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See detailIsolation and Identification of Steroid and Flavonoid Glycosides from the Flowers of Allium gramineum
Mskhiladze, Lasha; Chincharadze, David; St-Gelais, Alexis et al

in International Journal of Pharmaceutical Sciences and Drug Research (2016), 8(4), 240-243

The isolation and identification of β-sitosterol 3-O-β-glucopyranoside, quercetin 3-O-β-glucopyranoside, isorhamnetin 3,4'-di-O-β-glucopyranosideand isorhamnetin 3,7-di-O-β-glucopyranosidefrom the flowers ... [more ▼]

The isolation and identification of β-sitosterol 3-O-β-glucopyranoside, quercetin 3-O-β-glucopyranoside, isorhamnetin 3,4'-di-O-β-glucopyranosideand isorhamnetin 3,7-di-O-β-glucopyranosidefrom the flowers of Allium gramineumthat growsin Georgia.The structures of isolated compounds havebeen determined by 1H and 13C nuclear magnetic resonance (NMR) Isolation and Identification of Steroid and Flavonoid Glycosides from the Flowers of Allium gramineum. Available from: https://www.researchgate.net/publication/305851744_Isolation_and_Identification_of_Steroid_and_Flavonoid_Glycosides_from_the_Flowers_of_Allium_gramineum [accessed Aug 5, 2016]. [less ▲]

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See detailLe sexe ratio chez les bovins : facteurs de variation
Hanzen, Christian ULg; Chastant-Maillard, Sylvie; Rao, Anne-Sophie ULg et al

in Point Vétérinaire (Le) : Expert Rural (2016), 367

Le sexe ratio secondaire, défini comme la proportion de mâles à la naissance, est de 52% chez les bovins, avec des variations selon les populations étudiées de 46 à 57%. Il est plus élevé lors des ... [more ▼]

Le sexe ratio secondaire, défini comme la proportion de mâles à la naissance, est de 52% chez les bovins, avec des variations selon les populations étudiées de 46 à 57%. Il est plus élevé lors des premières étapes du développement embryonnaire, et les conceptus mâles meurent proportionnellement plus au cours de la gestation que les conceptus femelles. Les facteurs de variation potentiels sont nombreux, mais peu d’effets sont unanimement observés. L’effet de la parité ou du statut social de la vache ne sont pas clairement démontrés. Les ovulations sur l’ovaire droit donneraient naissance à une plus forte proportion de mâles ; le rôle du taureau est probablement limité et la répétabilité du sexe du veau d’une gestation à l’autre est faible. Le moment de l’insémination par rapport à l’ovulation ne semble pas avoir d’influence alors qu’il aurait pu constituer un moyen de maîtrise assez simple à mettre en œuvre. [less ▲]

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See detailIn search for a definition of sanctions in the context of strategic trade control
Colussi, Ilaria Anna ULg

in Paile, Sylvain; Michel, Quentin; Jankowitsch-Prevor, Odette (Eds.) Controlling the trade of strategic goods SANCTIONS AND PENALTIES (2016)

One of the basic rules in trade law is the freedom of trade. However, such rule encounters some limitations, derogations and exceptions when the object of trade is constituted by strategic and sensitive ... [more ▼]

One of the basic rules in trade law is the freedom of trade. However, such rule encounters some limitations, derogations and exceptions when the object of trade is constituted by strategic and sensitive items. The concept of “strategic trade” is one of the most ambiguous ones, and there is not a common definition of it. Even if the General Agreements on Tariffs and Trade (GATT) does not offer such an explanation, its Article XXI can be construed as referring to strategic trade, as much as it states that the provisions of GATT (grounded on free trade) need not apply in cases where “essential security interests” are involved. The concept of “essential security interests” is also vague, as it is left upon the individual parties to the GATT to decide what it means. Despite such ‘slippery slope’ in the definition of terms, it results, however, that strategic trade is linked to norms and measures that aim at controlling trade, in order to ensure the protection of non economic needs, such as national security, public morals, public order, etc. This area finds at the intersection of commercial and foreign policy. For ensuring the protection of non economic interests, it is necessary to introduce measures that provide for controls on all activities conducted by individuals, organizations, and groups regarding goods, equipment, materials, services related to strategic items: these activities shall cover the whole supply chain, including design, development, production, possession, delivery, transport, transit, trans-shipment, financing, brokering, exports, re-exports, transfers and imports. The actors intervening in the draft of rules and controls are mainly the States, and the international and regional organiza- tions; then, important subjects are national licencing authorities and enforcement agencies such as customs, border security, police and armed forces, if needed. The targets of such measures of control could be the States, if the rules at the international or regional level are addressing them, and/or the operators involved in strategic trade. Considering the ways in which States organize such controls, the reality shows that they have introduced control lists, licences and authorisations granted on the basis of conditions and criteria, information-sharing and cooperation between authorities and operators, duties of transparency through reports, records, dec- larations and screenings. Moreover, measures exist that consist of restrictions, bans and penalties providing that consequences in case of violation of strategic trade rules. Therefore, the issue of sanctions is a relevant part of the strategic trade law, and it inserts within that context. The purpose of this contribution is to define what sanctions in strategic trade mean and to systematize them accordingly. In particular, the sanctions are categorized into three groups: A. “supranational sanctions”; B. “implementing sanctions”; C. tertium genus: “unilateral sanctions” and “countermeasures”. [less ▲]

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See detailInventaire et typologie des listes grecques et latines de produits pharmaceutiques
Ricciardetto, Antonio ULg

in Derda, Tomasz; Lajtar, Adam; Urbanik, Jakub (Eds.) Proceedings of the XXVIIth International Congress of Papyrology. Warsaw, 29 July - 3 August 2013 (2016, July)

Dans la documentation papyrologique relative aux pratiques médicales de l’Égypte gréco-romaine et byzantine, le genre des listes de produits pharmaceutiques n’a encore jamais fait l’objet, ni d’un ... [more ▼]

Dans la documentation papyrologique relative aux pratiques médicales de l’Égypte gréco-romaine et byzantine, le genre des listes de produits pharmaceutiques n’a encore jamais fait l’objet, ni d’un inventaire, ni d’une étude exhaustifs. Dans le cadre de nos recherches doctorales sur la typologie des papyrus documentaires grecs et latins à caractère médical, c’est cette lacune que l’on se propose de combler, d’une part en cataloguant, au moyen de la fiche Mertens-Pack³ du CEDOPAL, la trentaine de listes de produits pharmaceutiques provenant d’Égypte, écrites en grec sur papyrus et ostracon (IIIe s. av. J.-Chr.-VIIe s. apr. J.-Chr.), auxquelles on ajoutera deux listes latines sur tablettes de bois, provenant du camp romain de Vindolanda (c. 100p), et, d’autre part, en analysant les aspects formels, paléographiques, textuels et contextuels de ces documents médicaux qui peuvent correspondre, soit à un inventaire de droguiste, soit à une commande, soit à une ou plusieurs recettes dont l’état fragmentaire du support a fait disparaître les proportions. On comparera les données obtenues avec d’autres pièces papyrologiques, spécialement les nombreuses prescriptions médicales, ainsi que les comptes, les reçus de paiement ou encore les lettres privées relatives à des demandes de médicaments ou à la livraison de substances pharmaceutiques. [less ▲]

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See detailCOST Action FA1407: Empowering NGS technologie for study and diagnostic of plant viruses
Massart, Sébastien ULg; Petter, François

Conference (2016, July)

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See detailCaractérisation phénotypique, morphologique et fonctionnelle des éosinophiles résidents du poumon
Raulier, Stéfanie ULg

Doctoral thesis (2016)

Eosinophils have long been considered as destructive effector cells implicated in parasitic infections and allergic reactions such as asthma. This traditional restrictive view of eosinophils has now been ... [more ▼]

Eosinophils have long been considered as destructive effector cells implicated in parasitic infections and allergic reactions such as asthma. This traditional restrictive view of eosinophils has now been considerably extended. Indeed, beside their pro-inflammatory functions, eosinophils are also able to finely shape local innate and adaptative immune responses. Moreover, recent studies indicate that steady-state resident eosinophils are now thought to contribute to immune homeostasis at mucosal sites such as the gut. In the normal lung, resident eosinophils (rEOS) have been little-studied so far. Here, we report that in mice, steady-state pulmonary rEOS are parenchymal Siglec-Fint CD125int cells characterized by a ring-shaped nucleus. [less ▲]

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See detailSafety of Everolimus Plus Exemestane In Patients With Hormone-Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer Progressing on Prior Non-Steroidal Aromatase Inhibitors: Primary Results of a Phase 3b, Open-Label, Single-Arm, Expanded-Access Multicenter Trial (BALLET).
Jerusalem, Guy ULg; Mariani, G.; Ciruelos, E. M. et al

in Annals of oncology : official journal of the European Society for Medical Oncology / ESMO (2016)

BACKGROUND: This European phase 3b, expanded-access multicenter trial evaluated the safety of EVE plus EXE in a patient population similar to BOLERO-2. PATIENTS AND METHODS: Postmenopausal women aged (3 ... [more ▼]

BACKGROUND: This European phase 3b, expanded-access multicenter trial evaluated the safety of EVE plus EXE in a patient population similar to BOLERO-2. PATIENTS AND METHODS: Postmenopausal women aged (3)18 years with hormone receptor-positive, human epidermal growth factor-receptor-2-negative advanced breast cancer (ABC) recurring/progressing during/after prior non-steroidal aromatase inhibitors (NSAIs) were enrolled. Primary objective was safety of EVE plus EXE based on frequency of adverse events (AEs), and serious AEs (SAEs). Secondary objective was to evaluate AEs of grade 3/4 severity. RESULTS: Median treatment duration was 5.1 months (95% CI, 4.8-5.6) for EVE and 5.3 months (95% CI, 4.8-5.6) for EXE. Overall, 2131 patients were included in the analysis; 81.8% of patients experienced EVE- or EXE-related or EVE/EXE-related AEs (investigator assessed); 27.2% were of grade 3/4 severity. The most frequently reported non-hematologic AEs were (overall %, % EVE-related) stomatitis (52.8%; 50.8%) and asthenia (22.8%; 14.6%). The most frequently reported hematologic AE were (overall %, % EVE-related) anemia (14.4%; 8.1%) and thrombocytopenia (5.9%; 4.6%). AE-related treatment discontinuations were higher in elderly ((3)70 years) versus non-elderly patients (23.8% vs. 13.0%). The incidence of EVE-related AEs in both elderly and non-elderly patients appeared to be lower in first-line ABC versus later lines. The incidence of AEs (including stomatitis/pneumonitis) was independent of BMI status (post-hoc analysis). Overall, 8.5% of patients experienced at least one EVE-related SAE. Of the 121 on-treatment deaths (5.7%), 66 (3.1%) deaths were due to disease progression and 46 (2.2%) due to AEs; 4 deaths were suspected to be EVE-related. CONCLUSIONS: This is the largest ever reported safety dataset on a general patient population presenting ABC treated with EVE plus EXE and included a sizeable elderly subset. Although the patients were more heavily pretreated, the safety profile of EVE plus EXE in BALLET was consistent with BOLERO-2. CLINICAL TRIAL REGISTRATION: EudraCT Number: 2012-000073-23. [less ▲]

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See detailEulerian Formulation of Elastic Rods
Huynen, Alexandre ULg; Detournay, Emmanuel; Denoël, Vincent ULg

in Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (2016), 472(2190),

In numerous biological, medical and engineering applications, elastic rods are constrained to deform inside or around tube-like surfaces. To solve efficiently this class of problems, the equations ... [more ▼]

In numerous biological, medical and engineering applications, elastic rods are constrained to deform inside or around tube-like surfaces. To solve efficiently this class of problems, the equations governing the deflection of elastic rods are reformulated within the Eulerian framework of this generic tubular constraint defined as a perfectly stiff canal surface. This reformulation hinges on describing the rod deformed configuration by means of its relative position with respect to a reference curve, defined as the axis or spine curve of the constraint, and on restating the rod local equilibrium in terms of the curvilinear coordinate parameterizing this curve. Associated with a segmentation strategy, which partitions the global problem into a sequence of rod segments either in continuous contact with the constraint or free of contact (except for their extremities), this approach not only trivializes the detection of new contacts but also suppresses the isoperimetric constraints resulting from the self-feeding feature of these elementary problems and the imposition of the rod position at the extremities of each rod segments. [less ▲]

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See detailAudition au Sénat sur une proposition de loi spéciale visant à modifier la loi spéciale sur la Cour constitutionnelle (proposition Doc. parl. 6-273/1)
Behrendt, Christian ULg

Report (2016)

Audition publique en Commission des affaires institutionnelles du Sénat, 3 juin 2016

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See detailConception of a near-IR spectrometer for ground-based observations of massive stars
Kintziger, Christian ULg; Desselle, Richard ULg; Loicq, Jerôme ULg et al

Poster (2016, June 27)

In our contribution, we outline the different steps in the design of a fiber-fed spectrographic instrument that intends to observe massive stars. Starting from the derivation of theoretical relationships ... [more ▼]

In our contribution, we outline the different steps in the design of a fiber-fed spectrographic instrument that intends to observe massive stars. Starting from the derivation of theoretical relationships from the scientific requirements and telescope characteristics, the entire optical design of the spectrograph is presented. Specific optical elements, such as a toroidal lens, are introduced to improve the instrument’s performances. Then, the verification of predicted optical performances is investigated through optical analyses such as resolution checking. Eventually, the star positioning system onto the central fiber core is explained. [less ▲]

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See detailHealth Literacy: Eduquer pour mieux soigner
Bragard, Isabelle ULg

Scientific conference (2016, June 24)

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See detailMarijan Molé à l'aude du nouveau comparatisme indo-iranien
Swennen, Philippe ULg

Conference (2016, June 24)

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See detailReceding-Horizon Control of Distributed Generation to Correct Voltage or Thermal Violations and Track Desired Schedules
Soleimani Bidgoli, Hamid ULg; Glavic, Mevludin ULg; Van Cutsem, Thierry ULg

in Proceedings of the 19th PSCC (2016, June 23)

This paper presents a real-time, centralized control system acting on the active and reactive powers of distributed generators when the network experiences voltage and/or thermal limits violation. The ... [more ▼]

This paper presents a real-time, centralized control system acting on the active and reactive powers of distributed generators when the network experiences voltage and/or thermal limits violation. The control resorts on multi-step receding-horizon optimization. The objective is to minimize the deviations of Dispersed Generation Units (DGU) active and reactive powers from reference values. The reactive power corrections have priority over the active ones. Furthermore, the formulation is such that DGU powers are restored to their desired schedule as soon as operating conditions allow doing so. Three modes of operation of the proposed controller are presented, involving dispatchable units as well as DGUs operated to track maximum power output. The effectiveness of the proposed control is illustrated through detailed simulations of a 75-bus, 11-kV system hosting 22 DGUs. [less ▲]

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See detailOrganic Rankine cycle modelling and the ORCmKit library: analysis of R1234ze(Z) as drop-in replacement of R245fa for low-grade waste heat recovery
Davide, Ziviani; Dickes, Rémi ULg; Quoilin, Sylvain ULg et al

in Proceedings of ECOS 2016 (2016, June 20)

Due to the wide interest in organic Rankine cycles (ORCs) as a sustainable technology and the importance of numerical analyses and optimization procedures while considering such systems, we created a ... [more ▼]

Due to the wide interest in organic Rankine cycles (ORCs) as a sustainable technology and the importance of numerical analyses and optimization procedures while considering such systems, we created a dedicated open-source library named “ORC modelling Kit” (ORCmKit). The comprehensive library includes single com-ponents and overall models for subcritical, transcritical and supercritical ORCs. Three main programming environments are currently supported: Matlab, Python and EES (Engineering Equation Solver). A detailed steady-state cycle model of a small-scale regenerative ORC with a single-screw expander is used to evalu-ate the performance influence of R1234ze(Z) as a drop-in replacement of R245fa currently used in the instal-lation. The ORC system is used to recover low-grade waste heat with a temperature range between 90°C and 120°C. A thermal oil heater is used to simulate the heat source. A parametric study is carried out to in-vestigate the performance of the system throughout the range of interest in order to optimize the ORC with R1234ze(Z). [less ▲]

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See detailNovel Methods for the Detection of Functional Brain Activity using 17O MRI
Möllenhoff, Klaus ULg

Doctoral thesis (2016)

Detailed quantitative information about metabolic processes plays a crucial role in the potential cure and for treatment of many diseases such as Alzheimer’s disease or brain tumours. In the last decades ... [more ▼]

Detailed quantitative information about metabolic processes plays a crucial role in the potential cure and for treatment of many diseases such as Alzheimer’s disease or brain tumours. In the last decades, radioactive tracers such as 15O have been used to quantify CMRO2 with PET imaging and this is regarded as the gold standard. However, such methods are complicated and expensive as a consequence of the short half-life (2 min) of 15O and inherently include radiation exposure and invasive measurements such as blood probes to probe cerebral blood flow (CBF). Fick’s principle of arteriovenous oxygen difference [1] connects CMRO2 and CBF via the measure of oxygen extraction fraction (OEF). The main goal of this work is to achieve non-invasive measures of OEF based on magnetic resonance imaging (MRI) to quantify CMRO2 allowing straightforward and comfortable patient handling. MRI enables studies of large cohorts of healthy volunteers due to noninvasive measurements and a lack of radioactivity. This can be achieved first by quantitative relaxation time mapping of the transverse relaxation time (T2) of venous blood only in proton (1H) MRI or by a measurement following inhalation of 17O gas and recording the signal curve of directly detected 17O signal. Unfortunately, the most abundant isotope of oxygen (16O) has a zero spin system, and cannot be detected with NMR experiments. In contrast, 17O, a stable isotope with a half-integer spin (I=5/2), can be detected by MR. Fortuitously, however, in MRI it is only visible in the form of metabolically generated H17 2 O and not as a gas. The low natural abundance of 17O, of only 0.037% (of the oxygen atoms) and the low NMR sensitivity (2.9% that of 1H) gives rise to the need for ultra-high-field MRI to reach a significant SNR per unit time. Natural abundance images of a healthy male volunteer were acquired in vivo after having gained written consent within a clinical trial of a 9.4T MRI system (Siemens AG, Erlangen, Germany) [2, 3]. These natural abundance images, which reflect the 17O bound to protons as H17 2 O and thus, the amount of water, are compared to 1H-based quantitative water content imaging. For further studies, the voxelwise knowledge of the quantitative water content is necessary to quantify CMRO2 based on the 17O signal behaviour. To achieve that, methods which were originally used on 1.5T scanners had to be adapted for the use at higher field strengths to overcome RF field inhomogeneities [4–11]. New correction methods were developed based on a well known correlation between tissue T1 and proton density (PD) to estimate the receive bias field properly. These methods were tested for quantitative water content determination. Averaged results in grey (GM) and white matter (WM) respectively of 10 healthy volunteers are H2OWM=70.3 1.4 %, H2OGM=84.7 1.5 %„ T1WM=918 24 ms and T1GM=1509 14 ms. Further, 1H-based imaging methods called QUIXOTIC [12–14] and TRUST [15] appeared in the literature. These methods are based on changes of the proton transverse relaxation rate T2 with different oxygen saturation levels. Quantitative values of venous blood T2 were acquired using a so-called T2prep module or a multi-echo spin echo readout. While the first method suffers from long acquisition times the latter one from large echo-spacing of the spin echoes and stimulated echo effects. Both disadvantages were overcome using an adiabatic multi-shot multi-echo spin echo sequence, which does not suffer from stimulated echo effects and due to the multi-shot capabilities, the echo-spacing is reduced [16]. Mean values in GM of four healthy volunteers are found to be venous oxygenation Yv=0.61 0.03, T2=54 4 ms, CMRO2=174 13 mol/100g min and CBF=53 3 ml/100g min. [less ▲]

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See detail"World of Chemistry" : Gamification d'activités d'entrainement en chimie générale"
le Maire, Nathalie ULg

Scientific conference (2016, June 17)

Présentation et évaluation du potentiel de quatre mini-jeux développés dans le cours de chimie générale en Bac 1 en vue d'augmenter la fréquentation de la matière par les étudiants.

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See detailSerious Game Biotechnologie: dans la peau d'un responsable de laboratoire de diagnostic
Massart, Sébastien ULg

Scientific conference (2016, June 17)

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See detailLe rôle du Système européen des comptes nationaux et régionaux (SEC) dans la gouvernance budgétaire européenne
Piron, Damien ULg

Conference given outside the academic context (2016)

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