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See detailDecreased local control following radiation therapy alone in early larynx cancer with anterior commisure extension
Ozsahin; Bron; COUCKE, Philippe ULg et al

in Radiotherapy & Oncology (2002), 64(supp 1), 243-244

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See detailDiscrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET
Herholz, K.; Salmon, Eric ULg; Perani, D. et al

in Neuroimage (2002), 17(1), 302-316

A new diagnostic indicator of FDG PET scan abnormality, based on age-adjusted t statistics and an automated voxel-based procedure, is presented and validated in a large data set comprising 110 normal ... [more ▼]

A new diagnostic indicator of FDG PET scan abnormality, based on age-adjusted t statistics and an automated voxel-based procedure, is presented and validated in a large data set comprising 110 normal controls and 395 patients with probable Alzheimer's disease (AD) that were studied in eight participating centers. The effect of differences in spatial resolution of PET scanners was minimized effectively by filtering and masking. In controls FDG uptake declined significantly with age in anterior cingulate and frontolateral perisylvian cortex. In patients with probable AD decline of FDG uptake in posterior cingulate, temporoparietal, and prefrontal association cortex was related to dementia severity. These effects were clearly distinct from age effects in controls, suggesting that the disease process of AD is not related to normal aging. Women with probable AD had significantly more frontal metabolic impairment than men. The new indicator of metabolic abnormality in AD-related regions provided 93% sensitivity and specificity for distinction of mild to moderate probable AD from normals, and 84% sensitivity at 93% specificity for detection of very mild probable AD (defined by Mini Mental Score 24 or better). All regions related to AD severity were already affected in very mild AD, suggesting that all vulnerable areas are affected to a similar degree already at disease onset. Ventromedial frontal cortex was also abnormal. In conclusion, automated analysis of multicenter FDG PET is feasible, provides insights into AD pathophysiology, and can be used potentially as a sensitive biomarker for early AD diagnosis. (C) 2002 Elsevier Science (USA). [less ▲]

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See detailDécompensation cardiaque, fonction rénale et anti-inflammatoires non stéroïdiens
Krzesinski, Jean-Marie ULg; Piront, Patricia ULg

in Revue Médicale de Liège (2002), 57(9), 582-586

Thanks to a case report of heart failure in an old people with a cardiovascular history treated by the new coxib-inhibitors, we would like to remember and insist to the risk of renal and cardiac ... [more ▼]

Thanks to a case report of heart failure in an old people with a cardiovascular history treated by the new coxib-inhibitors, we would like to remember and insist to the risk of renal and cardiac complications which appear to be the same as those with the non specific antiinflammatory drugs. Old age, diuretic or converting enzyme inhibitor treatment, heart failure, liver insufficiency, nephrotic syndrome are risk factors for acute renal failure and cardiac failure during such treatment. [less ▲]

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See detailPharma clinics le medicament du mois. L'esomeprazole
Louis, Edouard ULg

in Revue Médicale de Liège (2002), 57(9), 610-2

Esomeprazole is the last PPI registered on the Belgian market. It is the stable s-isomer of omeprazole. It has a better pharmacokinetic profile than omeprazole (racemate), allowing also better clinical ... [more ▼]

Esomeprazole is the last PPI registered on the Belgian market. It is the stable s-isomer of omeprazole. It has a better pharmacokinetic profile than omeprazole (racemate), allowing also better clinical performances. Esomeprazole is the first PPI shown superior to omeprazole in acute and chronic treatment of gastro-esophageal reflux disease. Controlled trials with this drug have also allowed to define new cost-effective strategies, such as on demand treatment for endoscopy-negative gastro-esophageal reflux and one week treatment of Helicobacter pylori positive duodenal ulcer. [less ▲]

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See detailUsefulness of F-18-FDG PET in the post-therapy surveillance of endometrial carcinoma
Belhocine, Tarik; De Barsy, Caroline; Hustinx, Roland ULg et al

in European Journal of Nuclear Medicine and Molecular Imaging (2002), 29(9), 1132-1139

The aim of this study was to assess the usefulness of fluorine-18 tluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) in the post-therapy surveillance of endometrial carcinomas. Forty-one ... [more ▼]

The aim of this study was to assess the usefulness of fluorine-18 tluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) in the post-therapy surveillance of endometrial carcinomas. Forty-one fully corrected whole-body PET studies were performed in 34 women with previously treated endometrial cancers as a part of their follow-up programme. In 28 studies, FDG PET was indicated to localise a recurrence suspected at the control visits on the basis of clinical examination and/or radiological abnormalities (chest X-ray, CT or MRI) and/or elevated tumour marker levels (CA125, CEA). Another 13 studies were performed as a simple surveillance procedure. Overall, in 26 studies PET detected recurrent disease, which was confirmed either by histology (n=7) or by clinical and radiological outcomes (n=19). In 88% of the cases, the PET findings confirmed recurrence suggested by routine follow-up. In the remaining 12% of cases, PET detected asymptomatic recurrences that were unsuspected at the control visits. Whole-body PET accurately localised the site of confirmed recurrences as being above and below the diaphragm in 50%, only below the diaphragm in 35% and only above the diaphragm in 15%. In one patient, however, PET missed microscopic lung metastases shown on thoracic CT, and in three studies, metabolic imaging results were not confirmed. In I I of 12 negative PET studies, no subsequent clinical or radiological recurrences were observed with a median follow-up of 10 months. Overall, the results of PET agreed well with the final diagnosis (Cohen's kappa coefficient =0.78). In 9/26 patients (35%) with confirmed recurrences, the PET findings significantly altered the treatment choice by detecting either clinically or radiologically unsuspected distant metastases. The sensitivity, specificity, diagnostic accuracy and positive and negative predictive values of FDG PET imaging in the post-therapy surveillance of endometrial carcinomas were 96%, 78%, 90%, 89% and 91 %, respectively. Indeed, the high likelihood ratio for a positive test result (4.5) and the low likelihood ratio for a negative test result (0.05) demonstrated the clinical utility of metabolic imaging in "ruling in" disease as well as "ruling out" recurrence. In conclusion, whole-body FDG PET appears useful in the post-therapy surveillance of endometrial cancers, both for the accurate localisation of suspected recurrences and for the detection of asymptomatic recurrent disease. [less ▲]

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See detailProgress in microscopic modeling of damage in steel at high temperature
Remy, M.; Castagne, Sylvie; Habraken, Anne ULg

in International Journal of Forming Processes (2002), 5(N°2-3-4/2002), 445-455

With the goal to study crack propagation in continuous casting, this paper presents an on going project to develop and identify a mathematical finite element model of damage in steel at high temperature ... [more ▼]

With the goal to study crack propagation in continuous casting, this paper presents an on going project to develop and identify a mathematical finite element model of damage in steel at high temperature. A representative microscopic cell of the material is presented and adapted to available chemical information, precipitation state and micro-structures observed using metallographic as weel as imaging methods (optical microscopy, SEM, orientation imaging microscopy). Compression tests of cylindrical samples after a thermal treatment have been performed to identify the parameters of an elasto-visco-plastique law of Norton-Hoff type. Hot damage tests in tensile and compression states help to provide information on crack appearance. [less ▲]

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See detailMicro-macro analysis of steel sheet behaviour in finite element simulations. Application to deep-drawing process.
Duchene, Laurent ULg; Godinas, A.; Cescotto, Serge ULg et al

in Cescotto, Serge (Ed.) Proceedings of the Sixth European Mechanics of Materials Conference (EMMC6) Non Linear Mechanics of Anisotropic Materials (2002, September)

This paper presents a constitutive law based on Taylor’s model implemented in our non-linear finite element code LAGAMINE. The yield locus is only locally described and a particular interpolation method ... [more ▼]

This paper presents a constitutive law based on Taylor’s model implemented in our non-linear finite element code LAGAMINE. The yield locus is only locally described and a particular interpolation method has been developed. This local yield locus model uses a discrete representation of the material’s texture. The interpolation method is presented and a deep-drawing application is simulated in order to show up the influence of the texture evolution during forming processes. [less ▲]

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See detailProposition d'une méthode d'inventaire des dégâts frais de cervidés applicable en Région wallonne : les dégâts d'écorcement
Lejeune, Philippe ULg; Rotheudt, H.; Verrue, V.

in Forêt Wallonne (2002), (60), 4-10

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See detailComputation of simultaneous available transfer capability under thermal and voltage security constraints
Capitanescu, Florin ULg; Van Cutsem, Thierry ULg

(2002, September)

This paper proposes a method to compute the Available Transfer Capability (ATC) of a power system under both thermal and voltage security constraints. The objective is to determine, in some optimal manner ... [more ▼]

This paper proposes a method to compute the Available Transfer Capability (ATC) of a power system under both thermal and voltage security constraints. The objective is to determine, in some optimal manner, the ATC of several simultaneous transactions, such that any postulated contingency does not cause voltage instability nor thermal overloads. Thermal constraints are derived for every branch likely to be overloaded in post-contingency states. Voltage security constraints are derived from voltage unstable post-contingency scenario, obtained by Quasi Steady- State simulation, a fast time-domain method. The paper also addresses the discrimination problem, i.e. the fact that the computed ATC might favor some trades to the detriment of others. Variants will be discussed to deal with such situations. The method is illustrated on an 80-bus test system. [less ▲]

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See detailLe cinéma d’animation et ses thanatomorphoses (fragments sur le monstre, la charogne, le montage et l’animation)
Tomasovic, Dick ULg

in Cinémas : revue d'études cinématographiques / Cinémas: Journal of Film Studies (2002), 13(Automne), 143-164

The role and limits of editing in animation film are reconsidered here. It is no longer a matter of perceiving this practice as “simply” assembling shots, associating random elements, linking diverse ... [more ▼]

The role and limits of editing in animation film are reconsidered here. It is no longer a matter of perceiving this practice as “simply” assembling shots, associating random elements, linking diverse pieces and creating a monstrous body, but rather, it is presently regarded as a continual process of managing transitions, shifting between images, transforming inanimate objects, transmuting immobile elements and transfiguring inert beings. Thus, the animation film’s purpose is less phantasmal, to be a giver of life, as it is phantasmagoric, to be an animator of death. [less ▲]

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See detailDemographic and clinical parameters influencing the short-term outcome of anti-tumor necrosis factor (infliximab) treatment in Crohn's disease
Vermeire, S.; Louis, Edouard ULg; Carbonez, A. et al

in American Journal of Gastroenterology (2002), 97(9), 2357-2363

OBJECTIVE: Infliximab is an effective treatment for refractory or fistulizing Crohn's disease (CD). However, about 30% of patients do not respond to infliximab for unknown reasons. Identifying predictive ... [more ▼]

OBJECTIVE: Infliximab is an effective treatment for refractory or fistulizing Crohn's disease (CD). However, about 30% of patients do not respond to infliximab for unknown reasons. Identifying predictive factors of response is important for optimizing clinical management and for better understanding infliximab's mechanisms of action. The aim of this study was to assess whether demographic or clinical parameters influence short-term response to infliximab. METHODS: The first 240 CD patients of the Belgian Infliximab Expanded Access Program were studied for response to infliximab treatment and assessed at 4 (refractory luminal CD) or 10 wk (fistulizing CD) after the first infusion. Detailed demographic and clinical information on age, sex, type of disease (fistulizing or refractory), Crohn's Disease Activity Index score, C-reactive protein (CRP), smoking habits, disease duration, localization of disease, concomitant medication, and previous surgery were obtained from all patients. Logistic regression and decision tree analysis were performed. RESULTS: There were 73.5% responders and 26.5% nonresponders to treatment. Stepwise logistic regression identified age (OR = 0.971, 95% CI = 0.947-0.995, p = 0.018), isolated ileitis (OR = 0.359, 95% CI 0.177-0.728, p = 0.004), and previous surgery (OR 0.429, 95% CI = 0.233-0.787, p = 0.006) as inversely correlated with response, whereas isolated colitis (OR = 1.905, 95% CI = 1.010-3.597, p = 0.046) and concomitant immunosuppressive treatment (OR = 2.670, 95% CI = 1.430-5.016, p = 0.0022) were positively correlated with response to infliximab. Surprisingly, smoking habits were not retained as predictors for response. Decision tree analysis provided a working algorithm based on age and immunosuppressive treatment that warrants further exploration. CONCLUSIONS: In this large cohort of infliximab-treated CD patients, young age, Crohn's colitis, and concomitant immunosuppressive treatment were identified as independent variables favoring short-term response to infliximab. [less ▲]

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See detailLes paysages
Melin, Eric ULg; Feltz, Claude ULg; Droeven, Emilie ULg et al

Report (2002)

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See detailLe patrimoine naturel
Feltz, Claude ULg; Guillitte, Olivier ULg; Van Der Kaa, Claire ULg et al

Report (2002)

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See detailComparaison de différents types de compostages de matières organiques diverses non valorisées par les paysans au Rwanda
Culot, Marc ULg; Mbonigaba Muhinda, Jean-Jacques; Maniraguha, J. D.

in Etudes Rwandaises : Série sciences exactes, naturelles et appliquées (2002), 5

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See detailEffets de divers types de matières organiques en comparaison avec une fertilisation minérale sur les propriétés et la production d'un sol acide au Rwanda
Culot, Marc ULg; Mbonigaba Muhinda, Jean-Jacques; Bizimara, R.

in Etudes Rwandaises (2002), 5

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See detailSystematic regularization of linear inverse solutions of the EEG source localization problem
Phillips, Christophe ULg; Rugg, Michael D; Friston, Karl J

in NeuroImage (2002), 17(1), 287-301

Distributed linear solutions of the EEG source localization problem are used routinely. Here we describe an approach based on the weighted minimum norm method that imposes constraints using anatomical and ... [more ▼]

Distributed linear solutions of the EEG source localization problem are used routinely. Here we describe an approach based on the weighted minimum norm method that imposes constraints using anatomical and physiological information derived from other imaging modalities to regularize the solution. In this approach the hyperparameters controlling the degree of regularization are estimated using restricted maximum likelihood (ReML). EEG data are always contaminated by noise, e.g., exogenous noise and background brain activity. The conditional expectation of the source distribution, given the data, is attained by carefully balancing the minimization of the residuals induced by noise and the improbability of the estimates as determined by their priors. This balance is specified by hyperparameters that control the relative importance of fitting and conforming to prior constraints. Here we introduce a systematic approach to this regularization problem, in the context of a linear observation model we have described previously. In this model, basis functions are extracted to reduce the solution space a priori in the spatial and temporal domains. The basis sets are motivated by knowledge of the evoked EEG response and information theory. In this paper we focus on an iterative "expectation-maximization" procedure to jointly estimate the conditional expectation of the source distribution and the ReML hyperparameters on which this solution rests. We used simulated data mixed with real EEG noise to explore the behavior of the approach with various source locations, priors, and noise levels. The results enabled us to conclude: M Solutions in the space of informed basis functions have a high face and construct validity, in relation to conventional analyses. (ii) The hyperparameters controlling the degree of regularization vary largely with source geometry and noise. The second conclusion speaks to the usefulness of using adaptative ReML hyperparameter estimates. (C) 2002 Elsevier Science (USA). [less ▲]

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See detailTumor cell and stromal cell interactions during breast cancer progression
Noël, Agnès ULg; Foidart, Jean-Michel ULg

in Journal of Molecular Medicine (2002, September)

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