Publications ORBi OA
Bookmark and Share    
Full Text
See detailAccretion of Gas by Globular Cluster Stars
Thoul, Anne ULg; Jehin, Emmanuel ULg; Magain, Pierre ULg et al

in Piotto, G.; Meylan, M.; Djorgovski, G. (Eds.) et al New Horizons in Globular Cluster Astronomy (2003)

Not Available

Detailed reference viewed: 14 (2 ULg)
Full Text
Peer Reviewed
See detailCompte rendu de Seuphor. N° spécial d’Archipel, Cahier international de littérature
Robert, Laurent ULg

in Textyles : Revue des Lettres Belges de Langue Française (2003), 23

Compte rendu d'un ouvrage contenant des documents du poète Michel Seuphor et apportant quelques précisions d'ordre biographique sur cet auteur

Detailed reference viewed: 30 (2 ULg)
Full Text
Peer Reviewed
See detailInteraction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression.
Twizere, Jean-Claude ULg; Kruys, Veronique; Lefebvre, Laurent et al

in Journal of the National Cancer Institute (2003), 95(24), 1846-59

BACKGROUND: The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell ... [more ▼]

BACKGROUND: The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell leukemia viruses and bovine leukemia virus). To better understand the molecular pathways leading to cell transformation, we aimed to identify cellular proteins interacting with Tax. METHODS: We used a yeast two-hybrid system to identify interacting cellular proteins. Interactions between Tax and candidate interacting cellular proteins were confirmed by glutathione S-transferase (GST) pulldown assays, co-immunoprecipitation, and confocal microscopy. Functional interactions between Tax and one interacting protein, tristetraprolin (TTP), were assessed by analyzing the expression of tumor necrosis factor-alpha (TNF-alpha), which is regulated by TTP, in mammalian cells (HeLa, D17, HEK 293, and RAW 264.7) transiently transfected with combinations of intact and mutant Tax and TTP. RESULTS: We obtained seven interacting cellular proteins, of which one, TTP, was further characterized. Tax and TTP were found to interact specifically through their respective carboxyl-terminal domains. The proteins colocalized in the cytoplasm in a region surrounding the nucleus of HeLa cells. Furthermore, coexpression of Tax was associated with nuclear accumulation of TTP. TTP is an immediate-early protein that inhibits expression of TNF-alpha at the post-transcriptional level. Expression of Tax reverted this inhibition, both in transient transfection experiments and in stably transfected macrophage cell lines. CONCLUSION: Tax, through its interactions with the TTP repressor, indirectly increases TNF-alpha expression. This observation is of importance for the cell transformation process induced by leukemogenic retroviruses, because TNF-alpha overexpression plays a central role in pathogenesis. [less ▲]

Detailed reference viewed: 45 (18 ULg)
Full Text
Peer Reviewed
See detailLa majoration des quotités insaisissables pour enfant à charge
Georges, Frédéric ULg

in Actualités du Droit (2003)

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailCalculation of the scattering coefficient of a sine-shaped surface by solving the Helmholtz integral
Embrechts, Jean-Jacques ULg; De Geetere, L.; Vermeir, G.

in Proceedings of the Institute of Acoustics (2003), 25(5), 67-74

Detailed reference viewed: 18 (3 ULg)
Full Text
Peer Reviewed
See detailCalculation of the scattering coefficient of a sine-shaped surface by using the BEM method
De Geetere, L.; Embrechts, Jean-Jacques ULg; Vermeir, G.

in Proceedings of the Institute of Acoustics (2003), 25(5), 75-83

Detailed reference viewed: 14 (4 ULg)
Full Text
Peer Reviewed
See detailRole of Cys221 and Asn116 in the zinc-binding sites of the Aeromonas hydrophila metallo-beta-lactamase.
Vanhove, Marc; Zakhem, M.; Devreese, B. et al

in Cellular and molecular life sciences : CMLS (2003), 60(11), 2501-9

The CphA metallo-beta-lactamase produced by Aeromonas hydrophila exhibits two zinc-binding sites. Maximum activity is obtained upon binding of one zinc ion, whereas binding of the second zinc ion results ... [more ▼]

The CphA metallo-beta-lactamase produced by Aeromonas hydrophila exhibits two zinc-binding sites. Maximum activity is obtained upon binding of one zinc ion, whereas binding of the second zinc ion results in a drastic decrease in the hydrolytic activity. In this study, we analyzed the role of Asn116 and Cys221, two residues of the active site. These residues were replaced by site-directed mutagenesis and the different mutants were characterized. The C221S and C221A mutants were seriously impaired in their ability to bind the first, catalytic zinc ion and were nearly completely inactive, indicating a major role for Cys221 in the binding of the catalytic metal ion. By contrast, the binding of the second zinc ion was only slightly affected, at least for the C221S mutant. Mutation of Asn116 did not lead to a drastic decrease in the hydrolytic activity, indicating that this residue does not play a key role in the catalytic mechanism. However, the substitution of Asn116 by a Cys or His residue resulted in an approximately fivefold increase in the affinity for the second, inhibitory zinc ion. Together, these data suggested that the first zinc ion is located in the binding site involving the Cys221 and that the second zinc ion binds in the binding site involving Asn116 and, presumably, His118 and His196. [less ▲]

Detailed reference viewed: 16 (0 ULg)
Full Text
See detailAnalyse sensorielle : principes de base.
Blecker, Christophe ULg

in Cours d'analyse sensorielle du beurre et du lait en poudre. (2003)

Detailed reference viewed: 43 (5 ULg)
Full Text
See detailVers une politique de qualité, à quel prix ?
Claustriaux, Jean-Jacques ULg; Cordier, L.; Duquesne, Brigitte ULg et al

Scientific conference (2003)

Description de l'utilisation d'une base de données relative aux achats de produits alimentaires effectués par des ménages.

Detailed reference viewed: 17 (5 ULg)
Full Text
Peer Reviewed
See detailRétention gazeuse dans une colonne à bulles contenant un liquide visqueux non-newtonien
Fransolet, Emmanuelle; Coumont, V.; Crine, Michel ULg et al

in Tribune de l'Eau (La) (2003), 56(622), 15-20

Detailed reference viewed: 28 (2 ULg)
Full Text
See detailLe positionnement multidimensionnel : principes et applications
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (2003), (1), 1-32

This note describes some multidimensional scaling methods for two-way, one-mode tables and for three-way, two-mode tables. The methods are illustrated by an example processed by PROC MDS of SAS software.

Detailed reference viewed: 58 (0 ULg)
Full Text
Peer Reviewed
See detailComparaison empirique des estimateurs des taux d'erreur en analyse discriminante
Glele Kakai, R.; Piraux, F.; Fonton, N. H. et al

in Revue de Statistique Appliquée (2003), LI(3), 61-74

Monte Carlo experiments are performed to compare twenty estimators or error rates in discriminant analysis in the case of two populations and linear classification rule. Several distributions (normal, chi ... [more ▼]

Monte Carlo experiments are performed to compare twenty estimators or error rates in discriminant analysis in the case of two populations and linear classification rule. Several distributions (normal, chi-square and beta) have been considered. Estimators eOS (for actual and expected error rate) and eB (for optimal error rate) are the best, except for distributions very different from normal distributions. The e632 estimator is the best non parametric estimator. This estimator is better than parmetric estimators for distributions very different from normal distributions. [less ▲]

Detailed reference viewed: 18 (0 ULg)
Full Text
See detailInterprétation géométrique de la régression
Iemma, A. F.; Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (2003), (2), 1-28

Detailed reference viewed: 9 (0 ULg)
Full Text
See detailElevated atmospheric CO2 influences ammonia oxidiser community structure and net nitrification
Carnol, Monique ULg; Malchair, Sandrine ULg

in International Symposium: Structure and Function of Soil Microbiota, Philipps-University Marburg, Germany, September 18-20, 2003 (2003)

Detailed reference viewed: 7 (2 ULg)
Full Text
Peer Reviewed
See detailIdentités et valeurs politiques : quelle homogénéité pour l'Eurégio ?
Jacquemain, Marc ULg

in Fédéralisme - Régionalisme (2003)

Euregio Mosa-Rhine is a euregional structure that agregates Province of Liege and German-speaking belgian community (Belgium) Province of Limburg (Belgium), Province of South-Limburg (Netherlands) and ... [more ▼]

Euregio Mosa-Rhine is a euregional structure that agregates Province of Liege and German-speaking belgian community (Belgium) Province of Limburg (Belgium), Province of South-Limburg (Netherlands) and Regio Aachen (Germany). It is supposed to be an area with many commercial and cultural inter-relations. Throuth a survey led in 2002, the paper tries to assess cultural similitaries and differences between the five components at the level of social identity and political values. It shows a contrasted landscape where the two dutch-speaking parts being more individualist, the german part being more comunitarian and, at the heart, the province of Liege more materialist and egalitarian. [less ▲]

Detailed reference viewed: 23 (5 ULg)
Full Text
Peer Reviewed
See detailOptimizing treatment with thioguanine derivatives in inflammatory bowel disease.
Louis, Edouard ULg; Belaiche, Jacques ULg

in Bailliere's Best Practice & Research. Clinical Gastroenterology (2003), 17(1), 37-46

Thioguanine derivatives, azathioprine and 6-mercaptopurine, represent major drugs in the treatment of chronic active inflammatory bowel disease. They are effective in two-thirds of the patients and safe ... [more ▼]

Thioguanine derivatives, azathioprine and 6-mercaptopurine, represent major drugs in the treatment of chronic active inflammatory bowel disease. They are effective in two-thirds of the patients and safe over the long term in patients who can tolerate them (80-90%). Recent progress in understanding the metabolism of these drugs and its implication in clinical practice have brought up new tools and strategies that are proposed to optimize treatment. In particular, the measurement and characterization of key enzymes and metabolites may have clinical impact. Thus, thiopurine methyl transferase genotyping and activity measurement, as well as erythrocytes, 6-thioguanine nucleotides and 6-methyl mercaptopurine levels, may help in some situations of intolerance or inefficacy with these drugs. Indications for starting and stopping treatment with thioguanine derivatives are also discussed. [less ▲]

Detailed reference viewed: 21 (2 ULg)