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See detailGeldanamycin inhibits tyrosine phosphorylation-dependent NF-kB activation
Crèvecoeur, Julie ULg; Piette, Jacques ULg; Gloire, Geoffrey ULg

in Biochemical Pharmacology (2008), 75(11), 2183-2191

Hsp90 is a protein chaperone regulating the stability and activity of many signalling molecules. The requirement of Hsp90 activity in the NF-κB pathway has been recently reported by several authors using ... [more ▼]

Hsp90 is a protein chaperone regulating the stability and activity of many signalling molecules. The requirement of Hsp90 activity in the NF-κB pathway has been recently reported by several authors using the Hsp90 ATPase inhibitor Geldanamycin (GA), an anti-tumour drug. Hsp90 inhibition blocks the synthesis and activation of the IKK complex, the major kinases complex responsible for IκBα phosphorylation on serine 32 and 36, a key step for its degradation and the nuclear translocation of NF-κB. However, the effect of GA on other IκBα kinases, including tyrosine kinases, is unknown. In the present study, we investigated the effect of GA on NF-κB activation induced by sodium pervanadate (PV), a tyrosine phosphatase inhibitor triggering c-Src-mediated tyrosine phosphorylation of IκBα. We reporte for the first time that GA inhibits PV-induced IκBα tyrosine phosphorylation and degradation. Using an in vitro kinase assay, we demonstrated that GA inhibits the activity of c-Src as an IκBα tyrosine kinase, but not its cellular expression. As a result, GA blocked PV-induced NF-κB DNA binding activity on an exogenous κB element and on the endogenous iκbα promoter, thereby inhibiting IκBα transcription. Finally, we demonstrated that, despite NF-κB inhibition, pre-treatment with GA does not potentiate PV-induced apoptosis. We conclude that c-Src requires Hsp90 for its tyrosine kinase activity, and its inhibition by GA blocks c-Src-dependent signalling pathways, such as NF-κB activation induced by sodium pervanadate. The effect of GA on PV-induced apoptosis is discussed in the light of recent publications in the literature. [less ▲]

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See detailPas si zen: des plantes de maïs stressées sont placées sous haute surveillance
Périlleux, Claire ULg

Article for general public (2008)

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See detailAstrobiology : origin, evolution and distribution of life in the universe
Javaux, Emmanuelle ULg

in CAPAS Bulletin de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique. Sciences (2008)

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See detailImposing monotonicity in parametric distance functions
Santin, D.; Perelman, Sergio ULg

in Applied Economics (2008)

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See detailCAP Reforms and Total Factor Productivity Growth: An Analysis of Belgian Farm-level Data
Coelli, Tim; Van Lierde, Dirk; Perelman, Sergio ULg

Report (2008)

Have the 1992 and 2000 CAP reforms had any discernable effect upon agricultural productivity? In this study we derive detailed information on the total factor productivity (TFP) growth of arable farms in ... [more ▼]

Have the 1992 and 2000 CAP reforms had any discernable effect upon agricultural productivity? In this study we derive detailed information on the total factor productivity (TFP) growth of arable farms in Belgium over a 16-year period from 1987 to 2002. Calculations are based on a carefully constructed high-quality detailed farm-level data set containing 1728 observations, involving over 100 farms in most years. Three output variables (cereals, other crops, other outputs) and four input variables (land, labour, capital and other inputs) are constructed, using multilateral Fisher index numbers where crop aggregation is required. The TFP measures are calculated using a Malmquist TFP index relative to a series of data envelopment analysis (DEA) frontiers. Annual average TFP change of 1.0% per year is estimated for this industry. This rate does not compare well with rates of over 2% that are commonly reported in studies involving other developed countries. The pattern of TFP growth over the period indicates that the two CAP reforms (in 1992 and 2000) have had no discernable effect upon TFP trends. An inspection of shadow shares (derived from the DEA frontiers) indicates that substantial distortions remain in this industry, especially with regards to the excess use of labour and constrained use of land, relative to other inputs. Finally, tabulation of results by region and farm size shows fairly uniform TFP change across regions, but poor performance in small farms, where TFP actually levels actually fell over this period. [less ▲]

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See detailA damage/repair model for alveolar bone remodeling
Mengoni, Marlène ULg; Ponthot, Jean-Philippe ULg

in Middleton; Evans; Holt (Eds.) et al 8th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering : CMBBE2008, Porto, Porugal (2008)

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See detailLand Values
Halleux, Jean-Marie ULg; Huls, J.; Merenne-Schoumaker, Bernadette ULg

Report (2008)

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See detailCarte géologique de Wallonie échelle 1/25.000, Maffe - Grandhan 54/3-4
Barchy, Laurent ULg; Marion, Jean-Marc ULg

Cartographic material (2008)

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous edition of Lohest and Mourlon, published in 1900 ... [more ▼]

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous edition of Lohest and Mourlon, published in 1900 at the scale of 1/40.000 by the "Commission Géologique de Belgique". [less ▲]

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See detailValorisation of Microsimulation Model for Social Security Mimosis
Decoster, André; Maréchal, Claire; Paszukiewicz, Alexis ULg et al

Report (2008)

This report is part of the output of the project AG/01/116. The main objectives of project AG/01/116 were to further refine and validate the microsimulation model for social security, MIMOSIS, both by ... [more ▼]

This report is part of the output of the project AG/01/116. The main objectives of project AG/01/116 were to further refine and validate the microsimulation model for social security, MIMOSIS, both by extending the data coverage and refining the modules as through a comparative study of how MIMOSIS is positioned in an international perspective and also by use of MIMOSIS for evaluation of (hypothetical) policy reforms. [less ▲]

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See detailAnnotation sous TPICE, T-210/02, 23 décembre 2006, affaire des granulats
Petit, Nicolas ULg

in Aménagement - Environnement (2008), (2), 119

Les éxonérations de l'écotaxe sur l'extraction des granulats instaurée en 2001 constituaient-elles des aides d'état incompatibles avec le Traité CE?

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See detailThe impact of lateral carbon fluxes on the European carbon balance
Ciais, P.; Borges, Alberto ULg; Abril, Gwenaël et al

in Biogeosciences (2008), 5

To date, little is known about the impact of processes which cause lateral carbon fluxes over continents, and from continents to oceans on the CO2 – and carbon budgets at local, regional and continental ... [more ▼]

To date, little is known about the impact of processes which cause lateral carbon fluxes over continents, and from continents to oceans on the CO2 – and carbon budgets at local, regional and continental scales. Lateral carbon fluxes contribute to regional carbon budgets as follows: Ecosystem CO2 sink=Ecosystem carbon accumulation+Lateral carbon fluxes. We estimated the contribution of wood and food product trade, of emission and oxidation of reduced carbon species, and of river erosion and transport as lateral carbon fluxes to the carbon balance of Europe (EU-25). The analysis is completed by new estimates of the carbon fluxes of coastal seas. We estimated that lateral transport (all processes combined) is a flux of 165 Tg C yr−1 at the scale of EU-25. The magnitude of lateral transport is thus comparable to current estimates of carbon accumulation in European forests. The main process contributing to the total lateral flux out of Europe is the flux of reduced carbon compounds, corresponding to the sum of non-CO2 gaseous species (CH4, CO, hydrocarbons, . . . ) emitted by ecosystems and exported out of the European boundary layer by the large scale atmospheric circulation. [less ▲]

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See detailPerceptions and Preferences of Office Occupiers
Guilliams; Halleux, Jean-Marie ULg; Huls, J. et al

Report (2008)

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See detailPreliminary interviews with occupiers
Mairy, N.; Halleux, Jean-Marie ULg; Merenne-Schoumaker, Bernadette ULg

Report (2008)

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See detailStrain reduction in selectively grown CdTe by MBE on nanopatterned silicon on insulator (SOI) substrates
Bommena, R.; Seldrum, T.; Samain, Louise ULg et al

in Journal of Electronic Materials (2008), 37(9), 1255-1260

Silicon-based substrates for the epitaxy of HgCdTe are an attractive low-cost choice for monolithic integration of infrared detectors with mature Si technology and high yield. However, progress in ... [more ▼]

Silicon-based substrates for the epitaxy of HgCdTe are an attractive low-cost choice for monolithic integration of infrared detectors with mature Si technology and high yield. However, progress in heteroepitaxy of CdTe/Si (for subsequent growth of HgCdTe) is limited by the high lattice and thermal mismatch, which creates strain at the heterointerface that results in a high density of dislocations. Previously we have reported on theoretical modeling of strain partitioning between CdTe and Si on nanopatterned silicon on insulator (SOI) substrates. In this paper, we present an experimental study of CdTe epitaxy on nanopatterned (SOI). SOI (100) substrates were patterned with interferometric lithography and reactive ion etching to form a two-dimensional array of silicon pillars with similar to 250 nm diameter and 1 mu m pitch. MBE was used to grow CdTe selectively on the silicon nanopillars. Selective growth of CdTe was confirmed by scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). Coalescence of CdTe on the silicon nanoislands has been observed from the SEM characterization. Selective growth was achieved with a two-step growth process involving desorption of the nucleation layer followed by regrowth of CdTe at a rate of 0.2 angstrom s(-1). Strain measurements by Raman spectroscopy show a comparable Raman shift (2.7 +/- 2 cm(-1) from the bulk value of 170 cm(-1)) in CdTe grown on nanopatterned SOI and planar silicon (Raman shift of 4.4 +/- 2 cm(-1)), indicating similar strain on the nanopatterned substrates. [less ▲]

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See detailIntegrated assessment of flood protection measures in the context of climate change: hydraulic modelling and economic approach
Dewals, Benjamin ULg; Giron, Eve; Ernst, Julien ULg et al

in Aravossis, K.; Brebbia, C. A.; Gomez, Nieves (Eds.) Environmental Economics (2008)

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See detailEquality and diversity in jobs and services: City policies for migrants in Europe
Gsir, Sonia ULg; Martiniello, Marco ULg; Perrin, Nathalie et al

Book published by Eurofound and the Council of Europe (2008)

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See detailAutonomie fiscale, péréquation et contrainte budgétaire des communes: de la théorie à la pratique
Jurion, Bernard ULg

in Reflets et Perspectives de la Vie Economique (2008), XLVII(4), 5-14

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See detailEpidemiology of injuries in high-level youth sport in Luxembourg [Abstract]
Frisch, Anne ULg; Theisen, Daniel; Urhausen, Axel et al

in Knee Surgery, Sports Traumatology, Arthroscopy (2008), 16

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See detailIntroduction
Jamin, Jérôme ULg

in Pensée et les Hommes (La) (2008), 68

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