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See detailAnalgésie par blocs nerveux périphériques continus dans le cadre des soins de plaies cutanées
Lecoq, Jean-Pierre; Jacquemin, Denise ULg; Lamy, Maurice ULg et al

in Revue Médicale de Liège (2008), 63(1), 3-16

We present the case of a patient with a circumferential venous ulcer at the level of the calf. She is hospitalized for surgical treatment by continuous aspiration dressing and coverage with skin graft ... [more ▼]

We present the case of a patient with a circumferential venous ulcer at the level of the calf. She is hospitalized for surgical treatment by continuous aspiration dressing and coverage with skin graft. This patient presents a history of chronic pain, on which classical medications have few effects and are accompanied by side effects. After discussion with the patient, a double continuous peripheral nervous block (femoral and sciatic nerve) is set up to improve the tolerance to wound dressing. This technique presents favorable antalgic results. The indications and the different techniques of block performance (by electrostimulation or echo-guided) are described. The infectious risks related to the presence of catheter near cutaneous wounds are clarified according to recent data of literature. The relevance of these techniques in correlation with the development of chronic pain and on the trophicity of the wounds are also discussed. [less ▲]

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See detailGastroenterology - Clinical and genetic factors associated with sacroiliitis in Crohn's disease
Peeters, Harald; Cruyssen, Bert Vander; Mielants, Herman et al

in Journal of Gastroenterology and Hepatology (2008), 23(1), 132-137

Background and Aim: Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra-intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI with ... [more ▼]

Background and Aim: Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra-intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI with other clinical features of CD are limited. Association of SI with CARD15 polymorphisms has recently been suggested. In a multicenter study, we investigated the association of SI in CD patients with clinical phenotypes, other EIM and CARD15 polymorphisms. Methods: Radiographs of the sacroiliac joints were taken in 251 CD patients from three Belgian university hospitals and scored by two blinded rheumatologists. Clinical features were obtained from medical records. Forty-three percent of patients carried at least one CARD15 polymorphism. Results: Sacroiliitis, defined as the presence of at least grade 2 unilateral changes, was diagnosed in 65 of the 244 scorable radiographs (27%). Only 16 of these patients were previously diagnosed with ankylosing spondylitis (AS). HLA-B27 positivity was observed in 53% of patients with AS and 7% of patients with radiographic SI. In univariate and multivariate analysis, associations between the presence of SI and peripheral arthritis (P = 0.005) and between AS and uveitis (P = 0.005) were found. No associations with other recorded clinical features or with CARD15 polymorphisms were observed. Conclusion: We confirm the high prevalence of radiographic sacroiliitis in a multicenter CD cohort. Uveitis is only associated with AS whereas all patients with SI are more prone to develop peripheral arthritis during their disease course, suggesting similar pathogenetic mechanisms in the development of these EIM. The previously reported association between SI and CARD15 polymorphisms was not confirmed. [less ▲]

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See detailLes maladies vénériennes chez le cheval
Ponthier, Jérôme ULg; Deleuze, Stefan ULg

in sBs Magazine (2008)

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See detailActes du colloque 'Enseignement du lexique et des terminologies : corpus, stratégies et méthodes'
Thiry, Bernard ULg

in Cahiers de la Recherche en UER-Langues de HEC-ULg (2008), (2),

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See detailSoil physical fertility: thesis project for water-soil-plant model improvement
Beckers, Eléonore ULg; Degre, Aurore ULg

Poster (2008, January)

Quantities of nutrients like N, P and K in the soil are generally assumed to be the more important parameters of its fertility. The physical fertility of the soil such as water holding capacity, hydraulic ... [more ▼]

Quantities of nutrients like N, P and K in the soil are generally assumed to be the more important parameters of its fertility. The physical fertility of the soil such as water holding capacity, hydraulic conductivity…is often ignored. The present thesis project purposes the development of a physically-based model linking agricultural practices and changes on soil physical properties. [less ▲]

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See detailFalse positive PTH results: An easy strategy to test and detect analytical interferences in routine practice
Cavalier, Etienne ULg; Carlisi, Agnès; Chapelle, Jean-Paul ULg et al

in Clinica Chimica Acta (2008), 387(1-2), 150-152

Background: As other immunoassays, PTH determination is not free from interferences. Indeed, natural antibodies like heterophile antibodies (HAMA) and rheumatoid factor (RF) can induce falsely elevated ... [more ▼]

Background: As other immunoassays, PTH determination is not free from interferences. Indeed, natural antibodies like heterophile antibodies (HAMA) and rheumatoid factor (RF) can induce falsely elevated results, leading to misdiagnosis and expensive unnecessary explorations. However, in routine practice, these interferences are not always obvious to detect. Methods: On 2084 PTH samples, we applied a validation strategy in four steps to screen for HAMA and rheumatoid factor interferences. Results: 36% of our samples presented an elevated PTH. We found a clinically plausible reason for 91% of them. The remaining 63 suspicious samples were treated with HBT and 40% of them were found to be HAMA positive. RF determination was performed on the HAMA-negative samples and RE was positive in 21 of them. They were then treated with RF-Absorbent. Nine of these 21 samples presented RE interference. Conclusion: Applying this strategy in our routine validation, we managed to avoid spuriously elevated PTH results, which could have caused medical errors as well as unnecessary cost-effective extra-investigations. (c) 2007 Elsevier B.V. All rights reserved. [less ▲]

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See detailXMM-Newton X-ray study of early type stars in the Carina OB1 association
Antokhin, I. I.; Rauw, Grégor ULg; Vreux, Jean-Marie ULg et al

in Astronomy and Astrophysics (2008), 477(2), 593-609

Aims. X-ray properties of the stellar population in the Carina OB I association are examined with special emphasis on early-type stars. Their spectral characteristics provide some clues to understanding ... [more ▼]

Aims. X-ray properties of the stellar population in the Carina OB I association are examined with special emphasis on early-type stars. Their spectral characteristics provide some clues to understanding the nature of X-ray formation mechanisms in the winds of single and binary early-type stars. Methods. A timing and spectral analysis of five observations with XMM-Newton is performed using various statistical tests and thermal spectral models. Results. 235 point sources have been detected within the field of view. Several of these sources are probably pre-main sequence stars with characteristic short-term variability. Seven sources are possible background AGNs. Spectral analysis of twenty four sources of type OB and WR 25 was performed. We derived spectral parameters of the sources and their fluxes in three energy bands. Estimating the interstellar absorption for every source and the distance to the nebula, we derived X-ray luminosities of these stars and compared them to their bolometric luminosities. We discuss possible reasons for the fact that, on average, the observed X-ray properties of binary and single early type stars are not very different, and give several possible explanations. [less ▲]

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See detailThe combined immunodetection of AP-2alpha and YY1 transcription factors is associated with ERBB2 gene overexpression in primary breast tumors.
Allouche, Abdelkader; Nolens, Gregory ULg; Tancredi, Annalisa ULg et al

in Breast Cancer Research [=BCR] (2008), 10(1), 9

INTRODUCTION: Overexpression of the ERBB2 oncogene is observed in about 20% of human breast tumors and is the consequence of increased transcription rates frequently associated with gene amplification ... [more ▼]

INTRODUCTION: Overexpression of the ERBB2 oncogene is observed in about 20% of human breast tumors and is the consequence of increased transcription rates frequently associated with gene amplification. Several studies have shown a link between activator protein 2 (AP-2) transcription factors and ERBB2 gene expression in breast cancer cell lines. Moreover, the Yin Yang 1 (YY1) transcription factor has been shown to stimulate AP-2 transcriptional activity on the ERBB2 promoter in vitro. In this report, we examined the relationships between ERBB2, AP-2alpha, and YY1 both in breast cancer tissue specimens and in a mammary cancer cell line. METHODS: ERBB2, AP-2alpha, and YY1 protein levels were analyzed by immunohistochemistry in a panel of 55 primary breast tumors. ERBB2 gene amplification status was determined by fluorescent in situ hybridization. Correlations were evaluated by a chi2 test at a p value of less than 0.05. The functional role of AP-2alpha and YY1 on ERBB2 gene expression was analyzed by small interfering RNA (siRNA) transfection in the BT-474 mammary cancer cell line followed by real-time reverse transcription-polymerase chain reaction and Western blotting. RESULTS: We observed a statistically significant correlation between ERBB2 and AP-2alpha levels in the tumors (p < 0.01). Moreover, associations were found between ERBB2 protein level and the combined high expression of AP-2alpha and YY1 (p < 0.02) as well as between the expression of AP-2alpha and YY1 (p < 0.001). Furthermore, the levels of both AP-2alpha and YY1 proteins were inversely correlated to ERBB2 gene amplification status in the tumors (p < 0.01). Transfection of siRNAs targeting AP-2alpha and AP-2gamma mRNAs in the BT-474 breast cancer cell line repressed the expression of the endogenous ERBB2 gene at both the mRNA and protein levels. Moreover, the additional transfection of an siRNA directed against the YY1 transcript further reduced the ERBB2 protein level, suggesting that AP-2 and YY1 transcription factors cooperate to stimulate the transcription of the ERBB2 gene. CONCLUSION: This study highlights the role of both AP-2alpha and YY1 transcription factors in ERBB2 oncogene overexpression in breast tumors. Our results also suggest that high ERBB2 expression may result either from gene amplification or from increased transcription factor levels. [less ▲]

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See detailSynopsis des chapitres de l'ouvrage Écologisation
Melard, François ULg

in Melard, François (Ed.) Écologisation : Objets et concepts intermédiaires (2008)

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See detailOptimal dimensioning of pipe networks: the new situation when the distribution and the transportation functions are disconnected
Bakhouya, Bouchra; de Wolf, Daniel ULg

Conference (2008, January)

In [9], De Wolf and Smeers consider the problem of the optimal dimensioning of a gas transmission network when the topology of the network is known. The pipe diameters must been chosen to minimize the sum ... [more ▼]

In [9], De Wolf and Smeers consider the problem of the optimal dimensioning of a gas transmission network when the topology of the network is known. The pipe diameters must been chosen to minimize the sum of the investment and operating costs. This two stage prob- lem was solved by application of the bundle method for nonsmooth optimization. This model does not re ect any more the current situation on the gas industry. Today, the transportation function and gas buying func- tion are separated. This work considers the new situation for the trans- portation company. The objective for the transportation company is to determine the ows in the network that minimize the energy used for the gas transport. This corresponds to the minimization of the power used in the compressors. We introduce in the investment problem new decision variables, namely the maximal power of the compressor. We present here rst results obtained on the belgian gas network and on a realistic network corresponding to a part of the french network. [less ▲]

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See detailLe service social sous le regard du genre
Cornet, Annie ULg

in Politiques sociales (2008), 1-2

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See detailScreening for inter-hospital differences in cesaezan section rates in low-risk deliveries using administrative data: an initiative to improve the quality of care.
Aelvoet, Willem; Windey, Francis; Molenberghs, Geert et al

in BMC Health Services Research (2008), 4(8), 3

BACKGROUND: Rising national cesarean section rates (CSRs) and unexplained inter-hospital differences in CSRs, led national and international bodies to select CSR as a quality indicator. Using hospital ... [more ▼]

BACKGROUND: Rising national cesarean section rates (CSRs) and unexplained inter-hospital differences in CSRs, led national and international bodies to select CSR as a quality indicator. Using hospital discharge abstracts, we aimed to document in Belgium (1) inter-hospital differences in CSRs among low risk deliveries, (2) a national upward CSR trend, (3) lack of better neonatal outcomes in hospitals with high CSRs, and (4) possible under-use of CS. METHODS: We defined a population of low risk deliveries (singleton, vertex, full-term, live born, <4500 g, >2499 g). Using multivariable logistic regression techniques, we provided degrees of evidence regarding the observed departure ([relative risk-1]*100) of each hospital (N = 107) from the national CSR and its trend. To determine a benchmark, we defined three CSR groups (high, average and low) and compared them regarding 1 minute Apgar scores and other neonatal endpoints. An anonymous feedback is provided to the hospitals, the College of Physicians (with voluntary disclosure of the outlying hospitals for quality improvement purposes) and to the policy makers. RESULTS: Compared with available information, the completeness and accuracy of the data, regarding the variables selected to determine our study population, showed adequate. Important inter-hospital differences were found. Departures ranged from -65% up to +75%, and 9 "high CSR" and 13 "low CSR" outlying hospitals were identified. We observed a national increasing trend of 1.019 (95%CI [1.015; 1.022]) per semester, adjusted for age groups. In the "high CSR" group 1 minute Apgar scores <4 were over-represented in the subgroup of vaginal deliveries, suggesting CSs not carried out for medical reasons. Under-use of CS was also observed. Given their questionable completeness, except Apgar scores, our neonatal results, showing a significant association of CS with adverse neonatal endpoints, are to be cautiously interpreted. Taking the available evidence into account, the "Average CSR" group seemed to be the best benchmark candidate. CONCLUSION: Rather than firm statements about quality of care, our results are to be considered a useful screening. The inter-hospital differences in CSR, the national CS upward trend, the indications of over-use and under-use, the geographically different obstetric patterns and the admission day-related concentration of deliveries, whether or not by CS, may trigger initiatives aiming at improving quality of care. [less ▲]

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See detailPALETTE : Extensions of O'CoP Ontology
Dieng-Kuntz, Rose; Denis, Brigitte ULg; El Ghali, Adil et al

Report (2008)

This deliverable first analyzes some integration problems encountered during the integration of the O’CoP ontology that was developed by several ontologists. Then, we describe several experiments of ... [more ▼]

This deliverable first analyzes some integration problems encountered during the integration of the O’CoP ontology that was developed by several ontologists. Then, we describe several experiments of development of CoP-specific ontologies · Natural Language processing (NLP) tools were used by Knowledge Management (KM) service developers for analyzing a corpus of e-mails of the @pretic CoP, so as to develop a “Technical Problem” ontology. We also reused an existing hierarchy in order to build the Ontopedia ontology. Last, the development of the ontologies “Human Problems” and “Learning and Teaching” for the @pretic CoP relied on brainstormings between the CoP mediator and the CoP members. · For the Form@Hetice CoP, the ontology was aimed at being used by the BayFac system offering service of document classification, and was developed by the service developers, with a validation by the Form@Hetice CoP mediator. · For Learn-Nett CoP, the ontology was also aimed at being used by the BayFac system, and was developed by the service developers and the CoP mediator (who was also a member of the CoP), with a continuous validation by a CoP focus group. · For the TFT CoP, tbe ontology was developed manually by the CoP mediator through a folksonomy obtained using tags on the CoP documents, according to social tagging approach. At the end of the deliverable, we compare these different ontologies with related work and we analyze them from reusability viewpoint [less ▲]

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See detailEvaluation of traffic polluting gases emissions using OR techniques: the case of the city of Tunis
Guirat, Noomen; de Wolf, Daniel ULg

Conference (2008, January)

The purpose of this paper is to show how the operations research techniques can help to evaluate the emissions of polluting gases from road traffic in urban area. Our practical study case is the center of ... [more ▼]

The purpose of this paper is to show how the operations research techniques can help to evaluate the emissions of polluting gases from road traffic in urban area. Our practical study case is the center of Tunis city. To evaluate the emissions of several polluting gases (CO, CO2, SO2, NOx, CH4 and VOC), we have combined the traffic assignment model ATESAME [1] with new module implementing the CORINAIR [2] formulas. The traffic assignment model corresponds to a static User Equilibrium model that can be computed by solving a nonlinear optimization problem (See Sheffi [5]). This nonlinear convex model can be efficiently solved by using the classical Frank Wolfe technique. The CORINAIR formulas give an expression of the unitary emissions, i.e. the emissions per kilometer, as a function of the vehicle speed and of the current temperature. Several scenarios of traffic congestion and emperature conditions have been simulated for the center of Tunis City. We present here the mains results from the simulations for the center of Tunis city. [less ▲]

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See detailSteel thixoforming, influence of forming parameters on the microstructure
Pierret, Jean-Christophe ULg; Rassili, Ahmed ULg; Vaneetveld, Grégory ULg et al

in International Journal of Material Forming (2008), 1(1), 1011-1014

Forming of parts in the semi-solid state is quite a complex process, especially for high melting point alloys such as steel. A reason for this complexity is the amount of parameters involved in the ... [more ▼]

Forming of parts in the semi-solid state is quite a complex process, especially for high melting point alloys such as steel. A reason for this complexity is the amount of parameters involved in the process. Among these we could quote liquid fraction, shear rate, shape factor, contiguity, tool temperature, agglomeration level, heating rate, protecting gas, temperature distribution, lubricant. Of course all of these parameters don’t have the same order of importance. In this paper we show the influence of a set of chosen parameters and we highlight their effects on the microstructure and so, on the deformation behavior. The studied parameters are the heating conditions, the tool temperature, the part temperature, the thermal exchanges between the part and the dies and the forming rate. [less ▲]

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See detailVariations on leptogenesis
Aristizabal Sierra, Diego ULg; Losada, Marta; Enrico, Nardi

in Physics Letters B (2008), 659

We study variations of the standard leptogenesis scenario that can arise if an additional mass scale related to the breaking of some new symmetry (as for example a flavor or the B–L symmetry) is present ... [more ▼]

We study variations of the standard leptogenesis scenario that can arise if an additional mass scale related to the breaking of some new symmetry (as for example a flavor or the B–L symmetry) is present below the mass MN1 of the lightest right-handed Majorana neutrino. Our scheme is inspired by U(1) models of flavor à la Froggatt–Nielsen, and involves new vectorlike heavy fields F. We show that depending on the specific hierarchy between MN1 and the mass scale of the fields F, qualitatively different realizations of leptogenesis can emerge. We compute the CP asymmetries in N1 decays in all the relevant cases, and we conclude that in most situations leptogenesis could be viable at scales much lower than in the standard scenario. [less ▲]

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