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See detailTopical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo.
Humbert, Philippe G; Haftek, Marek; Creidi, Pierre et al

in Experimental Dermatology (2003), 12(3), 237-44

Vitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this ... [more ▼]

Vitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this molecule as a potential candidate for use in the prevention and treatment of skin ageing. A topically applied cream containing 5% vitamin C and its excipient were tested on healthy female volunteers presenting with photoaged skin on their low-neck and arms in view to evaluate efficacy and safety of such treatment. A double-blind, randomized trial was performed over a 6-month period, comparing the action of the vitamin C cream vs. excipient on photoaged skin. Clinical assessments included evaluation at the beginning and after 3 and 6 months of daily treatment. They were performed by the investigator and compared with the volunteer self assessment. Skin relief parameters were determined on silicone rubber replicas performed at the same time-points. Cutaneous biopsies were obtained at the end of the trial and investigated using immunohistochemistry and electron microscopy. Clinical examination by a dermatologist as well as self-assessment by the volunteers disclosed a significant improvement, in terms of the 'global score', on the vitamin C-treated side compared with the control. A highly significant increase in the density of skin microrelief and a decrease of the deep furrows were demonstrated. Ultrastructural evidence of the elastic tissue repair was also obtained and well corroborated the favorable results of the clinical and skin surface examinations. Topical application of 5% vitamin C cream was an effective and well-tolerated treatment. It led to a clinically apparent improvement of the photodamaged skin and induced modifications of skin relief and ultrastructure, suggesting a positive influence of topical vitamin C on parameters characteristic for sun-induced skin ageing. [less ▲]

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See detailEcoFerme: un logiciel d'évaluation environnementale de l'exploitation agricole
Debouche, Charles ULg

in Les Nouvelles de l'été (2003), (3e trimetre), 14-15

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See detailLes surcoûts de la désurbanisation
Dubois, Olivier; Halleux, Jean-Marie ULg

in A+ (2003), (Février-Mars), 34-37

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See detailLa didactique de la géographie, Cent ans de géographie à l’Université de Liège, 1903-2003
Merenne-Schoumaker, Bernadette ULg

in Bulletin de la Société Géographique de Liège (2003), 43

100 years of training and research in didactics of geography at the University of Liege

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See detailCent ans de Didactique de la Géographie à l’Université de Liège
Merenne-Schoumaker, Bernadette ULg

in Puzzle (2003), (14), 14-16

One hundred years of training and research in didactics of geography at the University of Liege

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See detailDe la géographie des professeurs à la géographie de l’action : une place nouvelle dans l’enseignement secondaire
Merenne-Schoumaker, Bernadette ULg

in Belgeo (2003), 2003(2), 157-164

Within 50 years, school geography changed drastically, especially in the secondary schools of French-speaking Belgium. This evolution, made of four major phases, is related with the changes of both ... [more ▼]

Within 50 years, school geography changed drastically, especially in the secondary schools of French-speaking Belgium. This evolution, made of four major phases, is related with the changes of both, societies and values. Although school geography is not any more a “reduction” of academic geography, its evolution is also related with the changes that took place within universities. On the basis of a SWOT analysis, forces and weaknesses of this secondary school geography are underlined and some action proposals are suggested. [less ▲]

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See detailLa géographie économique, Cent ans de géographie à l’Université de Liège, 1903-2003
Merenne-Schoumaker, Bernadette ULg

in Bulletin de la Société Géographique de Liège (2003), (43), 111-119

100 years of economic geography at the University of Liege

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See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULg; de Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Annales de Médecine Vétérinaire (2003), 147

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently ... [more ▼]

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently anticholinergic drugs are potentially able to improve the pulmonary function of horses in acute crisis. Among these, atropine and ipratropium bromide have been previously experimented and their beneficial effects reported. In the present work, glycopyrrolate, another synthetic anticholinergic molecule has been tested for bronchodilator efficiency in heaves-affected horses. An acute exacerbation of the illness was obtained by a natural challenge with hay and straw in 7 heaves-affected horses. The first day, the reversibility of the bronchospasm of these horses was controlled by intravenous administration of atropine. Then, pulmonary function tests including mechanics of breathing, ie measurement of pleural pressure changes and respiratory airflows, and arterial blond gases analysis, were performed before as well as 15 and 60 minutes alter inhalation of 1500 µg of glycopyrrolate (Robinul®). The crisis induced a dramatic increase of total pulmonary resistance and maximal pleural pressure changes as well as a decrease in dynamic lung compliance. These changes were significantly reversed 15 and 60 minutes after inhalation of glycopyrrolate. We did not observe any adverse effects similar to those classically observed with atropine. These results showed that glycopyrrolate is a very efficient bronchodilator that may be used by the practitioner to treat a heaves-affected horses in crisis [less ▲]

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See detailProduction de l'urbanisation et infrastructures de viabilisation
Halleux, Jean-Marie ULg; Lambotte, Jean-Marc ULg; Bruck, L. et al

in Ruimte & Planning (2003), (3), 197-210

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See detailLe Musée en Piconrue de Bastogne
Donneau, Olivier ULg

in Invitation au musée : Courrier du patrimoine culturel de la Communauté française (2003), 4

Courte présentation des activités du Musée en Piconrue de Bastogne.

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See detailPreliminary observation of sperm storage in Adalia bipunctata (Coleoptera: Coccinellidae) : sperm size and number
Arnaud, Ludovic; Spinneux, Yves; Haubruge, Eric ULg

in Applied Entomology and Zoology (2003), 38

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See detailEvaluation formative - Définition, justifications théoriques et illustrations
Poumay, Marianne ULg

Learning material (2003)

Ce document propose quelques mises au point sur l'évaluation formative puis une grille d'analyse des facettes de cette évaluation formative, issue des travaux de Dieudonné Leclercq. Cette grille ... [more ▼]

Ce document propose quelques mises au point sur l'évaluation formative puis une grille d'analyse des facettes de cette évaluation formative, issue des travaux de Dieudonné Leclercq. Cette grille, simplifiée, est ensuite appliquée pour décrire des cours en ligne. L'article se termine par une section de "FAQ", avant la section bibliographique. [less ▲]

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See detailCompte rendu de Reliques et châsses de la collégiale de Soignies
George, Philippe ULg

in Revue d'Histoire Ecclésiastique (2003)

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See detailProvider continuity in family medicine: does it make a difference for total health care costs?
De Maeseneer, Jan M; De Prins, Lutgarde; Gosset, Christiane ULg et al

in Annals of Family Medicine (2003), 1(3), 144-8

BACKGROUND: International comparisons of health care systems have shown a relationship at the macro level between a well-structured primary health care plan and lower total health care costs. The ... [more ▼]

BACKGROUND: International comparisons of health care systems have shown a relationship at the macro level between a well-structured primary health care plan and lower total health care costs. The objective of this study was to assess whether provider continuity with a family physician is related to lower health care costs using the individual patient as the unit of analysis. METHODS: We undertook a study of a stratified sample of patients (age, sex, region, insurance company) for which 2 cohorts were constructed based on the patients' utilization pattern of family medicine (provider continuity or not). Patient utilization patterns were observed for 2 years. The setting was the Belgian health care system. The participants were 4,134 members of the 2 largest health insurance companies in 2 regions (Aalst and Liege). The main outcome measures were the total health care costs of patients with and without provider continuity with a family physician, controlling for variables known to influence health care utilization (need factors, predisposing factors, enabling factors). RESULTS: Bivariate analyses showed that patients who were visiting the same family physician had a lower total cost for medical care. A multivariate linear regression showed that provider continuity with a family physician was one of the most important explanatory variables related to the total health care cost. CONCLUSIONS: Provider continuity with a family physician is related to lower total health care costs. This finding brings evidence to the debate on the importance of structured primary health care (with high continuity for family practice) for a cost-effective health policy. [less ▲]

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See detailEstrogens reduce the expression of YKL-40 in the retina: Implications for eye and joint diseases
Rakic, Jean-Marie ULg; Lambert, Vincent ULg; Deprez, Manuel ULg et al

in Investigative Ophthalmology & Visual Science (2003), 44(4), 1740-1746

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially ... [more ▼]

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially expressed genes that could be relevant to the natural history of human age-related macular degeneration (AMD). METHODS. Chorioretinal tissues from two groups of 25 treated and untreated OVX mice were analyzed by using cDNA array technology. The expression level of selected genes was confirmed in triplicate by RT-PCR and related to the estrogenic status of the animals. Expression of the YKL-40 gene was further investigated in intact or diseased human retinas and in a murine model of experimental choroidal neovascularization (CNV), using laser pressure catapulting. RESULTS. Of the approximately, 10,000 genes screened, only YKL-40 expression was significantly downregulated by 17-beta-estradiol. YKL-40 was expressed in intact human neural retina and in the RPE. The expression of YKL-40 was upregulated in experimental CNV and in neovascular membranes extracted from patients affected by the exudative form of AMD. CONCLUSIONS. These observations indicate that YKL-40 expression in the retina is modulated by serum levels of estradiol. This protein could be relevant to the development of AMD and is also a new mediator to take into account when evaluating the broad consequences of hormonal replacement therapy. [less ▲]

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See detailEspace construit
Frankignoulle, Pierre ULg

in Lask, Tomke (Ed.) Constructions sociales de l'espace. Les territoires de l'anthropologie de la communication. (2003)

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See detailInsectes et communication
Arnaud, Ludovic; Detrain, Claire; Gaspar, Charles et al

in Journal des Ingénieurs (Le) (2003), 87

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See detailContre l'ankylose de l'imagination
Frankignoulle, Pierre ULg; Bianchi, Michael

in A+ (2003), 181

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See detailBiomarquers d’exposition en milieu terrestre : impact d’hydrocarbures halogénés sur l’activité de trois systèmes enzymatiques chez Drosophila pseudoobscura
Dannau, Marie; Amichot, Marcel; Leenaers, Lionel et al

in Environnement Risques & Santé (2003), 2

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