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See detailLes forêts vierges du Bassin du Congo - mythe ou réalité ?
Morin-Rivat, Julie ULg; Bourland, Nils ULg; Gillet, Jean-François ULg et al

Scientific conference (2013, March 21)

Les forêts du bassin du Congo ont longtemps été considérées comme des massifs historiquement épargnés par l'action de l'homme. Des résultats plus ou moins récents de recherches scientifiques remettent en ... [more ▼]

Les forêts du bassin du Congo ont longtemps été considérées comme des massifs historiquement épargnés par l'action de l'homme. Des résultats plus ou moins récents de recherches scientifiques remettent en question cette vision des forêt denses humides africaines. [less ▲]

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See detailRetrospective analysis of Belgian experience with intestinal transplantation
Ceulemans, L.J.; DE ROOVER, Arnaud ULg; DETRY, Olivier ULg et al

Conference (2013, March 21)

Aim: The only alternative to Total Parenteral Nutrition (TPN) for complicated intestinal failure is Intesti- nal Transplantation (ITx) which is perceived as a high-risk procedure with inferior results ... [more ▼]

Aim: The only alternative to Total Parenteral Nutrition (TPN) for complicated intestinal failure is Intesti- nal Transplantation (ITx) which is perceived as a high-risk procedure with inferior results compared to other organ Tx. Therefore ITx has been rarely applied in Belgium. In a multicenter retrospective review, we analyzed the overall Belgian experience with ITx. Methods: The Belgium Liver Intestine Committee organized a survey among all Belgian Tx centers, based on the patient-specific data form of the international ITx registry. Overall activity and indications were reviewed. Patient/graft survival was calculated (Kaplan-Meier). Nutritional (TPN) independence and Quality of Life (QoL) (Karnofsky score) were analyzed. Results: 21 ITx were performed in 20 patients (03/99-11/12), distributed among 5 centers: KUL (12), ULg (5), UZG (2), UCL (1), UZA (1). Median age was 38y(8mo-56y). Male/female ratio was 10/10. 5 were pediatrics (<18y) and 15 adults. Indications were anatomical or functional short bowel syndrome: intestinal ischemia(5), volvulus(5), Crohn(2), chronic intestinal pseudo-obstruction(2), splanchnic thrombosis(2), Churg-Strauss(1), necrotizing enterocolitis(1), microvillus inclusion(1), intestinal atresia(1) and chronic rejection of a first ITx(1). Most patients also suffered from TPN-associated com- plications (infection/shortage of venous access or liver failure). An isolated small bowel was trans- planted in 9 patients (plus kidney Tx in 2; plus pancreas Tx in 1); 10 received a combined liver and ITx; 2 received a multivisceral Tx. At time of Tx, 11 patients were hospitalized and 10 at home. 20 grafts were procured from deceased donors; one segmental intestinal graft was procured from a living donor. ABO blood group was identical in 63%, compatible in 37%. Median cold ischemia time was 5h30 ́(3h17 ́-9h31 ́). All patients received tacrolimus-based immunosuppression. Basiliximab (anti-IL2 receptor antibody) induction was administered in 16 patients. In 11 patients donor specific blood was transfused as part of an immunomodulatory protocol. 5-year patient and graft survival is 59% and 55.6%, respectively. 8 patients died: 6 to sepsis, 1 to intracerebral hemorrhage; 1 sudden death re- mained unexplained. 1 patient developed postTx lymphoma. 2 chronic rejections occured for which one reTx was performed. Of 12 survivors (median follow-up 1870 days), 11 are nutritionally independent (TPN-free) and 10 have a Karnofsky score >90%. Conclusions: ITx has come of age in Belgium. During the last 13 years, 21 ITx were performed in 5 centers. A 5-year patient/graft survival of 59%/55.6% is achieved, which is similar to results reported by the International ITx registry. In Belgium, awareness should grow that ITx represents a life-saving (and QoL improving) treatment in selected patients with reduced life expectancy due to significant complica- tions from TPN and intestinal failure. [less ▲]

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See detailHot stars in the whole CoRoT mission
Briquet, Maryline ULg

Conference (2013, March 20)

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See detailUltradian and circadian modulation of dream recall: EEG correlates and age effects
Chellappa, Sarah Laxhmi ULg; Cajochen, Christian

in International Journal of Psychophysiology (2013)

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See detailValorisation de l'épeautre dans l'alimentation des bovins
Beckers, Yves ULg

Scientific conference (2013, March 19)

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See detailMultifractality of quantum wave functions
Martin, John ULg; Garcia-Mata, Ignacio; Giraud, Olivier et al

Poster (2013, March 19)

We study the multifractality of individual wave packets in a periodically kicked system through a combination of numerical and analytical works. We consider a version of the mathematical Ruijsenaars ... [more ▼]

We study the multifractality of individual wave packets in a periodically kicked system through a combination of numerical and analytical works. We consider a version of the mathematical Ruijsenaars-Schneider model and reinterpreted it physically in order to describe the spreading with time of quantum wave packets in a system where multifractality can be tuned by varying a parameter [1]. We compare different methods to measure the multifractality of wave packets and identify the best one. We find the multifractality to decrease with time until it reaches an asymptotic limit, which is different from the multifractality of eigenvectors but related to it, as is the rate of the decrease. Our results could guide the study of experimental situations where multifractality is present in quantum systems. [less ▲]

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See detailSelf-Defining Memories and Identity in Schizophrenia: Preliminary Results.
Boulanger, Marie ULg; Marchal Laurie; Blairy, Sylvie ULg

Poster (2013, March 18)

The reciprocal relationship between autobiographical memory (AM) and identity is well known. In schizophrenia, there is evidence that both identity and AM are impaired. Indeed, identity has been described ... [more ▼]

The reciprocal relationship between autobiographical memory (AM) and identity is well known. In schizophrenia, there is evidence that both identity and AM are impaired. Indeed, identity has been described as fragmented, instable or still discontinuous in these patients (Boulanger et al., submitted; deBonis et al., 1995; Nieznanski, 2004). Further, schizophrenia patients’ (SCh) AM impairments were described as difficulties to retrieve specific memories (Cuervo-Lombard et al., 2007; D’argembeau et al., 2008; Neumann et al., 2007; Wood et al., 2006). SCh have specificity impairment for mill run autobiographical memories (AMs) and also, for AMs particularly important for construction and continuity to identity as self-defining memories (SDMs; Benounna-Greene, 2001; Raffard et al., 2009, 2010; Robinson and Taylor, 1998). SDMs have been particularly relevant in understanding the relationship between the identity and AM. Identity emerges during late adolescence and early adulthood period called “remimiscence bump period” because, it is characterized by a profusion of recalled memories in comparison to others periods of life span. Possibly, many memories from this period are of SDMs (Singer & Salovey, 1993) and have a powerful effect in binding the identity to a specific reality. Consequently, we supposed that identity impairments showed by SCch are related to SDMs deficits. 19 SCh and 19 healthy controls paired participated to this study. They were asked to give ten enduring “I am” statements that they felt “defined their identity.” Then, they selected the three statements among the ten, which are the “most personally significant to their sense of identity”. They were asked to recall three SDMs by each of three statements selected. Afterwards, they were asked to give: (1) their age for each statement when they felt it was a significant part of their identity, (2) their age at the time that the remembered event occurred. In parallel, the participants were completed neuropsychological measures, BDI-II, PANSS and, an identity stability measure. The results are discussed on the light of previous research [less ▲]

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See detailAssessment of localisation to auditory stimulation in post-comatose states: Use the patient's own name
Cheng, L; Gosseries, Olivia ULg; Ying, L et al

in BMC Neurology (2013), Vol 13

Background: At present, there is no consensus on how to clinically assess localisation to sound in patients recovering from coma. We here studied auditory localisation using the patient's own name as ... [more ▼]

Background: At present, there is no consensus on how to clinically assess localisation to sound in patients recovering from coma. We here studied auditory localisation using the patient's own name as compared to a meaningless sound (i.e., ringing bell).Methods: Eighty-six post-comatose patients diagnosed with a vegetative state/unresponsive wakefulness syndrome or a minimally conscious state were prospectively included. Localisation of auditory stimulation (i.e., head or eyes orientation toward the sound) was assessed using the patient's own name as compared to a ringing bell. Statistical analyses used binomial testing with bonferroni correction for multiple comparisons.Results: 37 (43%) out of the 86 studied patients showed localisation to auditory stimulation. More patients (n=34, 40%) oriented the head or eyes to their own name as compared to sound (n=20, 23%; p<0.001).Conclusions: When assessing auditory function in disorders of consciousness, using the patient's own name is here shown to be more suitable to elicit a response as compared to neutral sound [less ▲]

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See detailMicrobiological diagnosis of infectious keratitis
MELIN, Pierrette ULg

Conference (2013, March 16)

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See detailAutomatic Aircraft Cargo Load Planning with Pick-up and Delivery
Lurkin, Virginie ULg; Schyns, Michael ULg

Conference (2013, March 15)

This research aims to develop a new mixed integer linear program to solve the containers assignment problem when pickup and deliveries are considered. Given a pool of ULDs and an aircraft with multiple ... [more ▼]

This research aims to develop a new mixed integer linear program to solve the containers assignment problem when pickup and deliveries are considered. Given a pool of ULDs and an aircraft with multiple destinations, we want to obtain a loading plan determining at which positions the ULDs must be assigned in order to minimize simultaneous the quantity of fuel consumed and the number of re-handles. The loading plan should also ensure a number of structural, safety and manoeuvrability constraints. The model has been tested on real instances and provides encouraging results. [less ▲]

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See detailAllosteric inhibition of VIM metallo-beta-lactamase by a camelid nanobody
Sohier, Jean ULg; Laurent, Clémentine ULg; Chevigné, Andy et al

in Biochemical Journal (2013), 450(3), 477-486

Metallo-β-lactamase (MβL) enzymes are usually produced by multiresistant Gram-negative bacterial strains and have spread worldwide. An approach based on phage display was employed to select single-domain ... [more ▼]

Metallo-β-lactamase (MβL) enzymes are usually produced by multiresistant Gram-negative bacterial strains and have spread worldwide. An approach based on phage display was employed to select single-domain antibody fragments (VHHs also called Nanobodies) that would inhibit the clinically relevant VIM-4 MβL. Out of more than 50 selected nanobodies, only the NbVIM_38 nanobody inhibited VIM-4. The paratope, inhibition mechanism and epitope of NbVIM_38 nanobody were then characterised. An alanine scan of the NbVIM_38 paratope showed that its binding was driven by hydrophobic amino acids. The inhibitory concentration was in the µM range for all tested β-lactams. In addition, the inhibition was found to follow a mixed hyperbolic profile with a predominantly uncompetitive component. Moreover, substrate inhibition was recorded only after nanobody binding. These kinetic data are indicative of a binding site that is distant from the active site. This finding was confirmed by epitope mapping analysis that was performed using peptides, and which identified two stretches of amino acids in the L6 loop and at the end of the alpha2 helix. Because this binding site is distant from the active site and alters both the substrate binding and catalytic properties of VIM-4, this nanobody can be considered as an allosteric inhibitor. [less ▲]

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See detailExome sequencing of tumors: relevance in copy-number alteration (CNA) analysis and fixed tissue samples.
Wenric, Stéphane ULg; JOSSE, Claire ULg; Fasquelle, Corinne ULg et al

Poster (2013, March 15)

Genomic DNA has been extracted from both cryopreserved and formalin-fixed paraffin-embedded forms of 2 different tumor samples (triple negative, and Her2+). Exome sequencing has been performed on all 4 ... [more ▼]

Genomic DNA has been extracted from both cryopreserved and formalin-fixed paraffin-embedded forms of 2 different tumor samples (triple negative, and Her2+). Exome sequencing has been performed on all 4 forms, as well as SNP and CNA detection. A comparison of the various metrics and results related to the sequencing, mapping, and variants detection has been done, outlining what can, and can’t be done with exome data sequenced from cryopreserved and FFPE tissue. [less ▲]

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See detailDifficultés scolaires : comment améliorer la méthode de travail par l'Education cognitive
Frenkel, Stéphanie ULg

Scientific conference (2013, March 14)

De plus en plus d'élèves ont des difficultés liées à leur façon d'apprendre. Nombre d'entre eux présentent un point commun : ils n'ont pas pleinement développé leurs compétences métacognitives. L'élève n ... [more ▼]

De plus en plus d'élèves ont des difficultés liées à leur façon d'apprendre. Nombre d'entre eux présentent un point commun : ils n'ont pas pleinement développé leurs compétences métacognitives. L'élève n'exploite pas pleinement son potentiel d'apprentissage, il n'a pas développé un niveau suffisant de connaissances sur lui (ses points forts, ses points faibles, son style d'apprentissage ...) ni ses stratégies de haut niveau (anticipation, planification, contrôles et transfert). A cela, s'ajoutent des aspects psychoaffectifs aggravants (faibles objectifs d'apprentissage, faible estime de soi, démobilisation scolaire ...). Incluant une définition de la métacognition, il s'agira notamment d'étudier les actions possibles à l'aide d'outils et de méthodes notamment issus de l'Education cognitive. [less ▲]

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See detailIntérêts et limites de la dialyse nocturne
Krzesinski, Jean-Marie ULg

Conference (2013, March 14)

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See detailEstimating the Greenland ice sheet surface mass balance contribution to future sea level rise using the regional atmospheric climate model MAR
Fettweis, Xavier ULg; Franco, Bruno ULg; Tedesco, M. et al

in Cryosphere (The) (2013), 7

To estimate the sea level rise (SLR) originating from changes in surface mass balance (SMB) of the Greenland ice sheet (GrIS), we present 21st century climate projections obtained with the regional ... [more ▼]

To estimate the sea level rise (SLR) originating from changes in surface mass balance (SMB) of the Greenland ice sheet (GrIS), we present 21st century climate projections obtained with the regional climate model MAR (Modèle Atmosphérique Régional), forced by output of three CMIP5 (Coupled Model Intercomparison Project Phase 5) general circulation models (GCMs). Our results indicate that in a warmer climate, mass gain from increased winter snowfall over the GrIS does not compensate mass loss through increased meltwater run-off in summer. Despite the large spread in the projected near-surface warming, all the MAR projections show similar non-linear increase of GrIS surface melt volume because no change is projected in the general atmospheric circulation over Greenland. By coarsely estimating the GrIS SMB changes from GCM output, we show that the uncertainty from the GCM-based forcing represents about half of the projected SMB changes. In 2100, the CMIP5 ensemble mean projects a GrIS SMB decrease equivalent to a mean SLR of +4 ± 2 cm and +9 ± 4 cm for the RCP (Representative Concentration Pathways) 4.5 and RCP 8.5 scenarios respectively. These estimates do not consider the positive melt–elevation feedback, although sensitivity experiments using perturbed ice sheet topographies consistent with the projected SMB changes demonstrate that this is a significant feedback, and highlight the importance of coupling regional climate models to an ice sheet model. Such a coupling will allow the assessment of future response of both surface processes and ice-dynamic changes to rising temperatures, as well as their mutual feedbacks. [less ▲]

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See detailMigrant labour Culture in Post-Mao China
Florence, Eric ULg

in Books and Ideas (2013)

Against a backdrop of economic growth and growing spate of collective actions, rural migrant workers have developed narratives of migrant labour. This essay studies articles, diaries, poems and online ... [more ▼]

Against a backdrop of economic growth and growing spate of collective actions, rural migrant workers have developed narratives of migrant labour. This essay studies articles, diaries, poems and online songs asserting their collective subaltern identity and specific norms and values. [less ▲]

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See detailLa durabilité naturelle du bois d'oeuvre
Jourez, Benoît ULg

Scientific conference (2013, March 14)

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