soit bénéfique tant aux apprenants qu’au formateur. Les propositions sont réparties en deux familles (centrée sur l’activité de l’apprenant et centrée sur le processus de formation). Elles visent, au contraire de ce qui est pratiqué habituellement, à mettre au travail chacun des acteurs, formateur comme apprenants, afin que le moment de l’évaluation constitue une occasion de continuer à apprendre. Cette approche est aussi potentiellement transférable en contexte scolaire lors de l’évaluation des enseignants (ou des enseignements) par les élèves/étudiants. [less ▲]

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See detailLes soins en hôpital de jour : du trou de serrure au jeu de clés…
REUTER, Benjamin ULg; TIBERGHIEN, Céline; Triffaux, Jean-Marc ULg

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2016), 18

During a new period of disruption with the hospital-tradition of psychiatric care, the specificity and originality of the Day Hospital remains to be defined. The metaphoric dimension of the therapeutic ... [more ▼]

During a new period of disruption with the hospital-tradition of psychiatric care, the specificity and originality of the Day Hospital remains to be defined. The metaphoric dimension of the therapeutic “passe-partout”, could be appliqued to hospitals which are to this day, part of institutional therapy story: The care teams have effectively replaced the walls to accommodate the most complex mental diseases. Several therapeutic “keys” are well produced and co-constructed with the fundamental goal of allowing the patient to (re) gain freedom-bridges lost under the weight of his psychopathology. Even though in 40 years the Day Hospital continues to evolve and reinvent, it interestingly gets through crises. This ability to overcome crises is seen in the deinstitutionalization crisis where it was handled with stability due to its originality. Stability does not mean stagnation: the daily questioning of the therapeutic work group leads us… Thanks to this article, we will specifically highlight the therapeutic effect observed across the different support models to the Day Hospital. [less ▲]

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See detailGuide du post-partum
Emonts, Patrick ULg

Book published by deboeck (2016)

Guide of the post-partum drafted for the attention of all the persons receiving benefits of care involved in the post-partum. Daily reference tool for all the professionals of French language. Guide du ... [more ▼]

Guide of the post-partum drafted for the attention of all the persons receiving benefits of care involved in the post-partum. Daily reference tool for all the professionals of French language. Guide du post-partum rédigé à l'attention de tous les prestataires de soins impliqués dans le post-partum. Outil de référence quotidien à l'usage de tous les professionnels de langue française. [less ▲]

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See detailIntroduction à AquaCrop: élaboration de calendriers d'irrigation
Wellens, Joost ULg

Scientific conference (2016, October)

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See detailStudy of the SV2A protein role in Epilepsy.
Bartholomé, Odile ULg; Van Den Ackerveken, Priscilla ULg; Wislet, Sabine ULg et al

Poster (2016, October)

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See detailUsing images to analyze images. Semiotics meets Cultural Analytics
Dondero, Maria Giulia ULg

in Reyes-Garcia, Everardo; Châtel-Innocenti, Pierre; Zreik, Khaldoun (Eds.) Archiving and Questioning Immateriality - Proceedings of the 5th Computer Art Congress (2016, October)

In our text we examine image visualizations generated from big collections of archived images produced by Lev Manovich and his team in the field of Cultural Analytics. Our aim is to examine how these ... [more ▼]

In our text we examine image visualizations generated from big collections of archived images produced by Lev Manovich and his team in the field of Cultural Analytics. Our aim is to examine how these image visualizations function as analysis-images from two correlated perspectives of one semiotic approach: 1. Enunciation. What point of view is conveyed by the image visualizations about the computer-manipulated archive images? 2. Rhetorical/mereological composition: What is the mereological relation between the final visualization and the multitude of images that it contains, filters, or manipulates? [less ▲]

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See detailDroit international pénal approfondi (2016-2017)
Deprez, Christophe ULg

Learning material (2016)

Ces documents pédagogiques ont servi de support à un cours de Droit international pénal approfondi, dispensé à l'Université de Lille 2 dans le cadre du M2 "Justice pénale internationale".

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See detailL'image peut-elle nier?
Dondero, Maria Giulia ULg; Badir, Sémir ULg

Book published by presses universitaires de Liège (2016)

L’image peut-elle nier ? La question est en apparence toute simple et attendrait une réponse catégorique, oui ou non. Si pourtant, dans le présent ouvrage, des linguistes, des sémioticiens, des ... [more ▼]

L’image peut-elle nier ? La question est en apparence toute simple et attendrait une réponse catégorique, oui ou non. Si pourtant, dans le présent ouvrage, des linguistes, des sémioticiens, des philosophes, des spécialistes des arts visuels et audiovisuels se sont penchés sur cette question, c’est qu’en réalité tout fait problème en elle. Car répondre à une telle question, cela consisterait d’abord à déterminer les conditions dans lesquelles elle se pose. Qu’appelle-t-on « nier » et qu’appelle-t-on « image » ? Et selon quel corpus d’images ? Peut-on donner une réponse unique à la diversité de ses domaines d’usage : les arts, les religions et les sciences, ainsi que de ses genres (portrait, nature morte, etc.) ? Les contributeurs du présent volume explorent différentes sortes de supports médiatiques et d’objets visuels : expériences picturales contemporaines, photographie, films, peinture chinoise, mais aussi peinture religieuse médiévale, pictographies esquimaudes de la fin du XIXe siècle ou hiéroglyphes égyptiens. Une première partie, intitulée « L’énonciation en image », explore les relations entre la négation dans l’image et la théorie de l’énonciation comme celle-ci est revisitée par la sémiotique contemporaine. Une seconde, ayant pour titre « Du langage verbal aux images », s’attache à des comparaisons entre les sens de la négation dans différentes langues et grammaires et leurs cultures visuelles respectives. Les comparaisons inévitables avec d’autres lieux d’exercice de la négation — à savoir les langages formels et les langues verbales — et l’examen des transferts conceptuels non moins indispensables que ces comparaisons suscitent mettent ainsi à l’épreuve d’une question le statut ontologique de l’image. [less ▲]

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See detailThe smallholder development by remittances of migrants
Yao Namé, Juste Michel ULg; Lebailly, Philippe ULg

in African Association of Agricultural Economists (AAAE)/AgEconsearch (2016, October)

The following pages report the results of our survey conducted among (Malian, Senegalese and Mauritanian) Soninké migrants during the period of 14th to 4 December 2015, living in the social residences of ... [more ▼]

The following pages report the results of our survey conducted among (Malian, Senegalese and Mauritanian) Soninké migrants during the period of 14th to 4 December 2015, living in the social residences of the former home Pinel (first home of migrant workers in France). This survey had to aim to discuss the implementation and use of a new tool to transfer the money in order to reduce use of informal channels, to promote financial inclusion, to finance smallholding and to develop entrepreneurship in rural by granting of credits medium or long term via Microfinance Institutions (IMF). [less ▲]

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See detailInternational Trade Sanctions related to Dual-Use Goods and Technologies
Colussi, Ilaria Anna ULg

in Athens Journal of Law (2016), 2(4), 237-252

One of the basic rules in trade law is the freedom of trade. However, such rule encounters some limitations when the object of trade is constituted by strategic items, such as dual-use items, which may ... [more ▼]

One of the basic rules in trade law is the freedom of trade. However, such rule encounters some limitations when the object of trade is constituted by strategic items, such as dual-use items, which may have peaceful (civilian/commercial) or non peaceful/military applications. Trade of these categories of goods needs to be controlled, as they can provoke security concerns. Such control is pursued through control lists, licenses, authorizations to stakeholders of the supply chain, information- sharing and cooperation mechanisms, reports, records, declarations, screenings and sanctions as well. The paper aims at focusing on the issue of sanctions, in particular the ones established at the international level: these measures are provided for the violation of trade rules in reference to dual-use items, and/or sanctions have as an object this type of goods. The legal provisions established by the World Trade Organization (WTO) and at the United Nations level are analysed thereafter. Brief observations are offered as regards the EU framework of restrictive measures too. [less ▲]

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See detailOceanBrowser: on-line visualization of gridded ocean data and in situ observations
Barth, Alexander ULg; Watelet, Sylvain ULg; Troupin, Charles et al

Conference (2016, October)

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See detailApparition de la puberté chez les agneaux mâles de race Ouled Djellal
Boussena, Sabrina; Bouaziz, O.; Hireche, S. et al

in Revue de Médecine Vétérinaire (2016), 167(9-10), 274-282

The aim of this study is to evaluate the body and testicular growth performances in Ouled Djellal rams from weaning until twelve months of age. It also contributes to the study of the onset of puberty in ... [more ▼]

The aim of this study is to evaluate the body and testicular growth performances in Ouled Djellal rams from weaning until twelve months of age. It also contributes to the study of the onset of puberty in Ouled Djellal rams and to follow the subsequent evolution of their semen production. Weekly measurements of body weight, chest perimeter, scrotal circumference, testicular length and diameter, as well as the cauda-epididymis diameter of the gonads were conducted in ten rams, from weaning and until the onset of puberty. Semen collection was also performed in the same manner with an electroejaculator in order to define puberty. After the onset of puberty, observations were made fortnightly on body weight, chest perimeter, testis morphometry and the evolution of semen characteristics. Puberty settled at an average age of 228± 7 days with an average weight of 40.4 ± 1.2 kg. Highly significant correlations were observed between testicular measurements and those of the body. Similar significant correlations were also observed between testicular measurements (especially scrotal circumference) and semen characteristics after puberty. [less ▲]

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See detailDon et dette de vie à l'adolescence
Haxhe, Stéphanie ULg; de Saint Georges, Marie-Christine; Michard, Pierre et al

in Adolescence (2016), 34(3), 597-605

L’adolescent récuse la dette de vie et réclame autonomie et considération. Néanmoins, la société actuelle offre à l’adolescent des parents fragilisés. La réalité de l’adolescent contemporain apparaît ... [more ▼]

L’adolescent récuse la dette de vie et réclame autonomie et considération. Néanmoins, la société actuelle offre à l’adolescent des parents fragilisés. La réalité de l’adolescent contemporain apparaît alors comme une quête en tension entre une nécessaire appropriation de lui-même et des dons discrets à ses parents. Si ces dons ne sont pas reçus et échouent à introduire parents et adolescent à une nouvelle position relationnelle, le risque d’un épuisement de l’adolescent est à prendre en considération. [less ▲]

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See detailComment élaborer des tarifs en assurance non vie
Esch, Louis ULg

Scientific conference (2016, October)

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See detailClassification Criteria for Neurogenic Claudication Caused by Lumbar Spinal Stenosis
Genevay, Stéphane; Courvoisier, Delphine; Konstantinou, Kika et al

in EuroSpine 2016 (2016, October)

BACKGROUND Classification criteria are recommended for diseases that lack highly specific biomarkers in order to improve homogeneity in clinical research. Since imaging evidence of lumbar spinal stenosis ... [more ▼]

BACKGROUND Classification criteria are recommended for diseases that lack highly specific biomarkers in order to improve homogeneity in clinical research. Since imaging evidence of lumbar spinal stenosis (LSS) or lumbar disc herniations (LDH) may not be associated with symptoms, clinical classification criteria based upon patient symptoms and physical examination findings are required. This study sought to develop a set of criteria identifying patients with neurogenic claudication (NC) caused by LSS and patient with radicular pain (RP) caused by LDH. This abstract reports the results concerning NC caused by LSS. METHODS Phase 1: Nineteen spine specialists (clinicians and researchers) from 8 countries participated in a Delphi process, using an internet program, to rank symptoms and signs which suggest LSS as the cause of NC or DH as the cause of RP. Phase 2: Nineteen different spine specialists (surgeons and non-surgeons) from 5 countries recruited patients during office visits and classify them with a high degree of confidence as having with either: 1) NC caused by LSS 2) RP caused by LDH or 3) non-specific low back pain (NSLBP) with non-specific leg pain radiation. Patients completed survey items and specialists documented examination signs. Signs and symptoms present in ≥ 10 patients were analyzed by using Generalized Estimating Equations (GEE). Patients with NC caused by LSS or NSLBP served as controls. Items with p<0.1 in univariate analysis were entered in the multivariate analysis. A score to predict NC caused by LSS was developed based on the coefficient of the GEE, and used to obtain a ROC curve and the associated area under the curve (AUC). RESULTS A list of 46 clinical signs and 28 patient-reported symptoms were selected by the group of spine specialists during the 1st phase. For the 2nd phase, 209 patients with high confidence in the diagnosis were included 63 NC caused by LSS, 89 RP caused by DH, and 57 NSLBP with non-specific leg pain radiation. Items which predicted NC with a p-value <0.1 included age >60, bilateral leg pain, leg pain relieved by sitting, leg pain decreased by leaning or flexing, positive30 seconds extension test, negative straight leg raise test. The score had an AUC of 0.91, and the cutoff to obtain a specificity of 92.1% resulted in a sensitivity of 80.0%. CONCLUSION An international collaboration of surgeon and non-surgeon spine specialists produced a set of diagnostic criteria with high specificity and sensitivity for identifying patients with NC caused by LSS. Using this set could improve the quality of basic science and clinical research in this field by improving homogeneity within groups of patients. [less ▲]

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See detailClassification criteria for neurogenic claudication caused by lumbar spinal stenosis
Genevay, Stéphane; Courvoisier, Delphine; Konstantinou, Kika et al

in 9th Interdisciplinary World Congress on Low Back And Pelvic Girdle Pain (2016, October)

BACKGROUND Classification criteria are recommended for diseases that lack highly specific biomarkers in order to improve homogeneity in clinical research. Since imaging evidence of lumbar spinal stenosis ... [more ▼]

BACKGROUND Classification criteria are recommended for diseases that lack highly specific biomarkers in order to improve homogeneity in clinical research. Since imaging evidence of lumbar spinal stenosis (LSS) or lumbar disc herniations (LDH) may not be associated with symptoms, clinical classification criteria based upon patient symptoms and physical examination findings are required. This study sought to develop a set of criteria identifying patients with neurogenic claudication (NC) caused by LSS and patient with radicular pain (RP) caused by LDH. This abstract reports the results concerning NC caused by LSS. METHODS Phase 1: Nineteen spine specialists (clinicians and researchers) from 8 countries participated in a Delphi process, using an internet program, to rank symptoms and signs which suggest LSS as the cause of NC or DH as the cause of RP. Phase 2: Nineteen different spine specialists (surgeons and non-surgeons) from 5 countries recruited patients during office visits and classify them with a high degree of confidence as having with either: 1) NC caused by LSS 2) RP caused by LDH or 3) non-specific low back pain (NSLBP) with non-specific leg pain radiation. Patients completed survey items and specialists documented examination signs. Signs and symptoms present in ≥ 10 patients were analyzed by using Generalized Estimating Equations (GEE). Patients with NC caused by LSS or NSLBP served as controls. Items with p<0.1 in univariate analysis were entered in the multivariate analysis. A score to predict NC caused by LSS was developed based on the coefficient of the GEE, and used to obtain a ROC curve and the associated area under the curve (AUC). RESULTS A list of 46 clinical signs and 28 patient-reported symptoms were selected by the group of spine specialists during the 1st phase. For the 2nd phase, 209 patients with high confidence in the diagnosis were included 63 NC caused by LSS, 89 RP caused by DH, and 57 NSLBP with non-specific leg pain radiation. Items which predicted NC with a p-value <0.1 included age >60, bilateral leg pain, leg pain relieved by sitting, leg pain decreased by leaning or flexing, positive30 seconds extension test, negative straight leg raise test. The score had an AUC of 0.91, and the cutoff to obtain a specificity of 92.1% resulted in a sensitivity of 80.0%. CONCLUSION An international collaboration of surgeon and non-surgeon spine specialists produced a set of diagnostic criteria with high specificity and sensitivity for identifying patients with NC caused by LSS. Using this set could improve the quality of basic science and clinical research in this field by improving homogeneity within groups of patients. [less ▲]

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