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See detailQuatre siphonaptères (Siphonaptera) nouveaux pour la faune de Belgique
Libois, Roland ULg

in Bulletin de la Société royale belge d'Entomologie (2009), 145

This short note reports the circumstances where four fleas species, not yet publishid in Belgium, where recorded

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See detailMouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production
Guéders, Maud ULg; Paulissen, Geneviève ULg; Crahay, Céline et al

in Inflammation Research (2009), 58(12), 845-54

Objective Animal models of asthma mimic major features of human disease. Since the genetic background of experimental animals might affect hyperresponsiveness and inflammation, we studied its potential ... [more ▼]

Objective Animal models of asthma mimic major features of human disease. Since the genetic background of experimental animals might affect hyperresponsiveness and inflammation, we studied its potential influence and the mechanisms leading to differences in strains. Methods We applied a mouse model of allergic asthma to BALB/c and C57BL/6 mice. Results BALB/c mice displayed greater levels of airway reactivity to methacholine than C57BL/6 mice. Moreover, BALB/c mice exhibited higher numbers of mast cells in lung tissue when compared to C57BL/6. On the contrary, eosinophil and neutrophil counts in bronchoalveolar lavage fluid (BALF) as well as peribronchial eosinophilia were greater in C57BL/6. IL (Interleukin)-4, IL-5, IL-13, and CCL11 levels measured in whole-lung extracts were higher in BALB/c, while, in sharp contrast, CCL11 and CCL5 levels were higher in BALF of C57BL/6 mice. Conclusions We observed phenotypic differences between C57BL/6 and BALB/c mice in an asthma model with different distributions of pro-inflammatory cytokines and inflammatory cells. [less ▲]

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See detailAllergie au venin d'hyménoptère et tests de laboratoires : de nouvelles approches pour la prise en charge des patients à haut risque de réaction sévère
Gadisseur, Romy ULg; Cataldo, Didier ULg; Collard, Laurence ULg et al

in Revue Médicale de Liège (2009), 64(11), 570-5

The consequences of Hymenoptera venom anaphylaxis are very severe but it is not obvious to predict which reactions will occur in one single patient when he is stung for the second time. For a couple of ... [more ▼]

The consequences of Hymenoptera venom anaphylaxis are very severe but it is not obvious to predict which reactions will occur in one single patient when he is stung for the second time. For a couple of years, many new laboratory tests have been experimented and many studies published. CAST, BAT, WB, tryptase, sIgE and sIgG4 are the new valuable additional diagnostic tools that can help the decision to perform an immunotherapy or to discontinue this therapy after 3 years. The aim of our study was to determine which could be the profile of a desensitized patient and to screen for good candidates for venom immunotherapy. [less ▲]

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See detailComparison of acute inflammatory and chronic structural asthma-like responses between C57BL/6 and BALB/c mice
Van Hove, C. L.; Maes, T.; Cataldo, Didier ULg et al

in International Archives of Allergy & Immunology (2009), 149(3), 195-207

BACKGROUND: The interactions between airway responsiveness, structural remodelling and inflammation in allergic asthma remain poorly understood. Prolonged challenge with inhaled allergen is necessary to ... [more ▼]

BACKGROUND: The interactions between airway responsiveness, structural remodelling and inflammation in allergic asthma remain poorly understood. Prolonged challenge with inhaled allergen is necessary to replicate many of the features of airway wall remodelling in mice. In both mice and humans, genetic differences can have a profound influence on allergy, inflammation, airway responsiveness and structural changes. METHODS: The aim of this study was to provide a comparative analysis of allergen-induced airway changes in sensitized BALB/c and C57BL/6 mice that were exposed to inhaled allergen for 2 ('acute'), 6 or 9 weeks ('chronic'). Inflammation, remodelling and responsiveness were analyzed. RESULTS: Both strains developed a Th-2-driven airway inflammation with allergen-specific IgE, airway eosinophilia and goblet cell hyperplasia upon 2 weeks of allergen inhalation. This was accompanied by a significant increase in airway smooth muscle mass and hyperresponsiveness in BALB/c but not in C57BL/6 mice. However, airway eosinophilia was more pronounced in the C57BL/6 strain. Chronic allergen exposure (6 or 9 weeks) resulted in an increase in airway smooth muscle mass as well as subepithelial collagen and fibronectin deposition in both strains. The emergence of these structural changes paralleled the disappearance of inflammation in both C57BL/6 and BALB/c mice and loss of hyperresponsiveness in the BALB/c strain. TGF-beta(1 )was accordingly elevated in both strains. CONCLUSION: Airway inflammation, remodelling and hyperresponsiveness are closely intertwined processes. Genetic background influences several aspects of the acute allergic phenotype. Chronic allergen exposure induces a marked airway remodelling that parallels a decreased inflammation, which was largely comparable between the two strains. [less ▲]

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See detailBiomarker discovery in asthma-related inflammation and remodeling.
Quesada Calvo, Florence ULg; Fillet, Marianne ULg; De Seny, Dominique ULg et al

in Proteomics (2009), 9(8), 2163-2170

Asthma is a complex inflammatory disease of airways. A network of reciprocal interactions between inflammatory cells, peptidic mediators, extracellular matrix components, and proteases is thought to be ... [more ▼]

Asthma is a complex inflammatory disease of airways. A network of reciprocal interactions between inflammatory cells, peptidic mediators, extracellular matrix components, and proteases is thought to be involved in the installation and maintenance of asthma-related airway inflammation and remodeling. To date, new proteic mediators displaying significant activity in the pathophysiology of asthma are still to be unveiled. The main objective of this study was to uncover potential target proteins by using surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS) on lung samples from mouse models of allergen-induced airway inflammation and remodeling. In this model, we pointed out several protein or peptide peaks that were preferentially expressed in diseased mice as compared to controls. We report the identification of different five proteins: found inflammatory zone 1 or RELM (FIZZ-1), calcyclin (S100A6), clara cell secretory protein 10 (CC10), Ubiquitin, and Histone H4. [less ▲]

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See detailNew evidence regarding the existence of segregation distortion factors associated to the genes controlling the low-gossypol seed & high-gossypol plant trait of Gossypium sturtianum
Mergeai, Guy ULg; Diouf, FBH; Benbouza, H et al

in Proceedings of the Beltwide cotton improvement conference (2009)

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See detailEvolution des caractéristiques pluviométriques dans l'est du Niger de 1940 à 2007
Ozer, Pierre ULg; Hountondji, Yvon ULg; Laminou Manzo, Ousmane

in Geo-Eco-Trop (2009), 33

Since the late 1960s, the Sahel of West Africa is affected by a dramatic drought. Based on long-term daily datasets in four synoptic stations, this article analyses recent trends in the Eastern Niger ... [more ▼]

Since the late 1960s, the Sahel of West Africa is affected by a dramatic drought. Based on long-term daily datasets in four synoptic stations, this article analyses recent trends in the Eastern Niger rainfall regime from 1940 to 2007. Results suggest that the Sahelian drought ended in the early 1990s. However, several rainfall indices still present strong significant downwards trends. We also show that the length of the rainy season has not been heavily impacted, except in its amplitude, which may suggest an increasing degree of vulnerability. [less ▲]

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See detailDroits culturels et matières culturelles
Behrendt, Christian ULg

in Verdussen, Marc (Ed.) Les droits culturels et sociaux des plus défavorisés (2009)

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See detailAnthony Giddens - Note introductive
Jacquemain, Marc ULg

Learning material (2009)

En une cinquantaine de slides schématiques, le document présente brièvement les deux grandes dimensions de la pensée de Giddens : sa théorie de la structuration, où l'action est conçue comme flux continu ... [more ▼]

En une cinquantaine de slides schématiques, le document présente brièvement les deux grandes dimensions de la pensée de Giddens : sa théorie de la structuration, où l'action est conçue comme flux continu de pratiques sociales réflexivement contrôlées ; et d'autre part, sa théorie de la modernisation avec les dimensions de réflexivité, d'auto-référentialité, de risque et de sécurité ontologique. La présentation sert à situer les apports principaux de Giddens et à préparer à une lecture en séminaire de "Modernity and self-identity". [less ▲]

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See detailOngoing desertification processes in the sahelian belt of West Africa: An evidence from the rain-use efficiency.
Hountondji, Yvon ULg; Sokpon, Nestor; Nicolas, Jacques ULg et al

in Röder, Achim; Hill, Joachim (Eds.) Recent Advances in Remote Sensing and Geoinformation Processing for Land Degradation Assessment (2009)

The implementation of the UNCCD needs the identification of areas that record declining productivity of the vegetation over long-time periods. In this scope, we analyze the state of the vegetation ... [more ▼]

The implementation of the UNCCD needs the identification of areas that record declining productivity of the vegetation over long-time periods. In this scope, we analyze the state of the vegetation productivity using 1982–1999 time series of NOAA-AVHRR NDVI data and compare it to rainfall data. For this, 354 rain gauges data distributed from yearly average isohyets 100 to 900 mm in five countries of West Africa are analyzed. We use for trends analysis, the ratio between integrated vegetation index (iNDVI) during the growing period (June to October) and the May to October sum of rainfall (RR). This ratio is a proxy of the Rain Use Efficiency is the widely accepted. Overall, 91% and 94% of RR and iNDVI data recorded positive trends over the 1982–1999 periods. Most stations in the Sahel were stable for the iNDVI/RR (49.5%). However, 37.8% showed strong to very strong negative change in the iNDVI/RR ratio, while only 1.3% showed positive trend. These strong negative trends recorded in more than 1/3 of the analyzed stations may reflect ongoing desertification processes in the Sahel and could be a starting point for the identification of hot-spots areas to determine where to take action within the National Action Programs (NAP) or Sub-Regional Action Programs (SRAP) to combat desertification. [less ▲]

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See detailIntroduction à la Théorie générale de l'Etat - Manuel (1ère édition)
Behrendt, Christian ULg; Bouhon, Frédéric ULg

Book published by Larcier. 617 pages (2009)

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See detailDirect Inclusion of Proximity-Effect Losses in Two-Dimensional Time-Domain Finite-Element Simulation of Electrical Machines
Gyselinck, Johan; Dular, Patrick ULg; Geuzaine, Christophe ULg et al

in Proceedings of the 8th International Symposium on Electric and Magnetic Fields (EMF2009) (2009)

This paper deals with eddy-current effects in the distributed winding of electrical machines, and in particular with the proximity effect and the associated losses. A previously proposed homogenization ... [more ▼]

This paper deals with eddy-current effects in the distributed winding of electrical machines, and in particular with the proximity effect and the associated losses. A previously proposed homogenization method for windings in two-dimensional (2D) time-domain finite-element (FE) models is shown to be applicable without additional computational cost, producing a precise estimate of the instantaneous proximity-effect losses. The method is illustrated by considering the conductors in a single stator slot of a 3kW induction motor. The brute-force model, with fine discretisation of each conductor, and the homogenized model yield macroscopic results that are very close to each other. [less ▲]

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See detailDes dangers de l’informatisation d’un document : le cas du FEW
Renders, Pascale ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (2009), 2

La plupart des travaux de recherche en linguistique historique du français nécessitent l’exploitation d’un outil de travail spécifique à la discipline, le Französisches Etymologisches Wörterbuch. Les ... [more ▼]

La plupart des travaux de recherche en linguistique historique du français nécessitent l’exploitation d’un outil de travail spécifique à la discipline, le Französisches Etymologisches Wörterbuch. Les structures complexes de ce dictionnaire le rendent atypique dans l’ensemble des productions lexicographiques et entraînent des pratiques particulières qui restreignent ses possibilités d’utilisation. Son informatisation devrait faciliter sa consultation et permettre de nouvelles modalités d’interrogation. Elle induit toutefois des « dangers » pour la réception du document, qui se situent à la fois dans la manière dont ce dernier est traité lors du processus et dans la façon dont le résultat sera exploité. En fin de compte, l’informatisation peut être assimilée au processus de traduction : tous deux sont à appréhender avec autant d’enthousiasme que de prudence. [less ▲]

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See detailCauses of death of harbor porpoises (Phocoena phocoena) stranded on the coasts of Belgium and Northern France
Jauniaux, Thierry ULg; Stekke, V.; Coignoul, Freddy ULg

in Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine (2009), 66(2), 392

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See detailConsensus statement on the use of gonadotropin-releasing hormone analogs in children.
Carel, Jean*-Claude; Eugster, Erica A; Rogol, Alan et al

in Pediatrics (2009), 123(4), 752-62

OBJECTIVE: Gonadotropin-releasing hormone analogs revolutionized the treatment of central precocious puberty. However, questions remain regarding their optimal use in central precocious puberty and other ... [more ▼]

OBJECTIVE: Gonadotropin-releasing hormone analogs revolutionized the treatment of central precocious puberty. However, questions remain regarding their optimal use in central precocious puberty and other conditions. The Lawson Wilkins Pediatric Endocrine Society and the European Society for Pediatric Endocrinology convened a consensus conference to review the clinical use of gonadotropin-releasing hormone analogs in children and adolescents. PARTICIPANTS: When selecting the 30 participants, consideration was given to equal representation from North America (United States and Canada) and Europe, an equal male/female ratio, and a balanced spectrum of professional seniority and expertise. EVIDENCE: Preference was given to articles written in English with long-term outcome data. The US Public Health grading system was used to grade evidence and rate the strength of conclusions. When evidence was insufficient, conclusions were based on expert opinion. CONSENSUS PROCESS: Participants were put into working groups with assigned topics and specific questions. Written materials were prepared and distributed before the conference, revised on the basis of input during the meeting, and presented to the full assembly for final review. If consensus could not be reached, conclusions were based on majority vote. All participants approved the final statement. CONCLUSIONS: The efficacy of gonadotropin-releasing hormone analogs in increasing adult height is undisputed only in early-onset (girls <6 years old) central precocious puberty. Other key areas, such as the psychosocial effects of central precocious puberty and their alteration by gonadotropin-releasing hormone analogs, need additional study. Few controlled prospective studies have been performed with gonadotropin-releasing hormone analogs in children, and many conclusions rely in part on collective expert opinion. The conference did not endorse commonly voiced concerns regarding the use of gonadotropin-releasing hormone analogs, such as promotion of weight gain or long-term diminution of bone mineral density. Use of gonadotropin-releasing hormone analogs for conditions other than central precocious puberty requires additional investigation and cannot be suggested routinely. [less ▲]

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See detailMicroarray analyses of the effects of NF-kappaB or PI3K pathway inhibitors on the LPS-induced gene expression profile in RAW264.7 cells: synergistic effects of rapamycin on LPS-induced MMP9-overexpression.
Mendes, Sofia Dos Santos; Candi, Aurelie; Vansteenbrugge, Martine et al

in Cellular Signalling (2009), 21(7), 1109-22

Lipopolysaccharide (LPS) activates a broad range of signalling pathways including mainly NF-kappaB and the MAPK cascade, but recent evidence suggests that LPS stimulation also activates the PI3K pathway ... [more ▼]

Lipopolysaccharide (LPS) activates a broad range of signalling pathways including mainly NF-kappaB and the MAPK cascade, but recent evidence suggests that LPS stimulation also activates the PI3K pathway. To unravel the specific roles of both pathways in LPS signalling and gene expression profiling, we investigated the effects of different inhibitors of NF-kappaB (BAY 11-7082), PI3K (wortmannin and LY294002) but also of mTOR (rapamycin), a kinase acting downstream of PI3K/Akt, in LPS-stimulated RAW264.7 macrophages, analyzing their effects on the LPS-induced gene expression profile using a low density DNA microarray designed to monitor the expression of pro-inflammatory genes. After statistical and hierarchical cluster analyses, we determined five clusters of genes differentially affected by the four inhibitors used. In the fifth cluster corresponding to genes upregulated by LPS and mainly affected by BAY 11-7082, the gene encoding MMP9 displayed a particular expression profile, since rapamycin drastically enhanced the LPS-induced upregulation at both the mRNA and protein levels. Rapamycin also enhanced the LPS-induced NF-kappaB transactivation as determined by a reporter assay, phosphorylation of the p38 and Erk1/2 MAPKs, and counteracted PPAR activity. These results suggest that mTOR could negatively regulate the effects of LPS on the NF-kappaB and MAPK pathways. We also performed real-time RT-PCR assays on mmp9 expression using rosiglitazone (agonist of PPARgamma), PD98059 (inhibitor of Erk 1/2) and SB203580 (inhibitor of p38(MAPK)), that were able to counteract the rapamycin mediated overexpression of mmp9 in response to LPS. Our results suggest a new pathway involving mTOR for regulating specifically mmp9 in LPS-stimulated RAW264.7 cells. [less ▲]

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See detailAsymptotic expansion of slightly coupled modal dynamic transfer functions
Denoël, Vincent ULg; Degée, Hervé ULg

in Journal of Sound & Vibration (2009), 328

In case of non-diagonal modal damping, normal modes of vibration do not decouple modal equations. The usual way to handle such a non-diagonal modal damping matrix is to neglect its off-diagonal elements ... [more ▼]

In case of non-diagonal modal damping, normal modes of vibration do not decouple modal equations. The usual way to handle such a non-diagonal modal damping matrix is to neglect its off-diagonal elements. In this paper, we propose an approximatemethod based on an asymptotic expansion of the transfer function. It is intermediate between the classical decoupling approximation and the formal solution requiring a full matrix inversion. Indeed, on the one hand, it allows to partially account for modal coupling and, on the other hand, still allows the modal equations to be solved independently from each other. We first provide the mathematical background necessary to canvass the proposed method, then consider a benchmark against which the benefits of the method are measured. [less ▲]

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See detailRisk factors for major joints heterotopic ossification after thermal injury
REMY, Christophe ULg; COLMAN, David ULg; LEDOUX, Didier ULg et al

in Burns : Journal of the International Society for Burn Injuries (2009)

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See detailDu Résume Infirmier Minimum aux Données Infirmières du Résumé Hospitalier Minimal … évolution ou révolution ?
THONON, Olivier ULg; MANNA, Mirella

in GILSON, Patrick; SUIJKERBUIJK, Hans (Eds.) Mémento de l'art infirmier 2009/2010 (2009)

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