Publications ORBi OA
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See detailDevelopment and pre-validation of a high sensitive method for the determination of levonorgestrel in human plasma by SPE/LC/MS-MS
Hubert, Cédric ULg; streel, Bruno; Sibenaler, Renilde et al

Poster (2007, July)

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See detailEvaluation of the efficacy and safety of etoricoxib compared with naproxen in two, 138-week randomised studies of patients with osteoarthritis
Reginster, Jean-Yves ULg; Malmstrom, K.; Mehta, A. et al

in Annals of the Rheumatic Diseases (2007), 66(7), 945-951

Objectives: To assess the efficacy and safety of etoricoxib 60 mg once daily and naproxen 500 mg twice daily over a 138- week treatment period in patients with osteoarthritis ( OA). Methods: Two 1- year ... [more ▼]

Objectives: To assess the efficacy and safety of etoricoxib 60 mg once daily and naproxen 500 mg twice daily over a 138- week treatment period in patients with osteoarthritis ( OA). Methods: Two 1- year randomised, double blind, parallel group two- part base studies ( part I 12 weeks; part II 40 weeks), followed by an 86- week extension, in patients with OA ( hip or knee) were conducted at 80 clinical centres ( 19 countries). The studies had identical designs. Patients taking placebo in part I received etoricoxib or naproxen ( 1: 1 ratio) in part II and the extension; patients taking etoricoxib or naproxen in part I continued to receive the same treatment throughout the entire length of the studies. Co- primary efficacy end points were patient global assessment of disease status, and WOMAC questionnaire pain subscale and physical function subscale ( 100 mm VAS). Efficacy over 138 weeks was assessed by graphical analysis. Safety was assessed by observation of adverse experiences and laboratory and physical evaluations. Results: 997 patients entered ( 615 completed) the base studies. Of these patients, 463 patients entered the extensions. A total of 161 and 152 patients in the etoricoxib and naproxen groups, respectively, completed 138 treatment weeks. Etoricoxib and naproxen showed similar efficacy throughout the 138 weeks of treatment. For etoricoxib and naproxen, respectively, WOMAC pain assessments were 67 and 67 mm ( baseline); 28 and 29 mm ( 1 year), and 34 and 33 mm ( 138 weeks). Results for the other efficacy end points were similar to those seen with the WOMAC pain assessments. Both etoricoxib and naproxen were generally well tolerated. Conclusion: Both etoricoxib and naproxen demonstrated long- term clinical efficacy for the treatment of OA. Etoricoxib and naproxen were generally well tolerated. [less ▲]

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See detailPaul Jaspar, photographe du patrimoine
Charlier, Sébastien ULg

in Nouvelles du Patrimoine (Les) (2007), 117

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See detailPerception of dyspnea in mild smoking asthmatics
Kleis, S.; Chanez, P.; Delvaux, Muriel ULg et al

in Respiratory Medicine (2007), 101(7), 1426-1430

Background: Previous data from the literature reported blunted perception of airway obstruction in severe asthmatics with near fatal asthma. Approximately 25% of patients with asthma are current smokers ... [more ▼]

Background: Previous data from the literature reported blunted perception of airway obstruction in severe asthmatics with near fatal asthma. Approximately 25% of patients with asthma are current smokers. Aim: To determine whether there is an alteration in perception of airway obstruction during a non specific provocative challenge with methacholine in mild controlled asthmatics who smoke. Methods: Enrolled in this study were 50 subjects, including 26 mild asthmatics and 24 healthy subjects, all of them current smokers. The first objective was the sensitivity of airway obstruction calculated by the regression slope linking the change in the visual analogic scale (VAS) assessed by the patient and the fall in FEV1 during a methacholine challenge. Results: Asthmatics who smoke had a blunted perception of airway obstruction during the bronchial challenge significantly different from that seen in healthy smokers (p = 0.03). This impaired dyspnea perception was inversely related to baseline VAS (r = -0.29, p<0.05) and positively related to baseline FEV1 (r = 0.35, p<0.05). Perception of airway obstruction was not correlated with age, sex, atopy or with airway inflammation features such as exhaled NO or sputum eosinophils. Conclusion: Mild asthmatics who smoke display reduced dyspnea perception during a nonspecific provocative challenge with methacholine. This altered perception of airway obstruction does not relate to airway inflammation. (C) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailFrançais: le niveau baisse-t-il? Maîtrise de la langue maternelle et études supérieures
Defays, Jean-Marc ULg

in Science and Culture (2007), 408

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See detailBenefits of Physical Training in Fibromyalgia and Related Syndromes
Maquet, Didier ULg; Demoulin, Christophe ULg; Croisier, Jean-Louis ULg et al

in Annales de Réadaptation et de Médecine Physique (2007), 50(6), 363-368

OBJECTIVE: To review the published information on physical training for fibromyalgia (FM) and related syndromes. METHODS: A search of Medline literature (via Ovid and PubMed) with the following keywords ... [more ▼]

OBJECTIVE: To review the published information on physical training for fibromyalgia (FM) and related syndromes. METHODS: A search of Medline literature (via Ovid and PubMed) with the following keywords: FM, chronic fatigue syndrome, therapy, rehabilitation, aerobic, exercise, and cognitive behavioral therapy. The reference lists of articles were examined for additional related articles. RESULTS: Several studies investigated the benefits of graded exercise therapy for patients with FM or related syndromes. Although some systematic reviews have not established an unequivocal benefit of physical training, most authors report a benefit for patients with chronic pain or fatigue. Ideally, such a therapy should be a part of multidisciplinary program. Muscular rehabilitation is reserved for preventing the deconditioning syndrome often reported in patients and the vicious cycle of pain, avoidance and inactivity behaviors, or even kinesiophobia, deconditioning, incapacity and psychological distress. CONCLUSION: This review emphasizes the relevance of graded physical training for treating FM and related syndromes. The development of rehabilitation centers, with experts able to propose a relevant therapy to patients with chronic pain or fatigue, should help alleviate this public health problem. [less ▲]

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See detailComparison of learning curves and skill transfer between classical and robotic laparoscopy according to the viewing conditions: implications for training
Blavier, Adelaïde ULg; Gaudissart, Quentin; Cadière, Guy-Bernard et al

in American Journal of Surgery (2007), 194(1), 115-121

BACKGROUND: The purpose of this study was to evaluate the perceptual (2-dimensional [2D] vs. 3-dimensional [3D] view) and instrumental (classical vs. robotic) impacts of new robotic system on learning ... [more ▼]

BACKGROUND: The purpose of this study was to evaluate the perceptual (2-dimensional [2D] vs. 3-dimensional [3D] view) and instrumental (classical vs. robotic) impacts of new robotic system on learning curves. METHODS: Forty medical students without any surgical experience were randomized into 4 groups (classical laparoscopy with 3D-direct view or with 2D-indirect view, robotic system in 3D or in 2D) and repeated a laparoscopic task 6 times. After these 6 repetitions, they performed 2 trials with the same technique but in the other viewing condition (perceptive switch). Finally, subjects performed the last 3 trials with the technique they never used (technical switch). Subjects evaluated their performance answering a questionnaire (impressions of mastery, familiarity, satisfaction, self-confidence, and difficulty). RESULTS: Our study showed better performance and improvement in 3D view than in 2D view whatever the instrumental aspect. Participants reported less mastery, familiarity, and self-confidence and more difficulty in classical laparoscopy with 2D-indirect view than in the other conditions. CONCLUSIONS: Robotic surgery improves surgical performance and learning, particularly by 3D view advantage. However, perceptive and technical switches emphasize the need to adapt and pursue training also with traditional technology to prevent risks in conversion procedure. [less ▲]

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See detailConsultations in molecular diagnostics - A case of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia with a rare FIP1L1 breakpoint
Lambert, Frédéric ULg; Heimann, Pierre; Herens, Christian ULg et al

in Journal of Molecular Diagnostics (2007), 9(3), 414-419

The idiopathic hypereosinophilic syndrome (HES) has remained for a long time a diagnosis of exclusion. Differential diagnosis between the HES and the related chronic eosinophilic leukemia (CEL) relied on ... [more ▼]

The idiopathic hypereosinophilic syndrome (HES) has remained for a long time a diagnosis of exclusion. Differential diagnosis between the HES and the related chronic eosinophilic leukemia (CEL) relied on the identification of signs of clonality that allowed, when present, the reclassification of patients as CEL. Recently, a new acquired mutation was described in approximately 50% of the HES/CEL patients: a cryptic deletion on chromosome band 4q12 generating a FIP1IL1-PDGFRA fusion gene. According to the World Health Organization classification, this clonal abnormality has been proposed as a new surrogate marker for chronic eosinophilic leukemia diagnosis. Fluorescence in situ hybridization and reverse transcriptase-polymerase chain reaction protocols were developed for an accurate del(4)(q12q12) and FIP1L1-PDGFRA fusion gene detection. Here, we report a patient with a rare FIP1L1 intron 16 breakpoint located outside of the reported FIP1L1 breakpoint region (ie, from FIP1L1 introns 9 to 13). This case illustrates the risk of false-negative results with diagnostic procedures that do not take into account the occurrence of rare FIP1L1 breakpoints. As targeted therapy with tyrosine kinase inhibitors has dramatically changed the prognosis of FIP1L1-PDGFRA (+) CEL, false-negative results could hamper accurate diagnosis and treatment. [less ▲]

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See detailEarly inflammation in the airways of a cystic fibrosis foetus
Verhaeghe, C.; Delbecque, Katty ULg; de Leval, Laurence ULg et al

in Journal of Cystic Fibrosis (2007), 6(4), 304-308

In cystic fibrosis patients, inflammation is often considered to be secondary to chronic infections. In the present study, we show increased levels of pro-inflammatory proteins in the lungs of a cystic ... [more ▼]

In cystic fibrosis patients, inflammation is often considered to be secondary to chronic infections. In the present study, we show increased levels of pro-inflammatory proteins in the lungs of a cystic fibrosis foetus compared to the lungs of two normal foetuses. Our findings suggest therefore the existence of an early intrinsic pro-inflammatory state in cystic fibrosis airways. (C) 2006 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. [less ▲]

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See detailIntérêts du réentraînement à l'effort dans la fibromyalgie et autres syndromes apparentés
Maquet, Didier ULg; Demoulin, Christophe ULg; Croisier, Jean-Louis ULg et al

in Annales de Réadaptation et de Médecine Physique (2007), 50(6), 356-362

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See detailModel-based cardiac diagnosis of pulmonary embolism
Starfinger, C.; Hann, C. E.; Chase, J. G. et al

in Computer Methods & Programs in Biomedicine (2007), 87(1), 46-60

A minimal cardiac model has been shown to accurately capture a wide range of cardiovascular system dynamics commonly seen in the intensive care unit (ICU). However, standard parameter identification ... [more ▼]

A minimal cardiac model has been shown to accurately capture a wide range of cardiovascular system dynamics commonly seen in the intensive care unit (ICU). However, standard parameter identification methods for this model are highly non-linear and non-convex, hindering real-time clinical application. An integral-based identification method that transforms the problem into a linear, convex problem, has been previously developed, but was only applied on continuous simulated data with random noise. This paper extends the method to handle discrete sets of clinical data, unmodelled dynamics, a significantly reduced data set theta requires only the minimum and maximum values of the pressure in the aorta, pulmonary artery and the volumes in the ventricles. The importance of integrals in the formulation for noise reduction is illustrated by demonstrating instability in the identification using simple derivative-based approaches. The cardiovascular system (CVS) model and parameter identification method are then clinically validated on porcine data for pulmonary embolism. Errors for the identified model are within 10% when re-simulated and compared to clinical data. All identified parameter trends match clinically expected changes. This work represents the first clinical validation of these models, methods and approach to cardiovascular diagnosis in critical care. (c) 2007 Elsevier Ireland Ltd. All rights reserved. [less ▲]

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See detailOptimization of encoding specificity for the diagnosis of early AD: The RI-48 task
Adam, Stéphane ULg; Van der Linden, Martial ULg; Ivanoiu, A. et al

in Journal of Clinical and Experimental Neuropsychology (2007), 29(5), 477-487

The aim of this study was to evaluate the discriminant validity of the RI-48 test, a shorter French version of the Category Cued Recall portion of the Double Memory Test developed initially by Buschke and ... [more ▼]

The aim of this study was to evaluate the discriminant validity of the RI-48 test, a shorter French version of the Category Cued Recall portion of the Double Memory Test developed initially by Buschke and colleagues (1997), in the diagnosis of mild and very mild Alzheimer disease (AD). The distinctive feature of the RI-48 task is that encoding specificity was increased by adding an immediate cued recall stage at the encoding phase. The results show that the RI-48 task seems to be well adapted to the clinical context and to have good psychometric properties, in particular a lack of a ceiling effect. Moreover, this task appears to be especially well suited for the diagnosis of both mild and very mild AD (sensitivity of 93% and 83.8%). From a more theoretical point of view, this study confirms the importance of optimizing the encoding specificity for the diagnosis of very mild AD, since the more encoding specificity is accentuated, the more discriminating power is increased for the diagnosis of very mild AD. [less ▲]

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See detailProviding stability maps for milling operations
Le Lan, Jean-Vincent; Marty, Audrey; Debongnie, Jean-François ULg

in International Journal of Machine Tools & Manufacture (2007), 47(9), 1493-1496

This article presents a new stability prediction tool. The method is based on the dynamic behaviour of both milling tool and workpiece, computed using finite element method. Dynamic behaviour is expressed ... [more ▼]

This article presents a new stability prediction tool. The method is based on the dynamic behaviour of both milling tool and workpiece, computed using finite element method. Dynamic behaviour is expressed under the form of transfer functions and used to predict stability lobes at each tool position. The unconditionally stable depth of cut is then stored and displayed on a graphic representation of the machined surface under the form of colour axis, named stability map. An application of the method on a Renault cylinder block is presented as an illustration. (C) 2006 Elsevier Ltd. All rights reserved. [less ▲]

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See detailControl of phase shifting transformers by multiple transmission system operators
Marinakis, Adamantios ULg; Glavic, Mevludin; Van Cutsem, Thierry ULg

(2007, July)

A general framework is proposed for the control of phase shifting transformers owned by several TSOs, taking into account their interactions. The proposed solution is the Nash equilibrium of a sequence of ... [more ▼]

A general framework is proposed for the control of phase shifting transformers owned by several TSOs, taking into account their interactions. The proposed solution is the Nash equilibrium of a sequence of optimizations performed by the various TSOs, each of them taking into account the other TSOs’ control settings as well as operating constraints relative to the whole system. The method is applied to a linearized network model and illustrated on the IEEE 118-bus system. [less ▲]

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See detailEmergency alleviation of thermal overloads using model predictive control
Otomega, Bogdan; Marinakis, Adamantios ULg; Glavic, Mevludin et al

(2007, July)

An approach inspired of Model Predictive Control is proposed to determine a sequence of control actions aimed at alleviating thermal overloads in emergency conditions. The algorithm brings the line ... [more ▼]

An approach inspired of Model Predictive Control is proposed to determine a sequence of control actions aimed at alleviating thermal overloads in emergency conditions. The algorithm brings the line currents below their limits in the time interval left by protections, while accounting for constraints on control changes at each step. Its closed-loop nature allows to compensate for measurement noise and model uncertainties. [less ▲]

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See detailHeterogeneous alkenylation of aromatics under oxygen
Hajek, Jan; Dams, Mieke; Detrembleur, Christophe ULg et al

in Catalysis Communications (2007), 8(7), 1047-1051

A novel heterogeneous Pd/polymer catalyst containing co-catalytic functional groups catalyses the direct alkenylation of anisole with ethyl trans-cinnamate under oxygen. The properties of the polymeric ... [more ▼]

A novel heterogeneous Pd/polymer catalyst containing co-catalytic functional groups catalyses the direct alkenylation of anisole with ethyl trans-cinnamate under oxygen. The properties of the polymeric catalyst were compared to other immobilised catalysts. The activity of the polymeric catalyst typically increased with temperature and oxygen pressure exhibiting the optimal activity up to 100 TON at 383 K under 1.2 MPa of O-2. The most abundant product was 3-(p-methoxyphenyl)-3-phenylpropanoate (approximate to 45%). The reaction selectivity was practically independent of the conditions. Split-tests and AAS measurements confirm heterogeneous character of the catalyst. [less ▲]

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See detailCreative Industries, governmentalities and heterotopias: the case of local government in France
Froehlicher, Thomas ULg; Guillemin, Arnaud; Apangu, Patricia

Conference (2007, July)

Creative industries, since 1997, have become assets for economic and cultural development. Nations around the world, at different political levels, are now focusing on the development of a creative ... [more ▼]

Creative industries, since 1997, have become assets for economic and cultural development. Nations around the world, at different political levels, are now focusing on the development of a creative industries policy. The success of this concept can be linked to the fact that this meta-sector has one of the highest levels of economic growth in these last years. Despite the growing number of studies on creative industries, the rationale behind the implementation of this type of policy remains unclear. We seek to further understand how and why local governments are participating in creative industries and how it is spatially acted, by using the concepts of governmentality and heterotopias, as defined by Foucault (1991a, 1997), to explore the rationality and the dynamics behind this policy. Our study focuses on the case of the “Grand Lyon” and its economic development agency. In early 2006, Lyon decided to launch a creative industries policy focused on its two existing creative clusters linked to fashion and video games, Lyon Vision Mode and Lyon Game respectively. A transversal approach was taken to include various and often unconnected sectors. Lyon is the third largest French city with a strong industrial economy. The city has the ambition to be in the top fifteen of the creative regions in Europe. Our results demonstrate that, first of all, the practices of creative industries highlight the different types of technologies that were expressing the rationality and mentality of the ‘governors’. We also found that the policy deployed by the local government created two types of heterotopias (Foucault, 1997). These separate and different spaces appeared as places for creativity in the development and implementation of the creative industries strategy. These heterotopias help to build a sense of community among the participants, and create a tribe, clan, or as defined by Florida (2002), a class. [less ▲]

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See detailRetour sur le "secteur informel". L'économie du Katanga (Congo-Zaïre) face à la falsification de la loi
Rubbers, Benjamin ULg

in Sociologie du Travail (2007), 49(3), 316-329

In the social sciences, the idea of an informal sector has been criticized more for the classification of economic activities in two separate sectors than for the labeling of them as 'formal' or 'informal ... [more ▼]

In the social sciences, the idea of an informal sector has been criticized more for the classification of economic activities in two separate sectors than for the labeling of them as 'formal' or 'informal'. In the Congo (formerly Zaire), the use of such labels is ambiguous. Labeling has to be understood in the context of corruption, i.e. in a transaction involving the personal networks and social identities of the parties in it. An analysis is made of how such transactions which civil servants shape the local market in the case of the import trade in Katanga. Compared to the formal/informal cleavage, this approach enables us both to see the labeling of economic activities as a social and political process and to draw attention to the plurality of such practices in relations with authorities. [less ▲]

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See detailProposition pour la mise en oeuvre des priorités relatives à la coopération interuniversitaire approuvées lors du XIXe Sommet des Exécutifs de la Grande Région
Halleux, Isabelle ULg; Petit, Patricia ULg

Report (2007)

The aim of this study is to propose specific actions for a long-term efficient and self-supporting cooperation between universities of the Great Region (Sarre, Lorraine, Luxembourg, Rhenanie-Palatinat and ... [more ▼]

The aim of this study is to propose specific actions for a long-term efficient and self-supporting cooperation between universities of the Great Region (Sarre, Lorraine, Luxembourg, Rhenanie-Palatinat and Wallonia) [less ▲]

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See detailModeling of 3-D losses and deviations in a throughflow analysis tool
Simon, Jean-Francois; Nicks, Alain; Paris, Nicolas et al

in Proceedings of the 8th International Symposium for Experimental and Computational Aerothermodynamics of Internal Flow (2007, July)

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