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See detailHypertension et diabète
Krzesinski, Jean-Marie ULg; Weekers, Laurent ULg

in Revue Médicale de Liège (2005), 60(5-6, May-Jun), 572-577

Hypertension frequently accompanies diabetes mellitus, as it is present in 50% of diabetic patients. Hypertension can sometimes preceed diabetes. In type 2 diabetes, insulin resistance plays a major role ... [more ▼]

Hypertension frequently accompanies diabetes mellitus, as it is present in 50% of diabetic patients. Hypertension can sometimes preceed diabetes. In type 2 diabetes, insulin resistance plays a major role in the hypertensive risk. In type 1 diabetes, nephropathy is often noted as soon as hypertension is present. Both hypertension and diabetes increase the risk for cardiovascular and renal complications. For their prevention, first of all, modification of the diet with increasing exercise must be proposed, associated to antihypertensive agents with a blood pressure target lower than 130/80 mmHg. Renin-angiotensin blockers constitute the main drug therapy in such patients associated with diuretics or betablocker if angina pectoris is present or even calcium channel blocker when large arteries abnormalities exist. A frequent evaluation of the cardiovascular risk is required together with research of renal dysfunction or microproteinuria. [less ▲]

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See detailYB-1 represses AP1-dependent gene transactivation and interacts with an AP-1 DNA sequence.
Samuel, Shaija; Twizere, Jean-Claude ULg; Bernstein, Lori R

in Biochemical Journal (2005), 388(Pt 3), 921-8

Involvement of the AP-1 (activator protein-1) transcription factor has been demonstrated previously in the regulation of cell proliferation and cell-cycle progression, in the control of cell migration ... [more ▼]

Involvement of the AP-1 (activator protein-1) transcription factor has been demonstrated previously in the regulation of cell proliferation and cell-cycle progression, in the control of cell migration, invasion and metastasis, and in signal transduction, stress responsiveness, DNA replication and DNA repair. YB-1 (Y-box-binding protein-1) has also been implicated in many of these processes. However, the mechanism by which YB-1 mediates these processes is poorly understood. In the present study, we report that overexpression of a transfected gene encoding YB-1 in human HeLa cervical carcinoma cells significantly represses the transactivation of a minimal AP-1 reporter construct in response to the tumour promoter PMA. YB-1 also represses mRNA expression and PMA-induced promoter transactivation of the endogenous AP-1 target gene encoding matrix metalloproteinase-12 (metalloelastase). YB-1 transrepression of both the minimal and matrix metalloproteinase-12 promoter reporter constructs is dependent on the AP-1 sequence. To identify new nuclear proteins that bind specifically to the AP-1 DNA-binding site, we devised a DNA-affinity-chromatography-based assay termed NAPSTER (nucleotide-affinity preincubation specificity test of recognition) and discovered a 49 kDa protein from human cancer cells that binds in a sequence-specific manner to the AP-1 DNA sequence. By tandem MS fragmentation sequencing analyses we determined that p49 is a YB-1. Immunoblotting of the NAPSTER-purified p49 protein using anti-YB-1 antibodies confirmed YB-1 binding to the AP-1 DNA sequence, as did gel mobility-supershift assays using YB-1 antibodies. This is the first report of YB-1 transrepression and interaction at the AP-1 DNA-binding site. [less ▲]

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See detailModern techniques for flood risk analysis: quasi-3D simulations in a GIS environment
Archambeau, Pierre ULg; Erpicum, Sébastien ULg; Dewals, Benjamin ULg et al

in Geophysical Research Abstracts (2005), 7(09348),

Human beings have continuously attempted to adapt their environment to their needs. However, many natural phenomena still remain challenging to control and the populations must undergo sometimes heavily ... [more ▼]

Human beings have continuously attempted to adapt their environment to their needs. However, many natural phenomena still remain challenging to control and the populations must undergo sometimes heavily damaging consequences. It is consequently essential to study these phenomena in order to assess their potential hazards. In particular, the scope of the present paper focus on floods. The intense floods met these last years showed the importance of this phenomenon as well as its many devastating effects. Thanks to recent important breakthroughs, both in the field of conceptual and numerical modelling of complex flows and in the calculation power of computers, it is henceforth possible to study the effects of potential floods on the basis of numerical simulations, with an accuracy never reached beforehand. The Laboratory of Applied Hydrodynamics and Hydraulic Constructions (HACH) of the University of Liege has always made this kind of study one of its core competencies, thanks to • the development of modern and powerful modelling tools (quasi-three dimensional software for flow simulation by finite volume), • the use of a broad range of data enabling a proper representation of the studied fields (topography, occupation of the ground...) • the systematic validation of simulation results. These tools are currently intensively used within the framework of a general study of the flood-prone zones of the Walloon area of Belgium, which corresponds to more than 800 km of rivers. [less ▲]

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See detailVis maior and vis cui resisti non potest
Gerkens, Jean-François ULg

in Ex iusta traditur. Essays in honour of Eric H. Pool, University of South Africa ( Fundamina Editio specialis (2005)

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See detailSodium nitroprusside-induced osteoblast apoptosis is mediated by long chain ceramide and is decreased by raloxifene.
Olivier, Sabine ULg; Fillet, Marianne ULg; Malaise, Michel ULg et al

in Biochemical Pharmacology (2005), 69(6), 891-901

Release of high levels of nitric oxide (NO) is associated with osteoblastic cell death. The mechanisms of NO-induced cytotoxicity are not well documented and it is presently not known if estrogenic ... [more ▼]

Release of high levels of nitric oxide (NO) is associated with osteoblastic cell death. The mechanisms of NO-induced cytotoxicity are not well documented and it is presently not known if estrogenic compounds prevent this effect. We studied the role of ceramides in cell death induced by the NO donor sodium nitroprusside (SNP) and we tested the possibility that 17beta-estradiol, the anti-estrogen ICI 182.780 and two selective estrogen receptor modulators raloxifene and tamoxifen modify osteoblastic cell apoptosis. SNP dose-dependently decreased MC3T3-E1 osteoblast viability, increased NO production in the culture media and enhanced the release of intracellular ceramides C22 and C24. Cell death induced by SNP was partially inhibited when MC3T3-E1 cells were pretreated with raloxifene and tamoxifen but was not modified when the cells were pretreated with 17beta-estradiol or ICI 182.780. Cell death induced by SNP resulted from apoptosis as demonstrated by Annexin-V and propidium iodide labeling and a reduction of SNP-induced MC3T3-E1 apoptosis was confirmed in the presence of raloxifene and tamoxifen. SNP induction of C22 and C24 production was inhibited by a pretreatment with raloxifene but not with 17beta-estradiol. Moreover, the synthetic ceramide C24 (0.75 and 1microM) decreased MC3T3-E1 cell viability and osteoblast cell death induced by C24 was partially decreased by raloxifene and to a lesser extent by 17beta-estradiol. These data demonstrate that SNP-induced cell death is mediated by the long chain ceramides C22 and C24 and that raloxifene protected osteoblast from apoptosis induced by SNP, an effect that might be relevant to its pharmacological properties on bone remodeling. [less ▲]

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See detailDifferential expression of proteins in response to ceramide-mediated stress signal in colon cancer cells by 2-D gel electrophoresis and MALDI-TOF-MS.
Fillet, Marianne ULg; Cren-Olive, Cécile; Renert, A.-F. et al

in Journal of Proteome Research (2005), 4(3), 870-80

Comparative cancer cell proteome analysis is a strategy to study the implication of ceramides in the transmission of stress signals. To better understand the mechanisms by which ceramide regulate some ... [more ▼]

Comparative cancer cell proteome analysis is a strategy to study the implication of ceramides in the transmission of stress signals. To better understand the mechanisms by which ceramide regulate some physiological or pathological events and the response to the pharmacological treatment of cancer, we performed a differential analysis of the proteome of HCT-116 (human colon carcinoma) cells in response to these substances. We first established the first 2-dimensional map of the HCT-116 proteome. Then, HCT116 cell proteome treated or not with C6-ceramide have been compared using two-dimensional electrophoresis, matrix-assisted laser desorption/ionization-mass spectrometry and bioinformatic (genomic databases). 2-DE gel analysis revealed more than fourty proteins that were differentially expressed in control cells and cells treated with ceramide. Among them, we confirmed the differential expression of proteins involved in apoptosis and cell adhesion. [less ▲]

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See detailTwo-way nested model of mesoscale circulation features in the Ligurian Sea
Barth, Alexander ULg; Alvera Azcarate, Aïda ULg; Rixen, Michel et al

in Progress in Oceanography (2005), 66(2-4), 171-189

A coarse resolution primitive equation model of 1/4 degrees resolution is implemented covering the whole Mediterranea Sea. Within this grid a 1/20 degrees resolution model of the Liguro-Provencal basin ... [more ▼]

A coarse resolution primitive equation model of 1/4 degrees resolution is implemented covering the whole Mediterranea Sea. Within this grid a 1/20 degrees resolution model of the Liguro-Provencal basin and the northern part of the Tyrrhenian Sea is embedded. A third fine resolution model of 1/60 degrees is nested in the latter one and simulates the dynamics of the Ligurian Sea. Comparisons between one-way and two-way nesting in simulating the Northern Current (NC) are made. The properties of the Eastern and Western Corsican Current and the Northern Current are investigated with this nesting system. Special attention is given to the variability of the NC. Meanders and interactions with Winter Intermediate Water lenses are shown. Topographic features also lead to a highly variable NC. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailTrophic position of Antarctic amphipods: enhanced analysis by a 2-dimensional biomarker assay
Nyssen, Fabienne ULg; Brey, Thomas; Dauby, Patrick et al

in Marine Ecology. Progress Series (2005), 300

The discrepancy between the ecological significance of amphipods in the Antarctic and our poor knowledge of their ecofunctional role calls for a more detailed investigation of their trophic status in this ... [more ▼]

The discrepancy between the ecological significance of amphipods in the Antarctic and our poor knowledge of their ecofunctional role calls for a more detailed investigation of their trophic status in this ecosystem. A total of 12 amphipod species from suspension feeder to scavenger have been considered in this study. Our objective was to investigate whether the combination of fatty-acid and stable-isotope signatures into a 2-dimensional trophic biomarker assay would increase accuracy in the identification of Antarctic benthic amphipod trophic position. Amphipod isotopic averages ranged from -29.3 parts per thousand (delta(13)C) and 4.1 parts per thousand (delta(15)N) for the suspension feeder Ampelisca richardsoni to -21.7 parts per thousand (delta(13)C) and 11.9 parts per thousand (delta(15)N) for the high predator Iphimediella sp. Cluster analysis of the fatty-acid composition separated the amphipod species into 4 trophic groups: suspension feeders, macroherbivores, omnivores and scavengers. The suspension feeder was isolated due to an important proportion of 18:4(n-3), a fatty-acid biomarker of phytoplankton. Macro-herbivores were found to rely heavily on macroalgal carbon, containing a high percentage of arachidonic acid (20:4(n-6)). Scavenger amphipods revealed a unique fatty-acid composition dominated by 1 single fatty acid, 18:1(n-9), probably the result of a very intensive de novo biosynthesis to cope with starvation periods. Our data emphasise the need to combine different types of information to be able to draw the right conclusions regarding trophic ecology. Indeed, in some cases, the exclusive use of 1 type of tracing method, fatty acids or stable isotopes, would have resulted in misleading/false conclusions in the trophic classification of amphipods. Therefore, a 2-dimensional biomarker assay is a useful tool to elucidate the trophic positions of benthic amphipods. [less ▲]

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See detailParamètres hydrologiques et physico-chimiques de sources du Crétacé du Pays de Herve et de la Hesbaye sèche
Mols, J.; Petit, François ULg

in Bulletin de la Société Géographique de Liège (2005)

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See detailDans l'atelier du sculpteur Thoutmose
Laboury, Dimitri ULg

in Cannuyer, Christian (Ed.) La langue dans tous ses états. Michel Malaise in honorem (2005)

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See detailContribution à l’étude de l’avifaune de l’île Santay, Equateur
Marechal, Corinne ULg; Hernandez, José Francisco

in Cahiers d'Ethologie (2005), 22(1), 31-42

The avifauna of the Santay island (Guayaquil, Ecuador) has been studied during a six-months period from September 2000 to February 2001. Nearly half covered by mangrove forest, the island (2 200 ha) has ... [more ▼]

The avifauna of the Santay island (Guayaquil, Ecuador) has been studied during a six-months period from September 2000 to February 2001. Nearly half covered by mangrove forest, the island (2 200 ha) has recently been put on the list of the Ramsar Convention. However, very few data exist about its natural resources. The present results are compared to a previous study carried out in 1994. On the whole 130 birds species have been listed in Santay (48 new for the island) among which 20 Emberizidae, 18 Tyrannidae, 16 diurnal raptors, 20 endemic species to Ecuador, Colombia or Peru, 12 migrating species and 10 species both resident and migrating. Some of these species present abundant populations. Several taxa are considered as threatened. These results confirm the high biological value of the island and involve an important potential for the development of ecotouristic activities. [less ▲]

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See detailA Quadrangular Shell Finite Element for Concrete and Steel Structures Subjected to Fire
Talamona, Didier; Franssen, Jean-Marc ULg

in Journal of Fire Protection Engineering (2005), 15

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See detailRelativiser les performances des établissements scolaires : quelle valeur ajoutée ?
Lafontaine, Dominique ULg

in Demeuse, Marc (Ed.) Vers une école juste et efficace : 26 contributions sur les systèmes d'enseignement et de formation : une approche internationale (2005)

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See detailSAFIR: A thermal/structural program for modeling structures under fire
Franssen, Jean-Marc ULg

in Engineering Journal-American Institute of Steel Construction Inc (2005), 42(3), 143-158

This paper describes the fundamental of the computer code SAFIR written for the simulation of structures subjected to fire

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See detailCompte rendu de "Raymond Trousson, La Légende de la Jeune Belgique, Bruxelles, A.R.L.L.F., 2000"
Dozo, Björn-Olav ULg

in Textyles : Revue des Lettres Belges de Langue Française (2005), 26-27

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See detailThe 8 learning Events Model and its principles (Release 2005-1)
Leclercq, Dieudonné ULg; Poumay, Marianne ULg

Learning material (2005)

we have developed a theoretical reference model that has three components: (1) A series of Learning Events (LE), seeking to describe and conceive the multiplicity of learning/teaching experiences and ... [more ▼]

we have developed a theoretical reference model that has three components: (1) A series of Learning Events (LE), seeking to describe and conceive the multiplicity of learning/teaching experiences and their underpinning psychological theories ; (2) a series of Principles helping in designing and evaluating learning environments, and their underpinning educational theories ; (3) a series of more specific descriptors, or metadata, that provide detailed information about the Learning Events, enabling to judge their intrinsic qualities, their underpinning theories (from media properties to group work rules) and their degree of appropriateness to specific learners and situations. The present document is a short description of the two first components: LE and Principles. [less ▲]

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See detailCompte rendu de "Jean Ray / John Flanders, Œuvres complètes. La Flandre libérale, Tome 2, Amicale Jean Ray, 2003"
Dozo, Björn-Olav ULg

in Textyles : Revue des Lettres Belges de Langue Française (2005), 26-27

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