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See detailEquivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: The NESTOR* study
Marre, Michel; Garcia Puig, Juan; Kokot, Franciszek et al

in Journal of Hypertension (2004), 22(8), 1613-1622

Objectives To test whether microalbuminuria in patients with type 2 diabetes and hypertension is primarily dependent on the severity of hypertension, and to compare the effectiveness of two anti ... [more ▼]

Objectives To test whether microalbuminuria in patients with type 2 diabetes and hypertension is primarily dependent on the severity of hypertension, and to compare the effectiveness of two anti hypertensive drugs with opposite effects on the renin-angiotensin system [the diuretic, indapamide sustained release (SR), and an angiotensin-converting enzyme inhibitor, enalapril] in reducing microalbuminuria. Design A multinational, multicentre, controlled, double-blind, double-dummy, randomized, two-parallel-groups study over 1 year. Methods After a 4-week placebo run-in period, 570 patients (ages 60.0 +/- 9.9 years, 64% men) with type 2 diabetes, essential hypertension [systolic blood pressure (SBP) 140-180 mmHg, and diastolic blood pressure (DBP) < 110 mmHg], and persistent microalbuminuria (20-200 mu g/min) were allocated randomly to groups to receive indapamide SR 1.5 mg (n = 284) or enalapril 10 mg (n = 286) once a day. Amlodipine, atenolol, or both were added, if necessary, to achieve the target blood pressure of 140/85 mmHg. Results There was a significant reduction in the urinary albumin: creatinine ratio. Mean reductions were 35% [95% confidence interval (Cl) 24 to 43] and 39% (95% Cl 30 to 47%) in the indapamide SR and enalapril groups, respectively. Equivalence was demonstrated between the two groups [1.08 (95% Cl 0.89 to 1.31%); P = 0.01]. The reductions in mean arterial pressure (MAP) were 16.6 +/- 9.0 mmHg for the indapamide SR group and 15.0 +/- 9.1 mmHg for the enalapril group (NS); the reduction in SBP was significantly greater (P = 0.0245) with indapamide SR. More than 50% of patients in each group required additional antihypertensive therapy, with no differences between groups. Both treatments were well tolerated. Conclusions lndapamide-SR-based therapy is equivalent to enalapril-based therapy in reducing microalbuminuria with effective blood pressure reduction in patients with hypertension and type 2 diabetes. [less ▲]

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See detailFluorinated tracers for imaging cancer with positron emission tomography
Couturier, Olivier; Luxen, André ULg; Chatal, Jean-François et al

in European Journal of Nuclear Medicine and Molecular Imaging (2004), 31(8), 1182-1206

2-[F-18]fluoro-2-deoxy-D-glucose (FDG) is currently the only fluorinated tracer used in routine clinical positron emission tomography (PET). Fluorine-18 is considered the ideal radioisotope for PET ... [more ▼]

2-[F-18]fluoro-2-deoxy-D-glucose (FDG) is currently the only fluorinated tracer used in routine clinical positron emission tomography (PET). Fluorine-18 is considered the ideal radioisotope for PET imaging owing to the low positron energy (0.64 MeV), which not only limits the dose rate to the patient but also results in a relatively short range of emission in tissue, thereby providing high-resolution images. Further, the 110-min physical half-life allows for high-yield radiosynthesis, transport from the production site to the imaging site and imaging protocols that may span hours, which permits dynamic studies and assessment of potentially fairly slow metabolic processes. The synthesis of fluorinated tracers as an alternative to FDG was initially tested using nucleophilic fluorination of the molecule, as performed when radiolabelling with iodine-124 or bromide-76. However, in addition to being long, with multiple steps, this procedure is not recommended for bioactive molecules containing reactive groups such as amine or thiol groups. Radiochemical yields are also often low. More recently, radiosynthesis from prosthetic group precursors, which allows easier radiolabelling of biomolecules, has led to the development of numerous fluorinated tracers. Given the wide availability of 18F, such tracers may well develop into important routine tracers. This article is a review of the literature concerning fluorinated radiotracers recently developed and under investigation for possible PET imaging in cancer patients. Two groups can be distinguished. The first includes "generalist" tracers, i.e. tracers amenable to use in a wide variety of tumours and indications, very similar in this respect to FDG. These are tracers for non-specific cell metabolism, such as protein synthesis, amino acid transport, nucleic acid synthesis or membrane component synthesis. The second group consists of "specific" tracers for receptor expression (i.e. oestrogens or somatostatin), cell hypoxia or bone metabolism. [less ▲]

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See detailPotentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha (vol 23, pg 6200, 2003)
Adam, Emmanuelle; Quivy, Vincent; Bex, Françoise et al

in Molecular and Cellular Biology (2004), 24(15), 6890

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See detailThe XMM-LSS survey - First high redshift galaxy clusters: Relaxed and collapsing systems
Valtchanov, I.; Pierre, M.; Willis, J. et al

in Astronomy and Astrophysics (2004), 423(1), 75-85

We present five newly found galaxy clusters at z > 0.6 from the XMM Large-Scale Structure Survey (XMM-LSS). All five objects are extended X-ray sources in the XMM images. For three of them we have ... [more ▼]

We present five newly found galaxy clusters at z > 0.6 from the XMM Large-Scale Structure Survey (XMM-LSS). All five objects are extended X-ray sources in the XMM images. For three of them we have sufficient spectroscopically confirmed member galaxies that an estimate of the velocity dispersion is possible: XLSSC 001 at z = 0.613 and sigma(nu) = 867(-60)(+80) km s(-1), XLSSC 002 at z = 0.772 and sigma(nu) = 524(-116)(+267) km s(-1) and XLSSC 003 at z = 0.839 and sigma(V) = 780(-75)(+137) km s(-1). These three clusters have X-ray bolometric luminosities L-X similar to 1-3 x 10(44) erg s(-1) and temperatures 2-4 keV, and consequently are less massive than previously known clusters at similar redshifts, but nevertheless they follow the low redshift scaling relations between L-X, T and sigma(upsilon), within the limits of the measurement errors. One of the clusters, XLSSC 004, is detected independently as an over-density of galaxies of a colour R - z' = 1.4 that matches the redshift of the central galaxy z = 0.87, although it cannot unambiguously be confirmed by the spectroscopic observations alone. The highest redshift candidate cluster pertaining to this paper, XLSSC 005, is most likely a double cluster complex at a redshift around unity, associated with an extended X-ray source with probable substructure. [less ▲]

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See detailLimiting windstorm effects on tower by the « low drag » cable
Lilien, Jean-Louis ULg; Snegovski, Dmitri; Capelle, Thierry et al

(2004, August)

Hurricane winds affect the flow around electrical conductor in a way that it may reach the critical (Drag crisis) and postcritical states. It is thus important to introduce the cable aerodynamic drag as ... [more ▼]

Hurricane winds affect the flow around electrical conductor in a way that it may reach the critical (Drag crisis) and postcritical states. It is thus important to introduce the cable aerodynamic drag as Reynolds-dependent when calculating the response of the power transmission line under hurricane. To represent the respective wind loading on cable, the turbulent, spatially non-uniform wind model is used. In order to assess the behaviour and cyclic fatigue loads under hurricane conditions of different transmission line conductors, the time response analyses were done. Results of comparative study of the smooth cable AERO-Z and classical multistrand cable, including the percentage of load reduction offered to supporting structure, are presented. [less ▲]

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See detailAssessment of the Electric and Magnetic field levels in the vicinity of the HV overhead power lines in Belgium.
Hoeffelman, Jean; Decat, Gilbert; Lilien, Jean-Louis ULg et al

in Conférence Internationale des Grands Réseaux Electriques à Haute Tension - CIGRE (2004, August)

Maximum exposure levels in the vicinity of HV power lines in Belgium.

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See detailShort-circuit mechanical effects on outdoor HV substations with wide bundling.
Pitz, Volker; Köster, Hans-Joachim; Stein, Norbert et al

in Conférence Internationale des grands réseaux électriques à haute tension - CIGRE (2004, August)

This paper presents results of a research project investigating the mechanical effects of short-circuit currents in high-voltage substations with conductor bundles. The experimental part was performed on ... [more ▼]

This paper presents results of a research project investigating the mechanical effects of short-circuit currents in high-voltage substations with conductor bundles. The experimental part was performed on two set-ups, called "100 kV arrangement" and "400 kV arrangement". Those two set-ups differed in the height of the crossarm, the phase-to-phase distance and the conductor sag. Additional parameters which were varied in the course of the experiments included the level and duration of the short-circuit current, the type and number of the spacers used and the bundle spacing. Various forces in the flexible busbar and the supporting structure were recorded during the tests and the stiffness as well as the eigenfrequency of the portals used for supporting the conductors were determined. The test results were evaluated with respect to the maxima of the pinch force, the tensile force and the drop force. They are presented and compared with existing assumptions and calculation methods. The results of this project shall enable IEC standardization committees and CIGRE working groups to carry on with their intended studies and establish a comprehensive method of calculating the mechanical effects in substations with bundle conductors. [less ▲]

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See detailA heat piloted residential 5 kW fuel cell
Lilien, Jean-Louis ULg; Maréchal, François; Lerson, Sébastien et al

(2004, August)

based on residential house demand (electrical, heating, domestic hot water), the optimisation of the use of a SOFC fuel cell of about 5 kWe is detailed to reduce CO2 emission at their minimum.

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See detailSelf-recognition in everyday life
Brédart, Serge ULg; Young, A. W.

in Cognitive Neuropsychiatry (2004), 9(3), 183-197

INTRODUCTION: A sample of everyday difficulties was collected, encompassing errors and unusual experiences participants had encountered when recognising their own faces in everyday life, with the aim of ... [more ▼]

INTRODUCTION: A sample of everyday difficulties was collected, encompassing errors and unusual experiences participants had encountered when recognising their own faces in everyday life, with the aim of characterising similarities and differences between the reported difficulties and the major forms of self-recognition impairments described in the neuropsychological and neuropsychiatric literatures (prosopagnosia, mirrored-self misidentification, and Capgras delusion). METHOD: A total of 70 participants recalled experiences from memory. Incidents (n = 51) were recorded on questionnaire sheets that were filled out at home. Reports of three categories of incidents were analysed: misidentifications (the participant misidentified her/his own face as being that of another familiar person; n = 5), recognition failures (the participant judged that his/her own face was that of an unfamiliar person; n = 20) and perception of unusual aspects (the participant confidently recognised his/her own face but found that the seen face did not fit well the representation she/he had of his/her own face; n = 26). RESULTS AND DISCUSSION: In the reported incidents, experiences showing some similarities to those of patients with prosopagnosia, Capgras delusion or mirrored-self misidentification were noted. However, across the whole study, no incident involved a failure of reality testing; in contrast to pathological forms of error, in all of the reported incidents from our study the participant realised that a mistake had been made. The importance of decision processes in pathological forms of own-face misrecognition is discussed. [less ▲]

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See detailThe equilibrium finite element model and error estimation for plate bending
Nguyen-Xuan, Hung; Debongnie, Jean-François ULg

Conference (2004, August)

This paper presents a procedure for computing approximate solution of bending Kirchhoff plate with an equilibrium finite element model. The accuracy of the equilibrium approach is evaluated through the ... [more ▼]

This paper presents a procedure for computing approximate solution of bending Kirchhoff plate with an equilibrium finite element model. The accuracy of the equilibrium approach is evaluated through the concept of error estimator. Especially, a dual analysis by finite elements which leads to lower and upper bounds of the exact solution is presented in numerical examples. [less ▲]

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See detailDiversité intra-organisationnelle et sens au travail dans les centres d'appels externes
Naedenoen, Frédéric ULg; Zune, Marc

Conference (2004, August)

Après avoir décrit le secteur des centres d’appels sous les traits universels d’un post-taylorisme, la littérature souligne depuis peu l’hétérogénéité du secteur. Nous concentrons notre propos sur la ... [more ▼]

Après avoir décrit le secteur des centres d’appels sous les traits universels d’un post-taylorisme, la littérature souligne depuis peu l’hétérogénéité du secteur. Nous concentrons notre propos sur la diversité organisationnelle présente au sein même d’une entreprise et mettons en évidence l’existence de deux logiques organisationnelles en tension, que nous qualifions de centrifuge et de centripète. A partir du concept giddensien de "région", nous envisageons ensuite les conséquences de cette situation sur le sens que les téléopérateurs donnent à leur travail. [less ▲]

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See detailA distributed algorithm for weighted max-min fairness in MPLS networks
Skivée, Fabian ULg; Leduc, Guy ULg

in Lecture Notes in Computer Science (2004, August), 3124

We propose a novel distributed algorithm to achieve a weighted max-min sharing of the network capacity. We present the Weight Proportional Max-Min policy (WPMM) that supports a minimal rate requirement ... [more ▼]

We propose a novel distributed algorithm to achieve a weighted max-min sharing of the network capacity. We present the Weight Proportional Max-Min policy (WPMM) that supports a minimal rate requirement and an optional maximal rate constraint and allocates network bandwidth among all aggregates based on a weight associated with each one. Our algorithm achieves this policy for IP/MPLS networks using the RSVP-TE signalling protocol. It uses per-LSP accounting in each node to keep track of the state information of each LSP. It uses a novel explicit bottleneck link strategy and a different control architecture in which we update the control packet in the forward path. Simulations show that these two elements improve substantially the convergence time compared to algorithms designed for ATM networks. [less ▲]

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See detailFirst Ground-Based Validation of SCIAMACHY V5.01 Ozone Column
Lambert, Jean-Christopher; Allaart, M; Andersen, S.B. et al

in Proceedings of the Second Workshop on the Atmospheric Chemistry Validation of ENVISAT (ACVE-2), ESA-ESRIN, Frascati, Italy, 3-7 May 2004 (ESA SP-562, August 2004) ESC01JL1 (2004, August)

In early 2004, the near real-time data processor of ENVISAT SCIAMACHY (SCI_NL) was upgraded to version 5.01. Based on the correlative measurements acquired and collected during the commissioning phase of ... [more ▼]

In early 2004, the near real-time data processor of ENVISAT SCIAMACHY (SCI_NL) was upgraded to version 5.01. Based on the correlative measurements acquired and collected during the commissioning phase of the satellite in 2002, a preliminary validation was organised to verify the improvement and assess the geophysical consistency of the new SCIAMACHY ozone vertical column data product. The present overview summarises the results obtained by a list of validation teams and involving ground-based data acquired from pole to pole by complementary ground-based sensors. The studies conclude to an improvement compared to previous versions 3.5x. They also confirm the presence of expected errors (e.g. dependence on solar elevation and on ozone column) inherited from the GOME Data Processor GDP 2.4, on which the SCIAMACHY processor SCI_NL is based. [less ▲]

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See detailGeophysical Validation of SCIAMACHY NO2 Vertical Columns: Overview of Early 2004 Results
Lambert, Jean-Christopher; Blumenstock, Thomas; Boersma, F. et al

in Proceedings of the Second Workshop on the Atmospheric Chemistry Validation of ENVISAT (ACVE-2), ESA-ESRIN, Frascati, Italy, 3-7 May 2004 (ESA SP-562, August 2004) ESC01JL1 (2004, August)

Following the recommendations drawn after the Commissioning Phase of the ENVISAT satellite in 2002, SCIAMACHY near real time data processors were upgraded to version 5.01 in early 2004. Before public ... [more ▼]

Following the recommendations drawn after the Commissioning Phase of the ENVISAT satellite in 2002, SCIAMACHY near real time data processors were upgraded to version 5.01 in early 2004. Before public release of the new SCIAMACHY nitrogen dioxide (NO2) vertical column data product, several validation teams investigated its improvement and assessed its geophysical consistency by means of correlative studies involving NDSC-affiliated ground-based networks of DOAS UV-visible and FTIR spectrometers and the ERS-2 GOME satellite. In parallel, preliminary SCIAMACHY NO2 column data products generated by research processors under development at scientific institutes were also tested, using the same correlative data and validation procedures. Digesting the results obtained by a list of validation teams and SCIAMACHY data processing teams, this overview paper draws a preliminary quality assessment of the SCIAMACHY NO2 column data sets available in spring 2004. [less ▲]

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See detailTransformations graphiques
Badir, Sémir ULg

in E/C (2004)

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See detailQuando la scrittura diventa testura dell'immagine
Dondero, Maria Giulia ULg

in Espressione/Contenuto : Rivista dell’Associazione Italiana di Studi Semiotici (2004)

Cet article porte sur un corpus de photographies écrites et peintes qui pose le problème des relations (contractuelles et contrastives) entre texte photographique, écriture manuelle et gestualité ... [more ▼]

Cet article porte sur un corpus de photographies écrites et peintes qui pose le problème des relations (contractuelles et contrastives) entre texte photographique, écriture manuelle et gestualité picturale. L’écriture dans l’image est étudiée comme : 1) stratégie d’authentification de l’objet-photo (autographie de l’objet photographique unique), 2) comme notation, 3) comme gestualité, 4) comme effet-texture de l’image. L’écriture entendue comme stratégie d’authentification du texte photographique permet de réfléchir sur la problématique de l’original, de la reproductibilité et du statut hybride de la photographie écrite, à mi-chemin entre autographie et allographie (« texte autographique à objet multiple »). [less ▲]

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See detailProcess for depositing strong adherend polymer coating onto an electrically conductive surface
Bertrand, Olivier; Jérôme, Robert ULg; Gautier, Sandrine et al

Patent (2004)

Process for depositing by electrografting a strong adherent polymer coating onto an electrically conductive surface comprising the step of electrochemical grafting of an active monomer for forming a ... [more ▼]

Process for depositing by electrografting a strong adherent polymer coating onto an electrically conductive surface comprising the step of electrochemical grafting of an active monomer for forming a primer coating P onto the surface and having as general formula: X0 (meth)acrylate wherein X is either part of a preformed polymer or is an intermediate agent for polyaddition reaction or is an anchoring group for attachment of a molecule having at least one complementary reactive group. Such process allows formation of new primer by one-step electro-grafting of a macromonomer. Such process also allows further modification of an initial electrografted polymer to increase the coating thickness by the grafting-from technique. Such process also allows to graft onto the primer coating compounds like functional polymer, peptide, protein, oligonucleotide, dyes, drugs, anti-bacterian compounds. [less ▲]

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See detailcaveolin-1 expression is critical for VEGF-induced inschemic hindlimb collateralization and NO-mediated angiogenisis.
Martinive, Philippe ULg; Sonveaux, P; DeWever, J et al

in Circulation Research (2004), (95 (2)), 154-61

Nitric oxide (NO) is a powerful angiogenic mediator acting downstream of vascular endothelial growth factor (VEGF). Both the endothelial NO synthase (eNOS) and the VEGFR-2 receptor colocalize in caveolae ... [more ▼]

Nitric oxide (NO) is a powerful angiogenic mediator acting downstream of vascular endothelial growth factor (VEGF). Both the endothelial NO synthase (eNOS) and the VEGFR-2 receptor colocalize in caveolae. Because the structural protein of these signaling platforms, caveolin, also represses eNOS activity, changes in its abundance are likely to influence the angiogenic process in various ways. In this study, we used mice deficient for the caveolin-1 gene (Cav-/-) to examine the impact of caveolae suppression in a model of adaptive angiogenesis obtained after femoral artery resection. Evaluation of the ischemic tissue perfusion and histochemical analyses revealed that contrary to Cav+/+ mice, Cav-/- mice failed to recover a functional vasculature and actually lost part of the ligated limbs, thereby recapitulating the effects of the NOS inhibitor L-NAME administered to operated Cav+/+ mice. We also isolated endothelial cells (ECs) from Cav-/- aorta and showed that on VEGF stimulation, NO production and endothelial tube formation were dramatically abrogated when compared with Cav+/+ ECs. The Ser1177 eNOS phosphorylation and Thr495 dephosphorylation but also the ERK phosphorylation were similarly altered in VEGF-treated Cav-/- ECs. Interestingly, caveolin transfection in Cav-/- ECs redirected the VEGFR-2 in caveolar membranes and restored the VEGF-induced ERK and eNOS activation. However, when high levels of recombinant caveolin were reached, VEGF exposure failed to activate ERK and eNOS. These results emphasize the critical role of caveolae in ensuring the coupling between VEGFR-2 stimulation and downstream mediators of angiogenesis. This study also provides new insights to understand the paradoxical roles of caveolin (eg, repressing basal enzyme activity but facilitating activation on agonist stimulation) in cardiovascular pathophysiology. [less ▲]

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See detailContribution to the design of sway composite frames
Maquoi, René ULg; Jaspart, Jean-Pierre ULg; Demonceau, Jean-François ULg

in Leon, Roberto; Lange, Jörg (Eds.) Composite Construction in Steel and Concrete V (2004, July 18)

This paper presents numerical and analytical studies carried out at Liège University, as part of a European research project, with the objective to investigate the in-plane behaviour of composite sway ... [more ▼]

This paper presents numerical and analytical studies carried out at Liège University, as part of a European research project, with the objective to investigate the in-plane behaviour of composite sway frames under static loading. [less ▲]

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See detailIn-situ polymerization of monoethylenically unsaturated monomers with oligomeric or polymeric secondary amines
Detrembleur, Christophe ULg; Rüdiger, Claus; Meyer, Rolf-Volker

Patent (2004)

PROBLEM TO BE SOLVED: To provide a process for preparing a (co)oligomer or a (co)polymer. ; SOLUTION: The process for preparing a (co)oligomer or (co)polymer comprises forming a mixture containing a ... [more ▼]

PROBLEM TO BE SOLVED: To provide a process for preparing a (co)oligomer or a (co)polymer. ; SOLUTION: The process for preparing a (co)oligomer or (co)polymer comprises forming a mixture containing a monoethylencally unsaturated monomer of formula (M): HR<SP>1</SP>C=CR<SP>2</SP>R<SP>3</SP>, an oxidizing agent, at least one polymer or oligomer of formula (I), and an optional radical initiator and heating the mixture at 0-220[deg.]C. [less ▲]

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