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See detailLes groupes d'entraide ou l'émergence de dynamiques citoyennes
Biquet, Véronique ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (2003), 39

L'article montre comment les groupes d'entraide peuvent constituer des lieux d'émergence de dynamiques citoyennes, en permettant qu'un pont soit crée entre l'espace privé des relations interpersonnelles ... [more ▼]

L'article montre comment les groupes d'entraide peuvent constituer des lieux d'émergence de dynamiques citoyennes, en permettant qu'un pont soit crée entre l'espace privé des relations interpersonnelles et l'espace public des questions relatives à la cité. [less ▲]

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See detailLa qualité différenciée
Burny, Philippe ULg

in Centre de Recherches agronomiques de Gembloux (CRA) (Ed.) 3ème journée Productions porcines et avicoles "Vers une politique de qualité, à quel prix ?", Gembloux, 8 octobre 2003 (2003)

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See detailDéveloppements récents en pychopédagogie et en linguistique appliquée pour la didactique des langues étrangères et secondes
Defays, Jean-Marc ULg

in Collès, Luc; Dufays, Jean-Louis; Maeder, C. (Eds.) Enseigner le français, l'espagnol et l'italien. Les langues romanes à l'heure des compétences (2003)

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See detailThe Mamluk Documents of the Venetian State Archives : Handlist
Bauden, Frédéric ULg

in Quaderni di Studi Arabi (2003), 20-21

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See detailShortened irradiation scheme, continuous infusion of 5-fluorouracil and fractionation of mitomycin C in locally advanced anal carcinomas. Results of a phase II study of the European Organization for Research and Treatment of Cancer. Radiotherapy and Gastrointestinal Cooperative Groups
Bosset, J. F.; Roelofsen, F.; Morgan, D. A. L. et al

in European Journal of Cancer (2003), 39

Abstract The European Organization for Research and Treatment of Cancer (EORTC) 22861 randomised trial established that combined radiochemotherapy is the standard treatment for locally advanced anal ... [more ▼]

Abstract The European Organization for Research and Treatment of Cancer (EORTC) 22861 randomised trial established that combined radiochemotherapy is the standard treatment for locally advanced anal cancer. This EORTC phase II study (#22953) tests the feasibility of reducing the gap between sequences to 2 weeks, to deliver Mitomycin C (MMC) in each radiotherapy sequence and 5-FU continuously during the treatment. The first sequence consisted of 36 Gy over 4 weeks. 5-FU 200 mg/m2/days 1–26, MMC 10 mg/m2/day 1 gap 16 days. Then a second sequence of 23.4 Gy over 17 days, 5-FU 200 mg/m2/days 1–17 and, MMC 10 mg/m2/day 1 was given. 43 patients with a World Health Organization (WHO) status of 0 (n=27) or 1 (n=16) and with T2-T4, N0-3 tumours were included. Compliance with the planned treatment, doses and duration was 93%. The complete response rate was 90.7%. Grade 3 toxicities of 28, 12 and 2% were observed for skin, diarrhoea and haematological toxicities, respectively. The 3-year estimated rates for trials 22861 and 22953 are: 68 and 88% for local control; 72 and 81% for colostomy-free interval, 62 and 84% for severe late toxicity-free interval, and 70 and 81% for survival, respectively. The 22953 scheme is feasible and the results are promising. This is now considered as the new standard scheme by the EORTC. [less ▲]

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See detailNucleation phenomenon in silica xerogels and Pd/SiO2, Ag/SiO2, Cu/SiO2 cogelled catalysts
Alié, Christelle ULg; Lambert, Stéphanie ULg; Heinrichs, Benoît ULg et al

in Journal of Sol-Gel Science and Technology (2003), 26(1-3), 827-830

Pd/SiO2, Ag/SiO2 and Cu/SiO2 xerogel catalysts have been synthesized by cogelation of tetraethoxysilane (TEOS) and chelates of Pd, Ag and Cu with 3-(2-aminoethylamino) propyltrimethoxysilane (EDAS). It ... [more ▼]

Pd/SiO2, Ag/SiO2 and Cu/SiO2 xerogel catalysts have been synthesized by cogelation of tetraethoxysilane (TEOS) and chelates of Pd, Ag and Cu with 3-(2-aminoethylamino) propyltrimethoxysilane (EDAS). It appears that, in cogelled samples, the metal complex acts as a nucleation agent in the formation of silica particles. The resulting catalysts are then composed of completely accessible metallic crystallites with a diameter of about 3 nm located inside silica porous particles with a monodisperse microporous distribution. Xerogels without metal synthesized with EDAS and TEOS (C. Alie, R. Pirard, A. J. Lecloux, and J.-P. Pirard, J. Non-Cryst. Solids 289, 88 (2001)) verify this hypothesis of nucleation by EDAS. [less ▲]

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See detailStrength imbalances in hamstring strains
Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg; Crielaard, Jean-Michel ULg

in Vlaams Tijdschrift voor Sport Geneeskunde en Sport Wetenschappen (2003), 95

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See detailResource partitioning in two heterochronic populations of Greek Alpine newts, Triturus alpestris veluchiensis
Denoël, Mathieu ULg; Schabetsberger, R.

in Acta Oecologica: International Journal of Ecology (2003), 24(1), 55-64

Current ecological models suggest that the maintenance of trophic polymorphisms is favoured by a different resource use in alternative morphs. Facultative paedomorphosis in newts is an example of ... [more ▼]

Current ecological models suggest that the maintenance of trophic polymorphisms is favoured by a different resource use in alternative morphs. Facultative paedomorphosis in newts is an example of phenotypic variation as paedomorphs retain morphological larval traits, such as gills and gill slits. The aim of this study was to find out whether heterochronic morphs occupy particular micro-habitats and focus on specific prey items. Resource partitioning was found between morphs. It concerns mainly food selection with paedomorphs preying more on plankton and less on terrestrial invertebrates than metamorphs. Some habitat specializations were also found with metamorphs being more abundant at the water surface than paedomorphs. Diel variation in habitat use of the two different morphs was minimal. Polymorphism allows Alpine newts to exploit the different resources in the lakes in order to minimize intraspecific competition, but the extent of resource partitioning depends on habitat characteristics. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved. [less ▲]

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See detailL'opération RESSAC : diagnostic métacognitif avant la période de 'bloque'
Leclercq, Dieudonné ULg; Detroz, Pascal ULg; Dupont, Chantal ULg et al

in Actes du 16ème colloque international de l'ADMEE-Europe, 4-6 septembre 2003 (2003)

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See detailProspective studyof CD4 and CD8 T-lynphocyte apoptosis as a marker for radiation induced late effects in 399 individual patients
Ozsahin; Crompton; Shi et al

in International Journal of Radiation, Oncology, Biology, Physics (2003), 55(2), 551-552

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See detailIdentification of type II and type III pyoverdine receptors from Pseudomonas aeruginosa.
de Chial, Magaly; Ghysels, Bart ULg; Beatson, Scott A. et al

in Microbiology (Reading, England) (2003), 149(Pt 4), 821-31

Pseudomonas aeruginosa produces, under conditions of iron limitation, a high-affinity siderophore, pyoverdine (PVD), which is recognized at the level of the outer membrane by a specific TonB-dependent ... [more ▼]

Pseudomonas aeruginosa produces, under conditions of iron limitation, a high-affinity siderophore, pyoverdine (PVD), which is recognized at the level of the outer membrane by a specific TonB-dependent receptor, FpvA. So far, for P. aeruginosa, three different PVDs, differing in their peptide chain, have been described (types I-III), but only the FpvA receptor for type I is known. Two PVD-producing P. aeruginosa strains, one type II and one type III, were mutagenized by a mini-TnphoA3 transposon. In each case, one mutant unable to grow in the presence of the strong iron chelator ethylenediaminedihydroxyphenylacetic acid (EDDHA) and the cognate PVD was selected. The first mutant, which had an insertion in the pvdE gene, upstream of fpvA, was unable to take up type II PVD and showed resistance to pyocin S3, which is known to use type II FpvA as receptor. The second mutant was unable to take up type III PVD and had the transposon insertion in fpvA. Cosmid libraries of the respective type II and type III PVD wild-type strains were constructed and screened for clones restoring the capacity to grow in the presence of PVD. From the respective complementing genomic fragments, type II and type III fpvA sequences were determined. When in trans, type II and type III fpvA restored PVD production, uptake, growth in the presence of EDDHA and, in the case of type II fpvA, pyocin S3 sensitivity. Complementation of fpvA mutants obtained by allelic exchange was achieved by the presence of cognate fpvA in trans. All three receptors posses an N-terminal extension of about 70 amino acids, similar to FecA of Escherichia coli, but only FpvAI has a TAT export sequence at its N-terminal end. [less ▲]

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See detailFracture prevention in postmenopausal women.
Bruyère, Olivier ULg; Edwards, John; Reginster, Jean-Yves ULg

in Clinical Evidence (2003), 9

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See detailNF-κB transcription factor induces drug resistance through MDR1 expression in cancer cells
Bentires-Alj, Mohamed; Barbu, Véronique; Fillet, Marianne ULg et al

in Oncogene (2003), 22

The ubiquitous NF-kappaB transcription factor has been reported to inhibit apoptosis and to induce drug resistance in cancer cells. Drug resistance is the major reason for cancer therapy failure and ... [more ▼]

The ubiquitous NF-kappaB transcription factor has been reported to inhibit apoptosis and to induce drug resistance in cancer cells. Drug resistance is the major reason for cancer therapy failure and neoplastic cells often develop multiple mechanisms of drug resistance during tumor progression. We observed that NF-kappaB or P-glycoprotein inhibition in the HCT15 colon cancer cells led to increased apoptotic cell death in response to daunomycin treatment. Interestingly, NF-kappaB inhibition through transfection of a plasmid coding for a mutated IkappaB-alpha inhibitor increased daunomycin cell uptake. Indeed, the inhibition of NF-kappaB reduced mdr1 mRNA and P-glycoprotein expression in HCT15 cells. We identified a consensus NF-kappaB binding site in the first intron of the human mdr1 gene and demonstrated that NF-kappaB complexes could bind with this intronic site. Moreover, NF-kappaB transactivates an mdr1 promoter luciferase construct. Our data thus demonstrate a role for NF-kappaB in the regulation of the mdr1 gene expression in cancer cells and in drug resistance. [less ▲]

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See detailChlamydomonas reinhardtii as a eukaryotic photosynthetic model for studies of heavy metal homeostasis and tolerance
Hanikenne, Marc ULg

in New Phytologist (2003), 159(2), 331-340

The green alga Chlamydomonas reinhardtii is a useful model of a photosynthetic cell. This unicellular eukaryote has been intensively used for studies of a number of physiological processes such as ... [more ▼]

The green alga Chlamydomonas reinhardtii is a useful model of a photosynthetic cell. This unicellular eukaryote has been intensively used for studies of a number of physiological processes such as photosynthesis, respiration, nitrogen assimilation, flagella motility and basal body function. Its easy-to-manipulate and short life cycle make this organism a powerful tool for genetic analysis. Over the past 15 yr, a dramatically increased number of molecular technologies (including nuclear and organellar transformation systems, cosmid, yeast artificial chromosome (YAC) and bacterial artificial chromosome (BAC) libraries, reporter genes, RNA interference, DNA microarrays, etc.) have been applied to Chlamydomonas . Moreover, as parts of the Chlamydomonas genome project, molecular mapping, as well as whole genome and extended expressed sequence tag (EST) sequencing programs, are currently underway. These developments have allowed Chlamydomonas to become an extremely valuable model for molecular approaches to heavy metal homeostasis and tolerance in photosynthetic organisms. [less ▲]

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See detailAge, sex, and weight at weaning influence organ weight and gastrointestinal development of weanling pigs
Pluske, J. R.; Kerton, D. J.; Cranwell, P. D. et al

in Australian Journal of Agricultural Research (2003), 54(5), 515-527

The present study was designed to determine the interrelationships between sex, weaning age, and weaning weight on aspects of physiological and gastrointestinal development in pigs. Forty-eight Large ... [more ▼]

The present study was designed to determine the interrelationships between sex, weaning age, and weaning weight on aspects of physiological and gastrointestinal development in pigs. Forty-eight Large White x Landrace pigs were used in a factorial arrangement with the respective factors being: age at weaning ( 14 or 28 days), weight at weaning ( heavy or light), sex ( boar or gilt), and time after weaning ( 1, 7, and 14 days). At weaning, 48 pigs were removed from the sow; 16 pigs were then fasted for 24 h before euthanasia for determination of organ weights, gut histology, and enzymology, and 32 pigs were offered a high quality pelleted weaner diet ad libitum for subsequent assessment of organ weights, histology, and enzymology at 7 and 14 days after weaning. On Day 6 and 13 after weaning, 2 pigs from each group had their feed removed, and 24 h later were euthanased and similar measurements were taken. In general, the data highlighted the overall gastrointestinal underdevelopment of pigs weaned at 2 weeks of age and of pigs weaned light-for-age at either 2 or 4 weeks. Heavier body organs, gastrointestinal organs, and accessory digestive organs observed after weaning, except for the spleen, presumably reflected the increase in substrates available for cellular growth as feed intake increased after weaning, and the development of organs required to process this feed. Interestingly, the relative weights (% of liveweight) of the stomach and small intestine and, to a lesser extent, the caecum and colon, were greater in the light, 14-day-old weaned pigs, but these differences diminished with increasing time after weaning. Consistent effects due to age, weight, and sex were not observed for villous height and crypt depth, or for the specific activities of the brush-border and pancreatic enzymes measured. However, increases (P < 0.001) in the activities of maltase (P < 0.001), glucoamylase ( P < 0.001), and sucrase (P = 0.020) ( all expressed per gram of mucosa), and that of trypsin ( per gram of pancreas), occurred by 14 days after weaning. This most likely reflected the inducible nature of these enzymes in response to the increasing intake of substrates provided in the diet. In contrast, the specific activity of lactase declined (P = 0.012) in the first 14 days after weaning. These data suggest that pigs weaned at 2 weeks of age and pigs weaned light-for-age at either 2 or 4 weeks have a less developed gastrointestinal tract, and that its development after weaning might proceed differently to that of pigs weaned older and heavier. [less ▲]

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See detailAmphiphilic copolymers of epsilon-caprolactone and gamma-substituted epsilon-caprolactone. Synthesis and functionalization of poly(D,L-lactide) nanoparticles
Gautier, Sandrine; D'Aloia, Violetta; Halleux, Olivier et al

in Journal of Biomaterials Science. Polymer Edition (2003), 14(1), 63-85

Fully biodegradable and surface-functionalized poly(D,L-lactide) (PLA) nanoparticles have been prepared by a co-precipitation technique. Novel amphiphilic random copolyesters P(CL-co-gamma XCL) were ... [more ▼]

Fully biodegradable and surface-functionalized poly(D,L-lactide) (PLA) nanoparticles have been prepared by a co-precipitation technique. Novel amphiphilic random copolyesters P(CL-co-gamma XCL) were synthesized by controlled copolymerization of epsilon-caprolactone and epsilon-caprolactone substituted in the gamma-position by a hydrophilic X group, where X is either a cationic pyridinium (gamma-Py-CL) or a non-ionic hydroxyl (gamma-OH-CL). Nanoparticles were prepared by co-precipitation of PLA with the P(CL-co-gamma-XCL) copolyester from a DMSO solution. Small amounts of cationic P(CL-co-gamma-Py-CL) copolymers are needed to quantitatively form stable nanoparticles (ca. 10 mg/100 mg PLA), although larger amounts of non-ionic P(CL-co-gamma-OH-CL) copolymers are needed (ges12.5 mg/100 mg PLA). Copolymers with a low degree of polymerization (ca. 40) are more efficient stabilizers, probably because of faster migration towards the nanoparticle-water interface. The nanoparticle diameter decreases with the polymer concentration in DMSO, e.g. from ca. 160 nm (16 mg/ml) to ca. 100 nm (2 mg/ml) for PLA/P(CL-co-gamma-Py-CL) nanoparticles. Migration of the P(CL-co-gamma-XCL) copolyesters to the nanoparticle surface was confirmed by measurement of the zeta potential, i.e. ca. +65 mV for P(CL-co-gamma-Py-CL) and -7 mV for P(CL-co-gamma-OH-CL). The polyamphiphilic copolyesters stabilize PLA nanoparticles by electrostatic or steric repulsions, depending on whether they are charged or not. They also impart functionality and reactivity to the surface, which opens up new opportunities for labelling and targeting purposes. [less ▲]

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See detailAnalyses psychométriques des questions des 10 check-up MOHICAN : vue d'ensemble
Leclercq, Dieudonné ULg; Gilles, Jean-Luc ULg

in Leclercq, Dieudonné (Ed.) Diagnostic cognitif et métacognitif au seuil de l'université : le projet MOHICAN mené par les 9 universités de la Communauté française Wallonie-Bruxelles (2003)

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