Publications ORBi OA
Bookmark and Share    
Full Text
See detailAdaptive λ-tracking for Systems with Higher Relative Degree
Bullinger, Eric ULg

Doctoral thesis (2000)

Detailed reference viewed: 21 (1 ULg)
Full Text
Peer Reviewed
See detailTraitement de la maladie de Crohn de l'adulte par anticorps anti-tumor necrosis factor-alpha (TNF alpha)
Belaiche, Jacques ULg; Louis, Edouard ULg

in Revue Médicale de Liège (2000), 55(9), 827-32

Crohn's disease (CD) is a chronic inflammatory disease of the bowel characterized by segmental transmural inflammation and granulomatous changes. TNF alpha is a member of a large family of proteins and ... [more ▼]

Crohn's disease (CD) is a chronic inflammatory disease of the bowel characterized by segmental transmural inflammation and granulomatous changes. TNF alpha is a member of a large family of proteins and receptors that are involved in immune regulation. It is a proinflammatory and immunoregulatory cytokine synthesized by monocytes, macrophages, and T cells. TNF alpha plays an early central role in the cytokine cascade of the inflammatory process. Recently, chimeric monoclonal antibodies that inhibits TNF alpha have been used in the treatment of Crohn's disease. Infliximab has been the most largely used antibody. It is commercialized in the USA and has recently obtained an European marketing approvement. Infliximab is indicated for the treatment of moderately to severely active CD in patients having an inadequate response to conventional therapy. Clinical trials have demonstrated efficacy when the agent is initiated as a 5 mg/kg single intravenous infusion. In patients with fistulizing CD, administration of 2 subsequent 5 mg/kg doses 2 and 6 weeks after the initial dose appears to be efficacious. Limited clinical data also suggest that infliximab retreatment regimen restores response and maintains remission rates. Infliximab appears to be well tolerated. To date, very little is known about the potential for long-term toxicity with infliximab therapy. [less ▲]

Detailed reference viewed: 106 (1 ULg)
Full Text
Peer Reviewed
See detailTernary polymer blend with core-shell dispersed phases: effect of the core-forming polymer on phase morphology and mechanical properties
Luzinov, Igor; Pagnoulle, Christophe; Jérôme, Robert ULg

in Polymer (2000), 41(19), 7099-7109

Phase morphology and mechanical properties of ternary blends consisting of PS (polystyrene), SBR (styrene butadiene rubber) and different polyolefins (POs) have been studied. PS, systematically forms the ... [more ▼]

Phase morphology and mechanical properties of ternary blends consisting of PS (polystyrene), SBR (styrene butadiene rubber) and different polyolefins (POs) have been studied. PS, systematically forms the matrix, SBR and PO being combined in the dispersed phase. Although POs of various melt viscosity and stiffness are used, the binary (SBR/PO) dispersed phase is of a core-shell structure, in which PO forms the core. Upon increasing the viscosity of PO, the average size of the cores and the SBR domains including them increases. Comparison of the experimental shear storage modulus of the blends with theoretical predictions indicates that the stress transfer from the PS matrix to the PO core through the SBR shell depends on the modulus of the SBR envelope. The ultimate mechanical properties of the ternary blends are sensitive to the stiffness of the PO core. [less ▲]

Detailed reference viewed: 75 (16 ULg)
Full Text
Peer Reviewed
See detailAn agent-inspired active network resource trading model applied to congestion control
Yamamoto, Lidia; Leduc, Guy ULg

in Lecture Notes in Computer Science (2000, September), 1931

In order to accommodate fluctuations in network conditions, adaptive applications need to obtain information about resource availability, Using active networks, new models for adaptive applications can be ... [more ▼]

In order to accommodate fluctuations in network conditions, adaptive applications need to obtain information about resource availability, Using active networks, new models for adaptive applications can be envisaged, which can benefit from the possibility to send mobile code to the network nodes. We describe a model for trading resources inside an active net-work node, based on the interaction between capsules as reactive user agents, and resource manager agents which reside in the network nodes. We apply the model to the case of a many-to-one audio application with congestion control, which trades off link resources against memory when there is congestion at the outgoing interface towards the destination. Our simulation results indicate that the application makes effective use of the available resources, and it also allows resources to be shared according to user preferences. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailCombined Suicide and Cytokine Gene Therapy for Peritoneal Carcinomatosis
Lechanteur, Chantal ULg; Delvenne, Philippe ULg; Princen, Frédéric et al

in Gut (2000), 47(3), 343-8

BACKGROUND: Gene therapy is a novel approach for the treatment of cancers, and tumours disseminated in the peritoneal cavity are suitable for in situ delivery of a therapeutic gene. AIMS: The efficacy of ... [more ▼]

BACKGROUND: Gene therapy is a novel approach for the treatment of cancers, and tumours disseminated in the peritoneal cavity are suitable for in situ delivery of a therapeutic gene. AIMS: The efficacy of a therapy combining a suicide gene (herpes simplex virus type I thymidine kinase (HSV-TK)) and cytokine genes was investigated in a model of peritoneal carcinomatosis induced by colon carcinoma cells in syngeneic rats. MATERIAL AND METHODS: Pre-established macroscopic tumours in BDIX rats were treated by intraperitoneal injections of retrovirus producing cells (FLYA13 TK, FLYA13 granulocyte macrophage-colony stimulating factor (GM-CSF), FLYA13 interleukin 12 (IL-12)) and ganciclovir (GCV). RESULTS: TK/GCV treated animals showed a slight increase in survival time (72 days) compared with the control group (63 days) while the association of cytokine and TK/GCV gene therapy resulted in significantly improved survival, with a large proportion of animals remaining tumour free on day 480 (60% and 40% for TK/GCV/GM-CSF and TK/GCV/IL-12 treated animals, respectively). Histological analysis of treated animals showed that the remaining tumour nodes were infiltrated by mononuclear cells but no major differences were observed between the various treatments. Immunohistochemical analysis revealed that lymphoid CD4(+) and CD8(+) T cells as well as macrophages accumulated outside untreated tumour nodes while CD8(+) and CD25(+) activated T cells and macrophages heavily infiltrated the tumours after the different treatments. CONCLUSIONS: Our data indicate that combined suicide and cytokine gene therapy is a powerful approach for the treatment of macroscopic peritoneal carcinomatosis. [less ▲]

Detailed reference viewed: 27 (4 ULg)
Full Text
See detailLes aéroports wallons
Thiry, Bernard ULg; Charlier, J.; Delepiere, Ch. et al

Report (2000)

Detailed reference viewed: 22 (4 ULg)
Full Text
See detailTransport ferroviaire à grande vitesse - Les passagers
Gathon, Henry-Jean ULg; Thiry, Bernard ULg; Charlier, J. et al

Report (2000)

Detailed reference viewed: 34 (7 ULg)
Full Text
See detailLa gestion environnementale des aéroports
Charlier, J.; Delepiere, Ch.; Marchal, Jean ULg et al

Report (2000)

Detailed reference viewed: 32 (4 ULg)
Full Text
See detailL'écriture en chantier
Baye, Ariane ULg; Denooz, Régine

Learning material (2000)

Detailed reference viewed: 22 (3 ULg)
Full Text
See detailL'Université au fil du temps. Fin de l'épopée Ulg.
Frankignoulle, Pierre ULg

Article for general public (2000)

Detailed reference viewed: 14 (3 ULg)
Full Text
Peer Reviewed
See detailLeptin Effects on Pulsatile Gonadotropin Releasing Hormone Secretion from the Adult Rat Hypothalamus and Interaction with Cocaine and Amphetamine Regulated Transcript Peptide and Neuropeptide Y
Parent, Anne-Simone ULg; Lebrethon, M. C.; Gerard, Arlette ULg et al

in Regulatory Peptides (2000), 92(1-3), 17-24

Leptin may act as a negative feedback signal to the hypothalamic control of appetite through suppression of neuropeptide Y (NPY) secretion and stimulation of cocaine and amphetamine regulated transcript ... [more ▼]

Leptin may act as a negative feedback signal to the hypothalamic control of appetite through suppression of neuropeptide Y (NPY) secretion and stimulation of cocaine and amphetamine regulated transcript (CART). We aimed at studying the effects of leptin, CART and NPY on the hypothalamic control of the pituitary-gonadal system. Pulsatile gonadotropin-releasing hormone (GnRH) secretion was studied in vitro using retrochiasmatic hypothalamic explants from adult rats. In the female, GnRH pulse amplitude was significantly increased by leptin (10(-7) M) and CART (10(-6) M) irrespective of the estrus cycle phase while no such effects were seen in the male. The GnRH interpulse interval was not affected in both sexes. Passive immunoneutralization against CART caused a reduction in GnRH pulse amplitude in the female. A slight but significant increase in GnRH pulse amplitude was caused by NPY (10(-7) M) in the female. However, GnRH pulse amplitude was not affected by a Y5-receptor antagonist (10(-6) M) while the interpulse interval was significantly increased as shown previously in the male. The increase in GnRH pulse amplitude caused by leptin was totally prevented by coincubation with an anti-CART antiserum whereas it was not affected by coincubation with the NPY Y5-receptor antagonist (10(-7) M). In conclusion, leptin and NPY show separate permissive effects on GnRH secretion in the adult rat hypothalamus. In both sexes, NPY is prominently involved in the control of the frequency of pulsatile GnRH secretion through the Y5 receptor subtype. Leptin causes a female-specific facilitatory effect on GnRH pulse amplitude which is mediated by CART and which occurs irrespective of the estrus cycle phase. [less ▲]

Detailed reference viewed: 23 (1 ULg)
Full Text
See detailSynthesis of new hydrophilic γ-substituted poly-ε-caprolactones
Lecomte, Philippe ULg; D'aloia, Violetta; Mazza, Michaël et al

Conference (2000, August 20)

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailSimulations of observations with the Optical Monitor of the X-ray Multi-Mirror Satellite
Royer, P.; Manfroid, Jean ULg; Gosset, Eric ULg et al

in Astronomy and Astrophysics. Supplement Series (2000), 145

This paper addresses the question of the observations to be performed with the Optical Monitor (OM) of the X-ray Multi-Mirror Satellite (XMM) under several aspects. First, we discuss XMM-OM's photometric ... [more ▼]

This paper addresses the question of the observations to be performed with the Optical Monitor (OM) of the X-ray Multi-Mirror Satellite (XMM) under several aspects. First, we discuss XMM-OM's photometric system and its colour transformations towards the standard U BV system. Second, we establish a set of procedures to determine the temperature and the amount of interstellar absorption affecting the observed stars. Last, we address the possibility of isolating quasars in multidimensional colour diagrams based on the XMM-OM filter set. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailExploring the gravitationally lensed system HE 1104-1805: near-IR spectroscopy
Courbin, F.; Lidman, C.; Meylan, G. et al

in Astronomy and Astrophysics (2000), 360

A new technique for the spatial deconvolution of spectra is applied to near-IR (0.95-2.50 mum) NTT/SOFI spectra of the lensed, radio-quiet quasar HE 1104-1805. The continuum of the lensing galaxy is ... [more ▼]

A new technique for the spatial deconvolution of spectra is applied to near-IR (0.95-2.50 mum) NTT/SOFI spectra of the lensed, radio-quiet quasar HE 1104-1805. The continuum of the lensing galaxy is revealed between 1.5 mum and 2.5 mum. Although the spectrum does not show strong emission features, it is used in combination with previous optical and IR photometry to infer a plausible redshift in the range 0.8 < z < 1.2. Modeling of the system shows that the lens is complex, probably composed of the red galaxy seen between the quasar images and a more extended component associated with a galaxy cluster with fairly low velocity dispersion (~ 575 km s[SUP]-1[/SUP]). Unless more constrains can be put on the mass distribution of the cluster, e.g. from deep X-ray observations, HE 1104-1805 will not be a good system to determine H[SUB]0[/SUB]. We stress that multiply imaged quasars with known time delays may prove more useful as tools for detecting dark mass in distant lenses than for determining cosmological parameters. The spectra of the two lensed images of the source are of great interest. They show no trace of reddening at the redshift of the lens nor at the redshift of the source. This supports the hypothesis of an elliptical lens. Additionally, the difference between the spectrum of the brightest component and that of a scaled version of the faintest component is a featureless continuum. Broad and narrow emission lines, including the FeII features, are perfectly subtracted. The very good quality of our spectrum makes it possible to fit precisely the optical Fe II feature, taking into account the underlying continuum over a wide wavelength range. HE 1104-1805 can be classified as a weak Fe II emitter. Finally, the slope of the continuum in the brightest image is steeper than the continuum in the faintest image and supports the finding by Wisotzki et al. (1993) that the brightest image is microlensed. This is particularly interesting in view of the new source reconstruction methods from multiwavelength photometric monitoring. While HE 1104- 1805 does not seem the best target for determining cosmological parameters, it is probably the second most interesting object after Q 2237+0305 (the Einstein cross), in terms of microlensing. Based on observations collected with the ESO New Technology Telescope (program 61.B-0413) [less ▲]

Detailed reference viewed: 11 (3 ULg)
Full Text
Peer Reviewed
See detailDosage de l'hémoglobine A1C et hémoglobinopathies : problèmes posés et conduite à tenir
Gillery, Pierre; Hue, G.; Bordas-Fonfrède, M. et al

in Annales de Biologie Clinique (2000), 58(4), 425-9

La valeur sémiologique de l'hémoglobine A1c (HbA1c) en tant que marqueur rétrospectif cumulatif de l'équilibre glycémique chez le patient diabétique est prise en défaut en cas d'hémoglobinopathie. La ... [more ▼]

La valeur sémiologique de l'hémoglobine A1c (HbA1c) en tant que marqueur rétrospectif cumulatif de l'équilibre glycémique chez le patient diabétique est prise en défaut en cas d'hémoglobinopathie. La présence d'une hémoglobine anormale engendre des problèmes méthodologiques en raison des interférences provoquées dans la plupart des dosages, mais surtout perturbe le processus normal de glycation de l'HbA en HbA1c, et provoque souvent un certain degré d'hémolyse, très variable et impossible à quantifier. Cet article passe en revue les problèmes méthodologiques et sémiologiques relatifs à la présence de formes anormales de l'hémoglobine et propose une conduite à tenir standardisée en cas d'hémoglobinopathie. [less ▲]

Detailed reference viewed: 223 (1 ULg)
Full Text
Peer Reviewed
See detailThe Frequency of Plasmodesmata Increases Early in the Whole Shoot Apical Meristem of Sinapis Alba L. During Floral Transition
Ormenese, Sandra ULg; Havelange, Andrée ULg; Deltour, Roger ULg et al

in Planta (2000), 211(3), 370-5

The frequency of plasmodesmata increases in the shoot apical meristem of plants of Sinapis alba L. induced to flower by exposure to a single long day. This increase is observed within all cell layers (L1 ... [more ▼]

The frequency of plasmodesmata increases in the shoot apical meristem of plants of Sinapis alba L. induced to flower by exposure to a single long day. This increase is observed within all cell layers (L1, L2, L3) as well as at the interfaces between these layers, and it occurs in both the central and peripheral zones of the shoot apical meristem. The extra plasmodesmata are formed only transiently, from 28 to 48 h after the start of the long day, and acropetally since they are detectable in L3 4 h before they are seen in L1 and L2. These observations indicate that (i) in the Sinapis shoot apical meristem at floral transition, there is an unfolding of a single field with increased plasmodesmatal connectivity, and (ii) this event is an early effect of the arrival at this meristem of the floral stimulus of leaf origin. Since (i) the wave of increased frequency of plasmodesmata is 12 h later than the wave of increased mitotic frequency (A. Jacqmard et al. 1998, Plant cell proliferation and its regulation in growth and development, pp. 67 78; Wiley), and (ii) the increase in frequency of plasmodesmata is observed in all cell walls, including in walls not deriving from recent divisions (periclinal walls separating the cell layers), it is concluded that the extra plasmodesmata seen at floral transition do not arise in the forming cell plate during mitosis and are thus of secondary origin. [less ▲]

Detailed reference viewed: 23 (1 ULg)
Full Text
Peer Reviewed
See detailStriatum forever, despite sequence learning variability : A random effect analysis of PET data
Peigneux, Philippe ULg; Maquet, Pierre ULg; Meulemans, Thierry ULg et al

in Human Brain Mapping (2000), 10(4), 179-194

This PET study is concerned with the what, where, and how of implicit sequence learning. In contrast with previous studies imaging the serial reaction time (SRT) task, the sequence of successive locations ... [more ▼]

This PET study is concerned with the what, where, and how of implicit sequence learning. In contrast with previous studies imaging the serial reaction time (SRT) task, the sequence of successive locations was determined by a probabilistic finite-state grammar. The implicit acquisition of statistical relationships between serially ordered elements (i.e., what) was studied scan by scan, aiming to evidence the brain areas (i.e., where) specifically involved in the implicit processing of this core component of sequential higher-order knowledge. As behavioural results demonstrate between- and within-subjects variability in the implicit acquisition of sequential knowledge through practice, functional PET data were modelled using a random-effect model analysis (i.e., how) to account for both sources of behavioural variability. First, two mean condition images were created per subject depending on the presence or not of implicit sequential knowledge at the time of each of the 12 scans. Next, direct comparison of these mean condition images provided the brain areas involved in sequential knowledge processing. Using this approach, we have shown that the striatum is involved in more than simple pairwise associations and that it has the capacity to process higher-order knowledge. We suggest that the striatum is not only involved in the implicit automatization of serial information through prefrontal cortex-caudate nucleus networks, but also that it plays a significant role for the selection of the most appropriate responses in the context created by both the current and previous stimuli, thus contributing to better efficiency and faster response preparation in the SRT task. Hum. Brain Mapping 10:179-194, 2000. © 2000 Wiley-Liss, Inc. [less ▲]

Detailed reference viewed: 4 (1 ULg)
Full Text
Peer Reviewed
See detailApplication of the Stiffened Plate Method in Optimizing Hydraulic Structures
Rigo, Philippe ULg; NGuyen, Nhy jhuynh

in International Colloquium in Mechanics of Solids, Fluids, Structures and Interactions (2000, August)

Detailed reference viewed: 23 (2 ULg)