Publications ORBi OA
Bookmark and Share    
Full Text
Peer Reviewed
See detailCompetitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila
Horsfall, L. E.; Garau, G.; Lienard, B. M. et al

in Antimicrobial Agents and Chemotherapy (2007), 51(6), 2136-2142

Various inhibitors of metallo-beta-lactamases have been reported; however, none are effective for all subgroups. Those that have been found to inhibit the enzymes of subclass B2 (catalytically active with ... [more ▼]

Various inhibitors of metallo-beta-lactamases have been reported; however, none are effective for all subgroups. Those that have been found to inhibit the enzymes of subclass B2 (catalytically active with one zinc) either contain a thiol (and show less inhibition towards this subgroup than towards the dizinc members of B1 and B3) or are inactivators behaving as substrates for the dizinc family members. The present work reveals that certain pyridine carboxylates are competitive inhibitors of CphA, a subclass B2 enzyme. X-ray crystallographic analyses demonstrate that pyridine-2,4-dicarboxylic acid chelates the zinc ion in a bidentate manner within the active site. Salts of these compounds are already available and undergoing biomedical testing for various nonrelated purposes. Pyridine carboxylates appear to be useful templates for the development of more-complex, selective, nontoxic inhibitors of subclass B2 metallo-beta-lactamases. [less ▲]

Detailed reference viewed: 16 (1 ULg)
Full Text
See detailOral contraception and lipid peroxidation
De Groote, D.; Pincemail, Joël ULg; Defraigne, Jean-Olivier ULg et al

in Clinical Chemistry (2007, June), 53(6, Suppl. S), 30-30

Detailed reference viewed: 9 (3 ULg)
Full Text
Peer Reviewed
See detailCerebral asymmetries in sleep-dependent processes of memory consolidation
Peigneux, Philippe ULg; Schmitz, Remy; Willems, Sylvie ULg

in Learning & Memory (2007), 14(6), 400-406

Preference for previously seen, unfamiliar objects reflects a memory bias on affective judgment, known as the "mere exposure effect" (MEE). Here, we investigated the effect of time, post-exposure sleep ... [more ▼]

Preference for previously seen, unfamiliar objects reflects a memory bias on affective judgment, known as the "mere exposure effect" (MEE). Here, we investigated the effect of time, post-exposure sleep, and the brain hemisphere solicited on preference generalization toward objects viewed in different perspectives. When presented in the right visual field (RVF), which promotes preferential processing in the left hemisphere, same and mirrored exemplars were preferred immediately after exposure. MEE generalized to much dissimilar views after three nights of sleep. Conversely, object presentation in the left visual field (LVF), promoting right hemisphere processing, elicited a MEE for same views immediately after exposure, then for mirror views after sleep. Most importantly, sleep deprivation during the first post-exposure night, although followed by two recovery nights, extinguished MEE for all views in the LVF but not in the RVF. Besides demonstrating that post-exposure time and sleep facilitate the generalization process by which we integrate various representations of an object, our results suggest that mostly in the right hemisphere, sleep may be mandatory to consolidate the memory bias underlying affective preference. These interhemispheric differences tentatively call for a reappraisal of the role of cerebral asymmetries in wake- and sleep-dependent processes of memory consolidation. [less ▲]

Detailed reference viewed: 44 (2 ULg)
Full Text
Peer Reviewed
See detailForm@HETICE : une étude de cas vue sous l'angle de la théorie des communautés de pratique
Milstein, A.; Denis, Brigitte ULg

in Actes du Colloque EIAH 2007 : International Workshop "Learning and working in CoPs : theoretical and technological issue" (2007, June)

La notion de communauté de pratique peut jouer un rôle important dans une nouvelle réflexion sur l’apprentissage. De nombreuses théories sur le sujet se multiplient dans la littérature. Néanmoins, comme ... [more ▼]

La notion de communauté de pratique peut jouer un rôle important dans une nouvelle réflexion sur l’apprentissage. De nombreuses théories sur le sujet se multiplient dans la littérature. Néanmoins, comme le soulignent Dameron et Josserand (2005), il manque une analyse processuelle du développement des communautés de pratique. Il existe un décalage réel entre la richesse conceptuelle des travaux sur cette forme d’organisation et le peu d’études en profondeur sur la dynamique de ce type de groupes, les « phases » de leur développement ainsi que sur l’impact effectif du partage des pratiques. Un certain nombre d’enquêtes (Dameron & Josserand, 2005 ; Cappe, 2005 ; Laferrière, 2005) ont déjà été réalisées. Notre travail entre dans cette démarche de validation du concept de communauté de pratique. Nous présentons ici une étude de cas : le projet Form@HETICE. Cet article décrit notre travail d’observation de la situation actuelle et d’identification de l’existence ou non de communautés de pratique au sein de ce projet. [less ▲]

Detailed reference viewed: 95 (1 ULg)
Full Text
See detailPlan communautaire opérationnel - Vaccination
Swennen, Béatrice; Miermans, Marie-Christine ULg; Levie, Karin

in Education Santé (2007), (224), 12-14

Detailed reference viewed: 45 (23 ULg)
Full Text
See detailOn two unsolved problems in probability
Swan, Yvik ULg

Doctoral thesis (2007)

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailPREDetector: A new tool to identify regulatory elements in bacterial genomes
Hiard, Samuel ULg; Marée, Raphaël ULg; Colson, Séverine ULg et al

in Biochemical and Biophysical Research Communications (2007), 357(4), 861-864

In the post-genomic area, the prediction of transcription factor regulons by position weight matrix-based programmes is a powerful approach to decipher biological pathways and to modelize regulatory ... [more ▼]

In the post-genomic area, the prediction of transcription factor regulons by position weight matrix-based programmes is a powerful approach to decipher biological pathways and to modelize regulatory networks in bacteria. The main difficulty once a regulon prediction is available is to estimate its reliability prior to start expensive experimental validations and therefore trying to find a way how to identify true positive hits from an endless list of potential target genes of a regulatory protein. Here we introduce PREDetector (Prokaryotic Regulatory Elements Detector), a tool developed for predicting regulons of DNA-binding proteins in bacterial genomes that, beside the automatic prediction, scoring and positioning of potential binding sites and their respective target genes in annotated bacterial genomes, it also provides an easy way to estimate the thresholds where to find reliable possible new target genes. PREDetector can be downloaded freely at http://www.montefiore.ulg.ac.be/-hiard/PreDetector (c) 2007 Published by Elsevier Inc. [less ▲]

Detailed reference viewed: 95 (31 ULg)
Full Text
Peer Reviewed
See detailLeast Cost Optimization of Large Passenger Vessels
Richir, Thomas; Caprace, Jean-David ULg; Losseau, Nicolas ULg et al

in Ships & Offshore Structures (2007), 2

The LBR-5 software allows optimizing ship structures according to objectives of higher inertia, less weight and/or lower cost. This last criterion offers the choice between two approaches of calculation ... [more ▼]

The LBR-5 software allows optimizing ship structures according to objectives of higher inertia, less weight and/or lower cost. This last criterion offers the choice between two approaches of calculation. The first approach is based on a simplified assessment of the cost in which the total cost is described by rather simple analytical functions which bring into play on the one hand the design variables and on the other hand empirical parameters. In the second approach, the calculation of the cost is based on data specific to the shipyard. The material cost is analyzed according to the first approach while the cost of the labor considers each relevant operation of the ship building with respect to the LBR-5 model. A survey of all the tasks was carried out at Aker Yards France, and a thorough study made it possible to develop assessment tools of the labor cost for each operation as functions of the design variables. Plate straightening operations are also considered in this analysis. This paper presents a cost-based optimization study carried out on a large passenger ship structure with more than 600 design variables, by the use of the detailed approach for the cost calculation. The structural model has been formulated on the basis of technical documentation prepared by Aker Yards France. The loads and strength criteria applied on the model are considered according to classification society rules (Bureau Veritas). Results and conclusions of the study are presented. [less ▲]

Detailed reference viewed: 158 (15 ULg)
Full Text
Peer Reviewed
See detailMeasurements of thermal effects in a bulk YBCO single domain superconductor submitted to a variable magnetic field
Laurent, Philippe ULg; Vanderbemden, Philippe ULg; Meslin, S. et al

in IEEE Transactions on Applied Superconductivity (2007), 17(2, Part 3), 3036-3039

When YBCO single domains are subjected to a variable magnetic field, the motion of vortices may give rise to a significant temperature increase and a degradation of the superconducting properties. We have ... [more ▼]

When YBCO single domains are subjected to a variable magnetic field, the motion of vortices may give rise to a significant temperature increase and a degradation of the superconducting properties. We have experimentally investigated such effects in bulk melt-processed YBCO single domains. Several temperature sensors, a pick-up coil and two Hall probes were placed against the surface of a monolithic bulk YBCO pellet. Data were simultaneously recorded during the application of ac magnetic fields of various amplitudes, either with or without a pre-existing dc trapped flux. The measurement results agree well with to those obtained by numerical modeling. It was also found that a superimposed dc magnetic moment reduces the temperature increase caused by the ac magnetic field. (C) 2003 IEEE. [less ▲]

Detailed reference viewed: 65 (26 ULg)
Full Text
Peer Reviewed
See detailThe importance of accurate lymph node staging in early and locally advanced non-small cell lung cancer: An update on available techniques
Kim, E. S.; Bosquee, Léon ULg

in Journal of Thoracic Oncology (2007), 2(6, Suppl. S), 59-67

Medical oncologists are faced with multiple factors to consider when staging a patient with suspected or confirmed non-small cell lung cancer (NSCLC). Identifying pathological nodal (N2) disease is ... [more ▼]

Medical oncologists are faced with multiple factors to consider when staging a patient with suspected or confirmed non-small cell lung cancer (NSCLC). Identifying pathological nodal (N2) disease is, however, of great importance because its presence significantly affects outcomes and potential treatment strategies. Recent data supporting the use of adjuvant or neoadjuvant therapies in these patients suggests that every reasonable effort should be made to assess the lymph node status accurately in patients with clinical early stage disease as well as in those with clinically staged N2 disease who have undergone preoperative treatments. Newer procedures such as integrated positron emission tomography computed tomography and esophageal or endobronchial endoscopic ultrasound with fine needle aspiration are mininially invasive techniques that may enhance the accuracy of mediastinal staging, traditionally devoted to mediastinoscopy. As their availability widens, they are likely to become an important part of staging and treatment paradigms. Intraoperatively, a growing body of evidence Suggests that lymph node dissection can be performed safely, and should replace sampling as a more effective means of identifying unsuspected N2 disease. This paper will review the current literature on staging NSCLC with regard to the detection of I nodal disease through preoperative staging of the mediastinum, the use of intraoperative lymph node sampling or dissection at the time of resection, and procedures for use in restaging patients with clinical stage IIIA N2 disease who have undergone preoperative chemotherapy (with or without radiotherapy). [less ▲]

Detailed reference viewed: 138 (5 ULg)
Full Text
Peer Reviewed
See detailInequalities from two rows of the simplex tableau
Andersen, Kent; Louveaux, Quentin ULg; Weismantel, Robert et al

in Fischetti, Matteo; David P., Williamson (Eds.) Integer Programming and Combinatorial Optimization, 12th International IPCO Conference, Ithaca, NY, USA, June 25-27, 2007, Proceedings. (2007, June)

In this paper we explore the geometry of the integer points in a cone rooted at a rational point. This basic geometric object allows us to establish some links between lattice point free bodies and the ... [more ▼]

In this paper we explore the geometry of the integer points in a cone rooted at a rational point. This basic geometric object allows us to establish some links between lattice point free bodies and the derivation of inequalities for mixed integer linear programs by considering two rows of a simplex tableau simultaneously. [less ▲]

Detailed reference viewed: 144 (14 ULg)
Full Text
Peer Reviewed
See detailLe galop des conducteurs. Etat de l'art.
Lilien, Jean-Louis ULg

in Electra (2007), 232

Power line galloping is a large vibration (up to the sag) at very low frequency (fraction of Hz) occuring on power line spans under heavy wind and cold temperature, with ice/snow deposit. Galloping is due ... [more ▼]

Power line galloping is a large vibration (up to the sag) at very low frequency (fraction of Hz) occuring on power line spans under heavy wind and cold temperature, with ice/snow deposit. Galloping is due to aerodynamic or aeroelastic instability. It may cause dramatic damages on conductor, hardware and towers. [less ▲]

Detailed reference viewed: 46 (2 ULg)
Full Text
See detailLa répression du négationnisme en Belgique : perspective systémique d'un blocage
Grandjean, Geoffrey ULg

Master's dissertation (2007)

Detailed reference viewed: 185 (31 ULg)