Publications ORBi OA
Bookmark and Share    
Full Text
Peer Reviewed
See detailDeep infection by Trichophyton rubrum in an immunocompromised patient.
Nir-Paz, Ran; Elinav, Hila; Pierard, Gérald ULg et al

in Journal of Clinical Microbiology (2003), 41(11), 5298-301

Dermatophytes are common pathogens of skin but rarely cause invasive disease. We present a case of deep infection by Trichophyton rubrum in an immunocompromised patient. T. rubrum was identified by ... [more ▼]

Dermatophytes are common pathogens of skin but rarely cause invasive disease. We present a case of deep infection by Trichophyton rubrum in an immunocompromised patient. T. rubrum was identified by morphological characteristics and confirmed by PCR. Invasiveness was apparent by histopathology and immunohistochemistry. The patient was treated successfully with itraconazole. [less ▲]

Detailed reference viewed: 41 (0 ULg)
Full Text
Peer Reviewed
See detailL'image du mois. Myiase furonculoide americaine.
Leonard, Philippe ULg; Martalo, O.; Pierard, Gérald ULg

in Revue Médicale de Liège (2003), 58(12), 721-2

Detailed reference viewed: 83 (0 ULg)
Full Text
Peer Reviewed
See detailSkin weathering and ashiness in black Africans.
Uhoda, Emmanuelle ULg; Pierard, Claudine ULg; Petit, Ludivine et al

in European Journal of Dermatology (2003), 13(6), 574-8

Ashiness describes a common physiological skin condition that may develop in people with dark skin complexion. Environmental influences, particularly cold and dry weather, seem obvious. This condition has ... [more ▼]

Ashiness describes a common physiological skin condition that may develop in people with dark skin complexion. Environmental influences, particularly cold and dry weather, seem obvious. This condition has seldom been studied so far. In the present study, skin ashiness was assessed in 37 black African women by means of colorimetric assessments and xerosis ratings. Colour changes were measured by the parameters a* and the individual typology angle ITA degrees. Xerosis was assessed by visual inspection, the ultraviolet light-enhanced visualization (ULEV) method, and the cyanoacrylate skin surface stripping (CSSS) method. The assessments were performed on ashy skin of the legs and on the normal looking forehead during the winter season. Ashy skin was lighter but not erythematous. The ITA-revealed colour changes were correlated with xerosis severity as assessed by dry dermoscopy and by the ULEV and CSSS methods. In conclusion, ashiness due to skin weathering does not appear to be related to mild inflammation. It corresponds to a peculiar type of xerosis with reduction in Fresnel reflection by the stratum corneum. [less ▲]

Detailed reference viewed: 42 (0 ULg)
Full Text
Peer Reviewed
See detailKeys to promote Good Practices in ODL by a TECC Approach (Training Embedded Coached Course Construction): Illustrations through a Postgraduate Degree and an Annual Competitive Call
Poumay, Marianne ULg

in Educational Media International (2003), 40(3-4), 229-237

The article presents two parallel initiatives contributing to an open and distance learning (ODL) deployment, comparing them using the LabSET Keys to implement a Training Embedded Coached Course ... [more ▼]

The article presents two parallel initiatives contributing to an open and distance learning (ODL) deployment, comparing them using the LabSET Keys to implement a Training Embedded Coached Course Construction (TECCC) approach. The article examines some of the challenges faced by the support to trainers using the Web as an instructional tool to facilitate learner-centered practices. It includes a definition of "quality courses". [less ▲]

Detailed reference viewed: 25 (3 ULg)
Full Text
See detailLa motivation: Un élément central dans la vie des associations sportives
Cloes, Marc ULg

in Maes, Marc; Zintz, Thierry (Eds.) Vademecum. Management du sport. 2ème Edition (2003)

La motivation constitue un élément indispensable dans le succès sportif. Elle intervient au niveau de tous les acteurs de la vie sportive: athlètes, entraîneurs et bénévoles. Ce chapitre propose une ... [more ▼]

La motivation constitue un élément indispensable dans le succès sportif. Elle intervient au niveau de tous les acteurs de la vie sportive: athlètes, entraîneurs et bénévoles. Ce chapitre propose une présentation des principes généraux liés à la motivation et des illustrations de son implication en milieu sportif. [less ▲]

Detailed reference viewed: 244 (9 ULg)
Full Text
Peer Reviewed
See detailIntensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
Tilly, Hervé; Lepage, Eric; Coiffier, Bertrand et al

in Blood (2003), 102(13), 4284-4289

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide ... [more ▼]

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in previously untreated patients with poor-risk aggressive lymphoma. Patients aged 61 to 69 years who had aggressive non-Hodgkin lymphoma with at least one prognostic factor of the age-adjusted international prognostic index (IPI) were included. ACVBP consisted of an induction phase of intensified chemotherapy and central nervous system (CNS) prophylaxis followed by a sequential consolidation phase. Of the 708 patients registered for the study, 635 were eligible. The rate of complete response was 58% in the ACVBP group and 56% in the CHOP group (P =.5). Treatment-related death occurred in 13% of the ACVBP group and 7% of the CHOP group (P =.014). At 5 years, the event-free survival was 39% in the ACVBP group and 29% in the CHOP group (P =.005). The overall survival was significantly longer for patients treated with ACVBP, at 5 years it was 46% compared with 38% for patients treated with CHOP (P =.036). CNS progressions or relapses were more frequent in the CHOP group (P =.004). Despite higher toxicity, the ACVBP regimen, used as first-line treatment for patients with poor-risk aggressive lymphoma, is superior to standard CHOP with regard to both event-free survival and overall survival. (C) 2003 by The American Society of Hematology. [less ▲]

Detailed reference viewed: 101 (0 ULg)
Full Text
Peer Reviewed
See detailPathophysiology of type 2 diabetes.
Scheen, André ULg

in Acta Clinica Belgica (2003), 58(6), 335-41

Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat metabolism. The causes of type 2 diabetes are multi-factorial and include both genetic and ... [more ▼]

Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat metabolism. The causes of type 2 diabetes are multi-factorial and include both genetic and environmental elements that affect beta-cell function and tissue (muscle, liver, adipose tissue, pancreas) insulin sensitivity. Although there is considerable debate as to the relative contributions of beta-cell dysfunction and reduced insulin sensitivity to the pathogenesis of diabetes, it is generally agreed that both these factors play important roles. However, the mechanisms controlling the interplay of these two impairments are unclear. A number of factors have been suggested as possibly linking insulin resistance and beta-cell dysfunction in the pathogenesis of type 2 diabetes. A majority of individuals suffering from type 2 diabetes are obese, with central visceral adiposity. Therefore, the adipose tissue should play a crucial role in the pathogenesis of type 2 diabetes. Although the predominant paradigm used to explain this link is the portal/visceral hypothesis giving a key role in elevated non-esterified fatty acid concentrations, two new emerging paradigms are the ectopic fat storage syndrome (deposition of triglycerides in muscle, liver and pancreatic cells) and the adipose tissue as endocrine organ hypothesis (secretion of various adipocytokins, i.e. leptin, TNF-alpha, resistin, adiponectin, implicated in insulin resistance and possibly beta-cell dysfunction). These two paradigms constitute the framework for the study of the interplay between insulin resistance and beta-cell dysfunction in type 2 diabetes as well as between our obesogenic environment and diabetes risk in the next decade. [less ▲]

Detailed reference viewed: 3019 (2 ULg)
Full Text
Peer Reviewed
See detailA randomized study over 13 cycles to assess the influence of oral contraceptives containing ethinylestradiol combined with drospirenone or desogestrel on carbohydrate metabolism.
Gaspard, Ulysse ULg; Scheen, André ULg; Endrikat, J. et al

in Contraception (2003), 67(6), 423-9

In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (Yasmin) with a reference preparation containing 30 ... [more ▼]

In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (Yasmin) with a reference preparation containing 30 microg ethinylestradiol and 150 microg desogestrel (Marvelon) on variables of carbohydrate metabolism by means of oral glucose tolerance tests at baseline and in the 6th and 13th treatment cycle. The mean levels of fasting glucose and insulin were similar at baseline and after 13 treatment cycles, whereas C-peptide and free fatty acid levels decreased slightly in both groups. All blood glucose and insulin values measured in the oral glucose tolerance tests were within normal ranges, despite a slight increase in the mean areas under the curves of 0-3 h [AUCs (0-3 h)] of both variables from baseline to treatment cycle 13. Differences between both treatments were not statistically significant. The mean AUCs (0-3 h) for C-peptide were not markedly changed in any treatment group. Free fatty acid levels decreased by 42% in the drospirenone group and increased by 48.9% in the desogestrel group, in terms of means of individual changes. Both preparations were well tolerated and equally efficacious regarding contraception and cycle control. The mean body weight was slightly decreased in most cycles during treatment with the drospirenone combination, as compared to baseline, while it was slightly increased versus baseline in all cycles during treatment with the desogestrel combination. The combination with drospirenone had less impact on blood pressure than the combination with desogestrel. In conclusion, Yasmin, a combined low-dose oral contraceptive with 30 microg ethinylestradiol and 3 mg of the novel progestogen drospirenone, as well as the reference Marvelon, containing 30 microg ethinylestradiol and 150 microg desogestrel had little impact on carbohydrate metabolism when used for 1 year. The observed changes were small and not suggestive of a clinically relevant deterioration of carbohydrate metabolism. [less ▲]

Detailed reference viewed: 50 (3 ULg)
Full Text
Peer Reviewed
See detailEffect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIER.
Mogensen, Carl Erik; Viberti, Giancarlo; Halimi, Serge et al

in Hypertension (2003), 41(5), 1063-71

Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril ... [more ▼]

Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril monotherapy on albumin excretion rate (AER) in patients with type 2 diabetes, albuminuria, and hypertension in a 12-month, randomized, double-blind, parallel-group international multicenter study. Four hundred eighty-one patients with type 2 diabetes and hypertension (systolic BP > or =140 mm Hg, <180 mm Hg, diastolic BP <110 mm Hg) were randomly assigned (age 59+/-9 years, 77% previously treated for hypertension). Results from 457 patients (intention-to-treat analysis) were available. After a 4-week placebo period, patients with albuminuria >20 and <500 microg/min were randomly assigned to a combination of 2 mg perindopril/0.625 mg indapamide or to 10 mg daily enalapril. After week 12, doses were adjusted on the basis of BP to a maximum of 8 mg perindopril/2.5 mg indapamide or 40 mg enalapril. The main outcome measures were overnight AER and supine BP. Both treatments reduced BP. Perindopril/indapamide treatment resulted in a statistically significant higher fall in both BP (-3.0 [95% CI -5.6, -0.4], P=0.012; systolic BP -1.5 [95% CI -3.0, -0.1] diastolic BP P=0.019) and AER -42% (95% CI -50%, -33%) versus -27% (95% CI -37%, -16%) with enalapril. The greater AER reduction remained significant after adjustment for mean BP. Adverse events were similar in the 2 groups. Thus, first-line treatment with low-dose combination perindopril/indapamide induces a greater decrease in albuminuria than enalapril, partially independent of BP reduction. A BP-independent effect of the combination may increase renal protection. [less ▲]

Detailed reference viewed: 127 (4 ULg)
Full Text
Peer Reviewed
See detailTreatment of type 2 diabetes.
Scheen, André ULg

in Acta Clinica Belgica (2003), 58(5), 318-24

Type 2 diabetes is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. As most subjects are overweighted or obese, the initial treatment ... [more ▼]

Type 2 diabetes is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. As most subjects are overweighted or obese, the initial treatment is optimization of the meal plan and enhancement of physical activity in order to obtain sustained weight reduction. In case of failure of life-style changes, various oral antihyperglycaemic agents may be used. Some are targeting defective insulin secretion (sulphonylureas, glinides) while others are targeting insulin resistance (metformin, thiazolidinediones). Criteria of drug selection should include both patient's characteristics (body weight, age, degree of hyperglycaemia, comorbidities) and pharmacological properties of the compound (mode of action, safety profile, cost). Monotherapy is usually recommended first, but combined therapy using drugs with additive or synergistic effects may be required to obtain appropriate blood glucose control. As the natural history of the disease is characterized by a progressive exhaustion of beta cells, exogenous insulin may be required in the long term, usually in combination with oral agents. Finally, as patients with type 2 diabetes are insulin-resistant and often have a metabolic syndrome, a multifactorial intervention including aggressive treatment of arterial hypertension and dyslipidaemia is recommended in order to reduce the incidence of cardiovascular complications. [less ▲]

Detailed reference viewed: 358 (1 ULg)
Full Text
Peer Reviewed
See detailPrevention of cardiovascular disease: plea for a rationale use of diet and lipid-lowering drugs.
Scheen, André ULg

in Acta Clinica Belgica (2003), 58(3), 149-51

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailPreventing, delaying, or masking type 2 diabetes with metformin in the diabetes prevention program?
Scheen, André ULg

in Diabetes Care (2003), 26(9), 27012701-3

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailNonalcoholic steatohepatitis and insulin resistance: interface between gastroenterologists and endocrinologists.
Scheen, André ULg; Luyckx, Françoise ULg

in Acta Clinica Belgica (2003), 58(2), 81-91

Nonalcoholic steatohepatitis (NASH), along with other forms of nonalcoholic fatty liver disease, is an increasingly common clinico-pathological syndrome. It is frequently associated with obesity ... [more ▼]

Nonalcoholic steatohepatitis (NASH), along with other forms of nonalcoholic fatty liver disease, is an increasingly common clinico-pathological syndrome. It is frequently associated with obesity, especially visceral fat, and type 2 diabetes, and is intimately related to markers of the insulin resistance syndrome. Both the prevalence and the severity of liver steatosis are related to body mass index, waist circumference, hyperinsulinaemia, hypertriglyceridemia and impaired glucose tolerance. The pathophysiology of NASH involves two steps: 1) insulin resistance, which causes steatosis; 2) and oxidative stress, which produces lipid peroxidation and activates inflammatory cytokines. The identification of subjects who may progress from fatty liver to NASH, and from NASH to fibrosis/cirrhosis is an important clinical challenge as well as the finding of appropriate therapy that could prevent such deleterious process. Substantial weight loss is accompanied by a marked attenuation of insulin resistance and related metabolic syndrome and, concomitantly, by an important regression of liver steatosis in most patients, although mild inflammation may be detected in some subjects. Thus, NASH may be considered as another disease of affluence, as is the insulin resistance syndrome and perhaps being part of it. [less ▲]

Detailed reference viewed: 94 (1 ULg)
Full Text
See detailInnovations dans l'enseignement musical : apports et limites des cours d'instruments semi-collectifs. Pistes de réflexion et d'action
Giot, Bernadette ULg; Baye, Ariane ULg

in Site du Ministère de la Communauté française de Belgique (2003)

Detailed reference viewed: 42 (2 ULg)
Full Text
See detailL’intervention dans les Activités physiques et sportives : rétro/perspectives
Cloes, Marc ULg

Book published by ULg - Département des activités physiques et sportives - N° dépôt légal : D/2003/10.095/1 (2003)

L’intervention dans les Activités Physiques et Sportives (APS) est associée par certains à la Pédagogie du Sport. D’autres la considèrent comme un domaine plus vaste qui dépasse la transmission de ... [more ▼]

L’intervention dans les Activités Physiques et Sportives (APS) est associée par certains à la Pédagogie du Sport. D’autres la considèrent comme un domaine plus vaste qui dépasse la transmission de connaissances, le développement de savoirs-faire, de savoir-être ou de compétences. Elle concerne ainsi un nombre important de personnes qui s’engagent dans l’organisation de la pratique. Les domaines concernés dépassent largement le cadre de l’enseignement de l’éducation physique puisque la motricité humaine prend pied dans bien d’autres formes de pratique : l’entraînement, l’animation sportive, la rééducation, la psychomotricité. Logiquement, les recherches qui portent sur l’Intervention dans les APS s’engagent dans des directions très variées, focalisées sur les multiples facettes des environnements composites où elle s’exerce. Le colloque avait pour objectif premier de faire le point sur les approches existantes, leurs apports et l’évolution qui semble se dessiner actuellement. Cette mission traditionnelle de l’institution universitaire relève du besoin majeur de diffuser les connaissances acquises et d’en susciter l’exploitation. Toutefois, dans son discours, le monde académique n’adopte pas toujours une logique qui rencontre celle de l’univers professionnel dans le sens où les praticiens confrontés à des situations exigeant une adaptation immédiate ne se retrouvent pas nécessairement dans le développement raisonné des scientifiques. Partant du principe que les deux mondes devraient apprendre à se parler davantage pour mieux se comprendre et bénéficier de leurs richesses respectives, les organisateurs ont également souhaité que cette manifestation devienne un carrefour permettant aux chercheurs de jeter des ponts vers les praticiens et à ceux-ci de faire part de leur expertise. D’emblée, afin d’atteindre cet objectif, il est apparu que la formule des « posters » devait être privilégiée. Cette forme de communication qui exploite des modes d’information complémentaires s’avère en effet particulièrement propice aux échanges. Elle connaît d’ailleurs un succès croissant dans le monde scientifique. Par un engagement particulièrement actif, des individus parviennent à insuffler à un champ de recherche une énergie qui lui permet de se développer de manière aussi considérable qu’imprévisible. Dans le domaine de l’Intervention dans les APS, ce scénario s’est vérifié et il est indéniable que le Professeur Maurice Piéron, dont la carrière à l’Université de Liège prend fin cette année, y a tenu l’un des rôles principaux. Il semblait donc opportun de souligner l’événement en illustrant le chemin parcouru depuis le moment où la Pédagogie du Sport était encore une discipline confidentielle. [less ▲]

Detailed reference viewed: 128 (10 ULg)
Full Text
See detailAnalyses édumétriques et indices métacognitifs appliqués aux questions des 10 check-up Mohican
Leclercq, Dieudonné ULg; Poumay, Marianne ULg

in Leclercq, Dieudonné (Ed.) Diagnostic cognitif et métacognitif au seuil de l'université : le projet Mohican menée par les 9 universités de la Communauté française Wallonie-Bruxelles (2003)

Detailed reference viewed: 54 (4 ULg)
Full Text
Peer Reviewed
See detailAn empirical comparison of machine learning algorithms for generic image classification
Marée, Raphaël ULg; Geurts, Pierre ULg; Visimberga, Giorgio et al

in Proceedings of the 23rd SGAI international conference on innovative techniques and applications of artificial intelligence, Research and development in intelligent systems XX, (2003)

Detailed reference viewed: 34 (2 ULg)
Full Text
Peer Reviewed
See detailGranulometría y Morfometría de Materiales Granulares por Metódos Ópticos
Pirard, Eric ULg

in Avila, Margot; Lucion, Christian (Eds.) Mineria, Metalurgia y Medio Ambiente (2003)

Detailed reference viewed: 39 (0 ULg)
Full Text
Peer Reviewed
See detailDevelopment of pure prolactin receptor antagonists
Bernichtein, Sophie; Kayser, Christine; Dillner, Karin et al

in Journal of Biological Chemistry (2003), 278(38), 35988-99

Prolactin (PRL) promotes tumor growth in various experimental models and leads to prostate hyperplasia and mammary neoplasia in PRL transgenic mice. Increasing experimental evidence argues for the ... [more ▼]

Prolactin (PRL) promotes tumor growth in various experimental models and leads to prostate hyperplasia and mammary neoplasia in PRL transgenic mice. Increasing experimental evidence argues for the involvement of autocrine PRL in this process. PRL receptor antagonists have been developed to counteract these undesired proliferative actions of PRL. However, all forms of PRL receptor antagonists obtained to date exhibit partial agonism, preventing their therapeutic use as full antagonists. In the present study, we describe the development of new human PRL antagonists devoid of agonistic properties and therefore able to act as pure antagonists. This was demonstrated using several in vitro bioassays, including highly sensitive assays able to detect extremely low levels of receptor activation. These new compounds also act as pure antagonists in vivo, as assessed by analyzing their ability to competitively inhibit PRL-triggered signaling cascades in various target tissues (liver, mammary gland, and prostate). Finally, by using transgenic mice expressing PRL specifically in the prostate, which exhibit constitutively activated signaling cascades paralleling hyperplasia, we show that these new PRL analogs are able to completely revert PRL-activated events. These second generation human PRL antagonists are good candidates to be used as inhibitors of growth-promoting actions of PRL. [less ▲]

Detailed reference viewed: 24 (3 ULg)
Full Text
Peer Reviewed
See detailInfluence of response factors on determining equilibrium association constants of non-covalent complexes by electrospray ionization mass spectrometry
Gabelica, Valérie ULg; Galic, Nives; Rosu, Frédéric ULg et al

in Journal of Mass Spectrometry [=JMS] (2003), 38(5), 491-501

A method for determining the equilibrium association constant of a complexation reaction A + B <=> AB by electrospray ionization mass spectrometry is described. The method consists in measuring the ... [more ▼]

A method for determining the equilibrium association constant of a complexation reaction A + B <=> AB by electrospray ionization mass spectrometry is described. The method consists in measuring the relative intensities of the peaks corresponding to A and to AB in equimolar A–B solutions at different concentrations C0. The results are fitted by a non-linear least-squares procedure, with the two variable parameters being the equilibrium association constant Ka and a factor R, defined by I(AB)/I.A/ = R× [AB]/[A]. The factor R is the ratio between the response factors of AB and A, and corrects for the relative electrospray responses of the complex and the free substrate A, mass discrimination of instrumental origin and/or moderate in-source dissociation. The method is illustrated with the following two systems: complexes between a double-stranded 12-base pair oligonucleotide and minor groove binders, and cyclodextrin complexeswith a,!-dicarboxylic acids. For the oligonucleotide complexes, it is found that the response of the complex is not dramatically different to the response of the free oligonucleotide duplex, as the double helix conformation is disturbed by the drug only to a minor extent. In the case of cyclodextrin complexes, these complexes were found to have a much higher response than free cyclodextrin. This may be due to the fact that cyclodextrin is neutral in solution, whereas the complex is charged, but it can also stem from the fact that a significant proportion of the complex is in a non-inclusion geometry. The present method requires the exact determination of the concentrations of the reactants and is applicable to 1 : 1 complexes. [less ▲]

Detailed reference viewed: 60 (5 ULg)