Last 7 days
Bookmark and Share    
See detailZinc, manganese and iron interaction within the frd3 Arabidopsis mutant
Scheepers, Maxime ULg; Spielmann, Julien ULg; Goormaghtigh, Erik et al

Poster (2017, February 01)

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailUsing unsupervised clustering method and SNP-based information to identify fine-level population structure
Chaichoompu, Kridsadakorn ULg; Yazew, Fentaw Abegaz; Tongsima, Sissades et al

Poster (2017, February 01)

Detailed reference viewed: 23 (2 ULg)
Full Text
Peer Reviewed
See detailImproved Blood Glucose Forecasting Models using Changes in Insulin Sensitivity in Intensive Care Patients
Uyttendaele, Vincent ULg; Dickson, Jennifer; Shaw, Geoff et al

Poster (2017, February 01)

Introduction: Hyperglycaemia, hypoglycaemia and glycaemic variability are associated with worsened outcomes and increased mortality in intensive care units. Glycaemic control (GC) using insulin therapy ... [more ▼]

Introduction: Hyperglycaemia, hypoglycaemia and glycaemic variability are associated with worsened outcomes and increased mortality in intensive care units. Glycaemic control (GC) using insulin therapy has shown improved outcomes, but have been proven difficult to repeat or achieve safely. STAR (Stochastic TARgeted) is a model-based glycaemic control protocol using a stochastic model to forecast distributions of likely future changes in insulin sensitivity (SI) based on its current value. This can be used to determine likely future blood glucose (BG) levels for a given intervention, enabling the most optimal dose selection that best overlaps a clinically defined BG target band. This study presents a novel 3D model capable to predict likely future distribution of SI using both current SI and its prior variability (%ΔSI). Methods: Metabolic data from 3 clinical ICU cohorts totalling 819 episodes and 68629 hours of treatment under STAR and SPRINT protocols are used in this study. Data triplets (%ΔSIn, SIn, SIn+1) are created and binned together in a range of %ΔSI = [-100%, 200%] and SIn = [1.0e-7, 2.1e-3] in bin sizes of %ΔSI = 10% and SIn = 0.5e-4. The 5th, 50th, and 95th percentile of SIn+1 are determined for each bin where data density is high enough (>100 triplets) and compared to the previous stochastic model. The predictive power of the two models are compared by computing median [IQR] per-patient percentage prediction of SI within the 5th-95th and 25th-75th percentile ranges of model predictions. Results: Results show the previous model is over-conservative for ~77% of the data, mainly where %ΔSI is within an absolute 25% change. The percentage change in the 90% CI width in this region is reduced by ~25-40%. Conversely, non-conservative regions are also identified, with 90% CI width increased up to ~80%. Predictive power is similar for both model (60.3% [47.8%, 71.5%] vs. 51.2 [42.9%, 59.2%] within 25th-75th and 93.6% [85.7%, 97.3%] vs. 90.7% [84.4%, 94.6%] within 5th-95th range). Conclusions: The new 3D model achieved similar predictive power as the previous model by reducing the 5th-95th percentile prediction range for 77% of the data, predominantly where SI is stable. If the conservatism of the previous model reduces risk of hypoglycaemia, it also inhibits the controller’s ability to reduce BG to the normal range by safely using more aggressive dosing. The 3D new model thus better characterises patient-specific response to insulin, and allows more optimal dosing, increasing performance and safety. [less ▲]

Detailed reference viewed: 20 (2 ULg)
Full Text
See detailMicroalgues: du laboratoire au pilote industriel pour la production de molécules bioactives
Franck, Fabrice ULg; Gerards, Thomas ULg

Scientific conference (2017, February 01)

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailStrong XUV irradiation of the Earth-sized exoplanets orbiting the ultracool dwarf TRAPPIST-1
Wheatley, Peter J.; Louden, Tom; Bourrier, Vincent et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

We present an XMM-Newton X-ray observation of TRAPPIST-1, which is an ultracool dwarf star recently discovered to host three transiting and temperate Earth-sized planets. We find the star is a relatively ... [more ▼]

We present an XMM-Newton X-ray observation of TRAPPIST-1, which is an ultracool dwarf star recently discovered to host three transiting and temperate Earth-sized planets. We find the star is a relatively strong and variable coronal X-ray source with an X-ray luminosity similar to that of the quiet Sun, despite its much lower bolometric luminosity. We find L_x/L_bol=2-4x10^-4, with the total XUV emission in the range L_xuv/L_bol=6-9x10^-4. Using a simple energy-limited model we show that the relatively close-in Earth-sized planets, which span the classical habitable zone of the star, are subject to sufficient X-ray and EUV irradiation to significantly alter their primary and perhaps secondary atmospheres. Understanding whether this high-energy irradiation makes the planets more or less habitable is a complex question, but our measured fluxes will be an important input to the necessary models of atmospheric evolution. [less ▲]

Detailed reference viewed: 61 (1 ULg)
Full Text
See detailModelling BMP-2 carrier device for bone tissue engineering application
Manhas, Varun ULg; Carlier, Aurelie; Geris, Liesbet ULg

Poster (2017, February 01)

Detailed reference viewed: 25 (3 ULg)
See detailCellular stress and β-lactamase BlaP induction in Bacillus licheniformis
Dauvin, Marjorie ULg; Joris, Bernard ULg

Poster (2017, February 01)

In presence of β-lactam antibiotic in its environment, B. licheniformis produces the β-lactamase BlaP, an enzyme hydrolyzing β-lactam antibiotic, conferring on the bacteria phenotypic resistance. To ... [more ▼]

In presence of β-lactam antibiotic in its environment, B. licheniformis produces the β-lactamase BlaP, an enzyme hydrolyzing β-lactam antibiotic, conferring on the bacteria phenotypic resistance. To induce BlaP, two conditions must be fulfilled. The first one is the acylation of the membrane receptor BlaR1 by the antibiotic. The second one is a cellular stress due to the presence of the antibiotic which acylate PBP1. The nature of this signal remains unknown. In this study we postulate that the extracytoplasmic function sigma factors (ECFs) σM and σX act together with the stringent response as a secondary and redundant layer of stress upon which the BlaP induction pathway relies. [less ▲]

Detailed reference viewed: 7 (1 ULg)
Full Text
See detailXMM-Newton : en route vers une autre décennie de découvertes
Rauw, Grégor ULg

Article for general public (2017)

Au mois de décembre 2016, cela faisait 17 ans que XMM-Newton fut lancé par une fusée Ariane V. Equipé de ses trois modules miroirs comportant chacun 58 miroirs imbriqués les uns dans les autres, XMM ... [more ▼]

Au mois de décembre 2016, cela faisait 17 ans que XMM-Newton fut lancé par une fusée Ariane V. Equipé de ses trois modules miroirs comportant chacun 58 miroirs imbriqués les uns dans les autres, XMM-Newton est à l’affût de l’émission X de sources cosmiques de tout genre. Malgré sa longévité, XMM-Newton reste à ce jour un des observatoires les plus sollicités au monde. Chaque année, les astrophysiciens proposent des programmes d’observation qui totalisent à peu près 6 fois le temps d’observation disponible! La compétition pour les observations avec XMM est donc très rude. Et a priori cela pourrait continuer encore comme cela pendant quelques années. De fait, les réserves de carburant et la performance des panneaux solaires indiquent que la mission pourrait encore fonctionner au moins 10 ans si les budgets le permettent1! [less ▲]

Detailed reference viewed: 22 (0 ULg)
Full Text
Peer Reviewed
See detailGlomerular filtration rate in healthy living potential kidney donors: a meta-analysis supporting the construction of the the Full Age Spectrum equation.
Pottel, H; Hoste, L; Yayo, E et al

in Nephron (2017), 135(2), 105-119

Detailed reference viewed: 26 (1 ULg)
See detailAttack-Prevention and Damage-Control Investments in Cybersecurity
Lam, Wing Man Wynne ULg

Scientific conference (2017, February)

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailLa réforme de l'aide juridique : suivez le guide !
Michiels, Olivier ULg; Falque, Géraldine ULg

in Les droits du justiciable face à la justice pénale (2017)

Detailed reference viewed: 22 (2 ULg)
Full Text
Peer Reviewed
See detailIntention, image et singularité selon le premier Sartre : réflexion sur les propriétés et les fonctions de l'acte d'imagination
Recchia, Fabio ULg

in Bulletin d'Analyse Phénoménologique (2017, February)

Partant d’une problématisation de la méthode phénoménologique mise en jeu par "L’Imaginaire", nous proposons de relire les développements de ce texte à partir de la perspective offerte par la théorie de ... [more ▼]

Partant d’une problématisation de la méthode phénoménologique mise en jeu par "L’Imaginaire", nous proposons de relire les développements de ce texte à partir de la perspective offerte par la théorie de l’intentionnalité du premier Sartre. Nous tenterons ainsi de dégager l’unité systématique du projet sartrien d’une « phénoménologie de l’image » en le rapportant aux propositions philosophiques posées de manière décisive par "l’article sur l’intentionnalité". Par ce biais, il s’agira également de fixer les propriétés de la conscience imageante, ainsi que les fonctions jouées par l’acte d’imagination dans l’économie générale de la conscience, en particulier dans l’événement de sa personnalisation. De sorte que nous parcourons les tensions reliant l’imagination de la conscience à son ipséité ; tandis que, du point de vue de l’histoire de la philosophie, nous examinerons certaines des torsions qu’appliqua Sartre sur l’analyse husserlienne de l’image afin d’approfondir celle-ci dans la direction d’une philosophie de la liberté personnelle du sujet. [less ▲]

Detailed reference viewed: 21 (4 ULg)
Full Text
Peer Reviewed
See detailClinical settings in knee osteoarthritis: Pathophysiology guides treatment
Herrero-Beaumont, Gabriel; Roman-Blas, Jorge A; Bruyère, Olivier ULg et al

in Maturitas (2017), 96

Osteoarthritis (OA) is the most common chronic joint disorder and its prevalence increases rapidly during midlife. Complex interactions of genetic alterations, sex hormone deficit, and aging with ... [more ▼]

Osteoarthritis (OA) is the most common chronic joint disorder and its prevalence increases rapidly during midlife. Complex interactions of genetic alterations, sex hormone deficit, and aging with mechanical factors and systemic inflammation-associated metabolic syndrome lead to joint damage. Thus, the expression of a clinical phenotype in the early stages of OA relies on the main underlying pathway and predominant joint tissue involved at a given time. Moreover, OA often coexists with other morbidities in the same patient, which in turn condition the OA process. In this scenario, an appropriate identification of clinical phenotypes, especially in the early stages of the disease, may optimize the design of individualized treatments in OA. An ESCEO-EUGMS (European Union Geriatric Medicine Society) working group has recently suggested possible patient profiles in OA. Hereby, we propose the existence of 4 clinical phenotypes – biomechanical, osteoporotic, metabolic and inflammatory – whose characterization would help to properly stratify patients with OA in clinical trials or studies. Further research in this field is warranted. [less ▲]

Detailed reference viewed: 31 (5 ULg)