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See detailLe coenzyme Q10: biochimie, physiopathologie de sa carence et interet potentiel d'une augmentation de ses apports.
Malchair, P.; Van Overmeire, Lionel ULg; Boland, André ULg et al

in Revue Médicale de Liège (2005), 60(1), 45-51

After a brief reminding of the synthesis and function of coenzyme Q10, this article tries to summarise the current state of knowledge about the consequences of its deficiency and about the potential ... [more ▼]

After a brief reminding of the synthesis and function of coenzyme Q10, this article tries to summarise the current state of knowledge about the consequences of its deficiency and about the potential benefits of an increased intake of this coenzyme. We then describe the arguments in favour of such an increase in cardiac diseases and in Parkinson's disease. [less ▲]

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See detailRiver contract in Wallonia (Belgium) and its application for water management in the Sourou valley (Burkina Faso)
Rosillon, Françis ULg; Vander Borght, Paul ULg; Bado Sama, H.

in Water Science & Technology (2005), 52(9), 85-93

Inspired by the experience of a river contract in Wallonia (Belgium) since 1990, the implementation of a first river contract has been initiated in a West African country, Burkina Faso. This application ... [more ▼]

Inspired by the experience of a river contract in Wallonia (Belgium) since 1990, the implementation of a first river contract has been initiated in a West African country, Burkina Faso. This application is not limited to a simple transposition of the Walloon model. The Burkina context calls for adaptation to the local environmental and socio-economical realities with an adequate partnership management. The importance of the mobilization around this project of institutional partners, as well as local collectivities, agricultural producers and water users in general reveals the great expectations of the actors concerning this new tool of water participative management. But will the latter be equal to the task? A first assessment has been drawn up one year after the launch. During the first year of the project, a participative diagnostic was implemented but the understanding of basic notions of water management such as 'river' (not translatable in the local language), 'watershed', 'contract' were not obvious. After the identification of functions and uses of water in the basin, an environmental survey was started. This approach allows study with the river committees of the priority actions to be developed as a first project of restoration of the gallery forest alongside the stream to fight against desertification. This project of integrated and participative management of water at sub-basin level is a concrete example of solidarity and exchange know-how between North and South in the context of a sustainable development. [less ▲]

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See detail"D'un mur à l'autre", note sous l'avis de la Cour internationale de Justice du 9 juillet 2004 sur les conséquences juridiques de l'édification d'un mur dans le territoire palestinien occupé
Vincent, Philippe ULg

in Revue de la Faculté de Droit de l'Université de Liège (2005), 1

Analyse de l'avis rendu le 9 juillet 2004 sur la question de la légalité du mur de séparation construit par l'Etat d'Israêl.

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See detailWhole-system metabolism and CO2 fluxes in a Mediterranean Bay dominated by seagrass beds (Palma Bay, NW Mediterranean)
Gazeau, Frédéric; Duarte, C. M.; Gattuso, Jean-Pierre et al

in Biogeosciences (2005), 2(1), 43-60

Planktonic and benthic incubations (bare and Posidonia oceanica vegetated sediments) were performed at monthly intervals from March 2001 to October 2002 in a seagrass vegetated area of the Bay of Palma ... [more ▼]

Planktonic and benthic incubations (bare and Posidonia oceanica vegetated sediments) were performed at monthly intervals from March 2001 to October 2002 in a seagrass vegetated area of the Bay of Palma (Mallorca, Spain). Results showed a contrast between the planktonic compartment, which was on average near metabolic balance (-4.6 +/- 5.9 mmol O-2 m(-2) d(-1)) and the benthic compartment, which was autotrophic (17.6 +/- 8.5 mmol O-2 m(-2) d(-1)). During two cruises in March and June 2002, planktonic and benthic incubations were performed at several stations in the bay to estimate the whole-system metabolism and to examine its relationship with partial pressure of CO2 (pCO(2)) and apparent oxygen utilisation (AOU) spatial patterns. Moreover, during the second cruise, when the residence time of water was long enough, net ecosystem production (NEP) estimates based on incubations were compared, over the Posidonia oceanica meadow, to rates derived from dissolved inorganic carbon (DIC) and oxygen (O-2) mass balance budgets. These budgets provided NEP estimates in fair agreement with those derived from direct metabolic estimates based on incubated samples over the Posidonia oceanica meadow. Whereas the seagrass community was autotrophic, the excess organic carbon production therein could only balance the planktonic heterotrophy in shallow waters relative to the maximum depth of the bay ( 55 m). This generated a horizontal gradient from autotrophic or balanced communities in the shallow seagrass-covered areas, to strongly heterotrophic communities in deeper areas of the bay. It seems therefore that, on an annual scale in the whole bay, the organic matter production by the Posidonia oceanica may not be sufficient to fully compensate the heterotrophy of the planktonic compartment, which may require external organic carbon inputs, most likely from land. [less ▲]

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See detailInteractions Homme-Insectes : aperçu de 10 ans d'échantillonnage passif au Musée de Zoologie de Liège
Loneux, Michèle ULg

in Notes Fauniques de Gembloux (2005), 56

Le Musée et l'Institut de Zoologie de l'Université de Liège drainent des demandes en tout genre concernant les interactions et la cohabitation entre homme et animaux. Environ trois quarts des demandes ... [more ▼]

Le Musée et l'Institut de Zoologie de l'Université de Liège drainent des demandes en tout genre concernant les interactions et la cohabitation entre homme et animaux. Environ trois quarts des demandes annuelles aboutissant au Musée ont trait aux insectes. Elles émanent en majorité de particuliers, mais de plus en plus également de sociétés ou d'administrations. Notre formation de biologiste naturaliste, ayant bénéficié de l'orientation entomologique des enseignements de Ch. Jeuniaux, nous permet de rencontrer les besoins de la région et d'assurer un service d'identification et de renseignements entomologiques, en plus de la gestion des collections scientifiques du Musée de Zoologie. Du point de vue scientifique, cette forme d'échantillonnage nous a mis en présence, ces dernières années, de quelques cas intéressants. Du point de vue humain, l'impact de notre réponse est décisif sur l'attitude des gens face à l'animal rencontré, montrant par là le peu de culture entomologique du grand public et le rôle éducatif et apaisant de l'entomologiste. Du point de vue société, notre présence dans cette institution publique permet d'assumer un rôle d'expert et un rôle pédagogique, illustrés par quelques cas précis. En perspectives, cette belle aventure sera terminée en octobre 2003, l'Université ayant choisi de faire rentrer le patrimoine des collections scientifiques du Musée de zoologie dans l'Aquarium public, et de confier leur conservation au seul gestionnaire de l'Aquarium. L'avenir des collections dépend de l'intérêt que les scientifiques leur porte? [less ▲]

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See detailA PCR method for detection of bifidobacteria in raw milk and raw milk cheese: comparison with culture-based methods
Delcenserie, Véronique ULg; Bechoux, Nathalie ULg; China, Bernard et al

in Journal of Microbiological Methods (2005), 61(1), 55-67

Bifidobacteria are well known for their beneficial effects on health and are used as probiotics in food and pharmaceutical products. As they form one of the most important groups in both human and animal ... [more ▼]

Bifidobacteria are well known for their beneficial effects on health and are used as probiotics in food and pharmaceutical products. As they form one of the most important groups in both human and animal feces, their use as fecal indicator organisms in raw milk products has recently been proposed. Bifidobacteria species isolated in humans are different from those isolated in animals. It should therefore be possible to determine contamination origin (human or animal). A method of detecting the Bifidobacterium genus was developed by PCR targeting the hsp60 gene. The genus Bifidobacterium was identified by PCR amplification of a 217-bp hsp60 gene fragment. The degenerated primer pair specific to the Bifidobacterium genus used was tested for it specificity on 127 strains. Sensitivity was measured on artificially contaminated samples. Food can however be a difficult matrix for PCR testing since it contains PCR inhibitors. So an internal PCR control was used. An artificially created DNA fragment of 315 bp was constructed. The PCR detection method was tested on raw milk and cheese samples and compared with three culture-based methods, which comprised enrichment and isolation steps. The enrichment step used Brain Heart Infusion medium with propionic acid, iron citrate, yeast extract, supplemented with mupirocin (BHMup) or not (BH) and the isolation step used Columbia blood agar medium, supplemented with mupirocin (CMup) or not (C). The method using mupirocin at both enrichment and isolation steps and the PCR method performed from the culture in BHMup enrichment medium were shown to be the most efficient. No significant difference was observed in raw milk samples between PCR from BHMup and the culture-based method BHMup/CMup, while a significant difference was noticed between the same methods in raw milk cheese samples, which would favor using PCR. The results suggested that PCR on the hsp60 gene was convenient for a rapid detection of bifidobacteria in raw milk and raw milk cheese samples and that bifidobacteria always present throughout raw milk cheese production could be efficiently used as fecal indicators. [less ▲]

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See detailA mitochondrial half-size ABC transporter is involved in cadmium tolerance in Chlamydomonas reinhardtii
Hanikenne, Marc ULg; Motte, Patrick ULg; Wu, Madeline C.S. et al

in Plant Cell and Environment (2005), 28(7), 863-873

Five cadmium-sensitive insertional mutants, all affected at the CDS1 ('cadmium-sensitive 1') locus, have been previously isolated in the unicellular green alga Chlamydomonas reinhardtii. We here describe ... [more ▼]

Five cadmium-sensitive insertional mutants, all affected at the CDS1 ('cadmium-sensitive 1') locus, have been previously isolated in the unicellular green alga Chlamydomonas reinhardtii. We here describe the cloning of the Cds1 gene (8314 bp with 26 introns) and the corresponding cDNA. The Cds1 gene, strongly induced by cadmium, encodes a putative protein (CrCds1) of 1062 amino acid residues that belongs to the ATM/HMT subfamily of half-size ABC transporters. This subfamily includes both vacuolar HMT-type proteins transporting phytochelatin-cadmium complexes from the cytoplasm to the vacuole and mitochondrial ATM-type proteins involved in the maturation of cytosolic Fe/S proteins. Unlike the Delta sphmt1 cadmium-sensitive mutant of Schizosaccharomyces pombe that lacks a vacuolar HMT-type transporter, the cds1 mutant accumulates a high amount of phytochelatin-cadmium complexes. By epitope tagging, the CrCds1 protein was localized in the mitochondria. Even though mitochondria of cds1 do not accumulate important amounts of 'free' iron, the mutant cells are hypersensitive to high iron concentrations. Our data show for the first time that a mitochondrial ATM-like transporter plays a major role in tolerance to cadmium. [less ▲]

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See detailA role for external representations in architectural design ?
Decortis, F.; Safin, Stéphane ULg; Leclercq, Pierre ULg

in Gero, John; Bonnardel, Nathalie (Eds.) Proceedings of Studying Designers '05 (2005)

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See detailPersistence and dispersion of an introduced population of Alpine Newt (Triturus alpestris) in the limestone plateau of Larzac (Southern France)
Denoël, Mathieu ULg

in Revue d'Ecologie (La Terre et la Vie) (2005), 60(2), 139-148

Persistence and dispersion of an introduced population of Alpine Newt (Triturus alpestris) in the limestone plateau of Larzoc (southern France). - The study of introduced populations is interesting to ... [more ▼]

Persistence and dispersion of an introduced population of Alpine Newt (Triturus alpestris) in the limestone plateau of Larzoc (southern France). - The study of introduced populations is interesting to better understand the geographic distribution and adaptability of species in different environments. The recent finding of an Alpine Newt population (Triturus alpestris) in the limestone plateau of Larzac (Department of Herault, France) provides the opportunity to examine the success of this species in the French supra-Mediterranean environment, Indeed, this species is absent from southern France although present in a large part of France and in northern Spain. The introduction site and all water bodies within a 2.5 km radius were surveyed between spring and autumn 2003. Because of the introduction date and the life expectancy of newts, all observed individuals are descendants of the introduced animals. They persist and breed in the study site despite the coexistence with Palmate Newts (Tri-turus helveticus). Body condition decreases in summer in these two species, but was lower in Alpine Newt males than in Palmate Newt males in autumn. Alpine Newts were found in only one of the other nine ponds, indicating a 1.5 km dispersion. Few Alpine Newts were present at this site, but reproduction was effective. These results show that the Alpine Newt can survive in southern France despite the presence of other newt species, but that the dispersion speed and rate towards other ponds are low. [less ▲]

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See detailLa référence à Augustin chez Husserl
Seron, Denis ULg

in Philosophique (2005)

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See detailTHM behaviour of engineered and natural clay barriers
Collin, Frédéric ULg; Charlier, Robert ULg

in Revue Européenne de Génie Civil (2005), 9(5-6), 797-808

This paper is concerned with two problems related to deep underground storage of nuclear waste. On one hand, a small-scale laboratory experiment has allowed to heat and wet a confined swelling clay. A ... [more ▼]

This paper is concerned with two problems related to deep underground storage of nuclear waste. On one hand, a small-scale laboratory experiment has allowed to heat and wet a confined swelling clay. A thermo-hydro-mechanical modelling is proposed and discussed. On the other hand, the extent of the damaged zone produced during tunnelling in clay is discussed based on an hydromechanical modelling showing evidences of strain localisation, i.e. a fracture initiation. [less ▲]

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See detailUnified approach of coupled constitutive laws
Collin, Frédéric ULg; Laloui, Liesse; Charlier, Robert ULg

in Revue Européenne de Génie Civil (2005), 9(5-6), 713-723

A number of geomaterials constitutive models have been proposed for the coupling of the mechanical behaviour with i) multi-phase fluid flow and suction level, ii) the thermal field changes and iii) more ... [more ▼]

A number of geomaterials constitutive models have been proposed for the coupling of the mechanical behaviour with i) multi-phase fluid flow and suction level, ii) the thermal field changes and iii) more recently the chemical concentration evolution. Most of these models follow a common framework that will be first emphasised and then particularised for the 3 considered couplings. [less ▲]

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See detailTempus fugit
Havelange, Carl ULg

in Garzaniti, Mario (Ed.) Disfare Tutto (2005)

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See detailDexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells.
Robe, Pierre ULg; Nguyen-Khac, Minh-Tuan ULg; Jolois, Olivier ULg et al

in BMC Cancer (2005), 5

BACKGROUND: HSV-tk/ ganciclovir (GCV) gene therapy has been extensively studied in the setting of brain tumors and largely relies on the bystander effect. Large studies have however failed to demonstrate ... [more ▼]

BACKGROUND: HSV-tk/ ganciclovir (GCV) gene therapy has been extensively studied in the setting of brain tumors and largely relies on the bystander effect. Large studies have however failed to demonstrate any significant benefit of this strategy in the treatment of human brain tumors. Since dexamethasone is a frequently used symptomatic treatment for malignant gliomas, its interaction with the bystander effect and the overall efficacy of HSV-TK gene therapy ought to be assessed. METHODS: Stable clones of TK-expressing U87, C6 and LN18 cells were generated and their bystander effect on wild type cells was assessed. The effects of dexamethasone on cell proliferation and sensitivity to ganciclovir were assessed with a thymidine incorporation assay and a MTT test. Gap junction mediated intercellular communication was assessed with microinjections and FACS analysis of calcein transfer. The effect of dexamethasone treatment on the sensitivity of TK-expressing to FAS-dependent apoptosis in the presence or absence of ganciclovir was assessed with an MTT test. Western blot was used to evidence the effect of dexamethasone on the expression of Cx43, CD95, CIAP2 and BclXL. RESULTS: Dexamethasone significantly reduced the bystander effect in TK-expressing C6, LN18 and U87 cells. This inhibition results from a reduction of the gap junction mediated intercellular communication of these cells (GJIC), from an inhibition of their growth and thymidine incorporation and from a modulation of the apoptotic cascade. CONCLUSION: The overall efficacy of HSV-TK gene therapy is adversely affected by dexamethasone co-treatment in vitro. Future HSV-tk/ GCV gene therapy clinical protocols for gliomas should address this interference of corticosteroid treatment. [less ▲]

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See detailLa Via Mansuerisca, première cause de pollution dans les Hautes Fagnes ?
Renson, V.; Fagel, Nathalie ULg; Streel, Maurice ULg et al

in Miscellanea Faniae (2005), 8

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See detailImpact des essences sur la fertilité des sols forestiers
Carnol, Monique ULg; Degrave, Frédéric; Weissen, Franz

in Branquart, Etienne; Paquet, Jean-Yves; Claessens, Hugues (Eds.) Journée d'étude: Gestion forestière & biodiversité. Gembloux, 23 mars 2005, résumé des interventions. (2005)

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