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See detailEvaluation of the endorcine disrupting chemicals contamination in the North Sea porpoise population using in vitro assays
Didimo Imazaki, Pedro Henrique ULg; Brose, François ULg; Van Der Heiden, Edwige ULg et al

Poster (2009)

During the last decades, the production endocrine disrupting chemicals reached such levels that they are now spread all over nature. They are known to be very slowly degraded, decreasing the environmental ... [more ▼]

During the last decades, the production endocrine disrupting chemicals reached such levels that they are now spread all over nature. They are known to be very slowly degraded, decreasing the environmental quality and posing ecological risks. Marine mammals inhabiting polluted environments accumulate high levels of these chemicals, so they can be considered good indicators of marine pollution. Thirteen major organochloride pollutants were chosen to make subject of this study: o,p’-DDD; p,p’-DDD; p,p’-DDE; o,p’-DDT; p,p’-DDT; HCB; α-HCH; β-HCH; γ-HCH; δ-HCH; PCB 138; PCB 153 and PCB 180. All these chemicals will have their endocrine disrupting effects characterized individually and collectively by report gene expression assays. The MCF7-ERE cells used in these assays were produced in the Molecular Biology and Genetic Engineering Laboratory of the University of Liège and are originated from a human mammary carcinoma. They carry a gene expressing the synthesis of luciferase and controlled by oestrogen receptors. Then, the thirteen chemicals will be searched in the blubber tissues of porpoises by the use of gas chromatography-mass spectrometry. The blubber samples will also have their endocrine disrupting effect characterized. For the moment, the estrogenic effects of the HCH isomers were put in evidence. The next steps of this work must be soon accomplished. It is expected a great level of these compounds to be found in the samples. On the other hand, their endocrine disrupting effects and how they act in agonist, antagonist and synergist ways are subject that still needs to be cleared. [less ▲]

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See detailRésolution du problème de contact mécanique frottant : méthode du lagrangien augmenté adapté
Bussetta, Philippe ULg; Marceau, Daniel; Ponthot, Jean-Philippe ULg

in Proceedings of “9ème Colloque National en Calcul des Structures (2009)

Cet article présente une nouvelle méthode de résolution du problème de contact mécanique frottant, celle du lagrangien augmenté adapté. Contrairement aux méthodes les plus utilisées (pénalisation et ... [more ▼]

Cet article présente une nouvelle méthode de résolution du problème de contact mécanique frottant, celle du lagrangien augmenté adapté. Contrairement aux méthodes les plus utilisées (pénalisation et lagrangien augmenté), l’utilisateur ne doit pas déterminer les valeurs des coefficients de pénalisation. Cette méthode est performante aussi bien avec des matériaux élastiques qu’élasto-plastiques. Le problème de Hertz est présenté. Cette méthode est au si utilisée dans le contexte multi-physique. [less ▲]

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See detailUsing Artificial Vision for the Microscopic Identification of Ores with Reflected Light: Preliminary Results.
Castroviejo, Ricardo; Brea, Carolina; Perez-Barnuevo, Laura et al

in Proceedings 10th Biennial SGA Meeting (2009)

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See detailHolocene environmental changes in lake sediments from Northern Chilean Patagonia
Nuttin; Fagel, Nathalie ULg; Brogniet et al

Poster (2009)

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See detailTowards a participative tool of decision-making aid as regards retail location-International Conference of Territorial Intelligence, Besançon 2008
Merenne-Schoumaker, Bernadette ULg; Devillet, Guénaël ULg; Jaspard, Mathieu ULg et al

in Papers on Tools and methods of Territorial Intelligence (2009)

Retail activities are more and more regulated. This regulation requires efficient management and decision support tools. In this framework, the University of Liège, in Belgium, work to implement this kind ... [more ▼]

Retail activities are more and more regulated. This regulation requires efficient management and decision support tools. In this framework, the University of Liège, in Belgium, work to implement this kind of tool on the Walloon Region. In this tool, a cartographic interface allows to locate, analyse and quantify retail supply.The interactive and multidimensional tool makes the diagnosis of a reference territory (the market area of a retail project) while permitting the implementation of a participative space regrouping the actors at least at two scales:intra communal and supra communal improving the governance in this sector. [less ▲]

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See detailAssessment Of Pichia Anomala (Strain K) Efficacy Against Blue Mould Of Apples When Applied Pre- Or Post-Harvest Under Laboratory Conditions And In Orchard Trials
Lahlali, R.; Massart, Sébastien ULg; De Clercq, D. et al

in European Journal of Plant Pathology (2009), 123(1), 37-45

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See detailOptimal age at first calving for improved milk yield and lengh of productive life in Tunisian Holstein cows
Ben Gara, Abderrahmen; Bouraoui, Rachid; Rekik, Boulbaba et al

in American-Eurasian Journal of Agronomy (2009), 2(3), 162-167

The effects of age at first calving on milk production and true herd life were studied in Tunisian Holstein cows. There were 33,407 first lactation records of cows born between 1987 and 2001 from 166 ... [more ▼]

The effects of age at first calving on milk production and true herd life were studied in Tunisian Holstein cows. There were 33,407 first lactation records of cows born between 1987 and 2001 from 166 herds. Firstly, age at first calving was analyzed using an animal model that included herd, calving year, herd-calving year interaction, calving month, and age of dam as fixed effects and the random additive genetic effect. Secondly, differences in first lactation and productive life milk yields and in true herd life were explained by age at first calving in addition to herd, year at first calving, herd-year at first calving interaction and month at first calving. A cow produced on the average 5669.8 kg milk (SD=1812 kg) during a 305-d first lactation period. The lifetime production of a cow was was 19,496.3 kg (SD=12,192 kg) during 3.3 lactations (SD=1.8 lactations). Coefficients of determination ranged from 14% for true herd life to 64% for first lactation milk yield. The mean of true herd life was 38.6 months (SD=24 months) and the mean age at first calving was 28.7 months (SD=3.4 months). Posterior mean of heritability of the age at first calving derived by a Markov Chain Monte Carlo Bayesien method via a Gibbs sampling algorithm was 0.08. The reduction of age at first calving to around 24 months may result in improved 305-d and lifetime yields and a longer herd life in Tunisian Holsteins. [less ▲]

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See detailConstraint Based Learning of Mixtures of Trees
Schnitzler, François ULg; Wehenkel, Louis ULg

Conference (2009)

Mixtures of trees can be used to model any multivariate distributions. In this work the possibility to learn these models from data by causal learning is explored. The algorithm developed aims at ... [more ▼]

Mixtures of trees can be used to model any multivariate distributions. In this work the possibility to learn these models from data by causal learning is explored. The algorithm developed aims at approximating all first order relationships between pairs of variables by a mixture of a given size. This approach is evaluated based on synthetic data, and seems promising. [less ▲]

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See detailDevelopment of an animal experimental model to study the effects of levonorgestrel on the human endometrium.
Alvarez Gonzalez, Maria-Luz ULg; Galant, C.; Frankenne, F. et al

in Human Reproduction (2009), 24(3), 697-704

BACKGROUND: This study was designed to develop an animal model to test the response of endometrium to local progestin delivery. METHODS: Proliferative human endometrium was subcutaneously grafted in two ... [more ▼]

BACKGROUND: This study was designed to develop an animal model to test the response of endometrium to local progestin delivery. METHODS: Proliferative human endometrium was subcutaneously grafted in two groups of SCID mice that received, 2 days before, a subcutaneous estradiol (E2) pellet and, for half of them, an additional implant of levonorgestrel (LNG). Mice were sacrificed 1, 2, 3 or 4 weeks after endometrial implantation and grafts were histologically analysed. Proliferation, steroid hormone receptors, blood vessels and stromal decidualization in both groups (E2 and LNG) were immunohistologically evaluated and compared with proliferative endometrium and endometrium from women with an LNG intrauterine device. RESULTS: Grafts presented normal morphological endometrial characteristics. The expression of progesterone receptors was significantly decreased in glands and stroma of the LNG group as compared with the E2 group at all times. A significant decrease was also observed in the stromal expression of estrogen receptor- in the LNG group. At 4 weeks, the mean cross-sectional area of vessels was significantly higher after LNG treatment. CONCLUSIONS: These morphological and immunohistochemical characteristics are similar to those observed in women treated with local LNG. This mouse model might facilitate further investigations needed to understand the mechanisms responsible for the breakthrough bleeding frequently observed in progestin users. [less ▲]

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See detailLes codes correcteurs
Rigo, Michel ULg

Learning material (2009)

Qu'on le veuille ou non, nous vivons dans un monde où les informations et les moyens de communication sont omniprésents. Les exemples où se mêlent informatique et télécommunications sont nombreux. Que ce ... [more ▼]

Qu'on le veuille ou non, nous vivons dans un monde où les informations et les moyens de communication sont omniprésents. Les exemples où se mêlent informatique et télécommunications sont nombreux. Que ce soit l'Internet, la musique achetée en ligne ou gravée sur CD, les baladeurs de type iPod et autres appareils portables, les supports mémoire de tout type, la photographie numérique, la présence d'ordinateurs de bord sophistiqués dans nos voitures, etc. Sans code correcteur, le CD (implémentant un code correcteur de type Reed-Solomon) et de nombreux autres produits n'auraient probablement jamais connu le succès ! [less ▲]

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See detailBIOLOGIE MOLECULAIRE APPLIQUEE A L’HOMME
Noël, Agnès ULg

Learning material (2009)

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See detailMixed origin of neovascularization of human endometrial grafts in immunodeficient mouse models
Alvarez Gonzalez, Maria-Luz ULg; Frankenne, F.; Galant, C. et al

in Human Reproduction (2009), 24(9), 2217-24

BACKGROUND: In vivo mouse models have been developed to study the physiology of normal and pathologic endometrium. Although angiogenesis is known to play an important role in endometrial physiology and ... [more ▼]

BACKGROUND: In vivo mouse models have been developed to study the physiology of normal and pathologic endometrium. Although angiogenesis is known to play an important role in endometrial physiology and pathology, the origin of neovasculature in xenografts remains controversial. The aim of this study was to assess the origin of the neovasculature of endometrial grafts in different mouse models. METHODS: Human proliferative endometrium (n = 19 women) was grafted s.c. in two immunodeficient mouse strains: nude (n = 8) and severely compromised immunodeficient (SCID; n = 20). Mice were also treated with estradiol, progesterone or levonorgestrel. Fluorescence in-situ hybridization using a centromeric human chromosome X probe, immunohistochemistry (von Willebrand factor and collagen IV) and lectin perfusion were performed to identify the origin of the vessels. RESULTS: More than 90% of vessels within xenografts were of human origin 4 weeks after implantation. Some vessels (9.67 +/- 2.01%) were successively stained by human or mouse specific markers, suggesting the presence of chimeric vessels exhibiting a succession of human and murine portions. No difference in staining was observed between the two strains of mouse or different hormone treatments. Furthermore, erythrocytes were found inside human vessels, confirming their functionality. CONCLUSION: This article shows that human endometrial grafts retain their own vessels, which connect to the murine vasculature coming from the host tissue and become functional. [less ▲]

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See detailLa copropriété
Lecocq, Pascale ULg

Book published by Anthemis (2009)

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See detailBalancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle.
Fasquelle, Corinne ULg; Sartelet, Arnaud ULg; Li, Wanbo et al

in PLoS Genetics (2009), 5(9), 1000666

We herein describe the positional identification of a 2-bp deletion in the open reading frame of the MRC2 receptor causing the recessive Crooked Tail Syndrome in cattle. The resulting frame-shift reveals ... [more ▼]

We herein describe the positional identification of a 2-bp deletion in the open reading frame of the MRC2 receptor causing the recessive Crooked Tail Syndrome in cattle. The resulting frame-shift reveals a premature stop codon that causes nonsense-mediated decay of the mutant messenger RNA, and the virtual absence of functional Endo180 protein in affected animals. Cases exhibit skeletal anomalies thought to result from impaired extracellular matrix remodeling during ossification, and as of yet unexplained muscular symptoms. We demonstrate that carrier status is very significantly associated with desired characteristics in the general population, including enhanced muscular development, and that the resulting heterozygote advantage caused a selective sweep which explains the unexpectedly high frequency (25%) of carriers in the Belgian Blue Cattle Breed. [less ▲]

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See detailEquivalent mixed model for joint genetic evaluation considering molecular and phenotypic information
Gengler, Nicolas ULg; Colinet, Frédéric ULg

in Journal of Dairy Science (2009), 92(E-suppl.1), 315

Currently efforts are underway to introduce molecular information into genetic evaluation systems. A particular situation is genomic selection however simpler cases exists where major genes are known and ... [more ▼]

Currently efforts are underway to introduce molecular information into genetic evaluation systems. A particular situation is genomic selection however simpler cases exists where major genes are known and used by breeders. A new alternative strategy for the prediction of gene effects and especially their smooth integration into genetic evaluations based on an equivalent method was developed from existing theory. Underlying hypothesis were based on the idea that knowledge of genotypes will not affect overall additive genetic variance but only change expected values of genetic effects for animals with known genotypes. The developed equations were modified to allow that not all animals were genotyped. As the underlying mixed model is open a very large range of models can be used in situations including random regression models, multipletrait, maternal effects and multiple-across-country-evaluation models. Computations involved successive solving of two mixed models, with the use of an linear extrapolation to speed up convergence of gene effects. The method was tested for several known major genes and QTL, e.g. for the mh gene in the dual-purpose Belgian Blue population in Belgium. Modifications of the method could also be developed to be useful in the context of genomic selection. [less ▲]

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