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See detailHIV-1 V3 envelope deep sequencing for clinical plasma specimens failing in phenotypic tropism assays.
Vandenbroucke, Ina; Van Marck, Herwig; Mostmans, Wendy et al

in AIDS Research and Therapy (2010), 7

ABSTRACT : BACKGROUND : HIV-1 infected patients for whom standard gp160 phenotypic tropism testing failed are currently excluded from co-receptor antagonist treatment. To provide patients with maximal ... [more ▼]

ABSTRACT : BACKGROUND : HIV-1 infected patients for whom standard gp160 phenotypic tropism testing failed are currently excluded from co-receptor antagonist treatment. To provide patients with maximal treatment options, massively parallel sequencing of the envelope V3 domain, in combination with tropism prediction tools, was evaluated as an alternative tropism determination strategy. Plasma samples from twelve HIV-1 infected individuals with failing phenotyping results were available. The samples were submitted to massive parallel sequencing and to confirmatory recombinant phenotyping using a fraction of the gp120 domain. RESULTS : A cut-off for sequence reads interpretation of 5 to10 times the sequencing error rate (0.2%) was implemented. On average, each sample contained 7 different V3 haplotypes. V3 haplotypes were submitted to tropism prediction algorithms, and 4/14 samples returned with presence of a dual/mixed (D/M) tropic virus, respectively at 3%, 10%, 11%, and 95% of the viral quasispecies. V3 tropism prediction was confirmed by gp120 phenotyping, except for two out of 4 D/M predicted viruses (with 3 and 95%) which were phenotypically R5-tropic. In the first case, the result was discordant due to the limit of detection for the phenotyping technology, while in the latter case the prediction algorithms were not computing the viral tropism correctly. CONCLUSIONS : Although only demonstrated on a limited set of samples, the potential of the combined use of "deep sequencing + prediction algorithms" in cases where routine gp160 phenotype testing cannot be employed was illustrated. While good concordance was observed between gp120 phenotyping and prediction of R5-tropic virus, the results suggest that accurate prediction of X4-tropic virus would require further algorithm development. [less ▲]

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See detailEuro-Thymaide - Final publishable report
Geenen, Vincent ULiege

Report (2010)

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See detailEuropees financieel toezicht tussen droom en daad: Enkele alternatieve suggesties in het licht van de financiële crisis
Van Cleynenbreugel, Pieter ULiege

in Jura Falconis (2010)

This reflection article looks at the emergence of a new institutional architecture in the organisation of financial supervision in the European Union, especially in the wake of the 2008 banking crisis.

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See detailContributions du sommeil a la consolidation mnésique
Maquet, Pierre ULiege; Matarazzo; Foret, Ariane ULiege et al

in Biologie Aujourd'hui (2010), 204(2), 139-143

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See detailEstimating pCO2 from remote sensing in the Belgian Coastal Zone
Borges, Alberto ULiege; Ruddick, K.; Lacroix, G. et al

in ESA Living Planet Symposium : 28 June - 2 July 2010, Bergen, Norway (2010)

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See detailEnhanced proof strength after cold process of fabrication of non-linear metallic profiles – Comparison of two predictive models for hollow sections
Rossi, Barbara ULiege; Jaspart, Jean-Pierre ULiege

in International Symposium on Tubular Structures : ISTS13, Hong Kong, 15-17 December 2010 (2010)

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See detailElectrical resistivity tomography and self-potential case studies for fractured aquifer characterization and monitoring
Robert, Tanguy ULiege; Dassargues, Alain ULiege; Nguyen, Frédéric ULiege

in Geophysical Research Abstracts (2010), 12

Electrical resistivity tomography (ERT) and self-potential (SP) investigations have been conducted in complex carboniferous limestones aquifers in Belgium (synclinorium structures). The aims of this study ... [more ▼]

Electrical resistivity tomography (ERT) and self-potential (SP) investigations have been conducted in complex carboniferous limestones aquifers in Belgium (synclinorium structures). The aims of this study were (1) to detect and characterize fractured zones in hard rock aquifers, (2) to monitor groundwater flow/water content in these fractured or karstic areas and (3) to use geophysical data to support groundwater flow model set-up and calibration. The investigated areas lie in calcareous synclines. Electrical images allowed us to detect and characterize (in terms of direction, width and depth) several less resistive anomalies, which are interpreted in terms of fractured and/or karstic zones. To interpret the ERT images, data errors as well as image appraisal indicators (resolution matrix, sensitivity matrix and DOI index) were analysed and compared. This allowed us to determine the depth of investigation of ERT and to avoid the misinterpretation of the resulting images. Inversions based on focusing scheme are tested against smoothness-constraint inversion on these field data to provide more realistic images on the basis of prior geological knowledge. Self-potential measurements were performed along the electrical profiles and allowed us to find negative anomalies possibly related with groundwater preferential flow pathways. By taking the assumption that only the electrokinetic effect plays a role in the SP signals, we were able to estimate a first distribution of the water table along our profiles. The SP data showed that in this particular tectonic structure, two perpendicular hydraulic gradients are present. The first gradient is related with the main fold axis direction and is the major drainage system. The second hydraulic gradient is related with the flanks of the calcareous valley. Geophysical data concurrently with ‘ground truth’ geological and hydrogeological data allowed us to better understand the groundwater flow in these calcareous synclines and to verify the conceptual groundwater flow model. [less ▲]

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See detailAnalyser les relations hyperconflictuelles entre groupes sociaux : des organisations au domaine politique
Faulx, Daniel ULiege; Danse, Cédric ULiege

in Piet, Grégory; Wintgens, Sophie (Eds.) Analyse des conflits et leur résolution (2010)

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See detailUsing time-dependent reference profiles for an instability analysis of an evaporating binary liquid layer
Machrafi, Hatim ULiege; Rednikov, Alexey; Colinet, Pierre et al

Poster (2010)

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See detailLandscape Capacity and Social Attitude towards wind energy projects in Belgium
Van Rompaey; Schmitz, Serge ULiege; Kestelot, C.

Report (2010)

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See detailGénération de maillages éléments finis d’ordre élevé
Johnen, Amaury ULiege

Master's dissertation (2010)

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See detailRésumé Cour constitutionnelle n°135/2009, du 1er septembre 2009
Delnoy, Michel ULiege

in Aménagement - Environnement (2010), 1

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See detailRésumé C.E. n°195.050, du 2 juillet 2009, Pringels
Delnoy, Michel ULiege

in Aménagement - Environnement (2010), 1

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See detailRésumé Liège, 20 janvier 2009, Région wallonne c/ N.V. Immo Ter Kouter
Delnoy, Michel ULiege

in Aménagement - Environnement (2010), 1

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See detailLes points faibles du dispositif "assuétudes"
Vandoorne, Chantal ULiege; Cherbonnier, Alain; Taeymans, Bernadette et al

in Cahiers de Prospective Jeunesse (2010), 56

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