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See detailAn X-ray investigation of the NGC 346 field in the Small Magellanic Cloud - I. The luminous blue variable HD 5980 and the NGC 346 cluster
Nazé, Yaël ULg; Hartwell, J. M.; Stevens, I. R. et al

in Astrophysical Journal (2002), 580(Part 1), 225-234

We present results from a Chandra observation of the NGC 346 cluster. This cluster contains numerous massive stars and is responsible for the ionization of N66, the most luminous H II region and the ... [more ▼]

We present results from a Chandra observation of the NGC 346 cluster. This cluster contains numerous massive stars and is responsible for the ionization of N66, the most luminous H II region and the largest star formation region in the SMC. In this first paper we will focus on the characteristics of the main objects of the field. The NGC 346 cluster itself shows only relatively faint X-ray emission (with L-X(unabs) similar to 1.5x10(34) ergs s(-1)), tightly correlated with the core of the cluster. In the field also lies HD 5980, a luminous blue variable star in a binary (or possibly a triple) system that is detected for the first time at X-ray energies. The star is X-ray bright, with an unabsorbed luminosity of L-X(unabs) similar to 1.7x10(34) ergs s(-1), but needs to be monitored further to investigate its X-ray variability over a complete 19 day orbital cycle. The high X-ray luminosity may be associated either with colliding winds in the binary system or with the 1994 eruption. HD 5980 is surrounded by a region of diffuse X-ray emission, which is a supernova remnant. While it may be only a chance alignment with HD 5980, such a spatial coincidence may indicate that the remnant is indeed related to this peculiar massive star. [less ▲]

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See detailCutting balloon angioplasty for the prevention of restenosis: Results of the cutting balloon global randomized trial
Mauri, L.; Bonan, R.; Weiner, B. H. et al

in American Journal of Cardiology (2002), 90(10), 1079-1083

The cutting balloon (CB) is a specialized device designed to create discrete longitudinal incisions in the atherosclerotic target coronary segment during balloon inflation. Such controlled dilatation ... [more ▼]

The cutting balloon (CB) is a specialized device designed to create discrete longitudinal incisions in the atherosclerotic target coronary segment during balloon inflation. Such controlled dilatation theoretically reduces the force needed to dilate an obstructive lesion compared with standard percutaneous transluminal coronary angioplasty (PTCA). We report a multicenter, randomized trial comparing the incidence of restenosis after CB angioplasty versus conventional balloon angioplasty in 1,238 patients. Six hundred seventeen patients were randomized to CB treatment, and 621 to PTCA. The mean reference vessel diameter was 2.86 +/- 0.49 mm, mean lesion length 8.9 +/- 4.3 mm, and prevalence of diabetes mellitus in patients was 13%. The primary end point, the 6-month binary angiographic restenosis rate, was 31.4% for CB and 30.4% for PTCA (p = 0.75). Acute procedural success, defined as the attainment of <50% diameter stenosis without in-hospital major adverse cardiac events, was 92.9% for CB and 94.7% for PTCA (p = 0.24). Freedom from target vessel revascularization was slightly higher in the CB arm (88.5% vs 84.6%, log-rank p = 0.04). Five coronary perforations occurred in the CB arm only (0.8% vs 0%, p = 0.03). At 270 days, rates of myocardial infarction, death, and total major adverse cardiac events for CB and PTCA were 4.7% versus 2.4% (p = 0.03), 1.3% versus 0.3% (p = 0.06), and 13.6% versus 15.1% (p = 0.34), respectively. In summary, the proposed mechanism of controlled dilatation did not reduce the rate of angiographic restenosis for the CB compared with conventional balloon angioplasty. CB angioplasty should be reserved for difficult lesions in which controlled dilatation is believed to provide a better acute result compared with balloon angioplasty alone. (C) 2002 by Excerpta Medica, Inc. [less ▲]

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See detailLernout & Hauspie, Neuroplanet, SABENA ... ou quand les rêves indomptés s’écrasent contre les murs de la réalité
Van Caillie, Didier ULg

Article for general public (2002)

This chronicle analyses the reasons for some important recent firm failures in Belgium and insists on the crucial role played by growth management in the evolution of the firm

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See detailPitx factors are involved in basal and hormone-regulated activity of the human prolactin promoter
Quentien, M. H.; Manfroid, Isabelle ULg; Moncet, D. et al

in Journal of Biological Chemistry (2002), 277(46), 44408-44416

The pituitary-specific POU homeodomain factor Pit-1 likely interacts with other factors for cell-specific expression of prolactin. Here we identify the paired-like homeobox transcription factors Pitx1 and ... [more ▼]

The pituitary-specific POU homeodomain factor Pit-1 likely interacts with other factors for cell-specific expression of prolactin. Here we identify the paired-like homeobox transcription factors Pitx1 and Pitx2 as factors functionally activating the proximal human prolactin promoter (hPRL-164luc). Using in vitro binding assays and a series of site-specific mutations of the proximal hPRL promoter, we mapped the 131 and B2 bicoid sites involved in Pitx-mediated transactivation of the hPRL-164luc construct. In somatolactotroph GH4C1 cells, basal proximal hPRL promoter activity was inhibited by a Pitx2 dominant-negative form in a dose-dependent manner, whereas binding disruptive mutations in the Pitx sites significantly reduced basal activity of the promoter. We also show that synergistic activation of hPRL-164luc by Pitx2 and Pit-1 requires the integrity of the B2 Pitx binding site, and at least one of the P1 and P2 Pit-1 response elements. In addition, mutation in the B2 Pitx site results in attenuation of the promoter's responsiveness to forskolin, thyrotropin-releasing hormone, and epidermal growth factor. Conversely, Pitx1 or Pitx2 overexpression in GH4C1 cells leads to an enhancement of the drugs stimulatory effects. Altogether, these results suggest that full responsiveness to several signaling pathways regulating the hPRL promoter requires the B2 Pitx binding site and that Pitx factors may be part of the proteic complex involved in these regulations. Finally, in situ hybridization analysis showing coexpression of the PRL and Pitx2 genes in rat and human lactotroph cells corroborates the physiological relevance of these results. [less ▲]

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See detailProduction planning problems in printed circuit board assembly
Crama, Yves ULg; van de Klundert, Joris; Spieksma, Frits CR

in Discrete Applied Mathematics (2002), 123(1-3), 339-361

This survey describes some of the main optimization problems arising in the context of production planning for the assembly of printed circuit boards. The discussion is structured around a hierarchical ... [more ▼]

This survey describes some of the main optimization problems arising in the context of production planning for the assembly of printed circuit boards. The discussion is structured around a hierarchical decomposition of the planning process into distinct optimization subproblems, addressing issues such as the assignment of board types to machine groups, the allocation of component feeders to individual machines, the determination of optimal production sequences, etc, The paper reviews the literature on this topic with an emphasis on the most recent developments, on the fundamental structure of the mathematical models and on the relation between these models and some 'environmental' variables such as the layout of the shop or the product mix. (C) 2002 Elsevier Science B.V, All rights reserved. [less ▲]

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See detailBenchmarks for the forward observables at RHIC, the Tevatron-run II, and the LHC
Cudell, Jean-René ULg; Ezhela, Vladimir V.; Gauron, P. et al

in Physical Review Letters (2002), 89(20), 201801

We present predictions on the total cross sections and on the ratio of the real part to the imaginary part of the elastic amplitude (rho parameter) for present and future pp and pbar p colliders, and on ... [more ▼]

We present predictions on the total cross sections and on the ratio of the real part to the imaginary part of the elastic amplitude (rho parameter) for present and future pp and pbar p colliders, and on total cross sections for gamma p -> hadrons at cosmic-ray energies and for gamma gamma-> hadrons up to sqrt{s}=1 TeV. These predictions are based on an extensive study of possible analytic parametrisations invoking the biggest hadronic dataset available at t=0. The uncertainties on total cross sections, including the systematic errors due to contradictory data points from FNAL, can reach 1.9% at RHIC, 3.1% at the Tevatron, and 4.8% at the LHC, whereas those on the rho parameter are respectively 5.4%, 5.2%, and 5.4%. [less ▲]

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See detailAlgorithms for mathematical morphology
Van Droogenbroeck, Marc ULg

Scientific conference (2002, November 08)

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See detailL’enseignement de l’histoire au carrefour ?
Jadoulle, Jean-Louis ULg

Article for general public (2002)

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See detailControlled free-radical polymerization products using new controlled agents
Vanhoorne, Pierre; Meyer, Rolf-Volker; Detrembleur, Christophe ULg et al

Patent (2002)

A process for the production of polymers by means of pseudo-living free-radical polymerization is disclosed. The process entails (i) reacting a polymerizable vinyl monomer with nitrogen monoxide and at ... [more ▼]

A process for the production of polymers by means of pseudo-living free-radical polymerization is disclosed. The process entails (i) reacting a polymerizable vinyl monomer with nitrogen monoxide and at least one initiator to prepare a free-radical intermediate product, and (ii) polymerizing the intermediate product optionally together with one or more additional monomers and/or with a free-radical initiator. [less ▲]

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See detailA model for the pion structure function
Bissey, F.; Cudell, Jean-René ULg; Cugnon, Joseph ULg et al

in Physics Letters B (2002), 547(3-4), 210-218

The pion structure function is investigated in a simple model, where pion and constituent quark fields are coupled through the simplest pseudoscalar coupling. The imaginary part of the forward gamma*pi ... [more ▼]

The pion structure function is investigated in a simple model, where pion and constituent quark fields are coupled through the simplest pseudoscalar coupling. The imaginary part of the forward gamma*pi --> gamma*pi evaluated and related to the structure functions. It is shown that the introduction of non-perturbative effects linked to the size of the pion and preserving gauge invariance, allows a connection with the quark distribution. It is predicted that higher-twist terms become negligible for Q(2) larger than similar to 2 GeV2 and that quarks in the pion have a momentum fraction smaller than in the proton case. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailSelective encryption of uncompressed and compressed images
Van Droogenbroeck, Marc ULg

Scientific conference (2002, November 06)

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See detailTranscription of the human prolactin gene in mammary cells
Baudhuin, A.; Manfroid, Isabelle ULg; Van de Weerdt, Cécile ULg et al

in Annals of the New York Academy of Sciences (2002), 973

Expression of human prolactin in the Mammary gland, one of the main target organs of this hormone, leads to the formation of an autocrine-paracrine proliferative loop in this tissue. Involvement of ... [more ▼]

Expression of human prolactin in the Mammary gland, one of the main target organs of this hormone, leads to the formation of an autocrine-paracrine proliferative loop in this tissue. Involvement of prolactin in normal and neoplastic mammary development triggered the interest in transcriptional regulation of the human prolactin gene in mammary cells. Analysis of this regulation, and comparison to that in the pituitary, will contribute to a better understanding of mammary gland development and tumor formation. Here we present the first extensive analysis of the transcriptional regulation of the human prolactin gene in human mammary tumor cells. [less ▲]

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See detailLe cas clinique du mois. Constipation et syndrome de masse abdominale chez une patiente de 51 ans
Detrembleur, Nancy ULg; Delbecque, Katty ULg; Thiry, Albert ULg et al

in Revue Médicale de Liège (2002), 57(11), 688-91

A 51-year old patient consults for abdominal swelling and persistent constipation. Clinical exploration shows the presence of a left iliac fossa tumor corresponding to a papillary serous adenocarcinoma of ... [more ▼]

A 51-year old patient consults for abdominal swelling and persistent constipation. Clinical exploration shows the presence of a left iliac fossa tumor corresponding to a papillary serous adenocarcinoma of the fallopian tube after macroscopic and microscopic examination. The diagnostic and therapeutic problems caused by this rare gynecologic tumor are discussed. [less ▲]

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See detailMesure de coefficient de dilatation thermique de matériaux composites par holographie dynamique
Georges, Marc ULg; Ryhon, S.; Thizy, Cédric ULg et al

in Actes du 3e colloque francophone Méthodes et Techniques Optiques pour l'Industrie (2002, November)

Une méthode de mesure de coefficient de dilatation thermique par interférométrie holographique est présentée. Nous passerons rapidement en revue le principe de la caméra holographique dynamique utilisée ... [more ▼]

Une méthode de mesure de coefficient de dilatation thermique par interférométrie holographique est présentée. Nous passerons rapidement en revue le principe de la caméra holographique dynamique utilisée pour la mesure puis nous montrerons l’application à plusieurs cas concrets de R&D industriels. Il s’agit d’éprouvettes simples de matériaux composite et de structures plus complexes alliant ces matériaux à des métaux. La mesure consiste à observer le déplacement différentiel entre la partie supérieure de l’objet étudié et une plaque de base sur laquelle il est posé et ce lorsqu’un échauffement ou refroidissement de l’ensemble est opéré [less ▲]

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See detailConnexin expression and gap junctional intercellular communication in human first trimester trophoblast
Cronier, L.; Defamie, N.; Dupays, L. et al

in Molecular Human Reproduction (2002), 8(11), 1005-1013

Connexin (Cx) expression and gap junctional intercellular communication (GJIC) are involved in development and differentiation processes, and recently mutation of connexin genes has been implicated in ... [more ▼]

Connexin (Cx) expression and gap junctional intercellular communication (GJIC) are involved in development and differentiation processes, and recently mutation of connexin genes has been implicated in pathologies. In the human placenta, two distinct differentiation pathways of cytotrophoblastic cells coexist and lead to a fusion phenotype (villous trophoblast) and a proliferative/invasive phenotype (extravillous trophoblast). Here we characterized in situ and in vitro the expression of Cx transcripts and proteins in the villous and extravillous trophoblast of first trimester placenta. In addition, the GJIC functionality was investigated using the gap-fluorescence recovery after photobleaching (gap-FRAP) method. We demonstrated in the villous trophoblast the presence of Cx43 mRNA and of Cx43 protein localized between cytotrophoblastic cells and between cytotrophoblastic cells and syncytiotrophoblast. In vitro, a transient functional gap junctional intertrophoblastic communication was demonstrated during the trophoblast fusion leading to the multinucleated syncytiotrophoblast. During the proliferative process of the extravillous trophoblast, Cx40 is expressed in the proximal part of the cell columns. When cytotrophoblastic cells were cultured on Matrigel(R) for 2 days, alpha5beta1 integrin expression was observed concomitant with the presence of Cx40 mRNA and of Cx40 protein between the cells. No evidence for a GJIC was detected in this induced extravillous phenotype. In addition, Cx32 was detected between some aggregated cells after 72 h of culture. Our data show that the presence of Cx43 allows an inter-trophoblastic GJIC and is associated with the fusion process leading to the villous syncytiotrophoblast and that the presence of Cx40 does not allow GJIC and is associated with the extravillous phenotype. [less ▲]

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See detailL'evaluation de la qualite de vie dans les essais therapeutiques: un pas vers une approche holistique de la sante
Ethgen, Olivier ULg; Reginster, Jean-Yves ULg

in Revue Médicale de Liège (2002), 57(11), 695-700

The concept of quality of life has been widely developed over the last two decades. As they provide subjective assessment of health, quality of life measures may be broadly and relevantly applied in many ... [more ▼]

The concept of quality of life has been widely developed over the last two decades. As they provide subjective assessment of health, quality of life measures may be broadly and relevantly applied in many areas. Numerous measures are available today to perform discriminative, evaluative or analytical studies in the epidemiological, the therapeutic or the health economic fields. Such measures are increasingly used and may be added to clinical, biological or radiographical criteria to assess medical benefits and health outcomes in order to strengthen decisional choice in health. [less ▲]

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See detailExperimental evidence for N recycling in the leaves of the seagrass Posidonia oceanica
Lepoint, Gilles ULg; Defawe, Olivier; Gobert, Sylvie ULg et al

in Journal of Sea Research (2002), 48(3), 173-179

A one-year in situ experiment using N-15 as a tracer was designed to assess the N recycling in the leaves of the seagrass Posidonia oceanica (L.) Delile. R oceanica was shown to partly recycle the ... [more ▼]

A one-year in situ experiment using N-15 as a tracer was designed to assess the N recycling in the leaves of the seagrass Posidonia oceanica (L.) Delile. R oceanica was shown to partly recycle the internal nitrogen pool of its leaves in order to contribute to new leaf growth. The leaves sampled in June 1999 contained 20% of the quantity of N-15 found in June 1998. N recycling caused a difference between N and biomass turnover rate (0.8 vs 1.3 y(-1)) of Posidonia leaves. This 40% difference should correspond to the contribution of recycled N to the annual N requirement of Posidonia leaves. The N recycling appears to be insufficient to significantly reduce the quantitative impact of N loss due to autumnal leaf fall. However, new leaf growth between June and October is mainly sustained by this recycling because the tracer concentration in new leaves was the same as in the other leaves. By contrast, tracer concentration decreased drastically between October 1998 and June 1999, showing the more important contribution of N uptake during winter and spring. Nevertheless, recycling occurs throughout the year as demonstrated by the presence of tracer in the youngest leaves of shoots sampled one year after the tracer addition. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailEffect of aggregation on bacteriochlorin a triplet-state formation: A laser flash photolysis study
Damoiseau, Xavier; Tfibel, Francis; Hoebeke, Maryse ULg et al

in Photochemistry & Photobiology (2002), 76(5), 480-485

Bacteriochlorin a (BCA) is a potential photosensitizer for photodynamic therapy of cancer. It has been shown previously that the photoefficiency of the dye is mainly dependent on singlet oxygen (O-1(2 ... [more ▼]

Bacteriochlorin a (BCA) is a potential photosensitizer for photodynamic therapy of cancer. It has been shown previously that the photoefficiency of the dye is mainly dependent on singlet oxygen (O-1(2)) generation. Nanosecond laser flash photolysis was used to produce and to investigate the excited triplet state of the dye in methanol, phosphate buffer and dimiristoyl-L-alpha-phosphatidylcholine (DMPC) liposomes. The transients were characterized in terms of their absorption spectra, decay kinetics, molar absorption coefficients and formation quantum yield of singlet-triplet intercrossing. The lifetime of the BCA triplet state was measured at room temperature. The triplet-state quantum yield is quite high in methanol (0.7) and in DMPC (0.4) but only 0.095 in phosphate buffer. In the last case, BCA is in a monomer-dimer equilibrium, and the low value of the quantum yield observed was ascribed to the fact the triplet state is only formed by the monomers. [less ▲]

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See detailProceeds from the European workshop: GBS neonatal disease prevention
MELIN, Pierrette ULg

in de la Rosa, Manuel (Ed.) Proceedings from the European workshop: GBS neonatal disease prevention (2002)

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