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See detailAnomalies hypophysaires chez le sujet age avec insuffisance renale chronique
Valdes Socin, Hernan Gonzalo ULg; Magis, Delphine ULg; Betea, Daniela ULg et al

in Revue Médicale de Liège (2002), 57(6), 375-381

Chronic renal failure (CRF) in the elderly is a cause of multiple endocrine dysfunctions. The three most common pituitary axes involved are the thyrotrope, lactotrope and gonadotrope axes. Thyroid ... [more ▼]

Chronic renal failure (CRF) in the elderly is a cause of multiple endocrine dysfunctions. The three most common pituitary axes involved are the thyrotrope, lactotrope and gonadotrope axes. Thyroid dysfunction may be the consequence of thyroid or pituitary failure. Hyperprolactinemia results in gonadal failure and is present in 30% of patients. Early presentation of menopause and andropause are common in patients with CRF. Sexual hormonal replacement is controversial and must be individually tailored. We propose a systematic screening in the elderly with CRF: determination of TSH, TPO antibodies and cervical palpation, measures of PRL, LH, FSH and testosterone to explore lactotrope and gonadotrope axis. [less ▲]

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See detailStructural basis of alpha-amylase activation by chloride
Aghajari, N.; Feller, Georges ULg; Gerday, Charles ULg et al

in Protein Science : A Publication of the Protein Society (2002), 11(6), 1435-1441

To further investigate the mechanism and function of allosteric activation by chloride in some alpha-amylases, the structure of the bacterial alpha-amylase from the psychrophilic micro-organism ... [more ▼]

To further investigate the mechanism and function of allosteric activation by chloride in some alpha-amylases, the structure of the bacterial alpha-amylase from the psychrophilic micro-organism Pseudoalteromonas haloplanktis in complex with nitrate has been solved at 2.1 Angstrom, as well as the structure of the mutants Lys300Gln (2.5 Angstrom) and Lys300Arg (2.25 Angstrom). Nitrate binds strongly to alpha-amylase but is a weak activator. Mutation of the critical chloride ligand Lys300 into Gln results in a chloride-independent enzyme, whereas the mutation into Arg mimics the binding site as is found in animal alpha-amylases with, however, a lower affinity for chloride. These structures reveal that the triangular conformation of the chloride ligands and the nearly equatorial coordination allow the perfect accommodation of planar trigonal monovalent anions such as NO3-, explaining their unusual strong binding. It is also shown that a localized negative charge such as that of Cl-, rather than a delocalized charge as in the case of nitrate, is essential for maximal activation. The chloride-free mutant Lys300Gln indicates that chloride is not mandatory for the catalytic mechanism but strongly increases the reactivity at the active site. Disappearance of the putative catalytic water molecule in this weakly active mutant supports the view that chloride helps to polarize the hydrolytic water molecule and enhances the rate of the second step in the catalytic reaction. [less ▲]

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See detailInfluence of sexual genotype on the behaviour of females (genotype WZ) and pseudofemales (genotype ZZ) in the tilapia Oreochromis aureus
Ovidio, Michaël ULg; Desprez, Damien; Mélard, Charles ULg et al

in Aquatic Living Resources (2002), 15(3), 163-167

17alpha-ethynylestradiol sex-reversed males of Oreochromis aureus (pseudofemales, DeltaF, genotype ZZ) are used in aquaculture to produce a male monosex population by crossing with ZZ homogametic normal ... [more ▼]

17alpha-ethynylestradiol sex-reversed males of Oreochromis aureus (pseudofemales, DeltaF, genotype ZZ) are used in aquaculture to produce a male monosex population by crossing with ZZ homogametic normal males. When placed with males (M) and females (F) in the same spawning tank, the spawning rate of F is higher than for DeltaF. In order to understand this phenomenon, comparisons were made between the behaviour of 18 F (446 +/- 96 mm) and 18 DeltaF (401 +/- 59 mm). DeltaF showed a more aggressive behaviour and were significantly more dominant than normal F in fighting pair experiments (F x DeltaF) or in fighting group experiments in four different stocking densities (8, 12, 16 and 83 fish 10(-3) l with F/DeltaF ratio = 1). DeltaF were also more aggressive towards males than F were. The results support the idea that behavioural differences exist between F and DeltaF These differences are probably due to the effect of the sexual genotype on behaviour. (C) 2002 Ifremer/CNRS/Inra/IRD/Cemagref/Editions scientifiques et medicales Elsevier SAS. All rights reserved. [less ▲]

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See detailHolographic interferometers based on photorefractive crystals for vibration measurements
Georges, Marc ULg; Thizy, Cédric ULg; Ryhon, Sébastien et al

Conference (2002, June)

Photorefractive crystals offer many advantages over other classical holographic recording media. They allow fast in-situ processable holographic recording as well as indefinite reusability. Moreover high ... [more ▼]

Photorefractive crystals offer many advantages over other classical holographic recording media. They allow fast in-situ processable holographic recording as well as indefinite reusability. Moreover high signal-to-noise ratio can be reached as well as high resolutions. We present several types of holographic instruments using such materials. Here we will emphasize their applications in vibration measurements. A first one is based on the classical stroboscopic technique, a second one uses a pulsed laser. [less ▲]

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See detailOvarian endometriosis and peritoneal endometriosis: are they different entities from a fertility perspective?
Nisolle, Michelle ULg

in Current Opinion in Obstetrics & Gynecology (2002), 14(3), 283-288

This review summarizes the recent literature concerning new data on the pathogenesis of peritoneal endometriosis and its natural evolution. Indeed, the main concern in endometriosis is the choice of ... [more ▼]

This review summarizes the recent literature concerning new data on the pathogenesis of peritoneal endometriosis and its natural evolution. Indeed, the main concern in endometriosis is the choice of treatment in cases of infertility problems: medical or surgical. This concern could hypothetically be avoided if endometriosis were considered as a spontaneously regressive phenomenon. The present paper also discusses the risk of recurrence and the results of in-vitro fertilization and embryo transfer in cases of ovarian endometriosis. Whatever type of surgery is performed, the results of in-vitro fertilization and embryo transfer are not impaired, especially if damage to the ovarian cortex is avoided. Further studies are required to determine if oocytes from endometriosis patients are altered and could be responsible for the development of lower quality embryos. [less ▲]

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See detailEpimerization study on [18F]FDG produced by an alkaline hydrolysis on solid support under stringent conditions
Mosdzianowski, C.; Lemaire, Christian ULg; Simoens, F. et al

in Applied Radiation & Isotopes (2002), 56(6), 871-875

Since 1998, routine [18F]FDG syntheses are being carried out by alkaline hydrolysis on a solid support, i.e. the labeled intermediate is trapped on a tC18 solid phase extraction cartridge, purified and ... [more ▼]

Since 1998, routine [18F]FDG syntheses are being carried out by alkaline hydrolysis on a solid support, i.e. the labeled intermediate is trapped on a tC18 solid phase extraction cartridge, purified and finally hydrolyzed within the cartridge, at room temperature, using sodium hydroxide. The present study demonstrated that no epimerization of [18F]FDG to [18F]FDM occurs even when 12 N NaOH is used and when the hydrolysis time is extended up to 1 h. The alkaline hydrolysis on solid support appears to be a simple method leading to [18F]FDG with high purity. [less ▲]

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See detailL'image du mois. Desinsertion d'anneau mitral prothetique dans les suites d'une plastie mitrale
Nellessen, Eric ULg; LANCELLOTTI, Patrizio ULg; Yans, T. et al

in Revue Médicale de Liège (2002), 57(6), 361-2

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See detailThe GENIE nulling experiment
Absil, Olivier ULg; Gondoin, Ph; den Hartog, R. et al

in Combes, F. (Ed.) SF2A-2002: Semaine de l'Astrophysique Francaise (2002, June)

Within the frame of the Darwin program, the European Space Agency and the European Southern Observatory (ESO) intend to build a ground-based technology demonstrator called Darwin-GENIE, using the Very ... [more ▼]

Within the frame of the Darwin program, the European Space Agency and the European Southern Observatory (ESO) intend to build a ground-based technology demonstrator called Darwin-GENIE, using the Very Large Telescope Interferometer (VLTI). The main objective of GENIE is to gain experience in the manufacture and operation of a nulling interferometer representative of the ESA IRSI-Darwin space mission. GENIE will prepare the Darwin science programme through a systematic search for exo-zodiacal dust clouds around Darwin candidate targets. GENIE also aims to perform Darwin related science including the detection of low-mass companions (if possible, hot Jupiters) around nearby stars. The prospective performances of some candidate configurations are presented in this paper. [less ▲]

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See detailLa recherche en matière de faillite d’entreprise : un état de sa situation et de ses perspectives d'avenir
Van Caillie, Didier ULg; Dighaye, Andrée

Conference (2002, June)

This paper proposes a state-of-the-art of the research on business failure and discusses some promising avenues for research and evolution perspectives.

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See detailL'évolution de l'activité de contrôle de gestion en contexte PME : une focalisation sur le suivi des marges et le pilotage du changement
Van Caillie, Didier ULg

in Working Paper du CEPE (2002, June), 2002(01),

L'activité de contrôle de gestion menée en contexte PME est aujourd'hui devenue véritablement bicéphale, intégrant à la fois un contrôle de gestion opérationnel dominé par la volonté de maîtrise à court ... [more ▼]

L'activité de contrôle de gestion menée en contexte PME est aujourd'hui devenue véritablement bicéphale, intégrant à la fois un contrôle de gestion opérationnel dominé par la volonté de maîtrise à court terme des coûts et surtout des marges qui traversent la vie quotidienne de l'entreprise au travers de toutes ses activités et un contrôle de gestion stratégique dominé par la volonté de permettre le pilotage effectif du changement dans l'entreprise, changement lui-même issu de l'impérieuse nécessité de continuellement adapter chaque PME aux nouvelles contraintes et opportunités offertes par son environnement. [less ▲]

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See detailDéveloppement de modèles hydrosédimentaires pour la gestion de grands ouvrages hydrauliques
Dewals, Benjamin ULg

Master of advanced studies dissertation (2002)

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See detailA comparison of the training value of two types of anesthesia simulators: Computer screen-based and mannequin-based simulators
Nyssen, Anne-Sophie ULg; Larbuisson, Robert ULg; Janssens, Marc ULg et al

in Anesthesia and Analgesia (2002), 94(6), 1560-1565

In this study, we compared two different training simulators (the computer screen-based simulator versus the full-scale simulator) with respect to training effectiveness in anesthesia residents ... [more ▼]

In this study, we compared two different training simulators (the computer screen-based simulator versus the full-scale simulator) with respect to training effectiveness in anesthesia residents. Participants were evaluated in the management of a simulated preprogrammed scenario of anaphylactic shock using two variables: treatment score and diagnosis time. Our results showed that simulators can contribute significantly to the improvement of performance but that learning in treating simulated crisis situations such as anaphylactic shock did not significantly vary between full-scale and computer screen-based simulators. Consequently, the initial decision on whether to use a full-scale or computer screen-based training simulator should be made on the basis of cost and learning objectives rather than on the basis of technical or fidelity criteria. Our results support the contention that screen-based simulators are good devices to acquire technical skills of crisis management. Mannequin-based simulators would probably provide better training for behavioral aspects of crisis management, such as communication, leadership, and interpersonal conflicts, but this was not tested in the current study. IMPLICATIONS: We compared two different training simulators (computer screen-based versus full-scale) for training anesthesia residents to better document the effectiveness of such devices as training tools. This is an important issue, given the extensive use and the high cost of mannequin-based simulators in anesthesiology. [less ▲]

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See detailFeature extraction for non-linear model updating
Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg

in International Conference on Structural Dynamics Modelling, Funchal, 2002 (2002, June)

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See detail"Arrachez-moi ce coeur!": de la crainte du rejet au délire après transplantation cardiaque
Triffaux, Jean-Marc ULg; Demoulin, J. C.; Limet, Raymond ULg

in Revue Médicale de Liège (2002), 57(6), 389-92

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See detailStudy of CCD mosaic configurations for the ILMT: Astrometry and photometry of point sources in the absence of a TDI corrector
Vangeyte, B.; Manfroid, Jean ULg; Surdej, Jean ULg

in Astronomy and Astrophysics (2002), 388(2), 712-731

The image deformations induced by the time-delay integration (TDI) mode, used with a CCD camera at the prime focus of a Liquid Mirror Telescope (LMT), can be corrected for by a system of lenses ... [more ▼]

The image deformations induced by the time-delay integration (TDI) mode, used with a CCD camera at the prime focus of a Liquid Mirror Telescope (LMT), can be corrected for by a system of lenses, simultaneously with the optical aberrations. However, before adopting the design of a TDI corrector, we may wonder what is the importance of the TDI image deformations and how to possibly reduce these by choosing optimal mosaic configurations of CCDs, covering an equivalent field of view. In a first step, we have simulated the point spread function (PSF) deformation due to the TDI mode only, for different selected mosaic configurations. We have then estimated the importance of the astrometric and photometric errors induced by the TDI deformation. By simulating star fields with the same synthetic PSF and taking into account realistic sources of noise (cf. CCD readout noise, photon noise and sky background), we have derived the limiting magnitudes for photometry and astrometry for the case of a 4 m LMT. [less ▲]

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See detailHypertension artérielle et artériopathie
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2002), 57(6), 370-374

High blood pressure as other factors of atherosclerosis is a well-known risk factor for development of peripheral arterial disease. A patient characterized by an isolated systolic hypertension and a low ... [more ▼]

High blood pressure as other factors of atherosclerosis is a well-known risk factor for development of peripheral arterial disease. A patient characterized by an isolated systolic hypertension and a low ankle/arm systolic blood pressure ratio very often presents coronary heart disease. Practising exercise (such as walking), stoping smoking and following an adapted diet are recommended. Hypertension treatment must be considered as a secondary prevention approach with a blood pressure normalisation as a target. All the different classes of antihypertensive drugs can be used, but with a marked preference for angiotensin converting enzyme (with caution for the renal artery stenosis risk) and for betablockers to improve the potential coronary heart disease (care is needed in the presence of severe peripheral arterial disease). [less ▲]

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See detailCultiver un avantage technologique dans les réseaux, le cas de la Compagnie Générale des Eaux
Froehlicher, Thomas ULg; Baroncelli, Allessandro; Assens, Christophe

in Annales des Mines. Gérer et Comprendre (2002), 68

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See detailPeut-on concilier la solidarité et la justice ? Le cas de l'insertion wallonne
Jacquemain, Marc ULg

in Déviance et Société (2002), 26

La politique d'insertion sociale peut avoir une fonction latente et une fonction manifeste. La fonction manifeste est de remettre les chômeurs à l'emploi. La fonction latente semble plutôt être de les ... [more ▼]

La politique d'insertion sociale peut avoir une fonction latente et une fonction manifeste. La fonction manifeste est de remettre les chômeurs à l'emploi. La fonction latente semble plutôt être de les maintenir socialisés. Mais la mise en oeuvre de la fonction latente n'est idéologiquement possible que sous le couvert de la fonction manifeste [less ▲]

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