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See detailRecombinant human erythropoietin therapy after allogeneic hematopoietic cell transplantation with a nonmyeloablative conditioning regimen: low donor chimerism predicts for poor response.
Vanstraelen, Gaëtan; Baron, Frédéric ULg; Willems, Evelyne ULg et al

in Experimental hematology (2006), 34(7), 841-50

PURPOSE: After allogeneic hematopoietic stem cell transplantation with nonmyeloablative conditioning (NMHCT), many patients experience prolonged anemia and require red blood cell (RBC) transfusions. We ... [more ▼]

PURPOSE: After allogeneic hematopoietic stem cell transplantation with nonmyeloablative conditioning (NMHCT), many patients experience prolonged anemia and require red blood cell (RBC) transfusions. We enrolled 60 consecutive patients undergoing NMHCT in a phase II trial to determine the optimal utilization of recombinant human erythropoietin (rHuEPO) therapy in this setting. PATIENTS AND METHODS: The first 14 NMHCT recipients did not receive rHuEPO (control group). Nineteen patients were scheduled to start rHuEPO on day 0 (EPO group 2) and 27 patients on day 28 after the transplant (EPO group 1). RHuEPO was administered subcutaneously once weekly at a dose of 500 U/kg/wk with the aim of achieving hemoglobin (Hb) levels of 13 g/dL. The 3 groups were well balanced for major characteristics. RESULTS: During the first month (p < 0.0001) as well as days 30 to 100 (p < 0.0001) and days 100 to 180 (p < 0.0001), Hb values were higher in patients receiving rHuEPO compared to those not receiving it. However, transfusion requirements were significantly decreased only in the first month in EPO group 2 (p = 0.0169). T-cell chimerism above 60% on day 42 was the best predictor of Hb response (p < 0.0001) or Hb correction (p = 0.0217), but myeloid chimerism above 90% also predicted for Hb response (p = 0.0069). Hb response was also decreased in patients receiving CD8-depleted grafts and increased in the few patients not receiving TBI, but only in univariate analysis. CONCLUSIONS: Anemia after NMHCT is sensitive to rHuEPO therapy, but less so than after conventional allogeneic HCT. RHuEPO decreases transfusion requirements only in the first 30 days posttransplant. T-cell chimerism below 60% on day 42 impaired Hb response, suggesting possible inhibition of donor erythropoiesis by residual recipient lymphocytes. A prospective randomized trial should be performed with rHuEPO starting on the day of transplantation to assess its clinical benefit in terms of transfusion requirements and quality of life. [less ▲]

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See detailSur les difficultés d'application du standstill dans la passation des marchés publics
Lewalle, Paul ULg; Donnay, Luc ULg

in Revue de la Faculté de Droit de l'Université de Liège (2006), 1-2

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See detailBoules et autres masses". Prise en charge rationnelle des tumeurs des tissus mous."
Kurth, William ULg; Gillet, Philippe ULg

in Revue Médicale de Liège (2006), 61(11), 763-70

Patients with soft-tissue tumours usually consult for a mass at the level of an extremity or the torso. This article aims to help the general practitioner and the general surgeon in the standardized setup ... [more ▼]

Patients with soft-tissue tumours usually consult for a mass at the level of an extremity or the torso. This article aims to help the general practitioner and the general surgeon in the standardized setup of these tumours. The epidemiology, clinical presentation and evaluation as well as the useful exams to be performed, including biopsy, are developped, in order to obtain rational principles for the diagnostic setup and surgical decision-making. [less ▲]

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See detailEtude clinique du mois. L'etude DREAM: prevention du diabete de type 2 par le ramipiril et/ou la rosiglitazone chez les personnes dysglycemiques sans maladie cardio-vasculaire.
Scheen, André ULg

in Revue Médicale de Liège (2006), 61(10), 728-32

DREAM ("Diabetes Reduction Assessment with ramipril and rosiglitazone Medication") is a double-blind randomised placebo-controlled clinical trial with a 2-by-2 factorial design aiming to study the effects ... [more ▼]

DREAM ("Diabetes Reduction Assessment with ramipril and rosiglitazone Medication") is a double-blind randomised placebo-controlled clinical trial with a 2-by-2 factorial design aiming to study the effects of an ACE inhibitor (ramipril 15 mg/day) and/or a thiazolidinedione (rosiglitazone 8 mg/day) on the development of diabetes or death (primary outcome) and on the regression to normoglycaemia (secondary outcome) in 5269 adults aged 30 years or more with impaired fasting glucose and/or impaired glucose tolerance, and no previous cardiovascular disease. There was no statistical evidence of an interaction between the ramipril and the rosiglitazone arms. After a mean follow up of 3 years, the use of ramipril does not significantly reduce the incidence of diabetes or death but does significantly increase regression to normoglycaemia. In contrast, the treatment with rosiglitazone reduces by almost 60% the incidence of type 2 diabetes and increases the likelihood (+70%) of regression to normoglycaemia. Whether it is a true prevention effect or simply a treatment effect remains to be determined when participants will be retested after a washout period. Cardiovascular event rates were rather low and much the same in all treatment groups, except a higher rate of heart failure in the rosiglitazone group. These results suggest that the routine inhibition of the renin-angiotensin system for the express purpose of preventing diabetes is not indicated in individuals not at high risk for cardiovascular disease and appear to confirm the promises of the glitazone use in the very early stage of the natural history of type 2 diabetes. [less ▲]

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See detailLe syndrome metabolique: physiopathologie et traitement
Scheen, André ULg

in Athérosclérose, athérothrombose (2006)

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See detailNote on singular optima in laminate design problems
Bruyneel, Michael; Duysinx, Pierre ULg

in Structural and Multidisciplinary Optimization (2006), 31(2), 156-159

This paper studies the design of laminates subject to restrictions on the ply strength. The minimum weight design is considered. It is shown that this formulation includes singular optima, which are ... [more ▼]

This paper studies the design of laminates subject to restrictions on the ply strength. The minimum weight design is considered. It is shown that this formulation includes singular optima, which are similar to the ones observed in topology optimization including local stress constraints. In laminate design, these singular optima are linked to the removal of 'zero thickness' plies from the stacking sequence. It is shown how the fiber orientation variables can circumvent the singularity by relaxing the strength constraints related to such vanishing plies. This demonstrates the key role of fiber orientations in the optimization of laminates and the need for their efficient treatment as design variables. [less ▲]

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See detailLe Conseil d'Etat et la connexité
Donnay, Luc ULg

in Journal des Tribunaux (2006), 6234

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See detailRisico's verbonden aan Enterobacter sakazakii in zuigelingenvoeding.
Uyttendaele, M.; Herman, L.; Daube, Georges ULg et al

in Tijdschrift voor Geneeskunde (2006), 62

Enterobacter sakazakii is een zeldzame maar bekende oorzaak van neonatale sepsis en een ernstig verlopende vorm van meningitis met een mortaliteit van 10 tot 80 %. Verschillende infecties zijn in verband ... [more ▼]

Enterobacter sakazakii is een zeldzame maar bekende oorzaak van neonatale sepsis en een ernstig verlopende vorm van meningitis met een mortaliteit van 10 tot 80 %. Verschillende infecties zijn in verband gebracht met de consumptie van zuigelingenvoeding. In opdracht van het FAVV (Federaal Agentschap voor de Veiligheid van de Voedselketen) werd een studie verricht met betrekking tot het contaminatieniveau, de voorwaarden voor groei en overleving en de risico’s op infectie van E. sakazakii in zuigelingenvoeding. Dit met het oog op het formuleren van richtlijnen omtrent de voorwaarden voor bereiding, bewaring en toediening van zuigelingenvoeding . Melkpoeder is niet absoluut steriel is en een mogelijks lage besmetting (productienorm: < 1 kve per 10g) met E. sakazakii kan aanwezig zijn. Bij bereiding moeten de nodige hygiënische maatregelen in acht worden genomen. Er wordt aanbevolen de bereide zuigelingenvoeding binnen maximaal 2h te koelen tot 5°C en een maximum bewaartijd van 24h te respecteren. Opwarmen van het gerehydrateerd melkpoeder tot 37°C, warm houden en toedienen van bereide zuigelingenvoeding is een totaalproces dat maximum 1h in beslag mag nemen opdat er zich een voldoende marge tussen het aantal E. sakazakii cellen en de infectieve dosis zou bevinden. Door opvolgen van deze richtlijnen kan het risico op neonatale E. sakazakiiinfecties sterk gereduceerd worden. [less ▲]

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See detailInhibiteurs de l'enzyme de conversion de l'angiotensine ou antagonistes des récepteurs de l'angiotensine 2 en pathologie cardio-vasculaire et néphrologique : que nous dit l'Evidence Based Medicine?
Krzesinski, Jean-Marie ULg; Montrieux, Christian ULg; Scheen, André ULg

in Revue Médicale de Liège (2006), 61(5-6), 414-422

Inhibitors of the renin-angiotensin system have proved their great value in secondary prevention trials for cardiovascular or renal complications. In favour of the preferred use of angiotensin receptor ... [more ▼]

Inhibitors of the renin-angiotensin system have proved their great value in secondary prevention trials for cardiovascular or renal complications. In favour of the preferred use of angiotensin receptor antagonists stand their excellent tolerance and the possible therapeutic escape seen with angiotensin converting enzyme inhibitors. For the preferential use of the latter, the arguments are the absence of a real proof of any superiority of the angiotensin receptor blockers and their higher cost. The wisdom is to initially use angiotensin converting enzyme inhibitors in secondary prevention excepted when they are not well tolerated. The large ONTARGET cardiovascular prevention trial should help solve this controversy. [less ▲]

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See detailRevue de la Faculté de droit de l'Université de Liège : Tables décennales 1996-2005
Bruyère, Aurélie ULg; Thys, Laurence ULg

in Revue de la Faculté de droit de l'Université de Liège (2006)

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See detailInterférences entre phonologie et syntaxe en pathologie développementale du langage
Parisse, Christophe; Maillart, Christelle ULg

in Langage et l'Homme (Le) : Recherches Pluridisciplinaires sur le Langage (2006), 41

We compare three theories (pure phonological theory, surface theory, and mapping theory) about language developmental disorders considering that phonological difficulties are the main reason for the ... [more ▼]

We compare three theories (pure phonological theory, surface theory, and mapping theory) about language developmental disorders considering that phonological difficulties are the main reason for the children’s disorders. First, we identified the linguistic parameters (salience, phonological complexity, syntactic complexity, lexical/functional, semantic/syntactic) that are fundamental to these theories. Then we tested the validity of these parameters by testing them against results obtained by SLI children and control children. Nine syntactic categories were tested (determiner, noun, verb, etc.) No theory could fully explain the results obtained. Some linguistic parameters (eg. phonological complexity) are very interesting but fail to explain all results. Some other parameters (eg. salience) turned out to be inadequate to explain the results of French-speaking children. [less ▲]

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See detailThe left intraparietal sulcus and verbal short-term memory: Focus of attention or serial order ?
Majerus, Steve ULg; Poncelet, Martine ULg; Van der Linden, Martial ULg et al

in Neuroimage (2006), 32(2), 880-891

One of the most consistently activated regions during verbal short-term memory (STM) tasks is the left intraparietal sulcus (IPS). However, its precise role remains a matter of debate. While some authors ... [more ▼]

One of the most consistently activated regions during verbal short-term memory (STM) tasks is the left intraparietal sulcus (IPS). However, its precise role remains a matter of debate. While some authors consider the IPS to be a specific store for serial order information, other data suggest that it serves a more general function of attentional focalization. In the current fMRI experiment, we investigated these two hypotheses by presenting different verbal STM conditions that probed recognition for word identity or word order and by assessing functional connectivity of the left IPS with distant brain areas. If the IPS has a role of attentional focalization, then it should be involved in both order and item conditions, but it should be connected to different brain regions, depending on the neural substrates involved in processing the different types of information (order versus phonological/orthographic) to be remembered in the item and order STM conditions. We observed that the left IPS was activated in both order and item STM conditions but for different reasons: during order STM, the left IPS was functionally connected to serial/temporal order processing areas in the right IPS, premotor and cerebellar cortices, while during item STM, the left IPS was connected to phonological and orthographic processing areas in the superior temporal and fusiform gyri. Our data support a position considering that the left IPS acts as an attentional modulator of distant neural networks which themselves are specialized in processing order or language representations. More generally, they strengthen attention-based accounts of verbal STM. [less ▲]

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See detailLe bilan articulatoire et phonologique
Maillart, Christelle ULg

in Pierart, Bernadette; Estienne, Françoise (Eds.) L’évaluation du langage et de la voix. (2006)

Ce chapitre s’intéresse à l’évaluation des composants phonologiques du langage de l’enfant. Dans la première partie du chapitre, les caractéristiques phonétiques et phonologiques de la langue française ... [more ▼]

Ce chapitre s’intéresse à l’évaluation des composants phonologiques du langage de l’enfant. Dans la première partie du chapitre, les caractéristiques phonétiques et phonologiques de la langue française seront détaillées. Les fondements théoriques de l’évaluation phonologiques seront ensuite rapidement abordés avant de présenter plus longuement la double démarche, tant cognitive que linguistique, utilisée pour effectuer le diagnostic des troubles articulatoires et phonologiques. Nous reviendrons par la suite sur des éléments de diagnostic différentiel pour distinguer ces deux types de troubles puis nous terminerons en abordant les perspectives laissées ouvertes dans ce domaine. [less ▲]

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See detailComment je traite...des cors et des callosités.
Hermanns-Lê, Trinh ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(7-8), 545-7

Corns and callosities are the expression of a peculiar aspect of mecanobiology of the foot. They are more frequent with ageing, particularly in women. These lesions represent a risk factor for the ... [more ▼]

Corns and callosities are the expression of a peculiar aspect of mecanobiology of the foot. They are more frequent with ageing, particularly in women. These lesions represent a risk factor for the diabetic foot. Prevention measures are important to follow in predisposed individuals. Several medicinal and non medicinal treatments have proven their efficacy. [less ▲]

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See detailLe pimecrolimus (Elidel) hors des sentiers battus.
Hermanns-Lê, Trinh ULg; Hermanns, Jean-François ULg; Thirion, Laurence et al

in Revue Médicale de Liège (2006), 61(4), 256-9

Pimecrolimus is an immune downregulator that belongs to the class of calcineurin inhibitors. Its efficacy is recognized for the topical treatment of the mild to moderate types of atopic dermatitis. In ... [more ▼]

Pimecrolimus is an immune downregulator that belongs to the class of calcineurin inhibitors. Its efficacy is recognized for the topical treatment of the mild to moderate types of atopic dermatitis. In addition, the drug shows activity in a series of other dermatitides. We report a review of the international literature about this topic. [less ▲]

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See detailComment j'explore... une perte de cheveux chez un patient cancéreux. Le trichogramme.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue de l’Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (2006), 33

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See detailLe 17-butyrate d'hydrocortisone (Locoid), un trentenaire toujours innovateur.
Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(2), 128-30

Since half a century, dermocorticoids represent worthy compounds in dermatological therapy. About thirty years ago, hydrocortisone 17-butyrate was introduced on the Belgian market. This compound combines ... [more ▼]

Since half a century, dermocorticoids represent worthy compounds in dermatological therapy. About thirty years ago, hydrocortisone 17-butyrate was introduced on the Belgian market. This compound combines good efficiency and reduced risk of side effects. Its topical formulations have been enriched over time. The original Locoid lipocream and Locoid Crelo presentations confer remarkable qualities to the product. We report a synopsis of clinical and translational studies devoted to this unique dermocorticoid. [less ▲]

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See detailComment je traite ... un psoriasis en plaques par l'association calcipotriol-dipropionate de betamethasone.
Henry, Frédérique ULg; Flagothier, Caroline ULg; Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2006), 61(3), 139-41

The combination of calcipotriol and betamethasone dipropionate in a single topical formulation is a recent advance in treatment of plaque type psoriasis. Studies rooted on evidence-based medicine have ... [more ▼]

The combination of calcipotriol and betamethasone dipropionate in a single topical formulation is a recent advance in treatment of plaque type psoriasis. Studies rooted on evidence-based medicine have been recently published. We report a synthesis and a critical analysis, critical analysis of these investigations, and translate their data with a view to apply them in daily practice. [less ▲]

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