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See detailUsefulness of F-18-FDG PET in the post-therapy surveillance of endometrial carcinoma
Belhocine, Tarik; De Barsy, Caroline; Hustinx, Roland ULg et al

in European Journal of Nuclear Medicine and Molecular Imaging (2002), 29(9), 1132-1139

The aim of this study was to assess the usefulness of fluorine-18 tluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) in the post-therapy surveillance of endometrial carcinomas. Forty-one ... [more ▼]

The aim of this study was to assess the usefulness of fluorine-18 tluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) in the post-therapy surveillance of endometrial carcinomas. Forty-one fully corrected whole-body PET studies were performed in 34 women with previously treated endometrial cancers as a part of their follow-up programme. In 28 studies, FDG PET was indicated to localise a recurrence suspected at the control visits on the basis of clinical examination and/or radiological abnormalities (chest X-ray, CT or MRI) and/or elevated tumour marker levels (CA125, CEA). Another 13 studies were performed as a simple surveillance procedure. Overall, in 26 studies PET detected recurrent disease, which was confirmed either by histology (n=7) or by clinical and radiological outcomes (n=19). In 88% of the cases, the PET findings confirmed recurrence suggested by routine follow-up. In the remaining 12% of cases, PET detected asymptomatic recurrences that were unsuspected at the control visits. Whole-body PET accurately localised the site of confirmed recurrences as being above and below the diaphragm in 50%, only below the diaphragm in 35% and only above the diaphragm in 15%. In one patient, however, PET missed microscopic lung metastases shown on thoracic CT, and in three studies, metabolic imaging results were not confirmed. In I I of 12 negative PET studies, no subsequent clinical or radiological recurrences were observed with a median follow-up of 10 months. Overall, the results of PET agreed well with the final diagnosis (Cohen's kappa coefficient =0.78). In 9/26 patients (35%) with confirmed recurrences, the PET findings significantly altered the treatment choice by detecting either clinically or radiologically unsuspected distant metastases. The sensitivity, specificity, diagnostic accuracy and positive and negative predictive values of FDG PET imaging in the post-therapy surveillance of endometrial carcinomas were 96%, 78%, 90%, 89% and 91 %, respectively. Indeed, the high likelihood ratio for a positive test result (4.5) and the low likelihood ratio for a negative test result (0.05) demonstrated the clinical utility of metabolic imaging in "ruling in" disease as well as "ruling out" recurrence. In conclusion, whole-body FDG PET appears useful in the post-therapy surveillance of endometrial cancers, both for the accurate localisation of suspected recurrences and for the detection of asymptomatic recurrent disease. [less ▲]

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See detailProgress in microscopic modeling of damage in steel at high temperature
Remy, M.; Castagne, Sylvie; Habraken, Anne ULg

in International Journal of Forming Processes (2002), 5(N°2-3-4/2002), 445-455

With the goal to study crack propagation in continuous casting, this paper presents an on going project to develop and identify a mathematical finite element model of damage in steel at high temperature ... [more ▼]

With the goal to study crack propagation in continuous casting, this paper presents an on going project to develop and identify a mathematical finite element model of damage in steel at high temperature. A representative microscopic cell of the material is presented and adapted to available chemical information, precipitation state and micro-structures observed using metallographic as weel as imaging methods (optical microscopy, SEM, orientation imaging microscopy). Compression tests of cylindrical samples after a thermal treatment have been performed to identify the parameters of an elasto-visco-plastique law of Norton-Hoff type. Hot damage tests in tensile and compression states help to provide information on crack appearance. [less ▲]

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See detailMicro-macro analysis of steel sheet behaviour in finite element simulations. Application to deep-drawing process.
Duchene, Laurent ULg; Godinas, A.; Cescotto, Serge ULg et al

in Cescotto, Serge (Ed.) Proceedings of the Sixth European Mechanics of Materials Conference (EMMC6) Non Linear Mechanics of Anisotropic Materials (2002, September)

This paper presents a constitutive law based on Taylor’s model implemented in our non-linear finite element code LAGAMINE. The yield locus is only locally described and a particular interpolation method ... [more ▼]

This paper presents a constitutive law based on Taylor’s model implemented in our non-linear finite element code LAGAMINE. The yield locus is only locally described and a particular interpolation method has been developed. This local yield locus model uses a discrete representation of the material’s texture. The interpolation method is presented and a deep-drawing application is simulated in order to show up the influence of the texture evolution during forming processes. [less ▲]

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See detailProposition d'une méthode d'inventaire des dégâts frais de cervidés applicable en Région wallonne : les dégâts d'écorcement
Lejeune, Philippe ULg; Rotheudt, H.; Verrue, V.

in Forêt Wallonne (2002), (60), 4-10

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See detailComputation of simultaneous available transfer capability under thermal and voltage security constraints
Capitanescu, Florin ULg; Van Cutsem, Thierry ULg

(2002, September)

This paper proposes a method to compute the Available Transfer Capability (ATC) of a power system under both thermal and voltage security constraints. The objective is to determine, in some optimal manner ... [more ▼]

This paper proposes a method to compute the Available Transfer Capability (ATC) of a power system under both thermal and voltage security constraints. The objective is to determine, in some optimal manner, the ATC of several simultaneous transactions, such that any postulated contingency does not cause voltage instability nor thermal overloads. Thermal constraints are derived for every branch likely to be overloaded in post-contingency states. Voltage security constraints are derived from voltage unstable post-contingency scenario, obtained by Quasi Steady- State simulation, a fast time-domain method. The paper also addresses the discrimination problem, i.e. the fact that the computed ATC might favor some trades to the detriment of others. Variants will be discussed to deal with such situations. The method is illustrated on an 80-bus test system. [less ▲]

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See detailLe cinéma d’animation et ses thanatomorphoses (fragments sur le monstre, la charogne, le montage et l’animation)
Tomasovic, Dick ULg

in Cinémas : revue d'études cinématographiques / Cinémas: Journal of Film Studies (2002), 13(Automne), 143-164

The role and limits of editing in animation film are reconsidered here. It is no longer a matter of perceiving this practice as “simply” assembling shots, associating random elements, linking diverse ... [more ▼]

The role and limits of editing in animation film are reconsidered here. It is no longer a matter of perceiving this practice as “simply” assembling shots, associating random elements, linking diverse pieces and creating a monstrous body, but rather, it is presently regarded as a continual process of managing transitions, shifting between images, transforming inanimate objects, transmuting immobile elements and transfiguring inert beings. Thus, the animation film’s purpose is less phantasmal, to be a giver of life, as it is phantasmagoric, to be an animator of death. [less ▲]

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See detailDemographic and clinical parameters influencing the short-term outcome of anti-tumor necrosis factor (infliximab) treatment in Crohn's disease
Vermeire, S.; Louis, Edouard ULg; Carbonez, A. et al

in American Journal of Gastroenterology (2002), 97(9), 2357-2363

OBJECTIVE: Infliximab is an effective treatment for refractory or fistulizing Crohn's disease (CD). However, about 30% of patients do not respond to infliximab for unknown reasons. Identifying predictive ... [more ▼]

OBJECTIVE: Infliximab is an effective treatment for refractory or fistulizing Crohn's disease (CD). However, about 30% of patients do not respond to infliximab for unknown reasons. Identifying predictive factors of response is important for optimizing clinical management and for better understanding infliximab's mechanisms of action. The aim of this study was to assess whether demographic or clinical parameters influence short-term response to infliximab. METHODS: The first 240 CD patients of the Belgian Infliximab Expanded Access Program were studied for response to infliximab treatment and assessed at 4 (refractory luminal CD) or 10 wk (fistulizing CD) after the first infusion. Detailed demographic and clinical information on age, sex, type of disease (fistulizing or refractory), Crohn's Disease Activity Index score, C-reactive protein (CRP), smoking habits, disease duration, localization of disease, concomitant medication, and previous surgery were obtained from all patients. Logistic regression and decision tree analysis were performed. RESULTS: There were 73.5% responders and 26.5% nonresponders to treatment. Stepwise logistic regression identified age (OR = 0.971, 95% CI = 0.947-0.995, p = 0.018), isolated ileitis (OR = 0.359, 95% CI 0.177-0.728, p = 0.004), and previous surgery (OR 0.429, 95% CI = 0.233-0.787, p = 0.006) as inversely correlated with response, whereas isolated colitis (OR = 1.905, 95% CI = 1.010-3.597, p = 0.046) and concomitant immunosuppressive treatment (OR = 2.670, 95% CI = 1.430-5.016, p = 0.0022) were positively correlated with response to infliximab. Surprisingly, smoking habits were not retained as predictors for response. Decision tree analysis provided a working algorithm based on age and immunosuppressive treatment that warrants further exploration. CONCLUSIONS: In this large cohort of infliximab-treated CD patients, young age, Crohn's colitis, and concomitant immunosuppressive treatment were identified as independent variables favoring short-term response to infliximab. [less ▲]

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See detailLes paysages
Melin, Eric ULg; Feltz, Claude ULg; Droeven, Emilie ULg et al

Report (2002)

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See detailLe patrimoine naturel
Feltz, Claude ULg; Guillitte, Olivier ULg; Van Der Kaa, Claire ULg et al

Report (2002)

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See detailComparaison de différents types de compostages de matières organiques diverses non valorisées par les paysans au Rwanda
Culot, Marc ULg; Mbonigaba Muhinda, Jean-Jacques; Maniraguha, J. D.

in Etudes Rwandaises : Série sciences exactes, naturelles et appliquées (2002), 5

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See detailEffets de divers types de matières organiques en comparaison avec une fertilisation minérale sur les propriétés et la production d'un sol acide au Rwanda
Culot, Marc ULg; Mbonigaba Muhinda, Jean-Jacques; Bizimara, R.

in Etudes Rwandaises (2002), 5

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See detailSystematic regularization of linear inverse solutions of the EEG source localization problem
Phillips, Christophe ULg; Rugg, Michael D; Friston, Karl J

in NeuroImage (2002), 17(1), 287-301

Distributed linear solutions of the EEG source localization problem are used routinely. Here we describe an approach based on the weighted minimum norm method that imposes constraints using anatomical and ... [more ▼]

Distributed linear solutions of the EEG source localization problem are used routinely. Here we describe an approach based on the weighted minimum norm method that imposes constraints using anatomical and physiological information derived from other imaging modalities to regularize the solution. In this approach the hyperparameters controlling the degree of regularization are estimated using restricted maximum likelihood (ReML). EEG data are always contaminated by noise, e.g., exogenous noise and background brain activity. The conditional expectation of the source distribution, given the data, is attained by carefully balancing the minimization of the residuals induced by noise and the improbability of the estimates as determined by their priors. This balance is specified by hyperparameters that control the relative importance of fitting and conforming to prior constraints. Here we introduce a systematic approach to this regularization problem, in the context of a linear observation model we have described previously. In this model, basis functions are extracted to reduce the solution space a priori in the spatial and temporal domains. The basis sets are motivated by knowledge of the evoked EEG response and information theory. In this paper we focus on an iterative "expectation-maximization" procedure to jointly estimate the conditional expectation of the source distribution and the ReML hyperparameters on which this solution rests. We used simulated data mixed with real EEG noise to explore the behavior of the approach with various source locations, priors, and noise levels. The results enabled us to conclude: M Solutions in the space of informed basis functions have a high face and construct validity, in relation to conventional analyses. (ii) The hyperparameters controlling the degree of regularization vary largely with source geometry and noise. The second conclusion speaks to the usefulness of using adaptative ReML hyperparameter estimates. (C) 2002 Elsevier Science (USA). [less ▲]

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See detailTumor cell and stromal cell interactions during breast cancer progression
Noël, Agnès ULg; Foidart, Jean-Michel ULg

in Journal of Molecular Medicine (2002, September)

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See detailApplying the electronic nose in the environment : requirements for the sensors
Nicolas, Jacques ULg; Romain, Anne-Claude ULg; Andre, Philippe ULg

in Szuber, Jacek (Ed.) Papers from the 3rd international seminar on semiconductor gas sensors-SGS 2002, Ustron, Poland, 19-22 september 2002 (2002, September)

For few years, the department "Environmental monitoring" at FUL applies the principle of the electronic nose equipped with tin oxide sensors to recognise and to monitor real life malodours in the ... [more ▼]

For few years, the department "Environmental monitoring" at FUL applies the principle of the electronic nose equipped with tin oxide sensors to recognise and to monitor real life malodours in the environment and directly in the field. <br />For such emissions, the gas mixtures are very complex and only their odour should be of interest, and not their chemical composition. <br />Moreover, working in the field implies various constraints. <br />The obstacles of the monitoring of real life environmental odours with an electronic nose can be classified into three main areas : the final goal of the study (measuring an odorous annoyance), the analysed sample itself (influenced by the evolution of the process and of ambient parameters) and the operating conditions (necessity to transport the reference gas and the batteries in the field, influence of air humidity). <br />The paper describes the approach of FUL to the problem with various tests conducted in the field with home-made electronic noses based on tin oxide sensors and with very simple configurations. The conclusions, which can be extrapolated to any other sensor types, are promising, but the sensor performances (sensibility, reproducibility, electrical consumption, drift, etc.) should still be improved before reaching the final goal. [less ▲]

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See detailA diagnostic m-test for distributional specification of parametric conditional heteroscedasticity models for financial data
Lejeune, Bernard ULg

Conference (2002, August 26)

This paper proposes a convenient and generally applicable diagnostic m-test for checking the distributional specification of parametric conditional heteroscedasticity models for financial data such as the ... [more ▼]

This paper proposes a convenient and generally applicable diagnostic m-test for checking the distributional specification of parametric conditional heteroscedasticity models for financial data such as the customary student-t GARCH Model. The proposed test is based on the moments of the probability integral transform of the estimated innovations of the assumed model. Monte-Carlo evidence indicates that our suggested test performs well both in terms of size and power. [less ▲]

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See detailOxytocin synthesis and oxytocin receptor expression by cell lines of human small cell carcinoma of the lung stimulate tumor growth through autocrine/paracrine signaling
Pequeux, Christel ULg; Breton, Christophe; Hendrick, Jean-Claude et al

in Cancer Research (2002), 62(16), 4623-4629

The objective of the present work was to investigate the existence of an oxytocin (OT)-mediated autocrine/paracrine signaling upon small cell carcinoma of the lung (SCCL) cell growth. In that view, OT ... [more ▼]

The objective of the present work was to investigate the existence of an oxytocin (OT)-mediated autocrine/paracrine signaling upon small cell carcinoma of the lung (SCCL) cell growth. In that view, OT receptor (OTR) expression, concomitant with OT synthesis and secretion, was evidenced on three different SCCL cell lines (DMS79, H146, and H345) and related to the vasopressin (VP) system. Specific OT, VP, OTR, Via VP receptor (V1aR), and V1b/V3 VP receptor (V1bR/V3R) transcripts were identified by reverse transcription-.PCR in all cell lines studied. Binding of I-125-(d(CH2)(5)(1),Tyr(Me)(2), Thr(4), Orn(3),Tyr(9)-NH2)-vasotocin (OVTA) was observed on all SCCL cell lines, with a K-d (dissociation constant) ranging from 0.025-0.089 nm, depending; on the cell line and the analytical method. Selectivity of I-125-OVTA binding was confirmed by displacement curves obtained with various OTR and VP receptor agonists and antagonists (OT, OVTA, L-371,257, VP, F180). Immunocytochemistry identified cellular OT and VP, and peptide secretion was measured in supernatants of SCCL cultures. [H-3]Thymidine incorporations, applied on H345 cells, demonstrated a dose-dependent mitogenic effect of exogenous OT (1 and 100 nM) that was abolished by the OTR antagonist OVTA. A decrease of proliferation was also observed with OVTA alone, showing a functional mitogenic effect of tumor-derived OT. Taken together, these observations demonstrate the existence of a functional OT-mediated autocrine/paracrine signaling actively implicated in growth and development of SCCL tumors. Furthermore, these findings point to the potential of OT antagonists for development as therapeutic agents for the treatment of SCCL. [less ▲]

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See detailpH Dependence of the morphology of aqueous micelles formed by polystyrene-block-poly(2-vinylpyridine)-block-poly(ethylene oxide) copolymers
Gohy, Jean-François; Willet, Nicolas ULg; Varshney, Sunil K et al

in e-Polymers (2002), (35), 1-10

The morphology of micelles formed by two polystyrene-block-poly(2-vinylpyridine)- block-poly(ethylene oxide) (PS-b-P2VP-b-PEO) copolymers was studied in water by dynamic light scattering and transmission ... [more ▼]

The morphology of micelles formed by two polystyrene-block-poly(2-vinylpyridine)- block-poly(ethylene oxide) (PS-b-P2VP-b-PEO) copolymers was studied in water by dynamic light scattering and transmission electron microscopy. Spherical micelles were observed that consist of a PS core, a P2VP shell and a PEO corona. The characteristic size of core, shell and corona depends on the copolymer composition. An important increase in micellar size occurs at pH < 5 as a result of P2VP block protonation. The reversibility of this pH effect depends on copolymer composition, too. The conformation of the PEO block plays an important role in this pH driven morphological transition. [less ▲]

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See detailCampagne de mesure des odeurs sur le CET "Champ de Beaumont" à Monceau-sur-Sambre Estimation des nuisances olfactives Jacques NICOLAS – Anne-Sophie CHAPLAIN F.U.L. Arlon 12 Août
Nicolas, Jacques ULg; Chaplain, Anne-Sophie

Report (2002)

The study is made in the frame of a follow-up monitoring of all landfill sites in Wallonia, initiated by the Ministry of Environment and managed by ISSeP. The research group applied a field inspection ... [more ▼]

The study is made in the frame of a follow-up monitoring of all landfill sites in Wallonia, initiated by the Ministry of Environment and managed by ISSeP. The research group applied a field inspection technique based on the perception of a panel of experts sniffing the air around the region of interest and trying to delineate the odour plume. In a second step, the recorded meteorological data are entered into an atmospheric dispersion model and the odour emission rate of the facility is adjusted until the predicted odour impact zone fits about exactly the one which is measured in the field. The present report concerns the site of Monceau-sur-Sambre. [less ▲]

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