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See detailThe management of rectal cancer in Belgium: a survey of our practice
Vanderick, JEAN ULg; BEAUDUIN; DENEUFBOURG et al

in Acta gastro-enterologica belgica (2004), 67(1), 9-13

In 1995, a Peer Review Commission Radiotherapy was installed at the initiative of the Belgian Ministry of Health as part of a larger pilot project on quality assurance. This commission was composed of 14 ... [more ▼]

In 1995, a Peer Review Commission Radiotherapy was installed at the initiative of the Belgian Ministry of Health as part of a larger pilot project on quality assurance. This commission was composed of 14 members, 8 radiation oncologists (appointed by the Belgian Association of Radiation Oncology) and 6 physicists (appointed by the Belgian Association of Hospital Physicists). Peer review is only one of the activities within the Quality control of the medical performance aiming to improve quality in diagnostic and therapeutic procedures. Other activities in Quality assurance are development of standards and guidelines, continuous education and measurements of the treatment process. In 1998, the Peer review Commission Radiotherapy has proposed to make a survey of rectal cancer management including diagnostic procedures and therapeutic approaches. More than 1300 questionnaires were sent to the chairman of the 25 Belgian radiotherapy departments, asking them to have it filled in by the radiation oncologist in charge of rectal cancer treatment in their department and to all the known surgeons from a list provided by the Ministry of Health. The paper reports and discuss the results of this survey. [less ▲]

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See detailState of the art and challenges of post-harvest diseases management in apples
Jijakli, Haissam ULg; Lepoivre, Philippe ULg

in Mukerij, K. G. (Ed.) Disease Management of fruit and vegetables (2004)

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See detailApproche quantitative de la consommation alimentaire en Région wallonne
Duquesne, Brigitte ULg; Cordier, L.

in Rencontre Agriculture – Alimentation – Santé (2004)

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See detailOmega-regular model checking
Boigelot, Bernard ULg; Legay, A.; Wolper, Pierre ULg

in Lecture Notes in Computer Science (2004), 2988

"Regular model checking" is the name of a family of techniques for analyzing infinite-state systems in which states are represented by words or trees, sets of states by finite automata on these objects ... [more ▼]

"Regular model checking" is the name of a family of techniques for analyzing infinite-state systems in which states are represented by words or trees, sets of states by finite automata on these objects, and transitions by finite automata operating on pairs of state encodings, i.e. finite-state transducers. In this context, the central problem is then to compute the iterative closure of a finite-state transducer. This paper addresses the use of regular model-checking like techniques for systems whose states are represented by infinite (omega) words. Its main motivation is to show the feasibility and usefulness of this approach through a combination of the necessary theoretical developments, implementation, and experimentation. The iteration technique that is used is adapted from recent work of the authors on the iteration of finite-word transducers. It proceeds by comparing successive elements of a sequence of approximations of the iteration, detecting an "increment" that is added to move from one approximation to the next, and extrapolating the sequence by allowing arbitrary repetitions of this increment. By restricting oneself to weak deterministic Buchi automata, and using a number of implementation optimizations, examples of significant size can be handled. The proposed transducer iteration technique can just as well be exploited to compute the closure of a given set of states by the transducer iteration, which has proven to be a very effective way of using the technique. Examples such as a leaking gas burner in which time is modeled by real variables have been handled completely within the automata-theoretic setting. [less ▲]

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See detailQue pense l'équipage ?
Jacquemain, Marc ULg

in Delruelle, Edouard; Brausch, Géraldine (Eds.) Le droit sans la justice (2004)

The text is a question adressed to positivist theory of law : to what extent can a positivist theory of law be understandable for profesionals, giving that the practice of law seems to have as a ... [more ▼]

The text is a question adressed to positivist theory of law : to what extent can a positivist theory of law be understandable for profesionals, giving that the practice of law seems to have as a presuposition some kind of a "realist" theory of the law ? [less ▲]

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See detailUtilisation des plantes à tubercules ou à racines tubéreuses en alimentation animale.
Bindelle, Jérôme ULg; Buldgen, André

Article for general public (2004)

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See detailGain baro-réflexe calculé lors d’un test d’orthostatisme (« squatting ») : reproductibilité et effet de l’âge dans une population normale
PHILIPS, Jean-Christophe ULg; MARCHAND, Monique ULg; Estrella, F. et al

in Archives des Maladies du Coeur et des Vaisseaux (2004), 97(suppl), 5392

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See detailInfluence of blood glucose control on the progression of cardiac autonomic neuropathy in Type 1 diabetes.
PHILIPS, Jean-Christophe ULg; MARCHAND, Monique ULg; Geronooz, I. et al

in Diabetologia (2004), 47(suppl 1), 368-3691029

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See detailQuestionner le questionnement. Exemple d’une démarche réflexive appliquée à l’intervention en sport)
Lenzen, Benoît; Bonfond, Jeanne-Marie ULg; Cloes, Marc ULg

in Léziart, Y.; Loquet, M. (Eds.) Cultures sportives et artistiques. Formalisation des savoirs professionnels. Pratiques, formations, recherches. Actes du colloque international ARIS (2004)

Les scientifiques qui ancrent leurs recherches dans le vaste champ des sciences cognitives sont de plus en plus nombreux à s’interroger sur les méthodes qu’ils emploient. De la « connaissance de la ... [more ▼]

Les scientifiques qui ancrent leurs recherches dans le vaste champ des sciences cognitives sont de plus en plus nombreux à s’interroger sur les méthodes qu’ils emploient. De la « connaissance de la connaissance » (Morin, 1986) au « point de vue radicalement en première personne » (Vermersch, 2000a) en passant par la « situation d’étude privilégiée » (Grison, 1998), cette préoccupation épistémologique commence à intégrer progressivement le domaine de l’intervention en sport. [less ▲]

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See detailImpact of surfactants on the biotransformation of methyl ricinoleate into γ-decalactone by Yarrowia lipolytica
Aguedo, Mario ULg; Waché, Y.; Coste, F. et al

in Journal of Molecular Catalysis B : Enzymatic (2004), 29(1-6), 31-36

Surfactants play a key role in the biotechnological degradation of hydrophobic substrates, however this role is often misunderstood. During the biotransformation of methyl ricinoleate into the aroma ... [more ▼]

Surfactants play a key role in the biotechnological degradation of hydrophobic substrates, however this role is often misunderstood. During the biotransformation of methyl ricinoleate into the aroma compound γ-decalactone by the yeast Yarrowia lipolytica, a direct contact occurs between the surface of the cells and the small droplets of substrate. The impact of a series of surfactants on this process was investigated. Both ionic surfactants tested were toxic towards the yeast. This effect may be linked to a decrease in the cell membrane integrity. The interfacial area of the emulsion varied according to the non-ionic surfactant used, and this factor was correlated with the productivity of the biotransformation. By evaluating the effect of surfactants on the capacity of the cells to adhere to decane (MATH test), it was shown that the adhesion of methyl ricinoleate on yeast surface is not a rate-limiting point for the process. © 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailDelivery of granulocyte-macrophage colony-stimulating factor in bioadhesive hydrogel stimulates migration of dendritic cells in models human papillomavirus-associated (pre)neoplastic epithelial lesions
Hubert, Pascale ULg; Evrard, Brigitte ULg; Maillard, Catherine ULg et al

in Antimicrobial Agents and Chemotherapy (2004), 48(11), 4342-4348

Because of the central role of dendritic cells and/or Langerhans cells(DC/LC) in the induction of cellular immune responses, pharmacological agents that modulate the recruitment of these cells might have ... [more ▼]

Because of the central role of dendritic cells and/or Langerhans cells(DC/LC) in the induction of cellular immune responses, pharmacological agents that modulate the recruitment of these cells might have a clinical interest. The present study was designed to evaluate the capacity of several pharmaceutical formulations to topically deliver granulocyte-macrophage colony-stimulating factor (GM-CSF) on human papillomavirus (HPV)-associated genital (pre)neoplastic lesions. The formulations were evaluated for their bioactivity and for their potential to recruit DC in organotypic cultures of HPV-transformed keratinocytes. We found that a bioadhesive polycarbophil gel (Noveon) at pH 5.5 is able to maintain the bioactivity of GM-CSF at 4 or 37°C for at least 7 days, whereas a decreased activity of GM-CSF was observed when the molecule is included in other polymer gels. GM-CSF incorporated in the polycarbophil gel was also a potent factor in enhancing the colonization of DC into organotypic cultures of HPV-transformed keratinocytes since the infiltration of DC in the in vitro-formed (pre)neoplastic epithelium was very low under basal conditions and dramatically increased in the presence of GM-CSF gel. We next demonstrated that GM-CSF incorporated in polycarbophil gel induces the recruitment of human DC in a human (pre)neoplastic epithelium grafted into NOD/SCID mice. The efficacy of GM-CSF in this formulation was equivalent to that observed with liquid GM-CSF. These results suggest that GM-CSF incorporated in polycarbophil gel could play an important role in the recruitment of DC/LC in mucosal surfaces and be useful as a new immunotherapeutic approach for genital HPV-associated (pre)neoplastic lesions. [less ▲]

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See detailGenetic engineering of the β-oxidation pathway in the yeast Yarrowia lipolytica to increase the production of aroma compounds
Groguenin, A.; Waché, Y.; Garcia, E. E. et al

in Journal of Molecular Catalysis B : Enzymatic (2004), 28(2-3), 75-79

The yeast Yarrowia lipolytica possesses five acyl-CoA oxidases (Aox1p to 5), the enzyme catalysing the first reaction of β-oxidation. The understanding of the specific role of each acyl-CoA oxidase is ... [more ▼]

The yeast Yarrowia lipolytica possesses five acyl-CoA oxidases (Aox1p to 5), the enzyme catalysing the first reaction of β-oxidation. The understanding of the specific role of each acyl-CoA oxidase is important to construct a yeast strain growing at a good rate and able to produce without degrading the aroma compound γ-decalactone. In this study we observed that Aox4p exhibits a slight activity on a broad spectrum of substrates and that it is involved in lactone degradation. We constructed a strain lacking this activity. Its growth was only slightly altered and it produced 10 times more lactone than the wild type in 48h. © 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailThe Same, Yet Different: Caryl Phillips's Screen Adaptation of V.S. Naipaul's The Mystic Masseur
Ledent, Bénédicte ULg

in Misrahi-Barak, Judith (Ed.) V.S. Naipaul: A World in Tension / Une oeuvre sous tension (2004)

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See detailBen Okri's The Landscapes Within and Dangerous Love: Vision and Revision
Tunca, Daria ULg

in BELL. Belgian Journal of English Language and Literatures (2004), 2

In 1981, Nigerian author Ben Okri published The Landscapes Within, a novel about a young painter’s life and creative aspirations. This work, in Okri’s own words, “continued to haunt [him] and trouble [him ... [more ▼]

In 1981, Nigerian author Ben Okri published The Landscapes Within, a novel about a young painter’s life and creative aspirations. This work, in Okri’s own words, “continued to haunt [him] and trouble [him] through the years, because in its spirit and essence [he] sensed that it was incomplete.” Therefore, he published a revised version of this early book, under the title Dangerous Love, in 1996. By way of introduction, this article will briefly outline the meanings of these different titles. Then, starting from a close reading of the narratives, I shall argue that the major factors of differentiation between the novels are not to be found on the level of plot, but mainly lie in the importance given to certain statements, metaphors, and the degree of accomplishment of the painter’s work. Importantly, these modifications are paralleled by significant stylistic changes. If language plays a determining role on the formal level, it will also be analysed as an important thematic concern of both the author and his protagonist. Indeed, the second version of the novel questions not only the appropriateness of English in post-colonial African settings, but also the relevance of language in general as a medium of artistic representation. [less ▲]

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See detail"Of, and not of, this Place": Attachment and Detachment in Caryl Phillips' A Distant Shore
Ledent, Bénédicte ULg

in Kunapipi : Journal of Postcolonial Writing (2004), 26(1), 152-160

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See detailThe use of enzymes and microorganisms for the production of aroma compounds from lipids
Aguedo, Mario ULg; Ly, M. H.; Belo, I. et al

in Food Technology and Biotechnology (2004), 42(4), 327-336

Lipids are an important source of aroma compounds. In foods, lipids are degraded or modified by enzymatic activities that are originally present in the raw materials or that develop later due to the ... [more ▼]

Lipids are an important source of aroma compounds. In foods, lipids are degraded or modified by enzymatic activities that are originally present in the raw materials or that develop later due to the growth of microorganisms. Mimicking these natural pathways, some processes have been developed to produce aroma compounds in bioreactors. In this review we describe the production of aroma compounds from different families: lactones, green notes and ionones. We focus on points that are specific to these reactions in heterogeneous media: physicochemical forces involved in the interactions between the substrate, product and biocatalyst, transfers between the phases and, as the degradation of lipids often requires an oxidation step, on the problems of oxygenation of the reactors. [less ▲]

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See detailVers une réforme du Fonds des communes en Région wallonne
Husson, Jean-François ULg

in Courrier Hebdomadaire du CRISP (2004), (1849-1850), 5-74

This paper analyses the whole debate on the reform of the general grant mechanism ("Fonds des Communes") aimed at walloon municipalities. Developments in other Belgian Regions are also considered.

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See detailEffect of ADAMTS-2, a metalloproteinase containing a disintegrin domain and thrombospondin type I repeats, during angiogenesis in vitro and in vivo
Dubail, Johanne ULg; Kesteloot, Frédéric ULg; Motte, Patrick ULg et al

in Angiogenesis (2004), 7(2), 172

Formation of new blood vessels (angiogenesis) is a key step during the development of various pathologies, including cancer. Enzymes of the ADAMTS family are closely related to MMPs and ADAMs. They ... [more ▼]

Formation of new blood vessels (angiogenesis) is a key step during the development of various pathologies, including cancer. Enzymes of the ADAMTS family are closely related to MMPs and ADAMs. They further contain specific domains, such as the ‘‘Thrombospondin type I’’ (TSP1) repeats, that are able to strongly repress angiogenesis, as described for thrombospondin-1 and -2, and for ADAMTS-1 and -8. The primary function of ADAMTS-2 is to process collagen type I, II and III precursors into mature molecules by excising the aminopropeptide. We further hypothesized that it could modulate angiogenesis through its TSP1 repeats. This hypothesis was investigated using different in vitro experimental models of angiogenesis. Recombinant ADAMTS-2 induced morphological changes in human umbilical vein endothelial cells (HUVEC) and human microvessel endothelial cells (HMEC), and significantly reduced their proliferation, attachment and spreading. Similar effects were observed when using inactive ADAMTS-2 mutated at the Zn2+-binding catalytic site. ADAMTS-2 did not alter the initial steps of formation of capillary-like structures by HUVEC in vitro. However, these structures appeared much less stable and were more rapidly disrupted in presence of ADAMTS-2 than in control conditions. ADAMTS-2 was also tested in an ex vivo angiogenesis model using aortic rings from rats and mice, wild type or KO for ADAMTS-2. Outgrowth of capillaries was slightly increased from aortas of ADAMTS-2 KO mice (TS2-/-) as compared to aortas from control animals (TS2+/+), while addition of full size recombinant ADAMTS-2 reduced the formation of capillary structures from rat aortas, suggesting its anti-angiogenic activity. Choroidal neovascularization induced in TS2+/+ or TS2-/- mice by LASER burns was used as in vivo model to confirm the in vitro and ex vivo results. Several genes involved in the healing and angiogenesis processes (fibrillar collagens, VEGF, TGF-beta and CTGF) were not differently regulated in TS2+/+ and TS2-/- mice at 5 days. [less ▲]

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See detailInvasion and MMP expression profile in desmoid tumours.
Denys, H.; De Wever, O.; Nusgens, Betty ULg et al

in British Journal of Cancer (2004), 90(7), 1443-9

Desmoid tumours are locally invasive soft tissue tumours in which beta-catenin mediated TCF-dependent transcription is activated. The role of soluble factors secreted by the myofibroblastic desmoid tumour ... [more ▼]

Desmoid tumours are locally invasive soft tissue tumours in which beta-catenin mediated TCF-dependent transcription is activated. The role of soluble factors secreted by the myofibroblastic desmoid tumour, which could stimulate tumour invasiveness, was investigated. Using collagen gel invasion assays, the presence of factors stimulating invasion in desmoid conditioned media (CM) could be established. Since matrix metalloproteinases (MMPs) have been implicated in the process of tumoral invasion, the expression levels of the MMP family members were evaluated. Quantitative reverse transcription-PCR was used to determine the expression levels of MMP1, MMP2, MMP3, MMP7, MMP11, MMP12, MMP13, MMP14 and the inhibitors TIMP1, TIMP2 and TIMP3. Besides overexpression of MMP7, a known TCF-dependent target gene, a striking upregulation of the expression levels of MMP1, MMP3, MMP11, MMP12 and MMP13 in desmoid tumours, compared to unaffected fibroblasts from the same patients, was found. Treating the CM of desmoids with a synthetic and a physiologic MMP inhibitor reduced the invasion-stimulating capacity of the desmoid CM by approximately 50%. These results suggest the involvement of soluble factors, released by the desmoid cells, in stimulating invasion and implicate the MMPs as facilitators of invasion. [less ▲]

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