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See detailLa syncope
Mathieu, F.; Melon, Pierre ULg; Waleffe, André ULg et al

in Revue Médicale de Liège (2004), 59(5), 311-4

Syncope remains a clinical challenge. Accurate history taking, physical examination and EKG are mainstays of the diagnosis work up. The most important parameter for prognosis and requiring aggressive ... [more ▼]

Syncope remains a clinical challenge. Accurate history taking, physical examination and EKG are mainstays of the diagnosis work up. The most important parameter for prognosis and requiring aggressive management is a structural heart disease. Patient without cardiopathy presenting multiple episodes may be candidate for tilt testing and loop EKG recorder. [less ▲]

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See detailValidation of MIPAS N2O Profiles by Stratospherc Balloon, Aircraft and Ground Based Measurements
Camy-Peyret, C.; Dufour, G.; Payan, S. et al

Scientific conference (2004, May)

The ENVISAT validation programme for the atmospheric instruments MIPAS, SCIAMACHY and GOMOS is based on a number of balloon-bone, aircraft and ground-based correlative measurements. In particular the ... [more ▼]

The ENVISAT validation programme for the atmospheric instruments MIPAS, SCIAMACHY and GOMOS is based on a number of balloon-bone, aircraft and ground-based correlative measurements. In particular the activities of validation scientists were coordinated by ESA within the ENVISAT Stratospheric Aircraft and Balloon Campaign or ESABC. As a companion to a similar paper on CH4 and in parallel to the contribution of the individual validation teams, the resent paper provides a synthesis of comparisons performed between MIPAS N2O profiles roduced by the current ESA operational software (Instrument Processing Facility version 4.61 or IPF v4.61) or by the IMK-FZK scientific processor and correlative measurements obtained from balloon and aircraft experiments as well as from ground-based instruments. [less ▲]

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See detailComparisons between SCIAMACHY Scientific Products and Ground-Based FTIR Data for Total Columns of CO, CH4 and N2O
De Mazière, M.; Barret, B.; Blumenstock, T. et al

Scientific conference (2004, May)

Total column amounts of CO, CH4 and N2O retrieved from SCIAMACHY nadir observations in its near-infrared channels have been compared to data from a ground-based network of Fourier-transform infrared (FTIR ... [more ▼]

Total column amounts of CO, CH4 and N2O retrieved from SCIAMACHY nadir observations in its near-infrared channels have been compared to data from a ground-based network of Fourier-transform infrared (FTIR) spectrometers as well as to data obtained with an FTIR instrument during a ship cruise in January-February 2003, along the African West Coast. The SCIAMACHY data considered here have been produced by two different scientific retrieval algorithms, wfm-doas (version 4.0) and IMLM (version 5.1), and cover different time periods, making the number of reliable coincidences that satisfy the temporal and spatial collocation criteria rather limited and different for both. Also the quality of the SCIAMACHY Level 1 data, and thus of the Level 2 data for the different time periods is very different. Still the comparisons demonstrate the capability of SCIAMACHY, using one of both algorithms, to deliver geophysically valuable products for the target species under consideration, on a global scale. [less ▲]

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See detailEndothelin-1 is a critical mediator of myogenic tone in tumor arterioles: implications for cancer treatment.
Sonveaux, Pierre; Dessy; MARTINIVE, Philippe ULg et al

in Cancer Research (2004), 1(64), 3209-14

Although derived from the host tissue, the tumor vasculature is under the influence of the tumor microenvironment and needs to adapt to the resistance to blood flow inherent to the dynamics of tumor ... [more ▼]

Although derived from the host tissue, the tumor vasculature is under the influence of the tumor microenvironment and needs to adapt to the resistance to blood flow inherent to the dynamics of tumor growth. Such vascular remodeling can offer selective targets to pharmacologically modulate tumor perfusion and thereby improve the efficacy of conventional anticancer treatments. Radiotherapy and chemotherapy can, indeed, take advantage of a better tumor oxygenation and drug delivery, respectively, both partly dependent on the tumor blood supply. Here, we showed that isolated tumor arterioles mounted in a pressure myograph have the ability, contrary to size-matched healthy arterioles, to contract in response to a transluminal pressure increase. This myogenic tone was exquisitely dependent on the endothelin-1 pathway because it was completely abolished by the selective endothelin receptor A (ETA) antagonist BQ123. This selectivity was additionally supported by the large increase in endothelin-1 abundance in tumors and the higher density of the ETA receptors in tumor vessels. We also documented by using laser Doppler microprobes and imaging that administration of the ETA antagonist led to a significant increase in tumor blood flow, whereas the perfusion in control healthy tissue was not altered. Finally, we provided evidence that acute administration of the ETA antagonist could significantly stimulate tumor oxygenation, as determined by electron paramagnetic resonance oximetry, and increase the efficacy of low-dose, clinically relevant fractionated radiotherapy. Thus, blocking the tumor-selective increase in the vascular endothelin-1/ETA pathway led us to unravel an important reserve of vasorelaxation that can be exploited to selectively increase tumor response to radiotherapy. [less ▲]

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See detailAtteinte du nerf sus-scapulaire : corrélations entre l’évaluation isocinétique et l’ENMG
Goffinet, Estelle ULg; Mazza, Laetitia; Forthomme, Bénédicte ULg et al

in Neurophysiologie Clinique = Clinical Neurophysiology (2004, May), 34

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See detailElements of muscle's pathology in pediatrics
Battisti, Oreste ULg

Learning material (2004)

This presentations explains how to explore clinically and by investigations muscles movements and pathology, and how to treat muscles' spasticity in children

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See detailEvaluation of the group B differential agar for the detection of group B streptococci from vaginal specimens
MELIN, Pierrette ULg; Rodriguez Cuns, Grisel; Lorquet, Sophie et al

in American Society of Microbiology (Ed.) Program and Abstracts of the 104th General Meeting of the American Society for Microbiology (2004, May)

Background Group B streptococci (GBS) are the leading cause of severe perinatal infections. Most current guidelines for the prevention of GBS perinatal disease are based on prenatal screening culture for ... [more ▼]

Background Group B streptococci (GBS) are the leading cause of severe perinatal infections. Most current guidelines for the prevention of GBS perinatal disease are based on prenatal screening culture for vaginal GBS colonisation. Use of selective and differential media could improve the sensitivity of these cultures. Objective To evaluate the GBS-Differential Agar (GBSDA) recently formulated by Becton Dickinson for the selective growth and production of orange colonies of b- hemolytic (b-H) GBS. Methods 283 vaginal swabs (VAG) collected from pregnant women were inoculated in selective Lim broth. After overnight incubation, Lim broth were subcultured on GBSDA, on Granada agar (Biomedics, Spain) and on Columbia blood agar (BA). To evaluate the stability, 99 isolates of GBS (REF) from adult or neonatal infections (Belgian GBS reference laboratory collection) were cultured on GBSDA and Granada at their limit of expiration, and on BA. GBSDA and Granada were incubated anaerobically and BA aerobically + 7% CO2, at 35°C, 24 to 48 h. Positive and negative control strains (GBS ; E. faecalis) were cultured with each run. Specific identification of colonies suggestive of GBS (pale to dark orange on GBSDA and Granada, b-H on BA) was performed. Results b-H GBS were recovered from 63 VAG (22.3 %): 62 were easily identified after overnight incubation on GBSDA and 63 on Granada without requiring any subculture. All GBS were also recovered from BA however it was after many subcultures. All orange colonies were confirmed as GBS. Among REF, 3 strains were non hemolytic ; they grew but were not differentiated as orange colonies on GBSDA or Granada. 96 REF were b-H, 94 (97.9%) produced orange to very dark orange colonies on GBSDA, 2 produced white colonies, and on Granada, 74 (77.1 %) produced pale to dark orange colonies and 22 white to white-orange colonies. Conclusion 1) GBSDA and Granada: a) very high sensitivity and specificity for the detection of b-H GBS, in a single step b) Results available within 48 h after inoculation in Lim broth, low workload 2) Excellent stability up to expiration date for GBSDA 3) Non hemolytic GBS: grown but not differentiated on GBSDA or Granada. [less ▲]

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See detailL'attaque de panique
Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg

in Revue Médicale de Liège (2004), 59(5), 293-6

Panic attacks can occur unexpectedly and in almost any situation. The present article discusses the main features of anxiety states, the approach, the management and the practice guidelines for the ... [more ▼]

Panic attacks can occur unexpectedly and in almost any situation. The present article discusses the main features of anxiety states, the approach, the management and the practice guidelines for the treatment of panic disorder. [less ▲]

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See detailInfluence of methyl-b-cyclodextrin on the relase kinetics of inulin encapsulated in bioadhesive liposomes
Piel, Géraldine ULg; Boulmedarat, Laila; Bochot, Amélie et al

Poster (2004, May)

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See detailQuel avenir pour nos quartiers ?
Frankignoulle, Pierre ULg; Stevens, Barbara; Herold, Stefan

in Les Echos du logement (2004)

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See detailSecondary-structure characterization by far-UV CD of highly purified uncoupling protein 1 expressed in yeast
Douette, Pierre ULg; Navet, Rachel ULg; Bouillenne, Fabrice ULg et al

in Biochemical Journal (2004), 380(Pt 1), 139-145

The rat UCP1 (uncoupling protein 1) is a mitochondrial inner-membrane carrier involved in energy dissipation and heat production. We expressed UCP1 carrying a His(6) epitope at its C-terminus in ... [more ▼]

The rat UCP1 (uncoupling protein 1) is a mitochondrial inner-membrane carrier involved in energy dissipation and heat production. We expressed UCP1 carrying a His(6) epitope at its C-terminus in Saccharomyces cerevisiae mitochondria. The recombinant-tagged UCP1 was purified by immobilized metal-ion affinity chromatography to homogeneity (>95 %). This made it suitable for subsequent biophysical characterization. Fluorescence resonance energy transfer experiments showed that n-dodecyl-beta-D-maltoside-solubilized UCPI-His(6) retained its PN (purine nucleotide)-binding capacity. The far-UV CD spectrum of the functional protein clearly indicated the predominance of a-helices in the UCP1 secondary structure. The UCP1 secondary structure exhibited an alpha-helical degree of approx. 68 %, which is at least 25 % higher than the previously reported estimations based on computational predictions. Moreover, the helical content remained unchanged in free and PN-loaded UCP1. A homology model of the first repeat of UCP1, built on the basis of X-ray-solved close parent, the ADP/ATP carrier, strengthened the CD experimental results. Our experimental and computational results indicate that (i) alpha-helices are the major component of UCP1 secondary structure; (ii) PN-binding mechanism does not involve significant secondary-structure rearrangement; and (iii) UCP1 shares similar secondary-structure characteristics with the ADP/ATP carrier, at least for the first repeat. [less ▲]

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See detailHealth-related quality of life in total hip and total knee arthroplasty - A qualitative and systematic review of the literature
Ethgen, Olivier ULg; Bruyère, Olivier ULg; Richy, Florent et al

in Journal of Bone & Joint Surgery. American Volume (2004), 86(5), 963-974

BACKGROUND: Total hip and total knee arthroplasties are well accepted as reliable and suitable surgical procedures to return patients to function. Health-related quality-of-life instruments have been used ... [more ▼]

BACKGROUND: Total hip and total knee arthroplasties are well accepted as reliable and suitable surgical procedures to return patients to function. Health-related quality-of-life instruments have been used to document outcomes in order to optimize the allocation of resources. The objective of this study was to review the literature regarding the outcomes of total hip and knee arthroplasties as evaluated by health-related quality-of-life instruments. METHODS: The Medline and EMBASE medical literature databases were searched, from January 1980 to June 2003, to identify relevant studies. Studies were eligible for review if they met the following criteria: (1). the language was English or French, (2). at least one well-validated and self-reported health-related quality of life instrument was used, and (3). a prospective cohort study design was used. RESULTS: Of the seventy-four studies selected for the review, thirty-two investigated both total hip and total knee arthroplasties, twenty-six focused on total hip arthroplasty, and sixteen focused on total knee arthroplasty exclusively. The most common diagnosis was osteoarthritis. The duration of follow-up ranged from seven days to seven years, with the majority of studies describing results at six to twelve months. The Short Form-36 and the Western Ontario and McMaster University Osteoarthritis Index, the most frequently used instruments, were employed in forty and twenty-eight studies, respectively. Seventeen studies used a utility index. Overall, total hip and total knee arthroplasties were found to be quite effective in terms of improvement in health-related quality-of-life dimensions, with the occasional exception of the social dimension. Age was not found to be an obstacle to effective surgery, and men seemed to benefit more from the intervention than did women. When improvement was found to be modest, the role of comorbidities was highlighted. Total hip arthroplasty appears to return patients to function to a greater extent than do knee procedures, and primary surgery offers greater improvement than does revision. Patients who had poorer preoperative health-related quality of life were more likely to experience greater improvement. CONCLUSIONS: Health-related quality-of-life data are valuable, can provide relevant health-status information to health professionals, and should be used as a rationale for the implementation of the most adequate standard of care. Additional knowledge and scientific dissemination of surgery outcomes should help to ensure better management of patients undergoing total hip or total knee arthroplasty and to optimize the use of these procedures. [less ▲]

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See detailPlasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units
Delanaye, Pierre ULg; Lambermont, Bernard ULg; Chapelle, Jean-Paul ULg et al

in Intensive Care Medicine (2004), 30(5), 980-983

OBJECTIVE: To compare the sensitivity of cystatin C and creatinine in detecting decreased glomerular filtration rate. DESIGN: Prospective observational study. SETTING: Medical intensive care unit at a ... [more ▼]

OBJECTIVE: To compare the sensitivity of cystatin C and creatinine in detecting decreased glomerular filtration rate. DESIGN: Prospective observational study. SETTING: Medical intensive care unit at a university hospital. PATIENTS AND PARTICIPANTS: Fourteen patients hospitalised in a medical intensive care unit. INTERVENTIONS: Cystatin C and creatinine plasmatic levels were measured in 40 blood samples taken with an interval of at least 24 h. MEASUREMENTS AND RESULTS: Glomerular filtration rate was estimated by creatinine clearance using 24-h urine collection and the classical Cockcroft-Gault equation. The ability of cystatin C to detect a glomerular filtration rate under 80 ml/min per 1.73 m(2) was significantly better than that of creatinine ( p<0.05). CONCLUSIONS: Cystatin C, a new plasmatic marker of renal function, could be used to detect renal failure in intensive care in the future. [less ▲]

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See detailXMM-Newton observations of the giant H II region N 11 in the LMC
Nazé, Yaël ULg; Antokhin, I. I.; Rauw, Grégor ULg et al

in Astronomy and Astrophysics (2004), 418(3), 841-855

Using the sensitive XMM-Newton observatory, we have observed the giant H II region N11 in the LMC for similar to30 ks. We have detected several large areas of soft diffuse X-ray emission along with 37 ... [more ▼]

Using the sensitive XMM-Newton observatory, we have observed the giant H II region N11 in the LMC for similar to30 ks. We have detected several large areas of soft diffuse X-ray emission along with 37 point sources. One of the most interesting results is the possible association of a faint X-ray source with BSDL 188, a small extended object of uncertain nature, The OB associations in the field-of-view (LH9, LH10 and LH13) are all detected with XMM-Newton, but they appear very different from one another. The diffuse soft X-ray emission associated with LH9 peaks near HD 32228, a dense cluster of massive stars. The combined emission of all individual massive stars of LH9 and of the superbubble they have created is not sufficient to explain the high level of emission observed: hidden SNRs, colliding-wind binaries and the numerous pre-main sequence stars of the cluster are most likely the cause of this discrepancy. The superbubble may also be leaking some hot gas in the ISM since faint, soft emission can be observed to the south of the cluster. The X-ray emission from LH10 consists of three pointlike sources and a soft extended emission of low intensity. The two brightest point sources are clearly associated with the fastest expanding bubbles blown by hot stars in the SW part of the cluster. The total X-ray emission from LH10 is rather soft, although it presents a higher temperature than the other soft emissions of the field. The discrepancy between the combined emission of the stars and the observed luminosity is here less severe than for LH9 and could be explained in terms of hot gas filling the wind-blown bubbles. On the other hand, the case of LH13 is different: it does not harbour any extended emission and its X-ray emission could most probably be explained by the Sk -66degrees41 cluster alone. Finally, our XMM-Newton observation included simultaneous observations with the OM camera that provide us with unique UV photometry of more than 6000 sources and enable the discovery of the UV emission from the SNR N11L. [less ▲]

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See detailDefinition and Classification of Power System Stability
Kundur, Prabha; Paserba, John; Ajjarapu, Venkat et al

in IEEE Transactions on Power Systems (2004), 19(2), 1387-1401

The problem of defining and classifying power system stability has been addressed by several previous CIGRE and IEEE Task Force reports. These earlier efforts, however, do not completely reflect current ... [more ▼]

The problem of defining and classifying power system stability has been addressed by several previous CIGRE and IEEE Task Force reports. These earlier efforts, however, do not completely reflect current industry needs, experiences and understanding. In particular, the definitions are not precise and the classifications do not encompass all practical instability scenarios. This report developed by a Task Force, set up jointly by the CIGRE Study Committee 38 and the IEEE Power System Dynamic Performance Committee, addresses the issue of stability definition and classification in power systems from a fundamental viewpoint and closely examines the practical ramifications. The report aims to define power system stability more precisely, provide a systematic basis for its classification, and discuss linkages to related issues such as power system reliability and security. [less ▲]

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See detailChatter maps for process design of powertrain components
Masset, Luc ULg; Debongnie, Jean-François ULg; Belluco, Walter

in Moisan, Alphonse; Poulachon, Gérard (Eds.) Proceedings of the 7th CIRP International Workshop on Modeling of Machining Operations (2004, May)

During rough machining operations of powertrain components, chatter vibrations may occur on the edges of flexible structures. This paper presents a numerical method, based on the finite element method and ... [more ▼]

During rough machining operations of powertrain components, chatter vibrations may occur on the edges of flexible structures. This paper presents a numerical method, based on the finite element method and Tlusty's theory, which gives a chatter map of the machined surface. Each map point represents the greatest depth of cut leading to unconditionally stable cut. Each value depends on the structural damping, the cutting stiffness and the local static stiffness, which is computed using conventional linear elastic FEA. Chatter maps offer a convenient and effective decision support system for robust process design. As a case study, the rough milling operation of a crankcase deck face with a two-stage cutter is presented. [less ▲]

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See detailPrise en compte des pressions réparties dans les plaques équilibre
Debongnie, Jean-François ULg

Report (2004)

Equilibrium plate elements are not, in their simplest version, able to take account of a distributed pressure. A particular solution has then to be added. One such solution was develpped by Sander, but is ... [more ▼]

Equilibrium plate elements are not, in their simplest version, able to take account of a distributed pressure. A particular solution has then to be added. One such solution was develpped by Sander, but is only suitable for elements with first degree moments, as it makes use of the side Kirchhoff loads. This paper is devoted to the construction of a particular solution which is equilibrated by corner loads only and, therefore, compatible with the simplest plate element, that is Morley's one [less ▲]

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See detailSur le rang de la matrice de raideur de l'élément de tétraèdre statiqument admissible
Debongnie, Jean-François ULg

Report (2004)

This research concerns the rank of the stiffness matrix of the tetrahedral equilibrium element.

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See detailNew radioiodinated carboxylic and hydroxamic matrix metalloproteinase inhibitor tracers as potential tumor imaging agents
Oltenfreiter, R.; Staelens, L.; Lejeune, Annabelle ULg et al

in Nuclear Medicine & Biology (2004), 31(4), 459-468

Several studies have demonstrated a positive correlation between tumor progression and expression of extracellular proteinases such as matrix metalloproteinases (MMPs). MMP-2 and MMP-9 have become ... [more ▼]

Several studies have demonstrated a positive correlation between tumor progression and expression of extracellular proteinases such as matrix metalloproteinases (MMPs). MMP-2 and MMP-9 have become attractive targets for cancer research because of their increased expression in human malignant tumor tissues of various organs, providing a target for medical imaging techniques. Radioiodinated carboxylic and hydroxamic MMP inhibitors 2-(4'-[123]iodo-biphenyl-4-sulfonylainino)-3-(1H-indol-3-yl)-propionic acid (9) and 2-(4'-[I-123] iodo-biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide (11) were synthesized by electrophilic aromatic substitution of the tributylstannyl derivatives and resulted in radiochemical yields of 60% +/- 5% (n - 3) and 70% +/- 5% (n = 6), respectively. In vitro zymography and enzyme assays showed high inhibition capacities of the inhibitors on gelatinases. In vivo biodistribution showed no long-terin accumulation in organs and the possibility to accumulate in the tumor. These results warrant further studies of radioiodinated carboxylic and hydroxamic MNIP inhibitor tracers as potential SPECT tumor imaging agents. (C) 2004 Elsevier Inc. All rights reserved. [less ▲]

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