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 Last 7 days     Results 121-140 of 29613.   2 3 4 5 6 7 8 9 10 11 12   Thinking out of the box - New approaches to controlling GVHDBaron, Frédéric ; Humblet-Baron, Stéphanie; Ehx, Grégory et alin Current Hematologic Malignancy Reports (in press)Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD ... [more ▼]Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD prophylaxis regimens continue to bebased on the combination of a calcineurin inhibitor with an antimetabolite, while first line treatmentsstill relies on high-dose corticosteroids. Further, no second line treatment has emerged thus far in acute or chronic GVHD patients who failed on corticosteroids. After briefly reviewing current standards of GVHD prevention and treatment, this article will discuss recent approaches that might change GVHD prophylaxis / treatment in the next decades, with a special focus on recently developed immunoregulatory strategies based on infusion of mesenchymal stromal or regulatory T-cells, or on injection of lowdose interleukin-2. [less ▲]Detailed reference viewed: 14 (3 ULg) Control of electronic dynamics visualized by angularly resolved photoelectron spectra: An IR pump-XUV attopulse train probe dynamical simulationMignolet, Benoît ; Levine, R. D.; Remacle, Françoise in Physical Review A (rapid comm.) (in press)Detailed reference viewed: 12 (2 ULg) Boucle et répétition : musique, littérature, arts visuelsBelloi, Livio ; Delville, Michel ; Levaux, Christophe et alBook published by Presses Universitaires de Liège (in press)Detailed reference viewed: 26 (5 ULg) Classification of positron emission tomography images using multiple kernel learningSegovia-Román, Fermín ; Bastin, Christine ; Salmon, Eric et alin Proceeding of 3rd NIPS 2013 Workshop on Machine Learning and Interpretation in NeuroImaging (in press)Over the last years, several approaches to analyze nuclear medicine imaging using computer systems have been proposed with the aim of assisting the diagnosis of neurodegenerative disorders. Probably one ... [more ▼]Over the last years, several approaches to analyze nuclear medicine imaging using computer systems have been proposed with the aim of assisting the diagnosis of neurodegenerative disorders. Probably one of the most complex challenges facing these approaches is to deal with the huge amount of data provided by brain images. In this work, we propose an original approach based on multiple kernel learning. First the images were parcellated (according to the structure of the brain) by means of the automatic anatomical labeling atlas. Then, the importance of each region for the assisted diagnosis was estimated using a classifi- cation procedure. Finally, all the regions were combined in a multiple kernel method in which one kernel per region was computed and all the kernels were weighted according to the importance of the region they represented. For testing purposes, a database with 46 PET images from stable mild cognitive impairment subjects and early Alzheimer’s disease converter patients was used. An accuracy rate of 73.91% was achieved when differentiating between both groups. [less ▲]Detailed reference viewed: 10 (3 ULg) Les bases de données latines du LASLA : un banc d’essai pour tester les théories linguistiques ?Longrée, Dominique in Della villa, Jesus; Pompei, Anna (Eds.) Proceedings of the International Conference on Linguistics and Classical Languages (LCL), February 17-19, 2011 (in press)Detailed reference viewed: 12 (0 ULg) Vecchi e nuovi strumenti per esplorare le banche dati latine del LASLALongrée, Dominique in Lana, Maurizio (Ed.) Proceedings Tecnologie moderne per le opere degli antichi, Vercelli, 8 novembre 2011 (in press)Detailed reference viewed: 14 (3 ULg) Scale-down effect on the extracellular proteome of Escherichia coli: correlation with membrane permeability and modulation according substrate heterogeneitiesBrognaux, Alison ; Francis, Frédéric ; Twizere, Jean-Claude et alin Bioprocess and Biosystems Engineering (in press)Protein leakage is induced in well-mixed fed-batch bioreactor by comparison with cultures carried out in scale-down conditions. This effect is attributed to a progressive increase of cell membrane ... [more ▼]Protein leakage is induced in well-mixed fed-batch bioreactor by comparison with cultures carried out in scale-down conditions. This effect is attributed to a progressive increase of cell membrane permeability and the synthesis of several outer-membrane components allowing to cope with substrate limitation commonly found in high-cell density culture. A comparative analysis of protein leakage has thus been performed in well-mixed bioreactors and in scale-down devices. The extracellular proteome of E.coli has been investigated by 2D-gel electrophoresis and identified by subsequent MALDI-TOF analysis. On 110 picked spots, 67 proteins have been identified and the sub-localisation and the molecular function of these proteins have been determined. A majority of the extracellular proteome was composed of outer-membrane and periplasmic proteins (64%) confirming the fact that leakage is involved in high-cell density cultures. About 50% of this extracellular proteome was composed of transport and binding proteins. Furthermore, the more abundant spots on the gel corresponded to porin proteins and periplasmic transporters. In particular, the OmpC porin was found to be very abundant. Moreover, the scale-down effect on this extracellular proteome has been investigated by 2D-DIGE analysis (2-Dimensional Differential in-Gel Electrophoresis) and significant differences have been observed by comparison with culture carried out in well-mixed systems. Indeed, since substrate limitation signal is alleviated in this kind of apparatus, cell permeability was lowered as shown by flow cytometry. In scale-down conditions, protein leakage was thus less abundant. [less ▲]Detailed reference viewed: 24 (7 ULg) Apport de la musculation en sport collectifamateur : exemple du handball fémininJidovtseff, Boris ; Frère, Pauline; Theunissen, Catherine in Science & Sports (in press)Introduction. — The aim of the study was to verify, in a non-professional handball female, if theintroduction of two short workouts per week during all season has a positive impact on muscularperformance ... [more ▼]Introduction. — The aim of the study was to verify, in a non-professional handball female, if theintroduction of two short workouts per week during all season has a positive impact on muscularperformance.Methods. — Eighteen female playing handball at the top Belgian level were monitored duringthe complete season. Ten of these girls (‘‘Muscu’’ group) achieved, in addition to their usualtraining, two short (30 minutes) strength training sessions weekly. The other (‘‘Control’’ group)followed the usual training, without any strength training session. A battery of tests (leg power,arm power, vertical jump, sprint, throwing, flexibility) has been set up to four times during theseason to follow up muscular performance.Results. — According to the literature, the ‘‘Control’’ group showed any change in performanceduring the year. By contrast, ‘‘Muscu group results demonstrated that the short strength trai-ning program was efficient, with significant improvements in leg power (P < 0.005) and sprint(P < 0.05) tests. Increase in vertical jump was very close to the level of significance (P = 0.06).Arms power did not improve but appeared to be superior in the ‘‘Muscu’’ group in comparisonwith ‘‘Control’’ at the end of the season, which was not the case at the beginning.© 2013 Elsevier Masson SAS. All rights reserved. [less ▲]Detailed reference viewed: 237 (12 ULg) An astronomical survey conducted in BelgiumNazé, Yaël ; Fontaine, Sébastien in Physics Education (in press)This article presents the results of the first survey conducted in Belgium about the interest and knowledge in astronomy. Two samples were studied, the public at large (667 questionnaires) and students ... [more ▼]This article presents the results of the first survey conducted in Belgium about the interest and knowledge in astronomy. Two samples were studied, the public at large (667 questionnaires) and students (2589 questionnaires), but the results are generally similar in both samples. We evaluated people’s interest, main information source, and attitudes towards astronomy, as well as their supposed and actual knowledge of the subject. The main conclusion is that, despite a poor self-confidence, people do know the basic astronomical concepts. However, that knowledge is not deeply rooted, as reasoning questions show well-spread misconceptions and/or misunderstandings. [less ▲]Detailed reference viewed: 16 (6 ULg) His cognitis vs. His cognitis rebus : ordre des constituants et bornage de l’Ablatif absoluLongrée, Dominique ; Philippart de Foy, Caroline ; Purnelle, Gérald in Haverling, Gerd (Ed.) Proceedings of the 16th Int. Coll. on Latin Linguistics, Uppsala, 6-12 juin 2011 (in press)Detailed reference viewed: 9 (3 ULg) Étude anatomoradiologique d’un crâne déformé d’Ancón (Pérou)Ricciardetto, Antonio ; Boman, Françoise; Duchat, Florent et alin Charlier, Philippe (Ed.) Actes du Ve Colloque international de Pathographie (in press)Matériels et méthodes : l’étude porte sur un crâne déformé provenant d’Ancón au Pérou, inventorié au Muséum National d’Histoire Naturelle (MNHN) de Paris en 1889. L’étude est géographique, historique ... [more ▼]Matériels et méthodes : l’étude porte sur un crâne déformé provenant d’Ancón au Pérou, inventorié au Muséum National d’Histoire Naturelle (MNHN) de Paris en 1889. L’étude est géographique, historique, macroscopique et tomodensitométrique. Résultats : situé sur la côte à 40 km au nord de Lima, la capitale du Pérou, le site d’Ancón est un site archéologique de la période lithique, et un lieu de sépulture depuis l’époque Chavín (1250 à 250 av. J.-Chr.). Dès l’époque Chavín, les peuples du Pérou ancien construisaient des centres cérémoniels dirigés par une élite théocratique, et déformaient le crâne des enfants dès les premiers jours de la vie, à l’aide de moyens de pression variés. La déformation du crâne d’Ancón est une déformation antéro-postérieure oblique, brachycéphale, bilobée et asymétrique, sans trépanation ni déformation dentaire associée. C’est une variante bilobée du type Huaura de déformation crânienne, qui est associé aux régions de Chancay-Ancón et Lima. L’étude tomodensitométrique des variations d’épaisseur de la voûte, avec amincissement en regard des zones de pression, a montré que la déformation était intentionnelle, et caractérisée par une pression fronto-pariéto-temporale bilatérale surtout antérieure et dégressive d’avant en arrière, associée à une pression frontale, occipitale, et sagittale médiane. En l’absence de contexte et de datation, l’ancienneté du crâne étudié ne peut pas être précisée au long d’une période de presque trois millénaires, jusqu’à la domination Inca et l’arrivée des Espagnols (1532). Le crâne pourrait appartenir à l’une ou l’autre des cultures successives du site d’Ancón : Chavín, Baňos de Boza o Miramar, Lima, Wari, et Chancay (1200 à 1470), dont les céramiques représentent la déformation bilobée. Le crâne est probablement celui d’une femme âgée de plus de 45 ans à son décès, de statut social élevé, faisant partie de l’élite magico-religieuse, politique et économique dirigeante. L’étude de l’endocrâne a permis d’observer la déformation des veines superficielles et des lobes du cerveau. Il existe des signes de parodonpathie chronique à un stade avancé. Un abcès d’origine dentaire pourrait avoir été la cause du décès. Conclusions et perspectives : en ce qui concerne la pratique des déformations crâniennes, la région d’Ancón-Chancay et de Lima paraît être remarquable à trois égards : par le grand nombre de crânes déformés, par le grand nombre de crânes bilobés, et par la proportion importante de femmes, dont on peut supposer qu’elles étaient nées de familles nobles, et destinées dès l’enfance à faire partie de l’élite théocratique. La reconstitution 3D de l’épaisseur de la voûte crânienne a permis pour la première fois à notre connaissance de caractériser ce type de déformation, et pourrait permettre de reconstituer l’appareil déformateur. Seule la reprise des exhumations programmées sur le site d’Ancón, dans le cadre d’un projet prospectif pluridisciplinaire, pourrait permettre de mieux préciser la proportion d’individus à crâne déformé, la proportion des crânes bilobés, et le sex ratio, dans chaque contexte historique et socio-culturel de ce type de déformation crânienne intentionnelle ; et, peut-être, de retrouver in situ l’appareil déformateur correspondant. [less ▲]Detailed reference viewed: 10 (1 ULg) Synthèse bibliographique sur la mobilité des éléments traces dans les sols et l’utilisation de la stabilisation physico-chimique comme technique de gestion in situ des sites contaminésLiénard, Amandine ; Colinet, Gilles in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)Industrial activities have deeply impacted the quality of biophysical environment at places. This review focuses on consequences of soil contaminations by metallic trace elements: what conditions the ... [more ▼]Industrial activities have deeply impacted the quality of biophysical environment at places. This review focuses on consequences of soil contaminations by metallic trace elements: what conditions the mobility of contaminants in soils and what are the remediation practices based upon physico-chemical stabilization? This technique is an in situ remediation which aims at limiting the dispersion of metals in the environment by use of soil conditioners and amendments in contaminated sites. First of all, we reviewed the concepts of mobility of trace elements and their indicators. Then, we compiled the different kinds of amendments applied to stabilize contaminants in soils and the processes involved. [less ▲]Detailed reference viewed: 24 (4 ULg) ÉVOLUTION DE LA TENEUR EN EAU LE LONG D’UNE TOPOSEQUENCE FORESTIERE ARGILO-LIMONEUSEDeraedt, Deborah ; Colinet, Gilles ; Degré, Aurore in Milieux Poreux et Transferts Hydriques (in press)For the hydrological modeling of forested watersheds, the understanding of the forest hydrodynamic is essential. This study focusses on the hydrology of a Belgian forested plot with high stoniness and ... [more ▼]For the hydrological modeling of forested watersheds, the understanding of the forest hydrodynamic is essential. This study focusses on the hydrology of a Belgian forested plot with high stoniness and steep slope. The soil water content is monitored at several positions on the toposequence and at different depth. During rain events, peak in soil water content are observed in different depth depending on the position along the toposequence. [less ▲]Detailed reference viewed: 33 (9 ULg) Linguistique ancienneLongrée, Dominique in Kastberg Sjöblom, Margareta; Leblanc, Jean Marc; Viprey, Jean Marie (Eds.) Vocabulaire de statistique pour l’analyse des textes et des discours (in press)Detailed reference viewed: 25 (2 ULg) Helicopter regulation in 112 Emergency Medical Communication Center : time-distances from landing to the patientStipulante, Samuel ; MOENS, Didier ; Pirotte, Olivier et alin AIRMED (in press)Detailed reference viewed: 15 (4 ULg) Analytical strategies for the detection of counterfeit erectile dysfunction drugs.Sacre, Pierre-Yves ; Deconinck, Eric; De Beer, Jacquesin Wang, Perry; Wertheimer, Albert (Eds.) Counterfeit Medicines Volume II: Detection, Identification and Analysis (in press)Among all classes of drugs, the type 5 phosphodiesterase inhibitors (PDE5-i) (sildenafil, vardenafil and tadalafil) are the most counterfeited and copied in industrialized countries. This is why it is ... [more ▼]Among all classes of drugs, the type 5 phosphodiesterase inhibitors (PDE5-i) (sildenafil, vardenafil and tadalafil) are the most counterfeited and copied in industrialized countries. This is why it is very important for regulatory agencies to have a panel of analytical methods to analyse these drugs and to be able to detect counterfeit or substandard medicines. During this chapter, several analytical techniques will be described and discussed. Among spectroscopic techniques, Raman, NIR, FT-IR and chemical imaging techniques will be envisaged. Their ability to detect counterfeits and predict if a new sample is genuine or not will be presented. Other techniques such as XRay powder diffraction and NMR spectroscopies will be briefly presented. Chromatographic impurity fingerprints will be considered and described for the analysis of suspect samples of Cialis® and Viagra®. Once again, the possibility to predict the authenticity of a new sample by the mean of this technique is envisaged. Finally, a MS-compatible UHPLC-UV method for the analysis of the three authorised PDE5-i and some of their analogues will be shortly described. This technique has been validated using spiked placebo samples in a vegetal matrix representing a suspect sample with a complex matrix. As a conclusion, a generic strategy for the detection and quality evaluation of counterfeit drugs will be presented. [less ▲]Detailed reference viewed: 107 (8 ULg) IntroductionLevaux, Christophe in Belloi, Livio; Delville, Michel; Levaux, Christophe (Eds.) et al Boucle et répétition : musique, littérature, arts visuels (in press)Detailed reference viewed: 11 (0 ULg) On the asymptotic standard error of a class of robust estimators of ability in dichotomous item response modelsMagis, David in British Journal of Mathematical & Statistical Psychology (in press)In item response theory, the classical estimators of ability are highly sensitive to response disturbances and can return strongly biased estimates of the true underlying ability level. Robust methods ... [more ▼]In item response theory, the classical estimators of ability are highly sensitive to response disturbances and can return strongly biased estimates of the true underlying ability level. Robust methods were introduced to lessen the impact of such aberrant responses onto the estimation process. The computation of asymptotic (i.e., large sample) standard errors (ASE) for these robust estimators, however, has not been fully considered yet. This paper focuses on a broad class of robust ability estimators, defined by an appropriate selection of the weight function and the residual measure, for which the ASE is derived from the theory of estimating equations. The maximum likelihood (ML) and the robust estimators, together with their estimated ASE, are then compared through a simulation study. It is concluded that both the estimators and their ASE perform similarly in absence of response disturbances, while the robust estimator and its estimated ASE are less biased and outperform their ML counterparts in presence of response disturbances with large impact on the item response process. [less ▲]Detailed reference viewed: 16 (2 ULg) A Schur Complement Method for DAE Systems in Power System Dynamic SimulationsAristidou, Petros ; Fabozzi, Davide; Van Cutsem, Thierry in Lecture Notes in Computational Science and Engineering (in press)This paper proposes a Schur complement-based Domain Decomposition Method to accelerate the time-domain simulation of large, non-linear and stiff Differential and Algebraic Equation systems stemming from ... [more ▼]This paper proposes a Schur complement-based Domain Decomposition Method to accelerate the time-domain simulation of large, non-linear and stiff Differential and Algebraic Equation systems stemming from power system dynamic studies. The proposed algorithm employs a star-shaped decomposition scheme and exploits the locality and sparsity of the system. The simulation is accelerated by the use of quasi-Newton schemes and parallel programming techniques. The proposed algorithm is implemented using the shared-memory parallel programming model and tested on a large-scale, realistic power system model showing significant speedup. [less ▲]Detailed reference viewed: 96 (21 ULg) A Super-Jupiter orbiting a late-type star: A refined analysis of microlensing event OGLE-2012-BLG-0406Tsapras, Y.; Choi, J.-Y.; Street, R. A. et alin Astrophysical Journal (in press)We present a detailed analysis of survey and follow-up observations of microlensing event OGLE-2012-BLG-0406 based on data obtained from 10 different observatories. Intensive coverage of the lightcurve ... [more ▼]We present a detailed analysis of survey and follow-up observations of microlensing event OGLE-2012-BLG-0406 based on data obtained from 10 different observatories. Intensive coverage of the lightcurve, especially the perturbation part, allowed us to accurately measure the parallax effect and lens orbital motion. Combining our measurement of the lens parallax with the angular Einstein radius determined from finite-source effects, we estimate the physical parameters of the lens system. We find that the event was caused by a $2.73\pm 0.43\ M_{\rm J}$ planet orbiting a $0.44\pm 0.07\ M_{\odot}$ early M-type star. The distance to the lens is $4.97\pm 0.29$\ kpc and the projected separation between the host star and its planet at the time of the event is $3.45\pm 0.26$ AU. We find that the additional coverage provided by follow-up observations, especially during the planetary perturbation, leads to a more accurate determination of the physical parameters of the lens. [less ▲]Detailed reference viewed: 14 (3 ULg)