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See detailOutcomes of adults with active or progressive hematological malignancies at time of allogeneic stem cell transplantation : a survey from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Chevallier, P.; Labopin, M.; Milpied, N. et al

in Bone Marrow Transplantation (2014), 49

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective ... [more ▼]

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective study aimed to analyze the outcome of adult patients who received allo-SCT in a chemo-refractory/relapsed status. The series included 840 patients with active or progressive disease at the time of transplant. Median age was 50 years. With a median follow-up of 40 months, 3-year OS, disease-free survival (DFS), and non-relapse mortality rates were 29±2, 23±2, and 30±2%, respectively. At the last follow-up, 252 patients (30%) were still alive (of whom 201 were in CR (24%). In a Cox multivariate analysis, the use of a reduced-intensity conditioning (RIC) before allo-SCT and use of an HLA-identical sibling donor remained independently associated with a better OS (hazard ratio (HR)¼0.82; 95% confidence interval (CI), 0.69–0.98, P¼0.03; and HR¼0.79; 95% CI, 0.66–0.93, P¼0.006, respectively). Also, a diagnosis of myelodysplastic syndrome/myeloproliferative disorder, Hodgkin lymphoma and non-Hodgkin lymphoma compared with acute leukemia had a favorable impact on OS (HR¼0.55; 95% CI, 0.45–0.68, Po0.0001; HR¼0.49; 95% CI, 0.31–0.75, P¼0.001; and HR¼0.47; 95% CI, 0.35–0.63, Po0.0001, respectively). In conclusion, this study suggests that allo-SCT may be of benefit in some subgroups of patients with active or progressive hematological malignancies at the time of allo-SCT. [less ▲]

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See detailDisney, Danse, Dessin. Une conception chorégraphique de l'animation
Tomasovic, Dick ULg

in Cahiers Robinson (2014), 35

Réflexions sur la conception de l'animation de Walt Disney et approche des productions des studios Disney à travers des catégories conceptuelles issues de l'art chorégraphique.

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See detailIdentités du mouvement : motion capture et kinesthésie
Tomasovic, Dick ULg

in Grosoli, Marco; Massuet, Jean-Baptiste (Eds.) La Capture de mouvement ou le modelage de l'invisible (2014)

En analysant une série de productions contemporaines recourant au procédé de la motion capture (« Real Steel »,« Planet of Apes, the Origins », « Hulk », « The Adventures of Tintin » …), cet article ... [more ▼]

En analysant une série de productions contemporaines recourant au procédé de la motion capture (« Real Steel »,« Planet of Apes, the Origins », « Hulk », « The Adventures of Tintin » …), cet article propose de cerner les implications de la kinesthésie (l’ensemble des sensations relatives au mouvement du corps) comme processus d’identification. Par ailleurs, cette étude tend à montrer que ces films réfléchissent (au sens de refléter) leurs conditions de possibilité technologiques et permettent de développer une réflexion autour de la technologie qui les conditionne. [less ▲]

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See detailCaractéristiques de reproduction de la femelle trypanotolérante de race N’Dama.
Okouyi, Marcel; Kamga Waladjo, Alain; Diarra, S et al

in Revue Africaine de Santé et de Productions Animales [=RASPA] (2014), 12(1), 3-7

Knowledge about the reproductive N’Dama remain old and very general, observations have been most often performed on a limited number of animals and in different contexts. This inventory confirms the need ... [more ▼]

Knowledge about the reproductive N’Dama remain old and very general, observations have been most often performed on a limited number of animals and in different contexts. This inventory confirms the need to continue and intensify so as federated possible studies to further clarify the characteristcs and reproductive performance of this important development potential of cattle that represents the N’Dama to Africa. [less ▲]

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See detailNew role for Emerin, a key inner nuclear membrane protein, as an enhancer of the autophagosome formation in the C16-ceramide autophagy pathway.
Deroyer, Céline ULg; Renert, Anne-Françoise; Merville, Marie-Paule ULg et al

in Autophagy (2014)

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in ... [more ▼]

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in the regulation of cell growth, differentiation or cell death. However, the mechanisms by which they mediate these pathways are not fully understood. We found that C16-ceramide induces EMD phosphorylation on its LEM domain through PRKACA. Upon ceramide treatment, phosphorylated EMD binds LC3 leading to an increase of the autophagosomes formation. These data suggest a new role of EMD as an enhancer of autophagosomes formation in the C16-ceramide autophagy pathway in colon cancer cells. [less ▲]

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See detailVisual neglect: Is there a relationship between impaired spatial working memory and re-cancellation?
Wansard, Murielle ULg; Meulemans, Thierry ULg; Gillet, Sophie ULg et al

in Experimental Brain Research (2014), 232(10), 3333-3343

In visual search tasks, neglect patients tend to explore and repeatedly re-cancel stimuli on the ipsilesional side, as if they did not realize that they had previously examined the rightward locations ... [more ▼]

In visual search tasks, neglect patients tend to explore and repeatedly re-cancel stimuli on the ipsilesional side, as if they did not realize that they had previously examined the rightward locations favoured by their lateral bias. The aim of this study was to explore the hypothesis that a spatial working memory deficit explains these ipsilesional re-cancellation errors in neglect patients. For the first time, we evaluated spatial working memory and re-cancellation through separate and independent tasks in a group of patients with right hemisphere damage and a diagnosis of left neglect. Results showed impaired spatial working memory in neglect patients. Compared to the control group, neglect patients cancelled fewer targets and made more re-cancellations both on the left side and on the right side. The spatial working memory deficit appears to be related to re-cancellations, but only for some neglect patients. Alternative interpretations of re-exploration of space are discussed. [less ▲]

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See detailZelfbehandeling van frequente hoofdpijn : een Belgische apotheekstudie
Mehuys, E; Paemeleire, K; Van Hees, Thierry ULg et al

Conference (2014)

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See detailAssessment of Patient Comfort During Palliative Sedation: Is it always Reliable?
Deschepper, R; Bilsen, J; Laureys, Steven ULg

in Annual Update in Intensive Care and Emergency Medicine (2014)

"When death knocks at the door of our ward, we do not easily open the door”, an intensivist once said. In the intensive care unit (ICU) and emergency department, care is strongly focused on cure and ... [more ▼]

"When death knocks at the door of our ward, we do not easily open the door”, an intensivist once said. In the intensive care unit (ICU) and emergency department, care is strongly focused on cure and resuscitation. Notwithstanding the technological progress made in intensive and emergency medicine, a substantial number of the patients admitted to the ICU cannot be saved. In these cases, it is important to make a timely shift from curative efforts to palliative care, so that futile and burdensome interventions can be avoided. When death becomes imminent, a major concern of the family members and caregivers is to assure maximal comfort during the dying process. A central aspect of good end-of-life care is to keep the patient, as much as possible, free of pain and other kinds of distress. However, many critically ill patients often suffer from symptoms such as pain and delirium. More than 50 % of critically ill patients in the ICU experience moderate to severe pain and pain in critically ill patients often remains untreated [1]. [less ▲]

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See detailPrimary production in a tropical large lake: The role of phytoplankton composition
Darchambeau, François ULg; Sarmento, Hugo; Descy, Jean-Pierre

in Science of the Total Environment (2014), 473-474

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See detailResidues management in silty soil : First assessment on crop production
Hiel, Marie-Pierre ULg; Olivier, Claire; Pierreux, Jérome ULg et al

Poster (2014)

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See detailDUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase
Amand, Mathieu ULg; Erpicum, Charlotte ULg; BAJOU, Khalid ULg et al

in Molecular Cancer (2014)

Background DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies ... [more ▼]

Background DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies showed that DUSP3 is a negative regulator of ERK and JNK pathways in several cell lines. On the other hand, DUSP3 is implicated in human cancer. It has been alternatively described as having tumor suppressive and oncogenic properties. Thus, the available data suggest that DUSP3 plays complex and contradictory roles in tumorigenesis that could be cell type-dependent. Since most of these studies were performed using recombinant proteins or in cell-transfection based assays, the physiological function of DUSP3 has remained elusive. Results Using immunohistochemistry on human cervical sections, we observed a strong expression of DUSP3 in endothelial cells (EC) suggesting a contribution for this phosphatase to EC functions. DUSP3 downregulation, using RNA interference, in human EC reduced significantly in vitro tube formation on Matrigel and spheroid angiogenic sprouting. However, this defect was not associated with an altered phosphorylation of the documented in vitro DUSP3 substrates, ERK1/2, JNK1/2 and EGFR but was associated with an increased PKC phosphorylation. To investigate the physiological function of DUSP3, we generated Dusp3-deficient mice by homologous recombination. The obtained DUSP3-/- mice were healthy, fertile, with no spontaneous phenotype and no vascular defect. However, DUSP3 deficiency prevented neo-vascularization of transplanted b-FGF containing Matrigel and LLC xenograft tumors as evidenced by hemoglobin (Hb) and FITC-dextran quantifications. Furthermore, we found that DUSP3 is required for b-FGF-induced microvessel outgrowth in the aortic ring assay. Conclusions All together, our data identify DUSP3 as a new important player in angiogenesis. [less ▲]

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See detailAb initio calculation of the thermal conductivity of indium antimonide
Miranda, Alonso L.; Xu, Bin ULg; Hellman, Olle et al

in Semiconductor Science and Technology (2014), 29(12), 124002

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See detailAre Hydrogen-Bonded Charge Transfer Crystals Room Temperature Ferroelectrics?
D'Avino, Gabriele ULg; Verstraete, Matthieu ULg

in Physical Review Letters (2014), 113

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See detailUnderstanding the performance of the FLake model over two African Great Lakes
Thiery, Wim; Martynov, Andrey; Darchambeau, François ULg et al

in Geoscientific Model Development [=GMD] (2014), 7

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See detailLakeMIP Kivu: evaluating the representation of a large, deep tropical lake by a set of one-dimensional lake models
Thiery, Wim; Stepanenko, Victor M.; Fang, Xing et al

in Tellus : Series A (2014), 66

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See detailArchivage papier et/ou électronique et accès pérenne aux ressources documentaires électroniques en texte intégral en Fédération Wallonie-Bruxelles
Alexandre, Aude ULg

Report (2014)

Le présent rapport avait pour objectif d’éclairer les choix de la BICfB en matière d’archivage pérenne des périodiques électroniques, en examinant en particulier les conditions contractuelles des ... [more ▼]

Le présent rapport avait pour objectif d’éclairer les choix de la BICfB en matière d’archivage pérenne des périodiques électroniques, en examinant en particulier les conditions contractuelles des abonnements en cours et les solutions tierces d’archivage existantes (LOCKSS, CLOCKSS, Portico), en évaluant le coût des solutions envisagées, en articulant ces solutions avec l’archivage papier et en proposant des scénarios d’application. Il propose en conclusion une échelle de solutions garantissant l’accès pérenne aux périodiques électroniques, en distinguant une stratégie prioritaire, basée sur la participation à la LOCKSS Alliance, la présence de clauses garantissant l’accès aux titres sur la plateforme éditeur en cas de transfert, de cessation de publication ou de fin d’abonnement, et la prise en compte de l’archivage via CLOCKSS, et des pistes complémentaires, plus diverses et plus ou moins coûteuses, à sélectionner au cas par cas en fonction d’éléments externes et d’analyse coûts-bénéfices, pour garantir la préservation pérenne du portefeuille non couvert par le premier scénario. [less ▲]

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See detailFirst-principles study of vibrational and noncollinear magnetic properties of the perovskite to postperovskite pressure transition of $NaMnF_3$
Garcia Castro, Andrés Camilo ULg; Romero, A. H.; Bousquet, Eric ULg

in Physical Review. B, Condensed Matter and Materials Physics (2014), 90

We performed a first-principles study of the structural, vibrational, electronic, and magnetic properties of NaMnF3 under applied isotropic pressure. We found that NaMnF3 undergoes a reconstructive phase ... [more ▼]

We performed a first-principles study of the structural, vibrational, electronic, and magnetic properties of NaMnF3 under applied isotropic pressure. We found that NaMnF3 undergoes a reconstructive phase transition at 8 GPa from the Pnma distorted perovskite structure toward the Cmcm postperovskite structure. This is confirmed by a sudden change of the Mn-F-Mn bondings where the crystal goes from corner-shared octahedra in the Pnma phase to edge-shared octahedra in the Cmcm phase. The magnetic ordering also changes from a G-type antiferromagnetic ordering in the Pnma phase to a C-type antiferromagnetic ordering in the Cmcm phase. Interestingly, we found that the high-spin d-orbital filling is kept at the phase transition which has never been observed in the known magnetic postperovskite structures. We also found a highly noncollinear magnetic ordering in the Cmcm postperovskite phase that drives a large ferromagnetic canting of the spins. We discuss the validity of these results with respect to the U and J parameters of the GGA+U exchange-correlation functional used in our study and conclude that large-spin canting is a promising property of the postperovskite fluoride compounds. [less ▲]

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See detailÉtablissement de scénarios alternatifs de valorisations alimentaires et non alimentaires des ressources céréalières wallonnes à l’horizon 2030
Van Stappen, Florence; Delcour, Alice; Gheysens, Stéphanie et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2), 193-208

Based on the current uses of cereals grown in Wallonia (Belgium), various scenarios defining possible futures for the Walloon cereal sector have been created.

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