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See detailLa place de l'analyse du condensat de l'air exhalé dans les maladies pulmonaires obstructives.
Renkin, C.; Corhay, Jean-Louis ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2008), 63(4), 193-8

The number of publications on the analysis of the exhaled breath condensate (EBC) has increased considerably over the last five years. The EBC is a new, noninvasive and inexpensive technique which ... [more ▼]

The number of publications on the analysis of the exhaled breath condensate (EBC) has increased considerably over the last five years. The EBC is a new, noninvasive and inexpensive technique which requires a minimum of cooperation on behalf of the patient. The condensate obtained consists of more than 99.99% of water vapour, to which are added various substances which reflect the inflammatory status of the airways. It is now especially used to characterize the inflammatory state of chronic respiratory diseases such as asthma and COPD. This article describes the technique and reviews the main data from the current literature. [less ▲]

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See detailPredicting gene essentiality from expression patterns in Escherichia coli
Irrthum, Alexandre ULg; Wehenkel, Louis ULg

(2008)

Essential genes are genes whose loss of function causes lethal- ity. In the case of pathogen organisms, the identification of these genes is of considerable interest, as they provide targets for the ... [more ▼]

Essential genes are genes whose loss of function causes lethal- ity. In the case of pathogen organisms, the identification of these genes is of considerable interest, as they provide targets for the development of novel antibiotics. Computational analyses have revealed that the posi- tions of the encoded proteins in the protein-protein interaction network can help predict essentiality, but this type of data is not always avail- able. In this work, we investigate prediction of gene essentiality from expression data only, using a genome-wide compendium of expression patterns in the bacterium Escherichia coli, by using single decision trees and random forests. We first show that, based on the original expression measurements, it is possible to identify essential genes with good accu- racy. Next, we derive, for each gene, higher level features such as average, standard deviation and entropy of its expression pattern, as well as fea- tures related to the correlation of expression patterns between genes. We find that essentiality may actually be predicted based only on the two most relevant ones among these latter.We discuss the biological meaning of these observations. [less ▲]

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See detailComment j'explore...une pathologie pleurale?
Duysinx, Bernard ULg; Corhay, Jean-Louis ULg; Nguyen Dang, Delphine ULg et al

in Revue Médicale de Liège (2008), 63(10), 615-23

Pleural involvements are common and various respiratory diseases including inflammatory, infectious, occupational, or neoplastic pathological entities...Pleural thickening and pleurisy are usual ... [more ▼]

Pleural involvements are common and various respiratory diseases including inflammatory, infectious, occupational, or neoplastic pathological entities...Pleural thickening and pleurisy are usual radiological presentation. Etiological diagnosis imposes a vast and sometimes difficult exploration and it, especially since the conventional imaging by radiology, ultrasound, scanning and nuclear magnetic resonance has no specific diagnostic criteria for pleural malignancy. The metabolic imaging by positron emission tomography (PET) has been gradually positioned in the decision-making algorithm exploration of the pleural disease due to its excellent sensitivity in the diagnosis of malignant pleurisy (88.8%-100%). The analysis of chemistry, bacteriology and cytology pleural fluid makes a significant contribution to the diagnostic approach. However, although inescapable, thoracocentesis has a diagnostic sensibility not exceeding 62%. Moreover, the sensibility of the pleural blind needle biopsies does not exceed 51%. So, thoracoscopy, more invasive, is often justified to precise pleural disease with a diagnostic sensitivity greater than 95%. Finally, despite the diagnostic arsenal available, over 10% of pleurisies remain unknown etiology. [less ▲]

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See detailEstimation de densité par ensemble aléatoire de poly-arbres
Ammar, Sourour; Leray, Philippe; Wehenkel, Louis ULg

(2008)

La notion de mélange de modèles simples aléatoires est de plus en plus utilisée et avec succès dans la littérature de l’apprentissage supervisé ces dernières années. Parmi les avantages de ces méthodes ... [more ▼]

La notion de mélange de modèles simples aléatoires est de plus en plus utilisée et avec succès dans la littérature de l’apprentissage supervisé ces dernières années. Parmi les avantages de ces méthodes, citons l’amélioration du passage à l’échelle des algorithmes d’apprentissage grâce à leur aspect aléatoire et l’amélioration de l’exactitude de la prédiction des modèles induits grâce à une flexibilité plus élevée en ce qui concerne le compromis biais/variance. Dans le présent travail, nous proposons d’explorer cette idée dans le contexte de l’estimation de la densité. Nous proposons une nouvelle famille de méthodes d’apprentissage non-supervisé à base de mélange de grands ensembles aléatoires de poly-arbres. La caractéristique spécifique de ces méthodes est leur passage à l’échelle, aussi bien en terme de nombre de variables que de données à traiter. Cette étude, exploratoire, compare empiriquement ces méthodes sur un ensemble de problèmes de test discrets de taille et de complexité croissantes et ouvre de nombreuses perspectives auxquelles nous prévoyons de nous intéresser. [less ▲]

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See detailNew challenges for feature selection in data mining and knowledge discovery
Saeys, Yvan; Liu, Huan; Inza, Inaki et al

in Journal of Machine Learning Research (2008), 4

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See detailIn Vitro Detection And Characterization Of Bacteriocin-Like Inhibitory Activity Of Lactic Acid Bacteria (Lab) Isolated From Senegalese Local Food Products
Diop, Mb.; Dubois Dauphin, Robin ULg; Dortu, C. et al

in African Journal of Microbiology Research [=AJMR] (2008), 2(8),

The prevalence of lactic acid bacteria (LAB) in Senegalese local food products was determined to be 109 CFU/g in millet flour and milk products, and 103 CFU/g in seafood products. These food products are ... [more ▼]

The prevalence of lactic acid bacteria (LAB) in Senegalese local food products was determined to be 109 CFU/g in millet flour and milk products, and 103 CFU/g in seafood products. These food products are generally preserved by spontaneous fermentation (without addition of starters). Of 220 lactic acid bacteria strains randomly selected from such products, 12 isolates capable of producing bacteriocin-like substances (bac+) were detected. Based on the use of API 50 CH test kits and 16S rDNA sequencing, 11 isolates were characterized as Lactococcus lactis subsp. lactis strains and one as an Enterococcus faecium strain. Nisin- and enterocin B-encoding genes were respectively identified in the bac+ lactococcal strains and the E. faecium strain. Since the bac+ Lc. lactis strains were isolated from different products, it suggests a high potential of growth by these strains in variable ecological environments. Expression of the nisin gene was indicated for one of the lactococcal strains, designated Lc. lactis subsp. lactis CWBI-B1410, which showed the highest in vitro antibacterial activity. An antibacterial preparation prepared from the CWBI-B1410 strain showed many similarities with nisin with regards to its inhibitory effects, heat resistance, protease sensitivity profile, as well as retention time of the antibacterial substances on a C18 column. These results suggest that a nisin-like substance is produced by the CWBI-B1410 strain. This strain has been selected for application as an additional barrier to supplementation with sodium chloride as a means to improve the bacterial quality of fish commodities in Senegal. [less ▲]

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See detailLes lipases sont des hydrolases atypiques : principales caractéristiques et applications
Fickers, Patrick ULg; Destain, Jacqueline ULg; Thonart, Philippe ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2008), 12(2), 119-130

Due to their kinetic and substrate specificities, triacylglycerol acyl-hydrolases or lipases are atypical enzymes. In function of their microenvironment, lipases are able to act as hydrolases in aqueous ... [more ▼]

Due to their kinetic and substrate specificities, triacylglycerol acyl-hydrolases or lipases are atypical enzymes. In function of their microenvironment, lipases are able to act as hydrolases in aqueous solution or as biocatalysts in organic synthesis. As hydrolases, they are responsible of the triglycerids catabolism into fatty acids and glycerol. In many organisms, this reaction plays a major role in the fat and lipid metabolism. In addition, lipases are also able to hydrolyse phospholipids and cholesterol esters. In organic solvent, lipases could catalyse reactions such as esterifications, acidolysis or alcoolysis with enantio-, regio- and chimioselectivity. Lipases form a mixed class of enzyme due to their animal, vegetal or microbial origins. All those properties led to the development of many applications in the food and chemical industries but also in the medical and therapeutic field. [less ▲]

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See detailRestauration des potentialités de sols dégradés à l’aide du zaï et du compost dans le Yatenga (Burkina Faso)
Sawadogo, H.; Bock, Laurent ULg; Lacroix, D. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2008), 12(3),

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See detailAugmentation osseuse sous-sinusienne : actualisation du concept du sinus lift.
Lambert, France ULg; Lecloux, Geoffrey ULg; Rompen, Eric ULg

in Revue d'Odonto-Stomatologie (2008), 37(1), 3-17

L’élévation du plancher sinusal est une technique permettant de placer des implants d’une longueur suffisante au niveau du maxillaire postérieur. Depuis qu’elle a été initialement décrite dans les années ... [more ▼]

L’élévation du plancher sinusal est une technique permettant de placer des implants d’une longueur suffisante au niveau du maxillaire postérieur. Depuis qu’elle a été initialement décrite dans les années 80, cette technique a beaucoup évolué. A l’heure actuelle, on peut considérer cette approche comme prédictible, simple et réalisable au fauteuil sous anesthésie locale. Cet article vise d’abord à expliciter clairement le phénomène biologique du « sinus-lift », ensuite, de décrire le protocole chirurgical que nous appliquons à l’Université de Liège (Belgique) et de le confronter avec la littérature scientifique existante. [less ▲]

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See detailDe onzin van het vanzelfsprekende beeld
Meesters, Gert ULg

in Freespace Nieuwzuid (2008), (31), 47-56

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See detailLes messicoles, fleurs des moissons
Legast, Marie ULg; Mahy, Grégory ULg; Bodson, Bernard ULg

Book published by Claude Delbeuck/Direction générale de l'Agriculture (2008)

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See detailThe dilemmas for a sustainable food sector
Mormont, Marc ULg; Stassart, Pierre M ULg

in Stassart, Pierre M (Ed.) Proceedings of the International Confernce (2008)

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See detailLes sables mouvants de la recherche action comme terrain géographique
Schmitz, Serge ULg

in A travers l’espace de la méthode : les dimensions du terrain en géographie : Université d'Artois, 18-20 juin 2008 (2008)

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See detailChemical Characterization Of Cuticular Extracts Of Sitobion Avenae (Hemiptera : Aphididae)
Muratori, Frédéric; Hance, Thierry; Lognay, Georges ULg

in Annals of the Entomological Society of America (2008), 101(3), 598-603

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See detailIntérêt de la troponine sérique en tant que marqueur d’une atteinte du myocarde en médecine vétérinaire
Sandersen, Charlotte ULg; Remy, Benoit; Olejnik, Dorine ULg et al

in Annales de Médecine Vétérinaire (2008)

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See detailWeathering in the Lake Baikal watershed during the Kazantsevo (Eemian) interglacial: Evidence from the lacustrine clay record
Fagel, Nathalie ULg; Mackay, Anson W

in Palaeogeography, Palaeoclimatology, Palaeoecology (2008), 259(2-3), 244-257

The clay-mineralogical record of a piston core recovered on an elevated plateau in the northern basin of Lake Baikal has been investigated for the Kazantsevo interglacial period (i.e., Eemian s.s ... [more ▼]

The clay-mineralogical record of a piston core recovered on an elevated plateau in the northern basin of Lake Baikal has been investigated for the Kazantsevo interglacial period (i.e., Eemian s.s. equivalent in northern Europe). The age model (as inferred from palaeomagnetic intensity) suggests that this stage spans ca. 128 to 117 kyr BP. Relative clay mineral abundances and clay-mineral ratios are used to reconstruct the weathering conditions within the Baikal watershed at a sub-millennial resolution, and suggest that the clay record is highly variable. A bimodal clay-data distribution is in agreement with different clay sources and/or formation between the studied glacial and interglacial periods. High amounts of smectites in the Taz glacial samples (128.7-136.4 kyr BP) may be explained by an additional source of neoformed smectites during the glacial stage. In addition to the classically used smectite/illite ratio, the mineralogical results are integrated by the calculation of a hydrolysis index that takes into account the abundance of all clay species and their sensitivity to chemical weathering. A principal components analysis (PCA) of the Baikal clay minerals allows the comparison of the clay parameters with regard to weathering conditions. Clay data are further compared (i) with diatom and pollen profiles, (ii) with pollen-based quantitative reconstructions for the same core material, and (iii) with other climate reconstructions for the Lake Baikal region and Siberia. Several features of our record are highlighted here. During the early period of the Kazantsevo interglacial (128.4-125.2 kyr BP), weathering processes remain controlled by physical reworking for more than 2 kyr after the initial transition from cold to warm conditions. Inception of chemical weathering starts only after ca. 125 kyr BP, a period coincident with the warmest conditions according to both the pollen record and by the strongest chernozem development in Siberian soils. Within the interglacial interval, the hydrolysis index displays a two-step increase, punctuated by a minimum value ca. 122 kyr BP. The increasing but irregular trend persists after the transition from the Kazantsevo interglacial to the Zyryanka glacial (similar to 117 kyr BP). Peak chemical weathering, as inferred by clay changes, lags the interglacial/ glacial transition by at least 2 kyr. This suggests that pedogenesis remains active after the interval of surface stabilization. Lake Baikal clay minerals trace the nature of the main weathering conditions within the watershed. We note any increase in physical weathering is rapidly recorded in sedimentary clay assemblages but the mineral imprint to chemical weathering changes is more gradual, lagging reconstructed climate conditions over the lake by ca. 2 kyr. 0 2007 Elsevier B.V.. All rights reserved. [less ▲]

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See detailAssembly and concept of a web-based GIS within the paleolimnological project CONTINENT (Lake Baikal, Russia)
Heim, Birgit; Klump, Jens; Oberhaensli, Hedi et al

in Journal of Paleolimnology (2008), 39(4), 567-584

Web-based Geographical Information Systems (GIS) are excellent tools within interdisciplinary and multi-national geoscience projects to exchange and visualize project data. The web-based GIS presented in ... [more ▼]

Web-based Geographical Information Systems (GIS) are excellent tools within interdisciplinary and multi-national geoscience projects to exchange and visualize project data. The web-based GIS presented in this paper was designed for the paleolimnological project 'High-resolution CONTINENTal paleoclimate record in Lake Baikal' (CONTINENT) (Lake Baikal, Siberia, Russia) to allow the interactive handling of spatial data. The GIS database combines project data (core positions, sample positions, thematic maps) with auxiliary spatial data sets that were downloaded from freely available data sources on the world wide web. The reliability of the external data was evaluated and suitable new spatial datasets were processed according to the scientific questions of the project. GIS analysis of the data was used to assist studies on sediment provenance in Lake Baikal, or to help answer questions such as whether the visualization of present-day vegetation distribution and pollen distribution supports the conclusions derived from palynological analyses. The refined geodata are returned back to the scientific community by using online data publication portals. Data were made citeable by assigning persistent identifiers (DOI) and were published through the German National Library for Science and Technology (TIB Hannover, Hannover, Germany). [less ▲]

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See detailClay-mineral record in Lake Baikal sediments: The Holocene and Late Glacial transition
Fagel, Nathalie ULg; Boes, Xavier

in Palaeogeography, Palaeoclimatology, Palaeoecology (2008), 259(2-3), 230-243

We analyse the clay-mineralogical composition of two 1-m long cores from elevated plateaus in the southern and northern basins of Lake Baikal. Our aim is to test the limits of classically used clay ... [more ▼]

We analyse the clay-mineralogical composition of two 1-m long cores from elevated plateaus in the southern and northern basins of Lake Baikal. Our aim is to test the limits of classically used clay proxies for climate reconstructions. Mineralogical signature is determined by X-ray diffraction on oriented aggregates from Holocene and Late Glacial sediments. Mineralogical results are presented on a palaeomagnetic-derived time scale. Sampling at a centimeter resolution allows for a sub-millenial order reconstruction. The evolution of clay-derived climate proxies (smectite/illite peak intensity ratio, S/I) is compared between the two locations, with respect to other climate reconstructions for the Lake Baikal area and Siberia. During the Late Glacial punctual increases of S/I are related to changes of particle source rather than any climate change. At both sites the most intense chemical weathering conditions occured during the Subboreal, lagging the Eurasian middle Atlantic climate optimum. S/I follows a gradual but irregular increase through the Holocene, probably related to slow warming favourable to the development of the Siberian soils. The different sensitivity to hydrolysing conditions in northern and southern sites can be explained by a combination of local lithological and topographical parameters. (c) 2007 Elsevier B.V. All rights reserved. [less ▲]

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See detailThe diet of the serotine bat: A Comparison between rural and urban environments
Kervyn, Thierry; Libois, Roland ULg

in Belgian Journal of Zoology (2008), 138(1), 41-49

The diet of four maternity colonies of serotine bats in Southern Belgium was investigated by analysing faecal pellets collected from beneath the roost throughout the activity season. Their diet is ... [more ▼]

The diet of four maternity colonies of serotine bats in Southern Belgium was investigated by analysing faecal pellets collected from beneath the roost throughout the activity season. Their diet is composed of Coleoptera Melolonthidae (Melolontha sp., Amphimallon sp., Rhizotrogus sp., Serica brunnea), Coleoptera Scarabaeidae (Aphodius sp., Geotrupes sp.), Coleoptera Carabidae, Diptera Tipulidae, Diptera Chironomidae, Lepidoptera, Hemiptera Pentatomidae, Hymenoptera Ichneumonoidea Ophionidae, Trichoptera and Arachnida. <br />The diet of an urban colony of serotine bats was broadly the same as the diets of three rural colonies. Though some qualitative and quantitative variations were observed between study sites, the main source of variation in the diet was the seasonal availability of potential prey. <br />The prominence of agriculture-dependant prey (chafers in mid summer and Aphodius beetles in late summer and autumn) was observed at all study sites. Consequently, dietary breadth and diversity is smaller during these periods. [less ▲]

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