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See detailShoulder isokinetic profile after Latarjet's technique
Forthomme, Bénédicte ULg; Willems, Serge; Hurlet, Sandrine ULg et al

in Isokinetics & Exercise Science (2005), 13(1), 71-76

The following procedures were performed on 23 patients (15 of them males): a shoulder strength isokinetic evaluation of the internal (IR) and external (ER) rotators (with the shoulder 45 degrees and 90 ... [more ▼]

The following procedures were performed on 23 patients (15 of them males): a shoulder strength isokinetic evaluation of the internal (IR) and external (ER) rotators (with the shoulder 45 degrees and 90 degrees abducted in the frontal plane), a passive range of motion measurement, a Rowe score and a scanner exam. These patients had previously undergone open coracoid transposition using Latarjet's technique according to two different surgical procedures: a tenotomy (n = 6) or a splitting (n = 17) of the subscapularis muscle approach. In our retrospective study, the period of time between surgery and assessment was an average of 30 months. The average Rowe score was 89 on a scale of 100, with a good pattern of passive mobility. The isokinetic data showed an external rotator weakness (in all testing conditions), most notably at 60 degrees/s in 45 degrees of abduction position (p < 0.001 - 12.2%). By contrast, the internal rotators were only significantly (p < 0.05) impaired (8.2%) at 60 degrees/s in the 90 degrees of abduction position. Consequently, the external/internal rotator ratio (ERAR) was reduced in the 45 degrees of abduction installation only, highlighting the influence of testing position on the isokinetic results and therefore on the shoulder muscle profile. Surgical technique comparison revealed that only the tenotomy procedure entailed an IR deficit (17%) measured at 45 degrees of abduction installation. Shoulders (n = 5) presenting a fatty degeneration of the subscapularis muscle >= stage II (corresponding exclusively to the tenotomy surgical approach) showed an internal rotator weakness (19%) measured in 45 degrees of abduction. Patients (n = 13) without subscapularis fatty degradation (corresponding solely to the horizontal splitting approach) did not develop any impairment of strength in internal rotators. Furthermore, no correlation between mobility pattern and strength impairment was observed in the study. [less ▲]

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See detailRepeated beta irradiation for recurrent coronary in-stent restenosis.
Eeckhout, E; Roguelov, C; Berger, A et al

in Heart (2005), 91

Vascular brachytherapy (VBT) is the only proven treatment option for patients with in-stent restenosis. In seven randomised trials with almost 1500 patients that evaluated {gamma} (five studies) and ß ... [more ▼]

Vascular brachytherapy (VBT) is the only proven treatment option for patients with in-stent restenosis. In seven randomised trials with almost 1500 patients that evaluated {gamma} (five studies) and ß (two trials) irradiation, target vessel failure reduction ranged from 73% to 34% by VBT compared with conventional angioplasty.1 However, the reported restenosis rates with the active treatment still varied between 17% and 32%.1 We therefore postulated that repeat VBT is safe and efficacious for preventing refractory in-stent restenosis in high risk patients with failed VBT. METHODS Beginning in January 1999, VBT was applied for all patients with in-stent restenosis. VBT was systematically performed with intravascular ultrasound (IVUS) guidance. The repeat procedure was performed with a strontium/yttrium-90 source train (BetaCath, Novoste, Norcross, Georgia, USA). The design and application of this catheter have been described previously.2 The dosimetry was based on the manufacturer’s recommendations but taking into account not the angiographic vessel reference diameter but the external elastic membrane diameter (as determined by IVUS). The mean dose delivered at 2 mm from the source centre was 23.3 (2.2) Gy during the index procedure and 25.3 (2.2) Gy during the repeat intervention. Percutaneous coronary intervention (PCI) was performed according to standard clinical practice. Failed VBT was defined as angina recurrence combined with target vessel failure (as documented by any repeat angiography: premature depending on early symptom recurrence or at the planned six month control). Repeat VBT was considered for patients estimated to be at high risk for refractory in-stent restenosis or if they had a prognostic risk—that is, diffuse or ostial in-stent restenosis or total occlusion, or proximal left anterior descending artery stenosis. Focal edge effect stenoses and non-prognostic lesion locations in symptomatic patients were treated by conventional PCI. Written informed consent was obtained from all patients before intervention. The study was approved by the hospital ethics committee. All VBT patients were prospectively entered in a dedicated database by a person not taking part in the interventions. A combined antiplatelet treatment (aspirin 100 mg and clopidogrel 75 mg daily) was prescribed for at least six months after the index procedure and for one year after the second VBT. Control angiography was mandatory at six months in all VBT patients and systematic long term clinical follow up was carried out. RESULTS Between July 1998 and March 2003, 251 VBT interventions were performed at our institution: 22 patients were treated for primary restenosis prevention and 229 patients for in-stent restenosis. VBT failed in 34 patients (14.8%): 23 underwent conventional PCI and 11 underwent repeat VBT. The baseline clinical and angiographic demographics were comparable for both groups. Concerning the repeat VBT group, mean (SD) age was 60 (7) years, nine patients were men, and two had diabetes. All patients who underwent a repeat procedure had incapacitating angina pectoris. Angina recurred at 7 (2) months (range 4–10) after the first, failed VBT. The restenosis pattern (table 1Go) was diffuse in the majority of patients at the first presentation and remained diffuse with exacerbation to total occlusion in two patients. In the focal restenosis group, two patients had ostial in-stent restenosis. The cause of recurrent in-stent restenosis was an evident geographical miss in two patients (a focal and a diffuse pattern case). IVUS and angioplasty were successful before irradiation therapy in all patients. During repeat VBT, a 40 mm source train was used in seven patients and a pullback technique was required in two because of the length of the restenotic segment. No additional stents were implanted and no evidence of geographical miss was seen at repeat intervention. Table 1Go shows quantitative coronary angiography and IVUS data. During the index procedure, the minimum in-stent luminal area increased from mean (SD) 5.8 (1.8) to 7.5 (1.4) mm2. This area was maintained at the repeat intervention at 7.8 (2.1) mm2 and further expanded to 8.9 (1.8) mm2. All repeat interventions were technically successful and there were no adverse clinical events during the in-hospital phase. [less ▲]

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See detailPalyWeb
Steemans, Philippe ULg

Textual, factual or bibliographical database (2005)

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See detailLe territoire comme lieu commun des questions environnementales
Chrifi, Hamid; Melard, François ULg; Mougenot, Catherine ULg

in Rémy, Élisabeth; November, Valérie; d'Alessandro-Scarpi, C. (Eds.) et al Espaces, savoirs et incertitudes (2005)

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See detailDu cours au dispositif d'apprentissage... ou du rôle d'enseignant à celui de concepteur-tuteur d'activités d'apprentissage à distance. Communication présentée au colloque EIAH 2005, Environnements Informatiques pour l'Apprentissage Humain
Denis, Brigitte ULg; Vandeput, Etienne ULg

Poster (2005)

Nous décrivons une stratégie de mise en œuvre d’un dispositif d’EAD (Enseignement à Distance) nécessitant peu de moyens matériels et logiciels, gérable par un seul enseignant. L’environnement d ... [more ▼]

Nous décrivons une stratégie de mise en œuvre d’un dispositif d’EAD (Enseignement à Distance) nécessitant peu de moyens matériels et logiciels, gérable par un seul enseignant. L’environnement d'apprentissage est basé sur un dosage entre travaux individuels et travaux collaboratifs et sur un schéma d'organisation particulier des activités. Ce dernier et la stratégie mise en place sont adaptables à de nombreux thèmes de réflexion traitables dans le cadre d’une activité à distance. [less ▲]

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See detailTravailleurs lombalgiques : Bases scientifiques des programmes de "retour au travail"
Mairiaux, Philippe ULg

in Documents pour le Médecin du Travail (2005), (101), 23-29

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See detailUntersuchung von Kandidatengenen auf Wurfgrösse beim Schwein: Literaturübersicht und eigene Ergebnisse
Buske, Bernd ULg; Reinecke, Peter; Brockmann, Gudrun

(2005)

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See detailThe electronic Construction and Quality Control in Standardized Testing platform project (e-C&QCST)
Gilles, Jean-Luc ULg; Piette, Sylvie-Anne ULg; Detroz, Pascal ULg et al

in Constantinou, C. P.; Demetriou, D.; al (Eds.) 11th Biennal Conference of the European Association for Research on Learning and Instruction - Multiple Perspectives on Effective Learning Enviroments - Abstracts (2005)

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See detailClosed-form dual perturb and combine for tree-based models
Geurts, Pierre ULg; Wehenkel, Louis ULg

in Proceedings of the International Conference on Machine Learning (ICML 2005) (2005)

This paper studies the aggregation of predictions made by tree-based models for several perturbed versions of the attribute vector of a test case. A closed-form approximation of this scheme combined with ... [more ▼]

This paper studies the aggregation of predictions made by tree-based models for several perturbed versions of the attribute vector of a test case. A closed-form approximation of this scheme combined with cross-validation to tune the level of perturbation is proposed. This yields soft-tree models in a parameter free way, and reserves their interpretability. Empirical evaluations, on classification and regression problems, show that accuracy and bias/variance tradeoff are improved significantly at the price of an acceptable computational overhead. The method is further compared and combined with tree bagging. [less ▲]

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See detailThe Carbon budget of the North Sea
Thomas, H.; Bozec, Y.; de Baar, Hein J. W. et al

in Biogeosciences (2005), 2(1), 87-96

A carbon budget has been established for the North Sea, a shelf sea on the NW European continental shelf. The carbon exchange fluxes with the North Atlantic Ocean dominate the gross carbon budget. The net ... [more ▼]

A carbon budget has been established for the North Sea, a shelf sea on the NW European continental shelf. The carbon exchange fluxes with the North Atlantic Ocean dominate the gross carbon budget. The net carbon budget – more relevant to the issue of the contribution of the coastal ocean to the marine carbon cycle – is dominated by the carbon inputs from rivers, the Baltic Sea and the atmosphere. The North Sea acts as a sink for organic carbon and thus can be characterised as a heterotrophic system. The dominant carbon sink is the final export to the North Atlantic Ocean. More than 90% of the CO2 taken up from the atmosphere is exported to the North Atlantic Ocean making the North Sea a highly efficient continental shelf pump for carbon. [less ▲]

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See detailRegions of the varicella-zoster virus open reading frame 63 latency-associated protein important for replication in vitro are also critical for efficient establishment of latency.
Cohen, Jeffrey I; Krogmann, Tammy; Bontems, Sébastien ULg et al

in Journal of Virology (2005), 79(8), 5069-77

Varicella-zoster virus (VZV) open reading frame 63 (ORF63) is one of the most abundant transcripts expressed during VZV latency in humans, and ORF63 protein has been detected in human ganglia by several ... [more ▼]

Varicella-zoster virus (VZV) open reading frame 63 (ORF63) is one of the most abundant transcripts expressed during VZV latency in humans, and ORF63 protein has been detected in human ganglia by several laboratories. Deletion of over 90% of the ORF63 gene showed that the protein is required for efficient establishment of latency in rodents. We have constructed viruses with a series of mutations in ORF63. While prior experiments showed that transfection of cells with a plasmid expressing ORF63 but lacking the putative nuclear localization signal of the protein resulted in increased expression of the protein in the cytoplasm, we found that ORF63 protein remained in the nucleus in cells infected with a VZV ORF63 nuclear localization signal deletion mutant. This mutant was not impaired for growth in cell culture or for latency in rodents. Replacement of five serine or threonine phosphorylation sites in ORF63 with alanines resulted in a virus that was impaired for replication in vitro and for latency. A series of ORF63 carboxy-terminal mutants showed that the last 70 amino acids do not affect replication in vitro or latency in rodents; however, the last 108 amino acids are important for replication and latency. Thus, regions of ORF63 that are important for replication in vitro are also required for efficient establishment of latency. [less ▲]

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See detailComprehensive two-dimensional gas chromatography with isotope dilution time-of-flight mass spectrometry for the measurement of dioxins and polychlorinated biphenyls in foodstuffs - Comparison with other methods
Focant, Jean-François ULg; Eppe, Gauthier ULg; Scippo, Marie-Louise ULg et al

in Journal of Chromatography. A (2005), 1086(1-2), 45-60

A comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC x GC-TOF-MS) experimental setup was tested for the measurement of seven 2,3,7,8-substituted polychlorinated dibenzo ... [more ▼]

A comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC x GC-TOF-MS) experimental setup was tested for the measurement of seven 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins (PCDDs), ten 2,3,7,8-substituted polychlorinated dibenzofurans (PCDFs), four non-ortho-polychlorinated biphenyls (PCBs), eight mono-ortho-PCBs, and six indicator PCBs (Aroclor 1260) in foodstuff samples. A 40 m RTX-500 (0.18 mm I.D., 0.10 mu m df) was used as the first dimension (D-1) and a 1.5 nn BPX-50 (0.10 mm I.D., 0.10 mu m df) as the second dimension (2 D). The GC x GC chromatographic separation was completed in 45 min. Quantification was performed using C-13-label isotope dilution (11)). Isotope ratios of the selected quantification ions were checked against theoretical values prior to peak assignment and quantification. The dynamic working range spanned three orders of magnitude. The lowest detectable amount of 2,3,7,8-TCDD was 0.2 pg. Fish, pork, and milk samples were considered. On a congener basis, the GC x GC-ID-TOF-MS method was compared to the reference GC-ID high resolution mass spectrometry (HRMS) method and to the alternative GC-ID tandem-in-time quadrupole ion storage mass spectrometry (QIST-MS/MS). PCB levels ranged from low picogram (pg) to low nanogram (ng) per gram of sample and data compared very well between the different methods. For all matrices, PCDD/Fs were at a low pg level (0.05-3 pg) on a fresh weight basis. Although congener profiles were accurately described, RSDs of GC x GC-ID-TOF-MS and GC-QIST-MS/MS were much higher than for GC-ID-HRMS, especially for low level pork and milk. On a toxic equivalent (TEQ) basis, all methods, including the dioxin-responsive chemically activated luciferase gene expression (DR-CALUX) assay, produced similar responses. A cost comparison is also presented. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailQuantitative aspects of the spatial distribution and morphological characteristics of the sea bass (Dicentrarchus labrax L.; Teleostei, Serranidae) trunk lateral line neuromasts.
Faucher, Karine ULg; Lagardère, Jean-Paul; Aubert, Anne

in Brain, Behavior & Evolution (2005), 65(4), 231-43

The results presented herein report quantitative data relative to the distribution and morphological characteristics of both types of neuromasts encountered on the trunk lateral line of the sea bass ... [more ▼]

The results presented herein report quantitative data relative to the distribution and morphological characteristics of both types of neuromasts encountered on the trunk lateral line of the sea bass (Dicentrarchus labrax, L.). These data were obtained from scanning electron micrographs. They indicate that, as expected, each modified scale of the sea bass possessed a single canal neuromast with long axis oriented parallel to the fish's long axis. In contrast to several fish species, two thirds of superficial neuromasts observed herein were oriented perpendicular to the fish's long axis. However, whatever the main orientation of superficial neuromasts, two thirds of their hair bundles were oriented parallel to the long axis of the animal with approximately half of them in the direction of the head. Similar ratios were observed for canal neuromasts whatever the area of the maculae: central or peripheral. For both types of neuromasts it was not possible to clearly distinguish a paired organization of hair bundles with opposing polarities. Superficial neuromasts on each trunk canal scale were located on either the dorsal or ventral side of the canal and appeared to be distributed along the trunk lateral line with a higher probability to be encountered closer to the operculum. The frequency of presence and the average number of superficial neuromasts per scale increased with fish size. We observed a size gradient for canal neuromasts between the operculum and caudal peduncle. This gradation was correlated with a reduction of the width of the central area of the canal segment. Canal neuromasts were always localized in the larger portions of the canal segments. Taken together, these results point out some specific features associated with the sea bass trunk lateral line. With the previous report, they establish the first full description of the trunk lateral line of sea bass and will be useful for upcoming experiments regarding the function of the two types of neuromasts. [less ▲]

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See detailCarbon dioxide and methane emissions from estuaries
Abril, G.; Borges, Alberto ULg

in Greenhouse gases emissions from natural environments and hydroelectric reservoirs: fluxes and processes (2005)

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See detailMax Frisch: Blaubart. Freigesprochen - aber nicht unschuldig? Max Frischs letzte Erzählung: Zwischen Realität und Wahn
Letawe, Céline ULg

in Arte Buchtipp, Reihe Junge Literaturkritik (2005)

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See detailHypertension et diabète
Krzesinski, Jean-Marie ULg; Weekers, Laurent ULg

in Revue Médicale de Liège (2005), 60(5-6, May-Jun), 572-577

Hypertension frequently accompanies diabetes mellitus, as it is present in 50% of diabetic patients. Hypertension can sometimes preceed diabetes. In type 2 diabetes, insulin resistance plays a major role ... [more ▼]

Hypertension frequently accompanies diabetes mellitus, as it is present in 50% of diabetic patients. Hypertension can sometimes preceed diabetes. In type 2 diabetes, insulin resistance plays a major role in the hypertensive risk. In type 1 diabetes, nephropathy is often noted as soon as hypertension is present. Both hypertension and diabetes increase the risk for cardiovascular and renal complications. For their prevention, first of all, modification of the diet with increasing exercise must be proposed, associated to antihypertensive agents with a blood pressure target lower than 130/80 mmHg. Renin-angiotensin blockers constitute the main drug therapy in such patients associated with diuretics or betablocker if angina pectoris is present or even calcium channel blocker when large arteries abnormalities exist. A frequent evaluation of the cardiovascular risk is required together with research of renal dysfunction or microproteinuria. [less ▲]

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See detailYB-1 represses AP1-dependent gene transactivation and interacts with an AP-1 DNA sequence.
Samuel, Shaija; Twizere, Jean-Claude ULg; Bernstein, Lori R

in Biochemical Journal (2005), 388(Pt 3), 921-8

Involvement of the AP-1 (activator protein-1) transcription factor has been demonstrated previously in the regulation of cell proliferation and cell-cycle progression, in the control of cell migration ... [more ▼]

Involvement of the AP-1 (activator protein-1) transcription factor has been demonstrated previously in the regulation of cell proliferation and cell-cycle progression, in the control of cell migration, invasion and metastasis, and in signal transduction, stress responsiveness, DNA replication and DNA repair. YB-1 (Y-box-binding protein-1) has also been implicated in many of these processes. However, the mechanism by which YB-1 mediates these processes is poorly understood. In the present study, we report that overexpression of a transfected gene encoding YB-1 in human HeLa cervical carcinoma cells significantly represses the transactivation of a minimal AP-1 reporter construct in response to the tumour promoter PMA. YB-1 also represses mRNA expression and PMA-induced promoter transactivation of the endogenous AP-1 target gene encoding matrix metalloproteinase-12 (metalloelastase). YB-1 transrepression of both the minimal and matrix metalloproteinase-12 promoter reporter constructs is dependent on the AP-1 sequence. To identify new nuclear proteins that bind specifically to the AP-1 DNA-binding site, we devised a DNA-affinity-chromatography-based assay termed NAPSTER (nucleotide-affinity preincubation specificity test of recognition) and discovered a 49 kDa protein from human cancer cells that binds in a sequence-specific manner to the AP-1 DNA sequence. By tandem MS fragmentation sequencing analyses we determined that p49 is a YB-1. Immunoblotting of the NAPSTER-purified p49 protein using anti-YB-1 antibodies confirmed YB-1 binding to the AP-1 DNA sequence, as did gel mobility-supershift assays using YB-1 antibodies. This is the first report of YB-1 transrepression and interaction at the AP-1 DNA-binding site. [less ▲]

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See detailModern techniques for flood risk analysis: quasi-3D simulations in a GIS environment
Archambeau, Pierre ULg; Erpicum, Sébastien ULg; Dewals, Benjamin ULg et al

in Geophysical Research Abstracts (2005), 7(09348),

Human beings have continuously attempted to adapt their environment to their needs. However, many natural phenomena still remain challenging to control and the populations must undergo sometimes heavily ... [more ▼]

Human beings have continuously attempted to adapt their environment to their needs. However, many natural phenomena still remain challenging to control and the populations must undergo sometimes heavily damaging consequences. It is consequently essential to study these phenomena in order to assess their potential hazards. In particular, the scope of the present paper focus on floods. The intense floods met these last years showed the importance of this phenomenon as well as its many devastating effects. Thanks to recent important breakthroughs, both in the field of conceptual and numerical modelling of complex flows and in the calculation power of computers, it is henceforth possible to study the effects of potential floods on the basis of numerical simulations, with an accuracy never reached beforehand. The Laboratory of Applied Hydrodynamics and Hydraulic Constructions (HACH) of the University of Liege has always made this kind of study one of its core competencies, thanks to • the development of modern and powerful modelling tools (quasi-three dimensional software for flow simulation by finite volume), • the use of a broad range of data enabling a proper representation of the studied fields (topography, occupation of the ground...) • the systematic validation of simulation results. These tools are currently intensively used within the framework of a general study of the flood-prone zones of the Walloon area of Belgium, which corresponds to more than 800 km of rivers. [less ▲]

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See detailVis maior and vis cui resisti non potest
Gerkens, Jean-François ULg

in Ex iusta traditur. Essays in honour of Eric H. Pool, University of South Africa ( Fundamina Editio specialis (2005)

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See detailSodium nitroprusside-induced osteoblast apoptosis is mediated by long chain ceramide and is decreased by raloxifene.
Olivier, Sabine ULg; Fillet, Marianne ULg; Malaise, Michel ULg et al

in Biochemical Pharmacology (2005), 69(6), 891-901

Release of high levels of nitric oxide (NO) is associated with osteoblastic cell death. The mechanisms of NO-induced cytotoxicity are not well documented and it is presently not known if estrogenic ... [more ▼]

Release of high levels of nitric oxide (NO) is associated with osteoblastic cell death. The mechanisms of NO-induced cytotoxicity are not well documented and it is presently not known if estrogenic compounds prevent this effect. We studied the role of ceramides in cell death induced by the NO donor sodium nitroprusside (SNP) and we tested the possibility that 17beta-estradiol, the anti-estrogen ICI 182.780 and two selective estrogen receptor modulators raloxifene and tamoxifen modify osteoblastic cell apoptosis. SNP dose-dependently decreased MC3T3-E1 osteoblast viability, increased NO production in the culture media and enhanced the release of intracellular ceramides C22 and C24. Cell death induced by SNP was partially inhibited when MC3T3-E1 cells were pretreated with raloxifene and tamoxifen but was not modified when the cells were pretreated with 17beta-estradiol or ICI 182.780. Cell death induced by SNP resulted from apoptosis as demonstrated by Annexin-V and propidium iodide labeling and a reduction of SNP-induced MC3T3-E1 apoptosis was confirmed in the presence of raloxifene and tamoxifen. SNP induction of C22 and C24 production was inhibited by a pretreatment with raloxifene but not with 17beta-estradiol. Moreover, the synthetic ceramide C24 (0.75 and 1microM) decreased MC3T3-E1 cell viability and osteoblast cell death induced by C24 was partially decreased by raloxifene and to a lesser extent by 17beta-estradiol. These data demonstrate that SNP-induced cell death is mediated by the long chain ceramides C22 and C24 and that raloxifene protected osteoblast from apoptosis induced by SNP, an effect that might be relevant to its pharmacological properties on bone remodeling. [less ▲]

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